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Journal of Geriatric Oncology

Leigha Rowbottom, Allison Loucks, Rana Jin, Henriette Breunis, Ali Taqi Syed, Sarah Watt, Narhari Timilshina, Martine Puts, Daniel Yokom, Arielle Berger, Shabbir M H Alibhai
PURPOSE: Geriatric assessment (GA) is recommended for older adults ≥ 70 years with cancer to guide treatment selection. Screening tools such as the Vulnerable Elders Survey (VES-13) and G6 have been used to identify patients at highest need of GA. Whether either tool predicts a change in oncologic treatment following GA is unclear. METHODS: Patients attending a geriatric oncology clinic between July 2015 and June 2017 who completed a VES-13 and underwent subsequent GA were included...
November 9, 2018: Journal of Geriatric Oncology
Alina Mihai, Michael Milano, Ana Santos, Anne Marie Kennedy, Pierre Thirion, Luke Rock, Jennifer Westrup, Raymond McDermott, John G Armstrong
AIM: This is a retrospective single-institution review of the treatment completion and clinical outcomes of patients aged 75 and older, treated with stereotactic ablative body radiotherapy (SABR) for T1-T3 N0 M0 non-small cell lung cancer (NSCLC). MATERIAL: <AbstractText Label="METHODS" NlmCategory="METHODS">From April 2008 to September 2015, 200 patients, aged 75-93, received respiratory-managed, intensity-modulated-based SABR. Dose fractionation was risk-adapted and delivered in 2-3 weekly treatments...
November 9, 2018: Journal of Geriatric Oncology
Tarek Assi, Ziad Bakouny, Chris Labaki, Elie El Rassy, Aline Khazzaka, Rita Jabbour, Fady Ghassan Haddad, Aline Tohme, Fadi El Karak, Marwan Ghosn, Joseph Kattan
OBJECTIVES: To assess the causes of death (COD) in old patients with cancer (OPC). Determining the actual COD could have an impact on disease management and could guide future research in the field. METHODS: This is a retrospective study conducted at Hotel-Dieu de France University Hospital in Beirut, Lebanon. The Lebanese OPC (above 65 years of age) who died at our institution between the 1st of January 2012 and the 31st of December 2015 were included in this analysis...
October 31, 2018: Journal of Geriatric Oncology
Maria Pisu, Gabrielle B Rocque, Bradford E Jackson, Kelly M Kenzik, Pradeep Sharma, Courtney P Williams, Elizabeth A Kvale, Richard A Taylor, Grant R Williams, Andres Azuero, Yufeng Li, Aras Acemgil, Michelle Y Martin, Wendy Demark-Wahnefried, Yasemin Turkman, Mona Fouad, Rodney P Rocconi, Margaret Sullivan, Guilherme Cantuaria, Edward E Partridge, Karen Meneses
OBJECTIVES: The Patient Care Connect Program (PCCP), through lay navigators' distress assessments and assistance, was shown to lower healthcare utilization and costs in older cancer survivors. PCCP benefits and assistance needs for disadvantaged minorities (e.g., Black) vs. Whites are unknown. MATERIALS AND METHODS: We examined the PCCP impact with retrospective analyses of Medicare claims (2012-2015). Outcomes were quarterly costs and utilization (emergency room (ER), hospitalizations) for navigated and matched survivors...
October 30, 2018: Journal of Geriatric Oncology
Bahar Saberzadeh-Ardestani, Bardia Khosravi, Jayran Zebardast, Sanambar Sadighi
OBJECTIVES: The objective of this study was to determine the prevalence of excessive daytime sleepiness (EDS) among older Iranian patients with cancer and to analyze the effect of chemotherapy treatment on patients' sleep problems. The relationship between sleep disturbances and physical activity, psychological factors, and demographic data, are also explored. METHODS: This cross-sectional study consisted of interviews with 83 patients, >60 years old with a solid tumor, carried out in Cancer Institute of Iran once prior to receiving chemotherapy and the second time after the first cycles of chemotherapy...
