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Protein & Cell

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https://www.readbyqxmd.com/read/28110372/zika-virus-in-the-testes-should-we-be-worried
#1
Gary Wong, Shihua Li, Lei Liu, Yingxia Liu, Yuhai Bi
No abstract text is available yet for this article.
January 21, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28110371/jilun-li-and-his-profound-impact-on-theoretical-and-applied-agricultural-microbiology
#2
Chengbo Rong, Yu Liu, Ying Wen
No abstract text is available yet for this article.
January 21, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28108952/transcriptional-regulators-dictate-innate-lymphoid-cell-fates
#3
REVIEW
Chao Zhong, Jinfang Zhu
Research on innate lymphoid cells (ILC) has recently been a fast paced topic of immunological research. As ILCs are able to produce signature Th cytokine, ILCs have garnered considerable attention and have been described to represent the innate counterpart of the CD4(+) T helper (Th) cells. The development and function of ILCs are precisely regulated by a network of crucial transcription factors, which are also involved in the development or differentiation of conventional natural killer (cNK) cells and T cells...
January 20, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28108951/physiological-links-of-circadian-clock-and-biological-clock-of-aging
#4
REVIEW
Fang Liu, Hung-Chun Chang
Circadian rhythms orchestrate biochemical and physiological processes in living organisms to respond the day/night cycle. In mammals, nearly all cells hold self-sustained circadian clocks meanwhile couple the intrinsic rhythms to systemic changes in a hierarchical manner. The suprachiasmatic nucleus (SCN) of the hypothalamus functions as the master pacemaker to initiate daily synchronization according to the photoperiod, in turn determines the phase of peripheral cellular clocks through a variety of signaling relays, including endocrine rhythms and metabolic cycles...
January 20, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28108950/t-cell-receptor-engineered-t-cells-for-cancer-treatment-current-status-and-future-directions
#5
REVIEW
Yu Ping, Chaojun Liu, Yi Zhang
T-cell receptor (TCR)-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several advanced forms of cancer. Work using TCR-engineered T cells began more than two decades ago, with numerous preclinical studies showing that such cells could mediate tumor lysis and eradication. The success of these trials provided the foundation for clinical trials, including recent clinical successes using TCR-engineered T cells to target New York esophageal squamous cell carcinoma (NY-ESO-1)...
January 20, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28108949/dr-jian-zhou-the-great-inventor-of-cervical-cancer-vaccine
#6
Kong-Nan Zhao, Lifang Zhang, Jia Qu
No abstract text is available yet for this article.
January 20, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28108948/erratum-to-autophagy-induction-by-sirt6-is-involved-in-oxidative-stress-induced-neuronal-damage
#7
Jiaxiang Shao, Xiao Yang, Tengyuan Liu, Tingting Zhang, Qian Reuben Xie, Weiliang Xia
No abstract text is available yet for this article.
January 20, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28102490/genome-engineering-of-stem-cell-organoids-for-disease-modeling
#8
REVIEW
Yingmin Sun, Qiurong Ding
Precision medicine emerges as a new approach that takes into account individual variability. Successful realization of precision medicine requires disease models that are able to incorporate personalized disease information and recapitulate disease development processes at the molecular, cellular and organ levels. With recent development in stem cell field, a variety of tissue organoids can be derived from patient specific pluripotent stem cells and adult stem cells. In combination with the state-of-the-art genome editing tools, organoids can be further engineered to mimic disease-relevant genetic and epigenetic status of a patient...
January 19, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28097631/force-dependent-calcium-signaling-and-its-pathway-of-human-neutrophils-on-p-selectin-in-flow
#9
Bing Huang, Yingchen Ling, Jiangguo Lin, Xin Du, Ying Fang, Jianhua Wu
P-selectin engagement of P-selectin glycoprotein ligand-1 (PSGL-1) causes circulating leukocytes to roll on and adhere to the vascular surface, and mediates intracellular calcium flux, a key but unclear event for subsequent arresting firmly at and migrating into the infection or injured tissue. Using a parallel plate flow chamber technique and intracellular calcium ion detector (Fluo-4 AM), the intracellular calcium flux of firmly adhered neutrophils on immobilized P-selectin in the absence of chemokines at various wall shear stresses was investigated here in real time by fluorescence microscopy...
