journal
https://read.qxmd.com/read/38538494/an-analysis-of-psychological-problems-in-older-indian-patients-with-cancer
#1
JOURNAL ARTICLE
Anita Kumar, Lekhika Sonkusare, Vanita Noronha, Jayita Deodhar, Abhijith Rajaram Rao, Sharath Kumar, Renita Castellino, Shreya Gattani, Ratan Dhekale, Jyoti Krishnamurthy, Sarika Mahajan, Anuradha Daptadar, Nabila Ansari, Manusha Vagal, Vikram Gota, Purabi Mahajan, Manjunath Nookala, Ankita Chitre, Shripad Banavali, Kumar Prabhash, Rajendra Badwe, Anant Ramaswamy
No abstract text is available yet for this article.
March 26, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38521641/toward-a-comprehensive-supportive-care-intervention-for-older-men-with-metastatic-prostate-cancer-topcop3-a-pilot-randomized-controlled-trial-and-process-evaluation
#2
JOURNAL ARTICLE
Shabbir M H Alibhai, Martine Puts, Rana Jin, Kian Godhwani, Maryjo Antonio, Soha Abdallah, Gregory Feng, Monika K Krzyzanowska, Enrique Soto-Perez-de-Celis, Efthymios Papadopoulos, Calvin Mach, Ferozah Nasiri, Srikala S Sridhar, Rachel Glicksman, Lesley Moody, Jacqueline Bender, Hance Clarke, Andrew Matthew, Dennis McIntosh, Winston Klass, Urban Emmenegger
INTRODUCTION: Current management of metastatic prostate cancer (mPC) includes androgen receptor axis-targeted therapy (ARATs), which is associated with substantial toxicity in older adults. Geriatric assessment and management and remote symptom monitoring have been shown to reduce toxicity and improve quality of life in patients undergoing chemotherapy, but their efficacy in patients being treated with ARATs has not been explored. The purpose of this study is to examine whether these interventions, alone or in combination, can improve treatment tolerability and quality of life (QOL) for older adults with metastatic prostate cancer on ARATs...
March 22, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38513534/-a-strong-reason-why-i-enjoy-coming-to-work-clinician-acceptability-of-a-palliative-and-supportive-care-intervention-pact-for-older-adults-with-acute-myeloid-leukemia-and-their-care-partners
#3
JOURNAL ARTICLE
Ayomide Okanlawon Bankole, Natasha Renee Burse, Victoria Crowder, Ya-Ning Chan, Rachel Hirschey, Ahrang Jung, Kelly R Tan, Susan Coppola, Mackenzi Pergolotti, Daniel R Richardson, Ashley Leak Bryant
INTRODUCTION: Studies about clinician acceptability of integrative palliative care interventions in the inpatient and outpatient cancer settings are limited. In this study, we examined clinician acceptability of a NIH-funded interdisciplinary PAlliative and Supportive Care inTervention (PACT) for older adults with acute myeloid leukemia (AML) and their care partners that transcends both inpatient and outpatient settings. MATERIALS AND METHODS: Data was collected using semi-structured interviews with clinicians who were directly involved in PACT...
March 20, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38513310/racial-differences-in-body-composition-and-survival-among-older-adults-with-gastrointestinal-malignancies
#4
JOURNAL ARTICLE
Gabriel F P Aleixo, Daniel L Hess, Mackenzie E Fowler, Smith Giri, Grant R Williams
INTRODUCTION: Muscle and adipose tissue measures can be quantified from routinely obtained computed tomography (CT) images and are predictors of chemotherapy-related toxicities and survival among patients with gastrointestinal (GI) malignancies. Most studies to date have consisted of predominantly White patients, and the role of body composition among minoritized racial groups is unknown. We examined racial differences in body composition and survival among patients with GI malignancies...
