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Thoracic Cancer

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https://www.readbyqxmd.com/read/28805352/vagus-nerve-schwannoma-in-the-right-upper-mediastinum
#1
WeiPeng Zhu, DongHong Chen
A 35-year-old woman was admitted to our hospital with an abnormal shadow on her chest roentgenogram. Computed tomography showed that a tumor was located in the right upper mediastinum. Resection of the tumor by video-assisted thoracoscopic surgery was performed. Operative findings determined that the tumor originated from the right vagus nerve and was diagnosed as schwannoma by pathological examination.
August 14, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28786540/concurrent-epidermal-growth-factor-receptor-t790m-secondary-mutation-and-epithelial-mesenchymal-transition-in-a-lung-adenocarcinoma-patient-with-egfr-tki-drug-resistance
#2
Song Xu, Xia Liu, Renwang Liu, Tao Shi, Xiongfei Li, Diansheng Zhong, Yan Wang, Gang Chen, Jun Chen
Almost all epidermal growth factor receptor (EGFR)-mutant lung cancers develop resistance to EGFR-tyrosine kinase inhibitors. Several mechanisms for this acquired resistance have been identified, including development of an EGFR T790M mutation, MET amplification, hepatocyte growth factor overexpression, loss of phosphatase and tensin homolog expression, epithelial-mesenchymal transition, and transformation to small cell lung cancer. Herein, we report a case of a lung cancer patient with EGFR exon 19 deletion who was resistant to EGFR-tyrosine kinase inhibitor treatment during disease progression...
August 8, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28777494/clinico-radiological-features-and-next-generation-sequencing-of-pulmonary-epithelioid-hemangioendothelioma-a-case-report-and-review-of-literature
#3
Xiaoyong Mao, Zibin Liang, Fidelis Chibhabha, Wei Ou, Ning Li, Pengfei Xu, Siyu Wang
Epithelioid hemangioendothelioma is a very rare, vascular, low-grade malignant tumor found in the lungs, liver, bone, and other soft tissues. Most patients with pulmonary epithelioid hemangioendothelioma (PEH) are asymptomatic but usually present with multiple bilateral nodular lesions in the lungs. Currently, surgical lung biopsy, histology, and immunohistochemical methods are essential for diagnosis. However, there is no standard therapy for the treatment for PEH. Our paper describes the clinico-radiologic features and genomics of PEH based on next-generation sequencing (NGS) in a 43-year-old male we encountered...
August 4, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28771997/epac1-pde4-and-pkc-protein-expression-and-their-correlation-with-akap95-and-cx43-in-esophagus-cancer-tissues
#4
Zhiyu Guan, Winxin Zhuang, Hui Lei, Dai Wang, Youliang Yao, Dongbei Guo, Qian Sun, Yun Chen, Xiaoyi Chen, Hongyan Lin, Bogang Teng, Yongxing Zhang
BACKGROUND: This study examined the expression of exchange protein directly activated by cAMP1 (Epac1), PDE4, and PKC in esophageal cancer tissues, and analyzed the association of each protein with the pathological parameters of the samples. METHODS: Epac1, PDE4, and PKC protein expression was evaluated by PV-9000 two-step immunohistochemical techniques in 51 esophageal cancer specimens and 10 para-carcinoma tissues. RESULTS: The positive expression rates of Epac1 and PKC in esophageal cancer tissues (62...
August 3, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28771961/phase-i-study-of-pemetrexed-and-concurrent-radiotherapy-for-previously-untreated-elderly-patients-with-locally-advanced-non-squamous-non-small-cell-lung-cancer
#5
Shinnosuke Takemoto, Yoichi Nakamura, Minoru Fukuda, Hiroaki Senju, Hiroshi Gyotoku, Hirokazu Taniguchi, Midori Shimada, Takaya Ikeda, Hiroyuki Yamaguchi, Katsumi Nakatomi, Nobuyuki Hayashi, Hiroshi Soda, Hiroshi Mukae
BACKGROUND: Chemoradiotherapy is the standard treatment for locally advanced non-small cell lung cancer (NSCLC); however, it is disputed whether this treatment is suitable for patients aged ≥75. This study was conducted to determine the maximum tolerated dose (MTD) of pemetrexed for use in concurrent radiotherapy for elderly patients with locally advanced non-squamous NSCLC. METHODS: The eligibility criteria were as follows: aged ≥75 with inoperable stage IIIA or IIIB non-squamous NSCLC, no history of chemotherapy or radiotherapy, a performance status of 0 or 1, and adequate organ function...
