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Experimental and Therapeutic Medicine

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https://www.readbyqxmd.com/read/28596809/viscum-album-l-in-experimental-animal-tumors-a-meta-analysis
#1
Leoni Villano Bonamin, Aloisio Cunha de Carvalho, Silvia Waisse
Mistletoe (Viscum album L.) has been used as complementary anticancer treatment for ~100 years. Although the clinical efficacy of mistletoe in cancer and associated survival benefits remain contested, several studies point to its effectiveness and others have reported antitumor and immunomodulatory properties. In the present review, a search was conducted for original articles reporting the outcomes of treatments for experimental animal tumors with mistletoe. The inclusion criteria were: Publication in English, from 1996 onwards and in peer-reviewed journals included in the database PubMed...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28596808/saturated-hydrogen-saline-ameliorates-lipopolysaccharide-induced-acute-lung-injury-by-reducing-excessive-autophagy
#2
Yiming Liu, Jin Zhang
The pathogenesis of acute lung injury (ALI) induced by lipopolysaccharide (LPS) involves excessive pulmonary inflammation and oxidative stress. In turn, autophagy is associated with inflammatory diseases and organ dysfunction, and studies have demonstrated that LPS treatment may trigger autophagy. Thus, excessive autophagy may stimulate the strong inflammatory response observed in the development of LPS-induced ALI. Saturated hydrogen saline may alleviate LPS-induced ALI by inhibiting autophagy, however its underlying mechanisms of action remain unknown...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588691/chronic-hepatitis-b-patients-with-high-liver-fibrosis-levels-should-receive-antiviral-treatment
#3
Xu Li, Qinglong Jin, Hongqin Xu, Zetian Zhang, Hongjie Zhou, Dongqing Yan, Dongmei Li, Pujun Gao, Junqi Niu
The present study aimed to evaluate improvements in liver stiffness (LS) measured by transient elastography (TE) and associated factors in Chinese patients with chronic hepatitis B (CHB) treated with entecavir (ETV). A total of 190 consecutive CHB patients who received entecavir therapy and two LS measurements (LSMs) were enrolled in this retrospective study (average age, 47 years; 137 males [72.1%]), including 111 patients without liver cirrhosis (group 0) and 79 patients with liver cirrhosis (group 1). Each patient received LSM twice with an interval of six months...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588690/insight-into-the-binding-interaction-of-kaempferol-7-o-%C3%AE-l-rhamnopyranoside-with-human-serum-albumin-by-multiple-fluorescence-spectroscopy-and-molecular-modeling
#4
Wenting Zhang, Chun Chen, Chunping Zhang, Jingyu Duan, Huankai Yao, Yan Li, Aiguo Meng, Jun Shi
Human serum albumin (HSA) is a transporting protein that has multiple functions. The binding interaction between HSA and small molecules affects its function and efficacy of small molecules. The present study reports that kaempferol-7-O-α-L-rhamnopyranoside (KR) interacts with HSA as indicated by multiple fluorescence spectroscopy and molecular modeling. KR can quench the intrinsic fluorescence of HSA through the formation of a KR-HSA complex in a static manner. In addition, the binding site is located in subdomain IIA as confirmed by competitive experiments using site-specific warfarin and ibuprofen, and the driving forces include hydrogen bonds, van der Waals forces and electrostatic interaction derived from a thermodynamic analysis...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588689/safety-of-neural-stem-cell-transplantation-in-patients-with-severe-traumatic-brain-injury
#5
Zhigang Wang, Yong Luo, Lvan Chen, Wu Liang
Neural stem cell (NSC) therapy is a promising treatment for traumatic brain injury (TBI). In addition, mesenchymal stem cells (MSCs) have been investigated for the treatment of TBI due to their functions in neural regeneration and their neurotrophic effect. In the present study, the safety, feasibility and biological effects of autologous MSC-derived NSC-like cell transplantation were investigated in 10 patients with severe TBI. All patients received intravenous or intrathecal injections of human NSC-like cells and were evaluated with physical and neurological examinations, routine laboratory tests and neuroradiological findings...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588688/combined-effects-of-long-pulsed-neodymium-yttrium-aluminum-garnet-laser-diprospan-and-5-fluorouracil-in-the-treatment-of-keloid-scars
