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https://www.readbyqxmd.com/read/30237865/correction-antibody-targeting-tspan12-%C3%AE-catenin-signaling-in-vasoproliferative-retinopathy
#1
Felicitas Bucher, Martin Friedlander, Kyungmoo Yea
[This corrects the article DOI: 10.18632/oncotarget.23401.].
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237864/prevalence-of-mdm2-amplification-and-coalterations-in-523-advanced-cancer-patients-in-the-md-anderson-phase-1-clinic
#2
Vikas Dembla, Neeta Somaiah, Pedro Barata, Kenneth Hess, Siqing Fu, Filip Janku, Daniel D Karp, Aung Naing, Sarina Anne Piha-Paul, Vivek Subbiah, Apostolia M Tsimberidou, Kenna Shaw, Funda Meric-Bernstam, David S Hong
Background: TP53 is the most commonly mutated gene in cancer and codes for the best studied tumor suppressor, p53. MDM2 is involved in the negative regulation of p53 and itself serves as an oncogene, reported to be overexpressed in several cancer tumor types. In this retrospective study, we assessed the occurrence of MDM2 amplification among patients with various types of cancers and its association with clinical factors, other genetic aberrations, and response to targeted therapy in a phase I clinical trial setting...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237863/hematopoietic-stem-cell-specific-v-atpase-controls-breast-cancer-progression-and-metastasis-via-cytotoxic-t-cells
#3
Manoranjan Sahoo, Gajendra K Katara, Mahmood Y Bilal, Safaa A Ibrahim, Arpita Kulshrestha, Sara Fleetwood, Kimiko Suzue, Kenneth D Beaman
The interaction of recruited immune effector cells and cancer cells within tumor microenvironment (TME) shapes the fate of cancer progression and metastasis. Many cancers including breast cancer, express a specific vacuolar ATPase (a2V) on their cell surface which acidifies the extracellular milieu helping cancer cell proliferation and metastasis. To understand the role of immune cell-associated-a2V during breast tumor pathogenesis, we knocked-out a2V (KO) from the hematopoietic stem cells (HSC) and generated breast tumors in mice...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237862/biochemical-and-cellular-consequences-of-the-antithrombin-p-met1-mutation-identified-in-a-severe-thrombophilic-family
#4
José Navarro-Fernández, María Eugenia de la Morena-Barrio, Emma Martínez-Alonso, Ingunn Dybedal, Mara Toderici, Nataliya Bohdan, Antonia Miñano, Ketil Heimdal, Ulrich Abildgaard, José Ángel Martínez-Menárguez, Javier Corral, Vicente Vicente
Nature is always the best inspiration for basic research. A family with severe thrombosis and antithrombin deficiency, the strongest anticoagulant, carried a new mutation affecting the translation-start codon of SERPINC1 , the gene encoding antithrombin. Expression of this variant in a eukaryotic cell system produced three different antithrombins. Two downstream methionines were used as alternative initiation codons, generating highly expressed small aglycosylated antithrombins with cytoplasmic localization...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237861/mir-665-targets-c-myc-and-hdac8-to-inhibit-murine-neuroblastoma-cell-growth
#5
Nagindra Prashad
Neuroblastoma is a common tumor of the peripheral nervous system in children. Highly aggressive MYC-driven neuroblastoma is defined by increased c-MYC and/or MYCN expression. This study employed a mouse neuroblastoma cell model to assess the role of miR-665 in tumorigenesis. We found that miR-665 suppresses mRNAs, targeting c-MYC and HDAC8, which are involved in neuroblastoma tumorigenesis. N6,2'-O-dibutyryladenosine 3':5'cyclic monophosphate (Bt2cAMP) inhibited neuroblastoma cell growth by inhibiting c-MYC and HDAC8 expression and activating caspase 3...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237860/autotaxin-%C3%AE-interaction-with-the-cell-surface-via-syndecan-4-impacts-on-cancer-cell-proliferation-and-metastasis
#6
Raphael Leblanc, Debashish Sahay, Audrey Houssin, Irma Machuca-Gayet, Olivier Peyruchaud
Autotaxin (ATX) promotes cancer cell metastasis through the production of lysophosphatidic acid (LPA). ATX binds to αvβ3 integrins controlling metastasis of breast cancer cells. We screened a series of cancer cell lines derived from diverse human and mouse solid tumors for the capacity of binding to ATX and found only a modest correlation with their level of αvβ3 integrin expression. These results strongly suggested the existence of another cell surface ATX-interacting factor. Indeed, ATXα has been shown to bind heparan-sulfate chains because of its unique polybasic insertion sequence, although the biological significance is unknown...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237859/prediction-of-non-muscle-invasive-bladder-cancer-recurrence-by-measurement-of-checkpoint-hlag-s-receptor-ilt2-on-peripheral-cd8-t-cells
