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Journal of Geriatric Oncology

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https://www.readbyqxmd.com/read/29759912/a-call-to-action-in-hematologic-disorders-a-report-from-the-ash-scientific-workshop-on-hematology-and-aging
#1
Ashley E Rosko, Rebecca L Olin, Andrew Artz, Tanya M Wildes, Reinhard Stauder, Heidi D Klepin
No abstract text is available yet for this article.
May 12, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29759914/symptom-cluster-of-emotional-distress-fatigue-and-cognitive-difficulties-among-young-and-older-breast-cancer-survivors-the-mediating-role-of-subjective-stress
#2
Inbar Levkovich, Miri Cohen, Shirly Alon, Iryna Kuchuk, Bella Nissenbaum, Ella Evron, Simon Pollack, Georgeta Fried
OBJECTIVES: To examine the nature of the symptom cluster of emotional distress, fatigue, and cognitive difficulties in young and older breast cancer survivors (BCS); To assess the mediating role of subjective stress and coping strategies (emotional control and meaning-focused coping) in the association between age and symptom cluster. MATERIALS AND METHODS: Participants were 170 BCS, stages I-III, 1-12 months post-chemotherapy, filled-out the Fatigue, Emotional Control, Meaning-focused Coping, Emotional Distress and the Cognitive Difficulties Questionnaires...
May 11, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29759913/improving-implementation-of-psychological-interventions-to-older-adult-patients-with-cancer-convening-older-adults-caregivers-providers-researchers
#3
Kelly M Trevino, Charlotte Healy, Peter Martin, Beverly Canin, Karl Pillemer, Jo Anne Sirey, M Cary Reid
INTRODUCTION: Older adults with cancer (OACs) are a large and growing population. Psychological distress is prevalent in this population yet few OACs receive evidence-based psychological care. The purpose of this project was to identify barriers and strategies for the implementation of psychological interventions to OACs from the perspective of OACs, OAC caregivers, researchers, clinicians, and advocacy organization members. METHODS: The Cornell Research-to-Practice (RTP) Consensus Workshop Model was used to organize and convene a consensus conference...
May 11, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29752141/predictors-of-falls-in-older-survivors-of-breast-and-prostate-cancer-a-retrospective-cohort-study-of-surveillance-epidemiology-and-end-results-medicare-health-outcomes-survey-linkage
#4
Min H Huang, Jennifer Blackwood, Monica Godoshian, Lucinda Pfalzer
OBJECTIVES: To identify predictors of falls in older breast and prostate cancer survivors. METHODS: This retrospective cohort study analyzed population-based Surveillance, Epidemiology and End Results-Medicare Health Outcomes Survey (SEER-MHOS) linkage. Inclusion criteria were age >65 years at cancer diagnosis, first primary female breast or prostate cancer, cancer staging information available, completion of baseline MHOS during years 2-3 and follow-up MHOS during years 4-5 post-diagnosis, and falls information available...
May 8, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29747954/role-of-the-geriatrician-primary-care-practitioner-nurses-and-collaboration-with-oncologists-during-cancer-treatment-delivery-for-older-adults-a-narrative-review-of-the-literature
#5
Martine T E Puts, Fay J Strohschein, M Elisabeth Del Giudice, Rana Jin, Allison Loucks, Ana Patricia Ayala, Shabbir H M Alibhai
Cancer is a disease that mostly affects older adults. With the aging of the population there will be a considerable increase in the number of older adults with cancer. Optimal care of the older adult with cancer requires the involvement of many types of health care providers, including oncologists, nurses, primary care practitioners, and geriatricians. In this narrative review, the literature for evidence relating to the roles of and collaboration between geriatricians, primary care practitioners, nurses, and the oncology team during cancer treatment delivery to older adults was examined...
