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Thoracic Cancer

Michael Simon, Tzippy Shochat, Nir Peled, Alona Zer, Mordechai R Kramer, Orit Eldan, Milton Saute, Elizabeth R Dudnik, Aaron M Allen
BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare disease and management of localized disease is controversial. Radiotherapy has been shown to be useful after extrapleural pneumonectomy (EPP), as well as with less aggressive surgery. As no reports of the treatment of this disease have ever been published from Israel, we report our experience with MPM and intensity-modulated radiotherapy (IMRT). METHODS: The complete medical records of patients treated for MPM at the Rabin Medical Center from 1 August 2007 to 31 March 2016 were reviewed...
September 21, 2018: Thoracic Cancer
Yuichiro Azuma, Hideya Ono, Kazumi Kawabe, Ryuta Yanagimoto, Tadatoshi Suruda, Yoshiaki Minakata
No abstract text is available yet for this article.
September 19, 2018: Thoracic Cancer
Hongwu Wang, Mingyao Ke, Wen Li, Zikai Wang, Hui Li, Minghua Cong, Yiming Zeng, Liangan Chen, Guoxiang Lai, Baosong Xie, Nan Zhang, Wangping Li, Hongmei Zhou, Xiaoping Wang, Dianjie Lin, Yunzhi Zhou, Huaping Zhang, Dongmei Li, Xiaolian Song, Juan Wang, Shiman Wu, Meimei Tao, Zhengbu Sha, Qiang Tan, Xinwei Han, Lingfei Luo, Hongming Ma, Zhiqiang Wang
Acquired respiratory-digestive tract fistulas occur with abnormal communication between the airways and digestive tract, causing the interflow of gas and liquid. Despite advances in surgical methods and the development of multimodal therapy in recent years, patients with acquired respiratory-digestive tract fistulas continue to exhibit unfavorable clinical outcomes. Therefore, in order to guide clinical practice in China, the Respiratory and Cancer Intervention Alliance of the Beijing Health Promotion Association organized a group of experienced experts in the field to develop this consensus document...
September 17, 2018: Thoracic Cancer
Zhi Guo, Hong Shi, Wentao Li, Dongmei Lin, Changli Wang, Chen Liu, Min Yuan, Xia Wu, Bin Xiong, Xinhong He, Feng Duan, Jianjun Han, Xueling Yang, Haipeng Yu, Tongguo Si, Linfeng Xu, Wenge Xing, Huang Jinhua, Yingjuan Wang, Hui Xie, Li Cui, Wei Gao, Dongfeng He, Changfu Liu, Zhou Liu, Chunhua Ma, Jie Pan, Haibo Shao, Qiang Tu, Li Yong, Yan Xu, Zhang Weihao, Zou Qiang, Sen Wang
Biopsy has been used to diagnose thoracic diseases for more than a century. Percutaneous needle biopsy plays a crucial role in the diagnosis, staging, and treatment planning for tumors in the lungs, thoracic wall, hilum, and mediastinum. With the continuous improvement in imaging techniques, the range of clinical applications for percutaneous needle biopsy is also expanding. It has become important to improve Chinese professionals' and technicians' understanding of percutaneous transthoracic needle biopsy (PTNB) in order to standardize operating procedures and to strengthen perioperative management...
September 17, 2018: Thoracic Cancer
Se-Il Go, Hankyu Jeon, Sung Woo Park, Myoung Hee Kang, Hoon-Gu Kim, Gyeong-Won Lee
BACKGROUND: The importance of nutritional status and chronic inflammation has been emphasized in cancer. We investigated the impact of Onodera's prognostic nutritional index (OPNI) on clinical outcomes in small cell lung cancer (SCLC) patients. METHODS: Data from 220 SCLC patients treated with first-line platinum-based chemotherapy from 2006 to 2017 were retrospectively reviewed. The OPNI was calculated as 10 × serum albumin level (g/dL) + 0.005 × absolute lymphocyte count (/mm3 )...
September 13, 2018: Thoracic Cancer
Meiling Huang, Changjiao Yan, Hongliang Wei, Yonggang Lv, Rui Ling
BACKGROUND: The specific clinical features of thyroid cancer patients in northwest China are unclear; therefore, we analyzed the clinicopathological characteristics and prognosis of this population. METHODS: Clinical characteristics including age, gender, blood type, histological type, and BRAFV600E gene mutation; and incidence; risk factors; surgical treatment; and prognosis were recorded. RESULTS: A total of 2490 thyroid cancer patients were included; 98% were diagnosed with papillary thyroid cancer (PTC)...
September 12, 2018: Thoracic Cancer
Yuki Nakamura, Tetsu Kobayashi, Yoichi Nishii, Yuta Suzuki, Haruko Saiki, Kentaro Ito, Fumiaki Watanabe, Kota Nishihama, Taro Yasuma, Corina N D'Alessandro-Gabazza, Koji Katsuta, Hajime Fujimoto, Esteban C Gabazza, Osamu Taguchi, Osamu Hataji
BACKGROUND: Molecular targeted therapy including the use of monoclonal antibodies directed against the immune checkpoints PD-L1 and PD-1 receptor have remarkably improved the therapeutic response and survival of cancer patients. The tumor expression level of PD-L1 can predict the response rate to checkpoint inhibitors. We evaluated whether the time interval between tumor tissue sampling/paraffinization and immunohistochemistry affects the staining level of PD-L1 in non-small cell lung cancer (NSCLC)...
