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Asian Pacific Journal of Tropical Medicine

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https://www.readbyqxmd.com/read/28107874/correlation-of-runx3-expression-with-microvessel-density-in-colorectal-adenocarcinoma-tissues-and-clinical-significance
#1
Jun Xue, Xue-Liang Wu, Xian-Tao Huang, Ming Qu, Fei Guo, Guang-Yuan Sun, Peng-Cheng Zhang, Lei Han, Li-Ming Pan
OBJECTIVE: To study the expression of RUNX3 in colorectal adenocarcinoma tissues and its correlation with microvessel density (MVD), and investigate the clinical pathological prognostic significance of RUNX3 and MVD in patients with colorectal cancer. METHODS: The expression value of RUNX3 and MVD in 70 specimens' colorectal adenocarcinoma tissues were detected by immunohistochemistry staining technique. The correlation between their expression and the clinicopathologic features was also investigated...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107873/situation-analysis-of-cutaneous-leishmaniasis-in-an-endemic-area-south-of-iran
#2
Mansour Nazari, Saman Nazari, Ahmad Ali Hanafi-Bojd, Ali Najafi, Sasan Nazari
OBJECTIVE: To update current situation of the cutaneous leishmaniasis (CL) in Kazerun County, southwest of Iran and to analyse the epidemiological aspects of the disease during 2005-2015. METHODS: Data on CL were obtained from the Health Center of Kazerun County, and then were analysed and mapped using SPSS and Arc GIS 10.3. RESULTS: A total of 700 cases of CL were recorded during the study period with an overall decreasing trend from 2005 to 2015...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107872/mir-21-targets-and-inhibits-tumor-suppressor-gene-pten-to-promote-prostate-cancer-cell-proliferation-and-invasion-an-experimental-study
#3
Yu Yang, Jia-Xiang Guo, Zhi-Qiang Shao
OBJECTIVE: To study whether miR-21 targets and inhibits tumor suppressor gene PTEN can promote prostate cancer cell proliferation and invasion. METHODS: Prostate cancer cell lines PC-3 were cultured and divided into negative control group (NC group), miR-21 group, pcDNA3.1 group, miR-21+pcDNA3.1 group and miR-21+PTEN group that were transfected with different miR and plasmid, respectively. After 12 h and 24 h of transfection, the cell viability and invasive cell number were determined; after 24 h of transfection, Bcl-2, Survivin, MMP2, MMP9, PTEN, PI3K, and AKT expression in cells were determined...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107871/forecasting-the-number-of-zoonotic-cutaneous-leishmaniasis-cases-in-south-of-fars-province-iran-using-seasonal-arima-time-series-method
#4
Mehdi Sharafi, Haleh Ghaem, Hamid Reza Tabatabaee, Hossein Faramarzi
OBJECTIVE: To predict the trend of cutaneous leishmaniasis and assess the relationship between the disease trend and weather variables in south of Fars province using Seasonal Autoregressive Integrated Moving Average (SARIMA) model. METHODS: The trend of cutaneous leishmaniasis was predicted using Mini tab software and SARIMA model. Besides, information about the disease and weather conditions was collected monthly based on time series design during January 2010 to March 2016...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107870/identifications-of-drug-resistance-mutations-among-antiretroviral-treatment-naive-hiv-1-patients-in-peninsular-malaysia
#5
Rozainanee Mohd Zain, Nabila Ibrahim, Suriani Ismail, Jeyanthi Suppiah, Nor Aziyah Mat Rahim, Ravindran Thayan
OBJECTIVE: To determine drug resistance mutations and the HIV-1 subtypes among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia. METHODS: A total of 45 samples from four hospitals that provide HIV viral load services were subjected to the amplification of the protease and two third of reverse transcriptase regions of the pol gene by RT-PCR and Sanger sequencing. Drug resistance mutation (DRM) interpretation reports the presence of mutations related to protease inhibitors (PIs), Nucleoside reverse-transcriptase inhibitors (NRTI) and Non-nucleoside reverse-transcriptase inhibitors (NNRTI) based on analysis using Stanford HIV database program...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107869/measles-outbreaks-in-the-kyeongin-area-of-the-republic-of-korea-2013-2014-a-single-center-experience-in-a-country-of-measles-elimination
