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Thoracic Cancer

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https://www.readbyqxmd.com/read/28627788/risk-factors-associated-with-treatment-refusal-in-lung-cancer
#1
Won Na Suh, Kyoung Ae Kong, Yeji Han, Soo Jung Kim, Su Hwan Lee, Yon Ju Ryu, Jin Hwa Lee, Sung Shine Shim, Yookyung Kim, Jung Hyun Chang
BACKGROUND: The incidence of lung cancer is increasing with longer life expectancy. Refusal of active treatment for cancer is prone to cause patients to experience more severe symptoms and shorten survival. The purpose of this study was to define the factors related to refusal or abandonment of active therapy in lung cancer. METHODS: We retrospectively reviewed the data of 617 patients from medical records from 2010 to 2014. Two groups were formed: 149 patients who refused anti-cancer treatment and allowed only palliative care were classified into the non-treatment group, while the remaining 468 who received anti-cancer treatment were classified into the treatment group...
June 19, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28627767/clinical-significance-of-post-progression-survival-in-lung-cancer
#2
REVIEW
Hisao Imai, Kyoichi Kaira, Koichi Minato
Progression-free survival (PFS) and overall survival (OS) are two common endpoints in cancer trials. OS is usually preferred, because it is reliable, precise, meaningful, and can easily be documented. However, subsequent lines of therapy might confound the effects of first-line treatment on OS. Whether PFS or OS is the more appropriate endpoint in clinical trials of metastatic cancer remains controversial. Previous reports on lung cancer have shown that an increase in PFS does not necessarily result in an increase in OS; however, post-progression survival (PPS) is strongly associated with OS after early-line treatment...
June 19, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28608450/analysis-of-giant-thoracic-neoplasms-correlations-between-imaging-pathology-and-surgical-management
#3
Zhen Feng, Meng Li, Fang Liu, Yue Peng, Wangang Ren, Hounai Xie, Zhongmin Peng
BACKGROUND: A giant thoracic neoplasm is extremely rare and poorly understood. Our systemic study introduced computed tomography angiography (CTA) with three-dimensional (3D) reconstruction imaging and evaluated correlations between imaging, pathology, and surgical management. METHODS: Data from 45 patients undergoing surgery for giant thoracic neoplasm in our institution between May 2007 and November 2015 were collected. The clinical characteristics, imaging manifestations, preoperative biopsy, surgical management, postoperative pathology, and prognosis and their correlation were analyzed...
June 13, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28597503/prognostic-model-for-brain-metastases-from-lung-adenocarcinoma-identified-with-epidermal-growth-factor-receptor-mutation-status
#4
Hongwei Li, Weili Wang, Haixia Jia, Jianhong Lian, Jianzhong Cao, Xiaqin Zhang, Xing Song, Sufang Jia, Zhengran Li, Xing Cao, Wei Zhou, Songye Han, Weihua Yang, Yanfen Xi, Shenming Lian
BACKGROUND: Several indices have been developed to predict survival of brain metastases (BM) based on prognostic factors. However, such models were designed for general brain metastases from different kinds of cancers, and prognostic factors vary between cancers and histological subtypes. Recently, studies have indicated that epidermal growth factor receptor (EGFR) mutation status may be a potential prognostic biological factor in BM from lung adenocarcinoma. Thus, we sought to define the role of EGFR mutation in prognoses and introduce a prognostic model specific for BM from lung adenocarcinoma...
June 9, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28590585/comparison-of-the-c-met-gene-amplification-between-primary-tumor-and-metastatic-lymph-nodes-in-non-small-cell-lung-cancer
#5
Chun-Wei Xu, Wen-Xian Wang, Mei-Juan Wu, You-Cai Zhu, Wu Zhuang, Gen Lin, Kai-Qi Du, Yun-Jian Huang, Yan-Ping Chen, Gang Chen, Mei-Yu Fang
BACKGROUND: c-MET has recently been identified as a promising novel target in non-small cell lung cancer (NSCLC). We detected the consistency of c-MET gene amplification in metastatic lymph nodes and tumor tissues of NSCLC patients and discuss the clinical application value of c-MET gene amplification in metastatic lymph nodes. METHODS: Real-time fluorescent quantitative PCR was used to test tumor tissues in 368 NSCLC patients and 178 paired metastatic lymph node samples...
