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Thoracic Cancer

Yun-Long Zhao, Jing-Bo Li, Ying-Jie Li, Shao-Jun Li, Shao-Hua Zhou, Hui Xia
BACKGROUND: Capn4 and ZEB1 play important roles in the metastasis of several types of cancer. However, the roles and relationship of Capn4 and ZEB1 in esophageal squamous cell carcinoma (ESCC) remain unclear. METHODS: ESCC tumor tissues and corresponding normal esophageal epithelial tissues were obtained from 86 patients undergoing resection surgery at the Department of General Surgery, First Affiliated Hospital of Chinese PLA General Hospital from 2012 to 2017...
November 15, 2018: Thoracic Cancer
Lin Wang, Gaochao Dong, Wenjie Xia, Qixing Mao, Anpeng Wang, Bing Chen, Weidong Ma, Yaqin Wu, Lin Xu, Feng Jiang
BACKGROUND: Developments in high-throughput genomic technologies have led to improved understanding of the molecular underpinnings of esophageal squamous cell carcinoma (ESCC). However, there is currently no model that combines the clinical features and gene expression signatures to predict outcomes. METHODS: We obtained data from the GSE53625 database of Chinese ESCC patients who had undergone surgical treatment. The R packages, Limma and WGCNA, were used to identify and construct a co-expression network of differentially expressed genes, respectively...
November 12, 2018: Thoracic Cancer
Fengwei Tan, Yalong Wang, Shugeng Gao, Qi Xue, Juwei Mu, Yousheng Mao, Yushun Gao, Jun Zhao, Dali Wang, Lina Zhou, Jie He
BACKGROUND: This study explored the clinicopathological features, predictive factors of malignancy, effectiveness of video assisted thoracic surgery (VATS), and prognosis of solitary fibrous tumor of the pleura (SFTP). METHODS: A single-center retrospective study of the data of 82 patients with SFTP who were surgically treated in our department between January 2003 and December 2015 was conducted. RESULTS: A total of 82 SFTPs (70 benign, 12 malignant) were included and all patients underwent complete en bloc resection...
November 10, 2018: Thoracic Cancer
Yang Wang, Jun Nie, Ling Dai, Weiheng Hu, Xiaoling Chen, Jindi Han, Xiangjuan Ma, Guangming Tian, Sen Han, Jieran Long, Ziran Zhang, Jian Fang
BACKGROUND: Thymoma and thymic carcinoma are rare thymic epithelial tumors. We investigated the efficacy of first-line gemcitabine and cisplatin (GP) chemotherapy versus gemcitabine and cisplatin chemotherapy combined with the anti-angiogenic drug endostar (GP + E) in advanced thymoma and thymic carcinoma. METHODS: The records of 45 patients with invasive metastatic thymomas or thymic carcinomas treated with GP as first-line therapy between August 2008 and July 2017 at the Department of Respiratory Medicine, Peking University Cancer Hospital and Institute were retrospectively reviewed...
November 9, 2018: Thoracic Cancer
Shunichiro Matsuoka, Tsutomu Koyama, Tetsu Takeda, Kyoko Yamada, Akira Hyogotani, Kazutoshi Hamanaka, Nodoka Sekiguchi, Tomonobu Koizumi
Herein, we report a case of an angiosarcoma in a mediastinal non-seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy. A 26-year-old man presented with a giant anterior mediastinal mass, which was diagnosed as a non-seminomatous germ cell tumor. The patient was administered three cycles of chemotherapy (bleomycin, etoposide, and cisplatin), but the mass grew despite normalization of tumor markers. Massive bleeding during thoracic surgery resulted in incomplete resection, and the mass was clinically and pathologically diagnosed as growing teratoma syndrome (only mature teratoma)...
November 8, 2018: Thoracic Cancer
Changkang Ke, Kai Zhu, Ying Sun, Yunfeng Ni, Zhipei Zhang, Xiaofei Li
BACKGROUND: Our previous study showed that SUMO1 expression is closely related to progression in non-small cell lung cancer (NSCLC); however, the function of SUMO1 in NSCLC has not yet been well elucidated. METHODS: SUMO1 was enhanced or silenced in two NSCLC cell lines by using either forced SUMO1 expression or short hairpin RNA against SUMO1 lentiviral vectors, respectively. The biological functions of SUMO1 in NSCLC were investigated through colony-formation, cell proliferation, and invasion assays, and cell cycle analysis...
