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World Journal of Hepatology

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https://www.readbyqxmd.com/read/28596819/usefulness-of-the-mesh-score-in-a-european-hepatocellular-carcinoma-cohort
#1
Xavier Adhoute, Guillaume Pénaranda, Jean-Luc Raoul, Marc Bourlière
The Barcelona Clinic Liver Cancer classification is the most widely - used hepatocellular carcinoma (HCC) staging system because it is simple, precise and linked to a treatment algorithm based on randomized studies. But each group includes a broad spectrum of tumors, with limited therapeutic options, particularly for intermediate and advanced stages. Consequently, different additional scoring systems have been proposed to refine the prognosis and/or to improve the management. But until now, there is no consensus...
May 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28596818/trend-of-hepatocellular-carcinoma-incidence-after-bayesian-correction-for-misclassified-data-in-iranian-provinces
#2
Nastaran Hajizadeh, Ahmad Reza Baghestani, Mohamad Amin Pourhoseingholi, Sara Ashtari, Zeinab Fazeli, Mohsen Vahedi, Mohammad Reza Zali
AIM: To study the trend of hepatocellular carcinoma incidence after correcting the misclassification in registering cancer incidence across Iranian provinces in cancer registry data. METHODS: Incidence data of hepatocellular carcinoma were extracted from Iranian annual of national cancer registration reports 2004 to 2008. A Bayesian method was implemented to estimate the rate of misclassification in registering cancer incidence in neighboring province. A beta prior is considered for misclassification parameter...
May 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28596817/cardiovascular-assessment-in-liver-transplant-for-non-alcoholic-steatohepatitis-patients-what-we-do-what-we-should-do
#3
REVIEW
Yolanda Sanchez-Torrijos, Javier Ampuero, Manuel Romero-Gómez
Non-alcoholic fatty liver disease (NAFLD) is increasing considerably due to the current lifestyle, which means that it is becoming one of the main indications for liver transplantation. On the other hand, there is a strong association between NAFLD and cardiovascular disease. This has been evidenced in many studies revealing a higher presence of carotid plaques or carotid intima-media thickness, leading to cardiovascular events and, ultimately, mortality. According to the liver transplant guidelines, screening for heart disease in transplant candidates should be performed by electrocardiogram and transthoracic echocardiography while a stress echocardiogram should be reserved for those with more than two cardiovascular risk factors or greater than 50 years old...
May 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28596816/coffee-the-magical-bean-for-liver-diseases
#4
REVIEW
Ryan D Heath, Mihir Brahmbhatt, Asli C Tahan, Jamal A Ibdah, Veysel Tahan
Coffee has long been recognized as having hepatoprotective properties, however, the extent of any beneficial effect is still being elucidated. Coffee appears to reduce risk of hepatocellular carcinoma, reduce advancement of fibrotic disease in a variety of chronic liver diseases, and perhaps reduce ability of hepatitis C virus to replicate. This review aims to catalog the evidence for coffee as universally beneficial across a spectrum of chronic liver diseases, as well as spotlight opportunities for future investigation into coffee and liver disease...
May 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28588752/inducible-protein-10-as-a-predictive-marker-of-antiviral-hepatitis-c-treatment-a-systematic-review
#5
REVIEW
Bastian Neesgaard, Morten Ruhwald, Nina Weis
AIM: To investigate interferon-γ-inducible protein-10's (IP-10) potential to anticipate rapid (RVR)- and sustained virological responses (SVR) to chronic hepatitis C (CHC) treatment. METHODS: We included case series examining RVR or SVR in relation to 24 or 48 wk treatment for CHC, in patients treatment free for at least six months, with genotype 1 or 4, and in relation to 24 wk treatment for genotype 2 and 3, with pegylated interferon in combination with ribavirin...
May 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28588751/protein-tolerance-to-standard-and-high-protein-meals-in-patients-with-liver-cirrhosis
#6
Octavio Campollo, Dirk Sprengers, Gitte Dam, Hendrik Vilstrup, Neil McIntyre
AIM: To investigate the plasma amino acid response and tolerance to normal or high protein meals in patients with cirrhosis. METHODS: The plasma amino acid response to a 20 g mixed protein meal was compared in 8 biopsy-proven compensated cirrhotic patients and 6 healthy subjects. In addition the response to a high protein meal (1 g/kg body weight) was studied in 6 decompensated biopsy-proven cirrhotics in order to evaluate their protein tolerance and the likelihood of developing hepatic encephalopathy (HE) following a porto-caval shunt procedure...
May 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28588750/image-quality-and-diagnostic-performance-of-free-breathing-diffusion-weighted-imaging-for-hepatocellular-carcinoma
#7
Yukihisa Takayama, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Yasuhiro Ushijima, Nobuhiro Fujita, Ken Shirabe, Atsushi Takemura, Hiroshi Honda
AIM: To retrospectively evaluate the diagnostic performance of free-breathing diffusion-weighted imaging (FB-DWI) with modified imaging parameter settings for detecting hepatocellular carcinomas (HCCs). METHODS: Fifty-one patients at risk for HCC were scanned with both FB-DWI and respiratory-triggered DWI with the navigator echo respiratory-triggering technique (RT-DWI). Qualitatively, the sharpness of the liver contour, the image noise and the chemical shift artifacts on each DWI with b-values of 1000 s/mm(2) were independently evaluated by three radiologists using 4-point scoring...
