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Protein & Cell

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https://www.readbyqxmd.com/read/28717989/the-carma3-bcl10-malt1-cbm-complex-contributes-to-dna-damage-induced-nf-%C3%AE%C2%BAb-activation-and-cell-survival
#1
LETTER
Shilei Zhang, Deng Pan, Xin-Ming Jia, Xin Lin, Xueqiang Zhao
No abstract text is available yet for this article.
July 17, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28710747/phase-i-study-of-chimeric-antigen-receptor-modified-t-cells-in-treating-her2-positive-advanced-biliary-tract-cancers-and-pancreatic-cancers
#2
Kaichao Feng, Yang Liu, Yelei Guo, Jingdan Qiu, Zhiqiang Wu, Hanren Dai, Qingming Yang, Yao Wang, Weidong Han
This phase I clinical trial (NCT01935843) is to evaluate the safety, feasibility, and activity of chimeric antigen receptor-engineered T cell (CART) immunotherapy targeting human epidermal growth factor receptor 2 (HER2) in patients with advanced biliary tract cancers (BTCs) and pancreatic cancers (PCs). Eligible patients with HER2-positive (>50%) BTCs and PCs were enrolled in the trial. Well cultured CART-HER2 cells were infused following the conditioning treatment composed of nab-paclitaxel (100-200 mg/m(2)) and cyclophosphamide (15-35 mg/kg)...
July 14, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28695470/screening-novel-stress-granule-regulators-from-a-natural-compound-library
#3
LETTER
Li-Dan Hu, Xiang-Jun Chen, Xiao-Yan Liao, Yong-Bin Yan
No abstract text is available yet for this article.
July 10, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28688083/the-swi-snf-chromatin-remodeling-factors-baf60a-b-and-c-in-nutrient-signaling-and-metabolic-control
#4
REVIEW
Ruo-Ran Wang, Ran Pan, Wenjing Zhang, Junfen Fu, Jiandie D Lin, Zhuo-Xian Meng
Metabolic syndrome has become a global epidemic that adversely affects human health. Both genetic and environmental factors contribute to the pathogenesis of metabolic disorders; however, the mechanisms that integrate these cues to regulate metabolic physiology and the development of metabolic disorders remain incompletely defined. Emerging evidence suggests that SWI/SNF chromatin-remodeling complexes are critical for directing metabolic reprogramming and adaptation in response to nutritional and other physiological signals...
July 7, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28677105/carboxylesterases-in-lipid-metabolism-from-mouse-to-human
#5
REVIEW
Jihong Lian, Randal Nelson, Richard Lehner
Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro through (over)expression, knockdown of expression, and chemical inhibition in a variety of cells. Recent research advances have revealed the relevance of carboxylesterases to metabolic diseases such as obesity and fatty liver disease, suggesting these enzymes might be potential targets for treatment of metabolic disorders...
July 4, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28677104/the-dark-side-of-browning
#6
REVIEW
Kirstin A Tamucci, Maria Namwanje, Lihong Fan, Li Qiang
The induction of brown-like adipocyte development in white adipose tissue (WAT) confers numerous metabolic benefits by decreasing adiposity and increasing energy expenditure. Therefore, WAT browning has gained considerable attention for its potential to reverse obesity and its associated co-morbidities. However, this perspective has been tainted by recent studies identifying the detrimental effects of inducing WAT browning. This review aims to highlight the adverse outcomes of both overactive and underactive browning activity, the harmful side effects of browning agents, as well as the molecular brake-switch system that has been proposed to regulate this process...
July 4, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28677103/a-novel-therapeutic-anti-hbv-antibody-with-increased-binding-to-human-fcrn-improves-in-vivo-pk-in-mice-and-monkeys
#7
LETTER
Ciming Kang, Lin Xia, Yuanzhi Chen, Tianying Zhang, Yiwen Wang, Bing Zhou, Min You, Quan Yuan, Chi-Meng Tzeng, Zhiqiang An, Wenxin Luo, Ningshao Xia
No abstract text is available yet for this article.
July 4, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28677102/cle42-binding-induces-pxl2-interaction-with-serk2
#8
LETTER
Shulin Mou, Xiaoxiao Zhang, Zhifu Han, Jiawei Wang, Xinqi Gong, Jijie Chai
No abstract text is available yet for this article.
July 4, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28664251/structure-of-unliganded-membrane-proximal-domains-fn4-fn5-fn6-of-dcc
#9
LETTER
Lorenzo I Finci, Jie Zhang, Xiaqin Sun, Robert G Smock, Rob Meijers, Yan Zhang, Junyu Xiao, Jia-Huai Wang
No abstract text is available yet for this article.
June 29, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28646361/erratum-to-chimeric-antigen-receptor-car-modified-natural-killer-cell-based-immunotherapy-and-immunological-synapse-formation-in-cancer-and-hiv
#10
Dongfang Liu, Shuo Tian, Kai Zhang, Wei Xiong, Ndongala Michel Lubaki, Zhiying Chen, Weidong Han
No abstract text is available yet for this article.