August 3, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28766861/overexpression-of-nrf2-is-correlated-with-prognoses-of-patients-with-malignancies-a-meta-analysis
#6
Yangyang Guo, Luyan Shen
BACKGROUND: Previous published research has demonstrated that NRF2 expression is a poor prognostic factor for many malignancies. However, because of the small sample enrolled in a single study, it is difficult to draw valuable conclusions. Therefore, we hypothesized that NRF2 overexpression in cancer tissues may be associated with the prognoses of patients with solid malignancies, and conducted a systemic review and meta-analysis. METHODS: A comprehensive search of PubMed, Web of Science, Science Direct, Embase, and Ovid databases for relevant studies regarding the role of NRF2 expression in solid malignancies was conducted...
August 2, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28759156/exclusive-right-thoracic-approach-for-esophagus-surgery
#7
Chuan Li, Nan Ge, Yi Shen, Wenjie Jiao
An exclusive right thoracic approach for esophagus surgery is rarely used, with few reports of its use in China. We retrospectively reviewed the data of 21 esophageal cancer patients from January 2010 to January 2015. Their age ranged from 74-83 years (average 76.6). All of the patients had lower pulmonary function. After multidisciplinary team discussion, sufficient preoperative preparation, and assessment of cardiopulmonary reserve, an exclusive right thoracic approach for esophageal cancer resection was performed...
July 31, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28759148/efficacy-of-prednisone-for-prevention-of-esophageal-stricture-after-endoscopic-submucosal-dissection-for-superficial-esophageal-squamous-cell-carcinoma
#8
Gaosu Zhou, Fangfang Yuan, Jizhen Cai, Xiaowei Tang, Wei Gong, Lei Su, Yali Zhang
BACKGROUND: Our objective was to investigate the efficacy and safety of oral prednisone for the prevention of esophageal stricture formation after endoscopic submucosal dissection (ESD) in an optimal administration program. METHODS: Patients who underwent circumferential or semi-circumferential (more than three quarters but not a complete circular) ESD for esophageal squamous cell carcinoma were eligible for this study. Oral prednisolone was administered to the study group at a dose of 30 mg/day on the third day post-ESD, and then tapered gradually (30, 25, 20, 15, 10, and 5 mg for 14 days)...
July 31, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28755423/epac1-pde4-and-pkc-protein-expression-and-their-association-with-akap95-cx43-and-cyclind2-e1-in-breast-cancer-tissues
#9
Ping Huang, Qian Sun, Wenxin Zhuang, Kuan Peng, Dai Wang, Youliang Yao, Dongbei Guo, Lu Zhang, Chuhan Shen, Mengyun Sun, Chaoying Tang, Bogang Teng, Yongxing Zhang
BACKGROUND: This study was conducted to investigate the exchange protein directly activated by cAMP (Epac1), PDE4, and PKC expression in breast cancer tissues, and the correlation between these proteins and AKAP95, Cx43, cyclin D2, and cyclin E1. METHODS: PV-9000 two-step immunohistochemistry was used to analyze protein expression. RESULTS: The positive rate of Epac1 protein expression in breast cancer tissues (58%) was higher than in para-carcinoma tissues (10%) (P < 0...
July 29, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28755392/high-expression-of-long-non-coding-hox-antisense-transcript-rna-and-its-clinical-significance-in-cancer-tissues-a-meta-analysis
#10
Lei Wang, Yandong Zhao, Yi Qin, Yunpeng Xuan, Tong Qiu, Bo Fu, Xiaoyang Ren, Wenjie Jiao
BACKGROUND: HOX antisense transcript RNA (HOTAIR) is a 2148 nt long, intergenic, non-coding RNA molecule, which is reported to be highly expressed in many types of cancers. This meta-analysis summarizes its expression in cancer. METHODS: We searched all eligible papers on the prognostic impact of HOTAIR in cancer from inception to 30 September 2015 in PubMed, CBMdisc, and the CNKI database. Only full texts were included. Revman 5.3 was used for meta-analysis. RESULTS: A total of 11 studies of 1010 cases were included in the meta-analysis...
