journal
MENU ▼
Read by QxMD icon Read
search

Clinical and Translational Gastroenterology

journal
https://www.readbyqxmd.com/read/29720629/aspirin-the-miracle-drug
#1
EDITORIAL
Prashanthi N Thota
Aspirin use is associated with reduction of esophageal adenocarcinoma but it is not known if it does so by preventing the development of Barrett's esophagus or by reducing neoplastic progression in patients with Barrett's esophagus. There is sparse literature to support the former assumption especially in women. This study by Jovani et al. based on Nurses' Health Study reports 27% lower risk of Barrett's esophagus among women using aspirin. The protective effect seems to increase with higher frequency and longer duration of aspirin use...
May 2, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29712897/optical-detection-of-field-cancerization-in-the-buccal-mucosa-of-patients-with-esophageal-cancer
#2
Oisín Bugter, Manon C W Spaander, Marco J Bruno, Robert J Baatenburg de Jong, Arjen Amelink, Dominic J Robinson
INTRODUCTION: Esophageal cancer is an increasingly common type of neoplasm with a very poor prognosis. This prognosis could improve with more early tumor detection. We have previously shown that we can use an optical spectroscopy to detect field cancerization in the buccal mucosa of patients with laryngeal cancer. The aim of this prospective study was to investigate whether we could detect field cancerization of buccal mucosa of patients with esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)...
April 30, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29712892/sequencing-of-intraductal-biopsies-is-feasible-and-potentially-impacts-clinical-management-of-patients-with-indeterminate-biliary-stricture-and-cholangiocarcinoma
#3
Katrin Bankov, Claudia Döring, Markus Schneider, Sylvia Hartmann, Ria Winkelmann, Joerg G Albert, Wolf Otto Bechstein, Stefan Zeuzem, Martin Leo Hansmann, Jan Peveling-Oberhag, Dirk Walter
BACKGROUND: Definite diagnosis and therapeutic management of cholangiocarcinoma (CCA) remains a challenge. The aim of the current study was to investigate feasibility and potential impact on clinical management of targeted sequencing of intraductal biopsies. METHODS: Intraductal biopsies with suspicious findings from 16 patients with CCA in later clinical course were analyzed with targeted sequencing including tumor and control benign tissue (n = 55 samples)...
April 30, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691386/toll-like-receptors-mediated-pathways-activate-inflammatory-responses-in-the-esophageal-mucosa-of-adult-eosinophilic-esophagitis
#4
Ángel Arias, María Vicario, David Bernardo, José M Olalla, Marina Fortea, Ana Montalban-Arques, Pilar Martínez-Fernández, Ana M González-Castro, Teresa Mota-Huertas, Laura Arias-González, Alfredo J Lucendo
OBJECTIVES: Esophageal microbiota and regulation of adaptive immunity are increasingly being investigated in eosinophilic esophagitis (EoE). Toll-like receptors (TLRs) play a central role in the initiation and maintenance of innate immune activity. Our objective was to characterize the esophageal and duodenal innate immune response in EoE and its modulation by dietary therapy. METHODS: Esophageal and duodenal biopsy samples were collected from 10 adults with untreated EoE, before and after effective treatment with a six-food elimination diet (SFED), and 10 controls with normal esophagus...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691384/blood-transfusion-strategies-for-acute-upper-gastrointestinal-bleeding-are-we-back-where-we-started
#5
EDITORIAL
Andrew W Yen
Blood transfusion practices for acute upper gastrointestinal hemorrhage have changed over time. Restrictive strategies, which gave way to more liberal approaches for the greater part of the 20th century, have again gained traction as emerging research suggests restricting transfusion is associated with similar, or possibly better outcomes in UGI bleeding. In a large, retrospective cohort study from an integrated health care system in Taiwan, Chen, et al., report the association between early blood transfusion and clinical outcomes in patients presenting to the emergency department with UGI bleeding, and these findings are discussed in the context of current knowledge and practice...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691379/mental-and-physical-health-related-quality-of-life-in-patients-with-hepatitis-c-is-related-to-baseline-comorbidities-and-improves-only-marginally-with-hepatitis-c-cure
#6
Paul J Thuluvath, Yulia Savva
