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Thoracic Cancer

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https://www.readbyqxmd.com/read/28440945/heterogeneity-in-esophageal-and-gastric-cardia-precursor-progression-during-six-year-endoscopic-surveillance-after-population-based-screening-in-a-chinese-high-risk-region
#1
Denggui Wen, Liwei Zhang, Xiaoling Wang, Xiaoduo Wen, Yi Yang, Yuetong Chen, Guiying Wang, Kohei Akazawa, Shijie Wang, Baoen Shan
BACKGROUND: The study was conducted to examine esophageal and gastric cardia precursor progression. METHODS: After population-based baseline screening, 145 precursor and 335 chronic inflammation cases were endoscopically surveyed for six years. RESULTS: Surveillance of interval and baseline diagnoses for 18 severe dysplasia (SD) cases later detected were: 13, 23, 39, and 44 months since a diagnosis of chronic inflammation in four cases; 6, 6, 6, 11, 13, 16, 16, and 23 months since mild dysplasia (mD) diagnoses in eight; and 6, 9, 10, 13, 18, and 48 months since moderate dysplasia (MD) diagnoses in six...
April 25, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28437026/analyzing-epidermal-growth-factor-receptor-mutation-status-changes-in-advanced-non-small-cell-lung-cancer-at-different-sampling-time-points-of-blood-within-one%C3%A2-day
#2
Jin Wang, Hua Bai, Chaoyu Hong, Jie Wang, Tong-Hua Mei
BACKGROUND: We investigated whether different sampling time-points within one day would influence epidermal growth factor receptor mutation (EGFRm) status in plasma and evaluated the clinical outcomes according to the quantity analysis of EGFRm in circulating tumor DNA (ctDNA) in non-small-cell lung cancer (NSCLC). METHODS: EGFR-tyrosine kinase inhibitor naïve advanced NSCLC patients who carried EGFRm in both tissues and ctDNA were enrolled in this study. Plasma samples were collected at three time-points within one day (at 8 am, 11 am and 2 pm) for EGFRm analysis by droplet digital PCR...
April 24, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28436174/endobronchial-and-transbronchial-biopsy-experience-a-united-kingdom-survey
#3
REVIEW
Janet Fallon, Andrew R L Medford
BACKGROUND: Trainees are performing fewer bronchoscopies as a result of the increased use of endobronchial ultrasound-guided transbronchial needle aspiration. Workforce planning and changes in trainee working patterns may also have compounded this situation. We investigated current trends in endobronchial biopsy (EBB) and transbronchial biopsy (TBB) training and competency in respiratory trainees and consultants across the United Kingdom. METHODS: We performed a national survey and received 131 online responses from 58 consultants and 73 registrars across 13 United Kingdom deaneries...
April 24, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28436173/relationship-between-endobronchial-ultrasound-guided-ebus-transbronchial-needle-aspiration-utility-and-computed-tomography-staging-node-size-at-ebus-and-positron-emission-tomography-scan-node-standard-uptake-values-a-retrospective-analysis
#4
Clare Marchand, Andrew R L Medford
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) diagnoses and stages mediastinal lymph node pathology. This retrospective study determined the relationship between EBUS-TBNA utility and non-small cell lung cancer (NSCLC) stage, lymph node size, and positron emission tomography (PET) standard uptake values (SUV), and the utility of neck ultrasound in bulky mediastinal disease. METHODS: Data of 284 consecutive patients who had undergone EBUS-TBNA was collected...
April 24, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28407362/traffic-related-air-pollution-and-lung-cancer-a-meta-analysis
#5
LETTER
Weisan Zhang, Fengtan Li, Wenyuan Gao
No abstract text is available yet for this article.
