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Anesthesiology Research and Practice

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https://www.readbyqxmd.com/read/27895665/sugammadex-enhanced-neuronal-apoptosis-following-neonatal-sevoflurane-exposure-in-mice
#1
Maiko Satomoto, Zhongliang Sun, Yushi U Adachi, Koshi Makita
In rodents, neonatal sevoflurane exposure induces neonatal apoptosis in the brain and results in learning deficits. Sugammadex is a new selective neuromuscular blockade (NMB) binding agent that anesthesiologists can use to achieve immediate reversal of an NMB with few side effects. Given its molecular weight of 2178, sugammadex is thought to be unable to pass through the blood brain barrier (BBB). Volatile anesthetics can influence BBB opening and integrity. Therefore, we investigated whether the intraperitoneal administration of sugammadex could exacerbate neuronal damage following neonatal 2% sevoflurane exposure via changes in BBB integrity...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27882047/perioperative-elevation-in-cell-free-dna-levels-in-patients-undergoing-cardiac-surgery-possible-contribution-of-neutrophil-extracellular-traps-to-perioperative-renal-dysfunction
#2
Yu Qi, Tokujiro Uchida, Mamoru Yamamoto, Yudai Yamamoto, Koji Kido, Hiroyuki Ito, Nagara Ohno, Miho Asahara, Yoshitsugu Yamada, Osamu Yamaguchi, Chieko Mitaka, Makoto Tomita, Koshi Makita
Background. This study aimed to determine the perioperative change in serum double-strand DNA (dsDNA) as a marker potentially reflecting neutrophil extracellular trap concentration in samples from patients undergoing cardiac surgery and to analyze a relationship between serum dsDNA concentrations and perioperative renal dysfunction. Methods. Serum dsDNA concentrations in samples that were collected during a previously conducted, prospective, multicenter, observational study were measured. Eighty patients undergoing elective cardiac surgery were studied...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27847515/the-ambu%C3%A2-aura-i%C3%A2-laryngeal-mask-and-lma-supreme%C3%A2-a-randomized-trial-of-clinical-performance-and-fibreoptic-positioning-in-unparalysed-anaesthetised-patients-by-novices
#3
Zanahriah Yahaya, Wendy H Teoh, Nora A Dintan, Ravi Agrawal
Introduction. Manikin studies' data cannot accurately be extrapolated to real-life scenarios and inherent differences in design and materials of newer products may affect their clinical performance. Methods. Hence, we compared the AMBU® Aura-i™ and LMA Supreme™ in this randomized trial involving 100 ASA 1-2 unparalysed anaesthetised patients undergoing minor gynaecological surgery. Investigators had <20 Aura-i insertions. Primary outcome was time to achieve effective ventilation and secondarily insertion parameters, oropharyngeal leak pressures (OLP), fibreoptic positioning, and pharyngeal morbidity...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27818682/current-trends-in-neuromuscular-blockade-management-and-monitoring-amongst-singaporean-anaesthetists
#4
Wendy H Teoh, Thomas Ledowski, Phillip S Tseng
Introduction. This survey aimed to investigate the attitudes/practice pertaining the use, management, and monitoring of neuromuscular blockade amongst Singaporean anaesthetists. Methods. All specialist accredited anaesthetists registered with the Singapore Medical Council were invited to complete an anonymous online survey. Results. The response rate was 39.5%. Neuromuscular monitoring (NM) was used routinely by only 13.1% despite the widespread availability of monitors. 82% stated residual NMB (RNMB) was a significant risk factor for patient outcome, but only 24% believed NMB monitoring should be compulsory in all paralyzed patients...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27777585/time-trends-and-predictors-of-abnormal-postoperative-body-temperature-in-infants-transported-to-the-intensive-care-unit
#5
Hedwig Schroeck, Angela K Lyden, Wendy L Benedict, Satya Krishna Ramachandran
Background. Despite increasing adoption of active warming methods over the recent years, little is known about the effectiveness of these interventions on the occurrence of abnormal postoperative temperatures in sick infants. Methods. Preoperative and postoperative temperature readings, patient characteristics, and procedural factors of critically ill infants at a single institution were retrieved retrospectively from June 2006 until May 2014. The primary endpoints were the incidence and trend of postoperative hypothermia and hyperthermia on arrival at the intensive care units...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27635132/hypnosis-in-the-perioperative-management-of-breast-cancer-surgery-clinical-benefits-and-potential-implications
