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Therapeutic Advances in Endocrinology and Metabolism

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https://www.readbyqxmd.com/read/27540465/normothermic-thyroid-storm-an-unusual-presentation
#1
Anas Ahmad Sabir, Kabiru Sada, Bashir O Yusuf, Idris Aliyu
Thyroid storm is a rare life-threatening emergency due to thyrotoxicosis. A 30-year-old female presented with restlessness, tachycardia and vomiting but with normothermia which is an unusual presentation. There is the need for clinicians to be aware of atypical clinical features that can make the diagnosis of thyroid storm difficult.
August 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27540464/%C3%AE-cell-replacement-sources-for-type-1-diabetes-a-focus-on-pancreatic-ductal-cells
#2
REVIEW
Elisa Corritore, Yong-Syu Lee, Etienne M Sokal, Philippe A Lysy
Thorough research on the capacity of human islet transplantation to cure type 1 diabetes led to the achievement of 3- to 5-year-long insulin independence in nearly half of transplanted patients. Yet, translation of this technique to clinical routine is limited by organ shortage and the need for long-term immunosuppression, restricting its use to adults with unstable disease. The production of new bona fide β cells in vitro was thus investigated and finally achieved with human pluripotent stem cells (PSCs)...
August 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27540463/methimazole-induced-insulin-autoimmune-syndrome
#3
REVIEW
Nidhi Jain, Malvi Savani, Manyoo Agarwal, Dipen Kadaria
BACKGROUND: Hypoglycemia in a critical care setting is often multifactorial with iatrogenic insulin use, sulfonylurea (SU) use, sepsis, adrenal insufficiency and insulinoma among the common causes. Insulin autoimmune syndrome (IAS) is a rare cause of hypoglycemia characterized by the presence of insulin-binding autoantibodies to the sulfhydryl group-containing agents. We report a case of methimazole-induced IAS managed in the intensive care unit. CASE PRESENTATION: A 76-year-old woman with a history of primary hyperthyroidism was sent from a nursing home for unresponsiveness...
August 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27540462/treatment-with-insulin-analogs-especially-glargine-and-lispro-associates-with-better-renal-function-and-higher-hemoglobin-levels-in-type-1-diabetic-patients-with-impaired-kidney-function
#4
Christoph Hasslacher, Felix Kulozik, Justo Lorenzo Bermejo
OBJECTIVES: The influence of type of insulin treatment - insulin analogs versus human insulin - on the development of diabetes related vascular complications has been sparsely investigated. We examine here possible differences regarding kidney function and hemoglobin levels. METHODS: Multiple linear regression was used to investigate the relationship between the following characteristics measured in 509 type 1 diabetic patients who were recruited in an outpatient practice: current clinical status and treatment modalities, type of injected insulin and the routine laboratory parameters hemoglobin, HbA1c, serum creatinine, eGFR, hs CRP and urinary albumin/creatinine ratio...
August 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27540461/effect-of-vitamin-d-supplementation-on-cardiovascular-disease-risk-factors-and-exercise-performance-in-healthy-participants-a-randomized-placebo-controlled-preliminary-study
#5
Emad A S Al-Dujaili, Nimrah Munir, Raquel Revuelta Iniesta
BACKGROUND AND OBJECTIVES: Evidence suggests associations between vitamin D deficiency and cardiovascular disease (CVD) risk factors, including hypertension and excessive cortisol levels. Also, vitamin D levels may impact exercise performance. Thus, we aimed to investigate the effects of vitamin D intake on cardiovascular risk factors, free urinary cortisol and exercise performance. METHODS: A randomized placebo-controlled single-blinded parallel trial was conducted in healthy participants (n = 15)...
August 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27293542/review-of-vancomycin-induced-renal-toxicity-an-update
#6
REVIEW
Oluwatoyin Bamgbola
In recent times the use of larger doses of vancomycin aimed at curbing the increasing incidence of resistant strains of Staphylococcus aureus has led to a wider report of acute kidney injury (AKI). Apart from biological plausibility, causality is implied by the predictive association of AKI with larger doses, longer duration, and graded plasma concentrations of vancomycin. AKI is more likely to occur with the concurrent use of nephrotoxic agents, and in critically ill patients who are susceptible to poor renal perfusion...
June 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27293541/osteoporosis-in-liver-disease-pathogenesis-and-management
#7
REVIEW
Gabriela Handzlik-Orlik, Michał Holecki, Krzysztof Wilczyński, Jan Duława
Osteoporosis affects a substantial proportion of patients with chronic liver disease. Pathologic fracture in osteoporosis significantly affects quality of life and life expectancy. By some estimates, 40% of patients with chronic liver disease may experience osteoporotic fracture. In this study we review the pathogenesis, diagnosis and treatment of specific liver disease entities and their relation to osteoporosis.
