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Protein & Cell

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https://www.readbyqxmd.com/read/28913786/the-lipid-droplet-a-conserved-cellular-organelle
#1
REVIEW
Congyan Zhang, Pingsheng Liu
The lipid droplet (LD) is a unique multi-functional organelle that contains a neutral lipid core covered with a phospholipid monolayer membrane. The LDs have been found in almost all organisms from bacteria to humans with similar shape. Several conserved functions of LDs have been revealed by recent studies, including lipid metabolism and trafficking, as well as nucleic acid binding and protection. We summarized these findings and proposed a hypothesis that the LD is a conserved organelle.
September 14, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28884441/inhibition-of-retroviral-gag-assembly-by-non-silencing-mirnas-promotes-autophagic-viral-degradation
#2
Na Qu, Zhao Ma, Mengrao Zhang, Muaz N Rushdi, Christopher J Krueger, Antony K Chen
We recently reported an unconventional mechanism by which miRNAs inhibit HIV-1 viral production. This occurs when miRNAs bind nonspecifically to the viral structural protein Gag, interfering with viral RNA-mediated Gag assembly at the plasma membrane. Consequently, misassembled viral complexes are redirected into the endocytic pathway where they are delivered to lysosomes for degradation. In this study, we demonstrate that autophagy is a critical mediator of the viral degradation pathway and that this pathway is not HIV-1 specific...
September 7, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28875452/long-non-coding-rna-tagging-and-expression-manipulation-via-crispr-cas9-mediated-targeted-insertion
#3
LETTER
Tian-Lin Cheng, Zilong Qiu
No abstract text is available yet for this article.
September 5, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28875450/cryo-em-structure-of-mycobacterium-smegmatis-ribosome-reveals-two-unidentified-ribosomal-proteins-close-to-the-functional-centers
#4
LETTER
Zhifei Li, Xueliang Ge, Yixiao Zhang, Lvqin Zheng, Suparna Sanyal, Ning Gao
No abstract text is available yet for this article.
September 5, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28875424/structural-basis-for-daxx-interaction-with-atrx
#5
LETTER
Xiaoman Wang, Yiyue Zhao, Jian Zhang, Yong Chen
No abstract text is available yet for this article.
September 5, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28875305/highly-efficient-base-editing-in-human-tripronuclear-zygotes
#6
LETTER
Changyang Zhou, Meiling Zhang, Yu Wei, Yidi Sun, Yun Sun, Hong Pan, Ning Yao, Wanxia Zhong, Yixue Li, Weiping Li, Hui Yang, Zi-Jiang Chen
No abstract text is available yet for this article.
September 5, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28875283/structural-and-biochemical-characterization-of-daxx-atrx-interaction
#7
LETTER
Zhuang Li, Dan Zhao, Bin Xiang, Haitao Li
No abstract text is available yet for this article.
September 5, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28831681/neddylation-antagonizes-ubiquitination-of-proliferating-cell-nuclear-antigen-and-regulates-the-recruitment-of-polymerase-%C3%AE-in-response-to-oxidative-dna-damage
#8
Junhong Guan, Shuyu Yu, Xiaofeng Zheng
NEDDylation has been shown to participate in the DNA damage pathway, but the substrates of neural precursor cell expressed developmentally downregulated 8 (NEDD8) and the roles of NEDDylation involved in the DNA damage response (DDR) are largely unknown. Translesion synthesis (TLS) is a damage-tolerance mechanism, in which RAD18/RAD6-mediated monoubiquitinated proliferating cell nuclear antigen (PCNA) promotes recruitment of polymerase η (polη) to bypass lesions. Here we identify PCNA as a substrate of NEDD8, and show that E3 ligase RAD18-catalyzed PCNA NEDDylation antagonizes its ubiquitination...
August 22, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28828720/live-cell-imaging-of-genomic-loci-using-dcas9-suntag-system-and-a-bright-fluorescent-protein
#9
LETTER
Huiying Ye, Zhili Rong, Ying Lin
No abstract text is available yet for this article.
August 21, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28825190/highly-efficient-and-precise-base-editing-in-discarded-human-tripronuclear-embryos
#10
LETTER
Guanglei Li, Yajing Liu, Yanting Zeng, Jianan Li, Lijie Wang, Guang Yang, Dunjin Chen, Xiaoyun Shang, Jia Chen, Xingxu Huang, Jianqiao Liu
No abstract text is available yet for this article.
