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Journal of Geriatric Oncology

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https://www.readbyqxmd.com/read/29212610/moving-beyond-symptom-management-towards-cancer-rehabilitation-for-older-adults-answering-the-5w-s
#1
REVIEW
Mackenzi Pergolotti, Kathleen D Lyons, Grant R Williams
Older adults with cancer are quickly becoming the largest group of cancer survivors. Chronological age is a poor predictor of cancer treatment outcomes and of the need for rehabilitation services. While newer symptom management systems and assessments are slowly becoming used in the clinic to improve communication between providers and survivors, such assessments are rarely used to trigger a referral to rehabilitation. Cancer rehabilitation for older adults with cancer has the potential to improve the quality of life and decrease disability caused by cancer and its treatments...
December 3, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29195906/patterns-and-predictors-of-emergency-department-visits-among-older-patients-after-breast-cancer-surgery-a-population-based-cohort-study
#2
Tracy Westley, Ania Syrowatka, David Henault, Young-Soo Rho, Francois Khazoom, Sue-Ling Chang, Robyn Tamblyn, Nancy Mayo, Ari N Meguerditchian
OBJECTIVES: To characterize rates, reasons for, and associated predictors for emergency department (ED) visits after breast cancer (BC) surgery. METHODS: All women over 65 years undergoing curative surgery for non-metastatic incident BC (1998-2012) were identified using Quebec's universal healthcare administrative databases. Reasons for ED visits within 45days of operation were reported. Associated factors were estimated using Cox regression. RESULTS: Of 24,463 patients, 12...
November 28, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29174929/erratum-to-trans-sectoral-care-of-geriatric-cancer-patients-based-on-comprehensive-geriatric-assessment-and-patient-reported-quality-of-life-results-of-a-multicenter-study-to-develop-and-pilot-test-a-patient-centered-interdisciplinary-care-concept-for-geriatric
#3
Heike Schmidt, Stephanie Boese, Katharina Lampe, Karin Jordan, Eckhard Fiedler, Ursula Müller-Werdan, Andreas Wienke, Dirk Vordermark
No abstract text is available yet for this article.
November 23, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29174187/risk-of-cancer-death-by-comorbidity-severity-and-use-of-adjuvant-chemotherapy-among-women-with-locoregional-breast-cancer
#4
Gretchen G Kimmick, Xiangrong Li, Steven T Fleming, Susan A Sabatino, J Frank Wilson, Joseph Lipscomb, Rosemary Cress, Carmen Bergom, Roger T Anderson, Xiao-Cheng Wu
OBJECTIVES: To examine the associations of comorbidity and chemotherapy with breast cancer- and non-breast cancer-related death. MATERIALS AND METHODS: Included were women with invasive locoregional breast cancer diagnosed in 2004 from seven population-based cancer registries. Data were abstracted from medical records and verified with treating physicians when there were inconsistencies and missing information on cancer treatment. Comorbidity severity was quantified using the Adult Comorbidity Evaluation 27...
November 22, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29174186/safety-and-efficacy-of-eribulin-for-real-world-older-patients-with-metastatic-breast-cancer
#5
LETTER
Alexandre de Nonneville, Renaud Sabatier, Anthony Gonçalves, Jean-Marc Extra, Carole Tarpin, Simon Launay, Louis Tassy, Patrice Viens, Frederique Rousseau
No abstract text is available yet for this article.
November 22, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29174632/recent-cancer-treatment-and-memory-decline-in-older-adults-an-analysis-of-the-2002-2012-health-and-retirement-study
#6
Krystle E Zuniga, Nicholas J Bishop
OBJECTIVE: Few studies have examined the impact of cancer treatment on cognitive trajectories in the growing population of older adults diagnosed with and surviving cancer. This study examined whether recent cancer and its treatment accelerated memory decline in older adults. MATERIALS AND METHODS: We conducted a secondary analysis of observations drawn from the Health and Retirement Study (2002-2012), a population-based sample of older adults in the United States...
November 21, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29170049/brachytherapy-for-conservative-treatment-of-invasive-penile-carcinoma-in-older-patients-single-institution-experience
#7
Alexandre Escande, Pierre Maroun, Isabelle Dumas, Antoine Schernberg, Alberto Bossi, Renaud De Crevoisier, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
BACKGROUND: No study has examined the possibility to perform an organ sparing strategy in older patients with penile carcinoma, and amputation is frequently proposed. We report our experience of interstitial brachytherapy for the conservative treatment of penile carcinoma confined to the glans in patients aged of 70years and more. METHODS: A total of 55 patients candidates to conservative brachytherapy were identified. Median age was 73.8years (range: 70-95years)...