#6
Xiao-E Chen, Juan Liu, Afzaal Ahmed Bin Jameel, Maya Valeska, Jia-An Zhang, Yang Xu, Xing-Wu Liu, Hong Zhou, Dan Luo, Bing-Rong Zhou
Keloids are benign tumors that originate from scar tissues, but they usually overgrow beyond the original wounds. In a three-month single-center clinical trial, 69 patients were randomly divided into three groups. Patients in group 1 were treated with intralesional injection of diprospan (2 mg betamethasone disodium phosphate and 5 mg betamethasone dipropionate in 1 ml) with one-month intervals for three months. Patients in groups 2 and 3 were injected with a combination of 0.5 ml 5-fluorouracil (5-FU; 25 mg/ml) and diprospan as above for three months also...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588687/retroperitoneal-fibrosis-and-constrictive-pericarditis-igg4-related-diseases-a-case-report
#7
Brankica Terzic, Marijan Spasic, Predrag Djuric, Vladimir Vasiljevic, Slavica Radjen, Mirjana Mijuskovic
Retroperitoneal fibrosis (RPF) is a rare disease characterized by infiltration of inflammatory cells and deposition of thickened fibrous tissues. The present study presents the case of a 53-year-old patient treated for generalized weakness and fatigue for 1 year prior to hospitalization. A cardiac ultrasound revealed pericardial effusion that required pericardiocentesis, during which 1,400 ml serous fluid with the characteristics of an exudate was aspirated. A pericardiectomy was performed due to persistent effusion and histological examination indicated pericardial fibrosis...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588686/effect-of-continuous-renal-replacement-therapy-on-kidney-injury-molecule-1-and-neutrophil-gelatinase-associated-lipocalin-in-patients-with-septic-acute-kidney-injury
#8
Yiming Shao, Yinqiang Fan, Yuliu Xie, Lu Yin, Yuanli Zhang, Liehua Deng, Xiaocong Sun, Xin Shao, Xinzhang Tan, Junbing He, Shiman Zhao
Kidney injury molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (NGAL) have been investigated as biomarkers for acute kidney injury (AKI). However, they are seldom investigated in patients with septic AKI treated with continuous renal replacement therapy (CRRT). The aim of the present study was to investigate the therapeutic effectiveness and possible mechanisms of CRRT in septic AKI by observing the changes in Kim-1 and NGAL levels. A group of 38 patients with septic AKI was randomly divided into the conventional drug treatment group (group A) and the CRRT group (group B)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588685/lumbar-spinal-intradural-neurocysticercosis-a-case-report
#9
Shizhong Zhang, Yanyan Hu, Zhen Li, Li Zhao, Zhigang Wang
Neurocysticercosis is a parasitic disease that results from the larvae of Taenia solium. While neurocysticercosis is considered as the most common parasitic infection of the nervous system, spinal neurocysticercosis is rare. The present case study investigated a 59-year-old woman, who was admitted to our hospital with pain in the bilateral lower limbs and urinary complaints in the form of straining of micturition with increasing frequency. Magnetic resonance imaging revealed an intradural extramedullary lesion extending from L1/2 to S1 of the spine...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588684/successful-treatment-of-granulomatosis-with-polyangiitis-with-hydropneumothorax-using-corticosteroids-and-immunosuppressant
#10
Xu-Hua Shi, Yong-Feng Zhang, Yue-Wu Lu
Pneumothorax and pleural effusion is a rare and serious complication of granulomatosis with polyangiitis (GPA). The present study reported a case with a history of sinusitis for 20 years, dry cough for three years and exacerbated purulent nasal discharge and recurrent skin ulcers for two years. The patient experienced sudden difficulty in breathing two months prior to presentation. Lung computed tomography (CT) showed multiple bilateral lung nodules and cavitary nodules as well as right hydropneumothorax. Paranasal sinus CT showed soft tissue infiltration...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588683/expression-and-immunogenicity-of-ny-eso-1-in-colorectal-cancer
