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Thoracic Cancer

Kazuaki Okamura, Yuichi Fukuda, Hiroshi Soda, Daiki Ogawara, Keisuke Iwasaki, Shinichiro Fuchi, Takayuki Suyama, Masataka Yoshida, Tatsuhiko Harada, Minoru Fukuda, Hiroshi Mukae
Pulmonary pleomorphic carcinoma has been shown to respond remarkably to PD-1 inhibitors; however, the biomarkers for this therapy have not been fully proven. We report a case of pulmonary pleomorphic carcinoma with overexpressed PD-L1, in which a complete response to nivolumab was sustained for >14 months. Immunohistochemical analysis revealed few PD-1(+) immune cells and regulatory T cells in the tumor, in addition to predominant infiltration of CD8(+) cells and macrophages. Our findings suggest that the presence of a small number of PD-1(+) immune cells and regulatory T cells should be investigated as candidate therapeutic biomarkers...
November 13, 2017: Thoracic Cancer
Shanshan Fan, Yin Guan, Guanfei Zhao, Guangyu An
BACKGROUND: Elevated plasma fibrinogen (Fbg) levels contribute to tumor progression and metastasis; however, limited research on Fbg in small cell lung cancer (SCLC) has been conducted. This study evaluated the prognostic value of Fbg levels in patients with SCLC. METHODS: Data on plasma Fbg level, clinical features, and overall survival were retrospectively collected. Kaplan-Meier estimates and log-rank tests were used to analyze the relationship between Fbg level and survival...
November 13, 2017: Thoracic Cancer
Shijie Zhang, Weiming Huang, Xiangzheng Liu, Jian Li
BACKGROUND: This study explored how to improve the surgical technique to reduce or avoid anastomotic leakage. METHODS: From January 2012 to December 2016, 101 consecutive patients with cancer of the esophagus or gastroesophageal junction underwent stapled gastroesophageal anastomosis. The procedure included creating a tube-type stomach, fixing an inserted anvil, inspecting mucosa-to-mucosa alignment in the lumen under direct vision after firing the stapler, and, if found, manually repairing a rupture of the mucous membrane of the anastomosis...
November 11, 2017: Thoracic Cancer
Cuicui Liu, Jiaqiang Xing, Yujun Gao
BACKGROUND: Lung cancer is one of the most frequently diagnosed malignancies in the world, thus developing novel anticancer reagents for lung cancer treatment is critical. METHODS: We performed cell counting kit-8 and cell colony formation assays to investigate the role of UNBS5162 in the proliferation of A549 cells. Invasion and migration assays were applied to study the inhibitory effect of UNBS5162 on non-small cell lung cancer cells. To detect the effect of UNBS5162 on A549 cell apoptosis, Annexin-V fluorescein isothiocyanate and propidium iodide staining methods were used...
November 11, 2017: Thoracic Cancer
Jikai Zhao, Jinchen Shao, Ruiying Zhao, Rong Li, Keke Yu, Lei Zhu, Jie Zhang
BACKGROUND: Although patients with EGFR mutated lung adenocarcinoma benefit greatly from tyrosine kinase inhibitors (TKIs), they inevitably develop acquired resistance after an average of 10-14 months of continuous treatment. METHODS: We retrospectively analyzed the clinical and histopathological data of eight patients with primary lung adenocarcinoma harboring EGFR mutations that transformed into high-grade neuroendocrine carcinoma after TKI therapy. Morphology scanning for neuroendocrine differentiation and immunohistochemistry for neuroendocrine markers CD56, chromogranin, and synaptophysin were performed on primary adenocarcinoma tissues and repeated biopsies...
November 9, 2017: Thoracic Cancer
Yinan Guo, Mei Jiang, Xiaoting Zhao, Meng Gu, Ziyu Wang, Shaofa Xu, Wentao Yue
BACKGROUND: Cyclophilin A (CypA) is associated with metastasis in diverse cancers; however, its role in lung cancer metastasis and the underlying mechanisms remain poorly understood. Our study investigated the effect of CypA on non-small cell lung cancer (NSCLC) metastasis in vitro and in vivo to determine its mechanisms. METHODS: In this study, A549 and H1299 cell lines with downregulated and overexpressed CypA, respectively, were constructed by lentivirus transfection of NSCLC cells...
November 7, 2017: Thoracic Cancer
Hyo-Jae Lee, Hyun Ju Seon, Yoo-Duk Choi
A mediastinal germ cell tumor with a sarcomatous component is extremely rare and is accompanied by a poor prognosis. Clinical and radiologic diagnosis is very difficult. Herein, we report a rare case of anterior mediastinal malignant teratoma containing a growing liposarcomatous component and detail the diagnostic process. The case was diagnosed by repeated transthoracic needle biopsy and correlated with changes in follow-up chest computed tomography and serum tumor markers. We also provide a review of the literature...
