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Protein & Cell

Zhekun Zhou
No abstract text is available yet for this article.
July 11, 2018: Protein & Cell
Guoxing Zheng, Changying Jiang, Yulin Li, Dandan Yang, Youcai Ma, Bing Zhang, Xuan Li, Pei Zhang, Xiaoyu Hu, Xueqiang Zhao, Jie Du, Xin Lin
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a genetic cardiac muscle disease that accounts for approximately 30% sudden cardiac death in young adults. The Ser358Leu mutation of transmembrane protein 43 (TMEM43) was commonly identified in the patients of highly lethal and fully penetrant ARVD subtype, ARVD5. Here, we generated TMEM43 S358L mouse to explore the underlying mechanism. This mouse strain showed the classic pathologies of ARVD patients, including structural abnormalities and cardiac fibrofatty...
July 6, 2018: Protein & Cell
Gaibian Wang, Quanxing Zhang, Yongping Yang
No abstract text is available yet for this article.
July 6, 2018: Protein & Cell
Ping Wang, Zunpeng Liu, Xiaoqian Zhang, Jingyi Li, Liang Sun, Zhenyu Ju, Jian Li, Piu Chan, Guang-Hui Liu, Weiqi Zhang, Moshi Song, Jing Qu
Vascular cell functionality is critical to blood vessel homeostasis. Constitutive NF-κB activation in vascular cells results in chronic vascular inflammation, leading to various cardiovascular diseases. However, how NF-κB regulates human blood vessel homeostasis remains largely elusive. Here, using CRISPR/Cas9-mediated gene editing, we generated RelA knockout human embryonic stem cells (hESCs) and differentiated them into various vascular cell derivatives to study how NF-κB modulates human vascular cells under basal and inflammatory conditions...
July 2, 2018: Protein & Cell
Dandan Luo, Weihong Ge, Xiao Hu, Chen Li, Chia-Ming Lee, Liqiang Zhou, Zhourui Wu, Juehua Yu, Sheng Lin, Jing Yu, Wei Xu, Lei Chen, Chong Zhang, Kun Jiang, Xingfei Zhu, Haotian Li, Xinpei Gao, Yanan Geng, Bo Jing, Zhen Wang, Changhong Zheng, Rongrong Zhu, Qiao Yan, Quan Lin, Keqiang Ye, Yi E Sun, Liming Cheng
The mammalian central nervous system (CNS) is considered an immune privileged system as it is separated from the periphery by the blood brain barrier (BBB). Yet, immune functions have been postulated to heavily influence the functional state of the CNS, especially after injury or during neurodegeneration. There is controversy regarding whether adaptive immune responses are beneficial or detrimental to CNS injury repair. In this study, we utilized immunocompromised SCID mice and subjected them to spinal cord injury (SCI)...
June 28, 2018: Protein & Cell
Qianlan Xu, Ruoyu Wang, A R Ghanam, Guanxiong Yan, Wei Miao, Xiaoyuan Song
In the original publication, the funding information was incorrectly published. The correct funding information is provided in this correction. This work is supported by grants from the Projects of International Cooperation and Exchanges Ministry of Science and Technology of China (2013DFG32390) and the National Natural Science Foundation of China (31472059) to X.S. X.S is a recipient of the Young Thousand Talents program (KJ2070000026).
June 27, 2018: Protein & Cell
Haibo Li, Chaoran Zhao, Jun Xu, Yaxing Xu, Chunmei Cheng, Yinan Liu, Ting Wang, Yaqin Du, Liangfu Xie, Jingru Zhao, Yanchuang Han, Xiaobao Wang, Yun Bai, Hongkui Deng
One major strategy to generate genetically modified mouse models is gene targeting in mouse embryonic stem (ES) cells, which is used to produce gene-targeted mice for wide applications in biomedicine. However, a major bottleneck in this approach is that the robustness of germline transmission of gene-targeted ES cells can be significantly reduced by their genetic and epigenetic instability after long-term culturing, which impairs the efficiency and robustness of mouse model generation. Recently, we have established a new type of pluripotent cells termed extended pluripotent stem (EPS) cells, which have superior developmental potency and robust germline competence compared to conventional mouse ES cells...
