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Protein & Cell

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https://www.readbyqxmd.com/read/27913985/erratum-to-questions-about-ngago
#1
Shawn Burgess, Linzhao Cheng, Feng Gu, Junjiu Huang, Zhiwei Huang, Shuo Lin, Jinsong Li, Wei Li, Wei Qin, Yujie Sun, Zhou Songyang, Wensheng Wei, Qiang Wu, Haoyi Wang, Xiaoqun Wang, Jing-Wei Xiong, Jianzhong Xi, Hui Yang, Bin Zhou, Bo Zhang
No abstract text is available yet for this article.
December 2, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27909985/il-25-blockade-inhibits-metastasis-in-breast-cancer
#2
Zhujun Jiang, Jingtao Chen, Xuemei Du, Hang Cheng, Xiaohu Wang, Chen Dong
Metastasis is the leading cause of death in breast cancer patients. However, the mechanisms underlying metastasis are not well understood and there is no effective treatment in the clinic. Here, we demonstrate that in MMTV-PyMT, a highly malignant spontaneous breast tumor model, IL-25 (also called IL-17E) was expressed by tumor-infiltrating CD4(+) T cells and macrophages. An IL-25 neutralization antibody, while not affecting primary tumor growth, substantially reduced lung metastasis. Inhibition of IL-25 resulted in decreased type 2 T cells and macrophages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subsequent metastasis to the lung...
December 1, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27909984/prof-shuch%C3%A3-n-teng-a-paragon-taxonomist-of-great-passion-and-firm-belief
#3
Guojie Li
No abstract text is available yet for this article.
December 1, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27909983/4-4-%C3%A3-resolution-cryo-em-structure-of-human-mtor-complex-1
#4
Huirong Yang, Jia Wang, Mengjie Liu, Xizi Chen, Min Huang, Dan Tan, Meng-Qiu Dong, Catherine C L Wong, Jiawei Wang, Yanhui Xu, Hong-Wei Wang
Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates signals from growth factors, cellular energy levels, stress and amino acids to control cell growth and proliferation through regulating translation, autophagy and metabolism. Here we determined the cryo-electron microscopy structure of human mTORC1 at 4.4 Å resolution. The mTORC1 comprises a dimer of heterotrimer (mTOR-Raptor-mLST8) mediated by the mTOR protein. The complex adopts a hollow rhomboid shape with 2-fold symmetry. Notably, mTORC1 shows intrinsic conformational dynamics...
December 1, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27900622/the-rising-young-scientist-stars-in-china
#5
Hao Cheng
No abstract text is available yet for this article.
November 29, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27882499/md-simulation-of-high-resolution-x-ray-structures-reveals-post-translational-modification-dependent-conformational-changes-in-hsf-dna-interaction
#6
LETTER
Han Feng, Sheng Wang, Ling Guo, Avinash S Punekar, Rudolf Ladenstein, Da-Cheng Wang, Wei Liu
No abstract text is available yet for this article.
November 23, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27878450/mass-spectrometry-based-proteomics-profiling-of-human-monocytes
#7
Yong Zeng, Fei-Yan Deng, Wei Zhu, Lan Zhang, Hao He, Chao Xu, Qing Tian, Ji-Gang Zhang, Li-Shu Zhang, Hong-Gang Hu, Hong-Wen Deng
Human monocyte is an important cell type which is involved in various complex human diseases. To better understand the biology of human monocytes and facilitate further studies, we developed the first comprehensive proteome knowledge base specifically for human monocytes by integrating both in vivo and in vitro datasets. The top 2000 expressed genes from in vitro datasets and 779 genes from in vivo experiments were integrated into this study. Altogether, a total of 2237 unique monocyte-expressed genes were cataloged...
November 22, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27866330/human-gut-microbiota-the-links-with-dementia-development
#8
REVIEW
Rashad Alkasir, Jing Li, Xudong Li, Miao Jin, Baoli Zhu
Dementia is a comprehensive category of brain diseases that is great enough to affect a person's daily functioning. The most common type of dementia is Alzheimer's disease, which makes most of cases. New researches indicate that gastrointestinal tract microbiota are directly linked to dementia pathogenesis through triggering metabolic diseases and low-grade inflammation progress. A novel strategy is proposed for the management of these disorders and as an adjuvant for psychiatric treatment of dementia and other related diseases through modulation of the microbiota (e...
November 19, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27858349/ngago-a-hope-or-a-hype
#9
EDITORIAL
Xiaoxue Zhang
No abstract text is available yet for this article.
November 17, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27848216/questions-about-ngago
#10
LETTER
Shawn Burgess, Linzhao Cheng, Feng Gu, Junjiu Huang, Zhiwei Huang, Shuo Lin, Jinsong Li, Wei Li, Wei Qin, Yujie Sun, Zhou Songyang, Wensheng Wei, Qiang Wu, Haoyi Wang, Xiaoqun Wang, Jing-Wei Xiong, Jianzhong Xi, Hui Yang, Bin Zhou, Bo Zhang
No abstract text is available yet for this article.
November 15, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27844448/mir-27b-inhibits-gastric-cancer-metastasis-by-targeting-nr2f2
#11
Qingzhao Feng, Xionglin Wu, Fuchao Li, Beibei Ning, Xiaofeng Lu, Yin Zhang, Ying Pan, Wenxian Guan
Increasing attention is focused on the down-regulation of miRNAs in cancer process. Nuclear receptor subfamily 2 (NR2F2, also known as COUP-TFII) is involved in the development of many types of cancers, but its role in gastric cancer remains elusive. In this experiment, oncomine and Kaplan-meier database revealed that NR2F2 was up-regulated in gastric cancer and that the high NR2F2 expression contributed to poor survival. MicroRNA-27b was targeted and down-regulated by NR2F2 in human gastric cancer tissues and cells...