May 7, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29731344/prognostic-value-%C3%A2-of-lung-cancer-subscale-in-older-patients-with-advanced-non-small-cell-lung-cancer-an-integrated-analysis-of-jcog0207-and-jcog0803-wjog4307l-jcog1414a
#6
Tomonori Mizutani, Masahiko Ando, Junki Mizusawa, Kenichi Nakamura, Haruhiko Fukuda, Hiroko Tsukada, Tetsuya Abe, Koji Takeda, Akira Yokoyama, Shinichiro Nakamura, Kazuhiko Nakagawa, Noboru Yamamoto, Yuichiro Ohe
OBJECTIVE: The Lung Cancer Subscale (LCS) of the Functional Assessment of Cancer Therapy-Lung (FACT-L) questionnaire is commonly used for evaluating lung cancer-specific symptoms. The objective of this study was to elucidate the prognostic value of the LCS in older patients with advanced non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: We conducted an integrated analysis of data from two randomized phase III trials (JCOG0207, JCOG0803/WJOG4307L) including patients aged 70 years or older with advanced NSCLC to evaluate the prognostic value of LCS scores at baseline (Aim 1) and for symptom improvement (an increase in LCS of two points or more during treatment) (Aim 2)...
May 3, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29728308/health-related-quality-of-life-in-older-or-frail-patients-with-advanced-colorectal-cancer-treated-with-dose-reduced-capecitabine
#7
Daniel Breadner, Mark David Vincent, Derek Jonker, Christine Cripps, Paul Klimo, James Biagi, Wendy Lam, Anne O'Connell, Frances Whiston, Larry Stitt, Stephen Welch
OBJECTIVES: Palliative chemotherapy's role is to prolong survival while minimizing treatment toxicities to preserve or improve quality of life. We have recently published a phase II trial of dose reduced capecitabine in older or frail patients with advanced colorectal cancer (aCRC). We herein provide a robust analysis of the health related quality of life (HRQoL) data from our trial. METHODS: A single arm multi-centered phase II trial of dose reduced capecitabine (1500 or 2000 mg/m2  days one-fourteen q21 days) in older or frail patients...
May 1, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29706424/patient-and-tumor-related-predictors-of-chemotherapy-intolerance-in-older-patients-with-cancer-a-systematic-review
#8
REVIEW
Doris L van Abbema, Marjan van den Akker, Maryska L Janssen-Heijnen, Franchette van den Berkmortel, Ann Hoeben, Judith de Vos-Geelen, Frank Buntinx, Jos Kleijnen, Vivianne C G Tjan-Heijnen
OBJECTIVE: The aim of this systematic review was to investigate patient-related factors (e.g. depressive symptoms, cognition, mobility, activities of daily living (ADL)) as well as tumor-related factors (e.g. tumor type, chemotherapy regimen) influencing chemotherapy intolerance in cancer patients aged 65 years or older. METHODS: We included observational studies that reported data on possible predictors of chemotherapy intolerance in older patients with cancer...
April 26, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29699938/black-white-disparity-in-physical-performance-among-older-women-with-newly-diagnosed-non-metastatic-breast-cancer-exploring-the-role-of-inflammation-and-physical-activity
#9
Cynthia Owusu, Mark Schluchter, Siran M Koroukian, Kathryn H Schmitz, Nathan A Berger
OBJECTIVE: To examine racial differences in physical performance among older women with newly diagnosed non-metastatic breast cancer and identify clinical, behavioral and biological factors that might contribute to such disparities. METHODS: This is a cross-sectional study of women aged ≥65 years with newly diagnosed stage I-III breast cancer recruited from ambulatory oncology clinics at an academic center, between September 2010 and August 2015. Participants completed a Comprehensive Geriatric Assessment and laboratory testing for biomarkers of inflammation [interleukin-6 (IL6)] prior to receiving systemic treatment for cancer...
April 23, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29691196/clinical-characteristics-and-outcomes-of-older-women-with-breast-cancer-in-mexico
#10
Paula Cabrera-Galeana, Enrique Soto-Perez-de-Celis, Nancy Reynoso-Noverón, Cynthia Villarreal-Garza, Claudia Arce-Salinas, Juan Matus-Santos, María Teresa Ramírez-Ugalde, Alberto Alvarado-Miranda, Abelardo Meneses-García, Fernando Lara-Medina, Juan Torres-Dominguez, Enrique Bargalló-Rocha, Alejandro Mohar
INTRODUCTION: Although the epidemiology of breast cancer in older women has been widely described before, little is known about the clinical characteristics and prognosis of older patients living in developing countries. Here, we studied older women with breast cancer treated at a public cancer center in Mexico City, and compared their outcomes with their younger counterparts. MATERIALS AND METHODS: We retrospectively analyzed a database of 5488 women treated for breast cancer at a single institution...
