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International Neurourology Journal

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https://www.readbyqxmd.com/read/27915481/effects-of-combination-treatment-of-alpha-1-adrenergic-receptor-antagonists-on-voiding-dysfunction-study-on-target-organs-in-overactive-bladder-rats
#1
Il Gyu Ko, Bo Min Moon, Sung Eun Kim, Jun Jang Jin, Lakkyong Hwang, Eun Sang Ji, Chang Ju Kim, Tai Hyung Kim, Hyun Hee Choi, Kyung Jin Chung
PURPOSE: Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The α1-AR antagonists constitute a variety of drugs according to the receptor subtype affinity. This study investigated the efficacy of tamsulosin, naftopidil, and a combination of the two on OAB rats. METHODS: The OAB rat model was induced by an intraperitoneal injection of cyclophosphamide for 14 days...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915480/genetic-and-epigenetic-alterations-in-bladder-cancer
#2
REVIEW
Hong-Tao Li, Christopher E Duymich, Daniel J Weisenberger, Gangning Liang
Bladder cancer is one of the most common cancers worldwide, with a high rate of recurrence and poor outcomes as a result of relapse. Bladder cancer patients require lifelong invasive monitoring and treatment, making bladder cancer one of the most expensive malignancies. Lines of evidence increasingly point to distinct genetic and epigenetic alteration patterns in bladder cancer, even between the different stages and grades of disease. In addition, genetic and epigenetic alterations have been demonstrated to play important roles during bladder tumorigenesis...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915479/trends-in-next-generation-sequencing-and-a-new-era-for-whole-genome-sequencing
#3
REVIEW
Sang Tae Park, Jayoung Kim
This article is a mini-review that provides a general overview for next-generation sequencing (NGS) and introduces one of the most popular NGS applications, whole genome sequencing (WGS), developed from the expansion of human genomics. NGS technology has brought massively high throughput sequencing data to bear on research questions, enabling a new era of genomic research. Development of bioinformatic software for NGS has provided more opportunities for researchers to use various applications in genomic fields...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915478/targeting-the-phosphatidylinositol-3-kinase-pathway-in-gastric-cancer-can-omics-improve-outcomes
#4
REVIEW
Phu Tran, Cham Nguyen, Samuel J Klempner
Phosphatidylinositol-3-kinase (PI3K) pathway signaling is an established oncogenic signal transduction pathway implicated in multiple malignancies. Therapeutic targeting of PI3K pathway components has improved outcomes in chronic lymphocytic leukemia, kidney cancer, breast cancer, and neuroendocrine tumors. Gastric cancers harbor some of the highest rates of oncogenic alterations in PI3K but attempts to translate this genomic observation have met with limited clinical success and novel approaches are needed...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915477/treadmill-exercise-improves-memory-function-depending-on-circadian-rhythm-changes-in-mice
#5
Dong Sup Hwang, Hyo Bum Kwak, Il Gyu Ko, Sung Eun Kim, Jun Jang Jin, Eun Sang Ji, Hyun Hee Choi, Oh Young Kwon
PURPOSE: Exercise enhances memory function by increasing neurogenesis in the hippocampus, and circadian rhythms modulate synaptic plasticity in the hippocampus. The circadian rhythm-dependent effects of treadmill exercise on memory function in relation with neurogenesis were investigated using mice. METHODS: The step-down avoidance test was used to evaluate short-term memory, the 8-arm maze test was used to test spatial learning ability, and 5-bromo-2'-deoxyuridine immunofluorescence was used to assess neurogenesis...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915476/translational-research-for-pediatric-lower-urinary-tract-dysfunction
#6
REVIEW
Akihiro Kanematsu
This review provides a comprehensive view of translational research aimed at elucidating the pathophysiology of pediatric lower urinary tract dysfunction (LUTD). A web search was conducted according to combinations of keywords, and the significance of each article was defined by the author. The dramatic evolution of the mass analysis method of genomes, transcripts, and proteins has enabled a comprehensive analysis of molecular events underlying diseases, and these methodologies have also been applied to pediatric LUTD...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915475/how-precisely-can-prostate-cancer-be-managed
#7
REVIEW
Liyan Zhuang, Matthew T Johnson
