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Journal of Geriatric Oncology

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https://www.readbyqxmd.com/read/28223073/immunotherapy-comes-of-age-immune-aging-checkpoint-inhibitors
#1
REVIEW
Rawad Elias, Theodoros Karantanos, Elizabeth Sira, Kevan L Hartshorn
Immune checkpoint inhibitors (ICIs) are based on the understanding that there are multilayered checks and balances which can be manipulated to unleash already existing, but paralyzed, immune responses to cancer. These agents are safer and more efficacious than classic cytotoxic drugs making them a very attractive therapeutic option, especially in older adults. Current available data do not suggest significant age-associated differences in the clinical profile of ICIs. It must be noted, however, that there is still relatively little information on the use of ICIs in adults over 75years of age and aging is associated with a decline in the immune system or "immunosenescence" which theoretically can reduce the efficacy of these immune based therapies...
February 17, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28216387/corrigendum-to-long-term-results-of-a-concomitant-boost-radiotherapy-technique-for-elderly-patients-with-muscle-%C3%A4-nvasive-bladder-cancer-j-geriatr-oncol6-4-july-2015-316-323
#2
Emine Canyilmaz, Adnan Yoney, Lasif Serdar, Gonca Hanedan Uslu, Ozlem Aynaci, Emel Haciislamoglu, Melek Nur Yavuz
No abstract text is available yet for this article.
February 16, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28169196/patterns-of-care-of-cervical-cancer-in-the-elderly-a-qualitative-literature-review
#3
Venkatesulu Bhanu Prasad, Supriya Mallick, G K Rath
INTRODUCTION: Cancer of the uterine cervix is the fourth most common cancer worldwide among women. However, there is limited data about elderly cervical cancer patients and gross underrepresentation of elderly patients in clinical trials. Hence, the optimal therapy of such patients is not well formulated. METHODOLOGY: We conducted this systematic review of evidence to assess patterns of care in elderly patients with cervical cancer. RESULTS: A total of 17,338 publications are reported in PubMed until July, 2016 pertaining to cervical cancer...
February 3, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28162980/multimorbidity-and-aggressiveness-of-care-at-the-end-of-life-among-older-adults-with-cancer
#4
EDITORIAL
Ryan D Nipp, Jennifer S Temel
No abstract text is available yet for this article.
February 2, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28162979/care-for-the-caregivers
#5
EDITORIAL
Betty Ferrell
No abstract text is available yet for this article.
February 2, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28159513/functional-status-decline-in-older-patients-with-breast-and-colorectal-cancer-after-cancer-treatment-a-prospective-cohort-study
#6
Doris van Abbema, Arnée van Vuuren, Franchette van den Berkmortel, Marjan van den Akker, Laura Deckx, Frank Buntinx, Roel van Kampen, Els Lambooij, Maaike de Boer, Judith de Vos-Geelen, Vivianne C Tjan-Heijnen
OBJECTIVES: The aim of the present study was to disentangle the impact of age and that of cancer diagnosis and treatment on functional status (FS) decline in older patients with cancer. MATERIALS AND METHODS: Patients with breast and colorectal cancer aged 50-69years and aged ≥70years who had undergone surgery, and older patients without cancer aged ≥70years were included. FS was assessed at baseline and after 12months follow-up, using the Katz index for activities of daily living (ADL) and the Lawton scale for instrumental activities of daily living (IADL)...
January 31, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28130010/old-age-an-extra-risk-for-febrile-neutropenia
#7
EDITORIAL
Jean Klastersky, Lissandra Dal Lago
No abstract text is available yet for this article.
January 24, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28119041/a-multi-center-open-label-randomized-phase-iii-trial-of-first-line-chemotherapy-with-capecitabine-monotherapy-versus-capecitabine-plus-oxaliplatin-in-elderly-patients-with-advanced-gastric-cancer
#8
In Gyu Hwang, Jun Ho Ji, Jung Hun Kang, Hyo Rak Lee, Hui-Young Lee, Kyong-Choun Chi, Suk Won Park, Su Jin Lee, Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang
OBJECTIVES: More than half of cases of gastric cancer (GC) are diagnosed in elderly patients (≥70years). While doublet combination with fluoropyrimidines and platinum is currently considered standard first-line chemotherapy in advanced GC, the main goal of chemotherapy remains palliation. MATERIALS AND METHODS: In a multi-center phase III trial, patients with chemotherapy-naïve, metastatic GC, aged 70years or older were randomized 1:1 to receive X monotherapy (capecitabine 1000mg/m(2) bid po on days one to fourteen) or XELOX (X plus oxaliplatin 110mg/m(2) iv on D1)...