June 7, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28585375/intra-observer-and-inter-observer-agreements-for-the-measurement-of-dual-input-whole-tumor-computed-tomography-perfusion-in-patients-with-lung-cancer-influences-of-the-size-and-inner-air-density-of-tumors
#6
Qingle Wang, Zhiyong Zhang, Fei Shan, Yuxin Shi, Wei Xing, Liangrong Shi, Xingwei Zhang
BACKGROUND: This study was conducted to assess intra-observer and inter-observer agreements for the measurement of dual-input whole tumor computed tomography perfusion (DCTP) in patients with lung cancer. METHODS: A total of 88 patients who had undergone DCTP, which had proved a diagnosis of primary lung cancer, were divided into two groups: (i) nodules (diameter ≤3 cm) and masses (diameter >3 cm) by size, and (ii) tumors with and without air density. Pulmonary flow, bronchial flow, and pulmonary index were measured in each group...
June 6, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28574223/advantages-of-the-modified-double-ring-areolar-incision-over-the-traditional-areolar-incision-in-multicentric-breast-fibroadenoma-surgery
#7
Mingliang Zhang, Gongjin Shen, Song Zhang, Zhen Cui, Jun Qian
BACKGROUND: This study was conducted to investigate the clinical advantages of modified double ring areola incision (MDRAI) compared to ordinary areola incision (OAI) in multicentric breast fibroadenoma in women. METHODS: Sixty cases of multicentric benign breast tumor were recruited from the First Affiliated Hospital of Bengbu Medical College from January to December 2016. The cases were divided into two groups according to surgical approach: MDRAI (n = 20) and OAI (n = 40)...
June 2, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28560833/use-of-microwave-ablation-in-the-treatment-of-patients-with-multiple-primary-malignant-tumors
#8
Yue Han, Na Shao, Xiaoming Xi, Xuezhi Hao
A 56-year-old man was admitted to our hospital in 2007, complaining of an irritating cough. Computed tomography examination demonstrated a mass in the right lung and enlargement of the hilar and mediastinal lymph nodes. Small cell lung cancer was confirmed by pathological examination after fibro-bronchoscope biopsy. The patient was treated with received sequential chemotherapy and radiotherapy. Preventive radiotherapy of the whole brain was performed after complete remission of the lung disease. Seven years after diagnosis, follow-up computed tomography revealed masses in both the liver and kidney...
May 31, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28544573/spindle-cell-subtype-of-pulmonary-clear-cell-tumor-with-prominent-calcification-and-malignant-potential
#9
Yinghua Song, Fangfang Chen, Caiqing Zhang, Xiaoyan Lin
Perivascular epithelioid cell tumor of the lung, also known as clear cell "sugar" tumor, is a rare benign tumor arising from perivascular epithelioid cells. Herein, we present a case of spindle cell subtype of pulmonary perivascular epithelioid cell tumor with prominent calcification and malignant potential in a 49-year-old woman. Histologically, the striking feature of this lesion was attributed to the presence of spindle cells arranged in a diffuse pattern, which is a pitfall for diagnosis. However, some of the lesion contained polygonal tumor cells with clear abundant cytoplasm surrounded by thin-walled vascular spaces...
May 25, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28544512/interferon-induced-transmembrane-protein-3-regulates-the-growth-and-invasion-of-human-lung-adenocarcinoma
#10
Dong Zhang, Huimin Wang, Huijie He, Haiying Niu, Yu Li
BACKGROUND: Interferon induced transmembrane protein 3 (IFITM3) plays an important role in the tumorigenesis and progression of multiple cancers. This study investigated the expression and function of IFITM3 in human lung adenocarcinoma. METHODS: Fifty human lung adenocarcinoma tissues were collected. IFITM3 expression was assessed by immunohistochemical staining. The clinicopathologic characteristics of all patients were analyzed. RESULTS: IFITM3 was mainly detected in the cytoplasm of advanced cancer tissues and its expression was correlated with tumor malignancy grade...
