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Clinical and Translational Gastroenterology

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https://www.readbyqxmd.com/read/29095427/centrally-determined-standardization-of-flow-cytometry-methods-reduces-interlaboratory-variation-in-a-prospective-multicenter-study
#1
Liset Westera, Tanja van Viegen, Jenny Jeyarajah, Azar Azad, Janine Bilsborough, Gijs R van den Brink, Jonathan Cremer, Silvio Danese, Geert D'Haens, Lars Eckmann, William Faubion, Melissa Filice, Hannelie Korf, Dermot McGovern, Julian Panes, Azucena Salas, William J Sandborn, Mark S Silverberg, Michelle I Smith, Severine Vermeire, Stefania Vetrano, Lisa M Shackelton, Larry Stitt, Vipul Jairath, Barrett G Levesque, David M Spencer, Brian G Feagan, Niels Vande Casteele
OBJECTIVES: Flow cytometry (FC) aids in characterization of cellular and molecular factors involved in pathologic immune responses. Although FC has potential to facilitate early drug development in inflammatory bowel disease, interlaboratory variability limits its use in multicenter trials. Standardization of methods may address this limitation. We compared variability in FC-aided quantitation of T-cell responses across international laboratories using three analytical strategies. METHODS: Peripheral blood mononuclear cells (PBMCs) were isolated from three healthy donors, stimulated with phorbol 12-myristate 13-acetate and ionomycin at a central laboratory, fixed, frozen, and shipped to seven international laboratories...
November 2, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29072674/comparison-of-impedance-and-pepsin-detection-in-the-laryngeal-mucosa-to-determine-impedance-values-that-indicate-pathological-laryngopharyngeal-reflux
#2
Martin Formánek, Debora Jančatová, Pavel Komínek, Radoslava Tomanová, Karol Zeleník
OBJECTIVE: Recently, a 24-h impedance was used to detect laryngopharyngeal reflux (LPR). However, not every case of LPR is pathological. Thus, pathological pharyngeal impedance values need to be clearly established to diagnose pathological LPR. The aim of our study was to establish pathological 24-h pharyngoesophageal impedance/pH values for the diagnosis of LPR. METHODS: The study was conducted in a tertiary care setting. A total of 30 patients who were referred to microlaryngoscopy for a laryngeal pathology that might be caused by LPR were included in this prospective study...
October 26, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29072673/seven-year-treatment-outcome-of-entecavir-in-a-real-world-cohort-effects-on-clinical-parameters-hbsag-and-hbcrag-levels
#3
Yuk-Fai Lam, Wai-Kay Seto, Danny Wong, Ka-Shing Cheung, James Fung, Lung-Yi Mak, John Yuen, Chun-Kong Chong, Ching-Lung Lai, Man-Fung Yuen
OBJECTIVES: We aimed to determine the levels of alanine aminotransferase (ALT), hepatitis B virus DNA (HBV DNA), HBsAg, and a novel viral marker (hepatitis B core-related antigen (HBcrAg)); hepatitis B e antigen (HBeAg) seroconversion and drug resistance rates after 7 years of entecavir treatment in chronic hepatitis B (CHB) patients. METHODS: Two hundred and twenty-two Chinese CHB patients on continuous entecavir treatment were recruited. Serologic, virologic, biochemical outcomes, and the occurrence of entecavir signature mutations were determined...
October 26, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29048416/increased-frequency-of-kras-mutations-in-african-americans-compared-with-caucasians-in-sporadic-colorectal-cancer
#4
Jonas J Staudacher, Cemal Yazici, Vadim Bul, Joseph Zeidan, Ahmer Khalid, Yinglin Xia, Nancy Krett, Barbara Jung
OBJECTIVES: The basis for over-representation of colorectal cancer (CRC) in African-American (AA) populations compared with Caucasians are multifactorial and complex. Understanding the mechanisms for this racial disparity is critical for delivery of better care. Several studies have investigated sporadic CRC for differences in somatic mutations between AAs and Caucasians, but owing to small study sizes and conflicting results to date, no definitive conclusions have been reached. METHODS: Here, we present the first systematic literature review and meta-analysis investigating the mutational differences in sporadic CRC between AAs and Caucasians focused on frequent driver mutations (APC,TP53, KRAS,PI3CA, FBXW7,SMAD4, and BRAF)...
