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Clinical and Experimental Gastroenterology

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https://www.readbyqxmd.com/read/27920566/hcverso1-and-2-faldaprevir-with-deleobuvir-bi-207127-and-ribavirin-for-treatment-na%C3%A3-ve-patients-with-chronic-hepatitis-c-virus-genotype-1b-infection
#1
Christoph Sarrazin, Francesco Castelli, Pietro Andreone, Maria Buti, Massimo Colombo, Stanislas Pol, Filipe Calinas, Massimo Puoti, Antonio Olveira, Mitchell Shiffman, Jerry O Stern, George Kukolj, Michael Roehrle, Stella Aslanyan, Qiqi Deng, Richard Vinisko, Federico J Mensa, David R Nelson
The interferon-free combination of once-daily faldaprevir 120 mg, twice-daily deleobuvir 600 mg, and weight-based ribavirin was evaluated in two Phase III studies (HCVerso1, HCVerso2) in hepatitis C virus genotype-1b-infected, treatment-naïve patients, including those ineligible for peginterferon (HCVerso2). Patients without cirrhosis were randomized to 16 weeks (Arm 1; n=208 HCVerso1, n=213 HCVerso2) or 24 weeks (Arm 2; n=211 in both studies) of faldaprevir + deleobuvir + ribavirin. Patients with compensated cirrhosis received open-label faldaprevir + deleobuvir + ribavirin for 24 weeks (Arm 3; n=51, n=72)...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27826206/necrotizing-pancreatitis-challenges-and-solutions
#2
REVIEW
Victoria A Bendersky, Mohan K Mallipeddi, Alexander Perez, Theodore N Pappas
Acute pancreatitis is a common disease that can progress to gland necrosis, which imposes significant risk of morbidity and mortality. In general, the treatment for pancreatitis is a supportive therapy. However, there are several reasons to escalate to surgery or another intervention. This review discusses the pathophysiology as well as medical and interventional management of necrotizing pancreatitis. Current evidence suggests that patients are best served by delaying interventions for at least 4 weeks, draining as a first resort, and debriding recalcitrant tissue using minimally invasive techniques to promote or enhance postoperative recovery while reducing wound-related complications...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27826205/comparison-of-glasgow-blatchford-score-and-full-rockall-score-systems-to-predict-clinical-outcomes-in-patients-with-upper-gastrointestinal-bleeding
#3
Marjan Mokhtare, Vida Bozorgi, Shahram Agah, Mehdi Nikkhah, Amirhossein Faghihi, Amirhossein Boghratian, Neda Shalbaf, Abbas Khanlari, Hamidreza Seifmanesh
BACKGROUND: Various risk scoring systems have been recently developed to predict clinical outcomes in patients with upper gastrointestinal bleeding (UGIB). The two commonly used scoring systems include full Rockall score (RS) and the Glasgow-Blatchford score (GBS). Bleeding scores were assessed in terms of prediction of clinical outcomes in patients with UGIB. PATIENTS AND METHODS: Two hundred patients (age >18 years) with obvious symptoms of UGIB in the emergency department of Rasoul Akram Hospital were enrolled...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27789969/managing-inflammatory-bowel-disease-in-pregnancy-current-perspectives
#4
REVIEW
Matthew Pinder, Katie Lummis, Christian P Selinger
Inflammatory bowel disease (IBD) affects many women of childbearing age. The course of IBD is closely related to pregnancy outcomes with poorly controlled IBD increasing the risk of prematurity, low weight for gestation, and fetal loss. As such, women with IBD face complex decision making weighing the risks of active disease versus those of medical treatments. This review summarizes the current evidence regarding the safety and efficacy of IBD treatments during pregnancy and lactation aiming to provide up-to-date guidance for clinicians...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27785086/systematic-review-treatment-pattern-and-clinical-effectiveness-and-safety-of-pharmaceutical-therapies-for-crohn-s-disease-in-europe
#5
REVIEW
Filippo Lelli, Solomon Nuhoho, Xin Ying Lee, Weiwei Xu
BACKGROUND: Although many clinical trials have been conducted in treatments of Crohn's disease (CD), whether the trial results were representative of daily practice needs to be supported by studies conducted in real-world settings. AIM: This study aims to identify how CD is treated and what are the clinical effectiveness and safety of the pharmaceutical therapies of CD in real-world settings. METHODS: A systematic literature review was conducted based on Medline(®), Embase(®), and Cochrane...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27703391/cigarette-smoking-adversely-affects-disease-activity-and-disease-specific-quality-of-life-in-patients-with-crohn-s-disease-at-a-tertiary-referral-center
#6
Sandra M Quezada, Patricia Langenberg, Raymond K Cross
PURPOSE: Smoking has a negative impact on disease activity in Crohn's disease (CD). Smoking may also affect the quality of life, but this has not been evaluated using validated measures over time. We assessed the relationship between smoking and disease-specific quality of life over time in a tertiary referral inflammatory bowel disease cohort. PATIENTS AND METHODS: Retrospective cohort study from July 2004 to July 2009 in patients with CD identified from the University of Maryland, Baltimore, Institutional Review Board-approved University of Maryland School of Medicine Inflammatory Bowel Disease Program database...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27703390/splenosis-involving-the-gastric-fundus-a-rare-cause-of-massive-upper-gastrointestinal-bleeding-a-case-report-and-review-of-the-literature
#7
Jason Reinglas, Kirstin Perdrizet, Stephen E Ryan, Rakesh V Patel
