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Experimental and Therapeutic Medicine

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https://www.readbyqxmd.com/read/28123514/hpyerglycemic-and-anti-diabetic-nephritis-activities-of-polysaccharides-separated-from-auricularia-auricular-in-diet-streptozotocin-induced-diabetic-rats
#1
Xinyu Hu, Chungang Liu, Xue Wang, Dongxu Jia, Wenqian Lu, Xiaoqi Sun, Yang Liu, Lijia Yuan
Due to substantial morbidity and complications including nephropathy, a search for alternative treatment of diabetes mellitus is urgently required. The present study aimed to investigate the hypoglycemic and anti-diabetic nephropathy activities of polysaccharides separated from Auricularia auricular (AAP). Diet streptozotocin (STZ)-induced diabetic Sprague-Dawley rats were orally treated with metformin (100 mg/kg; positive control) and AAP (100 and 400 mg/kg) for four weeks, and parameters in the serum and liver associated with blood glucose, free radicals and nephropathy were determined...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123513/wilson-s-disease-patient-with-iron-metabolism-discharge-barriers-a-case-report
#2
Guoen Cai, Xinming Huang, Qinyong Ye, Wenting Xiong, Qing Duan
Wilson's disease (WD) is an autosomal genetic disease. In the present study, the patient was a 35-year-old woman who exhibited drinking bucking (bulbar paralysis) and dysphagia for a period of nine years. Genetic analysis of the patient identified the Thr935Met and Pro992Leu mutations, which lead to copper metabolism discharge barriers. Moreover, magnetic resonance imaging revealed a susceptibility-weighted imaging (SWI) hyperintense area in the bilateral substantia nigra and lenticular nuclei. These SWI observations indicated that 'mineral deposits' were present...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123512/sirt4-overexpression-protects-against-diabetic-nephropathy-by-inhibiting-podocyte-apoptosis
#3
Jian-Xia Shi, Qi-Jin Wang, Hui Li, Qin Huang
Diabetic nephropathy is a diabetic complication associated with capillary damage and increased mortality. Sirtuin 4 (SIRT4) plays an important role in mitochondrial function and the pathogenesis of metabolic diseases, including aging kidneys. The aim of the present study was to investigate the association between SIRT4 and diabetic nephropathy in a glucose-induced mouse podocyte model. A CCK-8 assay showed that glucose simulation significantly inhibited podocyte proliferation in a time- and concentration-dependent manner...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123511/effect-of-ulinastatin-a-human-urinary-protease-inhibitor-on-heatstroke-induced-apoptosis-and-inflammatory-responses-in-rats
#4
Zhen Tao, Feng-Qing Hu, Chuan-Fen Li, Tao Zhang, Bing-Zhen Cao, Lian-Qi Cui
Ulinastatin has been demonstrated to protect against heatstroke by reducing cerebral ischemia and damage in rats. In order to extend these observations, apoptosis and systemic inflammatory responses were assessed in rats treated with ulinastatin prior to the initiation of heatstroke. Following the onset of heatstroke, histological analysis revealed that the hippocampal tissues displayed edema and damage. In addition, upregulation of malondialdehyde, inducible nitric oxide synthase (iNOS) and reactive oxygen species and downregulation of superoxide dismutase were observed compared with the respective levels in the control group...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123510/effects-of-prunus-mume-siebold-zucc-in-the-pacemaking-activity-of-interstitial-cells-of-cajal-in-murine-small-intestine
#5
Sang Weon Lee, Sung Jin Kim, Hyungwoo Kim, Dongki Yang, Hyun Jung Kim, Byung Joo Kim
Interstitial cells of Cajal (ICCs) function as pacemaker cells in the gastrointestinal (GI) tract and therefore, serve an important role in regulating GI motility. The effects of a species of plum (Prunus mume Siebold & Zucc.) on cultured ICC cluster-induced pacemaker potentials in the mouse small intestine were investigated, and the effects of a methanolic extract of Prunus mume (m-PM) on ICC pacemaker activities were examined using the whole-cell patch-clamp technique. ICC pacemaker membrane potentials were depolarized by m-PM in a concentration dependent manner in current clamp mode...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123509/different-roles-of-staphylococcus-aureus-enterotoxin-in-different-subtypes-of-nasal-polyps