May 23, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28544400/elevated-pretreatment-neutrophil-white-blood-cell-ratio-and-monocyte-lymphocyte-ratio-predict-poor-survival-in-patients-with-curatively-resected-non-small-cell-lung-cancer-results-from-a-large-cohort
#11
Cheng Yuan, Ning Li, Xiaoyong Mao, Zui Liu, Wei Ou, Si-Yu Wang
BACKGROUND: The prognostic values of preoperative neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) in non-small cell lung cancer (NSCLC) have been previously described. This study assessed the prognostic values of other pretreatment complete blood cell parameters in Chinese patients with curatively resected NSCLC. METHODS: A total of 1466 consecutive NSCLC patients who received curative surgery from January 1, 2005 to December 31, 2009 with complete data from pretreatment blood tests were enrolled in this retrospective study...
May 22, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28514100/microrna-128-promotes-apoptosis-in-lung-cancer-by-directly-targeting-nima-related-kinase-2
#12
Dejian Zhao, Wenzheng Han, Xia Liu, Dawei Cui, Yu Chen
BACKGROUND: MicroRNA-128 (miR-128) serves as a regulator by inducing cancer cell apoptosis, differentiation, the epithelial-to-mesenchymal transition process, and tumor growth by mediating different targets. NIMA-related kinase 2 (NEK2) is aberrantly expressed in lung cancer. The miR-128/NEK2 pathway has been reported to predict prognosis in colorectal cancer; however, the determination of a relationship between miR-128 and NEK2 in lung cancer has remained elusive. We explored the association between miR-128 and NEK2 in lung cancer...
May 17, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28509438/deguelin-inhibits-epithelial-to-mesenchymal-transition-and-metastasis-of-human-non-small-cell-lung-cancer-cells-by-regulating-nima-related-kinase-2
#13
Dejian Zhao, Wenzheng Han, Xia Liu, Dawei Cui, Yu Chen
BACKGROUND: Non-small cell lung cancer is a lethal malignancy with a high mortality rate. Deguelin displays an anti-tumor effect and inhibits metastasis in various cancers. The aberrant expression of NIMA-related kinase 2 (NEK2) indicates poor prognosis and induces epithelial-to-mesenchymal transition (EMT) and metastasis processes. However, the underlying mechanism between deguelin and NEK2 has remained elusive. METHODS: NSCLC cell lines were treated with deguelin...
May 16, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28509417/overexpression-of-ubiquitin-specific-peptidase-14-predicts-unfavorable-prognosis-in-esophageal-squamous-cell-carcinoma
#14
Baozhu Zhang, Mengqing Li, Pinzhu Huang, Xin-Yuan Guan, Ying-Hui Zhu
BACKGROUND: Ubiquitin specific peptidase 14 (USP14), a deubiquitinating enzyme, has been documented as a key element to regulate the proteolysis function of proteasomes and an attractive therapeutic target for several cancers. Herein, we elucidate the role of USP14 in predicting the prognosis of patients with esophageal squamous cell carcinoma (ESCC). METHODS: USP14 expression was detected in ESCC tissues and matched adjacent non-tumorous tissues by quantitative real-time reverse transcription-PCR and immunohistochemistry...
May 16, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28497891/does-adenomatous-polyposis-coli-gene-promoter-1a-methylation-increase-non-small-cell-lung-cancer-risk-a-meta-analysis
#15
Baoli Hu, Hangfeng Zhang, Haitao Wei, Zuopei Wang, Feng Zhang, Xiaolong Wang, Li Li
BACKGROUND: The promoter region of the adenomatous polyposis coli (APC) gene is hypermethylated in several types of cancers, including non-small cell lung cancer (NSCLC). The prevalence of methylation in the promoter region of this gene in tumor tissues and autologous controls has not been consistent in previous studies. We evaluated the frequency of APC gene promoter 1A methylation between tumor tissues and autologous controls in NSCLC patients by meta-analysis. METHODS: Open published studies of APC gene promoter 1A methylation between tumor tissues and autologous samples in NSCLC patients were identified using a systematic search...
