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Protein & Cell

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https://www.readbyqxmd.com/read/29332267/inf-%C3%AE-a-new-spotlight-in-innate-immunity-against-influenza-virus-infection
#1
Yeping Sun, Jingwen Jiang, Po Tien, Wenjun Liu, Jing Li
No abstract text is available yet for this article.
January 13, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29318513/targeted-elimination-of-mutant-mitochondrial-dna-in-melas-ipscs-by-mitotalens
#2
Yi Yang, Han Wu, Xiangjin Kang, Yanhui Liang, Ting Lan, Tianjie Li, Tao Tan, Jiangyun Peng, Quanjun Zhang, Geng An, Yali Liu, Qian Yu, Zhenglai Ma, Ying Lian, Boon Seng Soh, Qingfeng Chen, Ping Liu, Yaoyong Chen, Xiaofang Sun, Rong Li, Xiumei Zhen, Ping Liu, Yang Yu, Xiaoping Li, Yong Fan
Mitochondrial diseases are maternally inherited heterogeneous disorders that are primarily caused by mitochondrial DNA (mtDNA) mutations. Depending on the ratio of mutant to wild-type mtDNA, known as heteroplasmy, mitochondrial defects can result in a wide spectrum of clinical manifestations. Mitochondria-targeted endonucleases provide an alternative avenue for treating mitochondrial disorders via targeted destruction of the mutant mtDNA and induction of heteroplasmic shifting. Here, we generated mitochondrial disease patient-specific induced pluripotent stem cells (MiPSCs) that harbored a high proportion of m...
January 9, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29302861/first-stem-cell-transplantation-to-regenerate-human-lung
#3
Si Wang, Jun Wu, Guang-Hui Liu
No abstract text is available yet for this article.
January 4, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29273853/antisense-transcription-regulates-the-expression-of-sense-gene-via-alternative-polyadenylation
#4
Ting Shen, Huan Li, Yifan Song, Jun Yao, Miao Han, Ming Yu, Gang Wei, Ting Ni
Natural antisense transcripts (NAT) and alternative polyadenylation (APA) of messenger RNA (mRNA) are important contributors of transcriptome complexity, each playing a critical role in multiple biological processes. However, whether they have crosstalk and function collaboratively is unclear. We discovered that APA enriched in human sense-antisense (S-AS) gene pairs, and finally focused on RNASEH2C-KAT5 S-AS pair for further study. In cis but not in trans over-expression of the antisense KAT5 gene promoted the usage of distal polyA (pA) site in sense gene RNASEH2C, which generated longer 3' untranslated region (3'UTR) and produced less protein, accompanying with slowed cell growth...
December 22, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29256010/mechanism-of-actions-of-oncocin-a-proline-rich-antimicrobial-peptide-in-early-elongation-revealed-by-single-molecule-fret
#5
LETTER
Sijia Peng, Mengyi Yang, Rui Ning Sun, Yang Liu, Wenjuan Wang, Qiaoran Xi, Haipeng Gong, Chunlai Chen
No abstract text is available yet for this article.
December 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29256009/dr-yang-zhong-an-explorer-on-the-road-forever
#6
Fan Chen, Bao-Rong Lu, James C Crabbe, Jia-Yuan Zhao, Bo-Jian Zhong, Yu-Peng Geng, Yu-Fang Zheng, Hong-Yan Wang
No abstract text is available yet for this article.
December 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29204946/gene-editing-using-crispr-cas9-implications-for-dual-use-and-biosecurity
#7
Diane DiEuliis, James Giordano
No abstract text is available yet for this article.
December 4, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29181831/molecular-guidance-cues-in-the-development-of-visual-pathway
#8
REVIEW
Yupu Diao, Yuqing Chen, Peijun Zhang, Liyuan Cui, Jiayi Zhang
70%-80% of our sensory input comes from vision. Light hit the retina at the back of our eyes and the visual information is relayed into the dorsal lateral geniculate nuclei (dLGN) and primary visual cortex (V1) thereafter, constituting the image-forming visual circuit. Molecular cues are one of the key factors to guide the wiring and refinement of the image-forming visual circuit during pre- and post-embryonic stages. Distinct molecular cues are involved in different developmental stages and nucleus, suggesting diverse guidance mechanisms...
November 27, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29168059/sec61%C3%AE-facilitates-the-maintenance-of-endoplasmic-reticulum-homeostasis-by-associating-microtubules
#9
Yimeng Zhu, Gangming Zhang, Shaoyu Lin, Juanming Shi, Hong Zhang, Junjie Hu
Sec61β, a subunit of the Sec61 translocon complex, is not essential in yeast and commonly used as a marker of endoplasmic reticulum (ER). In higher eukaryotes, such as Drosophila, deletion of Sec61β causes lethality, but its physiological role is unclear. Here, we show that Sec61β interacts directly with microtubules. Overexpression of Sec61β containing small epitope tags, but not a RFP tag, induces dramatic bundling of the ER and microtubule. A basic region in the cytosolic domain of Sec61β is critical for microtubule association...
