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Protein & Cell

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https://www.readbyqxmd.com/read/29785567/si-ho-tchou-life-of-a-legend-from-physiology-to-psychology
#1
Wei Chen, Xi Chen, Shengjun Wen
No abstract text is available yet for this article.
May 21, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29752689/the-structure-differences-of-japanese-encephalitis-virus-sa14-and-sa14-14-2-e-proteins-elucidate-the-virulence-attenuation-mechanism
#2
LETTER
Xinyu Liu, Xin Zhao, Rui Na, Lili Li, Eberhard Warkentin, Jennifer Witt, Xu Lu, Yongxin Yu, Yuquan Wei, Guohong Peng, Yuhua Li, Junzhi Wang
No abstract text is available yet for this article.
May 11, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29736705/oral-microbiomes-more-and-more-importance-in-oral-cavity-and-whole-body
#3
REVIEW
Lu Gao, Tiansong Xu, Gang Huang, Song Jiang, Yan Gu, Feng Chen
Microbes appear in every corner of human life, and microbes affect every aspect of human life. The human oral cavity contains a number of different habitats. Synergy and interaction of variable oral microorganisms help human body against invasion of undesirable stimulation outside. However, imbalance of microbial flora contributes to oral diseases and systemic diseases. Oral microbiomes play an important role in the human microbial community and human health. The use of recently developed molecular methods has greatly expanded our knowledge of the composition and function of the oral microbiome in health and disease...
May 7, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29725936/insights-into-the-role-of-gut-microbiota-in-obesity-pathogenesis-mechanisms-and-therapeutic-perspectives
#4
Lijuan Sun, Lanjing Ma, Yubo Ma, Faming Zhang, Changhai Zhao, Yongzhan Nie
No abstract text is available yet for this article.
May 3, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29725935/gut-microbiota-derived-metabolites-in-cardiovascular-health-and-disease
#5
REVIEW
Zeneng Wang, Yongzhong Zhao
Trillions of microbes inhabit the human gut, not only providing nutrients and energy to the host from the ingested food, but also producing metabolic bioactive signaling molecules to maintain health and elicit disease, such as cardiovascular disease (CVD). CVD is the leading cause of mortality worldwide. In this review, we presented gut microbiota derived metabolites involved in cardiovascular health and disease, including trimethylamine-N-oxide (TMAO), uremic toxins, short chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids and lipopolysaccharide...
May 3, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29721778/microbes-and-host-dance-in-harmony-or-disarray
#6
EDITORIAL
Zhihua Liu
No abstract text is available yet for this article.
May 2, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29713943/the-association-of-diet-gut-microbiota-and-colorectal-cancer-what-we-eat-may-imply-what-we-get
#7
REVIEW
Jia Yang, Jun Yu
Despite the success of colonoscopy screening and recent advances in cancer treatment, colorectal cancer (CRC) still remains one of the most commonly diagnosed and deadly cancers, with a significantly increased incidence in developing countries where people are adapting to Western lifestyle. Diet has an important impact on risk of CRC. Multiple epidemiological studies have suggested that excessive animal protein and fat intake, especially red meat and processed meat, could increase the risk of developing CRC while fiber could protect against colorectal tumorigenesis...
April 30, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29705929/pharmacomicrobiomics-a-novel-route-towards-personalized-medicine
#8
REVIEW
Marwah Doestzada, Arnau Vich Vila, Alexandra Zhernakova, Debby P Y Koonen, Rinse K Weersma, Daan J Touw, Folkert Kuipers, Cisca Wijmenga, Jingyuan Fu
Inter-individual heterogeneity in drug response is a serious problem that affects the patient's wellbeing and poses enormous clinical and financial burdens on a societal level. Pharmacogenomics has been at the forefront of research into the impact of individual genetic background on drug response variability or drug toxicity, and recently the gut microbiome, which has also been called the second genome, has been recognized as an important player in this respect. Moreover, the microbiome is a very attractive target for improving drug efficacy and safety due to the opportunities to manipulate its composition...
April 28, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29696589/single-cell-metagenomics-challenges-and-applications
#9
REVIEW
Yuan Xu, Fangqing Zhao
With the development of high throughput sequencing and single-cell genomics technologies, many uncultured bacterial communities have been dissected by combining these two techniques. Especially, by simultaneously leveraging of single-cell genomics and metagenomics, researchers can greatly improve the efficiency and accuracy of obtaining whole genome information from complex microbial communities, which not only allow us to identify microbes but also link function to species, identify subspecies variations, study host-virus interactions and etc...
April 25, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29696588/simultaneous-and-systematic-analysis-of-cellular-and-viral-gene-expression-during-enterovirus-71-induced-host-shutoff
#10
LETTER
Yongquan Lin, Yan Wang, Hui Li, Yuhang Chen, Wentao Qiao, Zhi Xie, Juan Tan, Zhilong Yang
No abstract text is available yet for this article.
