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International Neurourology Journal

Jung-Wan Cho, Sun-Young Jung, Dae-Young Kim, Yong-Rak Chung, Hyun-Hee Choi, Jung-Won Jeon, Jin-Hee Han
PURPOSE: Maternal lipopolysaccharide (LPS) injection induces neurodevelopmental disorders, such as cerebral palsy. Exercise activates phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway that enhances neurogenesis. Wnt ligands are also implicated in the hippocampal neurogenesis and synaptic plasticity. Glycogen synthase kinase-3β (GSK-3β) is a downstream molecule of Akt, and GSK-3β is known to modulate hippocampal neurogenesis negatively. METHODS: Cerebral palsy was made by maternal LPS-injection...
October 2018: International Neurourology Journal
Jae-Min Lee, Tae-Woon Kim, Sang-Seo Park, Jin-Hee Han, Mal-Soon Shin, Baek-Vin Lim, Sang-Hoon Kim, Seung-Soo Baek, Young Sam Cho, Khae Hawn Kim
PURPOSE: Rotenone is the most widely used neurotoxin for the making Parkinson disease (PD) animal model. The neurodegenerative disorder PD shows symptoms, such as slowness of movements, tremor at resting, rigidity, disturbance of gait, and instability of posture. We investigated whether treadmill running improves motor ability using rotenone-caused PD rats. The effect of treadmill running on PD was also assessed in relation with apoptosis of cerebellar Purkinje cells. METHODS: Treadmill running was applied to the rats in the exercise groups for 30 minutes once a day for 4 weeks, starting 4 weeks after birth...
October 2018: International Neurourology Journal
Eun-Jin Moon, Il-Gyu Ko, Sung-Eun Kim, Jun-Jang Jin, Lakkyong Hwang, Chang-Ju Kim, Hyeonjun An, Bong-Jae Lee, Jae-Woo Yi
PURPOSE: Sleep deprivation induces depressive symptoms. Dexmedetomidine is a α2-adrenoreceptor agonist and this drug possesses sedative, anxiolytic, analgesic, and anesthetic-sparing effect. In this study, the action of dexmedetomidine on sleep deprivation-induced depressive behaviors was investigated using mice. METHODS: For the inducing of sleep deprivation, the mice were placed inside a water cage containing 15 platforms and filled with water up to 1 cm below the platform surface for 7 days...
October 2018: International Neurourology Journal
Hyosun Lim, Sun Hwa Park, Sung Won Kim, Kyung-Ok Cho
PURPOSE: Mesenchymal stem cells (MSCs) have demonstrated great promises for the treatment of ischemic stroke. Previously, we identified a new source of MSCs located in the inferior turbinate. We investigated therapeutic potentials of human turbinate- derived mesenchymal stem cells (hTMSCs) in ischemic stroke. METHODS: Ischemic stroke was induced by the intraluminal occlusion of middle cerebral artery (MCAo) for 50 minutes in rats. At one day after MCAo, hTMSCs, adipose tissue-derived MSCs (AdMSCs), or phosphate buffered saline (PBS) were transplanted into the striatum...
October 2018: International Neurourology Journal
Chang Hoon Cho, Zhongxi Yang, Ki Hyun Yoo, Alfredo Oliveros, Mi Hyeon Jang
PURPOSE: Although aging causes functional declines in cognition, the molecular mechanism underlying these declines remains largely unknown. Recently, the spindle checkpoint kinase budding uninhibited by benzimidazole-related 1 (BubR1) has emerged as a key determinant for age-related pathology in various tissues including brain. However, the neurobehavioral impact of BubR1 has not been explored. In this study, we investigated the role of BubR1 in behavioral function. METHODS: To investigate the neurobiological functions of BubR1 in vivo, we utilized transgenic mice harboring BubR1 hypomorphic alleles (BubR1H/H mice), which produce low amounts of BubR1 protein, as well as mice that have specific knockdown of BubR1 in the adult dentate gyrus...
