journal
MENU ▼
Read by QxMD icon Read
search

Clinical Epidemiology

journal
https://www.readbyqxmd.com/read/28814899/irritable-bowel-symptoms-and-the-development-of-common-mental-disorders-and-functional-somatic-syndromes-identified-in-secondary-care-a-long-term-population-based-study
#1
Chalotte Heinsvig Poulsen, Lene Falgaard Eplov, Carsten Hjorthøj, Marie Eliasen, Sine Skovbjerg, Thomas Meinertz Dantoft, Andreas Schröder, Torben Jørgensen
OBJECTIVE: Irritable bowel syndrome (IBS) is associated with mental vulnerability, and half of patients report comorbid somatic and mental symptoms. We aimed to investigate the relationship between an IBS symptom continuum and the subsequent development of common mental disorders (CMDs) and functional somatic syndromes (FSSs). METHODS AND STUDY DESIGN: A longitudinal population-based study comprising two 5-year follow-up studies, Dan-MONICA 1 (1982-1987) and Inter99 (1999-2004), recruited from the western part of Copenhagen County...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28790866/incidence-clinical-presentation-and-outcome-of-hiv-1-associated-cryptococcal-meningitis-during-the-highly-active-antiretroviral-therapy-era-a-nationwide-cohort-study
#2
Madeleine Touma, Line D Rasmussen, Raquel Martin-Iguacel, Frederik Neess Engsig, Nina Breinholt Stærke, Mette Stærkind, Niels Obel, Magnus Glindvad Ahlström
BACKGROUND: Human immunodeficiency virus (HIV) infection with advanced immunosuppression predisposes to cryptococcal meningitis (CM). We describe the incidence, clinical presentation, and outcome of CM in HIV-infected individuals during the highly active antiretroviral therapy (HAART) era. METHODS: A nationwide, population-based cohort of HIV-infected individuals was used to estimate incidence and mortality of CM including risk factors. A description of neurological symptoms of CM at presentation and follow-up in the study period 1995-2014 was included in this study...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28761377/fecal-occult-blood-versus-dna-testing-indirect-comparison-in-a-colorectal-cancer-screening-population
#3
Hermann Brenner, Hongda Chen
BACKGROUND: A multitarget stool DNA test (MSDT) that showed higher sensitivity but lower specificity than a fecal immunochemical test (FIT) for hemoglobin in one recent study from the US and Canada, is increasingly used for colorectal cancer (CRC) screening, despite its ~20-fold higher costs compared to FITs. We aimed to assess diagnostic performance of a quantitative FIT in an independent study among participants of screening colonoscopy and to compare it with the previously reported performance of MSDT...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28744162/validity-of-an-automated-algorithm-using-diagnosis-and-procedure-codes-to-identify-decompensated-cirrhosis-using-electronic-health-records
#4
Mei Lu, Wadih Chacra, David Rabin, Loralee B Rupp, Sheri Trudeau, Jia Li, Stuart C Gordon
Viral hepatitis-induced cirrhosis can progress to decompensated cirrhosis. Clinical decompensation represents a milestone event for the patient with cirrhosis, yet there remains uncertainty regarding precisely how to define this important phenomenon. With the development of broader treatment options for cirrhotic hepatitis patients, efficient identification of liver status before evolving to decompensated cirrhosis could be life-saving, but research on the topic has been limited by inconsistencies across studies, populations, and case-confirmation methods...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28740433/erratum-validation-of-second-trimester-miscarriages-and-spontaneous-deliveries-corrigendum
#5
(no author information available yet)
[This corrects the article on p. 517 in vol. 7, PMID: 26715859.].
