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Protein & Cell

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https://www.readbyqxmd.com/read/28316032/old-master-zhu-in-memory-of-virologist-guan-fu-zhu
#1
Qing Ye, Tao Jiang, Cheng-Feng Qin
No abstract text is available yet for this article.
March 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28315159/identification-of-critical-base-pairs-required-for-ctcf-binding-in-motif-m1-and-m2
#2
LETTER
Wufeng Li, Liping Shang, Kaimeng Huang, Jiao Li, Zhibin Wang, Hongjie Yao
No abstract text is available yet for this article.
March 17, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28290053/targeting-cancer-stem-cells-by-using-chimeric-antigen-receptor-modified-t-cells-a-potential-and-curable-approach-for-cancer-treatment
#3
REVIEW
Yelei Guo, Kaichao Feng, Yao Wang, Weidong Han
Cancer stem cells (CSCs), a subpopulation of tumor cells, have self-renewal and multi-lineage differentiation abilities that play an important role in cancer initiation, maintenance, and metastasis. An accumulation of evidence indicates that CSCs can cause conventional therapy failure and cancer recurrence because of their treatment resistance and self-regeneration characteristics. Therefore, approaches that specifically and efficiently eliminate CSCs to achieve a durable clinical response are urgently needed...
March 13, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28290052/genome-wide-in-vivo-screen-identifies-host-molecule-in-promoting-cancer-metastasis
#4
Yan Gu, Yanfang Liu, Xuetao Cao
No abstract text is available yet for this article.
March 13, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28284008/effective-and-persistent-antitumor-activity-of-her2-directed-car-t-cells-against-gastric-cancer-cells-in-vitro-and-xenotransplanted-tumors-in-vivo
#5
Yanjing Song, Chuan Tong, Yao Wang, Yunhe Gao, Hanren Dai, Yelei Guo, Xudong Zhao, Yi Wang, Zizheng Wang, Weidong Han, Lin Chen
Human epidermal growth factor receptor 2 (HER2) proteins are overexpressed in a high proportion of gastric cancer (GC) cases and affect the maintenance of cancer stem cell (CSC) subpopulations, which are used as targets for the clinical treatment of patients with HER2-positive GC. Despite improvements in survival, numerous HER2-positive patients fail treatment with trastuzumab, highlighting the need for more effective therapies. In this study, we generated a novel type of genetically modified human T cells, expressing a chimeric antigen receptor (CAR), and targeting the GC cell antigen HER2, which harbors the CD137 and CD3ΞΆ moieties...
March 10, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28284007/erratum-to-protein-protein-interaction-analysis-in-crude-bacterial-lysates-using-combinational-method-of-19-f-site-specific-incorporation-and-19-f-nmr
#6
Dong Li, Yanan Zhang, Yao He, Chengwei Zhang, Jiefei Wang, Ying Xiong, Longhua Zhang, Yangzhong Liu, Pan Shi, Changlin Tian
No abstract text is available yet for this article.
March 10, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28284006/erratum-to-highly-efficient-generation-of-biallelic-reporter-gene-knock-in-mice-via-crispr-mediated-genome-editing-of-escs
#7
Yanliang Wang, Junhong Li, Jinzhu Xiang, Bingqiang Wen, Haiyuan Mu, Wei Zhang, Jianyong Han
No abstract text is available yet for this article.
March 10, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28271447/guards-at-the-gate-physiological-and-pathological-roles-of-tissue-resident-innate-lymphoid-cells-in-the-lung
#8
REVIEW
Hang Cheng, Chengyan Jin, Jing Wu, Shan Zhu, Yong-Jun Liu, Jingtao Chen
The lung is an important open organ and the primary site of respiration. Many life-threatening diseases develop in the lung, e.g., pneumonia, asthma, chronic obstructive pulmonary diseases (COPDs), pulmonary fibrosis, and lung cancer. In the lung, innate immunity serves as the frontline in both anti-irritant response and anti-tumor defense and is also critical for mucosal homeostasis; thus, it plays an important role in containing these pulmonary diseases. Innate lymphoid cells (ILCs), characterized by their strict tissue residence and distinct function in the mucosa, are attracting increased attention in innate immunity...
March 7, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28271446/in-vitro-engineered-non-antibody-protein-therapeutics
#9
REVIEW
Rudo Simeon, Zhilei Chen
Antibodies have proved to be a valuable mode of therapy for numerous diseases, mainly owing to their high target binding affinity and specificity. Unfortunately, antibodies are also limited in several respects, chief amongst those being the extremely high cost of manufacture. Therefore, non-antibody binding proteins have long been sought after as alternative therapies. New binding protein scaffolds are constantly being designed or discovered with some already approved for human use by the FDA. This review focuses on protein scaffolds that are either already being used in humans or are currently being evaluated in clinical trials...
