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Experimental and Therapeutic Medicine

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https://www.readbyqxmd.com/read/29043004/efficacy-of-perineural-dexamethasone-with-ropivacaine-in-adductor-canal-block-for-post-operative-analgesia-in-patients-undergoing-total-knee-arthroplasty-a-randomized-controlled-trial
#1
Cun-Jin Wang, Feng-Yun Long, Liu-Qing Yang, You-Jing Shen, Fang Guo, Tian-Feng Huang, Ju Gao
Adductor canal block (ACB) is an effective analgesic alternative to femoral nerve block after total knee arthroplasty (TKA). The aim of the present study was to investigate whether addition of dexamethasone to ropivacaine for ACB is able to prolong analgesia and reduce pain. Study participants were randomized into groups receiving ACB with either 0.5% ropivacaine + normal saline (control group; n=93) or 0.5% ropivacaine + 8 mg dexamethasone (dexamethasone group; n=93). All patients were subjected to identical peri-operative management...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29043003/tiaogeng-yijing-decoction-improves-the-pregnancy-outcomes-of-patients-with-poor-ovarian-response-undergoing-in-vitro-fertilization-embryo-transfer
#2
Hui Xue, Juan Dong, Huijun Xu, Xin Huang, Huangguan Dai, Cuifang Hao
The present study aimed to explore the therapeutic effects of the Tiaogeng Yijing decoction on patients with poor ovarian response (POR) undergoing in vitro fertilization-embryo transfer (IVF-ET), in addition to the underlying molecular mechanisms of these effects. A total of 40 patients were randomly and equally assigned to the treatment or control group. Patients in the treatment group received the Tiaogeng Yijing decoction continuously for three menstrual cycles in addition to microstimulation, while patients in the control group underwent microstimulation only...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29043002/humanin-analogue-s14g-humanin-has-neuroprotective-effects-against-oxygen-glucose-deprivation-reoxygenation-by-reactivating-jak2-stat3-signaling-through-the-pi3k-akt-pathway
#3
Guang-Sheng Gao, Yun Li, Heng Zhai, Jing-Wen Bi, Fu-Sen Zhang, Xiao-Ying Zhang, Shao-Hua Fan
Stroke, characterized by a disruption of blood supply to the brain, is a major cause of morbidity and mortality worldwide. Although humanin, a 24-amino acid polypeptide, has been identified to have multiple neuroprotective functions, the level of humanin in plasma has been demonstrated to decrease with age, which likely limits the effects against stroke injury. A potent humanin analogue, S14G-humanin (HNG), generated by replacement of Ser14 with glycine, has been demonstrated to have 1,000-fold stronger biological activity than humanin...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29043001/effect-of-pingchuan-guben-decoction-on-patients-with-chronic-obstructive-pulmonary-disease-results-from-a-randomized-comparative-effectiveness-research-trial
#4
Cheng-Liang Qian, Rong Fan
Chronic obstructive pulmonary disease (COPD) is known to be a systemic low-grade ongoing inflammation exerting major health and economic burden worldwide. Complementary and alternative medicines, such as Traditional Chinese Medicine, are widely used for the treatment of patients with COPD. The present study was designed to investigate the efficacy of Pingchuan Guben decoction on patients with COPD through a double-blinded, open-labeled, randomized controlled trial. A total of 86 patients were randomly assigned to two groups, with 43 patients in the intervention group and 43 cases in the control group...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29043000/effect-of-entecavir-in-the-treatment-of-patients-with-hepatitis-b-virus-related-compensated-and-decompensated-cirrhosis
#5
Xiao-Dong Gai, Wei-Feng Wu
Chronic hepatitis B virus (CHB) infection is a burden on global healthcare and is associated with a higher risk of serious sequelae, including cirrhosis and hepatocellular carcinoma. The clinical application of entecavir as a treatment for CHB has produced positive outcomes, and so is an attractive form of pharmacological therapy. However, little data exists comparing the safety and efficacy of entecavir for the treatment of hepatitis B virus (HBV)-related compensated, and decompensated cirrhosis, respectively...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042999/pien-tze-huang-inhibits-the-proliferation-of-colorectal-cancer-cells-by-increasing-the-expression-of-mir-34c-5p
