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Asian Pacific Journal of Tropical Medicine

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https://www.readbyqxmd.com/read/29268979/polyphenolic-content-in%C3%A2-vitro-antioxidant-activity-and-chemical-composition-of-extract-from-nephelium-lappaceum-l-mexican-rambutan-husk
#1
Cristian Hernández, Juan Ascacio-Valdés, Heliodoro De la Garza, Jorge Wong-Paz, Cristóbal Noé Aguilar, Guillermo Cristian Martínez-Ávila, Cecilia Castro-López, Antonio Aguilera-Carbó
OBJECTIVE: To determinate the recovery of total polyphenolic compounds content, in vitro antioxidant activity and HPLC/ESI/MS characterization of extract from Nephelium lappaceum L. (Mexican rambutan). METHODS: The rambutan husk extract was obtained by aqueous extraction and a polyphenolic fraction was recovered using Amberlite XAD-16. The total polyphenolic compounds content was determined by the Folin Ciocalteu and butanol-HCI methods. In vitro antioxidant activity was performed using ABTS and ferric reducing antioxidant power methods...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268978/electrophysiological-changes-of-autonomic-cells-in-left-ventricular-outflow-tract-in-guinea-pigs-with-iron-deficiency-anemia-complicated-with-chronic-heart-failure
#2
Ling Fan, Li-Feng Chen, Jing Fan
OBJECTIVE: To investigate the electrophysiological changes of autonomic cells in left ventricular outflow tract in guinea pigs with iron deficiency anemia complicated with chronic heart failure. METHODS: Guinea pigs model of iron deficiency anemia complicated with chronic heart failure in 10 guinea pigs of the experimental group was made by feeding a low iron diet, pure water and subcutaneous injection of isoproterenol. The control group consisting of 11 guinea pigs was given normal food, normal water and injected with normal saline...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268977/reverse-effect-of-curcumin-on-cddp-induced-drug-resistance-via-keap1-p62-nrf2-signaling-in-a549-cddp-cell
#3
Jie Shen, Ya-Juan Chen, Yuan-Wei Jia, Wen-Ying Zhao, Guang-Hai Chen, Ding-Feng Liu, Yun-Yu Chen, Chao Zhang, Xiao-Ping Liu
OBJECTIVE: To assess the effect of curcumin on CDDP-induced drug resistance and explore the underlying molecular mechanism through Nrf2 system and autophagy pathway. METHODS: A drug-resistant cell model was established by exposing A549/CDDP cell to 2 μg/mL CDDP. A549/CDDP cell was treated with 20 μg/mL CDDP and 10 μM curcumin. The cell viability and apoptosis level, the signals of Keap1/P62-Nrf2 and autophagy pathway were analyzed. RESULTS: CDDP induction promoted drug-resistant phenotype in A549/CDDP cell and activated autophagy as well as Nrf2 signals in A549/CDDP cell...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268976/expression-of-vimentin-and-glial-fibrillary-acidic-protein-in-central-nervous-system-development-of-rats
#4
Hua Luo, Xiao-Qiong Wu, Min Zhao, Qiong Wang, Geng-Pan Jiang, Wei-Jun Cai, Ming-Ying Luo
OBJECTIVE: To investigate the distribution and contents of vimentin (Vim) and glial fibrillary acidic protein (GFAP) immunoreactivities in the central nervous system (CNS) of normal newborn, adult and aged rats. METHODS: In this study, thirty healthy and normal Sprague-Dawley rats were simply classified into three groups: Newborn (7 days aged), adult (5 months aged) and aged (24 months aged) rats. Brains and spinal cord were dissected and cut into frozen sections...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268975/development-of-a-mouse-model-of-arecoline-induced-oral-mucosal-fibrosis
#5
Qi-Tao Wen, Tao Wang, Da-Hai Yu, Zheng-Rui Wang, Ying Sun, Cui-Wei Liang
OBJECTIVE: To develop a BALB/c mouse model of oral submucous fibrosis (OSF) induced by arecoline and to exhibit an accumulation of collagen and angiogenesis changes. METHODS: BALB/c mice were randomly assigned to either the control (distilled water) or experimental group (arecoline) (n = 40). Eight mice from each group were sacrificed every 4 weeks since 8 weeks post treatment. Changes in histopathologic features, levels of collagen type I and collagen type III, and angiogenesis were measured...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268974/regulating-effect-of-glycyrrhetinic-acid-on-bronchial-asthma-smooth-muscle-proliferation-and-apoptosis-as-well-as-inflammatory-factor-expression-through-erk1-2-signaling-pathway
#6
Tao Zhang, Jia-Yi Liao, Li Yu, Guo-Sheng Liu