#6
REVIEW
Arnaud Potié, Fabienne Roelants, Audrey Pospiech, Mona Momeni, Christine Watremez
The aim of this review is to summarize data published on the use of perioperative hypnosis in patients undergoing breast cancer surgery (BCS). Indeed, the majority of BCS patients experience stress, anxiety, nausea, vomiting, and pain. Correct management of the perioperative period and surgical removal of the primary tumor are clearly essential but can affect patients on different levels and hence have a negative impact on oncological outcomes. This review examines the effect of clinical hypnosis performed during the perioperative period...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27630712/the-effect-of-dexmedetomidine-on-lumbar-epidural-injection-for-failed-back-surgery-syndrome
#7
Ashraf Eskandr, Sadik Abdel Maseeh
Purpose. Failed back surgery syndrome is a chronic pain condition requiring rapid, effective, and efficient management. This study evaluates the effect of adding dexmedetomidine to lumbar epidural steroids in patients with failed back surgery syndrome. Methods. Fifty patients suffering from failed back surgery syndrome were randomly assigned to one of two groups, receiving an epidural injection of 20 mL of either a mixture of betamethasone (14 mg) and bupivacaine 0.5 mg (group C) or a mixture of betamethasone (14 mg), bupivacaine 0...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27610133/length-of-stay-in-ambulatory-surgical-oncology-patients-at-high-risk-for-sleep-apnea-as-predicted-by-stop-bang-questionnaire
#8
Diwakar D Balachandran, Saadia A Faiz, Mike Hernandez, Alicia M Kowalski, Lara Bashoura, Farzin Goravanchi, Sujith V Cherian, Elizabeth Rebello, Spencer S Kee, Katy E French
Background. The STOP-BANG questionnaire has been used to identify surgical patients at risk for undiagnosed obstructive sleep apnea (OSA) by classifying patients as low risk (LR) if STOP-BANG score < 3 or high risk (HR) if STOP-BANG score ≥ 3. Few studies have examined whether postoperative complications are increased in HR patients and none have been described in oncologic patients. Objective. This retrospective study examined if HR patients experience increased complications evidenced by an increased length of stay (LOS) in the postanesthesia care unit (PACU)...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27478436/intubation-success-through-i-gel%C3%A2-and-intubating-laryngeal-mask-airway%C3%A2-using-flexible-silicone-tubes-a-randomised-noninferiority-trial
#9
Latha Naik, Neerja Bhardwaj, Indu Mohini Sen, Rakesh V Sondekoppam
Introduction. The study aims to test whether flexible silicone tubes (FST) improve performance and provide similar intubation success through I-Gel as compared to ILMA. Our trial is registered in CTRI and the registration number is "CTRI/2016/06/006997." Methods. One hundred and twenty ASA status I-II patients scheduled for elective surgical procedures needing tracheal intubation were randomised to endotracheal intubation using FST through either I-Gel or ILMA. In the ILMA group (n = 60), intubation was attempted through ILMA using FST and, in the I-Gel group (n = 60), FST was inserted through I-Gel airway...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27429615/the-effect-of-patient-weight-and-provider-training-and-experience-on-dosing-of-rocuronium
#10
N C Godwin, L Rodriguez, S Banks, B T Major, Y Rodriguez
Introduction. Maintenance dosing of neuromuscular blocking agents is complex and varies with patient, procedure, and clinical situation. With this in mind, we sought to identify factors impacting the maintenance dosing of neuromuscular blockers as a step toward identifying best practice with respect to minimizing residual neuromuscular blockade. Methods. Cases utilizing rocuronium from July 1, 2010, to June 30, 2014, at the sponsoring institution were analyzed. Using a mixed model to account for repeated measures, patients were analyzed by dose and weight category as defined by the World Health Organization (eight categories ranging from very severely underweight to very severely obese) as well as by the administering provider's level of experience...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27382368/comparison-of-medical-adhesive-tapes-in-patients-at-risk-of-facial-skin-trauma-under-anesthesia