#6
Sun Hyoung Park, Dong Hun Lee, Jang Yong Jin, Young-Lim Shin, Meeyong Shin, Sung Shin Kim, Won Suk Suh, Jae Ock Park, Yong Hee Hong
OBJECTIVE: To identify the source of infection and determine the clinical features and laboratory finding of measles infection. METHODS: In 27 measles patients, except for 3 adult patients, the rest of 24 pediatric measles cases were analyzed with regard to age, sex, immunization status, transmission routes and molecular genotyping of measles virus. Eighteen measles patients who admitted in isolation ward were set apart to investigate clinical findings and its correlation with laboratory characteristics...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107868/effect-of-ppar%C3%AE-agonist-rosiglitazone-on-the-secretion-of-th2-cytokine-in-asthma-mice
#7
Ji-Hui Yu, Li Long, Zhi-Xiao Luo, Jie-Ru You
OBJECTIVE: To explore the effect of PPARγ agonist (rosiglitazone) on the secretion of Th2 cytokines and the proportion of immune cell subsets in asthma mice. METHODS: Ovalbumin (OVA)-sensitized mice were used to build asthma models. Those mice were divided into the normal control group, model group and rosiglitazone group. Differences of the changes in lung histopathology of mice in the three groups were observed through hematoxylin and eosin (HE) strain, and the numbers of the total cells, eosinophils and neutrophils in BALF of mice in the three groups were compared...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107867/an-update-on-the-2014-ebola-outbreak-in-western-africa
#8
REVIEW
Haaris A Shiwani, Rebabonye B Pharithi, Barkat Khan, Christian Binoun-A Egom, Peter Kruzliak, Vincent Maher, Emmanuel Eroume-A Egom
The recent Ebola outbreak in Western Africa was the most devastating outbreak witnessed in recent times. There have been remarkable local and international efforts to control the crisis. Ebola Virus Disease is the focus of immense research activity. The progression of events in the region has been evolving swiftly and it is of paramount importance to the medical community to be acquainted with the situation. Over 28000 people were inflicted with the condition, over 11000 have died. Novel data has emerged regarding modes of transmission, providing rationale for recent flare-ups...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107866/potential-of-zimbabwean-commercial-probiotic-products-and-strains-of-lactobacillus-plantarum-as-prophylaxis-and-therapy-against-diarrhoea-caused-by-escherichia-coli-in-children
#9
Walter Chingwaru, Jerneja Vidmar
OBJECTIVE: To evaluate the potential of commercial fermented products sold in the country, and strains of Lactobacillus plantarum (L. plantarum) as prophylaxis and therapy against diarrhoea in children. METHODS: The antimicrobial potential of cultures of lactobacilli enriched from 4 Zimbabwean commercial food/beverage products: Dairibord Lacto sour milk (DLSM), Probrand sour milk (PSM), Kefalos Vuka cheese (KVC) and Chibuku opaque beer (COB); and four strains of L...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107865/adipose-tissue-derived-stem-cells-ameliorates-dermal-fibrosis-in-a-mouse-model-of-scleroderma
#10
Wei Chen, Zhi-Kuan Xia, Man-Hui Zhang, Gui-Chun Ding, Xiao-Yan Zhang, Zheng-Xu Wang, Rong-Ya Yang
OBJECTIVE: To investigate the therapeutic potential of adipose-derived stem cells (ADSCs) for limited cutaneous scleroderma (LS) in mouse models. METHODS: ADSCs were isolated from pathogen-free female C57BL/6 mice and LS was induced in wild type (WT) C57BL/6 mice via daily injection of bleomycin (0.1 mL × 300 μg/mL) for 4 weeks; then the ADSCs were subcutaneously injected into the dorsal area in the model treatment group, and 100 μL of phosphate-buffered saline (PBS) solution was injected into the same site in the model control group...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107864/evaluating-the-safety-of-forsythin-from-forsythia-suspensa-leaves-by-acute-and-sub-chronic-oral-administration-in-rodent-models