OBJECTIVE: To study the influence of glycyrrhetinic acid (GA) on bronchial asthma (BA) smooth muscle proliferation and apoptosis as well as inflammatory factor expression and its molecular mechanism. METHODS: Male SD guinea pigs were selected and made into asthma models, bronchial asthma smooth muscle cells were cultured and divided into BA group, GA group and GA + LM group that were treated with serum-free RPMI1640 culture medium, serum-free RPMI1640 culture medium containing 50 ng/mL glycyrrhetinic acid, serum-free RPMI1640 culture medium containing 50 ng/mL glycyrrhetinic acid and 100 ng/mL LM22B-10 respectively; normal guinea pigs were collected and bronchial smooth muscle cells were cultured as control group...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268973/faunal-data-and-envenomation-emergency-first-aid-of-cone-snails-conus-spp-in-qeshm-island-the-persian-gulf
#7
Mehdi Khoobdel, Hadi Dehghani, Ali Mehrabi Tavana, Mohammad Ghasemi, Seyyed Mohammad Dakhteh, Majid Askari Hesni, Mohsen Rezaie-Atagholipour
OBJECTIVE: To investigate the fauna of a highly venomous marine species group, the cone snails (Family Conidae), in the shores of Qeshm Island, of evaluating the possibility of envenomation in the area and summarize recommendations for emergency first aid. METHODS: Shores surrounding Qeshm Island were surveyed to collect cone snails during cold (February and March) and warm (May and June) seasons of 2017. Collected snails were identified to the species level. Abundance and species richness were estimated in shores of different structures, including muddy and sandy-rocky shores...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268972/some-pathogenic-characters-of-paratyphoid-salmonella-enterica-strains-isolated-from-poultry
#8
Fabrizio Bertelloni, Giovanni Tosi, Paola Massi, Laura Fiorentini, Maria Parigi, Domenico Cerri, Valentina Virginia Ebani
OBJECTIVE: To investigate some pathogenic characters of Salmonella enterica strains isolated from poultry. METHODS: Twenty-three genetically distinct Salmonella enterica strains, of different serovars and pulsotype, were examined for virulence traits. Resistance to gastric acid environment was estimated by measuring the percentage of survived bacterial cells after exposure for 2 h to a synthetic gastric juice. Strains were analyzed with PCR for the presence of the following virulence genes: mgtC and rhuM located on SPI-3, sopB and pipB located on SPI-5, Salmonella virulence plasmid (spv) R (spvR), spvB and spvC located on Salmonella plasmid virulence and sodCI, sopE, and gipA located on prophage...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268971/antibiofilm-activity-of-%C3%AE-mangostin-extracted-from-garcinia-mangostana-l-against-staphylococcus-aureus
#9
Nguyen Thi Mai Phuong, Ngo Van Quang, Ta Thu Mai, Nguyen Vu Anh, Chutima Kuhakarn, Vichai Reutrakul, Albert Bolhuis
OBJECTIVE: To isolate α-mangostin (AMG) from the peels of mangosteen (Garcinia mangostana L.), grown in Vietnam, and to investigate antibiofilm activity of this compound against three Staphylococcus aureus (S. aureus) strains, one of which was methicillin-resistant S. aureus (MRSA) and the other two strains were methicillin-sensitive S. aureus (MSSA). METHODS: AMG in n-hexane fraction was isolated on a silica gel column and chemically analyzed by HPLC and NMR...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268970/pharmacological-evaluation-of-smooth-muscle-relaxant-and-cardiac-modulation-potential-of-phyla-nodiflora-in-ex-vivo-and-in-vivo-experiments
#10
Hafiz Muhammad Abdur Rahman, Khaled Ahmed, Muhammad Fawad Rasool, Imran Imran
OBJECTIVE: To investigate the pharmacological basis of its uses of Phyla nodiflora (P. nodiflora) for the treatment of anomalies predominantly by smooth muscle containing tissues such as gastrointestinal/vascular/broncho spasm and cardiovascular modulation. METHODS: The crude hydroalcoholic extract of P. nodiflora (Pn.Cr) and its fractions were evaluated on isolated rabbit jejunum, rat trachea, aorta and atrium. To access the contractile or relaxant effects of testing materials, the tissues were mounted in isolated organ bath and responses were recorded with transducers coupled with data acquisition system...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268969/bacteriocin-like-inhibitory-substance-blis-activity-of-streptococcus-macedonicus-mbf10-2-and-its-synergistic-action-in-combination-with-antibiotics
#11
Sharon Edith Grazia, Sumayyah Sumayyah, Fakhri Subhana Haiti, Muhamad Sahlan, Nicholas C K Heng, Amarila Malik
