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Journal of Geriatric Oncology

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https://www.readbyqxmd.com/read/29030150/sociodemographic-socioeconomic-and-clinical-determinants-of-survival-in-patients-with-cancer-a-systematic-review-of-the-literature-focused-on-the-elderly
#1
REVIEW
Angéline Galvin, Fleur Delva, Catherine Helmer, Muriel Rainfray, Carine Bellera, Virginie Rondeau, Pierre Soubeyran, Gaëlle Coureau, Simone Mathoulin-Pélissier
Studies on cancer survival have revealed disparities not only between the elderly and their younger counterparts, but also among the elderly themselves. The aim of this work was to identify sociodemographic, socioeconomic, clinical, and care-related determinants of survival or mortality in older patients with cancer by a systematic synthesis of the literature. Understanding these factors is of great value for guiding health policies and programs aimed at reducing cancer survival disparities. We conducted a search of MEDLINE and SCOPUS databases under PRISMA guidelines...
October 10, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29032962/the-impact-of-postoperative-complications-on-health-related-quality-of-life-in-older-patients-with-rectal-cancer-a-prospective-cohort-study
#2
Alice M Couwenberg, Fleur S A de Beer, Martijn P W Intven, Johannes P M Burbach, Anke B Smits, Esther C J Consten, Anandi H W Schiphorst, Niels A T Wijffels, Marnix A J de Roos, Marije E Hamaker, Wilhemina M U van Grevenstein, Helena M Verkooijen
OBJECTIVES: As result of the aging population and increasing rectal cancer incidence, more older patients undergo treatment for rectal cancer. This study compares treatment course, postoperative complications, and quality of life (QOL) between older and younger patients with rectal cancer and evaluates the impact of postoperative complications on QOL in the elderly. MATERIALS AND METHODS: Patients with rectal cancer participating in a prospective colorectal cancer cohort and referred for radiotherapy between 2013 and 2016 were included...
October 9, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29017891/a-pilot-study-of-an-accelerometer-equipped-smartphone-to-monitor-older-adults-with-cancer-receiving-chemotherapy-in-mexico
#3
Enrique Soto-Perez-De-Celis, Heeyoung Kim, María Patricia Rojo-Castillo, Can-Lan Sun, Yanin Chavarri-Guerra, Ana Patricia Navarrete-Reyes, James R Waisman, José Alberto Avila-Funes, Álvaro Aguayo, Arti Hurria
OBJECTIVES: Older adults with cancer in developing countries face challenges accessing healthcare due to a lack of personnel and infrastructure. A decline in physical activity (defined as a decrease in the number of daily steps) may be a novel method for the timely detection of toxicity in older adults receiving chemotherapy in resource-constrained settings. MATERIALS AND METHODS: In this feasibility study, patients aged ≥65years starting first-line chemotherapy for solid tumors were given a smartphone with a pedometer application...
October 7, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28988631/necessity-of-d2-lymph-node-dissection-in-older-patients-%C3%A2-80years-with-gastric-cancer
#4
Ho Seok Seo, Yoon Ju Jung, Ji Hyun Kim, Cho Hyun Park, Han Hong Lee
OBJECTIVES: This study analyzed the effect of D2 lymph node (LN) dissection on complications and survival in older patients with gastric cancer. MATERIALS AND METHODS: A total of 103 octogenarian patients who underwent curative gastrectomy for gastric cancer were divided into two groups (D2 and D1) according to the extent of LN dissection and analyzed retrospectively for complications and survival. RESULTS: No differences were observed in short-term postoperative outcomes, including complication rates, between the two groups...
October 4, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28978411/in-memory-of-claude-jasmin-a-prophet-of-geriatric-oncology
#5
EDITORIAL
Lodovico Balducci
No abstract text is available yet for this article.
October 1, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28958666/pearls-of-optimizing-nutrition-and-physical-performance-of-older-adults-undergoing-cancer-therapy
#6
Antonio Vigano, Popi Kasvis, Jonathan Di Tomasso, Chelsia Gillis, Robert Kilgour, Franco Carli
As the global population continues to age, the prevalence of cancer is increasing, with more than half of new cancer diagnoses occurring in those aged 65years and older. As a result of improved oncological care, a greater number of older patients undergo treatment, either chemoradiotherapy or surgery or both. The older oncology patient is not part of a homogenous group; chronological age poorly describes the health status of an individual. Comprehensive geriatric assessment (CGA) identifies domains, assessed by a multidisciplinary team, that should be considered to guide appropriate oncological treatment decisions...
September 22, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28958665/the-siog-treviso-course-students-perspective
#7
Cecilia M Lund, Shane O'Hanlon
No abstract text is available yet for this article.