June 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27293540/metabolic-consequences-of-modern-immunosuppressive-agents-in-solid-organ-transplantation
#8
REVIEW
Oluwatoyin Bamgbola
Among other factors, sophistication of immunosuppressive (IS) regimen accounts for the remarkable success attained in the short- and medium-term solid organ transplant (SOT) survival. The use of steroids, mycophenolate mofetil and calcineurin inhibitors (CNI) have led to annual renal graft survival rates exceeding 90% in the last six decades. On the other hand, attrition rates of the allograft beyond the first year have remained unchanged. In addition, there is a persistent high cardiovascular (CV) mortality rate among transplant recipients with functioning grafts...
June 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27293539/management-of-diabetes-in-morocco-results-of-the-international-diabetes-management-practices-study-idmps-wave-5
#9
Asmae Chadli, Siham El Aziz, Nawal El Ansari, Farida Ajdi, Mehdi Seqat, Hanane Latrech, Ghizlaine Belmejdoub
OBJECTIVES: The International Diabetes Mellitus Practice Study (IDMPS) is a 5-year survey documenting changes in diabetes treatment practices in developing countries. The primary objective of this survey was to assess the therapeutic management of type 2 diabetes mellitus (T2DM) in real-life medical practice. The secondary objectives were to evaluate the clinical management of type 1 diabetes mellitus (T1DM) and to assess the proportion of all diabetic patients failing to reach the glycated haemoglobin (HbA1c) <7% target...
June 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27293538/seven-years-of-follow-up-of-trabecular-bone-score-bone-mineral-density-body-composition-and-quality-of-life-in-adults-with-growth-hormone-deficiency-treated-with-rhgh-replacement-in-a-single-center
#10
Gonzalo Allo Miguel, Alicia Serraclara Plá, Myriam Lorena Partida Muñoz, Guillermo Martínez Díaz-Guerra, Federico Hawkins
BACKGROUND: Adult growth hormone deficiency (AGHD) is characterized by impaired physical activity, diminished quality of life (QoL), weight and fat mass gain, decreased muscle mass and decreased bone mineral density (BMD). The aim of this study was to evaluate the effects of long-term treatment (7 years) with recombinant human growth hormone (rhGH) on metabolic parameters, body composition (BC), BMD, bone microarchitecture and QoL. PATIENTS AND METHODS: In this prospective study, BMD and BC were assessed by dual-energy X-ray absorptiometry (DXA)...
June 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27092233/glibenclamide-induced-profound-hypoglycaemic-crisis-a-case-report
#11
Arshad Hussain, Iftikhar Ali, Aziz Ullah Khan, Tahir Mehmood Khan
The value of sulphonylureas in the long-term treatment of type II diabetes has been questioned. The potential benefits of an antidiabetic drug must be carefully weighed against the risk of developing hazardous adverse effects like hypoglycaemia. We present drug-induced hypoglycaemia in a 77-year-old Pakistani male who had hypertension, type II diabetes and renal parenchymal disease (grade I), presented to the emergency department complaining of a 1-day history of fever, loose motions and drowsiness. His fever was low grade, intermittent, and not associated with rigors and chills...
April 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27092232/clinically-and-pharmacologically-relevant-interactions-of-antidiabetic-drugs
#12
REVIEW
Marcus May, Christoph Schindler
Patients with type 2 diabetes mellitus often require multifactorial pharmacological treatment due to different comorbidities. An increasing number of concomitantly taken medications elevate the risk of the patient experiencing adverse drug effects or drug interactions. Drug interactions can be divided into pharmacokinetic and pharmacodynamic interactions affecting cytochrome (CYP) enzymes, absorption properties, transporter activities and receptor affinities. Furthermore, nutrition, herbal supplements, patient's age and gender are of clinical importance...
April 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27092231/chemerin-as-an-independent-predictor-of-cardiovascular-event-risk
#13
REVIEW
Sinan İnci, Gökhan Aksan, Pınar Doğan
Currently, coronary artery disease (CAD) is considered a major ailment in humans with widespread prevalence. CAD also accounts for high mortality rates around the world that involves several known risk factors. Chemerin is a novel adipokinine that is associated with inflammation and adipogenesis. Furthermore, experimental and clinical data indicate that localized as well as circulating chemerin expression and activation are elevated in numerous metabolic and inflammatory diseases including psoriasis, obesity, type 2 diabetes, metabolic syndrome and cardiovascular disease...
April 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27092230/serum-chemerin-and-high-sensitivity-c-reactive-protein-as-markers-of-subclinical-atherosclerosis-in-egyptian-patients-with-type-2-diabetes
#14
Nagwa A Lachine, Abdel Aziz Elnekiedy, Magdy Helmy Megallaa, Gihane I Khalil, Mohamed A Sadaka, Kamel H Rohoma, Heba S Kassab
CONTEXT: Chemerin is one of the adipokines that regulate fat metabolism. High-sensitivity C-reactive protein (hs-CRP) may be considered as a cardiovascular risk predictor. Measuring intima-media thickness of the CCA (C-IMT) is a well-evidenced tool for the detection of early stages of atherosclerosis. We aimed here to study both serum chemerin and hs-CRP as markers of subclinical atherosclerosis in Egyptian patients with type 2 diabetes, who are angiographically free of coronary artery disease (CAD)...
