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Experimental and Therapeutic Medicine

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https://www.readbyqxmd.com/read/30250527/effect-of-transient-ulnar-artery-compression-on-radial-artery-diameter
#1
Mustafa Adem Yilmaztepe, Erdem Yilmaz
The transradial approach is widely preferred in coronary procedures. A small radial artery diameter (RAD) is the most important factor affecting successful access. Various maneuvers and medications have been used to increase the RAD and thereby facilitate RA cannulation. Ulnar artery compression (UAC) for 30 min has been indicated to be effective in increasing the RAD and facilitating RA access. The aim of the present preliminary study was to assess the effect of transient UAC for 1 min on the RAD. A total of 151 patients were included in the present study...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250526/intrapancreatic-accessory-spleen-evaluation-with-ct-and-mri
#2
Qianjiang Ding, Zhihao Ren, Jianhua Wang, Xiaolong Ma, Jian Zhang, Gaofeng Sun, Changjing Zuo, Hao Gu, Hui Jiang
The aim of the present study was to evaluate the characteristics of computed tomography (CT) and magnetic resonance imaging (MRI), particularly diffusion-weighted imaging (DWI), in the imaging of intrapancreatic accessory spleen (IPAS). The clinical and pathological records of 9 patients, including 8 patients with IPAS and 1 patient with splenosis, were reviewed. The patients had undergone plain and triple-phase enhanced CT scanning (n=9) and MRI scanning (n=8). The lesions of the 8 IPAS patients were located in the pancreatic tail, and were round (n=3), oval (n=4) or triangular (n=1) in shape...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250525/clinical-treatment-of-traumatic-optic-neuropathy-in-children-summary-of-29-cases
#3
Min Chen, Yan Jiang, Jisheng Zhang, Na Li
Clinical features and treatments for traumatic optic neuropathy (TON) in children are reported. Twenty-nine children were enrolled in the Affiliated Hospital of Qingdao University from April 1999 to May 2015 for retrospective analysis. Of these 29 patients, 5 received drug therapy, and 24 received drug therapy combined with surgical therapy. Among the patients who received surgical therapy, 23 received nasal endoscopic optic decompression under general anaesthesia, and 1 received nasal endoscopic orbital decompression under general anaesthesia...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250524/comprehensive-analysis-of-gene-expression-profiles-associated-with-proliferative-diabetic-retinopathy
#4
Meng-Ting Gong, Wen-Xing Li, Qing Zhang, Wen-Wen Lv, Zheng-Hong He, Shu-Li Zhou, Hui Zhang, Jing Wang, Kan He
Proliferative diabetic retinopathy (PDR) is characterized by neovascularization on the surface of the retina or the optic disc, which is associated with environmental and genetic factors. However, its regulatory mechanism remains to be fully elucidated, particularly at a multiomics level. In the present study, a comprehensive analysis was performed of the gene expression profile of fibrovascular membranes (FVMs) associated with PDR, including an analysis of differentially expressed genes, functional enrichment, and regulation of transcription factors (TFs)...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250523/establishment-and-evaluation-of-a-beagle-model-of-grade-iii-pancreatic-trauma
#5
Hanjing Gao, Qing Song, Faqin Lv, Bin Shi, Pengfei Wang, Yiru Wang, Yan Zhang, Li Yang, Yukun Luo, Xingguo Mei, Jie Tang
Pancreatic trauma (PT) is a severe abdominal injury that is often combined with multiple organ injury. It is a severe disease that is difficult to diagnose and has a high mortality rate, particularly for grade III PT. The pathogenesis, disease progress and complications have not been fully investigated due to the lack of a reliable animal model. To address this, a Beagle model of grade III PT was established in the present study using a procedure involving rupture of the main pancreatic duct. Peripancreatic effusions and the degree of pancreatic damage were examined by routine ultrasound and contrast-enhanced ultrasound (CEUS)...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250522/local-injection-of-dexamethasone-helping-to-prevent-lower-back-pain-after-epidural-delivery-analgesia