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28740432/the-criterion-validity-of-the-web-based-major-depression-inventory-when-used-on-clinical-suspicion-of-depression-in-primary-care
#6
Marie Germund Nielsen, Eva Ørnbøl, Per Bech, Mogens Vestergaard, Kaj Sparle Christensen
BACKGROUND: The Major Depression Inventory (MDI) is widely used in Danish general practice as a screening tool to assess depression in symptomatic patients. Nevertheless, no validation studies of the MDI have been performed. The aim of this study was to validate the web-based version of the MDI against a fully structured telephone interview in a population selected on clinical suspicion of depression (ie, presence of two or three core symptoms of depression) in general practice. MATERIALS AND METHODS: General practitioners (GPs) invited consecutive persons suspected of depression to complete the web-based MDI in a primary care setting...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28721099/sociodemographic-characteristics-of-nonparticipants-in-the-danish-colorectal-cancer-screening-program-a-nationwide-cross-sectional-study
#7
Mette Bach Larsen, Ellen M Mikkelsen, Morten Rasmussen, Lennart Friis-Hansen, Anders U Ovesen, Hans Bjarke Rahr, Berit Andersen
INTRODUCTION: Fecal occult blood tests are recommended for colorectal cancer (CRC) screening in Europe. Recently, the fecal immunochemical test (FIT) has come into use. Sociodemographic differences between participants and nonparticipants may be less pronounced when using FIT as there are no preceding dietary restrictions and only one specimen is required. The aim of this study was to examine the associations between sociodemographic characteristics and nonparticipation for both genders, with special emphasis on those who actively unsubscribe from the program...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28670142/prevalence-of-hypercalcemia-of-malignancy-among-pediatric-cancer-patients-in-the-uk-clinical-practice-research-datalink-database
#8
Susan Jick, Lin Li, Victor M Gastanaga, Alexander Liede, Rohini K Hernandez
BACKGROUND: The reported proportion of cancer patients who experience hypercalcemia of malignancy (HCM) is low, particularly in the pediatric population, ranging between <1% and 5%. HCM can be observed with any type of tumor in children and occurs most commonly with leukemia. While HCM is a potentially fatal condition, the prevalence of HCM is not well understood in pediatric cancer patients. METHODS: Using the UK Clinical Practice Research Datalink, we identified pediatric cancer patients with recorded corrected serum calcium (CSC) from 2003 through 2014...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28652815/effect-modification-interaction-and-mediation-an-overview-of-theoretical-insights-for-clinical-investigators
#9
Priscila Corraini, Morten Olsen, Lars Pedersen, Olaf M Dekkers, Jan P Vandenbroucke
We revisited the three interrelated epidemiological concepts of effect modification, interaction and mediation for clinical investigators and examined their applicability when using research databases. The standard methods that are available to assess interaction, effect modification and mediation are explained and exemplified. For each concept, we first give a simple "best-case" example from a randomized controlled trial, followed by a structurally similar example from an observational study using research databases...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28652814/return-to-work-for-patients-with-diffuse-large-b-cell-lymphoma-and-transformed-indolent-lymphoma-undergoing-autologous-stem-cell-transplantation
#10
Bente Arboe, Maja Halgren Olsen, Jette Soenderskov Goerloev, Anne Katrine Duun-Henriksen, Christoffer Johansen, Susanne Oksbjerg Dalton, Peter de Nully Brown
BACKGROUND: Autologous stem cell transplantation (ASCT) is the standard treatment for patients with relapsed diffuse large B-cell lymphoma (DLBCL) or transformed indolent lymphoma (TIL). The treatment is mainly considered for younger patients still available for the work market. In this study, social outcomes after ASCT in terms of return to work (RTW) are described. PATIENTS AND METHODS: Information from national administrative registers was combined with clinical information on patients, who received ASCT for relapse of DLBCL or TIL between 2000 and 2012...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28652813/charlson-comorbidity-index-derived-from-chart-review-or-administrative-data-agreement-and-prediction-of-mortality-in-intensive-care-patients
#11
Knut Stavem, Henrik Hoel, Stein Arve Skjaker, Rolf Haagensen
PURPOSE: This study compared the Charlson comorbidity index (CCI) information derived from chart review and administrative systems to assess the completeness and agreement between scores, evaluate the capacity to predict 30-day and 1-year mortality in intensive care unit (ICU) patients, and compare the predictive capacity with that of the Simplified Acute Physiology Score (SAPS) II model. PATIENTS AND METHODS: Using data from 959 patients admitted to a general ICU in a Norwegian university hospital from 2007 to 2009, we compared the CCI score derived from chart review and administrative systems...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28579835/transmission-of-health-care-associated-infections-from-roommates-and-prior-room-occupants-a-systematic-review
#12
REVIEW
Bevin Cohen, Catherine Crawford Cohen, Borghild Løyland, Elaine L Larson
Pathogens that cause health care-associated infections (HAIs) are known to survive on surfaces and equipment in health care environments despite routine cleaning. As a result, the infection status of prior room occupants and roommates may play a role in HAI transmission. We performed a systematic review of the literature evaluating the association between patients' exposure to infected/colonized hospital roommates or prior room occupants and their risk of infection/colonization with the same organism. A PubMed search for English articles published in 1990-2014 yielded 330 studies, which were screened by three reviewers...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28579834/hypoglycemia-a-review-of-definitions-used-in-clinical-trials-evaluating-antihyperglycemic-drugs-for-diabetes
#13
REVIEW
Chakrapani Balijepalli, Eric Druyts, Gaye Siliman, Michel Joffres, Kristian Thorlund, Edward J Mills