March 20, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38493533/association-of-race-ethnicity-and-patient-care-experiences-with-healthcare-utilization-and-healthcare-costs-among-prostate-cancer-survivors-a-seer-cahps-study
#5
JOURNAL ARTICLE
Ambrish A Pandit, Michael T Halpern, Laura E Gressler, Mohamed Kamel, Nalin Payakachat, Chenghui Li
INTRODUCTION: This study aimed to evaluate the association of race/ethnicity and patient care experiences (PCEs) with healthcare utilization and costs among US older adults with prostate cancer (PCa). MATERIALS AND METHODS: The study used data from 2007 to 2015 Surveillance, Epidemiology, and End Results dataset linked to Medicare Consumer Assessment of Healthcare Providers and Systems survey and Medicare claims (SEER-CAHPS). We identified males aged ≥65 years who completed a CAHPS survey within 6-60 months post-PCa diagnosis...
March 16, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38492350/evaluation-of-treatment-outcomes-and-tolerability-in-older-patients-with-rectal-cancer-treated-with-radiotherapy-accompanied-by-the-g-8-geriatric-score-trod13-003-multicenter-study
#6
JOURNAL ARTICLE
Zeliha Güzelöz, İlknur Bilkay Görken, Barbaros Aydın, Fatma Sert, Deniz Yalman, Murtaza Parvizi, Gülhan Güler Avcı, Pelin Altınok, Hatice Halis, Şefika Arzu Ergen, Züleyha Akgün, Elif Özkan, Yıldız Güney, Didem Karaçetin, Nuri Kaydıhan, Mürsel Düzova, Murat Akın, Bora Uysal, Mihriban Erdoğan, Hülya Ellidokuz, Gamze Aksu, Evrim Metcalfe
INTRODUCTION: The choice of treatment for rectal cancer often differs in older and younger patients, with the rate of radiotherapy use lower among older adults. In our daily practice, when evaluating a frail older patient with rectal cancer, we usually choose to give less treatment. This may be due to concern that the patient will not be able to tolerate radiotherapy. The Geriatric 8 score (G8GS) is a guide to evaluating treatment tolerability as it relates to frailty in older adults with cancer...
March 15, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38490916/words-matter-use-caution-when-interpreting-study-s-results
#7
JOURNAL ARTICLE
Sophie Pilleron
We read the study of Bhatt and colleagues titled "Longitudinal changes in cognitive and physical function and health-related quality of life in older adults with acute myeloid leukaemia" published in Journal of Geriatric Oncology in January 2024. We commented in regards to the importance of the wording to be used when interpreting the results of research studies.
March 14, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38490915/receipt-of-financial-assistance-for-oral-targeted-therapy-among-older-adults-with-advanced-non-small-cell-lung-cancer-a-prospective-cohort-study
#8
JOURNAL ARTICLE
Anika Kumar, Meera Ragavan, Ana I Velazquez, Sandra Zeng, Melisa L Wong
No abstract text is available yet for this article.
March 14, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38490100/older-patients-experiences-with-and-attitudes-towards-an-oncogeriatric-pathway-a-qualitative-study
#9
JOURNAL ARTICLE
Anna Uit den Boogaard, Dide de Jongh, Marjan J T van den Elst, Stella Trompet, Janneke M de Man-van Ginkel, Johanneke E A Portielje, Yvette Meuleman, Simon P Mooijaart, Nienke A de Glas, Frederiek van den Bos
INTRODUCTION: To tailor treatment for older patients with cancer, an oncogeriatric care pathway has been developed in the Leiden University Medical Center. In this care pathway a geriatric assessment is performed and preferences concerning cancer treatment options are discussed. This study aimed to explore patient experiences with and attitudes towards this pathway. MATERIALS AND METHODS: A qualitative study was performed using an exploratory descriptive approach...
March 14, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38472009/immunotherapy-use-in-older-adults-with-cancer-with-frailty-a-young-siog-review-paper
#10
REVIEW
Deniz Can Guven, Bertha Alejandra Martinez-Cannon, Giuseppe Dario Testa, Janine Capobiango Martins, Rogelio N Velasco, Tania Kalsi, Fabio Gomes
Immune checkpoint inhibitors (ICIs) became a treatment option in most tumor types and improved survival in patients with cancer in the last decade. Older patients with cancer are underrepresented in the pivotal clinical trials with ICIs. Older patients with cancer often have significant comorbidities and geriatric syndromes like frailty, which can complicate cancer care and treatment decisions. Frailty is among the most prevalent geriatric syndromes in patients with cancer and could lead to inferior survival and a higher risk of complications in patients treated with chemotherapy...
