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Experimental and Therapeutic Medicine

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https://www.readbyqxmd.com/read/27899958/effects-of-adipose-stem-cell-conditioned-medium-on-the-migration-of-vascular-endothelial-cells-fibroblasts-and-keratinocytes
#1
Li Hu, Jiajia Zhao, Jiarong Liu, Niya Gong, Lili Chen
[This retracts the article DOI: 10.3892/etm.2013.887.].
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882184/phosphorylation-of-osteopontin-has-proapoptotic-and-proinflammatory-effects-on-human-knee-osteoarthritis-chondrocytes
#2
Shu-Guang Gao, Yang Yu, Chao Zeng, Shi-Tao Lu, Jian Tian, Chao Cheng, Liang-Jun Li, Guang-Hua Lei
The aim of the present study was to investigate the effects of phosphorylated osteopontin (p-OPN) on apoptosis and pro-inflammatory cytokine expression in human knee osteoarthritis (OA) chondrocytes. Human knee OA chondrocytes obtained from patients who underwent total knee arthroplasty were treated with p-OPN, OPN or buffer. Reverse transcription quantitative-polymerase chain reaction (RT-qPCR) and western blot analysis were used to assess the expression levels of proinflammatory factors, including interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6 and nuclear factor (NF)-κB...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882183/psychiatric-symptoms-and-limb-tremors-associated-with-central-pontine-myelinolysis-a-case-of-alcoholism-without-hyponatremia
#3
Xue-Min Feng, Teng Zhao, Chun-Kui Zhou, Jing-Yao Liu
Central pontine myelinolysis (CPM), also known as osmotic demyelination syndrome, is a rare demyelinating disorder characterized by the loss of myelin in the center of the basis pontis. In this case report, an alcoholic patient with CPM and acquired demyelinating lesion of the basis pontis is described. The patient is a 70 year-old woman who presented with intermittent psychiatric symptoms and limb tremors following two months of alcohol abuse. During admission, magnetic resonance imaging (MRI) revealed hyperintensity on T2 weighted images and fluid-attenuated inversion-recovery imaging in the central pons without contrast enhancement...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882182/disease-progression-in-chinese-patients-with-hepatitis-c-virus-rna-positive-infection-via-blood-transfusion
#4
Yan-Feng Pan, Yan Zheng, Tao Qin, Lei Feng, Qian Zhang, Xiao-Gong Ping, Yan-Ting Pan, Xiao-Ping Wang, Li Bai, Hua-Hua Li
The majority of patients with hepatitis C virus (HCV) in China were infected via blood transfusion prior to the year 1996. In this systematic retrospective cohort study, disease progression in 804 consecutive patients with transfusion-acquired HCV is investigated. In addition, the occurrence of compensated cirrhosis, decompensated cirrhosis and hepatocellular carcinoma (HCC) is analyzed among these patients, along with the risk factors for disease progression. Patients with cirrhosis or HCC were classified as the serious development group (SD group) and the remaining patients with chronic hepatitis were classified as the hepatitis group (H group)...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882181/angiogenin-is-upregulated-during-the-alloreactive-immune-response-and-has-no-effect-on-the-t-cell-expansion-phase-whereas-it-affects-the-contraction-phase-by-inhibiting-cd4-t-cell-apoptosis
#5
Theodoros Eleftheriadis, Georgios Pissas, Maria Sounidaki, Nikolaos Antoniadis, Georgia Antoniadi, Vassilios Liakopoulos, Ioannis Stefanidis
Under growth conditions, angiogenin is translocated into the nucleus, where it enhances ribosomal RNA transcription, facilitating increased protein synthesis and cellular proliferation. During stress conditions, angiogenin is sequestered in the cytoplasm, where it cleaves transfer RNA (tRNA) to produce tRNA-derived, stress-induced small RNAs (tiRNAs) that inhibit global protein synthesis, but increase the translation of anti-apoptotic factors. In the present study, the role of angiogenin in the human alloreactive immune response was evaluated using mixed lymphocyte reactions (MLRs) and neamine, an inhibitor of angiogenin nuclear translocation...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882180/concentrations-of-fetuin-a-osteoprotegerin-and-%C3%AE-klotho-in-patients-with-alcoholic-liver-cirrhosis
