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World Journal of Gastrointestinal Oncology

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https://www.readbyqxmd.com/read/30364886/prognostic-value-of-vascular-endothelial-growth-factor-receptor-1-and-class-iii-%C3%AE-tubulin-in-survival-for-non-metastatic-rectal-cancer
#1
Xiang-Quan Kong, Yun-Xia Huang, Jin-Luan Li, Xue-Qing Zhang, Qing-Qin Peng, Li-Rui Tang, Jun-Xin Wu
AIM: To assess the long-term prognostic value of vascular endothelial growth factor receptor 1 (VEGFR1) and class III β-tubulin (TUBB3) mRNA expression in non-metastatic rectal cancer. METHODS: A total of 75 consecutive patients with non-metastatic rectal cancer from March 2004 to November 2008 were analyzed retrospectively at our institute. The mRNA expressions of VEGFR1 and TUBB3 were detected by multiplex branched DNA liquid-chip technology. The Cutoff Finder application was applied to determine cutoff point of mRNA expression...
October 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30364858/-mir-122-5p-as-a-novel-biomarker-for-alpha-fetoprotein-producing-gastric-cancer
#2
Suguru Maruyama, Shinji Furuya, Kensuke Shiraishi, Hiroki Shimizu, Hidenori Akaike, Naohiro Hosomura, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Makoto Sudo, Shingo Inoue, Hiroshi Kono, Daisuke Ichikawa
AIM: To investigate the clinical utility of alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC)-specific microRNA (miRNA) for monitoring and prognostic prediction of patients. METHODS: We performed a comprehensive miRNA array-based approach to compare miRNA expression levels between AFP-positive and AFP-negative cells in three patients with primary AFPGC. We next examined the expression levels of the selected miRNAs in five AFPGC and ten non-AFPGC tissue samples by quantitative reverse transcription-polymerase chain reaction to validate their utility...
October 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30364839/inhibiting-focal-adhesion-kinase-a-potential-target-for-enhancing-therapeutic-efficacy-in-colorectal-cancer-therapy
#3
EDITORIAL
Keun-Yeong Jeong
Focal adhesion kinase (FAK) is a major integrin-dependent tyrosine phosphorylated protein, recently, FAK association with colorectal cancer (CRC) has gained attention. The various cancer-promoting mechanisms that associated with FAK can be implicated in the progression of CRC. The interactions between structural features of FAK and various kinases could be closely related to growth, survival, and metastasis in CRC cells. These interactions include human epithelial growth factor receptor, c-Met, platelet-derived growth factor receptor, vascular endothelial growth factor receptor, and Src...
October 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30364837/histo-molecular-oncogenesis-of-pancreatic-cancer-from-precancerous-lesions-to-invasive-ductal-adenocarcinoma
#4
REVIEW
Giulio Riva, Antonio Pea, Camilla Pilati, Giulia Fiadone, Rita Teresa Lawlor, Aldo Scarpa, Claudio Luchini
Pancreatic cancer is a lethal malignancy, whose precursor lesions are pancreatic intraepithelial neoplasm, intraductal papillary mucinous neoplasm, intraductal tubulopapillary neoplasm, and mucinous cystic neoplasm. To better understand the biology of pancreatic cancer, it is fundamental to know its precursors and to study the mechanisms of carcinogenesis. Each of these precursors displays peculiar histological features, as well as specific molecular alterations. Starting from such pre-invasive lesions, this review aims at summarizing the most important aspects of carcinogenesis of pancreatic cancer, with a specific focus on the recent advances and the future perspectives of the research on this lethal tumor type...
October 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30364796/role-of-pre-transplant-18f-fdg-pet-ct-in-predicting-hepatocellular-carcinoma-recurrence-after-liver-transplantation
#5
REVIEW
Onur Yaprak, Sencan Acar, Gokhan Ertugrul, Murat Dayangac
The last two decades have seen a paradigm shift in the selection of patients with hepatocellular carcinoma (HCC) for liver transplantation. Microvascular invasion and differentiation have been the most significant factors affecting post-transplant recurrence; however, because of inherent disadvantages of pre-transplant biopsy, histological criteria never gained popularity. Recently, the selection criteria evolved from morphological to biological criteria, such as biomarkers and response to loco-regional therapy...