The objective of the study was to analyze the relationship between patient characteristics and the health-related quality of life (HRQoL) among patients with hepatitis C at the start of treatment, 2-12 weeks of treatment and ≥3 months post treatment using Short-Form 36 (SF-36). The eight domains and two composite scores of SF-36 were analyzed using 236 individuals. Compared to US general population norms, on average, the physical health scores were significantly lower for the studied hepatitis C population, while the differences related to mental health were between zero and small...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691377/colonic-motor-response-to-wakening-is-blunted-in-slow-transit-constipation-as-detected-by-wireless-motility-capsule
#7
Brian Surjanhata, Kenneth Barshop, Kyle Staller, Jack Semler, Laurence Guay, Braden Kuo
BACKGROUND: Chronic constipation may be categorized as normal transit (NTC), slow transit (STC), or outlet obstruction. Colonic wake response is a relative increase in colonic motility upon awakening. Colonic manometry studies have demonstrated attenuated wake response in STC. We sought to evaluate wake response among healthy (H), NTC, and STC patients using wireless motility capsule (WMC). METHODS: A retrospective study of WMC data from a multicenter clinical trial and a tertiary gastroenterology clinic was performed...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691369/does-colectomy-predispose-to-small-intestinal-bacterial-sibo-and-fungal-overgrowth-sifo
#8
Satish S C Rao, George Tan, Hamza Abdulla, Siegfried Yu, Sebastian Larion, Pornchai Leelasinjaroen
OBJECTIVES: After subtotal colectomy, 40% of patients report chronic gastrointestinal symptoms and poor quality of life. Its etiology is unknown. We determined whether small intestinal bacterial overgrowth (SIBO) or small intestinal fungal overgrowth (SIFO) cause gastrointestinal symptoms after colectomy. METHODS: Consecutive patients with unexplained abdominal pain, gas, bloating and diarrhea (>1 year), and without colectomy (controls), and with colectomy were evaluated with symptom questionnaires, glucose breath test (GBT) and/or duodenal aspiration/culture...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691365/plasma-inflammatory-cytokines-and-survival-of-pancreatic-cancer-patients
#9
A Babic, N Schnure, N P Neupane, M M Zaman, N Rifai, M W Welch, L K Brais, D A Rubinson, V Morales-Oyarvide, C Yuan, S Zhang, E M Poole, B M Wolpin, M H Kulke, D A Barbie, K Wong, C S Fuchs, K Ng
OBJECTIVES: Inflammation and inflammatory conditions have been associated with pancreatic cancer risk and progression in a number of clinical, epidemiological, and animal model studies. The goal of the present study is to identify plasma markers of inflammation associated with survival of pancreatic cancer patients, and assess their joint contribution to patient outcome. METHODS: We measured circulating levels of four established markers of inflammation (C-reactive protein (CRP), interleukin-6 (IL-6), soluble tumor necrosis factor receptor type II (sTNF-RII), and macrophage inhibitory cytokine-1 (MIC-1)) in 446 patients enrolled in an ongoing prospective clinic-based study...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691364/primary-care-colorectal-cancer-screening-correlates-with-breast-cancer-screening-implications-for-colorectal-cancer-screening-improvement-interventions
#10
Jennifer M Weiss, Nancy Pandhi, Sally Kraft, Aaron Potvien, Pascale Carayon, Maureen A Smith
OBJECTIVE: National colorectal cancer (CRC) screening rates have plateaued. To optimize interventions targeting those unscreened, a better understanding is needed of how this preventive service fits in with multiple preventive and chronic care needs managed by primary care providers (PCPs). This study examines whether PCP practices of other preventive and chronic care needs correlate with CRC screening. METHODS: We performed a retrospective cohort study of 90 PCPs and 33,137 CRC screening-eligible patients...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29618721/risk-of-thrombosis-and-mortality-in-inflammatory-bowel-disease
#11
Adriana R Andrade, Luísa L Barros, Matheus F C Azevedo, Alexandre S Carlos, Aderson O M C Damião, Aytan M Sipahi, André Z A Leite
OBJECTIVES: Patients with inflammatory bowel disease have a higher risk of thrombosis, which is associated with a higher morbidity and mortality. Most data about VTE are related to hospitalized patients with active disease, but several cases happen in the outpatient setting, and are not covered by current prophylaxis recommendation. As the knowledge of VTE in outpatients is still poor, the aim of this study is to evaluate the risk, clinical data and mortality of thrombosis in patients followed in our center, comparing our findings with the current prophylaxis recommendation...