#6
Andrzej Prystupa, Anna Dąbrowska, Jarosław Jerzy Sak, Jerzy Tarach, Anna Toruń-Jurkowska, Patrycja Lachowska-Kotowska, Grzegorz Dzida
The aim of the present study was to evaluate the concentrations of fetuin-A, osteoprotegerin (OPG) and α-Klotho protein in patients with alcoholic cirrhosis at different stages of the disease, and to demonstrate that fetuin-A, osteoprotegin and α-Klotho may be used as markers of the severity of cirrhosis. A total of 54 patients with alcoholic liver cirrhosis treated in various hospitals in the Lublin region of Poland were randomly enrolled. The control group consisted of 18 healthy individuals without liver disease, who did not drink alcohol...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882179/acroosteolysis-in-systemic-sclerosis-an-insight-into-hypoxia-related-pathogenesis
#7
Simon Siao-Pin, Laura-Otilia Damian, Laura Mirela Muntean, Simona Rednic
Acro-osteolysis, or bony resorption of the terminal digital tufts, is a well-recognized, but under-researched, feature of systemic sclerosis. The mechanisms that disturbs local homeostatic balance of bone formation and resorption in favor of osteoclast activation and pathological bone loss remain to be established. Vascular alterations and reduced capillary density impair tissue oxygenation in systemic sclerosis, and the resulting hypoxia might contribute directly to the disease progression. In this paper we summarize the current evidence for hypoxia as the common pathophysiological denominator of digital vasculopathy and enhanced osteoclastic activity in systemic sclerosis-associated acroosteolysis...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882178/modulatory-effects-of-feeding-pregnant-and-lactating-mice-rhodiola-kirilowii-extracts-on-the-immune-system-of-offspring
#8
Sławomir Lewicki, Barbara Joanna Bałan, Ewa Skopińska-Różewska, Robert Zdanowski, Marta Stelmasiak, Łukasz Szymański, Wanda Stankiewicz
Plants of Rhodiola genus are medicinal herbs that have a number of therapeutic properties, including anti-inflammatory and immunomodulatory activity. The present study aimed to determine whether the use Rhodiola kirilowii as an immunostimulant during pregnancy has an adverse effect on the development of the offspring immune system. Following mating, pregnant mice were placed in three groups that were fed during pregnancy and lactation with R. kirilowii aqueous extract (RKW; 20 mg/kg), R. kirilowii 50% hydro-alcoholic extract (RKW-A; 20 mg/kg) or water (control group), receiving water...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882177/catechol-o-methyltransferase-promoter-hypomethylation-is-associated-with-the-risk-of-coronary-heart-disease
#9
Jinyan Zhong, Xiaoying Chen, Nan Wu, Caijie Shen, Hanbin Cui, Weiping Du, Zhaoxia Zhang, Mingjun Feng, Junsong Liu, Shaoyi Lin, Lulu Zhang, Jian Wang, Xiaomin Chen, Shiwei Duan
Catechol-O-methyltransferase (COMT) gene variation is known to be associated with the risk of acute coronary events. The purpose of the present study was to investigate the contribution of COMT promoter methylation towards the risk of coronary heart disease (CHD). COMT methylation was evaluated in 48 CHD cases and 48 well-matched non-CHD controls using bisulfite pyrosequencing technology. The results demonstrated that CHD cases had a significantly lower level of methylation at COMT CpG3 sites compared with the controls (33...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882176/effect-of-the-interaction-between-atorvastatin-and-selective-serotonin-reuptake-inhibitors-on-the-blood-redox-equilibrium
#10
Mariola Herbet, Monika Gawrońska-Grzywacz, Magdalena Izdebska, Iwona Piątkowska-Chmiel
Cardiovascular disease and depression often occur simultaneously in the same patient. Long-term polypharmacotherapy can lead to drug-induced oxidative stress. Data concerning the effects of concomitant treatment with atorvastatin and selective serotonin reuptake inhibitors (SSRIs) are lacking. The aim of the present study was to examine oxidative stress parameters in the blood of rats after 28 days treatment with atorvastatin combined with fluoxetine or paroxetine. The study was carried out on male Wistar rats weighing 200-250 g...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882175/tea-polyphenols-protect-against-ischemia-reperfusion-induced-liver-injury-in-mice-through-anti-oxidative-and-anti-apoptotic-properties