OBJECTIVE: To understand the severity and potential impact of heterogeneity in definitions of hypoglycemia used in diabetes research, we aimed to review the hypoglycemia definitions adopted in randomized controlled trials (RCTs). METHODS: We reviewed 109 RCTs included in the Canadian Agency for Drugs and Technologies in Health reports for the second- and third-line therapy for the patients with type 2 diabetes (T2D). RESULTS: Nearly 60% (n=66) of the studies reviewed presented the definitions for overall hypoglycemia, and another 20% (n=22) of the studies reported the results for hypoglycemia but did not report a definition...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28546772/the-impact-of-socioeconomic-status-and-multimorbidity-on-mortality-a-population-based-cohort-study
#14
Nikoline Lund Jensen, Henrik Søndergaard Pedersen, Mogens Vestergaard, Stewart W Mercer, Charlotte Glümer, Anders Prior
OBJECTIVE: Multimorbidity (MM) is more prevalent among people of lower socioeconomic status (SES), and both MM and SES are associated with higher mortality rates. However, little is known about the relationship between SES, MM, and mortality. This study investigates the association between educational level and mortality, and to what extent MM modifies this association. METHODS: We followed 239,547 individuals invited to participate in the Danish National Health Survey 2010 (mean follow-up time: 3...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28533698/use-of-the-medicare-database-in-epidemiologic-and-health-services-research-a-valuable-source-of-real-world-evidence-on-the-older-and-disabled-populations-in-the-us
#15
REVIEW
Katherine E Mues, Alexander Liede, Jiannong Liu, James B Wetmore, Rebecca Zaha, Brian D Bradbury, Allan J Collins, David T Gilbertson
Medicare is the federal health insurance program for individuals in the US who are aged ≥65 years, select individuals with disabilities aged <65 years, and individuals with end-stage renal disease. The Centers for Medicare and Medicaid Services grants researchers access to Medicare administrative claims databases for epidemiologic and health outcomes research. The data cover beneficiaries' encounters with the health care system and receipt of therapeutic interventions, including medications, procedures, and services...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28503076/positive-predictive-value-of-peptic-ulcer-diagnosis-codes-in-the-danish-national-patient-registry
#16
Søren Viborg, Kirstine Kobberøe Søgaard, Peter Jepsen
BACKGROUND: Diagnoses of peptic ulcer are registered in the Danish National Patient Registry (DNPR) for administrative as well as research purposes, but it is unknown whether the coding validity depends on the location of the ulcer. OBJECTIVE: To validate the International Classification of Diseases, 10(th) revision diagnosis codes of peptic ulcer in the DNPR by estimating positive predictive values (PPVs) for gastric and duodenal ulcer diagnoses. METHODS: We identified all patients registered with a hospital discharge diagnosis of peptic ulcer from Aarhus University Hospital, Denmark, in 1995-2006...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28496365/prevalence-and-prognosis-of-stress-disorders-a-review-of-the-epidemiologic-literature
#17
REVIEW
Jaimie L Gradus
Given the ubiquity of traumatic events, it is not surprising that posttraumatic stress disorder (PTSD) - a common diagnosis following one of these experiences - is characterized as conferring a large burden for individuals and society. Although there is recognition of the importance of PTSD diagnoses throughout psychiatry, the literature on other diagnoses one may receive following a stressful or traumatic event is scant. This review summarizes the literature on stress disorders (classified according to the International Classification of Diseases, 10th Edition [ICD-10]), including acute stress reaction, PTSD, adjustment disorder and unspecified stress reactions...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28490904/clinical-epidemiology-in-the-era-of-big-data-new-opportunities-familiar-challenges
#18
Vera Ehrenstein, Henrik Nielsen, Alma B Pedersen, Søren P Johnsen, Lars Pedersen
Routinely recorded health data have evolved from mere by-products of health care delivery or billing into a powerful research tool for studying and improving patient care through clinical epidemiologic research. Big data in the context of epidemiologic research means large interlinkable data sets within a single country or networks of multinational databases. Several Nordic, European, and other multinational collaborations are now well established. Advantages of big data for clinical epidemiology include improved precision of estimates, which is especially important for reassuring ("null") findings; ability to conduct meaningful analyses in subgroup of patients; and rapid detection of safety signals...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28490903/cardiovascular-risks-in-smokers-treated-with-nicotine-replacement-therapy-a-historical-cohort-study
#19
Jens Dollerup, Jørgen Vestbo, Tarita Murray-Thomas, Alan Kaplan, Richard J Martin, Emilio Pizzichini, Marcia M M Pizzichini, Anne Burden, Jessica Martin, David B Price
BACKGROUND: Previous research suggests exposure to nicotine replacement therapy (NRT) may be associated with an increased risk of cardiovascular disease (CVD). METHODS: Using data from the United Kingdom's Clinical Practice Research Datalink, this study aimed to evaluate CVD events and survival among individuals who attempted smoking cessation with the support of NRT compared with those aided by smoking cessation advice only. We studied CVD outcomes over 4 and 52 weeks in 50,214 smokers attempting to quit - 33,476 supported by smoking cessation advice and 16,738 with the support of NRT prescribed by their primary care physician...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28442934/effect-of-glomerular-filtration-rate-at-dialysis-initiation-on-survival-in-patients-with-advanced-chronic-kidney-disease-what-is-the-effect-of-lead-time-bias
#20
Cynthia J Janmaat, Merel van Diepen, Raymond T Krediet, Marc H Hemmelder, Friedo W Dekker
PURPOSE: Current clinical guidelines recommend to initiate dialysis in the presence of symptoms or signs attributable to kidney failure, often with a glomerular filtration rate (GFR) of 5-10 mL/min/1.73 m(2). Little evidence exists about the optimal kidney function to start dialysis. Thus far, most observational studies have been limited by lead-time bias. Only a few studies have accounted for lead-time bias, and showed contradictory results. We examined the effect of GFR at dialysis initiation on survival in chronic kidney disease patients, and the role of lead-time bias therein...
2017: Clinical Epidemiology
journal
journal
43037
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"