#6
Ke-Jia Cheng, Shen-Qing Wang, Ying-Ying Xu
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease. The pathogenesis of CRSwNP remains unclear. This study was designed to investigate the role of inflammation and Staphylococcus aureus enterotoxin (SE) in this disease. The study included a total of 74 patients with CRSwNP and 6 controls. A serum Phadiatop assay was conducted to detect atopy status, and serum eosinophil cationic protein (ECP) and total immunoglobulin (Ig)E levels were determined using ELISA. SEA, SEB, total IgE, ECP and myeloperoxidase (MPO) levels in nasal tissue supernatant were measured using ELISA...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123508/aloperine-attenuates-hydrogen-peroxide-induced-injury-via-anti-apoptotic-activity-and-suppression-of-the-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway
#7
Dongliang Ren, Weisong Ma, Baozhen Guo, Shunyi Wang
Aloperine is an alkaloid that exerts significant inhibitive effects on acute inflammation and Type III and IV hypersensitivity caused by a variety of inflammatory agents. The aims of the present study were to investigate whether the protective effect of aloperine attenuates hydrogen peroxide (H2O2)-induced injury, and to identify the underlying mechanisms involved. Nucleus pulposus cells were extracted from adult male Sprague-Dawley rats, and incubated with fresh medium containing 200 µM H2O2 for 24 h. In the study, treatment with aloperine significantly increased cell viability and suppressed apoptosis in H2O2-treated nucleus pulposus cells in a dose-dependent manner...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123507/inhibition-of-the-cyclind1-promoter-in-response-to-sonic-hedgehog-signaling-pathway-transduction-is-mediated-by-gli1
#8
Zhongxiao Lin, Hansong Sheng, Chaoguo You, Ming Cai, Yiping Zhang, Li Sheng Yu, Xiaoming Yu, Jian Lin, Nu Zhang
Medulloblastoma (MB) is the most common malignant tumor of the central nervous system in children. Accumulating evidence suggests a major role for the activation of the sonic hedgehog (SHH) signaling pathway in the development of MB cells; however, the mechanisms underlying the effect of this pathway on tumor survival and growth remain poorly understood. The Gli family zinc finger 1 (Gli1) transcription factor is considered as a mediator of the SHH signaling pathway in MB cells. Therefore, the present study investigated whether the SHH signaling pathway promotes the apoptosis of MB cells via downregulation of Gli1...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123506/ultrasound-and-differential-diagnosis-of-fetal-abdominal-cysts
#9
Chang-Yu Tu
The present study aimed to investigate the use of ultrasound and differential diagnosis to diagnose a fetal abdominal cyst. A retrospective analysis of 41 cases of fetal abdominal cyst, which included ovarian cysts, choledochal cysts, intestinal duplication and mesenteric cysts, was performed. Imaging characteristics of various types of cysts were summarized, compared and discussed. Among 41 fetal abdominal cyst cases, there were 21 cases of ovarian cysts, 11 cases of bile duct cyst, six cases of intestinal duplication and three cases of mesenteric cyst...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123505/the-effect-of-resveratrol-on-hypertension-a-clinical-trial
#10
Marios Theodotou, Konstantinos Fokianos, Alexia Mouzouridou, Cornelia Konstantinou, Andrea Aristotelous, Dafni Prodromou, Asimina Chrysikou
The aim of this clinical trial was to investigate the effects of Evelor, a micronized formulation of resveratrol (RESV; 3,5,4'-trihydroxy-trans-stilbene), in patients with primary hypertension. RESV is a stilbenoid and phytoalexin produced by several plants in response to injury or attack by pathogens, such as bacteria and fungi. Patients included in the clinical trial were split into the following two groups, based on the severity of their disease: Group A (n=46), stage I hypertension [systolic blood pressure (SBP), 140-159 mmHg; diastolic blood pressure (DBP), 90-99 mmHg] and Group B (n=51), stage II hypertension (SBP, 160-179 mmHg; DBP, 100-109 mmHg)...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123504/identification-and-functional-characterization-of-a-novel-thyrotropin-receptor-mutation-v87l-in-a-chinese-woman-with-subclinical-hypothyroidism