July 29, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28752530/hmga2-regulates-lung-cancer-proliferation-and-metastasis
#11
Xiaotian Gao, Ming Dai, Qinglan Li, Zhigang Wang, Yonglin Lu, Zeqing Song
BACKGROUND: This study aimed to explore the effects of HMGA2 on cell proliferation and metastases in lung cancer and its underlying mechanism. METHODS: HMGA2 expression in lung cancer tissues and its association with overall survival were analyzed based on data from a public database. The roles of HMGA2 were validated via loss-of-function and gain-of-function experiments in vitro. HMGA2 regulation by microRNA-195 (miR-195) was validated by real time-PCR, Western blotting, and luciferase reporter assays...
July 28, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28749044/video-assisted-thoracoscopic-lobectomy-after-percutaneous-coronary-intervention-in-lung-cancer-patients-with-concomitant-coronary-heart-disease
#12
Xin Li, YiLi Fu, JinBai Miao, Hui Li, Bin Hu
BACKGROUND: In recent years, based on clinical observations, the number of lung cancer patients with concomitant coronary heart disease (CHD) has gradually increased. However, because of the requirement of long-term anticoagulant therapy after percutaneous coronary intervention (PCI), some of these patients lose the opportunity for surgical treatment, resulting in tumor progression. The objective of this study was to determine the appropriate timing of video-assisted thoracic surgery (VATS) lobectomy after PCI without increasing perioperative cardiovascular risk...
July 27, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28745824/gemcitabine-combined-with-cisplatin-as-adjuvant-chemotherapy-for-non-small-cell-lung-cancer-a-retrospective-analysis
#13
Di Ma, Jing Wang, Xuezhi Hao, Yan Wang, Xingsheng Hu, Puyuan Xing, Junling Li
BACKGROUND: This study was conducted to evaluate the value of gemcitabine combined with cisplatin as adjuvant chemotherapy for radical resection of non-small cell lung cancer. METHODS: Data of 100 patients who had undergone radical resection of non-small cell lung cancer and were treated with cisplatin/gemcitabine as adjuvant chemotherapy between June 2007 and December 2010 at the Chinese Academy of Medical Sciences were reviewed. RESULTS: The median age was 59 years (range 36-73); 82% of the patients were male...
July 26, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28742247/ventana-immunohistochemistry-assay-for-anaplastic-lymphoma-kinase-gene-rearrangement-detection-in-patients-with-non-small-cell-lung-cancer-a-meta-analysis
#14
Wang Zhiwei, Jiang Yuan, Yao Yihui, Hou Xin, Chen Jingtao, Shi Lei, Duan Yongjian
BACKGROUND: The aim of this study was to evaluate the diagnostic value of Ventana immunohistochemistry (IHC) assay for anaplastic lymphoma kinase (ALK) gene rearrangement screening in patients with non-small cell lung cancer (NSCLC). METHODS: Open published studies that reported the diagnostic performance of Ventana IHC assay for ALK gene rearrangement detection in NSCLC patients were extracted from PubMed, Embase, Google scholar, Wanfang, and China National Knowledge Infrastructure...
July 25, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28741868/retrospective-analysis-of-the-efficacy-and-safety-of-eribulin-therapy-for-metastatic-breast-cancer-in-daily-practice
#15
Toshihiro Tanaka, Miho Ueno, Yuta Nakashima, Shotaro Chinen, Eiichi Sato, Michio Masaki, Ai Mogi, Hidenori Sasaki, Kazuo Tamura, Yasushi Takamatsu
BACKGROUND: Evidence of eribulin therapy for metastatic breast cancer (MBC) in clinical practice is not well documented. METHODS: We retrospectively analyzed the safety and efficacy of eribulin in 29 MBC patients from 2011 to 2016 at Fukuoka University Hospital. RESULTS: The median patient age, number of courses, total dose, and relative dose intensity were as follows: 65 years, five courses, 8.6 mg/m(2) , and 75%, respectively. One patient achieved a complete response, (CR) six a partial response (PR), eight stable disease (SD) and 14 patients exhibited progressive disease...
