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Experimental and Therapeutic Medicine

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https://www.readbyqxmd.com/read/29897052/recent-perspectives-of-pediatric-mitochondrial-diseases
#1
Junhua Cao, Hongwei Wu, Zhenguang Li
[This retracts the article DOI: 10.3892/etm.2017.5385.].
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896271/microrna-27a-protects-retinal-pigment-epithelial-cells-under-high-glucose-conditions-by-targeting-tlr4
#2
Xiaolei Tang, Yan Dai, Xiaoli Wang, Jian Zeng, Guirong Li
The present study aimed to investigate whether microRNA-27a (miRNA27a) is associated with the pathogenesis of diabetic retinopathy, and to elucidate the underlying molecular mechanism of any potential association. In retinal pigment epithelial (RPE) cells treated with high glucose, miRNA27a expression, determined by reverse transcription-quantitative polymerase chain reaction analysis, was decreased. Caspase-3/9 activity and B-cell lymphoma 2-associated X (Bax) protein expression was increased in RPE cells subjected to high glucose...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896270/mir-199b-5p-serves-as-a-tumor-suppressor-in-renal-cell-carcinoma
#3
Yulin Lai, Jing Quan, Jia Hu, Peijie Chen, Jinling Xu, Xin Guan, Weijie Xu, Yongqing Lai, Liangchao Ni
MicroRNA (miR)-199b-5p has been reported to have a critical role in various types of malignancy. However, the exact function miR-199b-5p in renal cancer remains to be fully elucidated. The present study aimed to detect the expression levels of miR-199b-5p in renal cell carcinoma (RCC) tissues and RCC cell lines, and investigated the effect of miR-199b-5p in vitro with Cell Counting Kit-8, MTT, scratch wound, Transwell and flow cytometric assays. The results demonstrated that the expression levels of miR-199b-5p were significantly downregulated in RCC tissues and cell lines compared with those in paired adjacent normal renal tissues and a reference cell line, respectively...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896269/beneficial-effects-of-dexmedetomidine-on-early-postoperative-cognitive-dysfunction-in-pediatric-patients-with-tonsillectomy
#4
Chuanlai Han, Rong Fu, Weifu Lei
According to clinical investigations, early postoperative cognitive dysfunction is the most common adverse event in pediatric patients after tonsillectomy. A previous study has indicated that dexmedetomidine (DEX) is an efficient drug for the treatment of postoperative cognitive dysfunction. However, the efficacy of DEX in alleviating early postoperative cognitive dysfunction in pediatric patients following tonsillectomy has remained elusive, which was therefore assessed in the present study. A total of 186 children presenting with cognitive dysfunction subsequent to tonsillectomy were recruited to analyze the efficacy of DEX...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896268/thoracic-manifestation-of-wegener-s-granulomatosis-computed-tomography-findings-and-analysis-of-misdiagnosis
#5
Jiakai Li, Chuangui Li, Jiaojiao Li
The aim of the present study was to investigate the computed tomography (CT) manifestations of Wegener granulomatosis (WG) in the chest and potential reasons for misdiagnosis. Conventional CT scans and clinical data of 45 patients with WG were retrospectively analyzed. Patients typically presented with multiple system involvement, primarily in the upper and lower respiratory tract. The incidence of thoracic involvement was 75.56% (34/45). Radiographic features were varied between cases in the present study, with the most common features being numerous cavitary nodules and masses in the lungs...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896267/lung-injury-caused-by-paraquat-poisoning-results-in-increased-interleukin-6-and-decreased-microrna-146a-levels
#6
Wei Wu, Yong Li
The aim of the present study was to investigate the expression of microRNA (miR)-146a in the pulmonary macrophages, peripheral blood mononuclear cells and serum of patients with lung injury caused by paraquat poisoning, as well as the underlying mechanism of its regulation in the disease. A total of 26 patients with lung injury caused by paraquat poisoning were included in the present study. In addition, 33 healthy subjects were included as the control group. The expression levels of interleukin (IL)-6 mRNA and miR-146a was determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896266/anti-inflammatory-effect-of-polydeoxyribonucleotide-on-zoledronic-acid-pretreated-and-lipopolysaccharide-stimulated-raw-264-7-cells
#7
Jin-Hee Han, Junho Jung, Lakkyong Hwang, Il-Gyu Ko, Ok Hyung Nam, Mi Sun Kim, Jung-Woo Lee, Byung-Joon Choi, Deok-Won Lee
Bisphosphonates are generally used as therapeutic agents for bone diseases. However, previous reports on bisphosphonates-related osteonecrosis of the jaw (BRONJ) demonstrated that inflammation triggers and worsens the disease. Recently, polydeoxynucleotide (PDRN), an A2A receptor agonist, has been suggested for the treatment of various diseases and broadly studied for its anti-inflammatory effect. The present study aimed to measure the effect of PDRN on macrophage cells treated with zoledronic acid (ZA) and lipopolysaccharide (LPS)...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896265/comparison-of-efficacy-complications-and-tgf-%C3%AE-2-expression-between-dhs-and-pfna-in-elderly-patients-with-osteoporotic-femoral-intertrochanteric-fracture
