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International Neurourology Journal

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https://www.readbyqxmd.com/read/29609425/lower-urinary-tract-symptoms-in-elderly-population-with-multiple-sclerosis
#1
Camille Chesnel, Audrey Charlanes, Claire Hentzen, Nicolas Turmel, Frédérique Le Breton, Samer Sheikh Ismael, Gérard Amarenco
PURPOSE: The aim of this study is to compare the clinical and urodynamic characteristics of urinary disorders in multiple sclerosis (MS) patients in a geriatric population with a nongeriatric population. METHODS: This study was conducted retrospectively between 2010 and 2016. Each patient with MS aged 65 and older was matched with 2 patients with MS aged less than 65 in sex, form of MS, and Expended Disability Status Scale (EDSS). Demographic data, urinary symptoms, treatment, quality of life, repercussion of lower urinary tract symptoms on daily life activities and psychological state and urodynamic parameters were collected...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29609424/synergistic-activities-of-abdominal-muscles-are-required-for-efficient-micturition-in-anesthetized-female-mice
#2
Chuan Zhang, Yingchun Zhang, Yolanda Cruz, Timothy B Boone, Alvaro Munoz
PURPOSE: To characterize the electromyographic activity of abdominal striated muscles during micturition in urethane-anesthetized female mice, and to quantitatively evaluate the contribution of abdominal responses to efficient voiding. METHODS: Cystometric and multichannel electromyographic recordings were integrated to enable a comprehensive evaluation during micturition in urethane-anesthetized female mice. Four major abdominal muscle domains were evaluated: the external oblique, internal oblique, and superior and inferior rectus abdominis...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29609423/intermittent-self-catheterization-in-older-adults-predictors-of-success-for-technique-learning
#3
Claire Hentzen, Rebecca Haddad, Samer Sheikh Ismael, Benoit Peyronnet, Xavier Gamé, Pierre Denys, Gilberte Robain, Gérard Amarenco
PURPOSE: The main goal of this retrospective study is to explore the predictors of success in learning clean intermittent self-catheterization (CISC) in patients over 65 years of age. The secondary goal is to assess whether in this population, the risk of failure to perform CISC is greater, compared with patients under 65 with similar pathologies. METHODS: All patients older than 65 consulting between January 2011 and January 2016 for learning CISC were included...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29609422/influence-of-the-short-term-intake-of-high-doses-of-solifenacin-and-trospium-on-cognitive-function-and-health-related-quality-of-life-in-older-women-with-urinary-incontinence
#4
Kirill Kosilov, Irina Kuzina, Sergay Loparev, Yuliya Gainullina, Liliya Kosilova, Alexandra Prokofyeva
PURPOSE: The aim of this study was to investigate the safety and the effects of elevated doses of solifenacin and trospium on cognitive function and health-related quality of life (HRQoL) in elderly women receiving treatment for urinary incontinence. METHODS: The study included 312 women aged 60-83 years (mean age, 69.4 years). All participants had scored at least 24 points on the Mini-Mental State Examination (MMSE) scale, and all of them had been diagnosed with urge urinary incontinence (UUI) or mixed urinary incontinence (MUI)...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29609421/clinical-efficacy-of-solifenacin-in-the-management-of-diabetes-mellitus-associated-versus-idiopathic-overactive-bladder-symptoms-a-multicenter-prospective-study
#5
Hoon Choi, Jae Hyun Bae, Cheol Young Oh, Seong Jin Jeong, Woo Jin Ko, Jong Bo Choi, Ju Tae Seo, Dong Hwan Lee, Joon Chul Kim, Kwang Woo Lee, Young Ho Kim
PURPOSE: To compare the clinical efficacy of anticholinergics for managing diabetes mellitus-associated overactive bladder (DM OAB) versus idiopathic overactive bladder (OAB) in Korean women. METHODS: We conducted a multicenter, prospective, parallel-group, open-label, 12-week study. Women (20-65 years old) with OAB symptoms for over 3 months were assigned to the DM OAB and idiopathic OAB groups. Changes in the Overactive Bladder Symptom Score (OABSS), urgency, urinary urgency incontinence, nocturia, daytime frequency according to a voiding diary, uroflowmetry, and postvoid residual urine volume (PVR) at the first visit (V1), week 4 (V2), and week 12 (V3) were compared...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29609420/efficacy-of-an-alpha-blocker-for-the-treatment-of-nonneurogenic-voiding-dysfunction-in-women-an-8-week-randomized-double-blind-placebo-controlled-trial
#6
Young-Suk Lee, Kyu-Sung Lee, Myung-Soo Choo, Joon Chul Kim, Jeong Gu Lee, Ju Tae Seo, Jeong Zoo Lee, Ji Youl Lee, Seung-June Oh, Yong Gil Na
PURPOSE: To evaluate the efficacy of an alpha-1 adrenergic receptor (α1-AR) blocker for the treatment of female voiding dysfunction (FVD) through a pressure-flow study. METHODS: This was a randomized, double-blind, placebo-controlled trial. Women aged ≥18 years with voiding symptoms, as defined by an American Urological Association symptom score (AUA-SS) ≥15 and a maximum flow rate (Qmax) <15 mL/sec with a voided volume of >100 mL and/or a postvoid residual (PVR) volume >150 mL, were randomly allocated to either the alfuzosin or placebo group...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29609419/add-on-therapy-with-the-%C3%AE-blockers-tamsulosin-and-naftopidil-improves-voiding-function-by-enhancing-neuronal-activity-in-prostatic-hyperplasia-rats