November 4, 2018: Thoracic Cancer
Jihua Wang, Dianshui Sun, Kai Wu, Jie Liu, Miaoqing Zhao, Xiaomei Li, Ying Xu, Baosheng Li
BACKGROUND: A high lymphatic metastasis rate and strong local invasive ability are the key characteristics of esophageal squamous cell carcinoma (ESCC) that affect patient survival, and long non-coding RNAs (lncRNAs) may play a crucial role. We performed genome-wide analysis of lncRNAs to identify novel biomarkers associated with local invasion and lymphatic metastasis in ESCC. METHODS: Six pairs of ESCC tumor and para-tumor tissues were subjected to microarray analysis to identify differentially expressed lncRNAs, and 25 pairs of tissues samples were used to verify the effectiveness of screened lncRNAs using quantitative reverse transcription PCR...
November 3, 2018: Thoracic Cancer
Zhenfeng Sun, Gongzhe Liu, Ning Xu
BACKGROUND: Hypermethylation of the CpG island in the promoter regions of tumor suppressor genes is common in the cancer tissue of non-small cell lung cancer (NSCLC) patients. Epithelial cadherin (E-cadherin) is a classic tumor suppressor gene of the cadherin superfamily and its promoter region is usually hypermethylated in malignant carcinomas. However, whether hypermethylation of the CpG island in the promoter region of E-cadherin increases the risk of lung cancer is unknown. We conducted a meta-analysis of E-cadherin gene promoter methylation status in cancer tissue (CT) and autologous controls (AC)...
November 3, 2018: Thoracic Cancer
Wei-Bing Wu, Yang Xia, Xiang-Long Pan, Jun Wang, Zhi-Cheng He, Jing Xu, Wei Wen, Xin-Feng Xu, Quan Zhu, Liang Chen
BACKGROUND: Extended or combined segmentectomies are usually adapted for intersegmental pulmonary nodules. This study explored precise combined subsegmentectomy (CSS) under the guidance of three-dimensional computed tomography bronchography and angiography (3D-CTBA). METHODS: The definition of a pulmonary intersegmental nodule was based on a minimum distance between the nodule and the involved intersegmental veins in the preoperative 3D-CTBA being less than the size of the nodule...
November 3, 2018: Thoracic Cancer
Yang Jiang, Dan Wang, Hui Ren, Ying Shi, Yufei Gao
BACKGROUND: MiR-145 has been identified as a tumor suppressive microRNA in multiple cancers. In this current investigation, we searched for new direct targets of miR-145 and evaluated their effect on breast cancer development. METHODS: Targetscan was used to predict the target genes of miR-145. The targeting of miR-145 on oncogenic HBXIP was verified by luciferase reporter gene analysis. The effect of miR-145 on the level of messenger RNA and protein of HBXIP was evaluated by quantitative real-time PCR and immunoblotting...
October 31, 2018: Thoracic Cancer
Yuequan Shi, Mengzhao Wang
HER2 mutations are a rare group of driving genes that respond to HER2 targeted therapy, particularly afatinib. No more than 20 such cases have been reported, but afatinib was used after first-line chemotherapy. We present the case of a never-smoking female patient diagnosed with stage IV lung adenocarcinoma harboring a Her2 exon 20 inserted mutation who achieved a durable response (12 months) to first-line afatinib treatment. We review the literature concerning afatinib therapy in this rare cohort of mutated lung cancer patients...
October 31, 2018: Thoracic Cancer
Naoya Ishibashi, Haruna Nishimaki, Toshiya Maebayashi, Masaharu Hata, Keita Adachi, Kenichi Sakurai, Shinobu Masuda, Masahiro Okada
BACKGROUND: The Ki-67 labeling index (LI) is a well-known prognostic factor for primary breast cancer, but its clinical significance for metachronous axillary lymph node (ALN) recurrence has not been well documented. METHODS: Ki-67 expression in primary tumors (PTs) and ALN metastases (ALNMs) was evaluated in 21 patients and quantified to investigate the relationship between Ki-67 LIs in PTs and metachronous ALNMs. RESULTS: The median Ki-67 LIs in the PTs and ALNMs were 25...
October 29, 2018: Thoracic Cancer
Di Zhang, Chufeng Zhang, Jiaqi Huang, Yan Guan, Qisen Guo
BACKGROUND: This study was designed to assess the clinical efficacy and toxicity of apatinib (YN968D1) as third or subsequent-line treatment for stage III/IV non-small cell lung cancer (NSCLC). METHODS: A total of 100 patients with advanced NSCLC who were treated with apatinib at a daily dose of 250/425/500 mg at Shandong Cancer Hospital from January 2016 to June 2018 were enrolled in our study. The objective response, disease control, and median progression-free survival rates were reviewed and evaluated...