April 3, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29618720/anti-tnf-and-thiopurine-therapy-in-pregnant-ibd-patients-does-not-significantly-alter-a-panel-of-b-cell-and-t-cell-subsets-in-1-year-old-infants
#12
Michael G Kattah, Jeffrey M Milush, Trevor Burt, Robert P McCabe, Michael I Whang, Averil Ma, Uma Mahadevan
OBJECTIVES: Infants exposed to combination therapy with anti-tumor necrosis factor (anti-TNF) agents and thiopurines may exhibit increased infections at 1 year of age compared to unexposed infants. We hypothesized that this increased risk of infection is due to abnormal development of the newborn immune system. METHODS: We immunophenotyped B-cell and T-cell subsets using multiparameter flow cytometry in 1-year-old infants whose mothers were exposed to therapeutic agents for IBD...
April 3, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29599508/the-association-between-red-blood-cell-transfusion-and-outcomes-in-patients-with-upper-gastrointestinal-bleeding
#13
Yi-Chuan Chen, Cheng-Ting Hsiao, Leng-Chieh Lin, Kuang-Yu Hsiao, Ming-Szu Hung
BACKGROUND: The benefits of transfusion for acute upper gastrointestinal bleeding (UGIB) have not been well established; however, previous studies suggest that transfusion is associated with adverse outcomes. We performed an observational study using a 10-year database to analyze the association between red blood cell (RBC) transfusion and outcomes in patients with UGIB in the emergency department (ED). METHOD AND FINDINGS: All adult patients with UGIB were identified through diagnostic codes...
March 29, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29599487/baclofen-and-gastroesophageal-reflux-disease-seeing-the-forest-through-the-trees
#14
EDITORIAL
John O Clarke, Nielsen Q Fernandez-Becker, Kirsten A Regalia, George Triadafilopoulos
Baclofen has been shown to decrease reflux events and increase lower esophageal sphincter pressure, yet has never established a clear role in the treatment of gastroesophageal reflux disease (GERD). Lei and colleagues have shown in a recent elegant study that baclofen reduces the frequency and initiation of secondary peristalsis and heightens esophageal sensitivity to capsaicin-mediated stimulation. These findings may help explain both the benefit of baclofen in conditions such as rumination and supragastric belching, as well as the apparent lack of benefit of baclofen and other GABAB agonists in long-term treatment of GERD...
March 29, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29540676/increasing-co-morbidities-in-chronic-hepatitis-b-patients-experience-in-primary-care-and-referral-practices-during-2000-2015
#15
Anne Liu, An Le, Jian Zhang, Chris Wong, Clifford Wong, Linda Henry, Mindie H Nguyen
OBJECTIVES: Data on liver and non-liver co-morbidities in chronic hepatitis B (CHB) patients are limited. This study analyzes the prevalence of co-morbidities in a multicenter CHB cohort evaluated over 15 years. METHODS: This study included 2734 consecutive adult American CHB patients from a university medical center and several community primary care clinics. Data were analyzed by time periods (patients in each time period were unique without overlapping): 2000-2005 (n = 885), 2006-2010 (n = 888), and 2011-2015 (n = 961)...