November 6, 2017: Thoracic Cancer
Shaoqing Shi, Wei Luo, Rui Zhang, Chu Wang, Yuanyuan Zheng, Yunhua Song, Rongchun Wang, Liyan Zhang, Lihua Zhang, Weimin Li, Zhuang Luo
BACKGROUND: CRTC2 is highly expressed in lung cancer and contributes to lung cancer pathogenesis; however, whether CRTC2 promotes lung cancer metastasis remains unknown. In the present study, we investigated the role of CRTC2 in lung cancer metastasis in vitro. METHODS: CRTC2 stable knockdown of lung cancer cell A549 was generated with small hairpin RNA and confirmed by quantitative reverse transcription-PCR and Western blot. Wound healing and invasion transwell assays were performed to explore migration and invasion activity, and Western blot was conducted to detect the expression of related proteins...
November 3, 2017: Thoracic Cancer
Michihito Toda, Takuma Tsukioka, Nobuhiro Izumi, Hiroaki Komatsu, Satoshi Okada, Kantaro Hara, Hikaru Miyamoto, Ryuichi Ito, Toshihiko Shibata, Noritoshi Nishiyama
BACKGROUND: Markers of preoperative tumor immunity, such as platelet-to-lymphocyte ratio (PLR), have been reported to be prognostic factors for patients with various cancers. However, the relationship between PLR and the prognosis of non-small cell lung cancer (NSCLC) patients treated with surgery and adjuvant chemotherapy as a multidisciplinary treatment is unknown. METHODS: We enrolled 327 NSCLC patients treated surgically with or without adjuvant chemotherapy (78 and 249 patients, respectively) at our hospital from 2008 to 2012...
November 3, 2017: Thoracic Cancer
Hiroki Sakai, Hisashi Saji, Hiroyuki Kimura, Masataka Tsuda, Yoichi Wakiyama, Tomoyuki Miyazawa, Hideki Marushima, Koji Kojima, Masahiro Hoshikawa, Masayuki Takagi, Haruhiko Nakamura
Routine clinical and pathological evaluations to determine the relationship between different lesions are often not completely conclusive. Interestingly, detailed genetic analysis of tumor samples may provide important additional information and identify second primary lung cancers. In the present study, we report cases of two synchronous lung adenocarcinomas composed of two distinct pathological subtypes with different EGFR gene mutations: a homozygous deletion in exon 19 of the papillary adenocarcinoma subtype and a point mutation of L858R in exon 21 of the tubular adenocarcinoma...
November 1, 2017: Thoracic Cancer
Kaijiong Zhang, Zhenglian Luo, Yi Zhang, Yuzhi Wang, Meng Cui, Lian Liu, Li Zhang, Jinbo Liu
BACKGROUND: Previous studies have indicated that large intergenic non-coding RNA regulator of reprogramming (lincRNA-ROR) plays an important role in regulating tumor carcinogenesis and metastasis; however, whether circulating lincRNA-ROR could function as a potential biomarker for breast cancer (BC) diagnosis and monitoring is unknown. This study was conducted to investigate circulating lincRNA-ROR in plasma as a potential biomarker for BC diagnosis and monitoring. METHODS: We performed reverse transcription-quantitative-PCR to examine lincRNA-ROR expression levels in cell lines, 24 pairs of BC tissue samples, and 94 plasma samples from BC patients...
November 1, 2017: Thoracic Cancer
Haitao Huang, Haitao Ma, Shaomu Chen
BACKGROUND: This study investigated the clinical efficiency of enhanced recovery after surgery (ERAS) using uniportal video-assisted thoracoscopic surgery for lung cancer. METHODS: The clinical data of 83 patients with early-stage non-small cell lung cancer (NSCLC) at the First Affiliated Hospital of Soochow University from January 2016 to February 2017 were retrospectively analyzed. ERAS was applied to 38 patients (ERAS group), while 45 patients received conventional surgical treatment (control group)...
October 31, 2017: Thoracic Cancer
Aizemaiti Rusidanmu, Sha Huang, Xiayi Lv
BACKGROUND: Thymic complete resection is considered the standard treatment for all thymic tumors; however, the ideal resection for non-myasthenic early stage thymic tumors has not yet been determined. We conducted a retrospective study to examine this unique scenario. METHODS: We retrospectively analyzed the data of 118 early stage thymoma patients who underwent thymectomy (TM) or thymomectomy (TMM) with curative intent between January 2003 and December 2013 at our institution...