September 12, 2018: Thoracic Cancer
Wei Li, Wei Zhang, Wenjing Deng, Yujie Zhong, Yonghong Zhang, Zhuo Peng, Haijuan Chen, Ruiying Sun, Xuemei Zhang, Shuanying Yang
BACKGROUND: Small cell lung cancer (SCLC) is highly aggressive and is associated with a dismal prognosis. However, there are no clinically recognized biomarkers for early diagnosis. In this study, we used quantitative proteomics to build differential mitochondrial protein profiles that may be used for early diagnosis and investigated the pathogenesis of lung cancer. METHODS: We cultured SCLC cells (NCI-H446) and normal human bronchial epithelial cells (16-HBE); mitochondria were extracted and purified using differential and Percoll density gradient centrifugation...
September 9, 2018: Thoracic Cancer
Jia-Tao Zhang, Yi-Chun Tang, Jun-Tao Lin, Song Dong, Qiang Nie, Ben-Yuan Jiang, Hong-Hong Yan, Zheng-Wei Wen, Yue Wu, Xue-Ning Yang, Yi-Long Wu, Wen-Zhao Zhong
BACKGROUND: Since the conception of enhanced recovery after surgery protocols, tubeless strategies have become popular. Herein, we introduce a previously unreported alternative air-extraction strategy for patients who have undergone thoracoscopic wedge resection and explore its feasibility and safety. METHODS: Between January 2015 and June 2017, 264 consecutive patients underwent thoracoscopic wedge resection with different drainage strategies. Patients were divided according to the postoperative drainage strategies used: routine chest tube drainage (RT group), complete omission of chest tube drainage (OT group), and prophylactic air-extraction catheter insertion procedure (PC group)...
September 6, 2018: Thoracic Cancer
Cheng Ding, Xiaofei Zhou, Chun Xu, Jun Chen, Shen Ju, Tengfei Chen, Zhipan Liang, Zihan Cui, Chang Li, Jun Zhao
BACKGROUND: The aim of this study was to determine a correlation between benign and malignant lung solitary pulmonary nodules (SPN), and analyze the association between circulating tumor cell (CTC) levels and different subtypes of lung adenocarcinoma. METHODS: A total of 200 patients (80 with SPNs and 120 diagnosed with lung cancer) were included in the study. The CTC levels were quantified by identifying the folate receptor on the surface of tumor cells; clinical tumor specific markers were detected by biochemical immunization...
September 4, 2018: Thoracic Cancer
Jianchun Duan, Xidong Liu, Han Chen, Yu Sun, Yiqiang Liu, Hua Bai, Jie Wang
BACKGROUND: Advanced thymic epithelial tumors (TETs) are indolent and poorly responsive to chemotherapy. PD-1/PD-L1 inhibitors have shown remarkable clinical benefit in several cancers; however, many immunomodulatory molecules have been identified that affect the immune response. This study examined the progonostic roles of PD-L1, transforming growth factor-β (TGF-β), and CD8+ tumor-infiltrating lymphocytes (CD8+ TILs) in patients with TETs. METHODS: Retrospective analysis was performed on the data of 20 patients with stage IV thymic carcinoma and 13 with stage III/IV invasive thymoma...
August 31, 2018: Thoracic Cancer
Kun Qian, Yan Wang, Lin Hua, Anyu Chen, Yi Zhang
Surface-enhanced Raman spectroscopy (SERS) is a surface-sensitive technique that enhances Raman scattering by molecules adsorbed on nanostructures. The advantages of using SERS include high detection sensibility and fast analysis, thus it is a potentially promising tool for sensing metabolic cancer molecules in trace amounts. To explore this new method of lung cancer detection, we analyzed saliva samples from 61 lung cancer patients and 66 healthy controls. An SERS system and a nano-modified chip were used in this study...
August 31, 2018: Thoracic Cancer
Jae Jun Jung, Sung Hwan Kim, Dong Hoon Kang, Ki Nyun Kim, Seong Ho Moon, Jun Ho Yang, Joung Hun Byun, Jong Woo Kim, Kyung Nyeo Jeon, Kyungsoo Bae, Ho Cheol Kim, Ju Young Kim, Hyun Oh Park, Jun Young Choi
An 8.0 × 7.0 × 3.0 cm calcified anterior mediastinal mass was found in a 57-year-old man during a regular health checkup. The tumor had invaded the pericardium and phrenic nerve. The Masaoka-Koga classification was stage III. Multiple ring calcifications were present in the gross feature, and osseous metaplasia was observed in the histologic examination. World Health Organization histologic classification of the tumor was type B2. The patient is currently undergoing chemotherapy and radiation therapy to prevent tumor recurrence...