#11
Jin Tao, Xinhong Shen, Yonghong Ai, Xiaojing Han
Tea polyphenols (TPs), which are derived from tea extracts, are a class of chemicals containing polyphenol hydroxyls that have been observed to have strong anti-oxidative properties. Previous studies have demonstrated that TP can protect against hepatic ischemia/reperfusion (I/R) injury; however, the underlying mechanism remains unknown. In the present study, the mechanism underlying TPs protective effects against I/R-induced liver damage was investigated, focusing on its anti-oxidative and anti-apoptotic bioactivities...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882174/reduction-of-p38-mitogen-activated-protein-kinase-and-cyclooxygenase-2-signaling-by-isoflurane-inhibits-proliferation-and-apoptosis-evasion-in-human-papillomavirus-infected-laryngeal-papillomas
#12
Hongbo Ren, Xiaojuan Shi, Ying Li
Human laryngeal papilloma (LP) is a human papillomavirus-induced hyperplastic tumor of the respiratory tract, which is characterized by rapid growth and apoptosis resistance. Isoflurane (ISO) inhibits proliferation and elicits apoptosis in cancer cells. The results of the present study found that the mRNA and protein levels of cyclooxygenase-2 (COX2) were higher in LP tissues than in normal laryngeal samples, and prostaglandin E2 (PGE2) production was increased in LP cells, as determined by quantitative polymerase chain reaction, western blot and radioimmunoassay analyses...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882173/anti-human-fibroblast-growth-factor-21-monoclonal-antibody-preparation-characterization-and-analysis-of-in-vitro-bioactivity
#13
Liangjun Ding, Zhichao Hao, Qingyan Yuan, Pengfei Xu, Yinhang Yu, Deshan Li
Human fibroblast growth factor 21 (hFGF-21) is involved in numerous metabolic processes and elevated hFGF-21 levels are associated with many metabolic diseases. However, the role hFGF-21 serves in the metabolic system is not fully understood. A humanized anti-hFGF-21 monoclonal antibody (mAb) would provide a novel method for further investigations into the role hFGF-21 serves in the metabolic system and related diseases, which may reveal therapeutic targets for future treatment of these diseases. The present study aimed to prepare an anti-hFGF-21 mAb, followed by identification of its characteristics and bioactivity in vitro...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882172/downregulated-mir-486-5p-acts-as-a-tumor-suppressor-in-esophageal-squamous-cell-carcinoma
#14
Yunfeng Yi, Xiujuan Lu, Jianming Chen, Changjie Jiao, Jing Zhong, Zhiming Song, Xiaoping Yu, Baoli Lin
microRNAs (miRNAs/miRs) are crucial regulators of gene expression at the post-translational level through promoting mRNA degradation or the repression of translation of target genes. miRs have been confirmed to serve a dominant role in tumor biology. miR-486-5p has been ascertained to be involved in non-small-cell lung cancer, breast cancer and hepatocellular carcinoma; however, the expression and function of miR-486-5p in esophageal squamous cell carcinoma (ESCC) has yet to be elucidated. The present study aimed to analyze the expression levels of miR-486-5p in ESCC tissues and paired normal adjacent tissues, and determine the effects of miR-486-5p on esophageal cancer cells using MTT, wound scratch and apoptosis assays...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882171/role-of-microrna-141-in-colorectal-cancer-with-lymph-node-metastasis
#15
Li Feng, Hongqing Ma, Liang Chang, Xinliang Zhou, Na Wang, Lianmei Zhao, Jing Zuo, Yudong Wang, Jing Han, Guiying Wang
The present study aimed to investigate the role of microRNA (miR)-141 in the pathogenesis of colorectal cancer (CRC). In total, 58 CRC patients were included in the present study. The mRNA and protein expression levels of mitogen-activated protein kinase 4 (MAP4K4) were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis, respectively. The miRNA-141 expression was measured by RT-qPCR, while serum MAP4K4 content was detected by enzyme-linked immunosorbent assay...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882170/acute-encephalitis-with-refractory-repetitive-partial-seizures-a-case-report-and-literature-review