October 19, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29022926/erratum-transmembrane-tnf-%C3%AE-density-but-not-soluble-tnf-%C3%AE-level-is-associated-with-primary-response-to-infliximab-in-inflammatory-bowel-disease
#5
Azade Amini Kadijani, Hamid Asadzadeh Aghdaei, Dario Sorrentino, Alireza Mirzaei, Shabnam Shahrokh, Hedieh Balaii, Vu Q Nguyen, Jessica L Mays, Mohammad Reza Zali
This corrects the article DOI: 10.1038/ctg.2017.44.
October 12, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28981082/a-new-preoperative-prognostic-system-combining-crp-and-ca199-for-patients-with-intrahepatic-cholangiocarcinoma
#6
Bo-Hao Zheng, Liu-Xiao Yang, Qi-Man Sun, Hong-Kai Fan, Men Duan, Jie-Yi Shi, Xiao-Ying Wang, Jian Zhou, Jia Fan, Zheng-Yao Ma, Qiang Gao
OBJECTIVES: In this study, we aimed at investigating the preoperatively available prognostic factors for intrahepatic cholangiocarcinoma (ICC) patients and proposing a new preoperative prognostic scoring system for ICC. METHODS: A total of 246 consecutive ICC patients who underwent curative hepatectomy were enrolled retrospectively and were randomly divided into training (n=164) and validation cohorts (n=82) at a ratio of 2:1. The prognostic factors were investigated in both cohorts using multivariate Cox's proportional hazards regression model...
October 5, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28981081/influence-of-gaba-b-agonist-baclofen-on-capsaicin-induced-excitation-of-secondary-peristalsis-in-humans
#7
Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, Chih-Hsun Yi, Chien-Lin Chen
OBJECTIVES: Esophageal instillation of capsaicin enhances secondary peristalsis, but the γ-aminobutyric acid receptor type B (GABA-B) agonist baclofen inhibits secondary peristalsis. This study aimed to investigate whether baclofen could influence heartburn perception and secondary peristalsis subsequent to capsaicin infusion in healthy adults. METHODS: Secondary peristalsis was performed by slow and rapid mid-esophagus air injections in 15 healthy subjects. Two different sessions including esophageal infusion of capsaicin-containing red pepper sauce (0...
October 5, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28981080/improvement-in-esophageal-distensibility-in-response-to-medical-and-diet-therapy-in-eosinophilic-esophagitis
#8
Dustin A Carlson, Ikuo Hirano, Angelika Zalewski, Nirmala Gonsalves, Zhiyue Lin, John E Pandolfino
OBJECTIVES: We aimed to evaluate the effect of medical and diet therapies on esophageal distensibility assessed using the functional lumen imaging probe (FLIP) and the association of changes in esophageal distensibility with clinical outcomes in eosinophilic esophagitis (EoE). METHODS: Patients with EoE were evaluated with FLIP during endoscopy at baseline and following therapy without interval dilatation. Evaluation also included a validated patient-reported outcome (PRO; a positive PRO was considered at a 30% score improvement), mucosal biopsies, and scoring of endoscopic features of EoE...
October 5, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28914262/transmembrane-tnf-%C3%AE-density-but-not-soluble-tnf-%C3%AE-level-is-associated-with-primary-response-to-infliximab-in-inflammatory-bowel-disease
#9
Azade Amini Kadijani, Hamid Asadzadeh Aghdaei, Dario Sorrentino, Alireza Mirzaei, Shabnam Shahrokh, Hedieh Balaii, Vu Q Nguyen, Jessica L Mays, Mohammad Reza Zali
OBJECTIVES: Anti-tumor necrosis factor (TNF)-α agents like Infliximab (IFX) are effective in the treatment of inflammatory bowel diseases (IBDs) and are widely used. However, a considerable number of patients do not respond or lose response to this therapy. Preliminary evidence suggests that transmembrane TNF-α (tmTNF-α) might be linked to response to IFX by promoting reverse signaling-induced apoptosis in inflammatory cells. The main aim of this study was the evaluation of this hypothesis in primary IFX non-responders...
September 14, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28858292/endoscopic-drainage-of-50-of-liver-in-malignant-hilar-biliary-obstruction-using-metallic-or-fenestrated-plastic-stents
#10
Tossapol Kerdsirichairat, Mustafa A Arain, Rajeev Attam, Brooke Glessing, Yan Bakman, Stuart K Amateau, Martin L Freeman
OBJECTIVES: Endoscopic drainage of complex hilar tumors has generally resulted in poor outcomes. Drainage of >50% of liver volume has been proposed as optimal, but not evaluated using long multifenestrated plastic stents (MFPS) or self-expanding metal stents (SEMS). We evaluated outcomes of endoscopic drainage of malignant hilar strictures using optimal strategy and stents, and determined factors associated with stent patency, survival, and complications. METHODS: Cross-sectional study was conducted at an academic center over 5 years...