November 20, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29167064/the-effect-of-adjuvant-chemotherapy-on-symptom-burden-and-quality-of-life-over-time-a-preliminary-prospective-observational-study-using-individual-data-of-patients-aged-%C3%A2-70-with-early-stage-invasive-breast-cancer
#8
Chantal Quinten, C Kenis, M Hamaker, A Coolbrandt, B Brouwers, L Dal Lago, P Neven, P Vuylsteke, G Debrock, H Van Den Bulck, A Smeets, P Schöffski, A Bottomley, U Wedding, H Wildiers
OBJECTIVES: We aim to assess short and long term effects of chemotherapy on patient-reported quality of life (QOL) and patient versus clinician symptom reporting in older patients with breast cancer adjusted for tumour and aging parameters. MATERIAL AND METHODS: In this prospective, multicentre, non-interventional, observational study, women aged ≥70years were enrolled after surgery and assigned to a TC chemotherapy (docetaxel and cyclophosphamide) group or a control group depending on their planned adjuvant treatment...
November 19, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29133190/integrating-geriatric-assessment-in-the-first-line-chemotherapy-treatment-in-older-patients-with-metastatic-colorectal-cancer-results-of-a-prospective-observational-cohort-study-avaplus
#9
Lore Decoster, Cindy Kenis, Benedicte Naessens, Ghislain Houbier, Marc De Man, Guy Lambrecht, Els Monsaert, Veerle Moons, Philippe Vergauwe, Hans Prenen, Eric Van Cutsem, Hans Wildiers
OBJECTIVES: This study aims to investigate the use of chemotherapy with or without bevacizumab in older patients with metastatic colorectal cancer (mCRC) in current daily practice and to identify predictive parameters for treatment-related outcomes. PATIENTS AND METHODS: This is a Belgian multi-centre, observational cohort study. Patients≥70years old with mCRC considered suitable for first-line chemotherapy were eligible for inclusion. At baseline geriatric screening and assessment was performed...
November 10, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29129470/risk-stratification-for-surgical-outcomes-in-older-colorectal-cancer-patients-using-isar-hp-and-g8-screening-tools
#10
Esteban T D Souwer, Norbert M Verweij, Frederiek van den Bos, Esther Bastiaannet, Rob M E Slangen, Willem H Steup, Marije E Hamaker, Johanna E A Portielje
BACKGROUND: Older patients are at risk for adverse outcomes after surgical treatment of cancer. Identifying patients at risk could affect treatment decisions and prevent functional decline. Screening tools are available to select patients for Geriatric Assessment. Until now their predictive value for adverse outcomes in older colorectal cancer patients has not been investigated. OBJECTIVE: To study the predictive value of the Geriatric 8 (G8) and Identification of Seniors at Risk for Hospitalized Patients (ISAR-HP) screening tools for adverse outcomes after elective colorectal surgery in patients older than 70years...
November 9, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29056336/the-impact-of-age-and-comorbidities-on-practice-patterns-and-outcomes-in-patients-with-relapsed-refractory-multiple-myeloma-in-the-era-of-novel-therapies
#11
Parameswaran Hari, Dorothy Romanus, Katarina Luptakova, Marlo Blazer, Candice Yong, Aditya Raju, Eileen Farrelly, Richard Labotka, Vicki A Morrison
OBJECTIVES: One-third of patients with multiple myeloma (MM) are diagnosed at age≥75years. Older patients have increased incidence of cardiovascular disease (CVD) and renal insufficiency (RI), hallmark complications of MM. We examined cumulative incidence of CVD and RI in relapsed/refractory MM (RRMM) and outcomes by age and RI/CVD. MATERIALS AND METHODS: Retrospective cohort study using a large US electronic medical records database of adult patients with RRMM initiating first- and second-line therapy (2LT) between 1/2008-06/2015...
October 19, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29055624/geriatric-assessment-and-biomarkers-in-patients-with-metastatic-breast-cancer-receiving-first-line-mono-chemotherapy-results-from-the-randomized-phase-iii-pelican-trial
#12
Friedemann Honecker, Nadia Harbeck, Claudia Schnabel, Ulrich Wedding, Dirk Waldenmaier, Steffen Saupe, Elke Jäger, Marcus Schmidt, Rolf Kreienberg, Lothar Müller, Burkhard Otremba, Julia Dorn, Mathias Warm, Salah-Eddin Al-Batran, Maike de Wit
OBJECTIVES: To determine predictive/prognostic factors for patients with metastatic breast cancer (MBC) receiving first-line monochemotherapy using biomarker analysis and geriatric assessment (GA). MATERIALS AND METHODS: Karnofsky Performance Status (KPS) and GA as clinical parameters, and prognostic inflammatory and nutritional index (PINI), and Glasgow prognostic score (GPS) as biomarkers were analyzed for association with clinical outcome within the randomized phase III PEg-LIposomal Doxorubicin vs...
October 18, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29030150/sociodemographic-socioeconomic-and-clinical-determinants-of-survival-in-patients-with-cancer-a-systematic-review-of-the-literature-focused-on-the-elderly
#13
REVIEW
Angéline Galvin, Fleur Delva, Catherine Helmer, Muriel Rainfray, Carine Bellera, Virginie Rondeau, Pierre Soubeyran, Gaëlle Coureau, Simone Mathoulin-Pélissier
Studies on cancer survival have revealed disparities not only between the elderly and their younger counterparts, but also among the elderly themselves. The aim of this work was to identify sociodemographic, socioeconomic, clinical, and care-related determinants of survival or mortality in older patients with cancer by a systematic synthesis of the literature. Understanding these factors is of great value for guiding health policies and programs aimed at reducing cancer survival disparities. We conducted a search of MEDLINE and SCOPUS databases under PRISMA guidelines...