#11
Zhong Han, Xia-Ling Lei, Hong Zhang, Lu Liu, Zhi-Sen Chen, Wei Yang, Zhao-Rong Lun
OBJECTIVE: To access the toxicity of forsythin from Forsythia suspensa leaves and evaluate its safety. METHODS: Acute toxicity was determined by oral administration of a single dose of 18100 mg/kg forsythin in NIH mice. Sub-chronic toxicity was evaluated by oral administration of several doses of forsythin for 30 days at does of 0, 540, 1620, and 6480 mg/kg in SD rats. RESULTS: In the acute toxicity study, mortality was not observed after 14 days...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107863/first-isolation-of-glutinol-and-a-bioactive-fraction-with-good-anti-inflammatory-activity-from-n-hexane-fraction-of-peltophorum-africanum-leaf
#12
Salmon A Adebayo, Leshweni J Shai, Jacobus N Eloff
OBJECTIVE: To investigate the anti-inflammatory activity of different fractions and glutinol (isolated compound), using nitric oxide synthase and cyclooxygenase (COX) inhibition as an indication of anti-inflammatory activity. METHODS: Anti-inflammatory activity was evaluated using an in vitro assay determining the inhibition of the activity of pro-inflammatory enzyme model. Cyclooxygenases and inducible nitric oxide synthase are crucial enzymes involved in the pathogenesis of many chronic inflammatory conditions...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107862/neuroprotective-effect-of-spilanthes-acmella-murr-on-pesticide-induced-neuronal-cells-death
#13
Wilasinee Suwanjang, Bongkot Khongniam, Sujittra Srisung, Supaluk Prachayasittikul, Virapong Prachayasittikul
OBJECTIVE: To investigate protective effects of Spilanthes acmella (S. acmella) Murr. extracts against pesticide-induced neuronal cells death and to elucidate the underlying molecular mechanism in dopaminergic (SH-SY5Y) cells lines. METHODS: Cell viability of SH-SY5Y cells was studied by treating the cells with various concentration of pirimicarb for 24 h. Neuroprotective effect of S. acmella Murr. extracts was investigated by adding the plant extracts to the medium for 24 h prior to the incubation with 100 μM H2O2 or with pirimicarb for 24 h...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107861/antileishmanial-activities-of-caffeic-acid-phenethyl-ester-loaded-plga-nanoparticles-against-leishmania-infantum-promastigotes-and-amastigotes-in%C3%A2-vitro
#14
Emrah Sefik Abamor
OBJECTIVE: To investigate and compare the antileishmanial effects of CAPE and (CAPE)PLGA NPs on Leishmania infantum (L. infantum) promastigotes and amastigotes in vitro. METHODS: Efficacies of CAPE, (CAPE)PLGA NPs and free PLGA nanoparticles (NPs) on promastigotes were evaluated using MTT and promastigote count assays, and their anti-amastigote effects were determined via infection index analysis. Griess reaction was also performed to calculate nitric oxide production of macrophages exposed to investigated molecules...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107860/the-role-of-heme-oxygenase-1-in-pathogenesis-of-cerebral-malaria-in-the-co-culture-model-of-human-brain-microvascular-endothelial-cell-and-itg-plasmodium-falciparum-infected-red-blood-cells
#15
Pimwan Thongdee, Kesara Na-Bangchang
OBJECTIVE: To investigate the role of human host heme-oxygenase-1 (HO-1) in pathogenesis of cerebral malaria in the in vitro model. METHODS: The effect of human host HO-1 [human brain microvascular endothelial cell (HBMEC)] on hemoglobin degradation in the co-culture model of HBMEC and ITG Plasmodium falciparum-infected red cells (iRBC) through measurement of the enzymatic products iron and bilirubin. RESULTS: Following exposure to the HO-1 inducer CoPPIX at all concentrations, the HBMEC cells apoptosis occurred, which could be prominently observed at 15 μM of 3 h exposure...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107859/dengue-fever-may-mislead-the-surgeons-when-it-presents-as-an-acute-abdomen
#16
Bingumal Jayasundara, Lalith Perera, Ajith de Silva