September 22, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28941581/use-of-frailty-to-predict-survival-in-elderly-patients-with-early-stage-non-small-cell-lung-cancer-treated-with-stereotactic-body-radiation-therapy
#8
Idalid Franco, Yu-Hui Chen, Fallon Chipidza, Vishesh Agrawal, John Romano, Elizabeth Baldini, Aileen Chen, Yolonda Colson, Ying Hou, David Kozono, Jon Wee, Raymond Mak
OBJECTIVES: Frailty has been shown to increase morbidity and mortality independent of age, but studies are lacking in radiation oncology. This study evaluates a modified frailty index (mFI) in predicting overall survival (OS) and non-cancer death for Stage I/II [N0M0] Non-Small-Cell Lung Cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT). MATERIALS AND METHODS: Medical records for all patients with Stage I/II NSCLC treated at our institution with SBRT from 2009 to 2014 were reviewed...
September 20, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28939384/are-prostate-biopsies-necessary-for-all-patients-75years-and-older
#9
Yuke Chen, Yu Fan, Yang Yang, Jie Jin, Liqun Zhou, Zhisong He, Zheng Zhao, Qun He, Xiaoying Wang, Wei Yu, Shiliang Wu
PURPOSE: To develop nomograms predicting prostate cancer (PCa) and high-grade PCa (HGPCa) in the elderly population. METHODS: We reviewed the data of patients aged 75years and older who underwent first-time prostate biopsy and multiparametric magnetic resonance imaging (mpMRI). The nomograms were developed based on multivariate analysis and evaluated. We performed the external validation and calibration of the risk calculators from the European Randomized Study of Screening for Prostate Cancer (ERSPC) and the Prostate Cancer Prevention Trial (PCPT)...
September 19, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28927748/the-oldest-old-within-the-comprehensive-home-palliative-care-program-of-the-ant-foundation-in-italy-for-advanced-cancer-patients
#10
LETTER
Andrea A Martoni, Brunella Boltri, Elena Strocchi, Franco Pannuti
No abstract text is available yet for this article.
September 15, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28917648/challenges-of-conducting-a-prospective-clinical-trial-for-older-patients-lessons-learned-from-ncctg-n0949-alliance
#11
Nadine J McCleary, Joleen Hubbard, Michelle R Mahoney, Jeffrey A Meyerhardt, Daniel Sargent, Alan Venook, Axel Grothey
OBJECTIVES: While the risk of developing colorectal cancer increases with age, there are limited prospective data regarding best treatment in the older adult population. We launched a phase III trial to evaluate difference in treatment outcome for older adults (aged ≥70years) with advanced colorectal cancer. Here we review the challenges faced and reasons for poor accrual to N0949. MATERIALS AND METHODS: We describe the conceptualization, development and limited results of N0949, a randomized phase III study of fluoropyrimidine/bevacizumab with or without oxaliplatin (mFOLFOX7 or XELOX) as first line chemotherapy for metastatic colorectal cancer...
September 13, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28919022/a-prospective-comparison-of-younger-and-older-patients-preferences-for-breast-conserving-surgery-versus-mastectomy-in-early-breast-cancer
#12
LETTER
Victoria C Hamelinck, Esther Bastiaannet, Arwen H Pieterse, Jos W S Merkus, Ilse Jannink, Irma D M den Hoed, Cornelis J H van de Velde, Gerrit-Jan Liefers, Anne M Stiggelbout
No abstract text is available yet for this article.
September 11, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28890328/are-phase-i-trials-safe-for-older-patients
#13
REVIEW
Capucine Baldini, Olivia Le Saux, Carole Helissey, Sandrine Aspeslagh, Eduardo Castanon, Andreea Varga, Anas Gazzah, Rastio Bahleda, Olivier Mir, Christophe Massard, Jean-Charles Soria, Antoine Hollebecque
Phase I clinical trials in oncology primarily aim to assess the toxicity profile of new drugs and determine recommended phase II doses (RP2D). Since the cancer rate increases with age and our population is continually aging, RP2D must necessarily be assessed in older patients. Few clinical studies include older patients, however, and particularly few Phase I trials. We reviewed published data on the safety and efficacy of Phase I trials in older patients. The majority of studies included primarily young, fit patients, with age thresholds varying widely from 65 to 80years...
September 7, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28888556/telehealth-in-older-adults-with-cancer-in-the-united-states-the-emerging-use-of-wearable-sensors
#14
REVIEW
John Shen, Arash Naeim
As the aging and cancer populations in the world continue to increase, the need for complements to traditional geriatric assessments and the logical incorporation of fast and reliable telehealth tools have become interlinked. In the United States, studies examining the use of telehealth for chronic disease management have shown promising results in small groups. The implementation of health technology on a broader scale requires older adults to both accept and adapt such innovation into routine medical care...
