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Clinical and Translational Gastroenterology

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https://www.readbyqxmd.com/read/30429464/correction-immune-checkpoint-inhibitor-associated-colitis-and-hepatitis
#1
Haritha G Reddy, Bryan J Schneider, Andrew W Tai
The original version of this Article contained an error in the spelling of colitis in the article title. It was incorrectly spelt as "colits". This has now been corrected in both the PDF and HTML versions of the Article.
November 14, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30429462/correction-a-multicenter-retrospective-study-aiming-to-identify-patients-who-respond-well-to-adsorptive-granulomonocytapheresis-in-moderately-to-severely-active-ulcerative-colitis
#2
Takayuki Yamamoto, Takayuki Iida, Kentaro Ikeya, Masaichi Kato, Ai Matsuura, Satoshi Tamura, Ryosuke Takano, Shinya Tani, Satoshi Osawa, Ken Sugimoto, Takahiro Shimoyama, Hiroyuki Hanai
This Article was originally published under Nature Research's License to Publish, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the Article have been modified accordingly.
November 14, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30420592/prognostic-value-of-micrornas-in-esophageal-carcinoma-a-meta-analysis
#3
Song Gao, Zhi-Ying Zhao, Zhen-Yong Zhang, Yue Zhang, Rong Wu
BACKGROUND: Numerous articles have reported that abnormal expression levels of microRNAs (miRNAs) are related to the survival times of esophageal carcinoma (EC) patients, which contains esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). Nevertheless, there has not been a comprehensive meta-analysis to assess the accurate prognostic value of miRNAs in EC. METHODS: Studies published in English up to April 12, 2018 that evaluated the correlation of the expression levels of miRNAs with overall survival (OS) in EC were identified by online searches in PubMed, EMBASE, Web of Science, and the Cochrane Database of Systematic Reviews performed by two independent authors...
November 13, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30420730/spink1-prss1-ctrc-and-cftr-genotypes-influence-disease-onset-and-clinical-outcomes-in-chronic-pancreatitis
#4
Wen-Bin Zou, Xin-Ying Tang, Dai-Zhan Zhou, Yang-Yang Qian, Liang-Hao Hu, Fei-Fei Yu, Dong Yu, Hao Wu, Shun-Jiang Deng, Jin-Huan Lin, An-Jing Zhao, Zhen-Hua Zhao, Hong-Yu Wu, Jia-Hui Zhu, Wei Qian, Lei Wang, Lei Xin, Min-Jun Wang, Li-Juan Wang, Xue Fang, Lin He, Emmanuelle Masson, David N Cooper, Claude Férec, Zhao-Shen Li, Jian-Min Chen, Zhuan Liao
OBJECTIVES: Rare pathogenic variants in the SPINK1, PRSS1, CTRC, and CFTR genes have been strongly associated with a risk of developing chronic pancreatitis (CP). However, their potential impact on the age of disease onset and clinical outcomes, as well as their potential interactions with environmental risk factors, remain unclear. These issues are addressed here in a large Chinese CP cohort. METHODS: We performed targeted next-generation sequencing of the four CP-associated genes in 1061 Han Chinese CP patients and 1196 controls...
November 12, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30416197/genotype-matters-in-patients-with-acute-on-chronic-liver-failure-due-to-reactivation-of-chronic-hepatitis-b
#5
Yue-Meng Wan, Yu-Hua Li, Zhi-Yuan Xu, Hua-Mei Wu, Xi-Nan Wu, Ying Xu
BACKGROUND: Acute-on-chronic liver failure (ACLF) can be caused by reactivation of chronic hepatitis B virus (HBV) infection (HBV-ACLF). It's unclear whether HBV genotypes affect the clinical and therapeutical outcomes of patients with HBV-ACLF. This study was to investigate the short-term antiviral response and overall survival in HBV-ACLF patients treated by tenofovir or entecavir. METHODS: Seventy-three consecutive patients with HBV-ACLF were stratified into genotype B group (n = 33) and C group (n = 40)...
November 12, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30385752/clinical-heterogeneity-of-immune-dysregulation-polyendocrinopathy-enteropathy-x-linked-syndrome-a-french-multicenter-retrospective-study
#6
R Duclaux-Loras, F Charbit-Henrion, B Neven, J Nowak, S Collardeau-Frachon, C Malcus, P F Ray, D Moshous, J Beltrand, O Goulet, N Cerf-Bensussan, A Lachaux, F Rieux-Laucat, F M Ruemmele
OBJECTIVE: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is an autoimmune disease caused by mutations in the forkhead box protein 3 gene (FOXP3), which encodes a key regulator of immune tolerance. The aim of this study was to describe the clinical heterogeneity of the disease in a national French cohort. METHODS: Multicenter retrospective study of patients diagnosed with IPEX syndrome caused by mutations in FOXP3. RESULTS: Thirty children from 26 families were included...