OBJECTIVE: To characterize the bacteriocin-like inhibitory-substances (BLIS) activity of Streptococcus macedonicus MBF10-2 [named BLIS(MBF10-2)], a bacteriocinogenic strain isolated from an Indonesian tofu byproduct. METHODS: BLIS(MBF10-2) was obtained by culturing the bacterium, and standard deferred antagonism assays were used to demonstrate its activity. The antibacterial testing of fractions collected by filtration using 3-30 kDa cut-off membrane sizes were carried out by performing well diffusion method...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268968/phytochemical-analysis-and-biological-activities-of-hertia-cheirifolia-l-roots-extracts
#12
Kaouther Majouli, Assia Hamdi, Malek Besbes Hlila
OBJECTIVE: To test the antioxidant, antimicrobial and α-glucosidase inhibitory activities of the roots extracts from Hertia cheirifolia (H. cheirifolia) L. METHODS: Total phenolics and total flavonoids content of the different extracts were determined by colorimetric methods and reverse phase high-performance liquid chromatography (RP-HPLC) was performed to identify various chemical components. The different extracts were evaluated for antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis-3-ethylenebenzothiozoline-6-sulfonic acid (ABTS+) and β-carotene bleaching tests and α-glucosidase inhibitory properties...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268967/rescue-effects-of-aqueous-seed-extracts-of-foeniculum-vulgare-and-carum-carvi-against-cadmium-induced-hepatic-renal-and-gonadal-damage-in-female-albino-rats
#13
Ahmed Abdel-Wahab, Abdel-Razik Hashem Abdel-Razik, Rabie Lotfy Abdel Aziz
OBJECTIVE: To investigate the protective effects of aqueous seed extracts of fennel "Foeniculum vulgare" (FVE) and caraway "Carum carvi" (CCE) on liver, kidney and reproductive organs in female rats against cadmium chloride (CC) intoxication. METHODS: A total of 36 adult female rats were divided into six groups, six in each group. Control group (fed normal diet), CC-treated group (50 mg CC/kg diet), CCE-treated group (150 mg CCE/kg diet), CCE + CC group, FVE (150 mg/kg diet) and FVE + CC...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268966/comparative-molecular-docking-studies-of-lupeol-and-lupenone-isolated-from-pueraria-lobata-that-inhibits-bace1-probable-remedies-for-alzheimer-s-disease
#14
Prashamsa Koirala, Su Hui Seong, Hyun Ah Jung, Jae Sue Choi
OBJECTIVE: To discover lead lupane triterpenoid's potential isolated from Pueraria lobata roots against β-site amyloid precursor protein cleaving enzyme 1 (BACE1), which serve as a rate limiting step in amyloid beta (Aβ) production altering the course of Alzheimer's disease. In addition, enzyme kinetics study and molecular docking were conducted to establish the inhibition type and structure activity relationship. METHODS: A systematic study of 70% ethanolic P...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268965/antioxidants-friend-or-foe
#15
REVIEW
R Sarangarajan, S Meera, R Rukkumani, P Sankar, G Anuradha
Reactive oxygen species are the intermediates that are formed during the normal metabolic process which are effectively neutralized by the antioxidant system of the body. Any imbalance in this neutralization process causes oxidative stress which has been implicated as one of the cause in diseases such as Alzheimer's disease, cardiovascular disorders, cancer etc. Research has enabled the use of antioxidants as therapeutic agents in the treatment of various diseases. Literature also puts forth the negative effects of using antioxidants in the treatment of diseases...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29268964/natural-compounds-and-extracts-from-mexican-medicinal-plants-with-anti-leishmaniasis-activity-an-update
#16
REVIEW
Gabriel Alfonso Gutiérrez-Rebolledo, Susan Drier-Jonas, María Adelina Jiménez-Arellanes
Leishmaniasis is considered as an emerging, uncontrolled disease and is endemic in 98 countries. Annually, about 2 million cases of cutaneous and 500000 cases of visceral-type leishmaniasis are recorded and 60000 persons died from the disease. In Mexico, cutaneous leishmaniasis is known as chiclero's ulcer and is reported in 22 states, it is considered as a health problem. For its treatment, pentavalent antimonial drugs are administered. These drugs cause severe side effects, are costly. Drug-resistant cases have been reported and have been developing for over 70 years...
