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Protein & Cell

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https://www.readbyqxmd.com/read/28766261/the-excessive-response-a-preparation-for-harder-conditions
#1
Yaguang Ren, Chao Zhang
No abstract text is available yet for this article.
August 1, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28755204/dr-chi-ming-chu-respected-founder-of-molecular-virology-and-pioneer-of-biologicals-in-china
#2
Weizheng Yan, Baoying Huang, Li Ruan, Wenjie Tan
No abstract text is available yet for this article.
July 28, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28755203/micrornas-recruit-eif4e2-to-repress-translation-of-target-mrnas
#3
Shaohong Chen, Guangxia Gao
MicroRNAs (miRNAs) recruit the RNA-induced silencing complex (RISC) to repress the translation of target mRNAs. While the 5' 7-methylguanosine cap of target mRNAs has been well known to be important for miRNA repression, the underlying mechanism is not clear. Here we show that TNRC6A interacts with eIF4E2, a homologue of eIF4E that can bind to the cap but cannot interact with eIF4G to initiate translation, to inhibit the translation of target mRNAs. Downregulation of eIF4E2 relieved miRNA repression of reporter expression...
July 28, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28755202/the-symbol-of-spread-of-modern-western-botany-into-china-chih-wu-hs%C3%A3-eh-an-unconventional-translation-in-the-late-qing-dynasty
#4
He Zhang
No abstract text is available yet for this article.
July 28, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28748452/single-cell-transcriptomics-reveals-gene-signatures-and-alterations-associated-with-aging-in-distinct-neural-stem-progenitor-cell-subpopulations
#5
Zhanping Shi, Yanan Geng, Jiping Liu, Huina Zhang, Liqiang Zhou, Quan Lin, Juehua Yu, Kunshan Zhang, Jie Liu, Xinpei Gao, Chunxue Zhang, Yinan Yao, Chong Zhang, Yi E Sun
Aging associated cognitive decline has been linked to dampened neural stem/progenitor cells (NSC/NPCs) activities manifested by decreased proliferation, reduced propensity to produce neurons, and increased differentiation into astrocytes. While gene transcription changes objectively reveal molecular alterations of cells undergoing various biological processes, the search for molecular mechanisms underlying aging of NSC/NPCs has been confronted by the enormous heterogeneity in cellular compositions of the brain and the complex cellular microenvironment where NSC/NPCs reside...
July 26, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28748451/the-emerging-role-and-targetability-of-the-tca-cycle-in-cancer-metabolism
#6
REVIEW
Nicole M Anderson, Patrick Mucka, Joseph G Kern, Hui Feng
The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells, and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early dogma that cancer cells bypass the TCA cycle and primarily utilize aerobic glycolysis, emerging evidence demonstrates that certain cancer cells, especially those with deregulated oncogene and tumor suppressor expression, rely heavily on the TCA cycle for energy production and macromolecule synthesis. As the field progresses, the importance of aberrant TCA cycle function in tumorigenesis and the potentials of applying small molecule inhibitors to perturb the enhanced cycle function for cancer treatment start to evolve...
July 26, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28733914/molecular-and-functional-analysis-of-monoclonal-antibodies-in-support-of-biologics-development
#7
REVIEW
Xin Wang, Zhiqiang An, Wenxin Luo, Ningshao Xia, Qinjian Zhao
Monoclonal antibody (mAb)-based therapeutics are playing an increasingly important role in the treatment or prevention of many important diseases such as cancers, autoimmune disorders, and infectious diseases. Multi-domain mAbs are far more complex than small molecule drugs with intrinsic heterogeneities. The critical quality attributes of a given mAb, including structure, post-translational modifications, and functions at biomolecular and cellular levels, need to be defined and profiled in details during the developmental phases of a biologics...
July 21, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28730546/mammalian-mitochondrial-rnas-are-degraded-in-the-mitochondrial-intermembrane-space-by-rnaset2
#8
Peipei Liu, Jinliang Huang, Qian Zheng, Leiming Xie, Xinping Lu, Jie Jin, Geng Wang
Mammalian mitochondrial genome encodes a small set of tRNAs, rRNAs, and mRNAs. The RNA synthesis process has been well characterized. How the RNAs are degraded, however, is poorly understood. It was long assumed that the degradation happens in the matrix where transcription and translation machineries reside. Here we show that contrary to the assumption, mammalian mitochondrial RNA degradation occurs in the mitochondrial intermembrane space (IMS) and the IMS-localized RNASET2 is the enzyme that degrades the RNAs...
July 20, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28717989/the-carma3-bcl10-malt1-cbm-complex-contributes-to-dna-damage-induced-nf-%C3%AE%C2%BAb-activation-and-cell-survival
#9
LETTER
Shilei Zhang, Deng Pan, Xin-Ming Jia, Xin Lin, Xueqiang Zhao
No abstract text is available yet for this article.
July 17, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28710747/phase-i-study-of-chimeric-antigen-receptor-modified-t-cells-in-treating-her2-positive-advanced-biliary-tract-cancers-and-pancreatic-cancers
#10
Kaichao Feng, Yang Liu, Yelei Guo, Jingdan Qiu, Zhiqiang Wu, Hanren Dai, Qingming Yang, Yao Wang, Weidong Han
This phase I clinical trial (NCT01935843) is to evaluate the safety, feasibility, and activity of chimeric antigen receptor-engineered T cell (CART) immunotherapy targeting human epidermal growth factor receptor 2 (HER2) in patients with advanced biliary tract cancers (BTCs) and pancreatic cancers (PCs). Eligible patients with HER2-positive (>50%) BTCs and PCs were enrolled in the trial. Well cultured CART-HER2 cells were infused following the conditioning treatment composed of nab-paclitaxel (100-200 mg/m(2)) and cyclophosphamide (15-35 mg/kg)...