October 2018: International Neurourology Journal
Wongyoung Lee, Soulmee Koh, Soondo Hwang, Sung Hyun Kim
Parkinson disease (PD) is the second most prevalent neurodegenerative disorder after Alzheimer disease. The loss of specific brain area, the substantia nigra pars compacta is known as a major etiology, however it is not fully understood how this neurodegeneration is initiated and what precisely causes this disease. As one aspect of pathophysiology for PD, synaptic dysfunction (synaptopathy) is thought to be an earlier appearance for neurodegeneration. In addition, some of the familial factors cumulatively exhibit that these factors such as α-synuclein, leucine-rich repeat kinase 2, parkin, PTEN-induced kinase 1, and DJ-1 are involved in the regulation of synaptic function and missense mutants of familial factors found in PD-patient show dysregulation of synaptic functions...
October 2018: International Neurourology Journal
Syed M Q Hussaini, Mi Hyeon Jang
Previously believed to solely play a supportive role in the central nervous system, astrocytes are now considered active players in normal brain function. Evidence in recent decades extends their contributions beyond the classically held brain glue role; it's now known that astrocytes act as a unique excitable component with functions extending into local network modulation, synaptic plasticity, and memory formation, and postinjury repair. In this review article, we highlight our growing understanding of astrocyte function and physiology, the increasing role of gliotransmitters in neuron-glia communication, and the role of astrocytes in modulating synaptic plasticity and cognitive function...
October 2018: International Neurourology Journal
Jin Wook Kim
No abstract text is available yet for this article.
October 2018: International Neurourology Journal
Chang-Ju Kim
No abstract text is available yet for this article.
October 2018: International Neurourology Journal
Rebekah J Park, Yeo Jin Hong, Yifan Wu, Paul Myungchul Kim, Young-Kwon Hong
No abstract text is available yet for this article.
September 2018: International Neurourology Journal
Jeongok Park, Eun Sook Kim, Young Joo Lee, Hyo Serk Lee, Ju Tae Seo
PURPOSE: Urinary incontinence (UI) is associated with nursing home admission, functional decline, and risk of death among community-dwelling older adults. Little information, however, is available on sex differences in lower urinary tract symptoms (LUTS) in older Korean adults exclusively living in rural areas. This study examined sex-related differences in LUTS, factors associated with UI in older adults living in rural areas, and health-related quality of life (HRQoL) in incontinent older adults...
September 2018: International Neurourology Journal
Kristian D Stensland, Bennett Sluis, Jay Vance, Jared P Schober, Lara S MacLachlan, Arthur P Mourtzinos
PURPOSE: To identify factors associated with successful sacral nerve stimulator (SNS) trial after SNS implantation for the treatment of medication refractory overactive bladder (OAB). METHODS: Patients undergoing treatment for OAB at Lahey Hospital and Medical Center between 2004 and 2016 were identified. Patients undergoing SNS placement were identified; SNS success was defined as permanent implantation of the SNS. Demographic, clinical and treatment data were extracted from patient charts; uni- and multivariate analyses were conducted to identify factors associated with SNS treatment success...
September 2018: International Neurourology Journal
Kang Jun Cho, Jun Sung Koh, Jin Bong Choi, Joon Chul Kim
PURPOSE: To investigate factors associated with early recovery of stress urinary incontinence (SUI) following holmium laser enucleation of the prostate (HoLEP) in patients with benign prostatic enlargement (BPE). METHODS: The medical records of 393 patients who underwent HoLEP for BPE were retrospectively reviewed. Patients with SUI following HoLEP were selected and divided into 2 groups: those who experienced early recovery of SUI and those who experienced persistent SUI...