#6
Yun Wan, Aling Shen, Fei Qi, Jianfeng Chu, Qiaoyan Cai, Thomas Joseph Sferra, Jun Peng, Youqin Chen
MicroRNAs (miRNAs) are small, short endogenous non-coding RNA that act as oncogenes or tumor suppressors, and serve an important role in various human malignant cancers, including colorectal cancer (CRC). Evidence has indicated that miRNAs regulate the expression of various genes associated with human cancer, in particular the miR-34 family. A well-known traditional Chinese formula, Pien Tze Huang (PZH), has a significant clinical effect on CRC. Previous studies have demonstrated that PZH inhibits CRC growth in vitro and in vivo via multiple mechanisms, including the induction of apoptosis, inhibition of cell proliferation and tumor angiogenesis...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042998/microrna-206-inhibits-the-viability-and-migration-of-medulloblastoma-cells-by-targeting-lim-and-sh3-protein-1
#7
Xuexia Pan, Zhimin Wang, Bin Wan, Zhenwen Zheng
MicroRNA (miR)-206 has been found to be deregulated in various types of human cancer, including medulloblastoma. However, the regulatory mechanism of miR-206 in medulloblastoma growth and metastasis remains largely unclear. In the present study, reverse transcription-quantitative polymerase chain reaction data indicated that miR-206 was significantly downregulated in medulloblastoma tissues compared with adjacent non-tumor tissues (P<0.01). Furthermore, low expression of miR-206 was significantly associated with seeding at presentation and anaplastic histology (P<0...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042997/cd19-cd24-hi-cd38-hi-regulatory-b-cells-are-associated-with-insulin-resistance-in-type-i-hashimoto-s-thyroiditis-in-chinese-females
#8
Min Yang, Changji Du, Yinping Wang, Jun Liu
Hashimoto's thyroiditis (HT) is typically associated with insulin resistance. The aim of the present study was to investigate the role of regulatory B cells (Bregs) in insulin resistance in patients with HT. A total of 52 female patients with type I HT and 35 matched healthy volunteers were enrolled. Demographic and laboratorial data were collected. A 75 g oral glucose tolerance test was performed on each subject. Flow cytometry was performed to evaluate the levels of CD19(+)CD24(hi)CD38(hi) Bregs in peripheral blood...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042996/il-32%C3%AE-promotes-integrin-%C3%AE-v%C3%AE-6-expression-through-the-activation-of-nf-%C3%AE%C2%BAb-in-hscs
#9
Hongcan Liu, Xingfei Pan, Hong Cao, Xin Shu, Haixia Sun, Jianxi Lu, Jiayin Liang, Ka Zhang, Fengqin Zhu, Gang Li, Qi Zhang
Hepatic stellate cell (HSC) activation is important in the pathogenesis of liver fibrosis. However, the molecular mechanism of HSC activation is not completely understood. In the present study, it was demonstrated that interleukin-32γ (IL-32γ) is capable of enhancing intefgrin αvβ6 expression by inducing integrin αvβ6 promoter activity in a dose-dependent manner in HSCs. Furthermore, it was determined that nuclear factor κB (NF-κB) activation is required for IL-32γ-induced integrin αvβ6 expression...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042995/overexpression-of-dominant-negative-ikaros-6-isoform-is-associated-with-resistance-to-tkis-in-patients-with-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia
#10
Changfeng Shao, Jie Yang, Yirong Kong, Cong Cheng, Wei Lu, Hongzai Guan, Haiyan Wang
The clinical significance of the dominant-negative Ikaros 6 (DN-IK6) in the treatment of patients with Philadelphia-positive acute lymphoblastic leukemia (Ph(+)-ALL) with tyrosine kinase inhibitors (TKIs) remains elusive. In the present study, it was demonstrated that DN-IK6 was overexpressed in B-cell (B)-ALL cases compared with T cell-ALL cases at the mRNA and protein levels. Furthermore, nucleotide sequencing revealed that DN-IK6 was due to the deletion of IKAROS family zinc finger 1 exons 4-7. The outcome of patients with Ph(+)-B-ALL with DN-IK6, and treated with TKIs and hyper-cyclophosphamide/vincristine/doxorubicin/dexamethasone regimen were restrospectively evaluated in a 2 year follow-up...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042994/immunological-mechanism-of-low-dose-priming-radiation-resistance-in-walker-256-tumor-model-mice
#11
Li Feng, Ling Qin, Dan Guo, Daping Deng, Feng Lu, Hailiang Li, Narisu Bao, Xiting Yang, Hongyu Ding, Jianguo Li
