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Asian Pacific Journal of Tropical Medicine

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September 2016: Asian Pacific Journal of Tropical Medicine
Hui-Lei Wan, Hui-Zhi Chen, Xiu-Qin Shi
OBJECTIVE: To study the effects of Traditional Chinese Medicine Jianpi Chushi decoction and ointment on chronic eczema. METHODS: DNCB acetone solution was used to sensitize the skin of back and ears of 36 rats in order to establish chronic eczema model. A total of 36 rats were divided into four groups of 9 randomly including oral medicine group, external inunctum group, combination therapy group, and model control group respectively. Besides, the blank group of 4 healthy rats were set...
September 2016: Asian Pacific Journal of Tropical Medicine
Adil Coskun, Erdogan Malatyali, Hatice Ertabaklar, Mustafa B Yasar, Ali O Karaoglu, Sema Ertug
OBJECTIVE: To determine Blastocystis frequency and subtypes (ST) in ulcerative colitis (UC) patients and analyse some laboratory findings between Blastocystis positive and negative cases. METHODS: Faecal samples from 150 UC patients in Adnan Menderes University, Training and Research Hospital were examined by direct microscopy and cultivated in Jones medium. Blastocystis positive cultures were subjected to DNA isolation and subtypes were identified by sequencing of barcode region...
September 2016: Asian Pacific Journal of Tropical Medicine
Jun-Cheng Guo, Zhi-Liang Tian, Xiao-Dan Wang, Min Guo, Meng-Yong-Wei Li, Yun-Suo Gao, Xiang-Ling Jiang, Lin-Mei Fu, Tao Huang, Xiang Li, Shu-Feng Yu, Li You
OBJECTIVE: To investigate residents' psychological stress factors and research the correlation between post-traumatic stress disorder (PTSD) and platelet 5-HT concentrations so as to provide scientific bases for diagnosis and treatment of PTSD and psychological intervention for people in the disaster area. METHODS: A questionnaire survey of 5500 residents who have accepted psychological help was conducted by the emphatic investigation method. While high performance liquid chromatography was used to detect the platelet serotonin concentration of 100 PTSD patients and 100 healthy people...
September 2016: Asian Pacific Journal of Tropical Medicine
Arshad Javaid, Mazhar Ali Khan, Mir Azam Khan, Sumaira Mehreen, Anila Basit, Raza Ali Khan, Muhammad Ihtesham, Irfan Ullah, Afsar Khan, Ubaid Ullah
OBJECTIVE: To assess the profile of TB/multidrug-resistant TB (MDR-TB) among household contacts of MDR-TB patients. METHODS: Close contacts of MDR-TB patients were traced in the cross-sectional study. Different clinical, radiological and bacteriological were performed to rule out the evidence of TB/MDR-TB. RESULTS: Between January 2012 and December 2012, a total of 200 index MDR-TB patients were initiated on MDR-TB treatment, out of which home visit and contacts screening were conducted for 154 index cases...
September 2016: Asian Pacific Journal of Tropical Medicine
Ali Al Bshabshe, Martin R P Joseph, Ali Al Hussein, Waleed Haimour, Mohamed E Hamid
OBJECTIVE: To identify and to determine the antimicrobial susceptibility of Acinetobacter baumannii (A. baumannii) clinical isolates from ICU at Aseer Central Hospital. METHODS: The study was conducted in the Intensive Care Unit, Aseer Central Hospital, Saudi Arabia over 13 months period (2014-2015). Acinetobacter species (n = 105) were isolated from various clinical samples. Isolates were identified using selected phenotypic criteria and confirmed using the Vitek 2 automated system...
September 2016: Asian Pacific Journal of Tropical Medicine
Chang-Jiang Lei, Chun Yao, De-Ke Li, Zhi-Xiong Long, Yuan Li, Dan Tao, Yan-Ping Liou, Jiang-Zhou Zhang, Ning Liu
OBJECTIVE: To investigate the effects of co-transfection of miR-520c-3p and miR-132 on proliferation and apoptosis of hepatocellular carcinoma Huh7. METHODS: Hepatocellular carcinoma Huh7 was cultured in vitro and lipidosome was used to transfect miR-520c-3p and miR-132, respectively or together. The effects of transfection of miR-520c-3p and miR-132 on proliferation and apoptosis of Huh7 were detected by CCK8 and Annexin V staining and flow cytometry, and the expression level of the targeted gene of over-expressed miR-520c-3p and miR-132 was determined by Western blot and realtime PCR...