October 27, 2018: Journal of Geriatric Oncology
Natalia Asimakopoulou, John Souglakos, Nikolaos Kentepozidis, Athanasios Karampeazis, Athanasios Kotsakis, Nikolaos Ziras, Paris Makrantonakis, Efthimios Prinarakis, Lambros Vamvakas, Vassilis Georgoulias
BACKGROUND: Although colorectal cancer (CRC) is a disease of the older patients, older patients are under-represented from randomized trials. Herein we conducted a retrospective analysis for the effect of panitumumab in the management of older patients (≥65 years) patients with metastatic CRC (mCRC) in the Hellenic Oncology Research Group's (HORG) database. METHODS: Τhe efficacy of panitumumab-based chemotherapy as front-line treatment in older patients with mCRC was assessed...
October 23, 2018: Journal of Geriatric Oncology
Linda M Pak, Tingsong Yang, Jiping Wang
OBJECTIVE: The safety of minimally-invasive (MIG) and open gastrectomy (OG) in the older patients has been demonstrated in several international studies but has not been evaluated in the context of a large, Western population. The objective of this study was to evaluate the safety of gastrectomy by these two approaches among octogenarians in the United States. MATERIALS AND METHODS: The National Cancer Database (2010-2014) was queried for patients with gastric adenocarcinoma who underwent MIG or OG...
October 23, 2018: Journal of Geriatric Oncology
Ashley Albert, Anna Lee, Robert Allbright, Srinivasan Vijayakumar
PURPOSE: Disparities in the receipt of standard of care based on age have been identified for several types of cancer including cervical cancer. The purpose of this study is to analyze patterns of care and survival for older patients receiving definitive treatment in a large, national cohort. MATERIALS AND METHODS: The National Cancer Database was queried for patients with FIGO/AJCC IB2-IVA cervical cancer diagnosed from 2004 to 2014 who underwent definitive radiation or concurrent chemoradiation...
October 22, 2018: Journal of Geriatric Oncology
Kerri M Winters-Stone, Mary E Medysky, Michael A Savin
OBJECTIVES: Older breast cancer survivors (BCS) consistently report more functional limitations than women without cancer, but whether or not these differences remain when using objective measures of physical functioning and the correlates of these measures is unknown. METHODS: Cross-sectional study comparing older (≥60 years old) BCS (n = 84) to similarly aged women without cancer (n = 40). Patient-reported physical function was assessed by the SF-36 physical function (SF-36PF) subscale and the Late Life Function & Disability Instrument (LLFDI)...
October 18, 2018: Journal of Geriatric Oncology
Grant R Williams, Hánah N Rier, Andrew McDonald, Shlomit S Shachar
No abstract text is available yet for this article.
October 18, 2018: Journal of Geriatric Oncology
Gabor Liposits, Kah Poh Loh, Enrique Soto-Perez-de-Celis, Lucy Dumas, Nicolò Matteo Luca Battisti, Sindhuja Kadambi, Capucine Baldini, Susana Banerjee, Stuart M Lichtman
Breast and ovarian cancer are common malignancies among older adults, causing significant morbidity and mortality. Although most cases of breast and ovarian cancer are sporadic, a significant proportion is caused by mutations in cancer susceptibility genes, most often breast cancer susceptibility genes (BRCA) 1 and 2. Furthermore, some breast and ovarian tumors are phenotypically similar to those with BRCA mutations, a phenomenon known as "BRCAness". BRCA mutations and "BRCAness" lead to defects in DNA repair, which may be a target for therapeutic agents such as Poly ADP-Ribose Polymerase (PARP) inhibitors...
October 14, 2018: Journal of Geriatric Oncology
Lorenzo Dottorini, Laura Catena, Italo Sarno, Giandomenico Di Menna, Annamaria Marte, Eugenio Novelli, Carmen Rusca, Emilio Bajetta
BACKGROUND: Endocrine therapy is the main treatment in hormonosensitive breast cancer; the most frequent side effects are arthralgia, osteoporosis, depression, dyslipidemia and hypertension. G8 is a simple test developed to identify older patients who could benefit from a comprehensive geriatric assessment (CGA). The aim of this study is to evaluate the possible role of G8 in predicting side effects from treatment with aromatase inhibitor in women ≥65 years old. MATHERIAL AND METHOD: Women ≥65 years old affected by breast cancer about to start a therapy with an aromatase inhibitor, in the adjuvant setting, were evaluated with the G8 tool...