Splenosis, the autotransplantation of splenic tissue following splenic trauma, is uncommonly clinically significant. Splenosis is typically diagnosed incidentally on imaging or at laparotomy and has been mistakenly attributed to various malignancies and pathological conditions. On the rare occasion when splenosis plays a causative role in a pathological condition, a diagnostic challenge may ensue that can lead to a delay in both diagnosis and treatment. The following case report describes a patient presenting with a massive upper gastrointestinal bleed resulting from arterial enlargement within the gastric fundus secondary to perigastric splenosis...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27703389/ineffective-esophageal-motility-and-the-vagus-current-challenges-and-future-prospects
#8
Ji-Hong Chen
Ineffective esophageal motility (IEM) is characterized by low to very low amplitude propulsive contractions in the distal esophagus, hence primarily affecting the smooth muscle part of the esophagus. IEM is often found in patients with dysphagia or heartburn and is commonly associated with gastroesophageal reflux disease. IEM is assumed to be associated with ineffective bolus transport; however, this can be verified using impedance measurements or evaluation of a barium coated marshmallow swallow. Furthermore, water swallows may not assess accurately the motor capabilities of the esophagus, since contraction amplitude is strongly determined by the size and consistency of the bolus...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27695356/managing-eosinophilic-esophagitis-challenges-and-solutions
#9
Nisha A Shah, Dustin M Albert, Noah M Hall, Fouad J Moawad
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated condition defined by symptoms of esophageal dysfunction and dense eosinophilic infiltration of the esophageal mucosa. Therapies consist of anti-eosinophilic medications and specialized diets aimed to decrease the progression of EoE and alleviate its symptoms, namely, dysphagia and food impaction. Assessing response to therapy remains challenging, as treatment end points are not well defined and currently consist of clinical, histologic, and endoscopic features...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27695355/influence-of-saccharomyces-boulardii-cncm-i-745on-the-gut-associated-immune-system
#10
Heike Stier, Stephan C Bischoff
BACKGROUND: The probiotic Saccharomyces boulardii CNCM I-745 (also known as Saccharomyces cerevisiae HANSEN CBS 5926; in the following S. boulardii) has proven its effectiveness in preventive and therapeutic treatment of many gastrointestinal diseases, especially diseases associated with acute diarrhea. In particular, antibiotic-associated diarrhea, Clostridium difficile-associated diarrhea, traveller's diarrhea, as well as acute diarrhea due to common viral and bacterial infections in children and adults...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27601930/self-management-in-patients-with-inflammatory-bowel-disease-strategies-outcomes-and-integration-into-clinical-care
#11
REVIEW
Jill M Plevinsky, Rachel N Greenley, Laurie N Fishman
Self-management, including medication adherence, is associated with improved health and outcomes for patients with inflammatory bowel disease. The concept of self-management is complex, but can be divided into those aspects that involve the individual patient, those that involve the provider-patient relationship, and those that encompass the social environment. At the individual level, enhancing problem-solving skills and self-efficacy have both been shown to improve self-management tasks, particularly adherence to treatment...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27574459/acute-left-sided-colonic-diverticulitis-clinical-expressions-therapeutic-insights-and-role-of-computed-tomography
#12
REVIEW
Patrick Ambrosetti
The diagnostic approach of patients with suspected acute diverticulitis remains debated. On the one hand, a scoring system with the best predictive value in diagnosing acute diverticulitis has been developed in order to reduce the use of computed tomography (CT) scan, while, on the other hand, patients with a high probability of acute diverticulitis should benefit from CT scan from a clinical viewpoint, ensuring that they will receive the most appropriate treatment. The place and classification of CT scan for acute diverticulitis need to be reassessed...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27555793/hereditary-pancreatitis-current-perspectives
#13
REVIEW
Kara L Raphael, Field F Willingham
Hereditary pancreatitis (HP) is a rare cause of acute, recurrent acute, and chronic pancreatitis. It may present similarly to other causes of acute and chronic pancreatitis, and often there has been a protracted evaluation prior to the diagnosis of HP. Since it was first described in 1952, multiple genetic defects that affect the action of digestive enzymes in the pancreas have been implicated. The most common mutations involve the PRSS1, CFTR, SPINK1, and CTRC genes. New mutations in these genes and previously unrecognized mutations in other genes are being discovered due to the increasing use of next-generation genomic sequencing...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27555792/translational-and-clinical-perspectives-on-sphincter-of-oddi-dysfunction
#14
REVIEW
Kondal Rao Kyanam Kabir Baig, Charles Melbern Wilcox
Sphincter of Oddi dysfunction is a complex pathophysiologic entity that is associated with significant morbidity causing abdominal pain, nausea, and vomiting. The purpose of this review is to describe the anatomy and physiology of the sphincter of Oddi, to understand the pathologic mechanisms thought to be responsible for symptomatology, review recent major studies, explore endoscopic and pharmacologic therapies and their efficacy, and to explore future research avenues.
