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https://www.readbyqxmd.com/read/28455955/sphingosine-kinase-2-and-multiple-myeloma
#1
EDITORIAL
Nigel J Pyne, Susan Pyne
News on: Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress, by Wallington-Beddoe et al. Oncotarget. 2017; doi: 10.18632/oncotarget.17115.
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455964/bispecific-protein-targets-prostate-cancer
#2
EDITORIAL
Antony W Burgess
News on: PSMA-homing dsRNA chimeric protein vector kills prostate cancer cells and activates anti-tumor bystander responses, by Langut et al. Oncotarget. 2017; 8:24046-62. doi: 10.18632/oncotarget.15733.
April 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418932/bmpr1b-mutation-causes-pierre-robin-sequence
#3
Yongjia Yang, Jianying Yuan, Xu Yao, Rong Zhang, Hui Yang, Rui Zhao, Jihong Guo, Ke Jin, Haibo Mei, Yongqi Luo, Liu Zhao, Ming Tu, Yimin Zhu
BACKGROUND: We investigated a large family with Pierre Robin sequence (PRS). AIM OF THE STUDY: This study aims to determine the genetic cause of PRS. RESULTS: The reciprocal translocation t(4;6)(q22;p21) was identified to be segregated with PRS in a three-generation family. Whole-genome sequencing and Sanger sequencing successfully detected breakpoints in the intragenic regions of BMRP1B and GRM4. We hypothesized that PRS in this family was caused by (i) haploinsufficiency for BMPR1B or (ii) a gain of function mechanism mediated by the BMPR1B-GRM4 fusion gene...
April 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455963/trkc-promotes-colorectal-cancer-growth-and-metastasis
#4
Min Soo Kim, Kwang Wook Suh, Suntaek Hong, Wook Jin
The current work reveals that TrkC receptor is crucial to many aspects of tumorigenicity and metastasis of cancer. However, with only a few exceptions, such as colorectal cancer (CRC), where suppressing tumorigenic and metastatic ability via expression of TrkC as tumor suppressor have been proposed. These diverse lines of evidence led us to investigate whether TrkC is involved in CRC progression. By using mouse models and molecular biology analyses, we demonstrate that TrkC acts as an activator in tumorigenicity and metastasis of colorectal cancer...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455962/runx1-and-breast-cancer
#5
EDITORIAL
Jose Mercado-Matos, Asia N Matthew-Onabanjo, Leslie M Shaw
News on: Runx1 stabilizes the mammary epithelial cell phenotype and prevents epithelial to mesenchymal transition, by Hong et al. Oncotarget. 2017; 8:17610-27. doi: 10.18632/oncotarget.15381.
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455961/repositioning-chlorpromazine-for-treating-chemoresistant-glioma-through-the-inhibition-of-cytochrome-c-oxidase-bearing-the-cox4-1-regulatory-subunit
#6
Claudia R Oliva, Wei Zhang, Cathy Langford, Mark J Suto, Corinne E Griguer
Patients with glioblastoma have one of the lowest overall survival rates among patients with cancer. Standard of care for patients with glioblastoma includes temozolomide and radiation therapy, yet 30% of patients do not respond to these treatments and nearly all glioblastoma tumors become resistant. Chlorpromazine is a United States Food and Drug Administration-approved phenothiazine widely used as a psychotropic in clinical practice. Recently, experimental evidence revealed the anti-proliferative activity of chlorpromazine against colon and brain tumors...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454122/olaparib-in-combination-with-irinotecan-cisplatin-and-mitomycin-c-in-patients-with-advanced-pancreatic-cancer
#7
Mark Yarchoan, Melinda C Myzak, Burles A Johnson Iii, Ana De Jesus-Acosta, Dung T Le, Elizabeth M Jaffee, Nilofer S Azad, Ross C Donehower, Lei Zheng, Paul E Oberstein, Robert L Fine, Daniel A Laheru, Michael Goggins
BACKGROUND: Olaparib is an oral inhibitor of polyadenosine 5'-diphosphoribose polymerization (PARP) that has previously shown signs of activity in patients with BRCA mutations and pancreatic ductal adenocarcinoma (PDAC). RESULTS: 18 patients with unresectable PDAC were enrolled. The MTD of olaparib plus IC was olaparib 100 mg twice-daily on days 1 and 8. The addition of mitomycin C to this dose level was not tolerated. Grade ≥3 drug-related adverse events (AEs) were encountered in 16 patients (89%)...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455954/galectin-1-expression-imprints-a-neurovascular-phenotype-in-proliferative-retinopathies-and-delineates-responses-to-anti-vegf
#8
Magali E Ridano, Paula V Subirada, María C Paz, Valeria E Lorenc, Juan C Stupirski, Ana L Gramajo, José D Luna, Diego O Croci, Gabriel A Rabinovich, María C Sánchez
Neovascular retinopathies are leading causes of irreversible blindness. Although vascular endothelial growth factor (VEGF) inhibitors have been established as the mainstay of current treatment, clinical management of these diseases is still limited. As retinal impairment involves abnormal neovascularization and neuronal degeneration, we evaluated here the involvement of galectin-1 in vascular and non-vascular alterations associated with retinopathies, using the oxygen-induced retinopathy (OIR) model. Postnatal day 17 OIR mouse retinas showed the highest neovascular profile and exhibited neuro-glial injury as well as retinal functional loss, which persisted until P26 OIR...