May 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28588749/strategies-to-tackle-the-challenges-of-external-beam-radiotherapy-for-liver-tumors
#8
REVIEW
Michael I Lock, Jonathan Klein, Hans T Chung, Joseph M Herman, Edward Y Kim, William Small, Nina A Mayr, Simon S Lo
Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity. Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis. However, the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment, management of motion and appropriate selection of dose regimen. This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines...
May 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28539992/bi-directional-hepatic-hydrothorax
#9
Madhan Nellaiyappan, Anastasios Kapetanos
A 59-year-old male with alcoholic cirrhosis presented to our hospital with an acutely painful umbilical hernia, and 4 mo of exertional dyspnea. He was noted to be tachypneic and hypoxic. He had a massive right sided pleural effusion with leftward mediastinal shift and gross ascites, with a tense, fluid-filled, umbilical hernia. Emergent paracentesis with drain placement and a large volume thoracentesis were performed. Despite improvement in dyspnea and drainage of 15 L of ascitic fluid, the massive transudative pleural effusion remained largely unchanged...
May 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28539991/importance-of-surgical-margin-in-the-outcomes-of-hepatocholangiocarcinoma
#10
Ka Wing Ma, Kenneth Siu Ho Chok
AIM: To evaluate the significance of resection margin width in the management of hepatocholangiocarcinoma (HCC-CC). METHODS: Data of consecutive patients who underwent hepatectomy for hepatic malignancies in the period from 1995 to 2014 were reviewed. Patients with pathologically confirmed HCC-CC were included for analysis. Demographic, biochemical, operative and pathological data were analyzed against survival outcomes. RESULTS: Forty-two patients were included for analysis...
May 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28539990/management-of-centrally-located-hepatocellular-carcinoma-update-2016
#11
REVIEW
Wei-Bo Yu, Andrew Rao, Victor Vu, Lily Xu, Jian-Yu Rao, Jian-Xiong Wu
Centrally located hepatocellular carcinoma (HCC) is sited in the central part of the liver and adjacent to main hepatic vascular structures. This special location is associated with an increase in the difficulty of surgery, aggregation of the recurrence disease, and greater challenge in disease management. This review summarizes the evolution of our understanding for centrally located HCC and discusses the development of treatment strategies, surgical approaches and recurrence prevention methods. To improve patient survival, a multi-disciplinary modality is greatly needed throughout the whole treatment period...
May 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28539989/hepatic-complications-induced-by-immunosuppressants-and-biologics-in-inflammatory-bowel-disease
#12
REVIEW
My-Linh Tran-Minh, Paula Sousa, Marianne Maillet, Matthieu Allez, Jean-Marc Gornet
The incidence of inflammatory bowel diseases (IBD) is rising worldwide. The therapeutic options for IBD are expanding, and the number of drugs with new targets will rapidly increase in coming years. A rapid step-up approach with close monitoring of intestinal inflammation is extensively used. The fear of side effects represents one the most limiting factor of their use. Despite a widespread use for years, drug induced liver injury (DILI) management remains a challenging situation with Azathioprine and Methotrexate...
May 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28515846/passive-expansion-of-sub-maximally-dilated-transjugular-intrahepatic-portosystemic-shunts-and-assessment-of-clinical-outcomes
#13
Michael C Hsu, Charles N Weber, S William Stavropoulos, Timothy W Clark, Scott O Trerotola, Richard D Shlansky-Goldberg, Michael C Soulen, Gregory J Nadolski
AIM: To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts (TIPS) and compare outcomes with maximally dilated TIPS. METHODS: Polytetrafluoroethylene covered TIPS (Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm (mTIPS), while 43 patients who were at increased risk for hepatic encephalopathy (HE), based on clinical evaluation or low pre-TIPS portosystemic gradient (PSG), had 10 mm TIPS sub-maximally dilated to 8 mm (smTIPS)...
April 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28515845/diagnosis-of-morbid-obesity-may-not-impact-healthcare-utilization-for-orthotopic-liver-transplantation-a-propensity-matched-study
#14
Joshua R Peck, Nicholas Latchana, Anthony Michaels, Adam J Hanje, Alice Hinton, Elmahdi A Elkhammas, Sylvester M Black, Khalid Mumtaz
AIM: To study mortality, length of stay, and total charges in morbidly obese adults during index hospitalization for orthotopic liver transplantation. METHODS: The Nationwide Inpatient Sample was queried to obtain demographics, healthcare utilization, post orthotopic liver transplantation (OLT) complications, and short term outcomes of OLT performed from 2003 to 2011 (n = 46509). We divided patients into those with [body mass index (BMI) ≥ 40] and without (BMI < 40) morbid obesity...