March 11, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38462434/immune-checkpoint-inhibitor-doublets-are-they-beneficial-for-older-patients-a-systematic-review-and-meta-analysis
#11
REVIEW
Lorenzo Dottorini, Antonio Ghidini, Rita Deda, Italo Sarno, Matteo Cavallone, Andrea Luciani, Fausto Petrelli
INTRODUCTION: The introduction of immune checkpoint inhibitors (ICIs) has significantly transformed the treatment landscape for advanced malignancies. These inhibitors bolster the immune system's capacity to detect and destroy cancer cells. ICIs used in cancer immunotherapy are primarily categorized into two groups: anti-PD-1/L1 and anti-CTLA-4. The application of combination ICI therapy (ICI doublets) in older patients prompts questions about their relative efficacy compared to standard therapies, particularly in comparison to younger patient cohorts...
March 9, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38461641/statin-use-in-older-adults-with-cancer-experience-from-a-dedicated-geriatric-oncology-service
#12
JOURNAL ARTICLE
Darragh T O'Sullivan, Darren J Walsh, Caitriona Goggin, Anne M Horgan
INTRODUCTION: The increase in statin use, since their introduction, has been rapid and the broadening of indications has occurred seemingly without restriction. Once established on statin therapy, there is sparse research on discontinuation. Trials do not often address benefit in later life, or the impact of a life-limiting diagnosis. Data on primary prevention suggest that 100 patients need treatment for 2.5 years to prevent one major adverse cardiovascular event. Acknowledging this, we sought to determine the use of statins in a cohort of older adults with cancer, to highlight prevalence, and suggest a role for deprescribing...
March 9, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38461116/survival-outcomes-in-older-adults-undergoing-early-phase-clinical-trials
#13
JOURNAL ARTICLE
Udit Nindra, Sarah Childs, Robert Yoon, Sana Haider, Martin Hong, Aflah Roohullah, Adam Cooper, Kate Wilkinson, Abhijit Pal, Wei Chua
No abstract text is available yet for this article.
March 8, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38461115/advance-care-planning-among-older-adults-with-cancer-in-the-united-states-findings-from-the-national-health-and-aging-trends-study
#14
JOURNAL ARTICLE
Weijiao Zhou, Shaomei Shang, Youmin Cho
No abstract text is available yet for this article.
March 8, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38460399/a-structured-oral-chemotherapy-teaching-tool-to-improve-adherence-in-adults-with-multiple-myeloma-a-pilot-randomized-controlled-trial
#15
JOURNAL ARTICLE
Imran Haider, Gregory R Pond, Ruthanne Cameron, Mohammed Aljama, Tom C Kouroukis, Kirk Wong, Mark A Fiala, Tanya M Wildes, Hira Mian
INTRODUCTION: Many of the newer treatments for adults with newly-diagnosed and relapsed multiple myeloma (MM) are orally administered. Adherence is a challenge, and little is known about strategies to optimize adherence. MATERIALS AND METHODS: Forty-seven patients initiating orally-administered anti-myeloma therapy were enrolled and randomized in a pilot study to receive either standard of care teaching or the Multinational Association of Supportive Care in Cancer Oral agent Teaching Tool (MOATT), a structured teaching tool...
March 8, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38430810/cellular-therapies-in-older-adults-with-hematological-malignancies-a-case-based-state-of-the-art-review
#16
JOURNAL ARTICLE
Nina Rosa Neuendorff, Abdullah Khan, Fabian Ullrich, Samuel Yates, Srinivas Devarakonda, Richard J Lin, Bastian von Tresckow, Raul Cordoba, Andrew Artz, Ashley E Rosko
Cellular therapies, including autologous stem cell transplant (ASCT), allogeneic hematopoietic cell transplantation (alloHCT), and chimeric antigen receptor- (CAR-) T cell therapies are essential treatment modalities for many hematological malignancies. Although their use in older adults has substantially increased within the past decades, cellular therapies represent intensive treatment approaches that exclude a large percentage of older adults due to comorbidities and frailty. Under- and overtreatment in older adults with hematologic malignancy is a challenge and many treatment decisions are influenced by chronologic age...