July 14, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28695470/screening-novel-stress-granule-regulators-from-a-natural-compound-library
#11
LETTER
Li-Dan Hu, Xiang-Jun Chen, Xiao-Yan Liao, Yong-Bin Yan
No abstract text is available yet for this article.
July 10, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28688083/the-swi-snf-chromatin-remodeling-factors-baf60a-b-and-c-in-nutrient-signaling-and-metabolic-control
#12
REVIEW
Ruo-Ran Wang, Ran Pan, Wenjing Zhang, Junfen Fu, Jiandie D Lin, Zhuo-Xian Meng
Metabolic syndrome has become a global epidemic that adversely affects human health. Both genetic and environmental factors contribute to the pathogenesis of metabolic disorders; however, the mechanisms that integrate these cues to regulate metabolic physiology and the development of metabolic disorders remain incompletely defined. Emerging evidence suggests that SWI/SNF chromatin-remodeling complexes are critical for directing metabolic reprogramming and adaptation in response to nutritional and other physiological signals...
July 7, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28677105/carboxylesterases-in-lipid-metabolism-from-mouse-to-human
#13
REVIEW
Jihong Lian, Randal Nelson, Richard Lehner
Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro through (over)expression, knockdown of expression, and chemical inhibition in a variety of cells. Recent research advances have revealed the relevance of carboxylesterases to metabolic diseases such as obesity and fatty liver disease, suggesting these enzymes might be potential targets for treatment of metabolic disorders...
July 4, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28677104/the-dark-side-of-browning
#14
REVIEW
Kirstin A Tamucci, Maria Namwanje, Lihong Fan, Li Qiang
The induction of brown-like adipocyte development in white adipose tissue (WAT) confers numerous metabolic benefits by decreasing adiposity and increasing energy expenditure. Therefore, WAT browning has gained considerable attention for its potential to reverse obesity and its associated co-morbidities. However, this perspective has been tainted by recent studies identifying the detrimental effects of inducing WAT browning. This review aims to highlight the adverse outcomes of both overactive and underactive browning activity, the harmful side effects of browning agents, as well as the molecular brake-switch system that has been proposed to regulate this process...
July 4, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28677103/a-novel-therapeutic-anti-hbv-antibody-with-increased-binding-to-human-fcrn-improves-in-vivo-pk-in-mice-and-monkeys
#15
LETTER
Ciming Kang, Lin Xia, Yuanzhi Chen, Tianying Zhang, Yiwen Wang, Bing Zhou, Min You, Quan Yuan, Chi-Meng Tzeng, Zhiqiang An, Wenxin Luo, Ningshao Xia
No abstract text is available yet for this article.
July 4, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28677102/cle42-binding-induces-pxl2-interaction-with-serk2
#16
LETTER
Shulin Mou, Xiaoxiao Zhang, Zhifu Han, Jiawei Wang, Xinqi Gong, Jijie Chai
No abstract text is available yet for this article.
July 4, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28664251/structure-of-unliganded-membrane-proximal-domains-fn4-fn5-fn6-of-dcc
#17
LETTER
Lorenzo I Finci, Jie Zhang, Xiaqin Sun, Robert G Smock, Rob Meijers, Yan Zhang, Junyu Xiao, Jia-Huai Wang
No abstract text is available yet for this article.
June 29, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28646361/erratum-to-chimeric-antigen-receptor-car-modified-natural-killer-cell-based-immunotherapy-and-immunological-synapse-formation-in-cancer-and-hiv
#18
Dongfang Liu, Shuo Tian, Kai Zhang, Wei Xiong, Ndongala Michel Lubaki, Zhiying Chen, Weidong Han
No abstract text is available yet for this article.
June 23, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28643267/new-insight-into-inter-organ-crosstalk-contributing-to-the-pathogenesis-of-non-alcoholic-fatty-liver-disease-nafld
#19
REVIEW
Xu Zhang, Xuetao Ji, Qian Wang, John Zhong Li
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver dysfunction and a significant global health problem with substantial rise in prevalence over the last decades. It is becoming increasingly clear that NALFD is not only predominantly a hepatic manifestation of metabolic syndrome, but also involves extra-hepatic organs and regulatory pathways. Therapeutic options are limited for the treatment of NAFLD. Accordingly, a better understanding of the pathogenesis of NAFLD is critical for gaining new insight into the regulatory network of NAFLD and for identifying new targets for the prevention and treatment of NAFLD...
June 22, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28597152/glycosylation-engineering-of-therapeutic-igg-antibodies-challenges-for-the-safety-functionality-and-efficacy
#20
REVIEW
Yusuke Mimura, Toshihiko Katoh, Radka Saldova, Roisin O'Flaherty, Tomonori Izumi, Yuka Mimura-Kimura, Toshiaki Utsunomiya, Yoichi Mizukami, Kenji Yamamoto, Tsuneo Matsumoto, Pauline M Rudd
Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex-type oligosaccharide attached to Asn297 of the Fc is essential for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that generate structural heterogeneity (glycoforms) exhibit unique biological activities. Hence, efficient and quantitative glycan analysis techniques have been increasingly important for the development and quality control of therapeutic antibodies, and glycan profiles of the Fc are recognized as critical quality attributes...
June 8, 2017: Protein & Cell
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