#11
Ling Antonia Zeng, Sui An Lie, Shin Yuet Chong
Introduction. Adhesive tapes are used for taping eyelids closed and securing endotracheal tubes during general anesthesia. These tapes can cause facial skin injury. We compared the incidence of facial skin injury and patient satisfaction with different tapes used. Methods. A total of 60 adult patients at risk of skin trauma were randomized to use 3M™ Kind Removal Silicone Tape or standard acrylate tapes: 3M Durapore (endotracheal tube) and Medipore (eyelids). Patients were blinded to tape used. Postoperatively, a blinded recovery nurse assessed erythema, edema, and denudation of skin...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27313608/effects-of-addition-of-systemic-tramadol-or-adjunct-tramadol-to-lidocaine-used-for-intravenous-regional-anesthesia-in-patients-undergoing-hand-surgery
#12
Abdulkadir Yektaş, Funda Gümüş, Abdulhalim Karayel, Ayşin Alagöl
Intravenous regional anesthesia (IVRA) is used in outpatient hand surgery as an easily applicable and cost-effective technique with clinical advantages. The present study aimed to investigate the effects of addition of systemic tramadol or adjunct tramadol to lidocaine for IVRA in patients undergoing hand surgery. American Society of Anesthesiologists (ASA) I-II patients (n = 60) who underwent hand surgery were included. For this purpose, only lidocaine (LDC), lidocaine+adjunct tramadol (LDC+TRA group), or lidocaine+systemic tramadol (LDC+SysTRA group) was administered to the patients for IVRA and the groups were compared in terms of onset and recovery time of sensory and motor blocks, quality of anesthesia, and the degree of intraoperative and postoperative pain...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27293430/development-and-testing-of-screen-based-and-psychometric-instruments-for-assessing-resident-performance-in-an-operating-room-simulator
#13
Richard R McNeer, Roman Dudaryk, Nicholas B Nedeff, Christopher L Bennett
Introduction. Medical simulators are used for assessing clinical skills and increasingly for testing hypotheses. We developed and tested an approach for assessing performance in anesthesia residents using screen-based simulation that ensures expert raters remain blinded to subject identity and experimental condition. Methods. Twenty anesthesia residents managed emergencies in an operating room simulator by logging actions through a custom graphical user interface. Two expert raters rated performance based on these entries using custom Global Rating Scale (GRS) and Crisis Management Checklist (CMC) instruments...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27293429/comparison-of-the-success-of-two-techniques-for-the-endotracheal-intubation-with-c-mac-video-laryngoscope-miller-blade-in-children-a-prospective-randomized-study
#14
Renu Sinha, Ankur Sharma, Bikash Ranjan Ray, Ravinder Kumar Pandey, Vanlalnghka Darlong, Jyotsna Punj, Chandralekha Chandralekha, Ashish Datt Upadhyay
Background. Ease of endotracheal intubation with C-MAC video laryngoscope (VLS) with Miller blades 0 and 1 has not been evaluated in children. Methods. Sixty children weighing 3-15 kg with normal airway were randomly divided into two groups. Intubation was done with C-MAC VLS Miller blade using either nonstyletted endotracheal tube (ETT) (group WS) or styletted ETT (group S). The time for intubation and total procedure, intubation attempts, failed intubation, blade repositioning or external laryngeal maneuver, and complications were recorded...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27143966/a-prospective-cohort-study-evaluating-the-ability-of-anticipated-pain-perceived-analgesic-needs-and-psychological-traits-to-predict-pain-and-analgesic-usage-following-cesarean-delivery
#15
Brendan Carvalho, Ming Zheng, Scott Harter, Pervez Sultan
Introduction. This study aimed to determine if preoperative psychological tests combined with simple pain prediction ratings could predict pain intensity and analgesic usage following cesarean delivery (CD). Methods. 50 healthy women undergoing scheduled CD with spinal anesthesia comprised the prospective study cohort. Preoperative predictors included 4 validated psychological questionnaires (Anxiety Sensitivity Index (ASI), Fear of Pain (FPQ), Pain Catastrophizing Scale, and Eysenck Personality Questionnaire) and 3 simple ratings: expected postoperative pain (0-10), anticipated analgesic threshold (0-10), and perceived analgesic needs (0-10)...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27110239/percutaneous-nephrolithotomy-current-clinical-opinions-and-anesthesiologists-perspective
