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Clinical and Translational Gastroenterology

Hisham Hussan, Emmanuel Ugbarugba, Kyle Porter, Sabrena Noria, Bradley Needleman, Steven K Clinton, Darwin L Conwell, Somashekar G Krishna
OBJECTIVE: We investigated whether vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgery (RYGB) have a differential impact on post-operative risk of acute pancreatitis (AP). METHODS: This retrospective study uses the 2012-2014 National Readmission Database. We compared morbidly obese patients who underwent VSG (n = 205,251), RYGB (n = 169,973), and hernia repair (HR) control (n = 16,845). Our main outcome was rates of AP within 6 months post- vs...
September 12, 2018: Clinical and Translational Gastroenterology
Weibin Wang, Lai Xu, Yu Yang, LiangBo Dong, BangBo Zhao, Jun Lu, Taiping Zhang, Yupei Zhao
BACKGROUND: Previous study, using immunoblotting with IgG and membrane proteins, identified prohibitin (PHB) as a potential immunogenic membrane antigen. Now, investigate PHB expression and biological functions in pancreatic cancer. METHODS: PHB expression was analysed in PDAC cell lines, normal pancreas tissues, cancer tissues, PDAC patient sera and healthy volunteer sera using QRT-PCR, Western blotting, IHC, and ELISA, and a survival analysis and a COX regression analysis were performed...
September 6, 2018: Clinical and Translational Gastroenterology
Christine Yu, Samuel Skootsky, Mark Grossman, Omai B Garner, Anna Betlachin, Eric Esrailian, Daniel W Hommes, Folasade P May
INTRODUCTION: Colorectal cancer (CRC) is a common but largely preventable disease with suboptimal screening rates despite national guidelines to screen individuals age 50-75. Single-component interventions aimed to improve screening uptake only modestly improve rates; data suggest that multi-modal approaches may be more effective. METHODS: We designed, implemented, and evaluated the impact of a multi-modal intervention on CRC screening uptake among unscreened patients in a large managed care population...
September 4, 2018: Clinical and Translational Gastroenterology
Lindsay A Sobotka, Syed G Husain, Somashekar G Krishna, Alice Hinton, Ravi Pavurula, Darwin L Conwell, Cheng Zhang
INTRODUCTION: The Center for Medicare and Medicaid Services established 30-day readmission rate as a key metric in measuring high-value, cost-conscious care; therefore, our aim is to develop a risk score for 30-day readmission in ulcerative colitis (UC) patients undergoing colectomy or proctectomy. METHODS: This study used data from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) participant user file (2011-2015). Patients with UC undergoing colectomy or proctectomy were identified using ICD-9, 10, and CPT codes...
August 15, 2018: Clinical and Translational Gastroenterology
Marco Senzolo, Nicoletta Riva, Francesco Dentali, Kryssia Rodriguez-Castro, Maria Teresa Sartori, Soo-Mee Bang, Ida Martinelli, Sam Schulman, Adriano Alatri, Jan Beyer-Westendorf, Matteo Nicola Dario Di Minno, Walter Ageno
INTRODUCTION: Little is known about the long-term outcome of cirrhotic patients with splanchnic vein thrombosis (SVT). This prospective cohort study aimed to describe the clinical presentation, bleeding incidence, thrombotic events, and mortality in patients with SVT associated with cirrhosis. METHODS: Among 604 consecutive patients with SVT enrolled over 2 years, 149 had cirrhosis. Major bleeding, thrombotic events, and all-cause mortality were recorded during a 2-year follow-up...
August 15, 2018: Clinical and Translational Gastroenterology
Margaret E MacPhail, Samuel A Main, William W Tippins, Andrew W Sullivan, Douglas K Rex
BACKGROUND: Efficiency is an important aspect of endoscopic practice that has received limited study. We evaluated the impact of scribing electronic pre-procedure history and physical examinations, and electronic procedure reports on endoscopist efficiency. METHODS: We used a stopwatch to measure the time between the procedures (scope out to scope in), pre-procedure patient assessment time, and procedure report generation time for 180 consecutive procedures performed by a single endoscopist with or without a scribe for recording history and physical and procedure reports...
August 10, 2018: Clinical and Translational Gastroenterology
Maria Chiara Petrone, Pietro Magnoni, Ilaria Pergolini, Gabriele Capurso, Mariaemilia Traini, Claudio Doglioni, Alberto Mariani, Stefano Crippa, Paolo Giorgio Arcidiacono
In the HTML version of this paper Pietro Magnoni was incorrectly tagged as the corresponding author. The corresponding author should have been Maria Chiara Petrone. This has now been corrected in the HTML version of the paper.