#16
Bin Zhang, Lin Wang
A male 46 year-old patient was admitted to the Emergency Intensive Care Unit of Qinghai Provincial People's Hospital (Xining, China) in December 2008 with complaints of a headache and fever that had lasted for three days. In addition, the patient had experienced two general convulsions accompanied with consciousness disorders for 7 h. Although the patient's clinical manifestations, laboratory tests and cerebrospinal fluid examinations were consistent with numerous features associated with acute encephalitis, the patient's clinical course was different to that of acute encephalitis, and the prognosis was poor...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882169/efficacy-of-mesenchymal-stem-cells-in-treating-patients-with-osteoarthritis-of-the-knee-a-meta-analysis
#17
Gang-Hua Cui, Yang Yang Wang, Chang-Jun Li, Chen-Hui Shi, Wei-Shan Wang
To assess the clinical efficacy and safety of mesenchymal stem cell (MSC) treatment for osteoarthritis of the knee (KOA), a systematic electronic literature search was performed on PubMed, EMBASE and Web of Science. Studies published in English from the earliest record to December 2014 were searched using the following keywords: Cartilage defect, cartilage repair, osteoarthritis, KOA, stem cells, MSCs, bone marrow concentrate (BMC), adipose-derived mesenchymal stem cells, synovial-derived mesenchymal stem cells and peripheral blood-derived mesenchymal stem cells...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882168/monozygotic-twins-with-infantile-neuroaxonal-dystrophy-a-case-report-and-literature-review
#18
Haifeng Li, Yan Zou, Xinhua Bao, Hui Wang, Jiangping Wang, Huiying Jin, Yuping Che, Xiaoyan Tang
Infantile neuroaxonal dystrophy (INAD) is a rare neurodegenerative disease with early onset. PLA2G6 gene mutations have been identified in the majority individuals with INAD. In future, molecular diagnosis of INAD will replace the invasive biopsies used previously. In the present report, monozygotic male twins with INAD were referred The Children's Hospital (Zhejiang University School of Medicine, Zhejiang, China) at fifteen months old for delayed development. The older brother was found to have developmental stagnation when he was 6 months old...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882167/expression-and-functions-of-the-stat3-sclip-pathway-in-chronic-myeloid-leukemia-cells
#19
Li Li, De Zhou, Yanlong Zheng, Wanzhuo Xie
Chronic myeloid leukemia (CML) is a blood cell cancer with increased proliferation of granulocytes. Signal transducers and activators of transcription 3 (STAT3) is an important regulator of CML. To investigate the possible downstream factors of STAT3 and gain more insight into CML-related pathways, this study focused on the superior cervical ganglia protein 10-like protein (SCLIP, or SCG 10-like protein) and analyzed the functions of the STAT3-SCLIP pathway. The effects of STAT3 phosphorylation on SCLIP expression were examined by western blotting...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882166/galanin-receptor-2-mediates-antifibrogenic-effects-of-galanin-on-hepatic-stellate-cells
#20
Lingnan He, Zhenghong Li, Da Zhou, Yongnian Ding, Leiming Xu, Yuanwen Chen, Jiangao Fan
Galanin is an endogenous factor involved in the negative regulation of the biological effects of leptin in bioenergetic metabolism. Leptin promotes fibrogenic effects in hepatic stellate cells (HSCs), however, little is known about the effects of galanin on HSCs. In the present study, the biological functions of galanin and its receptors (GalRs) in HSCs were investigated using cell culture in vitro. It was found that galanin and GalR3 mRNA are expressed in quiescent and activated HSCs. GalR2 expression was undetectable in quiescent HSCs but was markedly induced in activated HSCs...
November 2016: Experimental and Therapeutic Medicine
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