#11
Hong-Mei Zhang, Ya-Qin Zhou, Yan Dong, Qing Su
The thyrotropin receptor (TSHR) gene has been defined as a highly mutable gene. Mutations in the TSHR gene result in either gain or loss of the receptor function. Subclinical hypothyroidism (SH) is a clinical condition defined as an elevated serum TSH level associated with normal free thyroxine and free triiodothyronine. Chronic autoimmune thyroiditis is the most frequent cause of subclinical hypothyroidism in adults. In rare cases, a loss-of-function mutation of TSHR is the cause of SH. In the present study, a novel TSHR mutation (V87L; confirmed to be a loss-of-function mutation) was identified in a 59-year-old Chinese woman, as the potential cause of the patient's subclinical hypothyroidism...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123503/d-dimer-level-for-predicting-the-in-hospital-mortality-in-liver-cirrhosis-a-retrospective-study
#12
Yun Li, Xingshun Qi, Hongyu Li, Junna Dai, Han Deng, Jing Li, Ying Peng, Xu Liu, Xiaolin Sun, Xiaozhong Guo
The present study aimed to examine the correlation of D-dimer levels with the Child-Pugh and MELD scores, as well as to determine the predictive ability of D-dimer level for the in-hospital mortality of liver cirrhosis patients. All cirrhotic patients who were consecutively admitted to our hospital between January 2011 and June 2014, and underwent D-dimer tests on admission were retrospectively analyzed. Pearson's χ(2) tests were employed to evaluate the correlations of D-dimer levels with Child-Pugh and MELD scores...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123502/translationally-controlled-tumor-protein-activates-the-transcription-of-oct-4-in-kidney-derived-stem-cells
#13
Ying Jing, Liang-Liang He, Chang-Lin Mei
The molecular mechanisms underlying translationally-controlled tumor protein (TCTP) in the activation of octamer-binding transcription factor 4 (Oct-4) in kidney-derived stem cells have not been characterized. The aim of the present study was to identify the transcriptional activation of Oct-4 by TCTP in kidney-derived stem cells. Homology-directed repair cDNA inserted into Fisher 344 transgenic (Tg) rats and the mouse strain 129/Svj were used for the experiments. Diphtheria toxin (DT; 10 ng/kg) injected into the Tg rats created the kidney injury, which was rapidly restored by the activation of kidney-derived stem cells...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123501/identification-of-the-molecular-mechanisms-underlying-dilated-cardiomyopathy-via-bioinformatic-analysis-of-gene-expression-profiles
#14
Hu Zhang, Zhuo Yu, Jianchao He, Baotong Hua, Guiming Zhang
In the present study, gene expression profiles of patients with dilated cardiomyopathy (DCM) were re-analyzed with bioinformatics tools to investigate the molecular mechanisms underlying DCM. Gene expression dataset GSE3585 was downloaded from Gene Expression Omnibus, which included seven heart biopsy samples obtained from patients with DCM and five healthy controls. Differential analysis was performed using a Limma package in R to screen for differentially expressed genes (DEGs). Functional enrichment analysis was subsequently conducted for DEGs using the Database for Annotation, Visualization and Integration Discovery...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123500/effects-of-low-dose-tolvaptan-on-electrolyte-abnormality-and-hemodynamic-parameters-in-a-liver-cirrhosis-associated-portopulmonary-hypertension-patient-a-case-report
#15
Yoshito Ogihara, Norikazu Yamada, Kaoru Dohi, Akimasa Matsuda, Satoshi Ota, Ken Ishikura, Mashio Nakamura, Masaaki Ito
The present study reported a case of portopulmonary hypertension (POPH) that was secondary to underlying liver cirrhosis in a 58-year-old woman, who was successfully treated with low-dose tolvaptan. The patient had suffered from refractory peripheral edema and electrolyte abnormalities, including severe hypokalemia, under the combination therapy of sildenafil, ambrisentan, furosemide and spironolactone. Subsequent to the initiation of low-dose tolvaptan at 3.75 mg/day with concurrent de-escalation of the dose of furosemide, the daily urine volume increased, peripheral edema improved and the serum potassium level increased immediately...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123499/anti-inflammatory-and-neuroprotective-effects-of-sanguinarine-following-cerebral-ischemia-in-rats