August 31, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28858291/epidemiology-and-natural-history-of-primary-biliary-cholangitis-in-the-chinese-a-territory-based-study-in-hong-kong-between-2000-and-2015
#11
Ka-Shing Cheung, Wai-Kay Seto, James Fung, Ching-Lung Lai, Man-Fung Yuen
OBJECTIVES: Studies on the epidemiology of primary biliary cholangitis (PBC) in the Chinese population are lacking. We aimed to determine the epidemiology of PBC in Hong Kong (HK) with a population of 7.3 million. METHODS: We retrieved data from the electronic database of the HK Hospital Authority, the only public healthcare provider in Hong Kong. PBC cases between 2000 and 2015 were identified by International Classification of Diseases (ICD)-9 code. We estimated the age-/sex-adjusted incidence rate and prevalence of PBC, and analyzed the adverse outcomes (hepatocellular carcinoma (HCC), liver transplantation, and death)...
August 31, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28817113/clinical-and-histologic-mimickers-of-celiac-disease
#12
REVIEW
Amrit K Kamboj, Amy S Oxentenko
Celiac disease is an autoimmune disorder of the small bowel, classically associated with diarrhea, abdominal pain, and malabsorption. The diagnosis of celiac disease is made when there are compatible clinical features, supportive serologic markers, representative histology from the small bowel, and response to a gluten-free diet. Histologic findings associated with celiac disease include intraepithelial lymphocytosis, crypt hyperplasia, villous atrophy, and a chronic inflammatory cell infiltrate in the lamina propria...
August 17, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28796231/impact-of-fecal-hb-levels-on-advanced-neoplasia-detection-and-the-diagnostic-miss-rate-for-colorectal-cancer-screening-in-high-risk-vs-average-risk-subjects-a-multi-center-study
#13
Satimai Aniwan, Thawee Ratanachu-Ek, Supot Pongprasobchai, Julajak Limsrivilai, Ong-Ard Praisontarangkul, Pises Pisespongsa, Pisaln Mairiang, Apichat Sangchan, Jaksin Sottisuporn, Naruemon Wisedopas, Pinit Kullavanijaya, Rungsun Rerknimitr
OBJECTIVES: The Asia-Pacific Colorectal Screening (APCS) scoring system was developed to identify high-risk subjects for advanced neoplasia. However, the appropriate fecal immunochemical test (FIT) cutoff for high-risk population may be different from that of average-risk population. We aimed to evaluate the FIT performance at different cutoffs in high-risk subjects undergoing colorectal cancer (CRC) screening. METHODS: We prospectively enrolled asymptomatic subjects aged 50-75 years...
August 10, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28771242/pancreatic-and-intestinal-function-post-roux-en-y-gastric-bypass-surgery-for-obesity
#14
Stephen J D O'Keefe, Tina Rakitt, Junhai Ou, Ihab I El Hajj, Elizabeth Blaney, Kishore Vipperla, Jens-Jules Holst, Jens Rehlfeld
OBJECTIVES: Despite the fact that the most effective treatment for morbid obesity today is gastric bypass surgery, some patients develop life-threatening nutritional complications associated with their weight loss. METHODS: Here we examine the influence of the altered anatomy and digestive physiology on pancreatic secretion and fat absorption. Thirteen post Roux-en-Y gastric bypass (RYGB) patients who had lost >100 lbs in the first year following surgery and who gave variable histories of gastrointestinal (GI) dysfunction, were selected for study...
August 3, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28771241/efficacy-and-safety-of-endoscopic-resection-followed-by-chemoradiotherapy-for-superficial-esophageal-squamous-cell-carcinoma-a-retrospective-study
#15
Kenta Hamada, Ryu Ishihara, Yasushi Yamasaki, Noboru Hanaoka, Sachiko Yamamoto, Masamichi Arao, Sho Suzuki, Taro Iwatsubo, Minoru Kato, Yusuke Tonai, Satoki Shichijo, Noriko Matsuura, Hiroko Nakahira, Takashi Kanesaka, Tomofumi Akasaka, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Hiroyasu Iishi, Naoyuki Kanayama, Takero Hirata, Yoshifumi Kawaguchi, Koji Konishi, Teruki Teshima
OBJECTIVES: The reported 1- and 3-year overall survival rates after esophagectomy for stage I superficial esophageal squamous cell carcinoma (SESCC) are 95-97% and 86%, and those after definitive chemoradiotherapy (CRT) are 98% and 89%, respectively. This study was performed to elucidate the efficacy and safety of another treatment option for SESCC: endoscopic resection (ER) followed by CRT. METHODS: We retrospectively reviewed the overall survival, recurrence, and grade ≥3 adverse events of consecutive patients who refused esophagectomy and underwent ER followed by CRT for SESCC from 1 January 2006 to 31 December 2012...