OBJECTIVE: To review the management experience of a consecutive series of patients presenting as acute surgical abdomen whom were ultimately diagnosed to have DF (Dengue fever)/DHF (Dengue hemorrhagic fever). METHODS: Clinical data of all cases of apparent acute abdomen (AA) which were later confirmed as having DF/DHF reviewed by two surgical units from December 2012 to December 2013 were analyzed. Initially confirmed patients with DF/DHF who developed abdominal symptoms were not considered...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107858/serodiagnosis-of-asymptomatic-dengue-infection
#17
REVIEW
Supawat Chatchen, Arunee Sabchareon, Chukiat Sirivichayakul
Dengue virus (DENV) is a mosquito-transmitted virus that is expanding across the world. The incidence of dengue infection, especially severe disease, has been increasing. DENV consist of 4 serotypes of single stranded RNA viruses (D1-D4) in the genus Flavivirus, family Flaviviridae. Majority of dengue infections are asymptomatic cases, which cause difficulty in disease control and are important in dengue surveillance. There is still no gold standard to diagnose asymptomatic dengue infection. Plaque reduction neutralization test (PRNT) has been developed for many purposes such as immunological study, clinical study, vaccine trial and is currently the most sensitive and specific method for serological surveillance...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107857/prostatic-abscess-of-klebsiella%C3%A2-pneumonia-complicating-septic-pulmonary-emboli-and-meningitis-a-case-report-and-brief-review
#18
Jai-Wen Liu, Tzu-Chieh Lin, Yao-Tien Chang, Che-An Tsai, Sung-Yuan Hu
Prostatic abscess is a rare entity with an incidence of 0.5%-2.5% in all prostate diseases and usually occurs in the 5th and 6th decades of life with immunocompromised status. Prostatic abscess might be a process of evolution from acute prostatitis. Klebsiella pneumoniae is the leading microorganism in the diabetic patients of prostatic abscess in Taiwan. A 60-year-old diabetic man, with a one-week history of acute bacterial prostatitis was reported in this study, presenting to the emergency department with sudden altered mental status...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107856/zika-virus-from-a-southeast-asian-perspective
#19
REVIEW
Nitwara Wikan, Duncan R Smith
Phylogenic evidence suggests that the strain of Zika virus causing an unprecedented outbreak of disease in the Americas had its origin in Southeast Asia, where reports of isolated cases of Zika virus infection have occurred since 2010. Why there has been no large outbreak of Zika infection in Southeast Asia remains unclear and whether such an outbreak will occur in the future is a question of significant concern. This review looks at Zika virus from a Southeast Asian perspective and highlights some of the possible scenarios with regards to Zika virus in this part of the world as well as highlighting some of the research questions that need to be urgently addressed...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27955752/seronegative-disseminated-bartonella-spp-infection-in-an-immunocompromised-patient
#20
Claudia Weilg, Olguita Del Aguila, Fernando Mazulis, Wilmer Silva-Caso, Carlos Alva-Urcia, Rosario Cerpa-Polar, Erick Mattos-Villena, Juana Del Valle Mendoza
An 11 year old, hispanic girl with a history of B-cell acute lymphoblastic leukemia was admitted to the hospital for symptoms compatible with Bartonella henselae infection. The first molecularly diagnosed case of disseminated Bartonella henselae infection was reported in an immunocompromised patient in Lima, Peru. The analysis was confirmed by Polymerase Chain Reaction and automated sequencing of a liver biopsy sample, even though the serologic tests were negative. In conclusion, Bartonella spp. infection should have a particular diagnostic consideration in immunocompromised patients with fever of unknown origin and further investigation regarding the patient's past exposures with cats should also be elicited...
December 2016: Asian Pacific Journal of Tropical Medicine
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