January 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28084564/erratum-to-structural-and-functional-analyses-of-human-ddx41-dead-domain
#10
Yan Jiang, Yanping Zhu, Weicheng Qiu, Yong-Jun Liu, Genhong Cheng, Zhi-Jie Liu, Songying Ouyang
No abstract text is available yet for this article.
January 13, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28044278/understand-spiciness-mechanism-of-trpv1-channel-activation-by-capsaicin
#11
REVIEW
Fan Yang, Jie Zheng
Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin activates this channel has been under extensive investigation using a variety of experimental techniques including mutagenesis, patch-clamp recording, crystallography, cryo-electron microscopy, computational docking and molecular dynamic simulation. A framework of how capsaicin binds and activates TRPV1 has started to merge: capsaicin binds to a pocket formed by the channel's transmembrane segments, where it takes a "tail-up, head-down" configuration...
January 2, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28044277/electron-microscopy-studies-of-the-coronavirus-ribonucleoprotein-complex
#12
LETTER
Miao Gui, Xin Liu, Deyin Guo, Zhen Zhang, Chang-Cheng Yin, Yu Chen, Ye Xiang
No abstract text is available yet for this article.
January 2, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28032250/porcine-diazepam-binding-inhibitor-and-bovine-diazepam-binding-inhibitor-affect-morphine-antinociception-via-different-receptors
#13
LETTER
Yu-Zhen Chen, Xiao-Cun Li, Zhen-Quan Guo, Li Zhou, Zhuan Zhou, Song-Ping Liang, Cai-Hong Wu
No abstract text is available yet for this article.
December 28, 2016: Protein & Cell
https://www.readbyqxmd.com/read/28028657/pml-rara-mutations-confer-varying-arsenic-trioxide-resistance
#14
LETTER
Dong-Mei Bai, Xiao-Feng Zheng
No abstract text is available yet for this article.
December 27, 2016: Protein & Cell
https://www.readbyqxmd.com/read/28012024/targeted-disruption-of-noc4l-leads-to-preimplantation-embryonic-lethality-in-mice
#15
LETTER
Yongli Qin, Haifeng Li, Lina Jia, Jinghua Yan, George Fu Gao, Xiangdong Li
No abstract text is available yet for this article.
December 24, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27995448/functional-characterization-of-human-equilibrative-nucleoside-transporter-1
#16
Weiyun Huang, Xin Zeng, Yigong Shi, Minhao Liu
Equilibrative nucleoside transporters (ENTs), which facilitate cross-membrane transport of nucleosides and nucleoside-derived drugs, play an important role in the salvage pathways of nucleotide synthesis, cancer chemotherapy, and treatment for virus infections. Functional characterization of ENTs at the molecular level remains technically challenging and hence scant. In this study, we report successful purification and biochemical characterization of human equilibrative nucleoside transporter 1 (hENT1) in vitro...
December 19, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27928732/structural-and-functional-analyses-of-human-ddx41-dead-domain
#17
LETTER
Yan Jiang, Yanping Zhu, Weicheng Qiu, Yong-Jun Liu, Genhong Cheng, Zhi-Jie Liu, Songying Ouyang
No abstract text is available yet for this article.
December 7, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27913985/erratum-to-questions-about-ngago
#18
Shawn Burgess, Linzhao Cheng, Feng Gu, Junjiu Huang, Zhiwei Huang, Shuo Lin, Jinsong Li, Wei Li, Wei Qin, Yujie Sun, Zhou Songyang, Wensheng Wei, Qiang Wu, Haoyi Wang, Xiaoqun Wang, Jing-Wei Xiong, Jianzhong Xi, Hui Yang, Bin Zhou, Bo Zhang
No abstract text is available yet for this article.
December 2, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27909985/il-25-blockade-inhibits-metastasis-in-breast-cancer
#19
Zhujun Jiang, Jingtao Chen, Xuemei Du, Hang Cheng, Xiaohu Wang, Chen Dong
Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metastasis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV-PyMT, a highly malignant spontaneous breast tumor model, IL-25 (also called IL-17E) was expressed by tumor-infiltrating CD4(+) T cells and macrophages. An IL-25 neutralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macrophages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subsequent metastasis to the lung...
December 1, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27909984/prof-shuch%C3%A3-n-teng-a-paragon-taxonomist-of-great-passion-and-firm-belief
#20
Guojie Li
No abstract text is available yet for this article.
December 1, 2016: Protein & Cell
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