#8
Rao Xu, Jiangying Ru, Feng Ji, Jie Liu, Yong Ji, Zhiquan Wu, Dai Shi
The aim of the present study was to compare the efficacy and complications of two fixation techniques, namely dynamic hip screw (DHS) and proximal femoral nail antirotation (PFNA), in the treatment of osteoporotic femoral intertrochanteric fracture in elderly patients, and to detect changes in transforming growth factor β2 (TGF-β2) expression in the two groups. A total of 100 elderly patients with femoral intertrochanteric fracture were randomly divided into two groups that were treated with either DHS or PFNA...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896264/effects-of-hyperglycaemia-and-elevated-glycosylated-haemoglobin-on-contrast-induced-nephropathy-after-coronary-angiography
#9
Yu-Han Qin, Gao-Liang Yan, Chang-Le Ma, Cheng-Chun Tang, Gen-Shan Ma
In patients undergoing percutaneous coronary intervention after acute myocardial infarction, hyperglycaemia on admission is associated with an increased risk of contrast-induced nephropathy (CIN). However, the effects of hyperglycaemia and elevated glycosylated haemoglobin (HbA1c) on CIN have remained to be fully elucidated. Therefore, a prospective cohort study was performed, comprising 258 patients who underwent coronary angiography between May 2017 and November 2017 at Zhongda Hospital affiliated with Southeast University (Nanjing, China)...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896263/nimesulide-inhibits-proliferation-and-induces-apoptosis-of-pancreatic-cancer-cells-by-enhancing-expression-of-pten
#10
Meifen Chu, Tongtong Wang, Aihua Sun, Yu Chen
Pancreatic cancer is the fourth leading cause of cancer-associated cases of mortality worldwide. Prostaglandin-endoperoxide synthase 2 (COX-2) is considered a therapeutic target for prevention of pancreatic cancer. Nimesulide, a selective COX-2 inhibitor, can induce cell apoptosis, resulting in an anti-cancer effect. However, the mechanism underlying this effect remains to be elucidated. The present study aimed to evaluate the effects of nimesulide on proliferation of PANC-1 cells using an MTT assay. Apoptosis was evaluated by DNA laddering and Annexin V-fluorescein isothiocyanate/propidium iodide-stained flow cytometry...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896262/comparison-of-the-clinical-effects-of-arthroscopic-surgery-vs-open-surgery-for-grade-ii-gluteal-muscle-contracture-in-adults
#11
Ting Zhang, Siyue Xu, Haopeng Li, Xijing He, Feng Zhang
The aim of the present study was to compare the clinical effects of arthroscopic surgery with open surgery for grade II gluteal muscle contracture (GMC) in adults and to discuss the indication and technique for arthroscopic GMC release. The clinical data of 113 adult patients with grade II GMC between 2011 and 2016 was retrospectively collected. Among these patients, 72 patients received open surgery and 41 received arthroscopic surgeryy. The 2 groups were compared in terms of surgical duration, incision size, blood loss, hospital stay, analgesic dose and ranking of postoperative functions and effects...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896261/electro-acupuncture-stimulation-prevents-remifentanil-induced-postoperative-hyperalgesia-by-suppressing-spinal-microglia-in-rats
#12
Yanhu Xie, Jun Ma, Di Wang, Xiaoqing Chai, Chen Gao
The aim of the present study was to assess the effect of electro-acupuncture (EA) stimulation on remifentanil-induced postoperative hyperalgesia (RIPH) and the possible involvement of spinal microglia suppression. A model of RIPH was established using adult male Sprague-Dawley rats by administration of remifentanil at 0.08 mg/kg intravenously for 60 min. The Huantiao and Yanglingquan acupoints were stimulated continuously by EA (2 Hz, ~1 mA) for 90 min from before paw incision to the end of remifentanil administration...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896260/ellagic-acid-promotes-a549-cell-apoptosis-via-regulating-the-phosphoinositide-3-kinase-protein-kinase-b-pathway
#13
Qiong Liu, Xiaobing Liang, Chengwei Niu, Xuelan Wang
The present study aimed to evaluate the anti-cancer effect of ellagic acid in human non-small cell lung cancer (NSCLC) A549 cells and to reveal the potential underlying mechanism. The effects of ellagic acid on the cell proliferation of A549 cells were determined by MTT assay. Cell cycle and apoptosis were measured with flow cytometry and Annexin V-propidium iodide staining. Western blotting was used to measure the expression levels of the phosphatidylinositol 3-kinase (PI3K)/protein kinas B (Akt) signaling pathway and apoptosis-associated proteins...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896259/unilateral-digital-arterial-ligation-combined-with-low-molecular-weight-heparins-in-severed-finger-without-venous-anastomosis
#14
Xueming Chen, Zheng Chen, Jiandong Zhou, Yajun Xu
Curative effect of unilateral digital arterial ligation combined with low molecular weight heparins in the treatment of severed finger without venous anastomosis and its influence on venous crisis was studied. A total of 80 patients with distal severed finger treated in Wuxi No. 9 People's Hospital from May 2014 to July 2016 were selected into the study. According to the random number table, they were divided into the control group (n=40) and the research group (n=40). The patients in control group were treated with unilateral digital arterial ligation, while the patients in research group were treated with unilateral digital arterial ligation combined with low molecular weight heparin...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896258/resveratrol-provides-benefits-in-mice-with-type-ii-diabetes-induced-chronic-renal-failure-through-ampk-signaling-pathway