The aim of the present study was to investigate whether low-dose priming radiation induces antitumor immunity that can be augmented by the modulation of natural killer (NK) cell and cytokine activity using a mouse tumor model. Walker-256 cells were injected into the right flank of male BALB/c mice. At 7 days after inoculation, mice were divided into three groups, including group 1,2,3. In group 1 the mice were without radiation, in group 2 the mice were received 2 Gy radiation only, and in group 3 the mice were radiated with a priming dose of 75 mGy followed by 2 Gy radiation after 24 h...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042993/sitagliptin-ameliorates-high-glucose-induced-cell-proliferation-and-expression-of-the-extracellular-matrix-in-glomerular-mesangial-cells
#12
Guan-Ying Zhang, Dong-Dong Wang, Zheng Cao, Tong Wei, Chen-Xu Liu, Qun-Li Wei
Diabetic nephropathy (DN) is one of the most important causes that leads to end-stage renal disease and the efficacy of strategies currently available for the prevention of DN remains unsatisfactory. Sitagliptin (SIT), which is a dipeptidyl peptidase-4 inhibitor, exhibited a modest beneficial effect on glycated hemoglobin levels and is capable of ameliorating renal ischemia reperfusion injury. By determining the expression of transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), collagen type IV (ColIV) and fibronectin (FN) levels in high glucose-cultured glomerular mesangial cells (MCs), the present study aimed to assess the anti-proliferative and anti-fibrotic effects of SIT on the therapeutic potential for the prevention of DN and its mechanism...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042992/timosaponin-b-iii-exhibits-antidepressive-activity-in-a-mouse-model-of-postpartum-depression-by-the-regulation-of-inflammatory-cytokines-bndf-signaling-and-synaptic-plasticity
#13
Xiao-Li Zhang, Lin Wang, Li Xiong, Feng-Hua Huang, Han Xue
The aim of this study was to investigate the antidepressive effects of timosaponin B-III (TB-III) and the underlying mechanism. A postpartum depression (PPD) mouse model was established by the administration of dexamethasone sodium phosphate during pregnancy. Mice with PPD were assigned to the following groups: Model, fluoxetine and high, medium and low doses of TB-III. Post-parturient mice without PPD served as a normal control group. To examine the effect of TB-III, mice were treated with TB-III, then forced swimming tests (FSTs) and tail suspension tests (TSTs) were performed to evaluate depression...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042991/nuclear-factor-%C3%AE%C2%BAb-signaling-negatively-regulates-high-glucose-induced-vascular-endothelial-cell-damage-downstream-of-the-extracellular-signal-regulated-kinase-c-jun-n-terminal-kinase-pathway
#14
Yunzhi Chen, Fang Guo, Zheng Ru, Hongru Kong, Hongwei Sun, Huajun Yu, Wenjun Yang, Qiyu Zhang, Mengtao Zhou
Diabetes mellitus (DM)-induced high blood sugar severely damages vascular endothelial cells (VECs), which are in direct contact with the blood. Diabetic complications cause difficulties in skin wound healing and VECs are important for this process. Previous studies demonstrated that high blood sugar delayed the repair of wounded VECs, but the underlying mechanism has remained elusive. To explore the effects of diabetic conditions on VEC damage, cells were incubated in a medium with high glucose and then subjected to RNA-sequencing based transcriptome analysis...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042990/changes-of-treg-and-th17-cells-as-well-as-cytokines-in-children-with-acute-bronchitis
#15
Zhiqiang Tu, Haiyan Xue, Wei Chen, Lanfang Cao, Weiqi Zhang
The present study aimed to investigate changes of T-regulatory (Treg) and T-helper (Th)17 cells as well as cytokines in peripheral blood of children with acute bronchitis, and to explore the roles of these cells in the pathogenesis of acute bronchitis. A total of 126 children who had presented at Renji Hospital (Shanghai, China) with acute bronchitis were selected as the observation group and 30 healthy children were selected as the control group. Th17/Tregs in the peripheral blood of the children of the observation group and the control group was detected by flow cytometry...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042989/microrna-22-may-promote-apoptosis-and-inhibit-the-proliferation-of-hypertrophic-scar-fibroblasts-by-regulating-the-mitogen-activated-protein-kinase-kinase-extracellular-signal-regulated-kinase-p21-pathway