October 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30364780/optimizing-outcomes-for-patients-with-gastric-cancer-peritoneal-carcinomatosis
#6
EDITORIAL
Jennifer L Leiting, Travis E Grotz
Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival outcomes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limited. Recent advances in multimodality treatment regimens have led to innovative ways to care for and treat patients with this disease burden. One of these advances has been to use neoadjuvant therapy to try and convert patients with positive cytology or low-volume PC to negative cytology with no evidence of active peritoneal disease...
October 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30364774/simultaneous-curative-resection-of-double-colorectal-carcinoma-with-synchronous-bilobar-liver-metastases
#7
REVIEW
Emilio De Raffele, Mariateresa Mirarchi, Dajana Cuicchi, Ferdinando Lecce, Claudio Ricci, Riccardo Casadei, Bruno Cola, Francesco Minni
Synchronous colorectal carcinoma (SCRC) indicates more than one primary colorectal carcinoma (CRC) discovered at the time of initial presentation, accounts for 3.1%-3.9% of CRC, and may occur either in the same or in different colorectal segments. The accurate preoperative diagnosis of SCRC is difficult and diagnostic failures may lead to inappropriate treatment and poorer prognosis. SCRC requires colorectal resections tailored to individual patients, based on the number, location, and stage of the tumours, from conventional or extended hemicolectomies to total colectomy or proctocolectomy, when established predisposing conditions exist...
October 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30364712/predictive-factors-for-lymph-node-metastasis-and-defining-a-subgroup-treatable-for-laparoscopic-lymph-node-dissection-after-endoscopic-submucosal-dissection-in-poorly-differentiated-early-gastric-cancer
#8
Hua Li, Zhi-Bin Huo, Fan-Ting Kong, Qing-Qiang He, Yun-He Gao, Wen-Quan Liang, Deng-Xiang Liu
AIM: To investigate the predictive factors of lymph node metastasis (LNM) in poorly differentiated early gastric cancer (EGC); to guide the individual application of a combination of endoscopic submucosal dissection (ESD) and laparoscopic lymph node dissection (LLND) in a suitable subgroup of patients with poorly differentiated EGC. METHODS: We retrospectively analyzed 138 patients with poorly differentiated EGC who underwent gastrectomy with lymphadenectomy between January 1990 and December 2015...
October 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30364706/facing-the-challenge-of-venous-thromboembolism-prevention-in-patients-undergoing-major-abdominal-surgical-procedures-for-gastrointestinal-cancer
#9
REVIEW
Aikaterini Mastoraki, Sotiria Mastoraki, Dimitrios Schizas, Raphael Patras, Nikolaos Krinos, Ioannis S Papanikolaou, Andreas Lazaris, Theodore Liakakos, Nikolaos Arkadopoulos
Venous thromboembolism (VTE) refers to a hypercoagulable state that remains an important and preventable factor in the surgical treatment of malignancies. VTE includes two identical entities with regards to deep vein thrombosis and pulmonary embolism. The incidence of VTE after major abdominal interventions for gastro-intestinal, hepato-biliary and pancreatic neoplastic disorders is as high as 25% without prophylaxis. Prophylactic use of classic or low-molecular-weight heparin, anti-Xa factors, antithrombotic stocking, intermittent pneumatic compression devices and early mobilization have been described...
October 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30254722/between-evidence-and-new-perspectives-on-the-current-state-of-the-multimodal-approach-to-gastric-cancer-is-there-still-a-role-for-radiation-therapy
#10
REVIEW
Linda Agolli, Luca Nicosia
In patients affected by gastric cancer (GC), especially those in advanced stage, the multidisciplinary approach of treatment is fundamental to obtain a good disease control and quality of life. Although many chemotherapeutics in combination to radiotherapy are adopted in the peri- or postoperative setting, the most optimal timing, regimens and doses remains controversial. In the era of radical surgery performed with D2-lymphadenectomy, the role of radiation therapy remains to be better defined. Categories of patients, who could benefit more from an intensified local treatment rather than more toxic systemic therapy, are still under investigation...