January 21, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28041970/effect-of-advanced-age-on-peri-operative-outcomes-after-robotic-assisted-pulmonary-lobectomy-retrospective-analysis-of-287-consecutive-cases
#9
Kathryn S Kass, Frank O Velez-Cubian, Wei Wei Zhang, Kavian Toosi, Tawee Tanvetyanon, Kathryn L Rodriguez, Matthew R Thau, Joseph R Garrett, Carla C Moodie, Jacques P Fontaine, Eric M Toloza
OBJECTIVES: We investigated whether advanced age affects peri-operative outcomes after robotic-assisted pulmonary lobectomies. MATERIALS AND METHODS: We retrospectively analyzed patients who underwent robotic-assisted lobectomy by one surgeon over a 5-year period. Rates of postoperative complications were compared according to age group. Other outcomes, such as intraoperative complications, hospital length of stay (LOS), and in-hospital mortality, were also compared...
December 29, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28024799/assessment-of-older-patients-with-cancer-edmonton-frail-scale-efs-as-a-predictor-of-adverse-outcomes-in-older-patients-undergoing-radiotherapy
#10
Lorna G Keenan, Michelle O'Brien, Tim Ryan, Mary Dunne, Orla McArdle
OBJECTIVE: In this study we evaluate the usefulness of the Edmonton Frail Scale (EFS) in predicting which older patients are at risk of developing serious toxicities during radiotherapy. MATERIALS AND METHODS: This prospective study was carried out over an 18month period. Our primary aim was to examine the Edmonton Frail Scale (EFS) as a predictor of toxicity in patients over 70years undergoing radical radiotherapy for any malignant diagnosis. RESULTS: 63 patients were recruited: 29% experienced grade 3 or greater toxicities, with very few having multiple grade 3 or greater toxicities...
December 23, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28017687/further-psychometric-validation-of-the-gah-scale-responsiveness-and-effect-size
#11
Alfonso José Cruz-Jentoft, Bernardo González, Javier de la Rubia, José Ángel Hernández Rivas, Juan Alfonso Soler, Carlos Fernández Lago, Mario Arnao, Mercedes Gironella, Ernesto Pérez Persona, María Teresa Zudaire, Carmen Olivier, Alberto Altés, Antonio García Guiñón, Benet Nomdedeu, Montserrat Arnan, Ángel Ramírez Payer, Pedro Sánchez-Godoy, Nuria Pajuelo, David Vilanova, Diego Fernánez Monjil, Santiago Bonanad
OBJECTIVES: The purpose of this study was to assess the responsiveness of the newly developed Geriatric Assessment in Hematology (GAH) scale to clinical change in older patients diagnosed with hematologic malignancies. METHODS: A prospective observational study conducted in 164 patients aged ≥65years and diagnosed with myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML), multiple myeloma (MM), or chronic lymphocytic leukemia (CLL). Responsiveness of the GAH scales was studied by means of the Eastern Cooperative Oncology Group (ECOG) score, the Karnofsky performance status (KPS) score, the visual analog scale (VAS), and the physician's subjective assessment, used as clinical anchors to identify whether patients had changed clinically (either improved or worsened) or not since the baseline visit...
December 22, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28017686/enrollment-of-older-adults-on-oncology-trials-an-fda-perspective
#12
Harpreet Singh, Julia A Beaver, Geoffrey Kim, Richard Pazdur
No abstract text is available yet for this article.
December 22, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27993461/designing-geriatric-specific-trials-in-advanced-lung-cancer-what-who-and-how-to-study
#13
EDITORIAL
Ajeet Gajra
No abstract text is available yet for this article.
December 16, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27989612/psychological-stress-in-geriatric-patients-with-genito-urinary-cancers
#14
Désirée Louise Dräger, Chris Protzel, Oliver W Hakenberg
BACKGROUND: Two-thirds of all cancer cases affect patients who are older than 65years, yet the specific conditions of the treatment and supportive care in this age group are poorly studied. There are limited data on the specific psycho-oncological problems in elderly patients with genito-urinary cancers. The aim of this study was to investigate the psychosocial needs of elderly patients with genito-urinary tumors using screening questionnaires and to use such screening questionnaires for an in-patient psychosocial treatment program...
