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Clinical and Translational Gastroenterology

Takayuki Yamamoto, Takayuki Iida, Kentaro Ikeya, Masaichi Kato, Ai Matsuura, Satoshi Tamura, Ryosuke Takano, Shinya Tani, Satoshi Osawa, Ken Sugimoto, Takahiro Shimoyama, Hiroyuki Hanai
OBJECTIVES: Adsorptive granulomonocytapheresis (GMA) with the Adacolumn has been introduced as a non-pharmacologic treatment for ulcerative colitis (UC). However, a subset of patients who might respond well to GMA needs to be targeted. This study was conducted at three IBD centers to determine factors affecting the efficacy of GMA in patients with moderately-to-severely active UC. METHODS: From January 2008 to December 2017, a total of 894 active episodes (first attack or relapse) in 593 patients were treated with GMA...
July 6, 2018: Clinical and Translational Gastroenterology
Victoria A L Mosher, Mark G Swain, Jack X Q Pang, Gilaad G Kaplan, Keith A Sharkey, Glenda M MacQueen, Bradley G Goodyear
INTRODUCTION: Behavioral symptoms are commonly reported by patients with primary biliary cholangitis (PBC). In other patient populations, symptoms are commonly associated with hippocampal volume reduction linked to neuroinflammation (inferred from regional iron deposition), as demonstrated by magnetic resonance imaging (MRI). We hypothesized that PBC patients would exhibit reduced volume and increased iron deposition of the hippocampus. METHODS: Seventeen female non-cirrhotic PBC patients and 17 age/gender-matched controls underwent 3-Tesla T1 -weighted MRI and quantitative susceptibility mapping (QSM; an indicator of iron deposition)...
July 6, 2018: Clinical and Translational Gastroenterology
Anton Gies, Katarina Cuk, Petra Schrotz-King, Hermann Brenner
OBJECTIVES: To systematically investigate and directly compare, for the first time, the sample stability of a large number of quantitative fecal immunochemical tests (FITs) at different storage conditions. METHODS: Stool samples were obtained from participants of the German screening colonoscopy program between 2005 and 2010. After an initial FIT-based hemoglobin (Hb) measurement, stool samples were kept frozen at -80 °C until analysis. Twenty randomly selected participants with initial measurements ranging from 10 to 100 μg Hb/g feces were included...
July 6, 2018: Clinical and Translational Gastroenterology
Hideaki Kinugasa, Reiji Higashi, Koji Miyahara, Yuki Moritou, Ken Hirao, Tsuneyoshi Ogawa, Masaki Kunihiro, Masahiro Nakagawa
OBJECTIVE: Conscious sedation for colorectal endoscopic submucosal dissection (ESD) has not been standardized, and there are no studies of sedation for colorectal ESD. METHODS: We conducted a prospective double-blind randomized controlled trial to clarify the usefulness of DEX during colorectal ESD. In total 80 patients with colorectal ESD from April 2016 to May 2017 were assigned to the placebo group or the DEX group (40 cases each). The primary outcome was patient satisfaction (visual analogue scale: VAS)...
July 4, 2018: Clinical and Translational Gastroenterology
Martine A M C Baven-Pronk, Maaike Biewenga, Joanne J van Silfhout, Aad P van den Berg, Henk R van Buuren, Bart J Verwer, Carin M J van Nieuwkerk, Gerd Bouma, Bart van Hoek
BACKGROUND: Few studies with diverging results and a small sample size have compared autoimmune hepatitis (AIH) in the elderly to younger patients. AIM: To unbiasedly investigate the role of age in behaviour and treatment outcome of AIH. METHODS: All patients with probable or definite AIH type 1 in four tertiary academic centres were included in this retrospective-and since 2006 prospective-cohort study. Influence of age on presentation, remission and outcome of AIH were investigated...
July 2, 2018: Clinical and Translational Gastroenterology
Chih-Wen Lin, Yaw-Sen Chen, Chih-Che Lin, Po-Huang Lee, Gin-Ho Lo, Chia-Chang Hsu, Pei-Min Hsieh, Kah Wee Koh, Tsung-Ching Chou, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Yao-Li Chen, Ming-Lung Yu
BACKGROUND: The role of autophagy-related markers as the prognostic factor of post-operative hepatocellular carcinoma (HCC) recurrence remained controversial. METHODS: Overall, 535 consecutive HCC patients undergoing curative resection from 2010 to 2014 were followed and classified with early (ER, <2 years) or late recurrence (LR). Autophagy-related markers, LC3, Beclin-1, and p62 expression was immunohistochemically assessed in HCC and adjacent non-tumor (ANT) tissues...
July 2, 2018: Clinical and Translational Gastroenterology
Chuan-Hao Lin, Rohit Kohli
No abstract text is available yet for this article.