September 2018: International Neurourology Journal
Ok-Hee Cho, Yang-Sook Yoo, Joon Chul Kim, Ran Hee Park, Kyung-Hye Hwang
PURPOSE: This study aimed to investigate the severity of lower urinary tract symptoms (LUTS) and to identify factors that influenced LUTS in advanced cancer patients with chemotherapy-induced peripheral neuropathy (CIPN). METHODS: This cross-sectional study included a total of 158 advanced cancer patients with CIPN. A structured questionnaire including the International Prostate Symptom Score and the Functional Assessment of Cancer Therapy/Gynecology Oncology Group/Neurotoxicity scale was used...
September 2018: International Neurourology Journal
Arnaud Declemy, Camille Chesnel, Audrey Charlanes, Frederique Le Breton, Samer Sheikh Ismael, Gerard Amarenco
PURPOSE: The aim of this study was to describe lower urinary tract symptoms in neuromyelitis optica (NMO), and to compare these data with urinary disorders observed in multiple sclerosis (MS) patients. METHODS: Retrospective study of data collected from January 1997 to July 2017 using the database from a Neuro-Urology Department of a university hospital. NMO and MS patients were matched for sex, age, and Expanded Disability Status Scale (EDSS). RESULTS: Twenty-six patients with NMO were included and compared with 33 MS patients...
September 2018: International Neurourology Journal
Paulo César Rodrigues Palma, Marilene Vale de Castro Monteiro, Marta Alicia Ledesma, Sebastián Altuna, Juan José Luis Sardi, Cássio Luís Zanettini Riccetto
PURPOSE: To evaluate the safety and efficacy of a surgical polypropylene mesh for correction of anterior vaginal prolapse, with or without apical defects, by providing simultaneous reinforcement at the anterior and apical aspects of the vagina with a single-incision approach. METHODS: This was a prospective, multicenter, single-arm study involving women with baseline stage ≥2 anterior and/or apical vaginal wall prolapse according to the Pelvic Organ Prolapse Quantification (POP-Q) system...
September 2018: International Neurourology Journal
Jee Soo Park, Hae Do Jung, Young Sam Cho, Mei Hua Jin, Chang Hee Hong
PURPOSE: To evaluate whether mild chemical irritation of the bladder in neonatal rats is associated with persistent vanilloid receptor transient receptor potential vanilloid subfamily 1 (TRPV1) activity in adult rats. METHODS: Female Sprague-Dawley rats were used. Ten-day-old rat pups underwent bladder sensitization via intravesical infusion of 0.2% acetic acid in saline with or without prior bladder desensitization with capsaicin. After 8 weeks, 3 groups of rats (control [group 1], bladder sensitization [group 2], and bladder desensitization [group 3]) underwent cystometry...
September 2018: International Neurourology Journal
María de Los Ángeles Carrasco-Ruiz, Laura G Hernández-Aragón, Jesús Ramsés Chávez-Ríos, Jorge Rodríguez-Antolín, Pablo Pacheco, Margarita Martínez-Gómez, Estela Cuevas-Romero, Francisco Castelán
PURPOSE: To characterize the relationship between serum estradiol levels and the expression of glucose transporter type 4 (Glut4) in the pubococcygeus and iliococcygeus muscles in female rats. METHODS: The muscles were excised from virgin rats during the metestrus and proestrus stages of the estrous cycle, and from sham and ovariectomized rats implanted with empty or estradiol benzoate-filled capsules. The expression of estrogen receptors (ERs) was inspected in the muscles at metestrus and proestrus...
September 2018: International Neurourology Journal
Alaric Hamacher, Taeg Keun Whangbo, Su Jin Kim, Kyung Jin Chung
In urology technologies and surgical practices are constantly evolving and virtual reality (VR) simulation has become a significant supplement to existing urology methods in the training curricula of urologists. However, new developments in urology also require training and simulation for a wider application. In order to achieve this VR and simulation could play a central role. The purpose of this article is a review of the principal applications for VR and simulation in the field of urology education and to demonstrate the potential for the propagation of new progressive treatments...
September 2018: International Neurourology Journal
Su Jin Kim
No abstract text is available yet for this article.
September 2018: International Neurourology Journal
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