August 1, 2018: Clinical and Translational Gastroenterology
Michael G Kattah, Jeffrey M Milush, Trevor Burt, Robert P McCabe, Michael I Whang, Averil Ma, Uma Mahadevan
The original version of this article contained an error in Fig. 2, in which part of the text in the legend was omitted. This has now been corrected in the PDF and HTML versions of the paper.Furthermore, the figure legends were missing for the Supplementary figure files. The HTML has now been updated to include a corrected version of the Supplementary Information.
July 31, 2018: Clinical and Translational Gastroenterology
Sidsel Støy, Thomas Damgaard Sandahl, Anne Louise Hansen, Bent Deleuran, Thomas Vorup-Jensen, Hendrik Vilstrup, Tue Wenzel Kragstrup
The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information.
July 24, 2018: Clinical and Translational Gastroenterology
Takayuki Yamamoto, Takayuki Iida, Kentaro Ikeya, Masaichi Kato, Ai Matsuura, Satoshi Tamura, Ryosuke Takano, Shinya Tani, Satoshi Osawa, Ken Sugimoto, Takahiro Shimoyama, Hiroyuki Hanai
OBJECTIVES: Adsorptive granulomonocytapheresis (GMA) with the Adacolumn has been introduced as a non-pharmacologic treatment for ulcerative colitis (UC). However, a subset of patients who might respond well to GMA needs to be targeted. This study was conducted at three IBD centers to determine factors affecting the efficacy of GMA in patients with moderately-to-severely active UC. METHODS: From January 2008 to December 2017, a total of 894 active episodes (first attack or relapse) in 593 patients were treated with GMA...
July 6, 2018: Clinical and Translational Gastroenterology
Victoria A L Mosher, Mark G Swain, Jack X Q Pang, Gilaad G Kaplan, Keith A Sharkey, Glenda M MacQueen, Bradley G Goodyear
INTRODUCTION: Behavioral symptoms are commonly reported by patients with primary biliary cholangitis (PBC). In other patient populations, symptoms are commonly associated with hippocampal volume reduction linked to neuroinflammation (inferred from regional iron deposition), as demonstrated by magnetic resonance imaging (MRI). We hypothesized that PBC patients would exhibit reduced volume and increased iron deposition of the hippocampus. METHODS: Seventeen female non-cirrhotic PBC patients and 17 age/gender-matched controls underwent 3-Tesla T1 -weighted MRI and quantitative susceptibility mapping (QSM; an indicator of iron deposition)...
July 6, 2018: Clinical and Translational Gastroenterology
Anton Gies, Katarina Cuk, Petra Schrotz-King, Hermann Brenner
OBJECTIVES: To systematically investigate and directly compare, for the first time, the sample stability of a large number of quantitative fecal immunochemical tests (FITs) at different storage conditions. METHODS: Stool samples were obtained from participants of the German screening colonoscopy program between 2005 and 2010. After an initial FIT-based hemoglobin (Hb) measurement, stool samples were kept frozen at -80 °C until analysis. Twenty randomly selected participants with initial measurements ranging from 10 to 100 μg Hb/g feces were included...
July 6, 2018: Clinical and Translational Gastroenterology
Hideaki Kinugasa, Reiji Higashi, Koji Miyahara, Yuki Moritou, Ken Hirao, Tsuneyoshi Ogawa, Masaki Kunihiro, Masahiro Nakagawa
OBJECTIVE: Conscious sedation for colorectal endoscopic submucosal dissection (ESD) has not been standardized, and there are no studies of sedation for colorectal ESD. METHODS: We conducted a prospective double-blind randomized controlled trial to clarify the usefulness of DEX during colorectal ESD. In total 80 patients with colorectal ESD from April 2016 to May 2017 were assigned to the placebo group or the DEX group (40 cases each). The primary outcome was patient satisfaction (visual analogue scale: VAS)...