September 2016: Asian Pacific Journal of Tropical Medicine
Qiao-Min Wu, Hai-Xiang Ni, Xiao Lu
OBJECTIVE: To study the effect of sitagliptin on adipocytokines expression in diabetic rats and its molecular mechanism. METHODS: Male SD rats were chosen and randomly divided into NC group, T2DM group, SP group and SP + LY group. NC group received conventional breeding, T2DM group, SP group and SP + LY group received intraperitoneal injection of streptozotocin after 12 weeks of high-fat diet to establish diabetes animal model, SP group received sitagliptin intervention and SP + LY group received sitagliptin combined with PI3K inhibitor LY294002 intervention...
September 2016: Asian Pacific Journal of Tropical Medicine
Tahereh Mikaeili Galeh, Abdolhassan Kazemi, Mahmoud Mahami-Oskouei, Behzad Baradaran, Adel Spotin, Seddigheh Sarafraz, Majid Karamat
OBJECTIVE: To identify the frequencies (F) of ferredoxin and nitroreductase mutations on Iranian clinical isolates of Giardia lamblia in order to predict whether the nitazoxanide can be prescribed as suitable drug for symptomatic to metronidazole-resistant giardiasis. METHODS: Forty Giardia lamblia isolates as of 38 symptomatic and two metronidazole-resistant patients were collected from Iran. DNAs were extracted and amplified by targeting ferredoxin and GlNR genes...
September 2016: Asian Pacific Journal of Tropical Medicine
Ling Huang, Jun-Qing Zhang, You-Bin Li, Mi Liu, Hui-Ming Deng, Yu-Chao Luo, Yin-Feng Tan, Jie Hou, Gui-Wei Yao, Wei-Wei Guan
OBJECTIVE: To study the effect of Alpinia officinarum Hance (A. officinarum) 80% alcohol extract on the primary dysmenorrhea. METHODS: A. officinarum 80% alcohol extract were enriched by macroporous adsorption resins. Female mice of primary dysmenorrhea model were established by oxytocin induction; the effects of A. officinarum 80% alcohol extract on primary dysmenorrhea were observed by body twist method; and the homogenate level of prostaglandin F2α (PGF2α), prostaglandin E2 (PGE2) and Ca(2+) in the uterus were observed in oxytocin-induced female mice...
September 2016: Asian Pacific Journal of Tropical Medicine
Bang-Jiang Fang, Jun-Yi Shen, Hua Zhang, Shuang Zhou, Chuan-Zhu Lyu, Yi-Qiang Xie
OBJECTIVE: To study the mechanism of insulin resistance in the cholesterol gallstone formation from insulin signal transduction pathway so as to reveal the possible mechanism and the effective role of Albiflorin Granule on preventing the cholesterol gallstones. METHODS: Serum triglycerides (TG), free fatty acid (FFA), and total cholesterol (TC) from different groups were measured and liver cells InsR, PKB, IKK-β protein expression levels were detected by western blotting...
September 2016: Asian Pacific Journal of Tropical Medicine
Yun-Xia Zhang, Ya Su, Li Tang, Ze-Xing Yang, Dai-Feng Zhou, Yi-Min Qiu, Wang-Wei Cai
OBJECTIVE: In this paper, we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island. METHODS: We tested the TaqIB and I405V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package (Version 19.0). RESULTS: Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P < 0...
September 2016: Asian Pacific Journal of Tropical Medicine
Tooba Mahboob, Abdul-Majid Azlan, Tian-Chye Tan, Chandramathi Samudi, Shamala Devi Sekaran, Veeranoot Nissapatorn, Christophe Wiart
OBJECTIVE: To examine the acanthamoebicidal effects of ethyl acetate, aqueous and butanol fractions of dried flower buds of Lonicera japonica (L. japonica) Thunb. (Flos Lonicerae) in vitro. METHODS: Acanthamoeba triangularis isolates were obtained from environmental water samples and identified by PCR. They were exposed to ethyl acetate, water and butanol fractions of L. japonica Thunb. at concentrations ranging from 0.5 mg/mL to 1.5 mg/mL. The extracts were evaluated for growth inhibition at 24, 48 and 72 h, respectively...
September 2016: Asian Pacific Journal of Tropical Medicine
Áurea Regina Telles Pupulin, Lívia Bracht, Márcia Machado de Oliveira Dalalio, Francielli Maria de Souza Silva-Comar, Bruno Ambrósio da Rocha, Franciele Queiroz Ames, Roberto Kenji Nakamura Cuman, Ciomar Aparecida Bersani-Amado
OBJECTIVE: To identify whether Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y strain. METHODS: Animals were divided into five groups: non-treated infected animals (I); benznidazole-treated infected animals (Bz; 100 mg/kg body weight, single daily dose by gavage); Canova medication (CM) treated infected animals (CM; 0.2 mL/animal, single daily dose by gavage); benznidazole- and Canova medication-treated infected animals with the above-mentioned dose (Bz+CM); and non-infected animals (C)...