#7
Francois Desgrandchamps, Joel LeMaoult, Annabelle Goujon, Adrien Riviere, Antonio Rivero-Juarez, Malika Djouadou, Amory de Gouvello, Clement Dumont, Ching-Lien Wu, Stephane Culine, Jerome Verine, Nathalie Rouas-Freiss, Christophe Hennequin, Alexandra Masson-Lecomte, Edgardo D Carosella
Background and Objective: Recurrence of non-muscle invasive bladder cancer (NMIBC) after initial management occurs in 60-70% of patients. Predictive criteria for recurrence remain only clinical and pathological. The aim of this study was to investigate the prognostic significance of the proportion of checkpoint HLA-G's receptor ILT2-expressing peripheral CD8+ T cells. Results: The proportion of CD4+ ILT2+ and CD8+ ILT2+ T cells was not increased in NMIBC compared to controls...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237858/comprehensive-analysis-identifying-aberrant-dna-methylation-in-rectal-mucosa-from-ulcerative-colitis-patients-with-neoplasia
#8
Yuji Toiyama, Yoshinaga Okugawa, Satoru Kondo, Yoshiki Okita, Toshimitsu Araki, Kurando Kusunoki, Motoi Uchino, Hiroki Ikeuchi, Seiichi Hirota, Akira Mitsui, Kenji Takehana, Tsutomu Umezawa, Masato Kusunoki
Background: There are no biomarkers to facilitate the identification of patients with ulcerative colitis (UC) who are at high risk for developing colorectal cancer (CRC). In our current study, we used rectal tissues from UC patients to identify aberrant DNA methylations and evaluated whether they could be used to identify UC patients with coexisting colorectal neoplasia. Results: Using a training set, we identified 484 differentially methylated regions (DMRs) with absolute delta beta-values > 0...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237857/trisenox-disrupts-mdm2-daxx-hausp-complex-and-activates-p53-cell-cycle-regulation-and-apoptosis-in-acute-leukemia-cells
#9
Sanjay Kumar, Andrea Brown, Paul B Tchounwou
Trisenox (TX) has been used in the treatment of both de novo and relapsed acute promyelocytic leukemia (APL) patients. Using in vitro APL cell lines model in this research, we report on a new target of TX action through disruption of MDM2-DAXX-HAUSP complex, degradation of MDM2, and activation of p53 expression. TX-induced stress signal was transmitted by protein kinase (ATM & ATR) and phosphorylation of its downstream targets CHK1, CHK2, ATM, and ATR, respectively at the Ser 345, Thr68, Ser1981 and Ser 428 residues involved in complex disruption and p53 up-regulation...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237856/fludarabine-resistance-associates-with-ceramide-metabolism-and-leukemia-stem-cell-development-in-chronic-lymphocytic-leukemia
#10
Chunfa Huang, Yifan Tu, Carl E Freter
Fludarabine (flu) -containing regimens such as flu, cyclophosphamide and rituximab have been established as one of the standard first line therapy in medically-fit chronic lymphocytic leukemia (CLL) patients. Therefore, flu-refractory (primary flu-insensitivity or flu-caused relapse) remains a major problem causing treatment failure for CLL patients. We isolated the peripheral blood mononuclear cells (PBMCs) from CLL patients and treated with flu to find flu-refractory cases, and established flu-resistant clonal cells to study molecular mechanism of flu-resistance...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237855/the-jumonji-domain-histone-demethylase-inhibitor-jib-04-deregulates-oncogenic-programs-and-increases-dna-damage-in-ewing-sarcoma-resulting-in-impaired-cell-proliferation-and-survival-and-reduced-tumor-growth
#11
Janet K Parrish, Tyler S McCann, Marybeth Sechler, Lays M Sobral, Wenhua Ren, Kenneth L Jones, Aik Choon Tan, Paul Jedlicka
Ewing Sarcoma is an aggressive malignant neoplasm affecting children and young adults. Ewing Sarcoma is driven by transcription factor fusion oncoproteins, most commonly EWS/Fli1. While some patients can be cured with high-dose, multi-agent, chemotherapy, those that cannot currently have few options. Targeting of the driver oncofusion remains a logical therapeutic approach, but has proven difficult. Recent work has pointed to epigenetic mechanisms as key players, and potential new therapeutic targets, in Ewing Sarcoma...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237854/investigation-of-novel-chemotherapeutics-for-feline-oral-squamous-cell-carcinoma