#16
Qin Wang, Peng Dai, Han Bao, Ping Liang, Wei Wang, An Xing, Jianbin Sun
Stroke is one of the leading causes of mortality worldwide. Protective agents that can diminish injuries caused by cerebral ischemia-reperfusion (I/R) are important in alleviating the harmful outcomes of stroke. The aim of the present study was to investigate the protective role of sanguinarine in cerebral I/R injury. A rat middle cerebral artery occlusion model was used to assess the clinical effect of sanguinarine, and inflammatory cytokines in the serum were detected by ELISA. Western blotting was performed to examine the change in levels of apoptosis-associated proteins in the injured brains...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123498/allicin-inhibits-tubular-epithelial-myofibroblast-transdifferentiation-under-high-glucose-conditions-in-vitro
#17
Hong Huang, Fenping Zheng, Xuehong Dong, Fang Wu, Tianfeng Wu, Hong Li
Previous studies have suggested that tubular epithelial-mesenchymal transition (EMT) is an important event in renal tubulointerstitial fibrosis, which is a clinical characteristic of diabetic nephropathy. The present study aimed to investigate the effect of allicin, the major biological active component of garlic, on the EMT of a human renal proximal tubular epithelial cell line (HK-2) cultured under high glucose concentrations. HK-2 cells were exposed for 48 h to 5.5 or 25 mmol/l D-glucose, 25 mmol/l D-glucose plus allicin (2...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123497/odontogenic-epithelial-proliferation-is-correlated-with-cox-2-expression-in-dentigerous-cyst-and-ameloblastoma
#18
Mohammed Amjed Alsaegh, Hitoshi Miyashita, Takahiro Taniguchi, Sheng Rong Zhu
Investigation of cyclooxygenase (COX)-2 in dentigerous cyst and ameloblastoma may help to improve understanding of the nature and behavior of odontogenic cysts and tumors, and in addition may eventually represent a definitive target for a pharmacological approach in the management of these lesions. The aim of this study was to evaluate COX-2 expression and its correlation with the proliferation of odontogenic epithelium in these lesions. Dentigerous cysts (n=16) and ameloblastomas (n=17) were evaluated. Detection of Ki-67 and COX-2 protein expression was conducted by immunohistochemistry...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123496/biodegradable-poly-l-lactide-co-glycolide-copolymer-pin-fixation-of-a-traumatic-patellar-osteochondral-fragment-in-an-11-year-old-child-a-novel-surgical-approach
#19
Juha-Jaakko Sinikumpu, Willy Serlo
Treating displaced patellar bone fractures in growing children remains a challenge for orthopedic surgeons. Removal of loose bone fragments may prolong healing time and result in early onset osteoarthrosis. Therefore, primary fixation of osteochondral fragments is preferred. Metallic pin and screw implants are typically used for fixation, as there is little evidence available regarding the use of modern biodegradable implants in traumatic patellar fractures of a premature skeleton. The present report describes a novel operative technique using headless poly-L-lactide-co-glycolide (PLGA) pins in treating an 11-year-old girl with a patellar fracture from a cycling injury...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28123495/effects-of-the-mapk-pathway-and-the-expression-of-car-in-a-murine-model-of-viral-myocarditis
#20
Ling Niu, Chunli Li, Zhenzhou Wang, Hui Xu, Xinjiang An
The pathogenesis of viral myocarditis (VMC) is not fully understood. This study aimed to examine the relationship between coxsackie-adenovirus receptor (CAR) and the p38 mitogen activated protein kinase (MAPK) pathway mechanisms in a mouse model. Three groups of mice were established: 5 mice in a control group injected with saline, 15 in the model group injected with coxsackie virus B3 (CVB) and 15 in the intervention group injected with CVB3 but treated with the p38 MAPK inhibitor SB203580. Mice were sacrificed at days 1, 5, 10, 15 and 30 and cardiac tissues were isolated to perform the tests...
January 2017: Experimental and Therapeutic Medicine
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