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27540307/optimal-delivery-of-follow-up-care-after-surgery-for-crohn-s-disease-current-perspectives
#15
REVIEW
James P Campbell, Byron P Vaughn
Despite improvements in medical therapies for Crohn's disease (CD), up to 70% of patients require surgery within 10 years of diagnosis. Surgery is not curative, and almost all patients will experience endoscopic recurrence, and many will go on to clinical recurrence. Identifying patients at high-risk of endoscopic recurrence and standardizing postoperative assessments are essential in preventing clinical recurrence of CD. In this review, we discuss the assessment, monitoring, and treatment of postoperative CD patients...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27536154/improving-outcomes-of-refractory-celiac-disease-current-and-emerging-treatment-strategies
#16
REVIEW
Jeremy Woodward
Intestinal inflammation and symptoms of celiac disease (CD) usually respond well to gluten withdrawal, but rare cases are refractory to diet. Two types of refractory CD are discriminated on the basis of the presence or absence of an atypical population of mucosal lymphocytes that may progress to enteropathy-associated T-cell lymphoma. Challenges remain in the secure diagnosis of both types of refractory disease, and evidence on which to base treatment recommendations is flawed by the small numbers of reported patients and the use of different diagnostic strategies...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27536153/an-update-on-antibody-based-immunotherapies-for-clostridium-difficile-infection
#17
REVIEW
Greg Hussack, Jamshid Tanha
Clostridium difficile continues to be one of the most prevalent hospital-acquired bacterial infections in the developed world, despite the recent introduction of a novel and effective antibiotic agent (fidaxomicin). Alternative approaches under investigation to combat the anaerobic Gram-positive bacteria include fecal transplantation therapy, vaccines, and antibody-based immunotherapies. In this review, we catalog the recent advances in antibody-based approaches under development and in the clinic for the treatment of C...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27524917/how-do-patients-clinical-phenotype-and-the-physiological-mechanisms-of-the-operations-impact-the-choice-of-bariatric-procedure
#18
REVIEW
Thomas Bächler, Carel W le Roux, Marco Bueter
Bariatric surgery is currently the most effective option for the treatment of morbid obesity and its associated comorbidities. Recent clinical and experimental findings have challenged the role of mechanical restriction and caloric malabsorption as the main mechanisms for weight loss and health benefits. Instead, other mechanisms including increased levels of satiety gut hormones, altered gut microbiota, changes in bile acid metabolism, and/or energy expenditure have been proposed as explanations for benefits of bariatric surgery...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27486340/safety-of-polyethylene-glycol-3350-solution-in-chronic-constipation-randomized-placebo-controlled-trial
#19
Thomas McGraw
PURPOSE: To evaluate the safety and tolerability of aqueous solution concentrate (ASC) of polyethylene glycol (PEG) 3350 in patients with functional constipation. PATIENTS AND METHODS: The patients who met Rome III diagnostic criteria for functional constipation were randomized in this multicenter, randomized, placebo-controlled, single-blind study to receive once daily dose of PEG 3350 (17 g) ASC or placebo solution for 14 days. The study comprised a screening period (visit 1), endoscopy procedure (visits 2 and 3), and followup telephone calls 30 days post-treatment...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27471402/proton-pump-inhibitors-for-the-treatment-of-patients-with-erosive-esophagitis-and-gastroesophageal-reflux-disease-current-evidence-and-safety-of-dexlansoprazole
#20
REVIEW
Joseph Mermelstein, Alanna Chait Mermelstein, Maxwell M Chait
Gastroesophageal reflux disease is the most common upper gastroenterology disorder in the US. It is associated with a variety of complications and significantly impacts quality of life. Proton pump inhibitors are the most effective treatment. Dexlansoprazole modified release (MR) is a proton pump inhibitor that employs a novel release formulation that prolongs its absorption and allows for more flexibility in dosing. Dexlansoprazole MR can be dosed without regard to food intake or time of day, and once-daily dosing may replace twice-daily dosing of other agents...
2016: Clinical and Experimental Gastroenterology
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