April 25, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29696587/chia-chen-tan-and-genetics-in-modern-china
#11
Lei Fu
No abstract text is available yet for this article.
April 25, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29691757/microbiota-transplantation-concept-methodology-and-strategy-for-its-modernization
#12
REVIEW
Faming Zhang, Bota Cui, Xingxiang He, Yuqiang Nie, Kaichun Wu, Daiming Fan
Fecal microbiota transplantation (FMT) has become a research focus of biomedicine and clinical medicine in recent years. The clinical response from FMT for different diseases provided evidence for microbiota-host interactions associated with various disorders, including Clostridium difficile infection, inflammatory bowel disease, diabetes mellitus, cancer, liver cirrhosis, gut-brain disease and others. To discuss the experiences of using microbes to treat human diseases from ancient China to current era should be important in moving standardized FMT forward and achieving a better future...
April 24, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29687363/engineering-vascularized-skeletal-muscle-tissue-with-transcriptional-factor-etv2-induced-autologous-endothelial-cells
#13
LETTER
Guanrong Yan, Ruibin Yan, Cheng Chen, Cheng Chen, Yanqiu Zhao, Wei Qin, Matthew B Veldman, Song Li, Shuo Lin
No abstract text is available yet for this article.
April 23, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29687362/terminal-transfer-amplification-and-sequencing-for-high-efficiency-and-low-bias-copy-number-profiling-of-fragmented-dna-samples
#14
LETTER
Dongqing Jiang, Xiannian Zhang, Yuhong Pang, Jianyun Zhang, Jianbin Wang, Yanyi Huang
No abstract text is available yet for this article.
April 23, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29679236/crtc2-modulates-hepatic-srebp1c-cleavage-by-controlling-insig2a-expression-during-fasting
#15
LETTER
Yuanyuan Zhang, Yi Liu, Liqun Chen, Yiguo Wang, Jinbo Han
No abstract text is available yet for this article.
April 20, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29679235/channel-activity-of-mirror-image-m2-proton-channel-of-influenza-a-virus-is-blocked-by-achiral-or-chiral-inhibitors
#16
LETTER
Qing-Yan Guo, Long-Hua Zhang, Chao Zuo, Dong-Liang Huang, Zhipeng A Wang, Ji-Shen Zheng, Chang-Lin Tian
No abstract text is available yet for this article.
April 20, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29675808/help-hope-and-hype-ethical-considerations-of-human-microbiome-research-and-applications
#17
Yonghui Ma, Hua Chen, Canhui Lan, Jianlin Ren
No abstract text is available yet for this article.
April 19, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29671201/cd146-a-potential-therapeutic-target-for-systemic-sclerosis
#18
LETTER
Lingling Zhang, Yongting Luo, Xiao Teng, Zhenzhen Wu, Mengtao Li, Dong Xu, Qian Wang, Fei Wang, Jing Feng, Xiaofeng Zeng, Xiyun Yan
No abstract text is available yet for this article.
April 18, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29667004/the-development-of-hiv-vaccines-targeting-gp41-membrane-proximal-external-region-mper-challenges-and-prospects
#19
REVIEW
Huan Liu, Xiaojie Su, Lulu Si, Lu Lu, Shibo Jiang
A human immunodeficiency virus type-1 (HIV-1) vaccine which is able to effectively prevent infection would be the most powerful method of extinguishing pandemic of the acquired immunodeficiency syndrome (AIDS). Yet, achieving such vaccine remains great challenges. The membrane-proximal external region (MPER) is a highly conserved region of the envelope glycoprotein (Env) gp41 subunit near the viral envelope surface, and it plays a key role in membrane fusion. It is also the target of some reported broadly neutralizing antibodies (bNAbs)...
April 17, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29667003/chemical-genomics-reveals-inhibition-of-breast-cancer-lung-metastasis-by-ponatinib-via-c-jun
#20
Wei Shao, Shasha Li, Lu Li, Kequan Lin, Xinhong Liu, Haiyan Wang, Huili Wang, Dong Wang
Metastasis is the leading cause of human cancer deaths. Unfortunately, no approved drugs are available for anti-metastatic treatment. In our study, high-throughput sequencing-based high-throughput screening (HTS2 ) and a breast cancer lung metastasis (BCLM)-associated gene signature were combined to discover anti-metastatic drugs. After screening of thousands of compounds, we identified Ponatinib as a BCLM inhibitor. Ponatinib significantly inhibited the migration and mammosphere formation of breast cancer cells in vitro and blocked BCLM in multiple mouse models...
April 17, 2018: Protein & Cell
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