May 12, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28474862/case-of-sclerosing-pneumocytoma-combined-with-a-typical-carcinoid-and-pulmonary-adenocarcinoma-in-different-lobes
#16
Hwa Jin Cho, Ji Hyeon Lee, Geon Kook Lee, Eun Kyung Hong, Hyae Young Kim
We report the first case of a 62-year-old man with a sclerosing pneumocytoma (SP) combined with a typical carcinoid (TC) and pulmonary adenocarcinoma in different lung lobes. Computed tomography revealed two nodules. The radiological diagnosis was primary lung cancer and a metastatic nodule; however, no enlarged lymph nodes were observed. Histological and immunohistochemical analyses defined the 1.7 cm nodule in the right upper lobe as adenocarcinoma and the 1.3 cm nodule in the left lower lobe as SP combined with TC...
May 5, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28440945/heterogeneity-in-esophageal-and-gastric-cardia-precursor-progression-during-six-year-endoscopic-surveillance-after-population-based-screening-in-a-chinese-high-risk-region
#17
Denggui Wen, Liwei Zhang, Xiaoling Wang, Xiaoduo Wen, Yi Yang, Yuetong Chen, Guiying Wang, Kohei Akazawa, Shijie Wang, Baoen Shan
BACKGROUND: The study was conducted to examine esophageal and gastric cardia precursor progression. METHODS: After population-based baseline screening, 145 precursor and 335 chronic inflammation cases were endoscopically surveyed for six years. RESULTS: Surveillance of interval and baseline diagnoses for 18 severe dysplasia (SD) cases later detected were: 13, 23, 39, and 44 months since a diagnosis of chronic inflammation in four cases; 6, 6, 6, 11, 13, 16, 16, and 23 months since mild dysplasia (mD) diagnoses in eight; and 6, 9, 10, 13, 18, and 48 months since moderate dysplasia (MD) diagnoses in six...
April 25, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28437026/analyzing-epidermal-growth-factor-receptor-mutation-status-changes-in-advanced-non-small-cell-lung-cancer-at-different-sampling-time-points-of-blood-within-one%C3%A2-day
#18
Jin Wang, Hua Bai, Chaoyu Hong, Jie Wang, Tong-Hua Mei
BACKGROUND: We investigated whether different sampling time-points within one day would influence epidermal growth factor receptor mutation (EGFRm) status in plasma and evaluated the clinical outcomes according to the quantity analysis of EGFRm in circulating tumor DNA (ctDNA) in non-small-cell lung cancer (NSCLC). METHODS: EGFR-tyrosine kinase inhibitor naïve advanced NSCLC patients who carried EGFRm in both tissues and ctDNA were enrolled in this study. Plasma samples were collected at three time-points within one day (at 8 am, 11 am and 2 pm) for EGFRm analysis by droplet digital PCR...
April 24, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28436174/endobronchial-and-transbronchial-biopsy-experience-a-united-kingdom-survey
#19
REVIEW
Janet Fallon, Andrew R L Medford
BACKGROUND: Trainees are performing fewer bronchoscopies as a result of the increased use of endobronchial ultrasound-guided transbronchial needle aspiration. Workforce planning and changes in trainee working patterns may also have compounded this situation. We investigated current trends in endobronchial biopsy (EBB) and transbronchial biopsy (TBB) training and competency in respiratory trainees and consultants across the United Kingdom. METHODS: We performed a national survey and received 131 online responses from 58 consultants and 73 registrars across 13 United Kingdom deaneries...
April 24, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28436173/relationship-between-endobronchial-ultrasound-guided-ebus-transbronchial-needle-aspiration-utility-and-computed-tomography-staging-node-size-at-ebus-and-positron-emission-tomography-scan-node-standard-uptake-values-a-retrospective-analysis
#20
Clare Marchand, Andrew R L Medford
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) diagnoses and stages mediastinal lymph node pathology. This retrospective study determined the relationship between EBUS-TBNA utility and non-small cell lung cancer (NSCLC) stage, lymph node size, and positron emission tomography (PET) standard uptake values (SUV), and the utility of neck ultrasound in bulky mediastinal disease. METHODS: Data of 284 consecutive patients who had undergone EBUS-TBNA was collected...
April 24, 2017: Thoracic Cancer
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