Progress has been made in applying genetic information to disease management in the postgenomic era, and precision medicine is emerging in prostate cancer management. The prostate health index, the 4-kallikrein (4K) score, and the PCA3, TMPRSS2- ERG, and Prostarix tests have potential for refining prostate cancer screening in conjunction with traditional prostate-specific antigen testing. The Confirm MDx and PCA3 tests have shown promise in identifying men who need be rebiopsied after a primary negative biopsy...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915474/racial-differences-in-the-diagnosis-and-treatment-of-prostate-cancer
#8
REVIEW
Giuliano Di Pietro, Ganna Chornokur, Nagi B Kumar, Chemar Davis, Jong Y Park
Disparities between African American and Caucasian men in prostate cancer (PCa) diagnosis and treatment in the United States have been well established, with significant racial disparities documented at all stages of PCa management, from differences in the type of treatment offered to progression-free survival or death. These disparities appear to be complex in nature, involving biological determinants as well as socioeconomic and cultural aspects. We present a review of the literature on racial disparities in the diagnosis of PCa, treatment, survival, and genetic susceptibility...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915473/urine-proteomics-in-the-era-of-mass-spectrometry
#9
REVIEW
Ashley Beasley-Green
With the technological advances of mass spectrometry (MS)-based platforms, clinical proteomics is one of the most rapidly growing areas in biomedical research. Urine proteomics has become a popular subdiscipline of clinical proteomics because it is an ideal source for the discovery of noninvasive disease biomarkers. The urine proteome offers a comprehensive view of the local and systemic physiology since the proteome is primarily composed of proteins/peptides from the kidneys and plasma. The emergence of MS-based proteomic platforms as prominent bioanalytical tools in clinical applications has enhanced the identification of protein-based urinary biomarkers...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915472/pathomechanism-of-interstitial-cystitis-bladder-pain-syndrome-and-mapping-the-heterogeneity-of-disease
#10
REVIEW
Jia-Fong Jhang, Hann-Chorng Kuo
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a heterogeneous syndrome which is usually characterized by urinary frequency, nocturia, and bladder pain. Several pathomechanisms have been proposed, including uroepithelial dysfunction, mast cell activation, neurogenic inflammation, autoimmunity, and occult urinary tract infections. It is possible that an inflammatory process alters regulation of urothelial homeostasis and results in dysfunction of the bladder epithelium. Different phenotypes of IC/BPS have been explored including Hunner and non-Hunner type IC, hypersensitive bladder, and bladder pain both with and without functional somatic syndrome...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915471/new-attempts-to-overcome-the-urinary-tract-disorders
#11
Khae Hawn Kim
No abstract text is available yet for this article.
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915470/are-we-ready-to-use-the-omics-strategies-for-precision-medicine
#12
Jayoung Kim
No abstract text is available yet for this article.
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27706018/controls-of-nuclear-factor-kappa-b-signaling-activity-by-5-amp-activated-protein-kinase-activation-with-examples-in-human-bladder-cancer-cells
#13
Bo-Hwa Choi, Da-Hyun Lee, Jin Kim, Ju-Hee Kang, Chang-Shin Park
Generally, both lipopolysaccharide (LPS)- and hypoxia-induced nuclear factor kappa B (NF-κB) effects are alleviated through differential posttranslational modification of NF-κB phosphorylation after pretreatment with 5´-AMP-activated protein kinase (AMPK) activators such as 5´-aminoimidazole-4-carboxamide ribonucleotide (AICAR) or the hypoglycemic agent metformin. We found that AICAR or metformin acts as a regulator of LPS/NF-κB-or hypoxia/NF-κB-mediated cyclooxygenase induction by an AMPK-dependent mechanism with interactions between p65-NF-κB phosphorylation and acetylation, including in a human bladder cancer cell line (T24)...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27706017/application-of-virtual-augmented-and-mixed-reality-to-urology
#14
Alaric Hamacher, Su Jin Kim, Sung Tae Cho, Sunil Pardeshi, Seung Hyun Lee, Sung-Jong Eun, Taeg Keun Whangbo
Recent developments in virtual, augmented, and mixed reality have introduced a considerable number of new devices into the consumer market. This momentum is also affecting the medical and health care sector. Although many of the theoretical and practical foundations of virtual reality (VR) were already researched and experienced in the 1980s, the vastly improved features of displays, sensors, interactivity, and computing power currently available in devices offer a new field of applications to the medical sector and also to urology in particular...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27706016/abnormal-sensory-protein-expression-and-urothelial-dysfunction-in-ketamine-related-cystitis-in-humans