April 21, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29685382/managing-older-patients-with-head-and-neck-cancer-the-non-surgical-curative-approach
#11
Muhammad Shahid Iqbal, Divyanshu Dua, Charles Kelly, Paolo Bossi
Managing older patients with head and neck cancers poses a challenge due to the often reduced levels of physiological reserve, the frequent comorbidities and treatment related toxicity. These factors have implications on speech, breathing and swallowing functions. Treatment management plans in these patients may result in de-intensification strategies and as a result of this, use of non-standard treatments is increasing. There have been published reports that indicate the addition of concurrent systemic therapy to radiation in selected older patients is feasible, and produces outcomes comparable with younger patients...
April 20, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29685381/an-onco-geriatric-approach-to-select-older-patients-for-optimal-treatments-of-pancreatic-adenocarcinoma
#12
Elisabeth Castel-Kremer, Solene De Talhouet, Anne-Laure Charlois, Emmanuelle Graillot, Xavier Chopin-Laly, Mustapha Adham, Brigitte Comte, Catherine Lombard-Bohas, Thomas Walter, Gilles Boschetti
INTRODUCTION: Pancreatic adenocarcinoma affects mainly older patients. Surgery is indicated for localized tumors while chemotherapy alone is proposed in advanced or metastatic tumors. OBJECTIVE: To evaluate the feasibility of standard of care oncologic treatments in this population, the accuracy of the geriatric evaluation to predict the ability of patients to tolerate the recommended treatments and to identify specific geriatric prognosis factors. METHODS: We included, between 2007 and 2014, all consecutive patients over 70 years of age with a pathologically diagnosed pancreatic cancer...
April 20, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29685380/low-levels-of-intra-tumoural-t-cells-in-breast-cancer-identify-clinically-frail-patients-with-shorter-disease-specific-survival
#13
Lisa Speigl, Alexandra Grieb, Nicole Janssen, Sigrid Hatse, Barbara Brouwers, Ann Smeets, Giuseppe Floris, Jithendra Kini Bailur, Cindy Kenis, Patrick Neven, Hans Wildiers, Graham Pawelec, Christopher Shipp
OBJECTIVES: The global health status of older patients with cancer influences their clinical course, but little is known regarding the influence of the immune system on the global health of older patients with cancer. The goal of this study was to assess the relationships between patient fitness/frailty status and survival, and the local tumour immune environment of older patients with breast cancer. MATERIALS AND METHODS: In a cohort of 58 older patients with breast cancer (over 70 years of age), fluorescence microscopy was used to investigate whether levels of intra-tumoural T cells (CD3+) and granulocytic cells (CD15+) could predict patient clinical outcome, and/or whether they correlated with patient physical and mental performance as evaluated by comprehensive geriatric assessment...
April 20, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29680585/functional-and-cognitive-impairment-social-functioning-frailty-and-adverse-health-outcomes-in-older-patients-with-esophageal-cancer-a-systematic-review
#14
Floor J van Deudekom, Henk G Klop, Henk H Hartgrink, Jurjen J Boonstra, Irene M Lips, Marije Slingerland, Simon P Mooijaart
BACKGROUND: Older patients with esophageal cancer are at high risk of adverse health outcomes, but the association of geriatric assessment with adverse health outcomes in these patients has not been systematically evaluated. The aim of this systematic review was to study the association of functional and cognitive impairment, social environment and frailty with adverse health outcomes in patients diagnosed with esophageal cancer. METHODS: We searched Pubmed, Embase, Web of Science and Cochrane Library for original studies reporting on associations of functional or cognitive impairment, social environment and frailty with adverse outcomes (mortality, functional or cognitive decline, adverse events during treatment, prolonged length of hospitalization (LOS) and health related quality of life (HRQoL)) after follow-up in patients with esophageal cancer...