August 31, 2018: Thoracic Cancer
Hyun-Il Gil, Junsu Choe, Byeong-Ho Jeong, Sang-Won Um, Kyeongman Jeon, Joo-Yong Hahn, Hojoong Kim, O Jung Kwon, Yoon Soo Chang, Kyungjong Lee
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) may be necessary for patients with incidental lung cancer during or after coronary intervention. Although EBUS-TBNA is quite safe, the safety in patients who recently received percutaneous coronary intervention (PCI) has not been demonstrated. The aim of this study was to assess the safety of EBUS-TBNA in patients with lung cancer who underwent PCI within one year. METHODS: We retrospectively reviewed the medical records of 24 patients who underwent EBUS-TBNA within one year after PCI between May 2009 and June 2017...
August 29, 2018: Thoracic Cancer
Tommi Järvinen, Ilkka Ilonen, Juha Kauppi, Kirsi Volmonen, Jarmo Salo, Jari Räsänen
BACKGROUND: In esophageal cancer, nutritional challenges are extremely common. Malignant obstruction resulting from esophageal cancer (EC) is often treated by the insertion of expandable stents, but little is known as to the role and evolution of sarcopenia in this patient population. The aim of this article was to determine the effects of body mass parameters on survival of advanced EC patients who received a stent for palliation of malignant obstruction. METHODS: This was a retrospective observational study of 238 EC patients who had a stent inserted for palliation of malignant obstruction between 2005 and 2013...
August 29, 2018: Thoracic Cancer
Yongzheng Wang, Bin Liu, Pikun Cao, Wujie Wang, Wei Wang, Haiyang Chang, Dong Li, Xiao Li, Xiaogang Zhao, Yuliang Li
BACKGROUND: The study was conducted to investigate the effectiveness and cost of computed tomography (CT)-guided percutaneous microwave ablation (MWA) and thoracoscopic lobectomy for stage I non-small cell lung cancer (NSCLC). METHODS: We retrospectively analyzed the data of 46 and 85 patients with stage I NSCLC treated with CT-guided percutaneous MWA or thoracoscopic lobectomy, respectively, at our center from July 2013 to June 2015. Overall survival (OS), disease-free survival (DFS), local control rate, hospital stay, and cost were evaluated...
August 28, 2018: Thoracic Cancer
Maako Ide, Kentaro Tanaka, Shunya Sunami, Tatsuma Asoh, Takashige Maeyama, Nobuko Tsuruta, Yoichi Nakanishi, Isamu Okamoto
The efficacy and safety of immune-checkpoint inhibitors in non-small cell lung cancer patients with idiopathic pulmonary fibrosis (IPF) remain unknown. Herein, we describe the case of a 62-year-old man with multiple pleural tumors and carcinomatous pleurisy. High-resolution computed tomography indicated usual interstitial pneumonia, and a respiratory function test revealed a restrictive disorder and decreased diffusion capacity. He was diagnosed with lung adenocarcinoma and IPF. After failure of initial chemotherapy, he was treated with nivolumab and achieved a complete response without any sign of exacerbation of IPF...
August 28, 2018: Thoracic Cancer
Donglai Chen, Rui Mao, Xiermaimaiti Kadeer, Weiyan Sun, Erjia Zhu, Qiao Peng, Chang Chen
BACKGROUND: Ipsilateral pulmonary reoperation is empirically considered a contraindication of video-assisted thoracic surgery (VATS) because of intrapleural adhesion and the destruction of anatomical structures caused by previous surgery. The purpose of this study was to present our experience of the use of VATS for ipsilateral reoperations. METHODS: The medical records of patients who underwent VATS reoperation or re-thoracotomy between January 2006 and March 2017 were retrospectively reviewed...
August 28, 2018: Thoracic Cancer
Shengyu Zhou, Lijie Zuo, Xiaohui He, Jinping Pi, Jun Jin, Yuankai Shi
BACKGROUND: Recombinant human endostatin (rh-endostatin) plus standard chemotherapy in advanced non-small cell lung cancer (NSCLC) patients has shown improved efficacy; however, it is unclear whether it is effective and safe when added to pemetrexed/cisplatin and used as maintenance therapy. METHODS: We retrospectively evaluated the data of untreated NSCLC patients administered rh-endostatin plus pemetrexed/cisplatin or pemetrexed/cisplatin. The primary endpoint was progression-free survival (PFS)...
August 27, 2018: Thoracic Cancer
Te-Chun Hsia, Ji-An Liang, Chia-Chin Li, Chun-Ru Chien
BACKGROUND: The standard of care for fit locally advanced non-small cell lung cancer (NSCLC) patients is concurrent chemoradiotherapy (CCRT). However, in a subset of patients with lung adenocarcinoma with mutant EGFR (LA-mEGFR), the role of EGFR-tyrosine kinase inhibitors (TKIs) is not clear. We compared CCRT versus TKIs for the treatment of stage IIIb LA-mEGFR in a Taiwanese population. METHODS: We identified patients from the Taiwan Cancer Registry with good performance status at clinical stage IIIb LA-mEGFR, diagnosed from June 2011 to December 2015 and treated with either TKIs or CCRT...
August 27, 2018: Thoracic Cancer
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