#11
Ya Li, Ruifeng Song, Xinqiang Li, Feng Xu
Serum assays of NY-ESO-1 antibodies provide a guide to discriminate between patients who suffer from different types of cancer. In the present study, the expression of NY-ESO-1 was detected with the aim to identify a novel tumor antigen in colorectal cancer (CRC). Sera were obtained from 89 healthy individuals and 236 patients with CRC with stage I, II, III and IV tumors. The NY-ESO-1 autoantibody levels were determined using an enzyme-linked immunosorbent assay. The mRNA and protein expression levels of NY-ESO-1 were detected using reverse transcription-polymerase chain reaction and immunohistochemistry, respectively, in 60 CRC and paired adjacent non-tumor tissues...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588682/comparison-of-biological-characteristics-of-nucleus-pulposus-mesenchymal-stem-cells-derived-from-non-degenerative-and-degenerative-human-nucleus-pulposus
#12
Zhiwei Jia, Pushan Yang, Yaohong Wu, Yong Tang, Yachao Zhao, Jianhong Wu, Deli Wang, Qing He, Dike Ruan
Cell therapy using mesenchymal stem cells provides a promising approach for the treatment of intervertebral disc degeneration (IDD). In recent years, human nucleus pulposus mesenchymal stem cells (NPMSCs) have been identified in nucleus pulposus tissue and displayed great potential for the regeneration of IDD. However, biological differences between non-degenerative and degenerative nucleus pulposus-derived NPMSCs have remained to be defined. The aim of the present study was to compare the biological characteristics of human NPMSCs derived from non-degenerative and degenerative nucleus pulposus...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588681/effects-of-gui-zhu-yi-kun-formula-on-the-p53-ampk-pathway-of-autophagy-in-granulosa-cells-of-rats-with-polycystic-ovary-syndrome
#13
Yu Xing, Yan-Xia Liu, Xin Liu, Shu-Lin Wang, Ping Li, Xiao-Hua Lin, Cong-Lu Sui, Cai Xu, Bing Qi, Qing Tong
The aim of the present study was to investigate the molecular mechanism associated with the traditional Chinese medicine formula Gui Zhu Yi Kun formula (GZYKF), in the treatment of polycystic ovary syndrome (PCOS). In this study, granulosa cells (GCs) of rats with PCOS were cultured and treated with testosterone propionate (TP) alone or with serum from rats treated with different doses of GZYKF. The effect of TP on cell growth was assayed using the MTT method. Expression levels of Beclin-1, light chain (LC)3, mechanistic target of rapamycin (mTOR), tumor suppressor p53 (p53), adenosine monophosphate-activated protein kinase (AMPK), sestrin2 and tuberous sclerosis protein 1/2 were evaluated using quantitative polymerase chain reaction and western blotting...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588680/early-clinical-characteristics-of-bacterial-endophthalmitis-in-retinopathy-of-prematurity-after-intravitreal-bevacizumab-injection-a-case-report
#14
Jianxun Wang, Daoman Xiang
Intravitreal bevacizumab injection (IVB) is emerging as a safe and effective therapy for retinopathy of prematurity (ROP); however, follow-up investigations after IVB have indicated that endophthalmitis, a rare and devastating complication, may develop. The present study reports a case of an infant with ROP who developed endophthalmitis after IVB infection. The infant was administered with an intravitreal injection of broad-spectrum antibiotics to treat the endophthalmitis. A favorable anatomic outcome was achieved after follow-up...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588679/microrna-664-enhances-proliferation-migration-and-invasion-of-lung-cancer-cells
#15
Xinhai Zhu, Sheng Ju, Feng Yuan, Guoping Chen, Yue Shu, Chuanchuan Li, Yanhui Xu, Jing Luo, Lilong Xia
Altered microRNA (miR) expression serves an important role in the development and progression of lung cancer. In the present study, the effect of miR-664 on proliferation, migration and invasion of lung cancer cells was assessed. The proliferation of lung cancer cells with an overexpression of miR-664 was examined via MTT assay. The Caspase-Glo3/7 assay was used to examine the effect of miR-664 on cisplatin-induced apoptosis in lung cancer cells. The migration and invasion of lung cancer cells were assessed by Transwell migration and matrigel invasion assays...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588678/mechanism-of-n-acetyl-cysteine-inhibition-on-the-cytotoxicity-induced-by-titanium-dioxide-nanoparticles-in-jb6-cells-transfected-with-activator-protein-1