April 13, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28407361/influence-of-tanshinone-iia-on-apoptosis-of-human-esophageal-carcinoma-eca-109-cells-and-its-molecular-mechanism
#6
Yan Zhang, Shan Li, Hang He, Qianqian Han, Baiyan Wang, Yanqin Zhu
BACKGROUND: Previous studies have shown that Tanshinone (Tan) IIA exerts obvious antitumor efficacy; however, its molecular mechanism remains unclear. This study was conducted to identify the influence of Tan IIA on Eca-109 cell apoptosis, explore its molecular mechanism, and provide a theoretical basis for clinical application. METHODS: Eca-109 cells were cultured in vitro and treated with different concentrations of Tan IIA. Morphologic changes were viewed under inverted fluorescence microscope with dual acridine orange/ethidium bromide staining assay...
April 13, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28402606/timing-of-paclitaxel-treatment-in-pre-operative-or-post-operative-does-not-affect-survival-in-breast-cancer-patients
#7
Jiayu Wang, Shanshan Chen, Binghe Xu, Peng Yuan, Fei Ma, Qing Li, Pin Zhang, Ruigang Cai, Ying Fan, Yang Luo, Qiao Li
BACKGROUND: Two epirubicin and paclitaxel-based neoadjuvant chemotherapy regimens were compared in breast cancer patients. METHODS: We enrolled 309 breast cancer patients who received two types of regimens: cyclophosphamide + epirubicin dose-dense neoadjuvant chemotherapy followed by sequential postoperative paclitaxel single-drug medication, and paclitaxel + epirubicin standard neoadjuvant chemotherapy followed by two cycles of the same chemotherapy after surgery...
April 12, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28383810/secondary-biopsy-of-non-oncogenic-driven-lung-cancer-may-reveal-a-clinically-sensible-histologic-change-a-brief-report-of-two-paradigmatic-cases
#8
Maria C Mengoli, Giulia Orsi, Filippo Lococo, Giulia Grizzi, Fausto Barbieri, Federica Bertolini, Giulio Rossi, Silvia Novello
After an initial benefit, non-small-cell lung cancer (NSCLC) patients receiving therapy with tyrosine kinase inhibitors develop drug resistance through a variety of mechanisms. Among these, tumor histology changes are a mechanism of acquired resistance in epidermal growth factor receptor-mutated and anaplastic lymphoma kinase-rearranged NSCLC cases. The current availability of therapeutic approaches to overcome tyrosine kinase inhibitor resistance in oncogenic-driven lung cancers justifies secondary tumor biopsy in these patients...
April 6, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28383802/computed-tomography-and-clinical-features-associated-with-epidermal-growth-factor-receptor-mutation-status-in-stage-i-ii-lung-adenocarcinoma
#9
Jiawei Zou, Tangfeng Lv, Suhua Zhu, Zhenfeng Lu, Qin Shen, Leilei Xia, Jie Wu, Yong Song, Hongbing Liu
BACKGROUND: The relationship between epidermal growth factor receptor (EGFR) gene mutation status, preoperative computed tomography (CT), and clinical features in patients with small peripheral lung adenocarcinoma (<3 cm) was investigated. METHODS: We included 209 patients who underwent surgical resection for stage I or II lung adenocarcinoma at Nanjing General Hospital between December 2010 and May 2016. 171 cases of patients underwent a pretreatment chest CT...
April 6, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28371390/video-assisted-thoracoscopy-in-the-management-of-intrapleural-extravasation-of-cytotoxic-chemotherapy
#10
Victor J Aguirre, Dylan Barnett, Nikki Burdett, Rohit Joshi, Fabiano F Viana
The extravasation of cytotoxic agents into subcutaneous tissue is a serious complication of chemotherapy. Unfortunately, if such extravasation occurs into the pleural space, limited data is available to guide appropriate management. We present the first report in the literature of video-assisted thoracoscopy combined with a topoisomerase II inhibitor and iron chelator, dexrazoxane, in the successful management of this complication.