April 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418857/multi-factorial-modulation-of-colorectal-carcinoma-cells-motility-partial-coordination-by-the-tetraspanin-co-029-tspan8
#9
Yingying Zhu, Naouel Ailane, Monica Sala-Valdés, Farhad Haghighi-Rad, Martine Billard, Viet Nguyen, Raphael Saffroy, Antoinette Lemoine, Eric Rubinstein, Claude Boucheix, Céline Greco
Colorectal carcinoma cells Isreco1 display an ability to migrate controlled by a complex set of signals issued from the membrane. By comparing cells infected by mycoplasmas and mycoplasmas free cells, we have established that basal 2D migration is dependent on a double signal mediated by the collagen receptors integrins alpha1/2 and the Toll-Like receptor TLR2. The signal issued from mycoplasmas can be replaced by a TLR2 ligand and the functional effect is neutralized by silencing of MyD88. Following previous observation that downregulation of E-cadherin/p120 catenin increases cell motility, we now report that EGFR or CD44 inhibition have a similar effect on cell motility that is restricted to tetraspanin Co-029/tspan8 transduced IsrecoI cells (Is1-Co029)...
April 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423350/atxn2-a-culprit-with-multiple-facets
#10
EDITORIAL
Aurore Nkiliza, Marie-Christine Chartier-Harlin
No abstract text is available yet for this article.
April 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423349/m-channels-and-stress-response
#11
EDITORIAL
Sheng Wang, Fang Yuan, De-Pei Li
No abstract text is available yet for this article.
April 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423348/a-neurorestorative-approach-to-parkinson-s-disease
#12
EDITORIAL
Giovanni Diana, Maria Teresa Ciotti, Marco Musilli
No abstract text is available yet for this article.
April 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28446732/docetaxel-versus-docetaxel-plus-cisplatin-for-non-small-cell-lung-cancer-a-meta-analysis-of-randomized-clinical-trials
#13
REVIEW
Ang Li, Zhi-Jian Wei, Han Ding, Hao-Shuai Tang, Heng-Xing Zhou, Xue Yao, Shi-Qing Feng
OBJECTIVE: To compare the activity, efficacy and toxicity of docetaxel versus docetaxel plus cisplatin in patients with non-small-cell lung cancer. METHODS: A literature search was performed in the EMBASE, Medline, Cochrane Library, Web of Science, China National Knowledge Internet, Wan-fang databases. The trials that were found were then evaluated for eligibility. The Cochrane Collaboration's Review Manager software was used to perform the meta-analyses. RESULTS: Nine clinical trials including 1257 patients were included...
April 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430647/pink1-and-ataxin-2-as-modifiers-of-growth
#14
EDITORIAL
Nesli E Sen, Suzana Gispert, Georg Auburger
No abstract text is available yet for this article.