October 31, 2017: Thoracic Cancer
Xufeng Guo, Bo Ye, Yu Yang, Yifeng Sun, Rong Hua, Xiaobing Zhang, Teng Mao, Zhigang Li
BACKGROUND: Minimally invasive esophagectomy (MIE) is increasingly performed worldwide. Unplanned events during thoracoscopy or laparoscopy can jeopardize the procedure, sometimes necessitating conversion to open surgery. The aim of this study was to evaluate the impact of unplanned events on early postoperative outcomes after MIE. METHOD: A consecutive group of 303 patients who underwent MIE between January 2011 and December 2015 were reviewed. The patients were allocated to two groups comprising those with (G-UPE, 85 patients) and without unplanned events (G-Regular, 218 patients)...
October 30, 2017: Thoracic Cancer
Ching-Kai Lin, Chao-Lun Lai, Lih-Yu Chang, Yueh-Feng Wen, Chao-Chi Ho
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is now the standard for mediastinal lymph node staging of lung cancer. Training and maintenance of technical skills is very important in order to apply new techniques in clinical use. METHODS: A retrospective chart review was performed of patients who underwent EBUS-TBNA from November 2009 to December 2015. We assessed the learning curve, accuracy (%), and whether this procedure shortened the duration of lung cancer staging...
October 30, 2017: Thoracic Cancer
Hongjun Gao, Wenjing Liu, Shaoxing Yang, Wen Zhang, Xiaoyan Li, Haifeng Qin, Weixia Wang, Changyun Zhao
BACKGROUND: This study was conducted to evaluate the clinical utility of the oHSV1-hTERT-GFP circulating tumor cell (CTC) detection method in the peripheral blood of patients with lung cancer by comparing its sensitivity to the CellSearch CTC detection method. METHODS: The oHSV1-hTERT-GFP and CellSearch CTC detection methods were compared using peripheral blood samples of patients pathologically diagnosed with lung cancer. RESULTS: A total of 240 patients with lung cancer were recruited, including 89 patients who were newly diagnosed and 151 patients who had previously received treatment...
October 25, 2017: Thoracic Cancer
Kazutaka Kakinuma, Hazime Tsuruoka, Kei Morikawa, Naoki Furuya, Takeo Inoue, Teruomi Miyazawa, Masamichi Mineshita
BACKGROUND: Recent studies have revealed a reduction in the skeletal muscle area in patients with advanced non-small cell lung cancer (NSCLC) after chemotherapy. EGFR and ALK tyrosine kinase inhibitor (TKI)-based therapies are less cytotoxic than chemotherapy, but differences in skeletal muscle mass between patients receiving EGFR and ALK TKI therapies and patients receiving cytotoxic chemotherapy have not yet been reported. METHODS: Data of pathologically proven NSCLC patients were reviewed, and chest computed tomography and/or positron emission tomography-computed tomography images obtained from January 2012 to December 2014 were selected...
October 25, 2017: Thoracic Cancer
Daiki Ogawara, Hiroshi Soda, Keisuke Iwasaki, Takayuki Suyama, Hirokazu Taniguchi, Yuichi Fukuda, Hiroshi Mukae
Promising outcomes of salvage chemotherapy after nivolumab therapy have been reported; however, little is known about the detailed clinical and immunologic features in lung cancer patients in whom nivolumab is unsuccessful. We report two cases of nivolumab-refractory lung cancer, in which chemotherapy resulted in rapid regression of the lung cancer. Upon initial diagnosis, the biopsy specimens showed PD-ligand 1 (PD-L1)-expressing cancer cells, accompanied by tumor-infiltrating lymphocytes with a favorable CD8/CD4 ratio...
October 24, 2017: Thoracic Cancer
Daiki Ogawara, Hiroshi Soda, Takayuki Suyama, Masataka Yoshida, Tatsuhiko Harada, Yuichi Fukuda, Hiroshi Mukae
The circulating tumor DNA (ctDNA) assay has recently been approved for the selection of EGFR-tyrosine kinase inhibitors as first-line treatment in lung cancer. However, it remains to be determined whether this assay can detect all complex EGFR mutations within a single tumor. We report a case of an elderly woman with stage IV lung adenocarcinoma, in which EGFR mutation assays detected L858R and pretreatment T790M from a tissue biopsy. In contrast, the circulating tumor DNA assay detected L858R, but not pretreatment T790M in the plasma, regardless of the fact that similar amounts of each mutation were present in the biopsy specimen...
October 24, 2017: Thoracic Cancer
Jun Wang, XinFeng Xu, Wei Wen, WeiBing Wu, Quan Zhu, Liang Chen
This paper analyzed the results of a modified and simpler technique for distinguishing the intersegmental border during lung segmentectomy surgery. From January 2013 to December 2015, 539 patients with screening-detected lung nodules <2 cm in maximum diameter underwent anatomic segmentectomy. With the guidance of preoperative three-dimensional computed tomography bronchography and angiography, the bronchus, artery, and intrasegmental vein of the targeted segment could be precisely dissected under unilateral differential ventilation, and then intersegmental demarcation was confirmed by the modified inflation-deflation method...
October 23, 2017: Thoracic Cancer
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