#15
Yao Chou Tsai, Lori Birder, Hann-Chorng Kuo
PURPOSE: The aim of this study was to analyze patterns of sensory protein expression and urothelial dysfunction in ketamine-related cystitis (KC) in humans. METHODS: Biopsies of bladder mucosa were performed in 29 KC patients during cystoscopy. Then specimens were analyzed for tryptase, zonula occludens-1 (ZO-1), E-cadherin, and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) with immunofluorescence staining and quantification. In addition, 10 healthy control bladder specimens were analyzed and compared with the KC specimens...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27706015/translation-and-linguistic-validation-of-the-korean-version-of-the-benefit-satisfaction-and-willingness-to-continue-questionnaire-for-patients-with-overactive-bladder
#16
Sung Yong Cho, Hahn-Ey Lee, Seong Jin Jeong, Seung-June Oh
PURPOSE: The goal of this study was to develop a Korean version of the Benefit, Satisfaction, and Willingness to Continue (BSW) questionnaire from the original version, with subsequent linguistic validation by Korean patients with overactive bladder who undergo active treatment by a physician. METHODS: Translation and linguistic validation were performed in January 2013. The validation process included permission for translation, forward translation, reconciliation, backward translation, cognitive debriefing, and proofreading...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27706014/typical-value-ranges-and-typical-signal-patterns-in-the-initial-cough-in-patients-with-neurogenic-bladder-quality-control-in-urodynamic-studies
#17
Tianji Lu, Limin Liao
PURPOSE: The goal of this study was to establish typical value ranges (TVRs) and to analyze typical signal patterns (TSPs) of the initial cough (cough before bladder filling) for quality control in urodynamic studies. METHODS: A total of 539 urodynamic traces from patients with neurogenic bladder obtained over the course of a year were retrospectively reviewed. The TVRs for cough amplitude in measurements of the intravesical pressure (Pves), abdominal pressure (Pabd), and detrusor pressure (Pdet) during the initial cough were established...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27706013/the-early-histological-effects-of-intravesical-instillation-of-platelet-rich-plasma-in-cystitis-models
#18
M İrfan Dönmez, Kubilay İnci, Naciye Dilara Zeybek, H Serkan Doğan, Ali Ergen
PURPOSE: To evaluate the early histological effects of the intravesical instillation of platelet-rich plasma (PRP) in rabbit models of interstitial and hemorrhagic cystitis. METHODS: Thirty-six rabbits were classified into 6 groups: saline (S), S+PRP, hydrochloric acid (HCl), HCl+PRP, cyclophosphamide (CyP), and CyP+PRP. At 48 hours after induction, PRP was prepared and intravesically administered to the S+PRP, HCl+PRP, and CyP+PRP groups. Bladder sections were stained with toluidine blue for mast cell counting and with hematoxylin and eosin for histopathology and mitotic index determination...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27706012/sacral-neuromodulation-in-patients-with-a-cardiac-pacemaker
#19
Abdullah A Gahzi, Dean S Elterman, Magdy Hassouna
The objective of this study was to describe our experience using sacral neuromodulation to treat urinary urgency, frequency, urge incontinence, and chronic urinary retention in patients with cardiac pacemakers. With the increasingly widespread use of InterStim for bladder function restoration, we are seeing more complex patients with multiple comorbidities, including cardiac conditions. Herein, we report 3 cases of individuals with cardiac pacemakers who underwent InterStim implantation to treat urinary conditions...
September 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27706011/diagnostic-tool-for-assessing-overactive-bladder-symptoms-could-the-international-prostate-symptom-storage-subscore-replace-the-overactive-bladder-symptom-score
#20
Ji Sung Shim, Jae Heon Kim, Hoon Choi, Jae Young Park, Jae Hyun Bae
PURPOSE: The goal of this study was to compare the International Prostate Symptom Storage Subscore (IPSS-s) and the overactive bladder symptom score (OABSS) as tools for assessing the symptoms of overactive bladder (OAB). METHODS: A cross-sectional study was conducted of a sample of 1,341 patients aged 50 years and older with lower urinary tract complaints who had undergone a medical examination at one of several centers. For each patient, we reviewed the International Prostate Symptom Score and the OABSS...
September 2016: International Neurourology Journal
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