August 3, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28771240/selecting-a-cut-off-for-colorectal-cancer-screening-with-a-fecal-immunochemical-test
#16
Hermann Brenner, Simone Werner
OBJECTIVES: Fecal immunochemical tests (FITs) for hemoglobin (Hb) are increasingly used for colorectal cancer (CRC) screening. However, cut-offs for defining test positivity are varying widely. We aimed to evaluate the impact of cut-off selection on key indicators of diagnostic performance in a true screening setting. METHODS: We evaluated diagnostic performance of FOB Gold, a widely used quantitative FIT, for detecting advanced neoplasms (AN) across a wide range of possible cut-offs among 1822 participants of screening colonoscopy aged 50-79 years in Germany...
August 3, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28749455/primary-biliary-cholangitis-alters-functional-connections-of-the-brain-s-deep-gray-matter
#17
Victoria A L Mosher, Mark G Swain, Jack X Q Pang, Gilaad G Kaplan, Keith A Sharkey, Glenda M MacQueen, Bradley G Goodyear
OBJECTIVES: Fatigue, itch, depressed mood, and cognitive impairment significantly impact the quality of life of many patients with primary biliary cholangitis (PBC). Previous neuroimaging studies of non-hepatic diseases suggest that these symptoms are often associated with dysfunction of deep gray matter brain regions. We used resting-state functional magnetic resonance imaging (rsfMRI) to determine whether PBC patients exhibit altered functional connections of deep gray matter. METHODS: Twenty female non-cirrhotic PBC patients and 21 age/gender-matched controls underwent rsfMRI...
July 27, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28749454/the-association-of-low-penetrance-variants-in-dna-repair-genes-with-colorectal-cancer-a-systematic-review-and-meta-analysis
#18
Nikhil Aggarwal, Neil D Donald, Salim Malik, Subothini S Selvendran, Mark Jw McPhail, Kevin J Monahan
OBJECTIVES: Approximately 35% of colorectal cancer (CRC) risk is attributable to heritable factors known hereditary syndromes, accounting for 6%. The remainder may be due to lower penetrance polymorphisms particularly of DNA repair genes. DNA repair pathways, including base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), direct reversal repair (DRR), and double-strand break repair are complex, evolutionarily conserved, and critical in carcinogenesis. Germline mutations in these genes are associated with high-penetrance CRC syndromes such as Lynch syndrome...
July 27, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28749453/mindfulness-based-stress-reduction-therapy-improves-patient-and-caregiver-reported-outcomes-in-cirrhosis
#19
Jasmohan S Bajaj, Michael Ellwood, Timothy Ainger, Thomas Burroughs, Andrew Fagan, Edith A Gavis, Douglas M Heuman, Michael Fuchs, Binu John, James B Wade
OBJECTIVES: Patient-reported outcomes such as health-related quality of life (HRQOL) are impaired in cirrhosis due to under-treated mood and sleep disorders, which can adversely impact their caregivers. Mindfulness-based stress reduction (MBSR) can improve patient-reported outcomes (PRO) in non-cirrhotic patients but their impact in cirrhosis is unclear. To evaluate the effect of MBSR and supportive group therapy on mood, sleep and HRQOL in cirrhotic patients and their caregivers. METHODS: Cirrhotic outpatients with mild depression (Beck Depression Inventory (BDI)>14) on screening with an adult caregiver were enrolled...
July 27, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28703786/fistulizing-crohn-s-disease
#20
Michael Scharl, Gerhard Rogler, Luc Biedermann
Fistulas still represent one of the most important complications in patients with Crohn's disease (CD). At least one third of CD patients suffer from fistulas during their disease course and amongst them longstanding remission of complex fistulas occurs only in about one third. So far, fistula pathogenesis is only partially understood. From a histopathological view, a fistula is a tube covered by flat epithelial cells. Current research suggests that the driving force for fistula development is epithelial-to-mesenchymal transition (EMT)...
July 13, 2017: Clinical and Translational Gastroenterology
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