December 15, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27986501/motivation-and-mortality-in-older-women-with-early-stage-breast-cancer-a-longitudinal-study-with-ten-years-of-follow-up
#15
Clark Dumontier, Kerri M Clough-Gorr, Rebecca A Silliman, Andreas E Stuck, André Moser
OBJECTIVES: The Getting Out of Bed Scale (GOB) was validated as a health-related quality of life (HRQoL) variable in older women with early stage breast cancer, suggesting its potential as a concise yet powerful measure of motivation. The aim of our project was to assess the association between GOB and mortality over 10years of follow-up. MATERIALS AND METHODS: We studied 660 women ≥65-years old diagnosed with stage I-IIIA primary breast cancer. Data were collected over 10years of follow-up from interviews, medical records, and death indexes...
December 13, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27986500/omission-of-axillary-staging-in-elderly-patients-with-early-stage-breast-cancer-impacts-regional-control-but-not-survival-a-systematic-review-and-meta-analysis
#16
REVIEW
Shuyin Liang, Julie Hallet, Jory S Simpson, Andrea C Tricco, Adena S Scheer
INTRODUCTION: Management of early breast cancer in the elderly population is challenging due to different breast cancer biology and limited tolerance to aggressive treatments. The aim of this study is to evaluate whether the omission of axillary staging impacts breast cancer outcomes in elderly patients. PATIENTS AND METHODS: A systematic review and meta-analysis was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines...
December 13, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27974265/management-of-elderly-patients-suffering-from-cancer-assessment-of-perceived-burden-and-of-quality-of-life-of-primary-caregivers
#17
Victor Germain, Tienhan Sandrine Dabakuyo-Yonli, Sophie Marilier, Alain Putot, Leila Bengrine-Lefevre, Patrick Arveux, Patrick Manckoundia, Valérie Quipourt
OBJECTIVE: To evaluate the perceived burden and the quality of life (QoL) at 3 and 6months of the primary caregiver (PC) of patients aged 70 and over suffering from cancer and the predictors of QoL in this population. METHODS: In this prospective observational study, 98 patients aged 70 and older with cancer and 96 PCs were included between 01/06/2014 and 18/03/2015. The Medical Outcomes Study 12-item Short Form Health Survey (SF-12) was used to assess the QoL of PCs and the Zarit Burden Interview (ZBI) was used to measure the perceived burden at 3 and 6months...
December 11, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27964884/abridged-geriatric-assessment-is-a-better-predictor-of-overall-survival-than-the-karnofski-performance-scale-and-physical-performance-test-in-elderly-cancer-patients
#18
Marwan Ghosn, Tony Ibrahim, Elie El Rassy, Najib Nassani, Sassine Ghanem, Tarek Assi
OBJECTIVES: Comprehensive geriatric assessment (CGA) is a complex and interdisciplinary approach to evaluate the health status of elderly patients. The Karnofsky Performance Scale (KPS) and Physical Performance Test (PPT) are less time-consuming tools that measure functional status. This study was designed to assess and compare abridged geriatric assessment (GA), KPS and PPT as predictive tools of mortality in elderly cancer patients. MATERIALS AND METHODS: This prospective interventional study included all individuals aged >70years who were diagnosed with cancer during the study period...
December 7, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27743848/impact-of-chemotherapy-on-medium-term-physical-function-and-activity-of-older-breast-cancer-survivors-and-associated-biomarkers
#19
Martine Extermann, Christiaan Leeuwenburgh, Laila Samiian, Marina Sehovic, Jinze Xu, Christopher Cubitt, Paul B Jacobsen, Marco Pahor, Stephen R Grobmyer, Todd M Manini
OBJECTIVE: Chemotherapy is less often prescribed in older individuals due to concerns about post-treatment morbidity and quality of life. We evaluated the physical performance of breast cancer survivors treated with and without adjuvant chemotherapy. MATERIALS AND METHODS: We conducted a case-control study in 56 estrogen receptor positive breast cancer survivors (BCS) on adjuvant aromatase inhibitors 1-2years after definitive surgery. Cases had received adjuvant chemotherapy (n=27; age 70...
January 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27720129/increased-acute-mortality-with-chemoradiotherapy-for-locally-advanced-head-and-neck-cancer-in-patients-%C3%A2-70years
#20
Tobin J Strom, Arash O Naghavi, Andy M Trotti, Jeffery Russell, Julie A Kish, Judith McCaffrey, Kristen J Otto, Louis B Harrison, Jimmy J Caudell
PURPOSE: Concurrent chemoradiotherapy (CRT) is the standard of care for many sites of locally advanced head and neck squamous cell carcinomas (LAHNC). However, on meta-analysis, the addition of chemotherapy did not improve survival for patients >70years. We hypothesized that elderly patients treated with CRT would have increased toxicity without similar improvements in survival. METHODS: A single-institution, IRB-approved retrospective study took place from 2005 to 2012 including 369 patients treated with CRT for LAHNC...
January 2017: Journal of Geriatric Oncology
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