July 25, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28731576/influence-of-trainee-involvement-on-procedural-characteristics-for-linear-endobronchial-ultrasound
#16
Sébastien Nguyen, Nancy Ferland, Stéphane Beaudoin, Simon Martel, Mathieu Simon, Francis Laberge, Noel Lampron, Marc Fortin, Antoine Delage
BACKGROUND: Linear endobronchial ultrasound (EBUS) is a safe and effective method for the diagnostic sampling of mediastinal lymph nodes. However, there is a learning curve associated with the procedure and operator experience influences diagnostic yield. We sought to determine if trainee involvement during EBUS influences procedural characteristics, complication rate, and diagnostic yield. METHODS: We performed a retrospective analysis of 220 subjects who underwent an EBUS procedure at our center from December 2012 to June 2013...
July 21, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28731531/solitary-splenic-metastasis-from-lung-adenocarcinoma-a-case-report
#17
Kantaro Hara, Nobuhiro Izumi, Takuma Tsukioka, Hiroaki Komatsu, Michihito Toda, Hikaru Miyamoto, Satoshi Suzuki, Takuya Kimura, Toshihiko Shibata, Noritoshi Nishiyama
Solitary splenic metastasis is extremely rare, with only 27 reported cases in the literature. An 81-year-old woman was referred to our hospital for treatment of pulmonary and splenic lesions. Chest computed tomography showed a small lung nodule in the right upper lobe, abdominal computed tomography showed an 8 cm splenic mass with abnormal accumulation, and positron emission tomography revealed a maximum standardized uptake value of 7.9. She had elevated serum cancer antigen 19-9 (1847 U/mL) and carcinoembryonic antigen concentrations (17...
July 21, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28727276/correlation-between-microrna-expression-clinicopathological-characteristics-and-prognosis-in-patients-with-non-small-cell-lung-cancer-a-retrospective-study
#18
Xin Wang, Yi Zhang, Xiuyi Zhi
BACKGROUND: Lung cancer prognosis is related to various factors; however, the comprehensive relationship between these factors, including microRNAs (miRNAs), and lung cancer prognosis has not been determined. Thus, the aim of this study was to identify the key factors associated with lung cancer prognosis. METHODS: We retrospectively analyzed prognosis and relevant factors in 216 non-small cell lung cancer (NSCLC) patients diagnosed from January 2008 to December 2014...
July 20, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28722216/primary-pulmonary-myxoid-sarcoma-located-in-interlobar-fissure-without-parenchymal-invasion
#19
Seok Kim, Sang Yun Song, Ju Sik Yun, Yoo Duk Choi, Kook Joo Na
Primary pulmonary myxoid sarcoma (PPMS), classified as low to intermediate grade malignant myxoid endobronchial tumor, is rarely reported. Most reported cases occurred in lung parenchyme with an endobronchial component. Herein, we report a case of PPMS in a 29-year-old woman that developed in a major fissure of the left lung without parenchymal invasion. Histopathologically, the diagnosis was compatible to PPMS with EWSR1-CREB1 translocation.
July 19, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28696575/impact-of-pulmonary-rehabilitation-on-postoperative-complications-in-patients-with-lung-cancer-and-chronic-obstructive-pulmonary-disease
#20
Hajime Saito, Kazutoshi Hatakeyama, Hayato Konno, Toshiki Matsunaga, Yoichi Shimada, Yoshihiro Minamiya
BACKGROUND: Given the extent of the surgical indications for pulmonary lobectomy in breathless patients, preoperative care and evaluation of pulmonary function are increasingly necessary. The aim of this study was to assess the contribution of preoperative pulmonary rehabilitation (PR) for reducing the incidence of postoperative pulmonary complications in non-small cell lung cancer (NSCLC) patients with chronic obstructive pulmonary disease (COPD). METHODS: The records of 116 patients with COPD, including 51 patients who received PR, were retrospectively analyzed...
July 11, 2017: Thoracic Cancer
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