April 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28515844/role-of-circulating-micrornas-in-liver-diseases
#15
REVIEW
Sven H Loosen, Florian Schueller, Christian Trautwein, Sanchari Roy, Christoph Roderburg
MicroRNAs (miRNAs) are small RNAs regulate gene expression by inhibiting the turnover of their target mRNAs. In the last years, it became apparent that miRNAs are released into the circulation and circulating miRNAs emerged as a new class of biomarkers for various diseases. In this review we summarize available data on the role of circulating miRNAs in the context of acute and chronic liver diseases including hepatocellular and cholangiocellular carcinoma. Data from animal models are compared to human data and current challenges in the field of miRNAs research are discussed...
April 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28515843/emerging-concepts-in-alcoholic-hepatitis
#16
REVIEW
Phoenix Fung, Nikolaos Pyrsopoulos
Severe alcoholic hepatitis is implicated as a costly, worldwide public health issue with high morbidity and mortality. The one-month survival for severe alcoholic hepatitis is low with mortality rates high as 30%-50%. Abstinence from alcohol is the recommended first-line treatment. Although corticosteroids remain as the current evidence based option for selected patients with discriminant function > 32, improvement of short-term survival rate may be the only benefit. Identification of individuals with risk factors for the development of severe alcoholic hepatitis may provide insight to the diverse clinical spectrum and prognosis of the disease...
April 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28469812/18-fluoro-deoxyglucose-uptake-in-inflammatory-hepatic-adenoma-a-case-report
#17
Willy Liu, Jean Delwaide, Noella Bletard, Philippe Delvenne, Paul Meunier, Roland Hustinx, Olivier Detry
Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose ((18)FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of (18)FDG and benign tumors do not usually behave in such a way. The authors report herein the case of a 38-year-old female patient with a past medical history of cervical intraepithelial neoplasia and pheochromocytoma, in whom a liver lesion had been detected with PET-CT. The tumor was laparoscopically resected and the diagnosis of inflammatory hepatic adenoma was confirmed...
April 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28469811/factors-associated-with-success-of-telaprevir-and-boceprevir-based-triple-therapy-for-hepatitis-c-virus-infection
#18
Kian Bichoupan, Neeta Tandon, Valerie Martel-Laferriere, Neal M Patel, David Sachs, Michel Ng, Emily A Schonfeld, Alexis Pappas, James Crismale, Alicia Stivala, Viktoriya Khaitova, Donald Gardenier, Michael Linderman, William Olson, Ponni V Perumalswami, Thomas D Schiano, Joseph A Odin, Lawrence U Liu, Douglas T Dieterich, Andrea D Branch
AIM: To evaluate new therapies for hepatitis C virus (HCV), data about real-world outcomes are needed. METHODS: Outcomes of 223 patients with genotype 1 HCV who started telaprevir- or boceprevir-based triple therapy (May 2011-March 2012) at the Mount Sinai Medical Center were analyzed. Human immunodeficiency virus-positive patients and patients who received a liver transplant were excluded. Factors associated with sustained virological response (SVR24) and relapse were analyzed by univariable and multivariable logistic regression as well as classification and regression trees...
April 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28469810/efficacy-and-safety-of-dual-therapy-with-daclatasvir-and-asunaprevir-in-elderly-patients
#19
Kazuo Tarao, Katsuaki Tanaka, Akito Nozaki, Akira Sato, Toshiya Ishii, Hirokazu Komatsu, Takaaki Ikeda, Tatsuji Komatsu, Shozo Matsushima, Kenji Oshige
AIM: To survey the efficacy and safety of dual therapy with daclatasvir and asunaprevir in the elderly hepatitis C virus (HCV) patients multicentricity. METHODS: Interferon-ineligible/intolerant patients and non-responders to previous pegylated-interferon/ribavirin therapy with chronic HCV genotype 1b infection were enrolled. Child B, C cirrhotic patients were excluded. Patients received oral direct acting antiviral treatment consisting of 60 mg daclatasvir once daily plus 200 mg asunaprevir twice daily for 24 wk...
April 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28469809/hepatocellular-carcinoma-in-non-alcoholic-steatohepatitis-current-knowledge-and-implications-for-management
#20
REVIEW
George Cholankeril, Ronak Patel, Sandeep Khurana, Sanjaya K Satapathy
With the prevalence of hepatitis C virus expected to decline, the proportion of hepatocellular carcinoma (HCC) related to non-alcoholic steatohepatitis (NASH) is anticipated to increase exponentially due to the growing epidemic of obesity and diabetes. The annual incidence rate of developing HCC in patients with NASH-related cirrhosis is not clearly understood with rates ranging from 2.6%-12.8%. While multiple new mechanisms have been implicated in the development of HCC in NASH; further prospective long-term studies are needed to validate these findings...
April 18, 2017: World Journal of Hepatology
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