#6
Zhaoxia Yang, Lanlan Liu, Jinmei Mu, Wenchen Guo, Shunrong Li, Yanyan Jing, Yanyan Liu
This report aims to retrospectively analyze the clinical effect of local pretreatment with dexamethasone (DXMS) on lower back pain after epidural labor analgesia. Patients with epidural labor analgesia treated in People's Hospital of Rizhao from January 2014 to December 2016 were studied. All 368 cases involved were pregnant primipara with full-term single birth. Parturient received injection of DXMS and lidocaine mixture around the epidural puncture point was the observation group (n=188), and parturient received injection of 0...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250521/sericin-enhances-the-insulin-pi3k-akt-signaling-pathway-in-the-liver-of-a-type-2-diabetes-rat-model
#7
Chengjun Song, Donghui Liu, Songhe Yang, Luyang Cheng, Enhong Xing, Zhihong Chen
The aim of the current study was to investigate the regulatory effect of sericin on the hepatic insulin-phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway in a type 2 diabetes rat model. Male Sprague Dawley rats were randomly divided into four groups: Control group, diabetic model group, high-dose sericin group and low-dose sericin group, with 12 rats in each group. Fasting blood glucose was detected by the glucose oxidase method, and hepatic glycogen was determined by periodic acid-Schiff staining...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250520/oxidative-status-of-cardinal-ligament-in-pelvic-organ-prolapse
#8
Gui Fang, Li Hong, Cheng Liu, Qing Yang, Qifan Zhang, Yang Li, Bingshu Li, Debin Wu, Wenying Wu, Hua Shi
Pelvic organ prolapse (POP) is a common and distressing health problem in adult women, but the pathophysiological mechanism is yet to be fully elucidated. Previous studies have indicated that oxidative stress may be associated with POP. Thus, the aim of the present study was to investigate the oxidative status of pelvic supportive tissue in POP and further demonstrate that oxidative stress is associated with the pathogenesis of POP. A total of 60 samples were collected from females undergoing hysterectomy for POP or cervical intraepithelial neoplasia (CIN)...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250519/echinocandins-for-pneumocystis-jirovecii-pneumonia-in-non-hiv-patients-a-case-report
#9
Hui-Bin Huang, Jing-Min Peng, Bin Du
For the past two decades, echinocandins have shown prophylactic and therapeutic efficacy in patients with Pneumocystis jirovecii pneumonia (PJP), due to their ability to inhibit the synthesis of β-1, 3-glucan, a major component of the cell wall of P. jirovecii . The present study reported two cases of human immunodeficiency virus (HIV)-negative patients who received echinocandins as a salvage therapy at Peking Union Medical College Hospital (Beijing, China), both of whom exhibited good responses to treatment...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250518/establishment-and-characterization-of-mca-rh7777-cells-using-virus-mediated-stable-overexpression-of-enhanced-green-fluorescent-protein
#10
Wei Zhang, Sheng Qian, Guowei Yang, Liang Zhu, Bo Zhou, Xudong Qu, Zhiping Yan, Rong Liu, Jianhua Wang
Hepatocellular carcinoma (HCC), the most common primary tumor of the liver, has a poor prognosis, rapid progression. The aim of the current study was to establish a stable lentiviral expression vector for enhanced green fluorescent protein (EGFP) and to evaluate biological characteristics on HCC growth and migration following transfection of HCC cells with EGFP. McA-RH7777 cells were transfected with EGFP overexpression lentiviral vector. Cell activity and mobility were monitored with a Cell-IQ Analyzer. Transwell assays were performed to detect invasiveness and flow cytometry was performed for cell cycle analysis...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250517/microrna-663b-promotes-cell-proliferation-and-epithelial-mesenchymal-transition-by-directly-targeting-smad7-in-nasopharyngeal-carcinoma
#11
Meirong Wang, Min Jia, Kun Yuan