November 14, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27844447/klebsiella-pneumoniae-ndpa-suppresses-erk-pathway-mediated-host-early-inflammatory-responses-and-is-degraded-through-the-ubiquitin-proteasome-pathway
#12
LETTER
Guanghua Xu, Jing Wang, Cui Hua Liu
No abstract text is available yet for this article.
November 14, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27830463/lrrk2-enhances-nod1-2-mediated-inflammatory-cytokine-production-by-promoting-rip2-phosphorylation
#13
Ruiqing Yan, Zhihua Liu
The innate immune system is critical for clearing infection, and is tightly regulated to avert excessive tissue damage. Nod1/2-Rip2 signaling, which is essential for initiating the innate immune response to bacterial infection and ER stress, is subject to many regulatory mechanisms. In this study, we found that LRRK2, encoded by a gene implicated in Crohn's disease, leprosy and familial Parkinson's disease, modulates the strength of Nod1/2-Rip2 signaling by enhancing Rip2 phosphorylation. LRRK2 deficiency markedly reduces cytokine production in macrophages upon Nod2 activation by muramyl dipeptide (MDP), Nod1 activation by D-gamma-Glu-meso-diaminopimelic acid (iE-DAP) or ER stress...
November 9, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27815826/rig-i-like-receptor-induced-irf3-mediated-pathway-of-apoptosis-ripa-a-new-antiviral-pathway
#14
REVIEW
Saurabh Chattopadhyay, Ganes C Sen
The innate immune response is the first line of host defense to eliminate viral infection. Pattern recognition receptors in the cytosol, such as RIG-I-like receptors (RLR) and Nod-like receptors (NLR), and membrane bound Toll like receptors (TLR) detect viral infection and initiate transcription of a cohort of antiviral genes, including interferon (IFN) and interferon stimulated genes (ISGs), which ultimately block viral replication. Another mechanism to reduce viral spread is through RIPA, the RLR-induced IRF3-mediated pathway of apoptosis, which causes infected cells to undergo premature death...
November 4, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27815825/domain-interactions-of-c-terminal-src-kinase-determined-through-nmr-spectroscopy-with-segmental-isotope-labeling
#15
LETTER
Dongsheng Liu, Ya Yuan, Rong Xu, David Cowburn
No abstract text is available yet for this article.
November 4, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27815824/mir-10a-inhibits-cell-proliferation-and-promotes-cell-apoptosis-by-targeting-bcl6-in-diffuse-large-b-cell-lymphoma
#16
Qian Fan, Xiangrui Meng, Hongwei Liang, Huilai Zhang, Xianming Liu, Lanfang Li, Wei Li, Wu Sun, Haiyang Zhang, Ke Zen, Chen-Yu Zhang, Zhen Zhou, Xi Chen, Yi Ba
The BCL6 (B-Cell Lymphoma 6) gene is a proto-oncogene that is often expressed in diffuse large B-cell lymphomas (DLBCLs). BCL6 loss of function can kill DLBCL cells, demonstrating that BCL6 is necessary for the survival of DLBCL cells and could be a therapeutic target. In this study, we found that BCL6 protein levels were consistently upregulated in DLBCL tissues, whereas its mRNA levels varied randomly in tissues, suggesting that a post-transcriptional mechanism was involved in BCL6 regulation. We used bioinformatics analysis to search for miRNAs, which potentially target BCL6, and identified specific targeting sites for miR-10a in the 3'-untranslated region (3'-UTR) of BCL6...
November 4, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27815823/hongfu-chu-world-renowned-entomologist
#17
Dayong Xue, Hongxiang Han
No abstract text is available yet for this article.
November 4, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27815822/crystal-clear-visualizing-the-intervention-mechanism-of-the-pd-1-pd-l1-interaction-by-two-cancer-therapeutic-monoclonal-antibodies
#18
REVIEW
Shuguang Tan, Danqing Chen, Kefang Liu, Mengnan He, Hao Song, Yi Shi, Jun Liu, Catherine W-H Zhang, Jianxun Qi, Jinghua Yan, Shan Gao, George F Gao
Antibody-based PD-1/PD-L1 blockade therapies have taken center stage in immunotherapies for cancer, with multiple clinical successes. PD-1 signaling plays pivotal roles in tumor-driven T-cell dysfunction. In contrast to prior approaches to generate or boost tumor-specific T-cell responses, antibody-based PD-1/PD-L1 blockade targets tumor-induced T-cell defects and restores pre-existing T-cell function to modulate antitumor immunity. In this review, the fundamental knowledge on the expression regulations and inhibitory functions of PD-1 and the present understanding of antibody-based PD-1/PD-L1 blockade therapies are briefly summarized...
November 4, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27785779/protein-protein-interaction-analysis-in-crude-bacterial-lysates-using-combinational-method-of-19-f-site-specific-incorporation-and-19-f-nmr
#19
LETTER
Dong Li, Yanan Zhang, Yao He, Chengwei Zhang, Jiefei Wang, Ying Xiong, Longhua Zhang, Yangzhong Liu, Pan Shi, Changlin Tian
No abstract text is available yet for this article.
October 27, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27761808/genome-wide-piggybac-transposon-mediated-screening-reveals-genes-related-to-reprogramming
#20
Xi Zhang, Xinglin Wei, Yuanyuan Wu, Yuzhe Wang, Cheng Tan, Xiaoxiang Hu, Ning Li, Mario R Capecchi, Sen Wu
No abstract text is available yet for this article.
October 19, 2016: Protein & Cell
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