October 10, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29032962/the-impact-of-postoperative-complications-on-health-related-quality-of-life-in-older-patients-with-rectal-cancer-a-prospective-cohort-study
#14
Alice M Couwenberg, Fleur S A de Beer, Martijn P W Intven, Johannes P M Burbach, Anke B Smits, Esther C J Consten, Anandi H W Schiphorst, Niels A T Wijffels, Marnix A J de Roos, Marije E Hamaker, Wilhemina M U van Grevenstein, Helena M Verkooijen
OBJECTIVES: As result of the aging population and increasing rectal cancer incidence, more older patients undergo treatment for rectal cancer. This study compares treatment course, postoperative complications, and quality of life (QOL) between older and younger patients with rectal cancer and evaluates the impact of postoperative complications on QOL in the elderly. MATERIALS AND METHODS: Patients with rectal cancer participating in a prospective colorectal cancer cohort and referred for radiotherapy between 2013 and 2016 were included...
October 9, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29017891/a-pilot-study-of-an-accelerometer-equipped-smartphone-to-monitor-older-adults-with-cancer-receiving-chemotherapy-in-mexico
#15
Enrique Soto-Perez-De-Celis, Heeyoung Kim, María Patricia Rojo-Castillo, Can-Lan Sun, Yanin Chavarri-Guerra, Ana Patricia Navarrete-Reyes, James R Waisman, José Alberto Avila-Funes, Álvaro Aguayo, Arti Hurria
OBJECTIVES: Older adults with cancer in developing countries face challenges accessing healthcare due to a lack of personnel and infrastructure. A decline in physical activity (defined as a decrease in the number of daily steps) may be a novel method for the timely detection of toxicity in older adults receiving chemotherapy in resource-constrained settings. MATERIALS AND METHODS: In this feasibility study, patients aged ≥65years starting first-line chemotherapy for solid tumors were given a smartphone with a pedometer application...
October 7, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28988631/necessity-of-d2-lymph-node-dissection-in-older-patients-%C3%A2-80years-with-gastric-cancer
#16
Ho Seok Seo, Yoon Ju Jung, Ji Hyun Kim, Cho Hyun Park, Han Hong Lee
OBJECTIVES: This study analyzed the effect of D2 lymph node (LN) dissection on complications and survival in older patients with gastric cancer. MATERIALS AND METHODS: A total of 103 octogenarian patients who underwent curative gastrectomy for gastric cancer were divided into two groups (D2 and D1) according to the extent of LN dissection and analyzed retrospectively for complications and survival. RESULTS: No differences were observed in short-term postoperative outcomes, including complication rates, between the two groups...
October 4, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28978411/in-memory-of-claude-jasmin-a-prophet-of-geriatric-oncology
#17
EDITORIAL
Lodovico Balducci
No abstract text is available yet for this article.
October 1, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28941581/use-of-frailty-to-predict-survival-in-elderly-patients-with-early-stage-non-small-cell-lung-cancer-treated-with-stereotactic-body-radiation-therapy
#18
Idalid Franco, Yu-Hui Chen, Fallon Chipidza, Vishesh Agrawal, John Romano, Elizabeth Baldini, Aileen Chen, Yolonda Colson, Ying Hou, David Kozono, Jon Wee, Raymond Mak
OBJECTIVES: Frailty has been shown to increase morbidity and mortality independent of age, but studies are lacking in radiation oncology. This study evaluates a modified frailty index (mFI) in predicting overall survival (OS) and non-cancer death for Stage I/II [N0M0] Non-Small-Cell Lung Cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT). MATERIALS AND METHODS: Medical records for all patients with Stage I/II NSCLC treated at our institution with SBRT from 2009 to 2014 were reviewed...
September 20, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28939384/are-prostate-biopsies-necessary-for-all-patients-75years-and-older
#19
Yuke Chen, Yu Fan, Yang Yang, Jie Jin, Liqun Zhou, Zhisong He, Zheng Zhao, Qun He, Xiaoying Wang, Wei Yu, Shiliang Wu
PURPOSE: To develop nomograms predicting prostate cancer (PCa) and high-grade PCa (HGPCa) in the elderly population. METHODS: We reviewed the data of patients aged 75years and older who underwent first-time prostate biopsy and multiparametric magnetic resonance imaging (mpMRI). The nomograms were developed based on multivariate analysis and evaluated. We performed the external validation and calibration of the risk calculators from the European Randomized Study of Screening for Prostate Cancer (ERSPC) and the Prostate Cancer Prevention Trial (PCPT)...
September 19, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28927748/the-oldest-old-within-the-comprehensive-home-palliative-care-program-of-the-ant-foundation-in-italy-for-advanced-cancer-patients
#20
LETTER
Andrea A Martoni, Brunella Boltri, Elena Strocchi, Franco Pannuti
No abstract text is available yet for this article.
September 15, 2017: Journal of Geriatric Oncology
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