April 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26885360/stimulation-of-incretin-secreting-cells
#15
REVIEW
Ramona Pais, Fiona M Gribble, Frank Reimann
The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon like peptide-1 (GLP-1) are secreted from enteroendocrine cells in the gut and regulate physiological and homeostatic functions related to glucose control, metabolism and food intake. This review provides a systematic summary of the molecular mechanisms underlying secretion from incretin cells, and an understanding of how they sense and interact with lumen and vascular factors and the enteric nervous system through transporters and G-protein coupled receptors (GPCRs) present on their surface to ultimately culminate in hormone release...
February 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26885359/levothyroxine-treatment-of-mild-subclinical-hypothyroidism-a-review-of-potential-risks-and-benefits
#16
REVIEW
Zeeshan Javed, Thozhukat Sathyapalan
Subclinical hypothyroidism (SCH) is defined as elevated thyroid stimulating hormone (TSH) with normal levels of free triiodothyronine (FT3) and free thyroxine (FT4). SCH is further classified into a milder condition with TSH levels between 4.0 and 10.0 milli-international units (mIU)/l (mild-SCH) and a severe form with TSH >10.0 mIU/l (severe-SCH). SCH is a common problem (prevalence is greater in women than men), which increases further with increasing age and TSH levels. Even though the risk of progression to overt hypothyroidism is higher in patients with severe-SCH, the risk is also significant in patients having mild-SCH; it has been suggested that every twofold rise in serum TSH would increase the risk from 1 to 4%, which further increases to 38% if thyroid antibodies are positive...
February 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26885358/an-investigation-of-the-associations-among-sleep-duration-and-quality-body-mass-index-and-insulin-resistance-in-newly-diagnosed-type-2-diabetes-mellitus-patients
#17
Teresa Arora, Mimi Z Chen, Omar M Omar, Ashley R Cooper, Rob C Andrews, Shahrad Taheri
OBJECTIVES: To examine direct and indirect associations of sleep duration and quality with insulin resistance, considering body mass index (BMI) as a potential mediator in newly diagnosed type 2 diabetes mellitus patients. METHODS: Cross-sectional data from patients enrolled in the Early Activity in Diabetes study. We studied 522 newly diagnosed type 2 diabetes mellitus patients, 65.9% male, mean age 63.5 ± 10.1 years. Of the total sample 53% had a BMI of ⩾30 kg/m(2)...
February 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26623005/the-obesity-of-bone
#18
REVIEW
Emanuela A Greco, Andrea Lenzi, Silvia Migliaccio
During the last decades, obesity and osteoporosis have become important global health problems, and the belief that obesity is protective against osteoporosis has recently come into question. In fact, some recent epidemiologic and clinical studies have shown that a high level of fat mass might be a risk factor for osteoporosis and fragility fractures. Several potential mechanisms have been proposed to explain the complex relationship between adipose tissue and bone. Indeed, adipose tissue secretes various molecules, named adipokines, which are thought to have effects on metabolic, skeletal and cardiovascular systems...
December 2015: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26623004/pregnancy-in-acromegaly
#19
REVIEW
Bashir A Laway
With advances in surgical and medical treatment and the availability of assisted reproductive techniques, pregnancy in women with acromegaly is more frequently encountered. Diagnosis of acromegaly during pregnancy is difficult because of changes in growth hormone and insulin like growth factor-1 (IGF-1) axis secondary to placental production of growth hormone. The difficulty is compounded by the inability of routine hormone assays to detect placental growth hormone. In the majority of patients with acromegaly, pregnancy does not have an adverse effect on mother or fetus and pituitary mass does not increase in size...
December 2015: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26623003/comparison-of-conventional-risk-factors-in-middle-aged-versus-elderly-diabetic-and-nondiabetic-patients-with-myocardial-infarction-prediction-with-decision-analytic-model
#20
Mohammad Reza Mahmoodi, Mohammad Reza Baneshi, Azam Rastegari
BACKGROUND: We sought to predict occurrence of myocardial infarction (MI) by means of a classification and regression tree (CART) model by conventional risk factors in middle-aged versus elderly (age ⩾65years) diabetic and nondiabetic patients from the Modares Heart Study. METHOD: A total of 469 patients were randomly selected and categorized into two groups according to clinical diabetes status. Group I consisted of 238 diabetic patients and group II consisted of 231 nondiabetic patients...
December 2015: Therapeutic Advances in Endocrinology and Metabolism
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