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Journal of Geriatric Oncology

Sira Laohathai, Sukki Cho, Sungwon Yum, Hyo Jun Jang, Yong Won Seong, Kwhanmien Kim, Sanghoon Jheon
No abstract text is available yet for this article.
September 16, 2018: Journal of Geriatric Oncology
Erin B Moth, Belinda E Kiely, Natalie Stefanic, Vasikaran Naganathan, Andrew Martin, Peter Grimison, Martin R Stockler, Philip Beale, Prunella Blinman
AIM: The Cancer and Aging Research Group's (CARG) Toxicity Score was designed to predict grade ≥3 chemotherapy-related toxicity in adults aged ≥65 yrs. commencing chemotherapy for a solid organ cancer. We aimed to evaluate the CARG Score and compare it to oncologists' estimates for predicting severe chemotherapy toxicity in older adults. METHODS: Patients aged ≥65 yrs. starting chemotherapy for a solid organ cancer had their CARG Score (range 0-23) calculated...
September 14, 2018: Journal of Geriatric Oncology
Joyita Banerjee, Sujata Satapathy, Ashish Dutt Upadhyay, Sada Nand Dwivedi, Prasun Chatterjee, Lalit Kumar, Goura Kishor Rath, Aparajit Ballav Dey
INTRODUCTION: With rise in incidence and prevalence of cancers in the ageing population, the need for an age sensitive comprehensive assessment measure has been felt. Comprehensive Geriatric Assessment (CGA) is often difficult to implement due to time and logistic constraints. A brief assessment tool encompassing the specific domains of the CGA would be a better way to assess older adults with cancer. These tools exist but have not necessarily been culturally adapted. The main aim of the study was to develop a culturally relevant short geriatric assessment tool and explore its psychometric properties...
September 14, 2018: Journal of Geriatric Oncology
Georgios Gaitanis, Ioannis D Bassukas
OBJECTIVE: To report the five-year follow up results of a prior prospective clinical trial (NCT01212562) on immunocryosurgery for the treatment of non-superficial basal cell carcinoma (BCC) ≤20 mm in diameter. MATERIALS AND METHODS: Immunocryosurgery consists of five weeks daily 5% imiquimod cream and a cryosurgery session on day fourteen. This combination cleared 95 ± 2% of BCCs at the eighteen month follow up. Herein, we present the results of the five year follow-up or per last available information of the aforementioned cohort...
September 12, 2018: Journal of Geriatric Oncology
Francisco J Tarazona-Santabalbina, Jorge Llabata-Broseta, Ángel Belenguer-Varea, David Álvarez-Martínez, David Cuesta-Peredo, Juan A Avellana-Zaragoza
OBJECTIVES: Comprehensive geriatric assessment (CGA) has shown to benefit older patients undergoing urological and orthopedic surgery. However, this approach has been scarcely assessed in patients elected for colorectal surgery. MATERIALS AND METHODS: Retrospective cohort of patients aged ≥70 years admitted for elective colorectal cancer surgery to a single hospital between 2008 and 2012. Upon admission, patients were assigned to a usual care (UC) plan or a CGA-based care (GS) plan conducted by a multidisciplinary team, according to standard clinical criteria...
September 11, 2018: Journal of Geriatric Oncology
Rosa Liperoti, Domenico Fusco, Maria C Cipriani, Maria R Lo Monaco, Graziano Onder
No abstract text is available yet for this article.
September 10, 2018: Journal of Geriatric Oncology
Sifra Bolle, Ellen M A Smets, Marije E Hamaker, Eugène F Loos, Julia C M van Weert
OBJECTIVES: Multidisciplinary team meetings aim to facilitate efficient and accurate communication surrounding the complex process of treatment decision making for older patients with cancer. This process is even more complicated for older (≥70 years) patients as the lack of empirical evidence on treatment regimens in patients with age-related problems such as comorbidity and polypharmacy, necessitates a patient-centred approach.This study investigates the decision making process for older patients with cancer during multidisciplinary team meetings and the extent to which geriatric evaluation and geriatric expertise contribute to this process...