September 2016: Asian Pacific Journal of Tropical Medicine
Pimwan Thongdee, Jiraporn Kuesap, Raewadee Wisedpanichkij, Kesara Na-Bangchang
OBJECTIVE: To preliminarily investigate the possible role of prostaglandin D2 (PGD2) in malaria infections. METHODS: Blood and urinary samples (n = 120 each) were collected from Thai patients with Plasmodium falciparum (P. falciparum) with moderate (n = 26) and high (n = 4) parasitemia, patients with Plasmodium vivax (P. vivax) (n = 30), patients with fever associated with other infections (n = 30), and healthy subjects (n = 30). PGD2 concentrations in plasma and urinary samples of healthy subjects, patients with fever associated with other infections and patients with malaria were determined using Prostaglandin D2-MOX express EIA kit (Cayman Chemical, USA)...
September 2016: Asian Pacific Journal of Tropical Medicine
Jia B Kangbai
OBJECTIVE: To explore and visualize the connectivity of suspected Ebola cases and surveillance callers who used cellphone technology in Moyamba District in Sierra Leone for Ebola surveillance, and to examine the demographic differences and characteristics of Ebola surveillance callers who make more calls as well as those callers who are more likely to make at least one positive Ebola call. METHODS: Surveillance data for 393 suspected Ebola cases (192 males, 201 females) were collected from October 23, 2014 to June 28, 2015 using cellphone technology...
September 2016: Asian Pacific Journal of Tropical Medicine
Hamza Dar, Tahreem Zaheer, Muhammad Talha Rehman, Amjad Ali, Aneela Javed, Gohar Ayub Khan, Mustafeez Mujtaba Babar, Yasir Waheed
OBJECTIVE: To predict immunogenic promiscuous T cell epitopes from the polyprotein of the Zika virus using a range of bioinformatics tools. To date, no epitope data are available for the Zika virus in the IEDB database. METHODS: We retrieved nearly 54 full length polyprotein sequences of the Zika virus from the NCBI database belonging to different outbreaks. A consensus sequence was then used to predict the promiscuous T cell epitopes that bind MHC 1 and MHC II alleles using PorPred1 and ProPred immunoinformatic algorithms respectively...
September 2016: Asian Pacific Journal of Tropical Medicine
Filippo Fratini, Giovanni Cilia, Barbara Turchi, Antonio Felicioli
Beeswax is the substance that forms the structure of a honeycomb; the bees secrete wax to build the honeycombs where to store honey. Thanks to its rich hydrophobic protective properties, the beeswax is in fact present within cosmetics and body products. Also, beeswax is used in the food industry: as a film to wrap cheese for maturing or as a food additive (E901) to give shine to the products. Exactly as the honey which it contains, beeswax is also characterized by several therapeutic properties of great interest to us; it is thought to be particularly effective in healing bruises, inflammation and burns...
September 2016: Asian Pacific Journal of Tropical Medicine
Walter Chingwaru, Richard H Glashoff, Jerneja Vidmar, Petrina Kapewangolo, Samantha L Sampson
Mycobacterium tuberculosis and human immunodeficiency virus (HIV) co-infections have remained a major public health concern worldwide, particularly in Southern Africa. Yet our understanding of the molecular interactions between the pathogens has remained poor due to lack of suitable preclinical models for such studies. We reviewed the use, this far, of mammalian cell culture models in HIV-MTB interaction studies. Studies have described the use of primary human cell cultures, including (1) monocyte-derived macrophage (MDM) fractions of peripheral blood mononuclear cell (PBMC), alveolar macrophages (AM), (2) cell lines such as the monocyte-derived macrophage cell line (U937), T lymphocyte cell lines (CEMx174, ESAT-6-specific CD4(+) T-cells) and an alveolar epithelial cell line (A549) and (3) special models such as stem cells, three dimensional (3D) or organoid cell models (including a blood-brain barrier cell model) in HIV-MTB interaction studies...
September 2016: Asian Pacific Journal of Tropical Medicine
Mohammad Rahimi-Madiseh, Afsaneh Malekpour-Tehrani, Mahmoud Bahmani, Mahmoud Rafieian-Kopaei
Diabetes mellitus can damage the eyes, kidneys, nerves and heart. Microvascular and macrovascular disorders are the leading causes of morbidity and mortality in diabetic patients. Hyperglycemia can increase the indicators of lipid peroxidation and oxidative stress in which free radicals have the main role in the pathogenesis of these complications. Therefore, antioxidants which combat oxidative stress should be able to prevent and repair free radicals induced damages. Although free radicals contribute to kidney damage, atherosclerosis, diabetes, heart disease, nephrotoxicity and hepatotoxicity; however, clinical trials do not uniquely confirm a substantial impact on diabetic damage...
September 2016: Asian Pacific Journal of Tropical Medicine
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