September 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30254721/emerging-role-of-long-non-coding-rna-in-the-development-of-gastric-cancer
#11
REVIEW
Hang Yu, Long Rong
Gastric cancer is a common, worldwide malignancy and has a poor prognosis due to late diagnosis. Long non-coding RNAs (lncRNAs) are a significant subtype of RNA molecules with a length longer than 200 nucleotides (nt) that rarely encode proteins. In recent decades, deregulation of lncRNAs has been shown to be involved in tumorigenesis and tumor progression in various human carcinomas, including gastric cancer. Accumulating evidence has shown that some lncRNAs may function as diagnostic biomarkers or therapeutic targets for gastric cancer...
September 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30254720/colorectal-carcinogenesis-insights-into-the-cell-death-and-signal-transduction-pathways-a-review
#12
REVIEW
Ashok Kumar Pandurangan, Thomas Divya, Kalaivani Kumar, Vadivel Dineshbabu, Bakthavatchalam Velavan, Ganapasam Sudhandiran
Colorectal carcinogenesis (CRC) imposes a major health burden in developing countries. It is the third major cause of cancer deaths. Despite several treatment strategies, novel drugs are warranted to reduce the severity of this disease. Adenomatous polyps in the colon are the major culprits in CRC and found in 45% of cancers, especially in patients 60 years of age. Inflammatory polyps are currently gaining attention in CRC, and a growing body of evidence denotes the role of inflammation in CRC. Several experimental models are being employed to investigate CRC in animals, which include the APCmin/+ mouse model, Azoxymethane, Dimethyl hydrazine, and a combination of Dextran sodium sulphate and dimethyl hydrazine...
September 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30254719/priming-the-seed-helicobacter-pylori-alters-epithelial-cell-invasiveness-in-early-gastric-carcinogenesis
#13
REVIEW
Silvia Molina-Castro, Vanessa Ramírez-Mayorga, Warner Alpízar-Alpízar
Helicobacter pylori ( H. pylori ) infection is a well-established risk factor for the development of gastric cancer (GC), one of the most common and deadliest neoplasms worldwide. H. pylori infection induces chronic inflammation in the gastric mucosa that, in the absence of treatment, may progress through a series of steps to GC. GC is only one of several clinical outcomes associated with this bacterial infection, which may be at least partially attributed to the high genetic variability of H. pylori . The biological mechanisms underlying how and under what circumstances H...
September 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30254718/real-practice-studies-in-oncology-a-positive-perspective
#14
EDITORIAL
Alessandro Ottaiano
In the majority of phase III clinical trials, patients are generally excluded on the basis of specific comorbidities, performance status Eastern Cooperative Oncology Group ≥ 2, age ≥ 65 years, previous malignancies, brain metastases, active infections, psychiatric disorders, non-measurable disease, number and type of previous lines of chemotherapies or biologic therapies. A question is raised: Can results of phase IIIstudies be extended to the general population? There is increasing attention to and a resurgence of some terms as "real world" or "real practice" which are wrongly viewed as contrary to clinical trial protocols...
September 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30254717/immune-blockade-inhibitors-and-the-radiation-abscopal-effect-in-gastrointestinal-cancers
#15
EDITORIAL
Ioannis A Voutsadakis
The field of tumor immunology has produced in the recent years a revolution in cancer therapeutics putting an end in the long lasting frustration of investigators in the area stemming from largely unsuccessful strides to develop cancer vaccines. This progress has come from the introduction of immune checkpoint inhibitors, monoclonal antibodies blocking ligand/receptor pairs with inhibitory effects for immune cells. Through this blockade immune checkpoint blockers are able to activate the immune system and create an anti-tumoral effect...