#7
Il-Gyu Ko, Lakkyong Hwang, Jun-Jang Jin, Sang-Hoon Kim, Jin Hee Han, Jung Won Jeon, Sung Tae Cho
PURPOSE: Benign prostatic hyperplasia (BPH) impacts quality of life in men by causing lower urinary tract symptoms. α1-Adrenoceptor (α1-AR) blockers improve lower urinary tract symptoms. We investigated the efficacy of add-on therapy with α1-AR blockers on BPH rats. METHODS: Rats in the drug-treated groups were orally administered each drug once a day for 30 days after orchiectomy. To induce BPH, rats were castrated and testosterone (20 mg/kg) was injected subcutaneously once per day for 30 days...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29609418/central-regulation-of-micturition-and-its-association-with-epilepsy
#8
REVIEW
Hyun-Jong Jang, Min Jung Kwon, Kyung-Ok Cho
Micturition is a complex process involving the bladder, spinal cord, and the brain. Highly sophisticated central neural program controls bladder function by utilizing multiple brain regions, including pons and suprapontine structures. Periaqueductal grey, insula, anterior cingulate cortex, and medial prefrontal cortex are components of suprapontine micturition centers. Under pathologic conditions such as epilepsy, urinary dysfunction is a frequent symptom and it seems to be associated with increased suprapontine cortical activity...
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29609417/response-to-current-pharmacologic-approaches-in-painful-bladder-research-an-update
#9
Jayoung Kim
No abstract text is available yet for this article.
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29609416/importance-of-central-regulation-for-lower-urinary-tract-functions
#10
Young Sam Cho
No abstract text is available yet for this article.
March 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29385788/animal-modelling-of-interstitial-cystitis-bladder-pain-syndrome
#11
REVIEW
Lori Birder, Karl-Erik Andersson
The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains elusive and may involve multiple causes. To better understand its pathophysiology, many efforts have been made to create IC/BPS models. Most existing models of IC/BPS strive to recreate bladder-related features by applying noxious intravesical or systemic stimuli to healthy animals. These models are useful to help understand various mechanisms; however, they are limited to demonstrating how the bladder and nervous system respond to noxious stimuli, and are not representative of the complex interactions and pathophysiology of IC/BPS...
January 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29385787/differences-in-urodynamic-parameters-according-to-the-presence-of-a-hunner-lesion-in-women-with-interstitial-cystitis-bladder-pain-syndrome
#12
Sun Tae Ahn, Hyeong Guk Jeong, Tae Yong Park, Jong Wook Kim, Hong Seok Park, Du Geon Moon, Jeong Gu Lee, Mi Mi Oh
PURPOSE: Differences in the severity of subjective symptoms have been noted depending on whether a Hunner lesion is present in women with interstitial cystitis/bladder pain syndrome (IC/BPS). In this study, we aimed to identify differences in objective urodynamic parameters in women with IC/BPS according to the presence of a Hunner lesion. METHODS: This cross-sectional study included a total of 55 patients with IC/BPS. IC/BPS and the presence of a Hunner lesion on cystoscopy were diagnosed according to American Urological Association guidelines...
January 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29385786/expression-of-glial-cell-line-derived-neurotrophic-factor-gdnf-and-the-gdnf-family-receptor-alpha-subunit-1-in-the-paravaginal-ganglia-of-nulliparous-and-primiparous-rabbits
#13
Verónica García-Villamar, Laura G Hernández-Aragón, Jesús R Chávez-Ríos, Arturo Ortega, Margarita Martínez-Gómez, Francisco Castelán
PURPOSE: To evaluate the expression of glial cell line-derived neurotrophic factor (GDNF) and its receptor, GDNF family receptor alpha subunit 1 (GFRα-1) in the pelvic (middle third) vagina and, particularly, in the paravaginal ganglia of nulliparous and primiparous rabbits. METHODS: Chinchilla-breed female rabbits were used. Primiparas were killed on postpartum day 3 and nulliparas upon reaching a similar age. The vaginal tracts were processed for histological analyses or frozen for Western blot assays...
January 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29385785/urothelial-dysfunction-and-chronic-inflammation-are-associated-with-increased-bladder-sensation-in-patients-with-chronic-renal-insufficiency
#14
Sheng-Fu Cheng, Yuan-Hong Jiang, Hann-Chorng Kuo
PURPOSE: Chronic kidney disease (CKD) or end-stage renal disease (ESRD) patients usually have lower urinary tract symptoms, such as frequency and urgency. Additionally, they frequently suffer from urinary tract infections. This study investigated dysfunction and chronic inflammation of the bladder urothelium in ESRD/CKD patients. METHODS: This study enrolled 27 patients with CKD (n=13) or ESRD (n=14) for urodynamic studies and bladder biopsies. Patients presented with detrusor underactivity (DU; n=8) or bladder oversensitivity (BO; n=19)...