#15
Haiyan Guo, Linyun Zhang
Type II diabetes-induced ischemic injuries are known to lead to the rapid degeneration of the kidneys as a result of chronic renal failure. Chronic renal failure is a condition, which typically manifests with symptoms including cardiovascular system and left ventricular hypertrophy, atherosclerosis as well as arterial and aortic stiffness. Resveratrol is a multifunctional compound that has been reported to produce beneficial outcomes for patients with type-II diabetes due to prevention of oxidative stress and apoptosis...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896257/differential-network-as-an-indicator-of-osteoporosis-with-network-entropy
#16
Lili Ma, Hongmei Du, Guangdong Chen
Osteoporosis is a common skeletal disorder characterized by a decrease in bone mass and density. The peak bone mass (PBM) is a significant determinant of osteoporosis. To gain insights into the indicating effect of PBM to osteoporosis, this study focused on characterizing the PBM networks and identifying key genes. One biological data set with 12 monocyte low PBM samples and 11 high PBM samples was derived to construct protein-protein interaction networks (PPINs). Based on clique-merging, module-identification algorithm was used to identify modules from PPINs...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896256/early-enteral-nutrition-and-total-parenteral-nutrition-on-the-nutritional-status-and-blood-glucose-in-patients-with-gastric-cancer-complicated-with-diabetes-mellitus-after-radical-gastrectomy
#17
Junli Wang, Jiamin Zhao, Yanling Zhang, Chong Liu
Effects of early enteral nutrition (EEN) or total parenteral nutrition (TPN) support on nutritional status and blood glucose in patients with gastric cancer complicated with diabetes mellitus after radical gastrectomy were investigated. One hundred and twenty-nine patients with gastric cancer complicated with diabetes mellitus type 2 admitted to the First People's Hospital of Jinan (Jinan, China), from June 2012 to June 2016 were selected into the study. According to different nutrition support pathways, these patients were randomly divided into the EEN group and the TPN group...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896255/therapeutic-effects-of-acupuncture-with-mok-a-polyherbal-medicine-on-ptu-induced-hypothyroidism-in-rats
#18
Ji Hye Hwang, Hyo Won Jung, Seok Yong Kang, An Na Kang, Jun Nan Ma, Xiang Long Meng, Min Sub Hwang, Yong-Ki Park
Acupuncture with MOK, a polyherbal medicine (MOK pharmacopuncture), has been used for the treatment of thyroid syndromes including hypothyroidism and hyperthyroidism in traditional Korean medicine. The present study investigated the effect of MOK pharmacopuncture on hypothyroidism and the mechanism underlying its antioxidation and immune regulation effects. Hypothyroidism was induced in Sprague-Dawley rats by subcutaneous injection of Propylthiouracil (PTU; 10 mg/kg) once daily for 4 weeks. MOK was administered by acupuncture on the acupoints around the thyroid gland of PTU-induced hypothyroidism rats once daily for 2 weeks following hypothyroidism induction...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896254/molecular-mechanism-of-the-role-of-carbamyl-erythropoietin-in-treating-diabetic-retinopathy-rats
#19
Xuegu Xu, Yonghao Cai, Yinfei Yu
The aim of the present study was to investigate the therapeutic effects of carbamyl erythropoietin (CEPO) and safflor yellow (SY) in the treatment of rats with diabetic retinopathy (DR) as well as exploring the mechanism of action. Male SD rats were used to establish a diabetes model and streptozotocin-induced retinopathy was also performed in rats. A total of 126 rats with DR were obtained, and model rats were randomly divided into the model (n=42), experimental (n=42) and control (n=42) groups. The rats in the model group were injected with saline, the rats in the experimental group were treated with CEPO, and the rats in the control group were treated with SY...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29896253/effects-of-kangfuxin-solution-on-il-1%C3%AE-il-6-il-17-and-tnf-%C3%AE-in-gingival-crevicular-fluid-in-patients-with-fixed-orthodontic-gingivitis
#20
Yuting Liu, Fengping Mu, Lijuan Liu, Chune Shan
Changes of interleukin (IL)-1β, IL-6, IL-17 and tumor necrosis factor-α (TNF-α) in gingival crevicular fluid in patients with fixed orthodontic gingivitis after treatment with Kangfuxin solution were analyzed to explore the clinical effect of Kangfuxin solution in patients with orthodontic gingivitis. A total of 78 patients diagnosed with fixed orthodontic gingivitis in Weifang People's Hospital from January 2015 to March 2017 were selected. Thirty-nine patients were treated with gingival cleansing as control group, and the other 39 patients were treated with gingival cleansing plus spraying and sublingual administration with Kangfuxin solution as treatment group...
July 2018: Experimental and Therapeutic Medicine
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