October 19, 2018: Thoracic Cancer
Kentaro Miura, Kazutoshi Hamanaka, Shunichiro Matsuoka, Tetsu Takeda, Hiroyuki Agatsuma, Akira Hyogotani, Ken-Ichi Ito, Fumihiro Nishimaki, Tomonobu Koizumi, Takeshi Uehara
BACKGROUND: Liposarcoma has been subclassified histologically into well-differentiated, myxoid, pleomorphic, and dedifferentiated types. The dedifferentiated type generally shows poorer prognosis than the well-differentiated type. Because of its rarity, the clinicopathological features and clinical outcomes of primary mediastinal dedifferentiated liposarcoma remain unclear. METHODS: Five patients with primary mediastinal dedifferentiated liposarcoma were treated at Shinshu University Hospital between January 2012 and August 2017...
October 17, 2018: Thoracic Cancer
Masaki Kanazu, Ryuya Edahiro, Hiroyuki Krebe, Kohei Nishida, Mikako Ishijima, Takeshi Uenami, Yuki Akazawa, Yukihiro Yano, Toshihiko Yamaguchi, Masahide Mori
Nivolumab is an anti-PD-1 blocking monoclonal antibody approved for the treatment of non-small cell lung cancer (NSCLC). However, some patients on immunotherapy may experience rapid progression and worsening clinical status, known as hyperprogressive disease. We retrospectively reviewed the clinical records of patients with NSCLC administered nivolumab therapy at Toneyama National Hospital, Japan, from January 2016 to January 2018. Of the 87 patients administered nivolumab therapy, five experienced rapid progression during one cycle of nivolumab therapy...
October 17, 2018: Thoracic Cancer
Shuangjiang Li, Yan Wang, Kun Zhou, Shan Cheng, Yanming Wu, Guowei Che
BACKGROUND: The study was conducted to demonstrate the predictive value of body surface area (BSA) for chylothorax complicating video-assisted thoracoscopic surgery (VATS) lobectomy for non-small cell lung cancer (NSCLC). METHODS: Large-scale retrospective analysis was conducted on the data of 1379 patients who underwent VATS lobectomy between January 2014 and October 2017 at our institution. Receiver operating characteristic analysis was conducted to determine a threshold BSA value for the prediction of chylothorax...
October 16, 2018: Thoracic Cancer
Puyuan Xing, Yuxin Mu, Yan Wang, Xuezhi Hao, Yixiang Zhu, Xingsheng Hu, Hongyu Wang, Peng Liu, Lin Lin, Zhijie Wang, Junling Li
BACKGROUND: Bevacizumab (Bev) plus platinum-based chemotherapy is a standard first-line treatment option for advanced non-squamous non-small cell lung cancer (NS-NSCLC). We evaluated the efficacy and safety of continuing Bev in Chinese patients with advanced NS-NSCLC progression after first-line treatment containing Bev in a real-world setting. METHODS: The data of 118 patients with advanced NS-NSCLC who received Bev between July 2009 and July 2017 were retrospectively collected...
October 16, 2018: Thoracic Cancer
Miao Chen, Songbo Xie
Similar to bacteria, yeast, and other organisms that have evolved pathways to respond to environmental stresses, cancer cells develop mechanisms that increase genetic diversity to facilitate adaptation to a variety of stressful conditions, including hypoxia, nutrient deprivation, exposure to DNA-damaging agents, and immune responses. To survive, cancer cells trigger mechanisms that drive genomic instability and mutation, alter gene expression programs, and reprogram the metabolic pathways to evade growth inhibition signaling and immune surveillance...
October 12, 2018: Thoracic Cancer
Guang-Wen Xu, Han-Ran Wu, Ran Xiong, Cai-Wei Li, Chang-Qing Liu, Mei-Qing Xu, Ming-Ran Xie
BACKGROUND: This study investigated the relationship between the neutrophil-to-lymphocyte ratio (NLR) and clinicopathological features and prognosis in patients with postoperative esophageal squamous cell carcinoma (ESCC). METHODS: The preoperative NLR was evaluated in 419 patients who underwent esophagectomy for ESCC. A receiver operating characteristic (ROC) curve was plotted to verify the accuracy of the NLR for predicting survival. Correlation between the NLR and clinicopathological characteristics was analyzed using the χ2 test...
October 12, 2018: Thoracic Cancer
Takuya Matsui, Tetsuya Mizuno, Hiroaki Kuroda, Noriaki Sakakura, Takaaki Arimura, Yasushi Yatabe, Yukinori Sakao
Spontaneous regression (SR) of cancer implies the partial or complete disappearance of malignant disease without or with adequate medical treatment. Typically, SR of cancer is a sporadic event, especially in non-small cell lung cancer (NSCLC). Although the underlying mechanism of SR remains unknown, stimulation of an immunological response has been proposed. Herein, we report the case of a 56-year-old woman exhibiting SR of NSCLC with a mediastinal disease. Despite regression of the primary site after a lung biopsy, simultaneous progression of mediastinal lymph node metastasis occurred...
October 11, 2018: Thoracic Cancer
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