September 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30147847/pancreatic-periampullary-and-biliary-cancer-with-liver-metastases-should-we-consider-resection-in-selected-cases
#16
Rachael Chang Lee, Harsh Kanhere, Markus Trochsler, Vy Broadbridge, Guy Maddern, Timothy J Price
AIM: To analyse the safety and efficacy of curative intent surgery in biliary and pancreatic cancer. METHODS: An extensive literature review was performed using MEDLINE, Google Scholar and EMBASE to identify articles regarding hepato-pancreatoduodenectomy or resection of liver metastasis in patients with pancreatic, biliary tract, periampullary and gallbladder cancers. RESULTS: A total of 19 studies were identified and reviewed. Major hepatectomy was undertaken in 391 patients...
August 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30147846/shattering-the-castle-walls-anti-stromal-therapy-for-pancreatic-cancer
#17
REVIEW
Ozkan Kanat, Hulya Ertas
Despite the availability of potent chemotherapy regimens, such as 5-fluorouracil, folinic acid, irinotecan, and oxaliplatin (FOLFIRINOX) and nab-paclitaxel plus gemcitabine, treatment outcomes in metastatic pancreatic cancer (PC) remain unsatisfactory. The presence of an abundant fibrous stroma in PC is considered a crucial factor for its unfavorable condition. Apparently, stroma acts as a physical barrier to restrict intratumoral cytotoxic drug penetration and creates a hypoxic environment that reduces the efficacy of radiotherapy...
August 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30079145/atypical-anastomotic-malignancies-of-small-bowel-after-subtotal-gastrectomy-with-billorth-ii-gastroenterostomy-for-peptic-ulcer-report-of-three-cases-and-review-of-the-literature
#18
Efstathios Kotidis, Orestis Ioannidis, Manousos George Pramateftakis, Konstantinos Christou, Ioannis Kanellos, Konstantinos Tsalis
AIM: To present patients who developed small-bowel malignancy at the level of the gastrointestinal anastomosis decades after a subtotal gastrectomy for ulcer, to review relevant literature, and to attempt to interpret the reasons those cancers developed to these postsurgical non-gastric sights. METHODS: For the current retrospective study and review of literature, the surgical and histopathological records dated from January 1, 1993 to December 31, 2017 of our department were examined, searching for patients who have undergone surgical treatment of small-bowel malignancy to identify those who have undergone subtotal gastrectomy for benign peptic ulcer...
July 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30079144/prediction-of-malignancy-and-adverse-outcome-of-solid-pseudopapillary-tumor-of-the-pancreas
#19
REVIEW
Li You, Feng Yang, De-Liang Fu
Since solid pseudopapillary tumor of the pancreas (SPTP) was officially classified by the World Health Organization in 1996, SPTP has recently received special attention in the literature. Studies have shown that SPTP is a heterogeneous tumor, with a small percentage of patients harboring aggressive behaviors. However, criteria for malignancy grade in SPTP have not been well established. The prognosis of SPTP is generally good, with cases having a chance for long-term survival even with recurrence and/or metastasis after surgical resection...
July 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30079143/advances-in-molecular-genetic-and-immune-signatures-of-gastric-cancer-are-we-ready-to-apply-them-in-our-patients-decision-making
#20
REVIEW
Stavros Gkolfinopoulos, Demetris Papamichael, Konstantinos Papadimitriou, Panos Papanastasopoulos, Vassilios Vassiliou, Panteleimon Kountourakis
In the last few years we have witnessed a vast expansion of our knowledge regarding the molecular and genetic profile of gastric cancer. The molecular subtypes described have shed light on the pathogenesis of the disease, thus prompting the development of new therapeutic strategies and favoring a more individualized approach for treatment. Most of the clinical trials for so called targeted therapies could be considered, at best, partially successful. In addition, checkpoint inhibitors have recently been added to our armamentarium in later stages of the disease, and combinations with chemotherapy and targeted agents are currently under development...
July 15, 2018: World Journal of Gastrointestinal Oncology
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