#12
Hunter John Piegols, Marilia Takada, Maciej Parys, Thomas Dexheimer, Vilma Yuzbasiyan-Gurkan
Feline oral squamous cell carcinomas (FOSCC) are highly aggressive neoplasms with short survival times despite multimodal treatment. FOSCC are similar to squamous cell carcinomas of the head and neck (SCCHN) in humans, which also present therapeutic challenges. The current study was undertaken to identify novel chemotherapeutics using FOSCC cell lines. A high throughput drug screen using 1,952 drugs was performed to identify chemotherapeutics for further investigation. Two of the drugs identified in the drug screen, actinomycin D and methotrexate, and two drugs with similar molecular targets to drugs found to be efficacious in the screening, dinaciclib and flavopiridol, were selected for further investigation...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237853/distinct-urinary-glycoprotein-signatures-in-prostate-cancer-patients
#13
Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R M Leite, Morten Thaysen-Andersen, Martin R Larsen, Giuseppe Palmisano
Novel biomarkers are needed to complement prostate specific antigen (PSA) in prostate cancer (PCa) diagnostic screening programs. Glycoproteins represent a hitherto largely untapped resource with a great potential as specific and sensitive tumor biomarkers due to their abundance in bodily fluids and their dynamic and cancer-associated glycosylation. However, quantitative glycoproteomics strategies to detect potential glycoprotein cancer markers from complex biospecimen are only just emerging. Here, we describe a glycoproteomics strategy for deep quantitative mapping of N - and O -glycoproteins in urine with a view to investigate the diagnostic value of the glycoproteome to discriminate PCa from benign prostatic hyperplasia (BPH), two conditions that remain difficult to clinically stratify...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237852/mtorc1-2-inhibition-re-sensitizes-platinum-resistant-ovarian-cancer-by-disrupting-selective-translation-of-dna-damage-and-survival-mrnas
#14
Gizelka David-West, Amanda Ernlund, Abhilash Gadi, Robert J Schneider
Platinum resistance is a major cause of treatment failure and mortality in epithelial ovarian cancer. mTORC1/2 inhibitors, which impair mRNA translation, can re-sensitize resistant ovarian cancer cells to platinum chemotherapy but the mechanism remains poorly described. Using platinum-resistant OVCAR-3 cells treated with the selective mTORC1/2 inhibitor INK128/MLN128, we conducted genome-wide transcription and translation studies and analyzed the effect on cell proliferation, AKT-mTOR signaling and cell survival, to determine whether carboplatin resistance involves selective mRNA translational reprogramming, and whether it is sensitive to mTORC1/2 inhibition...
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237851/population-based-germline-testing-for-primary-cancer-prevention
#15
COMMENT
Ranjit Manchanda, Rosa Legood
No abstract text is available yet for this article.
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237850/prognostic-markers-for-colorectal-cancer
#16
EDITORIAL
Helen E J Tyrrell, David Kerr
No abstract text is available yet for this article.
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237849/-177-lutetium-dotatate-delays-decline-in-quality-of-life-in-patients-with-midgut-neuroendocrine-tumors
#17
EDITORIAL
Jonathan Strosberg
No abstract text is available yet for this article.
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237848/-macrod2-deletions-cause-impaired-parp1-activity-and-chromosome-instability-in-colorectal-cancer
#18
EDITORIAL
Anuratha Sakthianandeswaren, Marie J Parsons, Dmitri Mouradov, Oliver M Sieber
No abstract text is available yet for this article.
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237847/checks-and-balances-occur-not-only-in-government-but-also-in-biology
#19
EDITORIAL
John T Isaacs
No abstract text is available yet for this article.
September 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/30237846/cpg-island-hypermethylation-go-circular-rna
#20
COMMENT
Mihnea P Dragomir, George A Calin
No abstract text is available yet for this article.
September 4, 2018: Oncotarget
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