#16
REVIEW
Indira Malik, Rachna Wadhwa
Percutaneous nephrolithotomy (PCNL), a minimally invasive method for removal of renal calculi, was initially started in the 1950s but gained popularity about two decades later and has now become standard practice for management. There has been an immense improvement in technique and various guidelines have been established for treatment of renal stones. However, it has its own share of complications which can be attributed to surgical technique as well as anesthesia related complications. PubMed and Google search yielded more than 30 articles describing the different complications seen in this procedure, out of which 15 major articles were selected for writing this review...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27110238/comparison-of-ondansetron-and-dexamethasone-for-prophylaxis-of-postoperative-nausea-and-vomiting-in-patients-undergoing-laparoscopic-surgeries-a-meta-analysis-of-randomized-controlled-trials
#17
REVIEW
Souvik Maitra, Anirban Som, Dalim K Baidya, Sulagna Bhattacharjee
Background. Postoperative nausea and vomiting (PONV) is a significant complication after laparoscopic surgeries. Ondansetron and dexamethasone are most commonly used drugs for PONV prophylaxis. Comparisons of these two drugs have not been systematically reviewed till date. Methods. PubMed, PubMed Central, and CENTRAL databases were searched with the following words: "dexamethasone," "ondansetron," "laparoscopy," and "PONV" to identify randomized trials that compared ondansetron and dexamethasone for PONV prophylaxis after laparoscopic surgeries...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27073395/leakage-characteristics-of-dual-cannula-fenestrated-tracheostomy-tubes-during-positive-pressure-ventilation-a-bench-study
#18
Thomas Berlet, Mathias Marchon
This study compared the leakage characteristics of different types of dual-cannula fenestrated tracheostomy tubes during positive pressure ventilation. Fenestrated Portex® Blue Line Ultra®, TRACOE® twist, or Rüsch® Traceofix® tracheostomy tubes equipped with nonfenestrated inner cannulas were tested in a tracheostomy-lung simulator. Transfenestration pressures and transfenestration leakage rates were measured during positive pressure ventilation. The impact of different ventilation modes, airway pressures, temperatures, and simulated static lung compliance settings on leakage characteristics was assessed...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27051421/dexmedetomidine-versus-magnesium-sulfate-as-adjunct-during-anesthesia-for-laparoscopic-colectomy
#19
Pierre Zarif, Ahmed Abdelaal Ahmed Mahmoud, Mohamed Mohamed Abdelhaq, Hany M S Mikhail, Ahmed Farag
Objectives. To compare dexmedetomidine versus magnesium during laparoscopic colectomy. Patients and Methods. 51 patients were randomly allocated into 3 groups: group C (control) received saline infusion, group D dexmedetomidine 1 g/kg and then 0.4 g/kg/hr, and group M MgSO4 2 g and then 15 g/kg/min. Intraoperative hemodynamics were measured before and 1 min after intubation (T1 and T2), before and 5 min after peritoneal insufflation (T3 and T4), before and 5 min after 30° Trendelenburg position (T5 and T6), 5 min after resuming flat position (T7), 5 min after peritoneal deflations (T8), after extubation (T9), and at time of admission to PACU (T10)...
2016: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/27034662/comparative-evaluation-of-pain-scores-during-periodontal-probing-with-or-without-anesthetic-gels
#20
Ashank Mishra, Mandapathi Priyanka, Koppolu Pradeep, Krishnajaneya Reddy Pathakota
Context. The initial periodontal examination which includes full-mouth periodontal probing is one of the discomforting procedures for a patient. Aim. To evaluate the efficacy of two local anesthetic gels in the reduction of pain during periodontal probing using Florida probe in CGP patients in comparison with manual probing. Materials and Methods. Ninety systemically healthy patients with moderate to severe CGP patients were recruited. In each patient, the quadrants were randomly assigned to manual probing with UNC-15 probe, probing with Florida probe, and Florida probing with lidocaine 10% gel and with benzocaine 20% gel...
2016: Anesthesiology Research and Practice
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