#16
Shihua Dong, Yanfeng Sun
Hypertrophic scarring (HS) is a common skin disorder that occurs during the wound healing process, and the pathogenesis of HS remains unclear. Increasing evidence indicated that specific microRNAs (miRs) may be involved in the onset and progression of HS. In the present study, the association between miR-22 and HS was investigated. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was performed to examine the expression of miR-22 in 30 HS and matched normal skin tissues. In addition, human hypertrophic scar fibroblasts (HSFBs) were cultured and transfected with miR-22 mimics, and MTT and Annexin V apoptosis assays were performed to investigate the role of miR-22 in the proliferation and apoptosis of the human HSFBs...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042988/toll-like-receptor-2-and-dectin-1-function-as-promising-biomarker-for-aspergillus-fumigatus-infection
#17
Peng-Peng Zhang, Xiao-Feng Xin, Xiao-Yong Xu, Li-Ping Fang, Jie Wu, Yi Shi
In recent years, along with the wide application of organ transplantation and immunosuppressive agents, as well as the abuse of broad spectrum antibiotics, the incidence of invasive fungal infections has been increasing gradually. The present study aimed to identify novel biomarkers in cells infected with Aspergillus fumigatus. Human umbilical vein endothelial cells (HUVECs) were infected with Aspergillus fumigatus and then harvested at different time-points (0, 1, 2, 4 and 6 h). The expression Toll-like receptor 2 (TLR2) and dectin-1 expression were examined using flow cytometry and western blotting, and fluorescence-based microscopy was used to evaluate their distribution...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042987/upregulation-of-yes-associated-protein-and-transcriptional-co-activator-with-pdz-binding-motif-influences-the-behavior-of-lovo-human-colon-adenocarcinoma-cells
#18
Yu Li, Lan Li, Min Zhu, Limin Ye, Qian Yang
The present study aimed to investigate the role of Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) in the LOVO human colon adenocarcinoma cell line and explore the underlying mechanisms. First, the expression levels of YAP and TAZ were detected in LOVO cells using reverse-transcription quantitative PCR, and the results suggested that YAP and TAZ were faintly expressed in LOVO cells. To investigate the exact role of YAP and TAZ in LOVO cells, stable YAP- and/or TAZ-overexpressing LOVO cell lines were established using YAP and/or TAZ expression plasmids...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042986/sevoflurane-exposure-in-postnatal-rats-induced-long-term-cognitive-impairment-through-upregulating-caspase-3-cleaved-poly-adp-ribose-polymerase-pathway
#19
Yunzhi Ling, Xiaohong Li, Li Yu, Qisheng Liang, Xuewu Lin, Xiaodi Yang, Hongtao Wang, Ye Zhang
The association of anesthetic exposure in infants or young children with the long-term impairment of neurologic functions has been reported previously; however, the underlying mechanisms remain largely unknown. In order to identify dysregulated gene expression underlying long-term cognitive impairment caused by sevoflurane exposure at the postnatal stage, the present study initially performed behavioral tests on adult Wistar rats, which received 3% sevoflurane at postnatal day 7 (P7) for different time course...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042985/long-noncoding-rna-eosinophil-granule-ontogeny-transcript-inhibits-cell-proliferation-and-migration-and-promotes-cell-apoptosis-in-human-glioma
#20
You Wu, Shunli Liang, Bin Xu, Rongbo Zhang, Minzi Zhu, Weiying Zhou, Shuijing Zhang, Jinhui Guo, Linsheng Xu, Hongye Zhu
Glioma is the most common primary brain tumor and represents one of the most aggressive and lethal types of human cancer. Recent advances have implicated long noncoding RNAs (lncRNAs) as crucial mediators of cancer development and progression. The present study aimed to investigate the role of a newly-discovered lncRNA, termed eosinophil granule ontogeny transcript (EGOT), in the aggressive abilities of cells in human glioma. It was initially found that the relative transcription level of EGOT in glioma cancerous tissues was significantly lower than that in adjacent non-cancerous tissues...
October 2017: Experimental and Therapeutic Medicine
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