November 2, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30356052/physical-activity-bmi-and-risk-of-fecal-incontinence-in-the-nurses-health-study
#7
Kyle Staller, Mingyang Song, Francine Grodstein, Catherine A Matthews, William E Whitehead, Braden Kuo, Andrew T Chan, Mary K Townsend
BACKGROUND: Higher body mass index (BMI) and low physical activity have been associated with increased prevalence of fecal incontinence (FI) in cross-sectional studies, but prospective studies examining the role of these factors are lacking. We sought to determine whether BMI and/or physical activity are associated with risk of FI among older women. METHODS: We prospectively examined the association between BMI and physical activity and risk of FI in the Nurses' Health Study among 51,708 women who were free of FI in 2008...
October 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30356041/increasing-dietary-fiber-intake-is-associated-with-a-distinct-esophageal-microbiome
#8
Yael R Nobel, Erik J Snider, Griselda Compres, Daniel E Freedberg, Hossein Khiabanian, Charles J Lightdale, Nora C Toussaint, Julian A Abrams
INTRODUCTION: There is increasing evidence that the microbiome contributes to esophageal disease. Diet, especially fiber and fat intake, is a known potent modifier of the colonic microbiome, but its impact on the esophageal microbiome is not well described. We hypothesized that dietary fiber and fat intake would be associated with a distinct esophageal microbiome. METHODS: We collected esophageal samples from 47 ambulatory patients scheduled to undergo endoscopy who completed a validated food frequency questionnaire quantifying dietary fiber and fat intake...
October 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30353003/long-term-follow-up-of-low-risk-branch-duct-ipmns-of-the-pancreas-watch-for-main-pancreatic-duct-dilatation-and-for-how-long
#9
EDITORIAL
Thiruvengadam Muniraj, Harry R Aslanian
No abstract text is available yet for this article.
October 24, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30323223/vitamins-d-and-k-as-factors-associated-with-osteopathy-in-chronic-pancreatitis-a-prospective-multicentre-study-p-bone-study
#10
Serena Stigliano, Alexander Waldthaler, Emma Martinez-Moneo, Luana Lionetto, Stuart Robinson, Marko Malvik, Aleksandra Hedstrom, Aleksandra Kaczka, Marius Scholdei, Stephan Haas, Maurizio Simmaco, Gianfranco Delle Fave, Matthias Lohr, Peter Simon, Gabriele Capurso
BACKGROUND: Osteopathy is common in patients with chronic pancreatitis (CP), but previous studies carry several limitations. Vitamin K is essential for bone metabolism, but its role in this setting has never been investigated. Our aim is to assess the prevalence of osteoporosis and osteopenia in CP patients, and to investigate the association between osteopathy and CP features and nutritional parameters, especially vitamin D and K levels. METHODS: Multicentre cross-sectional study on CP patients diagnosed according to M-ANNHEIM criteria...
October 15, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30310050/correction-a-multicenter-retrospective-study-aiming-to-identify-patients-who-respond-well-to-adsorptive-granulomonocytapheresis-in-moderately-to-severely-active-ulcerative-colitis
#11
Takayuki Yamamoto, Takayuki Iida, Kentaro Ikeya, Masaichi Kato, Ai Matsuura, Satoshi Tamura, Ryosuke Takano, Shinya Tani, Satoshi Osawa, Ken Sugimoto, Takahiro Shimoyama, Hiroyuki Hanai
A multicenter retrospective study aiming to identify patients who respond well to adsorptive granulomonocytapheresis in moderately to severely active ulcerative colitis.
October 8, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30297816/ghrelin-o-acyltransferase-goat-enzyme-as-a-novel-potential-biomarker-in-gastroenteropancreatic-neuroendocrine-tumors
#12
Aura D Herrera-Martínez, Manuel D Gahete, Rafael Sánchez-Sánchez, Emilia Alors-Perez, Sergio Pedraza-Arevalo, Raquel Serrano-Blanch, Antonio J Martínez-Fuentes, Maria A Gálvez-Moreno, Justo P Castaño, Raúl M Luque
OBJECTIVES: The association between the presence and alterations of the components of the ghrelin system and the development and progression of neuroendocrine tumors (NETs) is still controversial and remains unclear. METHODS: Here, we systematically evaluated the expression levels (by quantitative-PCR) of key ghrelin system components of in gastroenteropancreatic (GEP)-NETs, as compared to non-tumor adjacent (NTA; n = 42) and normal tissues (NT; n = 14)...
October 8, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30297714/correction-the-type-of-bariatric-surgery-impacts-the-risk-of-acute-pancreatitis-a-nationwide-study
#13
Hisham Hussan, Emmanuel Ugbarugba, Kyle Porter, Sabrena Noria, Bradley Needleman, Steven K Clinton, Darwin L Conwell, Somashekar G Krishna
In the original version of this Article, a footnote was missing. The PDF and HTML versions of the Article have now been corrected to include the following: This study was presented as an abstract at the World Congress of Gastroenterology (WCOG) at ACG 2017, Orlando Florida.