June 13, 2018: Protein & Cell
Yaqin Du, Ting Wang, Jun Xu, Chaoran Zhao, Haibo Li, Yao Fu, Yaxing Xu, Liangfu Xie, Jingru Zhao, Weifeng Yang, Ming Yin, Jinhua Wen, Hongkui Deng
Recently we have established a new culture condition enabling the derivation of extended pluripotent stem (EPS) cells, which, compared to conventional pluripotent stem cells, possess superior developmental potential and germline competence. However, it remains unclear whether this condition permits derivation of EPS cells from mouse strains that are refractory or non-permissive to pluripotent cell establishment. Here, we show that EPS cells can be robustly generated from non-permissive NOD-scid Il2rg-/- mice through de novo derivation from blastocysts...
June 13, 2018: Protein & Cell
Rui Liu
No abstract text is available yet for this article.
June 11, 2018: Protein & Cell
Yong Lin, Chunchen Wu, Xueyu Wang, Thekla Kemper, Anthony Squire, Matthias Gunzer, Jiming Zhang, Xinwen Chen, Mengji Lu
No abstract text is available yet for this article.
June 6, 2018: Protein & Cell
Wei Mu, Yongping Zhang, Xutong Xue, Lei Liu, Xiaofei Wei, Haoyi Wang
No abstract text is available yet for this article.
June 4, 2018: Protein & Cell
Xiang Zhang, Xiaoyu Li, Fei Ning, Yingli Shang, Xiaoyu Hu
No abstract text is available yet for this article.
June 4, 2018: Protein & Cell
Yue Shi, Zipeng Duan, Xun Zhang, Xiaotian Zhang, Guoqing Wang, Fan Li
No abstract text is available yet for this article.
June 1, 2018: Protein & Cell
Wei Chen, Xi Chen, Shengjun Wen
No abstract text is available yet for this article.
May 21, 2018: Protein & Cell
Xinyu Liu, Xin Zhao, Rui Na, Lili Li, Eberhard Warkentin, Jennifer Witt, Xu Lu, Yongxin Yu, Yuquan Wei, Guohong Peng, Yuhua Li, Junzhi Wang
No abstract text is available yet for this article.
May 11, 2018: Protein & Cell
Lu Gao, Tiansong Xu, Gang Huang, Song Jiang, Yan Gu, Feng Chen
Microbes appear in every corner of human life, and microbes affect every aspect of human life. The human oral cavity contains a number of different habitats. Synergy and interaction of variable oral microorganisms help human body against invasion of undesirable stimulation outside. However, imbalance of microbial flora contributes to oral diseases and systemic diseases. Oral microbiomes play an important role in the human microbial community and human health. The use of recently developed molecular methods has greatly expanded our knowledge of the composition and function of the oral microbiome in health and disease...
May 7, 2018: Protein & Cell
Lijuan Sun, Lanjing Ma, Yubo Ma, Faming Zhang, Changhai Zhao, Yongzhan Nie
No abstract text is available yet for this article.
May 3, 2018: Protein & Cell
Zeneng Wang, Yongzhong Zhao
Trillions of microbes inhabit the human gut, not only providing nutrients and energy to the host from the ingested food, but also producing metabolic bioactive signaling molecules to maintain health and elicit disease, such as cardiovascular disease (CVD). CVD is the leading cause of mortality worldwide. In this review, we presented gut microbiota derived metabolites involved in cardiovascular health and disease, including trimethylamine-N-oxide (TMAO), uremic toxins, short chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids and lipopolysaccharide...
May 3, 2018: Protein & Cell
Zhihua Liu
No abstract text is available yet for this article.
May 2, 2018: Protein & Cell
Yongquan Lin, Yan Wang, Hui Li, Yuhang Chen, Wentao Qiao, Zhi Xie, Juan Tan, Zhilong Yang
No abstract text is available yet for this article.
April 25, 2018: Protein & Cell
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