June 29, 2018: Clinical and Translational Gastroenterology
Lung-Yi Mak, Danny Ka-Ho Wong, Ka-Shing Cheung, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen
BACKGROUND: Mac-2-binding protein glycosylation isomer (M2BPGi), a novel serum marker for liver fibrosis, was seldom studied in chronic hepatitis B (CHB). We aimed to evaluate its role on diagnosing significant fibrosis and cirrhosis in treated CHB patients. METHODS: CHB patients treated with nucleos(t)ide analogues (NAs) with baseline liver biopsies and retrievable serum samples were recruited. Paired liver biopsies were performed in patient subgroups at 1 and 3 years...
June 19, 2018: Clinical and Translational Gastroenterology
Laura Rindom Krogsgaard, Lee O 'Brien Andersen, Thor Bech Johannesen, Anne Line Engsbro, Christen Rune Stensvold, Henrik Vedel Nielsen, Peter Bytzer
OBJECTIVE: A low prevalence of intestinal parasites has been identified in individuals with irritable bowel syndrome (IBS), but potential associations with alterations in the bacterial microbiome remain largely unexplored. We aimed to investigate the relationship between parasites and bacteria in individuals with IBS in order to identify potential trans-kingdom microbial characteristics. DESIGN: Stool samples were collected from the Danish background population classified into IBS (n = 119), unspecific gastrointestinal (GI) symptoms (n = 114), and asymptomatic controls (n = 186) based on the Rome III criteria for IBS...
June 19, 2018: Clinical and Translational Gastroenterology
Satish S C Rao, Abdul Rehman, Siegfried Yu, Nicole Martinez de Andino
BACKGROUND: D-lactic acidosis is characterized by brain fogginess (BF) and elevated D-lactate and occurs in short bowel syndrome. Whether it occurs in patients with an intact gut and unexplained gas and bloating is unknown. We aimed to determine if BF, gas and bloating is associated with D-lactic acidosis and small intestinal bacterial overgrowth (SIBO). METHODS: Patients with gas, bloating, BF, intact gut, and negative endoscopic and radiological tests, and those without BF were evaluated...
June 19, 2018: Clinical and Translational Gastroenterology
Sidsel Støy, Thomas Damgaard Sandahl, Anne Louise Hansen, Bent Deleuran, Thomas Vorup-Jensen, Hendrik Vilstrup, Tue Wenzel Kragstrup
OBJECTIVES: During alcoholic hepatitis (AH) monocytes traverse the vascular boundaries and massively invade the liver. In principle, tissue extravasation can be limited through shedding of CD18 integrins from leukocytes, including monocytes. The soluble (s) product sCD18 conceals adhesion receptors on the endothelium, which reduces monocyte extravasation. In AH, monocytes are dysfunctional, but whether this involves their self-generated anti-migration is unknown. Our aim was, therefore, to investigate monocyte CD18 dynamics in AH...
June 15, 2018: Clinical and Translational Gastroenterology
Cheal Wung Huh, Han Hee Lee, Byung-Wook Kim, Joon Sung Kim, Bo-In Lee, Chul-Hyun Lim, Jiyoung Kim
OBJECTIVES: Endoscopic submucosal dissection (ESD) is an effective treatment modality for superficial squamous esophageal neoplasia (SSEN). However, submucosal fibrosis is an important obstacle to successful ESD. The aim of this study was to determine the ESD outcome in relationship to the degree of submucosal fibrosis of SSEN and to identify factors for predicting submucosal fibrosis. METHODS: We retrospectively analyzed endoscopic and pathologic factors related to submucosal fibrosis in 41 patients with SSEN who underwent ESD...
June 15, 2018: Clinical and Translational Gastroenterology
Maria Chiara Petrone, Pietro Magnoni, Ilaria Pergolini, Gabriele Capurso, Mariaemilia Traini, Claudio Doglioni, Alberto Mariani, Stefano Crippa, Paolo Giorgio Arcidiacono
OBJECTIVES: The management of branch-duct IPMN remains controversial due to the relatively low rate of malignant degeneration and the uncertain predictive role of high-risk stigmata (HRS) and worrisome features (WFs) identified by the 2012 International Consensus Guidelines. Our aim was to evaluate the evolution of originally low-risk (Fukuoka-negative) BD-IPMNs during a long follow-up period in order to determine whether the appearance of any clinical or morphological variables may be independently associated with the development of malignancy over time...