October 8, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30293993/first-degree-relatives-of-patients-with-celiac-disease-harbour-an-intestinal-transcriptomic-signature-that-might-protect-them-from-enterocyte-damage
#14
Pragyan Acharya, Rintu Kutum, Rajesh Pandey, Asha Mishra, Rohini Saha, Akshay Munjal, Vineet Ahuja, Mitali Mukerji, Govind K Makharia
INTRODUCTION: Celiac disease (CeD) is an autoimmune enteropathy which affects approximately 0.7% of the global population. While first-degree relatives (FDR) of patients with CeD have a 7.5% risk of developing enteropathy, many remain protected. Therefore, intestinal mucosa of FDR might have protective compensatory mechanisms against immunological injury. We have explored the protective mechanisms that may be active in intestinal mucosa of FDR. METHODS: Intestinal mucosal biopsies (4-5 pieces) from treatment naïve patients with CeD (n = 12), FDR (n = 12) (anti-tTG negative) and controls (n = 12) (anti-tTG negative) were obtained from each individual and subjected to microarray analysis using HT-12-v4 Human Expression BeadChips (Illumina)...
October 8, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30291226/response-to-sachdeva-et-al-brain-fogginess-and-sibo-is-not-a-mirage
#15
LETTER
Satish S C Rao, Siegfried Yu
No abstract text is available yet for this article.
October 5, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30287818/infected-pancreatic-necrosis-due-to-multidrug-resistant-organisms-and-persistent-organ-failure-predict-mortality-in-acute-pancreatitis
#16
Saransh Jain, Soumya Jagannath Mahapatra, Swatantra Gupta, Shalimar, Pramod Kumar Garg
BACKGROUND: Organ failure determines outcome in acute pancreatitis (AP). It is controversial if infected pancreatic necrosis (IPN) is also an independent determinant of mortality. We hypothesized that the predictors of mortality in AP might have changed with advances in management and consequent decline in mortality over the past decades. Our objective was to study the predictors of mortality in patients with AP. METHODS: Consecutive patients with a first episode of AP hospitalized from January 2015 to December 2016 were included in an observational study...
October 5, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30287807/the-use-of-international-classification-of-diseases-codes-to-identify-patients-with-pancreatitis-a-systematic-review-and-meta-analysis-of-diagnostic-accuracy-studies
#17
REVIEW
Amy Y Xiao, Marianne L Tan, Maria N Plana, Dhiraj Yadav, Javier Zamora, Maxim S Petrov
BACKGROUND: Hospital discharge codes are increasingly used in gastroenterology research, but their accuracy in the setting of acute pancreatitis (AP) and chronic pancreatitis (CP), one of the most frequent digestive diseases, has never been assessed systematically. The aim was to conduct a systematic literature review and determine accuracy of diagnostic codes for AP and CP, as well as the effect of covariates. METHODS: Three databases (Pubmed, EMBASE and Scopus) were searched by two independent reviewers for relevant studies that used International Classification of Disease (ICD) codes...
October 4, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30250122/co-occurrence-of-asthma-and-the-inflammatory-bowel-diseases-a-systematic-review-and-meta-analysis
#18
REVIEW
M Ellen Kuenzig, Kirles Bishay, Richard Leigh, Gilaad G Kaplan, Eric I Benchimol
BACKGROUND: Inflammatory bowel diseases (IBD) and asthma share genetic and environmental risk factors. Consequently, several observational studies have explored an association between IBD and asthma. We systematically reviewed and summarized the literature on the co-occurrence of asthma and IBD. METHODS: MEDLINE and EMBASE (to April 2017) were searched to identify observational studies on the association between asthma and IBD. Relative risks (RR) were pooled using random effects models...
September 24, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30250034/association-between-type-2-diabetes-mellitus-hba1c-and-the-risk-for-spontaneous-bacterial-peritonitis-in-patients-with-decompensated-liver-cirrhosis-and-ascites
#19
Tammo L Tergast, Hans Laser, Svetlana Gerbel, Michael P Manns, Markus Cornberg, Benjamin Maasoumy
INTRODUCTION: Type 2 diabetes mellitus (DM) is a frequent comorbidity among patients with liver cirrhosis. However, data regarding the impact of DM on spontaneous bacterial peritonitis (SBP) are quite limited. Our aim was to analyze the impact of DM and HbA1c values on the incidence of SBP and mortality in patients with liver cirrhosis and ascites. METHODS: A number of 475 consecutive patients with liver cirrhosis and ascites were analyzed. Presence of DM as well as HbA1c was assessed at the time of the first paracentesis...
September 24, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/30250026/-brain-fogginess-and-d-lactic-acidosis-probiotics-are-not-the-cause
#20
LETTER
Eamonn M M Quigley, Bruno Pot, Mary Ellen Sanders
No abstract text is available yet for this article.
September 24, 2018: Clinical and Translational Gastroenterology
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