April 18, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29678669/using-big-data-in-oncology-to-prospectively-impact-clinical-patient-care-a-proof-of-concept-study
#15
Vérène Dougoud-Chauvin, Jae Jin Lee, Edgardo Santos, Vonetta L Williams, Nicolò M L Battisti, Kavita Ghia, Marina Sehovic, Cortlin Croft, Jongphil Kim, Lodovico Balducci, Julie A Kish, Martine Extermann
OBJECTIVE: Big Data is widely seen as a major opportunity for progress in the practice of personalized medicine, attracting the attention from medical societies and presidential teams alike as it offers a unique opportunity to enlarge the base of evidence, especially for older patients underrepresented in clinical trials. This study prospectively assessed the real-time availability of clinical cases in the Health & Research Informatics Total Cancer Care™ (TCC) database matching community patients with cancer, and the impact of such a consultation on treatment...
April 17, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29678668/the-effect-of-music-on-postoperative-recovery-in-older-patients-a-systematic-review
#16
Hanneke van der Wal-Huisman, Karolien S K Dons, Rineke Smilde, Erik Heineman, Barbara L van Leeuwen
OBJECTIVE: Surgery is an important part of the treatment modalities offered to older patients with cancer. Natural ageing processes lead to deterioration of organ function, making older patients more vulnerable and at risk for experiencing less-favourable outcomes and complications after surgery. Non-pharmaceutical interventions, such as music, may be preferable to medical interventions in older people, who are at risk for adverse effects and drug interactions due to altered physiology and drug metabolism...
April 17, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29673807/frequency-and-impact-of-grade-three-or-four-toxicities-of-novel-agents-on-outcomes-of-older-patients-with-chronic-lymphocytic-leukemia-and-non-hodgkin-lymphoma-alliance-a151611
#17
Michael Tallarico, Jared C Foster, Drew Seisler, Jacqueline M Lafky, Arti Hurria, Aminah Jatoi, Harvey J Cohen, Hyman B Muss, Nancy Bartlett, Bruce D Cheson, Sin-Ho Jung, John P Leonard, John C Byrd, Chadi Nabhan
OBJECTIVE: Older patients with cancer suffer from chemotherapy-related toxicities more frequently than younger patients. As novel agents are being used more commonly in chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL), toxicities of these agents in older patients have not been well studied. Further, impact of these toxicities on outcomes in the elderly is unknown. This study aimed to answer both questions. PATIENTS AND METHODS: We reviewed 14 Alliance for Clinical Trials in Oncology trials that enrolled CLL and/or NHL patients between 2004-2014...
April 16, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29673806/the-challenges-of-bacillus-of-calmette-guerin-bcg-therapy-for-high-risk-non-muscle-invasive-bladder-cancer-treatment-in-older-patients
#18
Marco Racioppi, Luca Di Gianfrancesco, Mauro Ragonese, Giuseppe Palermo, Emilio Sacco, PierFrancesco Bassi
OBJECTIVES: To evaluate the efficacy and safety of a tailored endovesical immunotherapy protocol with biweekly BCG for elderly Patients with high risk non muscle invasive bladder cancer (HG-NMIBC). MATERIALS AND METHODS: We retrospectively evaluated data from 200 patients older than 80 years newly diagnosed with HG-NMIBC: 100 (group 1) with multiple comorbidities (WHO PS 2-3, ASA score ≥3, Charlson Comorbidity index ≥3, GFR<60 mL/min) were treated with BCG induction course administered biweekly; 100 (group 2) with statistically significant better conditions were treated with standard weekly BCG therapy...
April 16, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29669700/a-tribute-to-jimmie-holland-pioneer-for-geriatric-oncology
#19
Christian J Nelson, William P Tew, Arti Hurria
No abstract text is available yet for this article.
April 15, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29650403/is-age-a-risk-factor-for-depression-among-the-oldest-old-with-cancer
#20
Gil Goldzweig, Lea Baider, Yakir Rottenberg, Elisabeth Andritsch, Jeremy M Jacobs
INTRODUCTION: Age is negatively related to depression among young and middle age patients with cancer. Nevertheless the relationship between age and depression among older patients with cancer is unclear. The goal of the current study is to assess the association of depression with increasing age among older patients with cancer. MATERIALS AND METHODS: Participants were 243 oncology out-patients, aged ≥65, either receiving treatment for active disease or within 6 months of completing treatment for active disease, with a Karnofsky score ≥70...
April 9, 2018: Journal of Geriatric Oncology
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