October 14, 2018: Journal of Geriatric Oncology
Marlid Cruz-Ramos, Laura Del Puerto-Nevado, Binbin Zheng, Rafael López-Bajo, Arancha Cebrian, María Rodríguez-Remirez, Laura García-García, Sonia Solanes-Casado, Jesús García-Foncillas
Aging is associated with a higher risk of cancer, >70% of cancer-related deaths occur in aged patients; however, this population is underrepresented in clinical trials, therefore, clinical information regarding this age group is rather limited. OBJECTIVES: Neutrophil-to lymphocyte ratio (NLR) and platelet-to lymphocyte ratio (PLR) have been described as biomarkers in cancer, thus, we have assessed their impact in an aged cohort of patients with metastatic colorectal cancer (mCRC). PATIENTS AND METHODS: 110 patients with a mean age of 72...
October 13, 2018: Journal of Geriatric Oncology
Mehdi Naderi, Siamak Sabour
No abstract text is available yet for this article.
October 11, 2018: Journal of Geriatric Oncology
Jordan Doherty, David E Dawe, Gregory R Pond, Peter M Ellis
OBJECTIVES: Small cell lung cancer (SCLC) represents a significant health burden. There is a lack of information about patterns of referral and treatment for older patients over 70 years of age, in comparison to younger patients with SCLC. MATERIALS AND METHODS: A population-based retrospective cohort study was undertaken for patients identified from the Ontario Cancer Registry, Canada. All cases of SCLC diagnosed between January 2000 and December 2010 were eligible...
October 11, 2018: Journal of Geriatric Oncology
Valentina Lancellotta, Gyoergy Kovács, Luca Tagliaferri, Elisabetta Perrucci, Agata Rembielak, Luca Stingeni, Marta Tramontana, Katharina Hansel, Giuseppe Colloca, Simonetta Saldi, Vincenzo Valentini, Cynthia Aristei
OBJECTIVE: Non-melanoma skin cancer (NMSC) has been rapidly increasing in incidence over the past 30 years. Mainstays of treatment remain surgery and radiotherapy, particularly in older and/or frail patients (≥75 years old) that often require a personalized treatment strategy using innovative biotechnologies. High-dose-rate interventional radiotherapy (HDR-IRT) seems to be an excellent option for NMSC. MATERIAL AND METHODS: Nineteen aged patients with advanced, biopsy proven NMSC were treated with exclusively HDR-IRT...
October 9, 2018: Journal of Geriatric Oncology
Barbara Deschler, Gabriele Ihorst, Michael Hüll, Peter Baier
AIMS: The effectiveness of surgery depends on it being carried out safely, which allows patients to return to independent lives. Because gastrointestinal cancers are a major cause of morbidity and mortality in older people, we examined the dynamics of recuperation after elective, curative surgery. As disease parameters alone may not suffice to address geriatric patients' issues after onco-surgical interventions, Comprehensive Geriatric and QOL Assessments (CGA/QOL) were performed at four time points to gain information on clinical, functional, and cognitive aspects...
October 9, 2018: Journal of Geriatric Oncology
Lore Decoster, Denis Schallier
With a median age of 70 years at diagnosis, lung cancer is a disease of older persons. As a consequence oncologists are confronted with an increasing older lung cancer population for which treatment decisions are needed. In the past years, the therapeutic landscape of advanced non-small cell lung cancer (NSCLC) has changed impressively with the introduction of targeted therapies and immunotherapy next to chemotherapy. Treatment choices for advanced NSCLC are mainly guided by different tumor-related characteristics...
October 6, 2018: Journal of Geriatric Oncology
Marco Radovic, Ravindran Kanesvaran, Achim Rittmeyer, Martin Früh, Fabrizio Minervini, Markus Glatzer, Paul Martin Putora
Lung cancer is the leading cause of cancer death worldwide. Older patients represent approximately half of the patient population and optimal management of these patients is challenging. In early-stagenon-small cell lung cancer (NSCLC), lobectomy should be considered in fit older patients. For unfit patients, stereotactic body radiotherapy (SBRT) represents a good alternative. While data on the benefit and risk of concurrent chemo-radiotherapy (cCRT) in older patients with locally advanced NSCLC is conflicting, age alone should not preclude cCRT...
October 3, 2018: Journal of Geriatric Oncology
Christopher D Saffore, Naomi Y Ko, Holly M Holmes, Pritesh R Patel, Karen Sweiss, Sruthi Adimadhyam, Brian C-H Chiu, Gregory S Calip
No abstract text is available yet for this article.
September 27, 2018: Journal of Geriatric Oncology
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