April 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455994/molecular-profiling-of-colorectal-pulmonary-metastases-and-primary-tumours-implications-for-targeted-treatment
#15
Sing Yu Moorcraft, Thomas Jones, Brian A Walker, George Ladas, E Kalaitzaki, Lina Yuan, Ruwaida Begum, Zakaria Eltahir, Andrew Wotherspoon, Angeles Montero Fernandez, Larissa S Teixeira Mendes, David Gonzalez de Castro, Sanna Hulkki Wilson, Paula Proszek, Ye Mong To, Eliza Hawkes, Amitesh Roy, David Cunningham, Sheela Rao, David Watkins, Naureen Starling, Anne M Bowcock, Ian Chau
This study aimed to molecularly characterise colorectal pulmonary metastases (PM) and investigate whether their molecular profiles were concordant with those of the primary tumour. Clinical data and archival formalin fixed paraffin embedded tissue samples were retrospectively collected from patients who underwent ≥ 1 pulmonary metastasectomies for colorectal cancer between 1997-2012. Primary tumour and metastatic samples were analysed using a targeted capture sequencing panel of 46 cancer-associated genes...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455993/rectovaginal-fistula-after-low-anterior-resection-in-chinese-patients-with-colorectal-cancer
#16
Hongtu Zheng, Tianan Guo, Yuchen Wu, Cong Li, Sanjun Cai, Fangqi Liu, Ye Xu
Rectovaginal fistula is a postoperative complication of low anterior resection. We investigated the incidence of rectovaginal fistula (RVF) after low anterior resection, its risk factors and its optimal treatment. We analyzed data from 1,493 female patients who underwent low anterior resection for colorectal cancer between January 2006 and March 2016. We calculated the incidence of RVF and performed univariate and multivariate logistic regression analyses to identify risk factors. Twenty-four patients experienced RVF, giving an incidence of 1...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455992/microrna-610-suppresses-osteosarcoma-oncogenicity-via-targeting-twist1-expression
#17
Chi Jin, Yongjian Feng, Yongjian Ni, Zhonglin Shan
Osteosarcoma is the most frequent primary bone tumor affects adolescents and young adults. Recently, microRNAs (miRNAs) are short, non-coding and endogenous RNAs that played as important roles in the initiation and progression of tumors. In this study, we try to explore the biological function and expression of miR-610 in the osteosarcoma. We showed that miR-610 expression was downregulated in the osteosarcoma tissues and cell lines. Elevated expression of miR-610 suppressed the osteosarcoma cell proliferation, cell cycle, invasion and EMT program...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455991/trail-r1-as-a-novel-surface-marker-for-circulating-giant-cell-tumor-of-bone
#18
Jian-Xiang Liu, Zhi-Cai Zhang, Zeng-Wu Shao, Fei-Fei Pu, Bai-Chuan Wang, Yu-Kun Zhang, Xian-Lin Zeng, Xiao-Dong Guo, Shu-Hua Yang, Tong-Chuan He
Giant cell tumor of bone (GCT), which frequently occurs in the patients' spine, is relatively prevalent in Chinese population. A group of GCT invades into vessels and appears to be circulating tumor cells (CTCs) responsible for the distal metastasis of the primary tumor. So far the cell surface markers of GCT have not been determined. In the current study, we aimed to identify a novel CTC marker with higher specificity in GCT. TRAIL-R1+ cells were purified from GCT cell lines. The TRAIL-R1+ cells were compared with total GCT cells for tumor sphere formation, chemo-resistance, tumor formation in nude mice, and frequency of developing distal metastases...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455990/sanguinarine-protects-against-osteoarthritis-by-suppressing-the-expression-of-catabolic-proteases
#19
Yan Ma, Xuewu Sun, Kangmao Huang, Shuying Shen, Xianfeng Lin, Ziang Xie, Jiying Wang, Shunwu Fan, Jianjun Ma, Xing Zhao
Inflammatory cytokines play critical roles in the pathogenesis of osteoarthritis. Recent studies have demonstrated that natural active substances can serve as alternative therapeutic agents for the prevention and treatment of osteoarthritis. Sanguinarine, an alkaloid isolated from the roots of Sanguinaria canadensis, is known to have anti-inflammatory properties. The aim of the present study was to investigate the therapeutic effect of Sanguinarine against osteoarthritis. Sanguinarine inhibited interleukin-1β-induced expression of matrix metalloproteinase 1, 3, and 13, and A disintegrin and metalloproteinase with thrombospondin motifs-5 in chondrocytes, which involved the nuclear factor-κB and c-Jun N-terminal kinase signalling pathways...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28455989/polymorphisms-of-pri-mir-219-1-are-associated-with-the-susceptibility-and-prognosis-of-non-small-cell-lung-cancer-in-a-northeast-chinese-population
#20
Chang Zheng, Xuelian Li, Lingzi Xia, Xue Fang, Xiaowei Quan, Zhihua Yin, Yuxia Zhao, Baosen Zhou
Occurrence and development of non-small cell lung cancer (NSCLC) is a complex process affected both by gene and environment. Single nucleotide polymorphisms (SNPs) in microRNAs' (miRNAs) biogenesis influenced the expression of mature miRNAs, further had an impact on risk of NSCLC. Our study focused on the correlation between rs213210, rs421446 or rs107822 polymorphisms in pri-miR-219-1 and susceptibility or prognosis of NSCLC in Chinese. A case-control study of 405 new-diagnosis patients and 405 controls was performed...
April 11, 2017: Oncotarget
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