September 10, 2018: Journal of Geriatric Oncology
Mackenzi Pergolotti, Michelle M Langer, Allison M Deal, Hyman B Muss, Kirsten Nyrop, Grant Williams
OBJECTIVES: The Mental Health Index (MHI) is widely used as a measure of mental health status, but has not been evaluated in the geriatric oncology population. This study evaluated the MHI-17 in a geriatric oncology population, to establish validity and scoring rules. MATERIALS AND METHODS: The Carolina Senior Registry (NCT01137825) was used to obtain data for 686 patients with cancer 65 and older who completed the MHI-17. The 17-item patient-reported measure produces one total score summing across four domains: anxiety, depression, positive affect, and sense of belonging...
September 8, 2018: Journal of Geriatric Oncology
Richard F Dunne, Breton Roussel, Eva Culakova, Chintan Pandya, Fergal J Fleming, Bradley Hensley, Allison M Magnuson, Kah Poh Loh, Maxence Gilles, Erika Ramsdale, Ronald J Maggiore, Aminah Jatoi, Karen M Mustian, William Dale, Supriya G Mohile
OBJECTIVES: Cancer cachexia, characterized by weight loss and sarcopenia, leads to a decline in physical function and is associated with poorer survival. Cancer cachexia remains poorly described in older adults with cancer. This study aims to characterize cancer cachexia in older adults by assessing its prevalence utilizing standard definitions and evaluating associations with components of the geriatric assessment (GA) and survival. MATERIALS AND METHODS: Patients with cancer older than 65 years of age who underwent a GA and had baseline CT imaging were eligible in this cross-sectional study...
September 5, 2018: Journal of Geriatric Oncology
Schroder Sattar, Shabbir M H Alibhai, Sandra L Spoelstra, Martine T E Puts
BACKGROUND: Falls are major health issues among older adults and even more so in those with cancer due to cancer and its treatment. Delays in cancer treatment caused by fall injuries may have significant implications on disease trajectory and patient outcomes. However, it is not known how falls impact cancer treatment in this population. METHODS: We conducted a convergent-parallel mixed-methods study at the Princess Margaret Cancer Centre in Toronto, Canada, to examine how falls impact cancer treatment in community-dwelling cancer patients aged ≥ 65, patients' fall reporting, and how falls were assessed and managed in oncology clinics...
August 30, 2018: Journal of Geriatric Oncology
Schroder Sattar, Sandra L Spoelstra, Shabbir M H Alibhai, Martine T E Puts
BACKGROUND: Falls are common among older adults and are of added concern among those with cancer due to cancer and its treatments. Knowledge on circumstances surrounding falls and fear of falling is vital for understanding how various factors may precipitate falls and for informing development of effective fall prevention interventions. The aim of the study was to explore circumstances of falls and fear of falling in community-dwelling older adults with cancer. METHOD: A convergent-parallel mixed-methods design was used in this cross-sectional study...
August 28, 2018: Journal of Geriatric Oncology
Krzysztof Bujko, Rob Glynne-Jones, Demetris Papamichael, Harm J T Rutten
In advising the optimal management for older patients, health care professionals try to balance the risks from frailty, vulnerability, and comorbidity against the patient's ultimate prognosis, potential functional outcomes and quality of life (QOL). At the same time it is important to involve the patient and incorporate their preferences. But how can we present and balance the potential downside of radical radiotherapy and risks of unsalvageable recurrence against the potential risks of postoperative morbidity and mortality associated with radical surgery? There are currently no nationally approved and evidence-based guidelines available to ensure consistency in discussions with older adults or frail and vulnerable patients...
August 24, 2018: Journal of Geriatric Oncology
Audrey Rambeau, Bérengère Beauplet, Heidi Laviec, Idlir Licaj, Alexandra Leconte, Claire Chatel, Priscille Le Bon, Julie Denhaerynck, Benedicte Clarisse, Nicole Frenkiel, Marie Lange, Florence Joly
INTRODUCTION: Among the various instruments recommended by the International Society of Geriatric Oncology, the Mini Mental State Examination (MMSE) is the most commonly used cognitive screening test before oncological treatment. Although the Montreal Cognitive Assessment (MoCA) has been shown to be more sensitive than the MMSE in several pathologies, no specific data exist for older patients with cancer. We aimed to compare the proportions of older patients with cancer who had screened positive for cognitive impairment according to the MMSE and MoCA scores obtained during a pretherapeutic geriatric assessment (GA) in oncology...