March 14, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29511165/food-allergen-triggers-are-increased-in-children-with-the-tslp-risk-allele-and-eosinophilic-esophagitis
#16
Lisa M Fahey, Prasanna M Chandramouleeswaran, Shaobo Guan, Alain J Benitez, Glenn T Furuta, Seema S Aceves, Mei-Lun Wang, Chris A Liacouras, Amanda B Muir, Patrick Ma Sleiman, Hakon Hakonarson, Jonathan M Spergel, Antonella Cianferoni
OBJECTIVES: TSLP has been shown to be associated with eosinophilic esophagitis (EoE). Specifically, children with EoE often have the nucleotides AA or AG instead of GG at the single nucleotide polymorphism position RS3806932. Presently, the phenotypic characteristics in EoE children with the TSLP EoE risk allele are unknown. METHODS: A retrospective analysis was performed of all children with EoE who had TSLP genotyping at The Children's Hospital of Philadelphia from 2008-2014...
March 6, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29511162/increased-risk-of-venous-thromboembolism-in-hospitalized-patients-with-cirrhosis-due-to-non-alcoholic-steatohepatitis
#17
Jonathan G Stine, Blake A Niccum, Alex N Zimmet, Nicolas Intagliata, Stephen H Caldwell, Curtis K Argo, Patrick G Northup
OBJECTIVE: Patients with cirrhosis are at increased risk for venous thromboembolism (VTE) and portal vein thrombosis (PVT). Cirrhosis due to non-alcoholic steatohepatitis (NASH) appears to be particularly prothrombotic. We investigated hospitalized patients with NASH cirrhosis to determine if they are at increased risk for VTE. METHODS: Data on adult hospitalized patients with cirrhosis and VTE (deep vein thrombosis and/or pulmonary embolism) between November 1, 2010 and December 31, 2015 were obtained...
March 6, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29491399/barrett-s-esophagus-is-associated-with-a-distinct-oral-microbiome
#18
Erik J Snider, Griselda Compres, Daniel E Freedberg, Marla J Giddins, Hossein Khiabanian, Charles J Lightdale, Yael R Nobel, Nora C Toussaint, Anne-Catrin Uhlemann, Julian A Abrams
OBJECTIVES: The esophageal microbiome is composed of predominantly oral flora and is altered in reflux-related conditions including Barrett's esophagus (BE). Changes to the esophageal microbiome may be reflected in the oral cavity. Assessing the oral microbiome thus represents a potential non-invasive method to identify patients with BE. METHODS: Patients with and without BE undergoing upper endoscopy were prospectively enrolled. Demographics, clinical data, medications, and dietary intake were assessed...
February 20, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29491393/endoscopic-score-vs-fecal-biomarkers-for-predicting-relapse-in-patients-with-ulcerative-colitis-after-clinical-remission-and-mucosal-healing
#19
Takayuki Yamamoto, Takahiro Shimoyama, Satoru Umegae, Koichi Matsumoto
Achieving endoscopic remission or decreasing the level of fecal biomarkers as an ideal therapeutic goal in ulcerative colitis has not been determined. This prospective study was to compare the clinical relevance of endoscopic score with fecal biomarkers for predicting relapse after clinical remission and mucosal healing (MH). One hundred and sixty-four patients who achieved clinical remission and MH (Mayo endoscopic subscore (MES) 0 or 1) were included. At entry, fecal samples were collected for the measurement of calprotectin, lactoferrin, and hemoglobin...
February 20, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29446765/gut-microbiota-based-therapies-for-irritable-bowel-syndrome
#20
Emily K Stern, Darren M Brenner
Irritable bowel syndrome (IBS) is a common, heterogeneous disorder characterized by abdominal pain associated with changes in bowel habits. The pathogenesis of IBS is multifactorial and may relate to alterations in the gut microbiota, changes in visceral sensation and motility, and genetic and environmental factors. Administration of systemic antibiotics may increase the risk of IBS by altering gastrointestinal homeostasis. Therapeutic interventions for IBS with diarrhea that are thought to target alterations in the gut microbiota include the nonsystemic antibiotic rifaximin, the medical food serum-derived bovine immunoglobulin, prebiotics, probiotics, and dietary modification...
February 15, 2018: Clinical and Translational Gastroenterology
journal
journal
43052
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"