July 4, 2018: Clinical and Translational Gastroenterology
Martine A M C Baven-Pronk, Maaike Biewenga, Joanne J van Silfhout, Aad P van den Berg, Henk R van Buuren, Bart J Verwer, Carin M J van Nieuwkerk, Gerd Bouma, Bart van Hoek
BACKGROUND: Few studies with diverging results and a small sample size have compared autoimmune hepatitis (AIH) in the elderly to younger patients. AIM: To unbiasedly investigate the role of age in behaviour and treatment outcome of AIH. METHODS: All patients with probable or definite AIH type 1 in four tertiary academic centres were included in this retrospective-and since 2006 prospective-cohort study. Influence of age on presentation, remission and outcome of AIH were investigated...
July 2, 2018: Clinical and Translational Gastroenterology
Chih-Wen Lin, Yaw-Sen Chen, Chih-Che Lin, Po-Huang Lee, Gin-Ho Lo, Chia-Chang Hsu, Pei-Min Hsieh, Kah Wee Koh, Tsung-Ching Chou, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Yao-Li Chen, Ming-Lung Yu
BACKGROUND: The role of autophagy-related markers as the prognostic factor of post-operative hepatocellular carcinoma (HCC) recurrence remained controversial. METHODS: Overall, 535 consecutive HCC patients undergoing curative resection from 2010 to 2014 were followed and classified with early (ER, <2 years) or late recurrence (LR). Autophagy-related markers, LC3, Beclin-1, and p62 expression was immunohistochemically assessed in HCC and adjacent non-tumor (ANT) tissues...
July 2, 2018: Clinical and Translational Gastroenterology
Chuan-Hao Lin, Rohit Kohli
No abstract text is available yet for this article.
June 29, 2018: Clinical and Translational Gastroenterology
Lung-Yi Mak, Danny Ka-Ho Wong, Ka-Shing Cheung, Wai-Kay Seto, Ching-Lung Lai, Man-Fung Yuen
BACKGROUND: Mac-2-binding protein glycosylation isomer (M2BPGi), a novel serum marker for liver fibrosis, was seldom studied in chronic hepatitis B (CHB). We aimed to evaluate its role on diagnosing significant fibrosis and cirrhosis in treated CHB patients. METHODS: CHB patients treated with nucleos(t)ide analogues (NAs) with baseline liver biopsies and retrievable serum samples were recruited. Paired liver biopsies were performed in patient subgroups at 1 and 3 years...
June 19, 2018: Clinical and Translational Gastroenterology
Laura Rindom Krogsgaard, Lee O 'Brien Andersen, Thor Bech Johannesen, Anne Line Engsbro, Christen Rune Stensvold, Henrik Vedel Nielsen, Peter Bytzer
OBJECTIVE: A low prevalence of intestinal parasites has been identified in individuals with irritable bowel syndrome (IBS), but potential associations with alterations in the bacterial microbiome remain largely unexplored. We aimed to investigate the relationship between parasites and bacteria in individuals with IBS in order to identify potential trans-kingdom microbial characteristics. DESIGN: Stool samples were collected from the Danish background population classified into IBS (n = 119), unspecific gastrointestinal (GI) symptoms (n = 114), and asymptomatic controls (n = 186) based on the Rome III criteria for IBS...
June 19, 2018: Clinical and Translational Gastroenterology
Satish S C Rao, Abdul Rehman, Siegfried Yu, Nicole Martinez de Andino
BACKGROUND: D-lactic acidosis is characterized by brain fogginess (BF) and elevated D-lactate and occurs in short bowel syndrome. Whether it occurs in patients with an intact gut and unexplained gas and bloating is unknown. We aimed to determine if BF, gas and bloating is associated with D-lactic acidosis and small intestinal bacterial overgrowth (SIBO). METHODS: Patients with gas, bloating, BF, intact gut, and negative endoscopic and radiological tests, and those without BF were evaluated...
June 19, 2018: Clinical and Translational Gastroenterology
Sidsel Støy, Thomas Damgaard Sandahl, Anne Louise Hansen, Bent Deleuran, Thomas Vorup-Jensen, Hendrik Vilstrup, Tue Wenzel Kragstrup
OBJECTIVES: During alcoholic hepatitis (AH) monocytes traverse the vascular boundaries and massively invade the liver. In principle, tissue extravasation can be limited through shedding of CD18 integrins from leukocytes, including monocytes. The soluble (s) product sCD18 conceals adhesion receptors on the endothelium, which reduces monocyte extravasation. In AH, monocytes are dysfunctional, but whether this involves their self-generated anti-migration is unknown. Our aim was, therefore, to investigate monocyte CD18 dynamics in AH...
June 15, 2018: Clinical and Translational Gastroenterology
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