September 6, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28888555/functional-impairment-prior-to-major-non-cardiac-surgery-is-associated-with-mortality-within-one-year-in-elderly-patients-with-gastrointestinal-gynaecological-and-urogenital-cancer-a-prospective-observational-cohort-study
#15
Maren Schmidt, Rahel Eckardt, Sarah Altmeppen, Klaus-Dieter Wernecke, Claudia Spies
OBJECTIVE: To investigate the prognostic value of elements of the Geriatric Assessment, in particular the Timed Up and Go (TUG) Test and the Barthel Index of Activities of Daily Living (ADL) for one-year post-operative mortality in elderly patients with cancer. MATERIALS AND METHODS: This prospective cohort study included patients 65years of age or older undergoing elective major surgery for cancer between June 2008 and June 2010. Preoperative functional status was measured by the TUG Test and the Barthel Index of ADL Cognitive state was assessed by the Mini Mental State Examination (MMSE)...
September 6, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28888554/how-to-treat-pancreatic-adenocarcinoma-in-elderly-how-far-can-we-go-in-2017
#16
REVIEW
Marine Gilabert, Jean Luc Raoul, Frederique Rousseau
Pancreatic adenocarcinoma is one of the most fatal cancers that frequently affects older patients. Limited data suggest that older patients are as likely to benefit from surgery, radiation, and chemotherapy as younger patients. The only potentially curative approach for pancreatic cancer is surgery but this is only performed in less than 20% of patients considered resectable. With improvements in surgical techniques, older patients without major comorbidities show a course of disease after resection similar to that of younger patients...
September 6, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28888553/nutricancer-a-french-observational-multicentre-cross-sectional-study-of-malnutrition-in-elderly-patients-with-cancer
#17
Jean Lacau St Guily, Éric Bouvard, Bruno Raynard, François Goldwasser, Brigitte Maget, Alain Prevost, David Seguy, Olivier Romano, Bérengère Narciso, Charles Couet, Jean-Michel Balon, Damien Vansteene, Sébastien Salas, Philippe Grandval, Emmanuel Gyan, Xavier Hebuterne
OBJECTIVES: To compare the prevalence of malnutrition and nutritional management between elderly (≥70years old) and younger patients (<70years) with cancer. PATIENTS AND METHODS: This is a post-hoc analysis of NutriCancer 2012 study; a one-day cross-sectional nationwide survey conducted to assess malnutrition in adult patients with cancer in France. Patients diagnosed with cancer at the study date in both inpatient and outpatient settings were included. Data collection was performed by means of questionnaires completed by the physician, the patient and the caregiver...
September 6, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28887066/neoadjuvant-chemoradiation-is-associated-with-improved-overall-survival-in-older-patients-with-esophageal-cancer
#18
David M Guttmann, Nandita Mitra, James M Metz, John Plastaras, Weiwei Feng, Samuel Swisher-McClure
OBJECTIVES: The aim of this study was to characterize outcomes associated with neoadjuvant chemoradiation prior to esophagectomy, compared to esophagectomy alone, in older patients with esophageal cancer. MATERIALS AND METHODS: We conducted an observational cohort study in patients ≥70years with locally-advanced esophageal cancer undergoing esophagectomy ± neoadjuvant chemoradiation between 2006 and 2012 using the National Cancer Database. A Cox proportional hazards model with inverse probability of treatment weighting (IPTW) using the propensity score was developed to assess the association between trimodality therapy and overall survival...
September 5, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28877856/geriatric-cancer-trends-in-the-middle-east-findings-from-lebanese-cancer-projections-until-2025
#19
Fady G H Haddad, Joseph Kattan, Hampig R Kourie, Elie El Rassy, Tarek Assi, Salim M Adib
OBJECTIVE: By 2020, 70% of all cancers will occur in patients aged 65years and older, causing an increase in related morbidity, mortality, and cost. This study projects cancer trends in the elderly population in Lebanon, a country experiencing accelerating aging trends. Findings will guide future policy decisions regarding geriatric oncology in Lebanon and the surrounding Arab world. MATERIALS AND METHODS: Cancer incidence rates were derived for men and women 65years and above, divided into three age groups: 65-69years, 70-74years, and 75years and above...
September 4, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28867559/fighting-back-against-the-dilution-of-the-comprehensive-geriatric-assessment
#20
Martine T E Puts, Shabbir M H Alibhai
No abstract text is available yet for this article.
August 31, 2017: Journal of Geriatric Oncology
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