February 29, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38428186/assessing-frailty-in-older-indian-patients-before-cancer-treatment-comparative-analysis-of-three-scales-and-their-implications-for-overall-survival
#17
JOURNAL ARTICLE
Abhijith R Rao, Vanita Noronha, Anant Ramaswamy, Anita Kumar, Anupa Pillai, Arshiya Sehgal, Renita Castelino, Ratan Dhekale, Pravin Jagtap, Vinod Tripathi, Sunita Satamkar, Jyoti Krishnamurthy, Sarika Mahajan, Anuradha Daptardar, Lekhika Sonkusare, Jayita Deodhar, Nabila Ansari, Manjusha Vagal, Purabi Mahajan, Shivshankar Timmanpyati, Manjunath Nookala, Ankita Chitre, Akhil Kapoor, Vikram Gota, Shripad Banavali, Rajendra A Badwe, Kumar Prabhash
INTRODUCTION: Frailty, characterized by ageing-related vulnerability, influences outcomes in older adults. Our study aimed to investigate the relationship between frailty and clinical outcomes in older Indian patients with cancer. MATERIALS AND METHODS: Our observational single-centre study, conducted at Tata Memorial Hospital from February 2020 to July 2022, enrolled participants aged 60 years and above with cancer. Frailty was assessed using the Clinical Frailty Scale (CFS), G8, and Vulnerable Elders Survey (VES)-13...
February 29, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38360455/trends-in-wearable-device-use-among-cancer-survivors-in-the-united-states-from-2019-to-2022
#18
JOURNAL ARTICLE
Weijiao Zhou, Youmin Cho, Junlan Pu, Shaomei Shang
No abstract text is available yet for this article.
February 14, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38359528/do-older-patients-with-colorectal-cancer-experience-more-deterioration-in-health-related-quality-of-life-than-younger-patients-during-the-first-year-of-palliative-chemotherapy-a-prospective-real-world-observational-study
#19
JOURNAL ARTICLE
Ingunn Hatlevoll, Are K Kristensen, Tora S Solheim, Hege Elvebakken, Øyvind Salvesen, Line M Oldervoll, Arne Wibe, Eva Hofsli
INTRODUCTION: The primary aim was to evaluate changes in health-related quality of life (HRQoL) in a real-life population among younger (< 70 years) and older patients with metastatic colorectal cancer (mCRC) during the first year of palliative chemotherapy. The secondary aims were to assess the impact of chemo-break on HRQoL and to report overall survival (OS). MATERIALS AND METHODS: Patients with newly diagnosed mCRC, ≥ 18 years, and scheduled for first line palliative chemotherapy were included in this multicentre longitudinal observational study...
February 14, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38350343/understanding-the-incidence-duration-and-severity-of-symptoms-through-daily-symptom-monitoring-among-frail-and-non-frail-older-patients-receiving-metastatic-prostate-cancer-treatments
#20
JOURNAL ARTICLE
Milothy Parthipan, Gregory Feng, Henriette Breunis, Narhari Timilshina, Urban Emmenegger, Aaron Hansen, George Tomlinson, Andrew Matthew, Hance Clarke, Daniel Santa Mina, Enrique Soto-Perez-de-Celis, Martine Puts, Shabbir M H Alibhai
INTRODUCTION: Older adults with metastatic prostate cancer (mPC) experience high symptom burden associated with treatment. Frailty may exacerbate treatment toxicity. The aim of this study was to explore short-term treatment toxicity in patients with metastatic prostate cancer. MATERIALS AND METHODS: Older adults with metastatic prostate cancer starting chemotherapy, androgen-receptor-axis targeted therapies, or radium-223 participated in a prospective, multicentre, observational study...
February 12, 2024: Journal of Geriatric Oncology
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