June 23, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28643267/new-insight-into-inter-organ-crosstalk-contributing-to-the-pathogenesis-of-non-alcoholic-fatty-liver-disease-nafld
#11
REVIEW
Xu Zhang, Xuetao Ji, Qian Wang, John Zhong Li
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver dysfunction and a significant global health problem with substantial rise in prevalence over the last decades. It is becoming increasingly clear that NALFD is not only predominantly a hepatic manifestation of metabolic syndrome, but also involves extra-hepatic organs and regulatory pathways. Therapeutic options are limited for the treatment of NAFLD. Accordingly, a better understanding of the pathogenesis of NAFLD is critical for gaining new insight into the regulatory network of NAFLD and for identifying new targets for the prevention and treatment of NAFLD...
June 22, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28597152/glycosylation-engineering-of-therapeutic-igg-antibodies-challenges-for-the-safety-functionality-and-efficacy
#12
REVIEW
Yusuke Mimura, Toshihiko Katoh, Radka Saldova, Roisin O'Flaherty, Tomonori Izumi, Yuka Mimura-Kimura, Toshiaki Utsunomiya, Yoichi Mizukami, Kenji Yamamoto, Tsuneo Matsumoto, Pauline M Rudd
Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex-type oligosaccharide attached to Asn297 of the Fc is essential for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that generate structural heterogeneity (glycoforms) exhibit unique biological activities. Hence, efficient and quantitative glycan analysis techniques have been increasingly important for the development and quality control of therapeutic antibodies, and glycan profiles of the Fc are recognized as critical quality attributes...
June 8, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28593618/rig-i-a-multifunctional-protein-beyond-a-pattern-recognition-receptor
#13
REVIEW
Xiao-Xiao Xu, Han Wan, Li Nie, Tong Shao, Li-Xin Xiang, Jian-Zhong Shao
It was widely known that retinoic acid inducible gene I (RIG-I) functions as a cytosolic pattern recognition receptor that initiates innate antiviral immunity by detecting exogenous viral RNAs. However, recent studies showed that RIG-I participates in other various cellular activities by sensing endogenous RNAs under different circumstances. For example, RIG-I facilitates the therapy resistance and expansion of breast cancer cells and promotes T cell-independent B cell activation through interferon signaling activation by recognizing non-coding RNAs and endogenous retroviruses in certain situations...
June 8, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28585179/effective-gene-editing-by-high-fidelity-base-editor-2-in-mouse-zygotes
#14
LETTER
Puping Liang, Hongwei Sun, Ying Sun, Xiya Zhang, Xiaowei Xie, Jinran Zhang, Zhen Zhang, Yuxi Chen, Chenhui Ding, Yuanyan Xiong, Wenbin Ma, Dan Liu, Junjiu Huang, Zhou Songyang
Targeted point mutagenesis through homologous recombination has been widely used in genetic studies and holds considerable promise for repairing disease-causing mutations in patients. However, problems such as mosaicism and low mutagenesis efficiency continue to pose challenges to clinical application of such approaches. Recently, a base editor (BE) system built on cytidine (C) deaminase and CRISPR/Cas9 technology was developed as an alternative method for targeted point mutagenesis in plant, yeast, and human cells...
June 5, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28585178/editing-base-in-mouse-model
#15
Haoyi Wang
No abstract text is available yet for this article.
June 5, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28585177/potent-and-conditional-redirected-t-cell-killing-of-tumor-cells-using-half-dvd-ig
#16
Philip D Bardwell, Matthew M Staron, Junjian Liu, Qingfeng Tao, Susanne Scesney, Gail Bukofzer, Luis E Rodriguez, Chee-Ho Choi, Jennifer Wang, Qing Chang, Feng Dong, Cherrie Donawho, Jieyi Wang, Christine M Grinnell, Edit Tarcsa, Charles Hutchins, Tariq Ghayur, Jijie Gu
Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens (TAA) expressed on tumor cells remains a challenge of both technology and biology. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each specificity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties...
June 5, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28585176/the-crystal-structure-of-ac-achbp-in-complex-with-%C3%AE-conotoxin-lvia-reveals-the-mechanism-of-its-selectivity-towards-different-nachr-subtypes
#17
Manyu Xu, Xiaopeng Zhu, Jinfang Yu, Jinpeng Yu, Sulan Luo, Xinquan Wang
The α3* nAChRs, which are considered to be promising drug targets for problems such as pain, addiction, cardiovascular function, cognitive disorders etc., are found throughout the central and peripheral nervous system. The α-conotoxin (α-CTx) LvIA has been identified as the most selective inhibitor of α3β2 nAChRs known to date, and it can distinguish the α3β2 nAChR subtype from the α6/α3β2β3 and α3β4 nAChR subtypes. However, the mechanism of its selectivity towards α3β2, α6/α3β2β3, and α3β4 nAChRs remains elusive...
June 5, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28555377/alphalisa-detection-of-alpha-synuclein-in-the-cerebrospinal-fluid-and-its-potential-application-in-parkinson-s-disease-diagnosis
#18
LETTER
Hongli Zhao, Jue Zhao, Jiapeng Hou, Siqing Wang, Yu Ding, Boxun Lu, Jian Wang
No abstract text is available yet for this article.
May 29, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28540654/a-110-year-old-wise-man-professor-libin-t-cheng-one-of-the-founders-of-biochemistry-and-nutrition-in-china
#19
He Zhang
No abstract text is available yet for this article.
May 24, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28540653/il-2-and-il-15-dependent-thymic-development-of-foxp3-expressing-regulatory-t-lymphocytes
#20
REVIEW
Cécile Apert, Paola Romagnoli, Joost P M van Meerwijk
Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 (IL-2) and IL-15...
May 24, 2017: Protein & Cell
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