March 7, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28271445/establishment-and-function-of-tissue-resident-innate-lymphoid-cells-in-the-skin
#10
REVIEW
Jie Yang, Luming Zhao, Ming Xu, Na Xiong
Innate lymphoid cells (ILCs) are a newly classified family of immune cells of the lymphoid lineage. While they could be found in both lymphoid organs and non-lymphoid tissues, ILCs are preferentially enriched in barrier tissues such as the skin, intestine, and lung where they could play important roles in maintenance of tissue integrity and function and protection against assaults of foreign agents. On the other hand, dysregulated activation of ILCs could contribute to tissue inflammatory diseases. In spite of recent progress towards understanding roles of ILCs in the health and disease, mechanisms regulating specific establishment, activation, and function of ILCs in barrier tissues are still poorly understood...
March 7, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28271444/the-role-of-mitochondria-in-osteogenic-adipogenic-and-chondrogenic-differentiation-of-mesenchymal-stem-cells
#11
REVIEW
Qianqian Li, Zewen Gao, Ye Chen, Min-Xin Guan
Mesenchymal stem cells (MSCs) are progenitors of connective tissues, which have emerged as important tools for tissue engineering due to their differentiation potential along various cell types. In recent years, accumulating evidence has suggested that the regulation of mitochondria dynamics and function is essential for successful differentiation of MSCs. In this paper, we review and provide an integrated view on the role of mitochondria in MSC differentiation. The mitochondria are maintained at a relatively low activity level in MSCs, and upon induction, mtDNA copy number, protein levels of respiratory enzymes, the oxygen consumption rate, mRNA levels of mitochondrial biogenesis-associated genes, and intracellular ATP content are increased...
March 7, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28271443/structural-insights-into-glutathione-mediated-activation-of-the-master-regulator-prfa-in-listeria-monocytogenes
#12
LETTER
Yong Wang, Han Feng, Yalan Zhu, Pu Gao
No abstract text is available yet for this article.
March 7, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28271442/weisun-tao-a-pioneer-of-biochemistry-in-china
#13
Tianwei He
No abstract text is available yet for this article.
March 7, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28258412/reversible-phosphorylation-of-the-26s-proteasome
#14
REVIEW
Xing Guo, Xiuliang Huang, Mark J Chen
The 26S proteasome at the center of the ubiquitin-proteasome system (UPS) is essential for virtually all cellular processes of eukaryotes. A common misconception about the proteasome is that, once made, it remains as a static and uniform complex with spontaneous and constitutive activity for protein degradation. Recent discoveries have provided compelling evidence to support the exact opposite insomuch as the 26S proteasome undergoes dynamic and reversible phosphorylation under a variety of physiopathological conditions...
March 3, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28251586/overexpression-of-hdac6-extends-reproductive-lifespan-in-mice
#15
LETTER
Xiaoxi Zhang, Jiao Yang, Haiying Wang, Renpeng Guo, Yu Yin, Dongdong Zhang, Qian Zhang, Hua Wang, Zhongcheng Zhou, Lingyi Chen, Jun Zhou, Lin Liu
No abstract text is available yet for this article.
March 1, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28233162/yu-tao-loo-and-the-development-of-neuropsychology-in-china
#16
Yanyan Qian, Wei Chen, Shengjun Wen
No abstract text is available yet for this article.
February 23, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28224292/dejun-yu-a-patriotic-botanist-and-his-contributions
#17
Hong Jiang
No abstract text is available yet for this article.
February 21, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28220393/common-and-distinct-regulation-of-human-and-mouse-brown-and-beige-adipose-tissues-a-promising-therapeutic-target-for-obesity
#18
REVIEW
Xuejiao Liu, Christopher Cervantes, Feng Liu
Obesity, which underlies various metabolic and cardiovascular diseases, is a growing public health challenge for which established therapies are inadequate. Given the current obesity epidemic, there is a pressing need for more novel therapeutic strategies that will help adult individuals to manage their weight. One promising therapeutic intervention for reducing obesity is to enhance energy expenditure. Investigations into human brown fat and the recently discovered beige/brite fat have galvanized intense research efforts during the past decade because of their pivotal roles in energy dissipation...
February 20, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28213719/the-life-and-work-of-dr-fan-qingsheng-a-pioneer-in-antibiotics-research-agricultural-microbiology-systems-agriculture-and-agricultural-education-in-china
#19
https://www.readbyqxmd.com/read/28213718/reprogramming-cell-fates-by-small-molecules
#20
REVIEW
Xiaojie Ma, Linghao Kong, Saiyong Zhu
Reprogramming cell fates towards pluripotent stem cells and other cell types has revolutionized our understanding of cellular plasticity. During the last decade, transcription factors and microRNAs have become powerful reprogramming factors for modulating cell fates. Recently, many efforts are focused on reprogramming cell fates by non-viral and non-integrating chemical approaches. Small molecules not only are useful in generating desired cell types in vitro for various applications, such as disease modeling and cell-based transplantation, but also hold great promise to be further developed as drugs to stimulate patients' endogenous cells to repair and regenerate in vivo...
February 17, 2017: Protein & Cell
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