December 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29203110/an-atypical-case-of-disseminated-cutaneous-leishmaniasis-due-to-leishmania-peruviana-in-the-valleys-of-ancash-peru
#17
Diego Espinoza-Morales, Aldo Lucchetti Rodríguez, Wilmer Silva-Caso, Luis Suarez-Ognio, María J Pons, Juana Del Valle Mendoza
We present an atypical case of disseminated cutaneous leishmaniasis in the Sihuas district, located in the Andean valleys of Ancash-Peru. A 62-year-old man with no particular medical history presented multiple lesions located on the inferior abdomen, lumbar region and the right anterior thigh. Histological analysis found leishmanial amastigotes in the lesion sample, the Montenegro reaction was positive for Leishmania spp, and the polymerase chain reaction was positive for Leishmania peruviana. In conclusion, the atypical presentation of this disease may be related to the presence of an uncommon parasite strain or host immune deficiencies...
November 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29203109/influence-of-light-intensity-and-water-content-of-medium-on-total-dendrobine-of-dendrobium-nobile-lindl
#18
Jin-Ling Li, Zhi Zhao, Hong-Chang Liu, Chun-Li Luo, Hua-Lei Wang
OBJECTIVE: To ascertain the influence of light intensity and water content of medium on the total dendrobine of Dendrobium nobile (D. nobile). METHOD: The principal component analysis combined with total dendrobine accumulation was conducted to assess the yield and quality of D. nobile in all treatments. In the experiment, D. nobile plants were cultivated in greenhouse as tested materials, and complete test of 9 treatments was adopted with relative light intensities 75...
November 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29203108/effect-of-taurine-on-immune-function-in-mice-with-t-cell-lymphoma-during-chemotherapy
#19
Jin-Feng Dong, Xiao-Qiang Zheng, Hong-Bing Rui
OBJECTIVE: To observe the effect of taurine on immune function in mice with T-cell lymphoma during chemotherapy. METHODS: A total of 40 C57BL/6 mice were selected and randomly divided into 4 groups, namely model group, chemotherapy group, taurine group and chemotherapy + taurine group, each containing 10 mice. Hypodermic injection was adopted to inoculate EL-4 cells in order to establish model of T-cell lymphoma. When the tumor achieved the size of 1 cm3, intervention treatments were given to the groups respectively...
November 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29203107/glypican-3-specific-cytotoxic-t-lymphocytes-induced-by-human-leucocyte-antigen-a-0201-restricted-peptide-effectively-kill-hepatocellular-carcinoma-cells-in%C3%A2-vitro
#20
Jiang-Zheng Zeng, Yu Liu, Fen Huang, Zhi-Hui He, Huamao Sun, Yan-Da Lu, Jun-Hua Lei, Rong-Cheng Luo
OBJECTIVE: To investigate potential human leucocyte antigen (HLA)-A2-restricted epitope peptides of glypican-3 (GPC3) and determine the cytotoxicity of peptide-specific cytotoxic T lymphocytes (CTLs) against hepatocellular carcinoma (HCC) cells. METHODS: The potential HLA-A*0201-restricted GPC3 peptides were screened using computer algorithms, T2 cell-binding affinity and stability of peptide/HLA-A*0201 complex assay. The peptide-specific CTLs were generated and their cytotoxicity against GPC3+ SMMC 7721 and HepG2 cells was detected using IFN-γ based enzyme-linked immunospot and lactate dehydrogenase release assays in vitro...
November 2017: Asian Pacific Journal of Tropical Medicine
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