March 31, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28371058/development-of-a-prognosis-prediction-model-incorporating-genetic-polymorphism-with-pathologic-stage-in-stage-i-non-small-cell-lung-cancer-a-multicenter-study
#11
Won Kee Lee, Shin Yup Lee, Jin Eun Choi, Yangki Seok, Eung Bae Lee, Hyun Cheol Lee, Hyo-Gyoung Kang, Seung Soo Yoo, Myung Hoon Lee, Sukki Cho, Sanghoon Jheon, Young Chul Kim, In Jae Oh, Kook Joo Na, Chi Young Jung, Chang-Kwon Park, Mi-Hyun Kim, Min Ki Lee, Jae Yong Park
BACKGROUND: This multicenter study was performed to develop a prognosis-prediction model incorporating genetic polymorphism with pathologic stage for surgically treated non-small cell lung cancer (NSCLC) patients. METHODS: A replication study including 720 patients and a panel of eight single nucleotide polymorphisms (SNPs), which predicted the prognosis of surgically treated NSCLC in our previous study, was conducted. Using the combined cohort of current and previous studies including 1534 patients, a nomogram for predicting overall survival was made using Cox proportional hazards regression...
March 31, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28371397/delayed-pseudoprogression-of-lung-adenocarcinoma-accompanied-with-interstitial-lung-disease-during-chemotherapy-after-nivolumab-treatment
#12
Toru Kumagai, Madoka Kimura, Takako Inoue, Motohiro Tamiya, Kazumi Nishino, Fumio Imamura
A 62-year-old Japanese female with primary lung adenocarcinoma received seven cycles of nivolumab as an eighth line of chemotherapy until she presented with hemoptysis. After transcatheter arterial embolization therapy, she received subsequent chemotherapy with paclitaxel and S-1. Four weeks later, a chest computed tomography examination revealed infiltrative shadows mainly in the right lung field, in addition to enlargement of the lung metastasis in the right middle lung lobe. Bronchofiberscopic examination revealed infiltration of lymphocytes without any malignant cells in the right segment 1 of the lung, which suggested interstitial lung disease...
March 30, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28371214/sarcomatoid-carcinoma-in-the-trachea-a-case-report-and-literature-review
#13
Si-Hyong Jang, Hyun D Cho, Ji-Hye Lee, Hyun J Lee, Soon A Hong, Junhun Cho, Ho S Lee, Mee-Hye Oh
Tracheal sarcomatoid carcinoma is an extremely infrequent neoplasm with unclear pathogenesis and clinical outcomes. To date, only two cases have been described in English literature. We report a case of a 37-year-old patient complaining of hemoptysis, dyspnea, and cough. An intraluminal polypoid mass in the trachea was found and ultimately diagnosed as tracheal sarcomatoid carcinoma in the cervical trachea with both carcinomatous and sarcomatoid morphology. The patient is alive without recurrence after segmental resection of the trachea...
March 30, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28322515/high-dose-radiation-with-chemotherapy-followed-by-salvage-esophagectomy-among-patients-with-locally-advanced-esophageal-squamous-cell-carcinoma
#14
Chawalit Lertbutsayanukul, Chadin Tharavej, Naruemon Klaikeaw, Anussara Prayongrat, Chutinan Lowanitchai, Virote Sriuranpong
BACKGROUND: Locoregional failure is a major problem associated with chemoradiation treatment for squamous cell esophageal carcinoma. The aim of this study was to assess the feasibility, efficacy, and toxicity of preoperative radiation (dose > 50 Gy) with platinum-based chemotherapy followed by esophagectomy in locally advanced squamous cell carcinoma. METHODS: Data of patients with cT2-cT4 or node positive squamous cell carcinoma of the esophagus who received trimodality treatment between February 2006 and June 2015 were reviewed...
March 21, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28322512/clinicopathological-and-prognostic-features-of-surgically-resected-pathological-stage-i-lung-adenocarcinoma-harboring-epidermal-growth-factor-receptor-and-k-ras-mutation
#15
Kaoru Kaseda, Keisuke Asakura, Akio Kazama, Yukihiko Ozawa
BACKGROUND: This study aimed to evaluate mutations of the epidermal growth factor receptor (EGFR) and K-ras genes and their clinicopathological and prognostic features in patients with resected pathological stage I adenocarcinoma. METHODS: We examined 224 patients with surgically resected lung adenocarcinoma and analyzed the prognostic and predictive value of these mutations in 162 patients with pathological stage I adenocarcinoma. RESULTS: Mutations of the EGFR and K-ras genes were detected in 100 (44...