#16
Hongbo Shi, Yuanliang Gu, Zhenhua Xie, Qi Zhou, Guochuan Mao, Xialu Lin, Kui Liu, Yu Liu, Baobo Zou, Jinshun Zhao
The present study investigated the mechanism of N-acetyl-cysteine (NAC) inhibition on the cytotoxicity induced by titanium dioxide (TiO2) nanoparticles (NPs) using murine epidermal JB6 cells transfected with activator protein-1 (AP-1), JB6-AP-1 cells. Confocal microscopy was performed to localize TiO2 NPs in cultured cells. The level of reactive oxygen species (ROS) present in cells was evaluated by staining with 2',7'-dichlorodihydrofluorescein diacetate and dihydroethidium. AP-1 gene expression levels in the cells were detected using the luciferase assay...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588677/comparative-study-of-conventional-us-contrast-enhanced-us-and-enhanced-mr-for-the-follow-up-of-prostatic-radiofrequency-ablation
#17
Chao Feng, Bin Hu, Bing Hu, Lei Chen, Jia Li, Jin Huang
The aim of the present study was to evaluate and compare the effectiveness of different imaging methods during follow-up of prostatic radiofrequency ablation. Prostatic radiofrequency ablation (RFA) was performed in 20 healthy beagle dogs. Various imaging examinations were used to monitor the results of RFA, including conventional ultrasound (US), contrast enhanced ultrasound (CEUS) and enhanced magnetic resonance (MR). Imaging exams were performed at five phases: Immediately following RFA, one week later, one month later, three months later and six months later...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588676/xuebijing-injection-attenuates-pulmonary-injury-by-reducing-oxidative-stress-and-proinflammatory-damage-in-rats-with-heat-stroke
#18
Yi Chen, Huasheng Tong, Zhiguo Pan, Dongxin Jiang, Xinqin Zhang, Junming Qiu, Lei Su, Minzhou Zhang
The present study aimed to investigate the protective effect of Xuebijing injection (XBJ) on lung injury in heat-stroke rats and the underlying mechanisms. In total, 54 rats were randomly assigned to non-thermal, saline vehicle and XBJ groups. The rectal temperature (Tc), mean arterial pressure (MAP) and respiratory rate (RR) of the rats were recorded. The time-point of heat stroke and the time of survival were assessed, and indicators of arterial blood gas were regularly measured from 0 to 60 min. The concentration of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-10 was also determined...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588675/fragmented-qrs-complex-is-a-prognostic-marker-of-microvascular-reperfusion-and-changes-in-lv-function-occur-in-patients-with-st-elevation-myocardial-infarction-who-underwent-primary-percutaneous-coronary-intervention
#19
Ruoxi Zhang, Shuyuan Chen, Qi Zhao, Meng Sun, Bo Yu, Jingbo Hou
The present study aimed to investigate the in-hospital and long-term prognostic value of fragmented QRS complex (fQRS) for microvascular reperfusion and changes in left ventricular (LV) function in patients with ST elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). A total of 216 patients with STEMI undergoing primary PCI were included in the current study. Patients were divided into two groups based on the presence (n=126) or absence (n=90) of fQRS following electrocardiograms (ECGs) on admission...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28588674/resveratrol-ameliorates-diabetic-nephropathy-in-rats-through-negative-regulation-of-the-p38-mapk-tgf-%C3%AE-1-pathway
#20
Yuan Qiao, Ke Gao, Yangwei Wang, Xueliang Wang, Bo Cui
Resveratrol (RSV) has been shown to have a renoprotective effect against diabetic nephropathy, but the underlying mechanisms of this have not been fully elucidated. The aim of the current study was to explore the mechanisms responsible for the therapeutic effects of RSV in rat mesangial cells in vitro and in a rat model of diabetic nephropathy. The viability of CRL-2573 rat mesangial cells and their expression levels of p38, phosphorylated (p)-p38, transforming growth factor beta 1 (TGF-β1) and fibronectin were assessed in response to treatment with high glucose, with or without RSV...
June 2017: Experimental and Therapeutic Medicine
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