August 19, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28822114/glycosylation-of-dentin-matrix-protein-1-is-a-novel-key-element-for-astrocyte-maturation-and-bbb-integrity
#11
Bo Jing, Chunxue Zhang, Xianjun Liu, Liqiang Zhou, Jiping Liu, Yinan Yao, Juehua Yu, Yuteng Weng, Min Pan, Jie Liu, Zuolin Wang, Yao Sun, Yi Eve Sun
The blood-brain barrier (BBB) is a tight boundary formed between endothelial cells and astrocytes, which separates and protects brain from most pathogens as well as neural toxins in circulation. However, detailed molecular players involved in formation of BBB are not completely known. Dentin matrix protein 1 (DMP1)-proteoglycan (PG), which is known to be involved in mineralization of bones and dentin, is also expressed in soft tissues including brain with unknown functions. In the present study, we reported that DMP1-PG was expressed in brain astrocytes and enriched in BBB units...
August 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28822103/current-progress-in-innovative-engineered-antibodies
#12
REVIEW
William R Strohl
As of May 1, 2017, 74 antibody-based molecules have been approved by a regulatory authority in a major market. Additionally, there are 70 and 575 antibody-based molecules in phase III and phase I/II clinical trials, respectively. These total 719 antibody-based clinical stage molecules include 493 naked IgGs, 87 antibody-drug conjugates, 61 bispecific antibodies, 37 total Fc fusion proteins, 17 radioimmunoglobulins, 13 antibody fragments, and 11 immunocytokines. New uses for these antibodies are being discovered each year...
August 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28822100/using-a-novel-cellular-platform-to-optimize-crispr-cas9-technology-for-the-gene-therapy-of-aids
#13
LETTER
Jingjin He, Thanutra Zhang, Xuemei Fu
No abstract text is available yet for this article.
August 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28822092/zn-ii-can-mediate-self-association-of-the-extracellular-c-terminal-domain-of-cd147
#14
LETTER
Shujuan Jin, Pengfei Ding, Pengxiang Chu, Hongwei Li, Jianbo Sun, Dehai Liang, Fei Song, Bin Xia
No abstract text is available yet for this article.
August 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28766261/the-excessive-response-a-preparation-for-harder-conditions
#15
Yaguang Ren, Chao Zhang
No abstract text is available yet for this article.
August 1, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28755204/dr-chi-ming-chu-respected-founder-of-molecular-virology-and-pioneer-of-biologicals-in-china
#16
Weizheng Yan, Baoying Huang, Li Ruan, Wenjie Tan
No abstract text is available yet for this article.
July 28, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28755203/micrornas-recruit-eif4e2-to-repress-translation-of-target-mrnas
#17
Shaohong Chen, Guangxia Gao
MicroRNAs (miRNAs) recruit the RNA-induced silencing complex (RISC) to repress the translation of target mRNAs. While the 5' 7-methylguanosine cap of target mRNAs has been well known to be important for miRNA repression, the underlying mechanism is not clear. Here we show that TNRC6A interacts with eIF4E2, a homologue of eIF4E that can bind to the cap but cannot interact with eIF4G to initiate translation, to inhibit the translation of target mRNAs. Downregulation of eIF4E2 relieved miRNA repression of reporter expression...
July 28, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28755202/the-symbol-of-spread-of-modern-western-botany-into-china-chih-wu-hs%C3%A3-eh-an-unconventional-translation-in-the-late-qing-dynasty
#18
He Zhang
No abstract text is available yet for this article.
July 28, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28748452/single-cell-transcriptomics-reveals-gene-signatures-and-alterations-associated-with-aging-in-distinct-neural-stem-progenitor-cell-subpopulations
#19
Zhanping Shi, Yanan Geng, Jiping Liu, Huina Zhang, Liqiang Zhou, Quan Lin, Juehua Yu, Kunshan Zhang, Jie Liu, Xinpei Gao, Chunxue Zhang, Yinan Yao, Chong Zhang, Yi E Sun
Aging associated cognitive decline has been linked to dampened neural stem/progenitor cells (NSC/NPCs) activities manifested by decreased proliferation, reduced propensity to produce neurons, and increased differentiation into astrocytes. While gene transcription changes objectively reveal molecular alterations of cells undergoing various biological processes, the search for molecular mechanisms underlying aging of NSC/NPCs has been confronted by the enormous heterogeneity in cellular compositions of the brain and the complex cellular microenvironment where NSC/NPCs reside...
July 26, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28748451/the-emerging-role-and-targetability-of-the-tca-cycle-in-cancer-metabolism
#20
REVIEW
Nicole M Anderson, Patrick Mucka, Joseph G Kern, Hui Feng
The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells, and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early dogma that cancer cells bypass the TCA cycle and primarily utilize aerobic glycolysis, emerging evidence demonstrates that certain cancer cells, especially those with deregulated oncogene and tumor suppressor expression, rely heavily on the TCA cycle for energy production and macromolecule synthesis. As the field progresses, the importance of aberrant TCA cycle function in tumorigenesis and the potentials of applying small molecule inhibitors to perturb the enhanced cycle function for cancer treatment start to evolve...
July 26, 2017: Protein & Cell
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