MicroRNAs (miRs) serve important roles in the development of various types of human cancer, including nasopharyngeal carcinoma (NPC). In the present study, the expression levels of miR-663b in NPC were investigated and its role and underlying mechanisms were examined. Reverse transcription-quantitative polymerase chain reaction was performed to assess miR-663b expression levels in NPC tissues and C666-1 cells. TargetScan was applied to predict the putative targets of miR-663b and the dual luciferase reporter assay was used to confirm the predictions...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250516/potential-use-of-compounds-from-sea-cucumbers-as-mdm2-and-cxcr4-inhibitors-to-control-cancer-cell-growth
#12
Teresa Liliana Wargasetia, Sofy Permana, Nashi Widodo
Ineffectiveness of cancer therapy may originate in the incompatibility of the treatment with various mutations in the cancer cells. Finding novel anticancer treatments that work efficiently for varying types of cancer cells remains challenging. Previous studies have identified that compounds in sea cucumbers are capable of inhibiting the growth of cancer cells and inducing apoptosis. However, information on the underlying mechanisms controlling cancer cell growth at a molecular level remains limited. The current study analyzed the potential of colochiroside A, ds-echinoside A, philinopside E, sphingosine and stichoposide C as inhibitors for anticancer target proteins, including mouse double minute 2 homolog (MDM2) and C-X-C chemokine receptor type 4 (CXCR4)...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30250515/fibroblast-growth-factor-receptor-1-antagonism-attenuates-lipopolysaccharide-induced-activation-of-hepatic-stellate-cells-via-suppressing-inflammation
#13
Dayong Lou, Jibo Han, Liqin Zhou, Huanjie Ma, Jianjiang Xv, Junwei Shou, Zhixiu Xu, Liqin Jiang, Yuanyuan Qian
Activated hepatic stellate cells (HSCs) serve key roles in hepatic fibrosis by producing excessive extracellular matrix (ECM) components. Lipopolysaccharide (LPS) has been found to be associated with hepatic fibrogenesis through direct interactions with HSCs. Recently, the fibroblast growth factor receptor 1 (FGFR1) signalling system was identified as a key player in the process of liver fibrosis. In the present study it was evaluated whether FGFR1 mediated LPS-induced HSCs activation. In cultured cells, FGFR1 was inhibited by either siRNA silencing or by a small-molecule inhibitor in LPS-stimulated HSCs...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30233734/microrna-365-regulates-the-occurrence-and-immune-response-of-sepsis-following-multiple-trauma-via-interleukin-6
#14
Hui Gong, Xiaomin Sheng, Jianhua Xue, Dongbo Zhu
In the present study, the expression of microRNA (miR)-365 and interleukin (IL)-6 in peripheral blood mononuclear cells and serum from patients with sepsis following multiple trauma has been investigated. A total of 26 patients with sepsis following multiple trauma were included as the experimental group, whereas 21 contemporaneous patients without sepsis following multiple trauma were included as the negative control group. The expression of IL-6 mRNA and miR-365 was determined by reverse transcription-quantitative polymerase chain reaction, and western blot analysis was used to measure IL-6 protein expression...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30233733/protective-role-of-fentanyl-in-lipopolysaccharide-induced-neuroinflammation-in-bv-2-cells
#15
Jian Wang, Yingjie Jin, Jianchun Li
Neurosurgery always results in neuroinflammation, which may activate microglial cells. Previous studies have demonstrated that fentanyl could be used for the induction or maintenance of anesthesia prior to surgery. However, it is unknown if fentanyl attenuates neuroinflammation prophylactically. Cell viability in groups that were treated with different concentrations of fentanyl (0.01, 0.1, 1 or 5 µmol/l) was analyzed by an MTT assay. BV-2 microglial cells were treated with lipopolysaccharide (LPS) at a concentration of 1 µg/ml to mimic neuroinflammation in vitro ...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30233732/dysregulated-icos-proinflammatory-and-suppressive-regulatory-t-cells-in-patients-with-rheumatoid-arthritis