November 22, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29164491/gene-activation-in-human-cells-using-crispr-cpf1-p300-and-crispr-cpf1-suntag-systems
#10
LETTER
Xin Zhang, Wei Wang, Lin Shan, Le Han, Shufeng Ma, Yan Zhang, Bingtao Hao, Ying Lin, Zhili Rong
No abstract text is available yet for this article.
November 21, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29143211/redirecting-t-cells-to-glypican-3-with-28-41bb-%C3%AE-and-28-%C3%AE-41bbl-cars-for-hepatocellular-carcinoma-treatment
#11
LETTER
Haili Ma, Siye Chen, Yan He, Jingwei Huang, Yanhong Xu, Chao Wang, Cheng Lei, Ting Lu, Shengdong Xiao, Jinming Mao, Yiyun Xu, Hao Guo, Bohua Li, Minghui Zhang, Xiaowen He
No abstract text is available yet for this article.
November 15, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29139028/histone-chaperone-spt16p-is-required-for-heterochromatin-mediated-silencing-in-budding-yeast
#12
LETTER
Xiaowei Yan, Jiayi Yang, Jiawei Xu, Jianxun Feng, Qing Li
No abstract text is available yet for this article.
November 14, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29139027/-magic-bullets-at-the-center-stage-of-immune-therapy-a-special-issue-on-therapeutic-antibodies
#13
EDITORIAL
Zhiqiang An
No abstract text is available yet for this article.
November 14, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29134516/structural-and-biochemical-insights-into-human-zinc-finger-protein-aebp2-reveals-interactions-with-rbbp4
#14
LETTER
Aiai Sun, Fudong Li, Zhonghua Liu, Yiyang Jiang, Jiahai Zhang, Jihui Wu, Yunyu Shi
No abstract text is available yet for this article.
November 13, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29080116/the-role-of-ubiquitination-and-deubiquitination-in-the-regulation-of-cell-junctions
#15
REVIEW
Junting Cai, Miranda K Culley, Yutong Zhao, Jing Zhao
Maintenance of cell junctions plays a crucial role in the regulation of cellular functions including cell proliferation, permeability, and cell death. Disruption of cell junctions is implicated in a variety of human disorders, such as inflammatory diseases and cancers. Understanding molecular regulation of cell junctions is important for development of therapeutic strategies for intervention of human diseases. Ubiquitination is an important type of post-translational modification that primarily regulates endogenous protein stability, receptor internalization, enzyme activity, and protein-protein interactions...
October 27, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29071574/professor-ju-chi-li-one-of-the-pioneers-and-founders-of-modern-genetics-in-china
#16
He Zhang
No abstract text is available yet for this article.
October 25, 2017: Protein & Cell
https://www.readbyqxmd.com/read/29058117/recapitulating-cortical-development-with-organoid-culture-in-vitro-and-modeling-abnormal-spindle-like-aspm-related-primary-microcephaly-disease
#17
Rui Li, Le Sun, Ai Fang, Peng Li, Qian Wu, Xiaoqun Wang
The development of a cerebral organoid culture in vitro offers an opportunity to generate human brain-like organs to investigate mechanisms of human disease that are specific to the neurogenesis of radial glial (RG) and outer radial glial (oRG) cells in the ventricular zone (VZ) and subventricular zone (SVZ) of the developing neocortex. Modeling neuronal progenitors and the organization that produces mature subcortical neuron subtypes during early stages of development is essential for studying human brain developmental diseases...
November 2017: Protein & Cell
https://www.readbyqxmd.com/read/28993977/questions-about-horse-spleen-ferritin-crossing-the-blood-brain-barrier-via-mouse-transferrin-receptor-1
#18
Kelong Fan, Meng Zhou, Xiyun Yan
No abstract text is available yet for this article.
November 2017: Protein & Cell
https://www.readbyqxmd.com/read/28986765/addressing-challenges-in-the-clinical-applications-associated-with-crispr-cas9-technology-and-ethical-questions-to-prevent-its-misuse
#19
Xiang Jin Kang, Chiong Isabella Noelle Caparas, Boon Seng Soh, Yong Fan
No abstract text is available yet for this article.
November 2017: Protein & Cell
https://www.readbyqxmd.com/read/28942539/correction-of-%C3%AE-thalassemia-mutant-by-base-editor-in-human-embryos
#20
Puping Liang, Chenhui Ding, Hongwei Sun, Xiaowei Xie, Yanwen Xu, Xiya Zhang, Ying Sun, Yuanyan Xiong, Wenbin Ma, Yongxiang Liu, Yali Wang, Jianpei Fang, Dan Liu, Zhou Songyang, Canquan Zhou, Junjiu Huang
β-Thalassemia is a global health issue, caused by mutations in the HBB gene. Among these mutations, HBB -28 (A>G) mutations is one of the three most common mutations in China and Southeast Asia patients with β-thalassemia. Correcting this mutation in human embryos may prevent the disease being passed onto future generations and cure anemia. Here we report the first study using base editor (BE) system to correct disease mutant in human embryos. Firstly, we produced a 293T cell line with an exogenous HBB -28 (A>G) mutant fragment for gRNAs and targeting efficiency evaluation...
November 2017: Protein & Cell
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