June 13, 2018: Clinical and Translational Gastroenterology
Sarah Moretti, Simona Mrakic-Sposta, Leda Roncoroni, Alessandra Vezzoli, Cinzia Dellanoce, Erika Monguzzi, Federica Branchi, Francesca Ferretti, Vincenza Lombardo, Luisa Doneda, Alice Scricciolo, Luca Elli
INTRODUCTION: High levels of reactive oxygen species (ROS) and impaired antioxidant defense systems lead to oxidative stress (OxS) and tissue injury in different intestinal and extra intestinal conditions, including celiac disease (CD). The aim of the present study was to investigate the role and potential use of ROS and other biomarkers of OxS in the clinical management of CD. METHODS: We collected duodenal specimens and blood samples from naïve patients (N-CD), patients on a gluten free diet (GFD) including responders (CD-GFD) and non-responders (NRCD)...
June 8, 2018: Clinical and Translational Gastroenterology
Yash Choksi, Michael F Vaezi
Analysis of the esophageal microbiome remains a new field of research. Two hypothesis-generating papers published in the current issue of the Journal go beyond characterizing the esophageal microbiome in Barrett's esophagus or eosinophilic esophagitis (EoE). Snider et al. suggest that the salivary microbiome can be used as a screening tool for Barrett's esophagus, and Arias et al. demonstrates abnormal expression of Toll-like receptors and innate immune effector proteins in patients with active EoE. We discuss these findings, raise fundamental questions about microbiome studies, and offer ideas for future studies...
May 29, 2018: Clinical and Translational Gastroenterology
Kec Bouter, G J Bakker, E Levin, A V Hartstra, R S Kootte, S D Udayappan, S Katiraei, L Bahler, P W Gilijamse, V Tremaroli, M Stahlman, F Holleman, N A W van Riel, H J Verberne, J A Romijn, G M Dallinga-Thie, M J Serlie, M T Ackermans, E M Kemper, K Willems van Dijk, F Backhed, A K Groen, M Nieuwdorp
BACKGROUND: Gut microbiota-derived short-chain fatty acids (SCFAs) have been associated with beneficial metabolic effects. However, the direct effect of oral butyrate on metabolic parameters in humans has never been studied. In this first in men pilot study, we thus treated both lean and metabolic syndrome male subjects with oral sodium butyrate and investigated the effect on metabolism. METHODS: Healthy lean males (n = 9) and metabolic syndrome males (n = 10) were treated with oral 4 g of sodium butyrate daily for 4 weeks...
May 25, 2018: Clinical and Translational Gastroenterology
Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Sadahisa Ogasawara, Yoshihiko Ooka, Eiichiro Suzuki, Tetsuhiro Chiba, Naoya Kato
OBJECTIVE: To examine the effect of hemodynamic assessment of the left gastric vein (LGV) as a noninvasive test to diagnose esophageal varices (EV) in cirrhosis patients. METHODS: This cross-sectional study consisted of 229 cirrhosis patients (62.7 ± 11.8 years; Child-Pugh score 5-14). One hundred fifty-four patients had EV (67.2%; small, 53; medium, 71; large, 30). All patients underwent a blood test and Doppler ultrasound followed by upper gastrointestinal endoscopy on the same day...
May 25, 2018: Clinical and Translational Gastroenterology
Prashanthi N Thota
Aspirin use is associated with reduction of esophageal adenocarcinoma but it is not known if it does so by preventing the development of Barrett's esophagus or by reducing neoplastic progression in patients with Barrett's esophagus. There is sparse literature to support the former assumption especially in women. This study by Jovani et al. based on Nurses' Health Study reports 27% lower risk of Barrett's esophagus among women using aspirin. The protective effect seems to increase with higher frequency and longer duration of aspirin use...
May 2, 2018: Clinical and Translational Gastroenterology
Oisín Bugter, Manon C W Spaander, Marco J Bruno, Robert J Baatenburg de Jong, Arjen Amelink, Dominic J Robinson
INTRODUCTION: Esophageal cancer is an increasingly common type of neoplasm with a very poor prognosis. This prognosis could improve with more early tumor detection. We have previously shown that we can use an optical spectroscopy to detect field cancerization in the buccal mucosa of patients with laryngeal cancer. The aim of this prospective study was to investigate whether we could detect field cancerization of buccal mucosa of patients with esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)...
April 30, 2018: Clinical and Translational Gastroenterology
Katrin Bankov, Claudia Döring, Markus Schneider, Sylvia Hartmann, Ria Winkelmann, Joerg G Albert, Wolf Otto Bechstein, Stefan Zeuzem, Martin Leo Hansmann, Jan Peveling-Oberhag, Dirk Walter
BACKGROUND: Definite diagnosis and therapeutic management of cholangiocarcinoma (CCA) remains a challenge. The aim of the current study was to investigate feasibility and potential impact on clinical management of targeted sequencing of intraductal biopsies. METHODS: Intraductal biopsies with suspicious findings from 16 patients with CCA in later clinical course were analyzed with targeted sequencing including tumor and control benign tissue (n = 55 samples)...
April 30, 2018: Clinical and Translational Gastroenterology
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