August 24, 2018: Journal of Geriatric Oncology
Jan J Jobsen, Judith G Middelburg, Job van der Palen, Sietske Riemersma, Ester Siemerink, Henk Struikmans, Sabine Siesling
BACKGROUND: The aim of this study was to analyze the distant metastases-free survival (DMFS), and disease-specific survival (DSS) after breast-conserving therapy (BCT) in older patients with breast cancer in a large, population-based, single-center cohort study with long-term follow-up. MATERIAL AND METHODS: Analyses were based on 1,425 women aged 65 years and older with breast cancer treated with BCT. Patients were divided in three age categories: 65 - 70 years, 71 - 75 years, and >75 years...
August 18, 2018: Journal of Geriatric Oncology
Tomohiro F Nishijima, Allison M Deal, Jennifer L Lund, Kirsten A Nyrop, Hyman B Muss, Hanna K Sanoff
BACKGROUND: Our aim was to evaluate the prognostic impact of three inflammatory markers - neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and lymphocyte monocyte ratio (LMR) - on overall survival (OS) in older adults with cancer. MATERIALS AND METHODS: Our sample includes 144 patients age ≥ 65 years with solid tumor cancer who completed a cancer-specific Geriatric Assessment (GA) from 2010 to 2014 and had pretreatment CBC with differential...
August 18, 2018: Journal of Geriatric Oncology
Maarten van Heinsbergen, Huub Maas, Stan Bessems, Jeroen Vogelaar, Paul Nijhuis, Liliane Keijzer-Bors, Angela van Liempd, Maryska Janssen-Heijnen
No abstract text is available yet for this article.
August 11, 2018: Journal of Geriatric Oncology
Cheng-Chieh Hsu, Ying-Tzu Huang, Yen-Han Tseng, Yung-Hung Luo, Yuh-Min Chen
No abstract text is available yet for this article.
August 10, 2018: Journal of Geriatric Oncology
Surbhi Kansal, Seema Rao
Developing countries like India are witnessing a demographic transition resulting in population ageing. This population expansion will in future increase the burden of diseases more prevalent in older patients. Since cancer incidence increases with age, a surge in geriatric patients with cancer will soon overburden the health care system of our country. In anticipation of this change, present retrospective study done at a tertiary care centre highlights the cancer spectrum in all age groups with emphasis on geriatric patients...
August 10, 2018: Journal of Geriatric Oncology
Susan L Green, David E Dawe, Zoann Nugent, Winson Y Cheung, Piotr M Czaykowski
OBJECTIVE: We aim to examine the use and outcomes of adjuvant chemotherapy in older patients with stage II and III colon cancer. MATERIAL AND METHODS: Using data from the SEER-Medicare database, we analyzed patients aged 66 or greater, diagnosed with stage II or III colon cancer between 1991 and 2007 who received surgery. Using Medicare claims, receipt of adjuvant chemotherapy was identified, and compared between age bands. Logistic regression modeling was performed to assess predictors of receipt of adjuvant chemotherapy, and Cox proportional hazards modeling was performed to assess predictors of mortality...
August 10, 2018: Journal of Geriatric Oncology
Joobin Sattar, Adi Kartolo, Wilma M Hopman, Joshua Matthew Lakoff, Tara Baetz
IMPORTANCE: Immunotherapy has emerged as an effective treatment option for the management of advanced cancers. The effects of these immune checkpoint inhibitors in the older patient population has not been adequately assessed. OBJECTIVE: To understand the impact of aging on CTLA-4 and PDL-1 inhibitors efficacy and immune-related adverse events (irAE) in the context of real-world management of advanced solid cancers. DESIGN, SETTING, AND PARTICIPANTS: This retrospective study involved all non-study patients with histologically-confirmed metastatic or inoperable solid cancers receiving immunotherapy at Kingston Health Sciences Centre...
August 10, 2018: Journal of Geriatric Oncology
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