#16
Hong-Xia Wang, Xia Kang, Shuai Chu, Haixia Li, Xin Li, Xiaofeng Yin, Yu-Rong Qiu, Weinan Lai
Regulatory T cells (Tregs) serve an important role in the pathogenesis of rheumatoid arthritis (RA) by regulating autoimmunity and inflammation. Humans and mice contain inducible T-cell costimulator-positive (ICOS+ ) Tregs, although their role in RA is unclear. A total of 33 patients with RA and 17 normal control (NC) subjects were examined. The proportion of ICOS+ Tregs in the peripheral blood and intracellular cytokine levels in these cells were assessed using flow cytometry. The percentage of ICOS+ Tregs increased in the cohort of patients with RA compared with the NCs...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30233731/hesperidin-protects-against-il-1%C3%AE-induced-inflammation-in-human-osteoarthritis-chondrocytes
#17
Zhaozong Fu, Zhongxian Chen, Qinghua Xie, Hongjun Lei, Shanshan Xiang
Hesperidin is a vitamin P flavonoid compound primarily present in citrus fruits, which possesses an anti-inflammatory effect. The functional role of hesperidin in interleukin (IL)-1β-stimulated human osteoarthritis (OA) chondrocytes is still unknown. In the present study, anti-inflammatory effects of hesperidin in IL-1β-stimulated chondrocytes were investigated. The results demonstrated that hesperidin treatment markedly decreased nitric oxide and prostaglandin E2 production and markedly downregulated inducible nitric oxide synthase and cyclooxygenase-2 expression in IL-1β-stimulated OA chondrocytes...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30233730/clinical-characteristics-of-occluded-culprit-arteries-and-collaterals-in-patients-with-non-st-segment-elevation-myocardial-infarction-and-impact-on-clinical-outcomes
#18
Hui-Jeong Hwang, Chang-Bum Park, Jin-Man Cho, Eun-Sun Jin, Il Suk Sohn, Dong-Hee Kim, Chong-Jin Kim
The presence of an occluded culprit artery or collaterals in non-ST-segment elevation myocardial infarction (NSTEMI) is relatively common; however, limited data are available regarding their clinical significance. The aim of the current study was to determine the clinical characteristics of occluded culprit arteries and coronary collaterals in patients with NSTEMI and their impact on patient outcomes. A total of 345 patients diagnosed with NSTEMI via coronary angiography between February 2006 and May 2013 were evaluated in the present study...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30233729/mirna-146a-attenuates-inflammation-in-an-in-vitro-spinal-cord-injury-model-via-inhibition-of-tlr4-signaling
#19
Ying Tan, Longtan Yu, Chunming Zhang, Kebing Chen, Junfan Lu, Lei Tan
The present study evaluated the anti-inflammatory effect of microRNA (miR)-146a in a spinal cord injury (SCI) rat model and in vitro model, and explored possible underlying mechanisms of this effect. miR-146a expression was analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 content was measured using ELISA kits. Inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), Toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88) and phosphorylated (p)-nuclear factor (NF)-κB were measured using western blotting...
October 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30233728/combination-treatment-of-captopril-and-prazosin-to-treat-patients-with-gestational-hypertension
#20
Bo Hong, Xiang Ding, Hongmei Iia, Jianmei Zhang
Gestational hypertensive disorder is a complication of pregnancy, which adversely affects mother-child health. Captopril and prazosin are two agents that are frequently applied for the treatment of patients with gestational hypertension. However, the cooperative efficacy of captopril and prazosin has been not investigated in a previous study. In the present study, the comprehensive treatment of captopril and prazosin for the treatment of patients with gestational hypertension was investigated. A total of 324 patients with gestational hypertension were recruited to analyze the therapeutic effects of captopril and prazosin in patients with gestational hypertension...
October 2018: Experimental and Therapeutic Medicine
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