January 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29385784/laparoscopic-approach-for-intravesical-surgery-using-pneumovesicum-in-urology-literature-review
#15
REVIEW
Bum Sik Tae, Hoon Choi, Jae Young Park, Jae Hyun Bae
Minimally invasive laparoscopic surgical procedures are increasingly being used in the management of various urological diseases. In particular, the laparoscopic approach for intravesical surgery using pneumovesicum (LPV) is a minimally invasive alternative with potential advantages including decreased morbidity, shorter hospital stays, and improved cosmesis. We review the applications of LPV in urology, summarize data for different surgical approaches, and provide an overview of patient management, as well as other considerations...
January 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29385783/the-therapeutic-effect-of-human-embryonic-stem-cell-derived-multipotent-mesenchymal-stem-cells-on-chemical-induced-cystitis-in-rats
#16
Sang Wook Lee, Chae-Min Ryu, Jung-Hyun Shin, Daeheon Choi, Aram Kim, Hwan Yeul Yu, Ju-Young Han, Hye-Yeon Lee, Jisun Lim, Yong Hwan Kim, Jinbeom Heo, Seungun Lee, Hyein Ju, Sujin Kim, Ki-Sung Hong, Ji-Yeon Han, Miho Song, Hyung-Min Chung, Jun Ki Kim, Dong-Myung Shin, Myung-Soo Choo
PURPOSE: To evaluate the therapeutic effect of human embryonic stem cell (hESC)-derived multipotent mesenchymal stem cells (M-MSCs) on ketamine-induced cystitis (KC) in rats. METHODS: To induce KC, 10-week-old female rats were injected with 25-mg/kg ketamine hydrochloride twice weekly for 12 weeks. In the sham group, phosphate buffered saline (PBS) was injected instead of ketamine. One week after the final injection of ketamine, the indicated doses (0.25, 0.5, and 1×106 cells) of M-MSCs (KC+M-MSC group) or PBS vehicle (KC group) were directly injected into the bladder wall...
January 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29385782/animal-model-of-interstitial-cystitis-bladder-pain-syndrome
#17
Whi-An Kwon
No abstract text is available yet for this article.
January 2018: International Neurourology Journal
https://www.readbyqxmd.com/read/29298475/neuropelveology-an-emerging-discipline-for-the-management-of-chronic-pelvic-pain
#18
REVIEW
Marc Possover, Karl-Erik Andersson, Axel Forman
Chronic pelvic pain (CPP) is a common condition involving multiple, organ-specific medical specialties, each with its own approach to diagnosis and treatment. Management requires knowledge of the interplay between pelvic organ function and neuro-functional anatomy, and of the neurologic and psychological aspects of CPP, but no current specialty fully encompasses this approach. Neuropelveology is an emerging discipline focusing on pathologies of the pelvic nervous system on a cross-disciplinary basis. It involves a neurological/neurosurgical approach, combining the knowledge required for a proper neurologic diagnosis, confirmation by transvaginal/transrectal examination of the pelvic nerves, and advanced laparoscopic surgery in selected cases of CPP...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29298474/current-pharmacologic-approaches-in-painful-bladder-research-an-update
#19
REVIEW
Karl-Erik Andersson, Lori Birder
The symptoms of interstitial cystitis (IC)/bladder pain syndrome (BPS) may have multiple causes and involve many contributing factors. Traditional treatments (intravesical instillations) have had a primary focus on the bladder as origin of symptoms without adequately considering the potential influence of other local (pelvic) or systemic factors. Systemic pharmacological treatments have had modest success. A contributing factor to the low efficacy is the lack of phenotyping the patients. Individualized treatment based on is desirable, but further phenotype categorization is needed...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29298473/urinary-incontinence-85-an-expanded-prostate-cancer-composite-epic-score-cutoff-value-for-urinary-incontinence-determined-using-long-term-functional-data-by-repeated-prospective-epic-score-self-assessment-after-radical-prostatectomy
#20
Karolin Bossert, Venkat M Ramakrishnan, Burkhardt Seifert, Kurt Lehmann, Lukas J Hefermehl
PURPOSE: To determine an objective cutoff value (COV) for urinary incontinence (UI) using the Expanded Prostate Cancer Composite (EPIC) score after radical prostatectomy (RP). METHODS: From 2004-2013, all RP patients at our institution completed the EPIC urinary domain (EPIC-UD) questionnaire preoperatively and 6 weeks; 3, 6, 9, 12, and 18 months postoperatively; and yearly thereafter. The EPIC-UD is composed of several questions, 4 of which address UI qualitatively (EPIC-UI)...
December 2017: International Neurourology Journal
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