March 21, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28319330/flap-endonuclease-1-rs174538-g-a-polymorphisms-are-associated-with-the-risk-of-esophageal-cancer-in-a-chinese-population
#16
Yonghua Sang, Lin Bo, Haiyong Gu, Wengtao Yang, Yongbing Chen
BACKGROUND: Esophageal cancer has a high mortality rate, particularly in Asia, and there are obvious racial differences in regard to incidence. The purpose of our study was to assess the genetic susceptibility of functional single nucleotide polymorphisms in flap endonuclease-1 (FEN1) in esophageal squamous cell carcinoma ESCC. METHODS: Clinical blood samples of 629 ESCC cases and 686 control samples were collected. The ligation detection reaction method was used to determine FEN 1 rs174538 G>A genotypes...
March 20, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28304139/efficacy-and-safety-of-weekly-intravenous-nanoparticle-albumin-bound-paclitaxel-for-non-small-cell-lung-cancer-patients-who-have-failed-at-least-two-prior-systemic-treatments
#17
Jianchun Duan, Yueqin Hao, Rui Wan, Sifan Yu, Hua Bai, Tongtong An, Jun Zhao, Zhijie Wang, Minglei Zhuo, Jie Wang
BACKGROUND: The study was conducted to evaluate the efficacy and safety of weekly intravenous nanoparticle albumin-bound paclitaxel (NAB-paclitaxel) treatment in patients with advanced non-small-cell lung cancer (NSCLC) who have undergone multi-line therapy, and to investigate the association of secreted protein acidic and rich in cysteine (SPARC) expression status with clinical outcome. METHODS: Sixty-four patients who received NAB-paclitaxel treatment (130 mg/m(2) on days 1 and 8 of a 21 day cycle) as third line or further systemic treatment from 1 May 2011 to 30 June 2014 were included in this retrospective analysis...
March 17, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28294549/clinical-and-computed-tomography-findings-in-chinese-lung-cancer-patients-with-hiv-infection-a-multi-center-study
#18
Zenghui Cheng, Fei Shan, Jinxin Liu, Yuxin Shi, Zhiyong Zhang, Guowei Wu
BACKGROUND: The study was conducted to investigate clinical and computed tomography (CT) features in Chinese lung cancer patients with human immunodeficiency virus (HIV). METHODS: Forty consecutive lung cancer patients with HIV were included. Clinical data were collected, and CT features were reviewed and measured. The factors associated with stages of cancer and the CT features with opportunistic pulmonary infections (OPIs) were also analyzed. RESULTS: Thirty-four of the patients were men (85%), and the mean age was 57...
March 15, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28296260/female-breast-cancer-incidence-and-mortality-in-china-2013
#19
Ting-Ting Zuo, Rong-Shou Zheng, Hong-Mei Zeng, Si-Wei Zhang, Wan-Qing Chen
BACKGROUND: Breast cancer is the most common cancer among women. Population-based cancer registration data from the National Central Cancer Registry were used to analyze and evaluate the incidence and mortality rates in China in 2013, providing scientific information for cancer prevention and control. METHODS: Pooled data were stratified by area (urban/rural), gender, and age group. National new cases and deaths were estimated using age-specific rates and the corresponding population in 2013...
March 13, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28296173/snail-acetylation-by-histone-acetyltransferase-p300-in-lung-cancer
#20
Rui Chang, Yinjie Zhang, Peng Zhang, Qinghua Zhou
BACKGROUND: Epithelial to mesenchymal transition (EMT) is a complex and dynamic molecular event in lung cancer metastasis that has not yet been thoroughly investigated. EMT transcriptional factors, such as Snail, play a central role in regulation of the EMT process. In this study, we sought to identify an association between p300 and Snail in lung cancer, as well as the engagement of p300 in Snail acetylation. METHODS: We transfected p300 small interfering RNA into lung cancer cells to detect Snail and E-cadherin expression levels by real time-PCR...
March 13, 2017: Thoracic Cancer
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