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Virulence

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https://www.readbyqxmd.com/read/28118093/the-influence-of-two-partner-secretion-systems-on-the-virulence-of-acinetobacter-baumannii
#1
Sarah Bigot, Suzana P Salcedo
No abstract text is available yet for this article.
January 24, 2017: Virulence
https://www.readbyqxmd.com/read/28118090/identifying-components-required-for-omp-biogenesis-as-novel-targets-for-antiinfective-drugs
#2
Johanna Weirich, Cornelia Bräutigam, Melanie Mühlenkamp, Mirita Franz-Wachtel, Boris Macek, Ina Meuskens, Mikael Skurnik, Katarzyna Leskinen, Erwin Bohn, Ingo Autenrieth, Monika Schütz
The emergence of multiresistant Gram-negative bacteria requires new therapies for combating bacterial infections. Targeting the biogenesis of virulence factors could be an alternative strategy instead of killing bacteria with antibiotics. The outer membrane (OM) of Gram-negative bacteria acts as a physical barrier. At the same time it facilitates the exchange of molecules and harbors a multitude of proteins associated with virulence. In order to insert proteins into the OM, an essential oligomeric membrane-associated protein complex, the ß-barrel assembly machinery (BAM) is required...
January 24, 2017: Virulence
https://www.readbyqxmd.com/read/28112573/persistence-of-coxsackievirus-b4-in-pancreatic-ductal-like-cells-results-in-cellular-and-viral-changes
#3
E K Alidjinou, I Engelmann, J Bossu, C Villenet, M Figeac, M B Romond, F Sané, D Hober
Introduction Although known as cytolytic viruses, group B coxackieviruses (CVB) are able to establish a persistent infection in vitro and in vivo. Viral persistence has been reported as a key mechanism in the pathogenesis of CVB-associated chronic diseases such as type 1 diabetes (T1D). The impact of CVB4 persistence on human pancreas ductal-like cells was investigated. Methods A persistent CVB4 infection was established in ductal-like cells. PDX-1 expression, resistance to CVB4-induced lysis and CAR expression were evaluated...
January 23, 2017: Virulence
https://www.readbyqxmd.com/read/28112570/tracing-a-fat-or-sweet-lifestyle-new-insights-on-catabolic-paths-of-intracellular-salmonella
#4
Magdalena Gil, Jost Enninga
No abstract text is available yet for this article.
January 23, 2017: Virulence
https://www.readbyqxmd.com/read/28103139/endotoxin-neutralization-by-an-o-antigen-specific-monoclonal-antibody-a-potential-novel-therapeutic-approach-against-klebsiella-pneumoniaest258
#5
Valéria Szijártó, Luis M Guachalla, Katharina Hartl, Cecília Varga, Adriana Badarau, Irina Mirkina, Zehra C Visram, Lukas Stulik, Christine A Power, Eszter Nagy, Gábor Nagy
Klebsiella pneumoniae ST258 is a globally distributed multi-drug resistant pathogen responsible for severe invasive infections. In this study, the different virulence potential of K. pneumoniae ST258 isolates in endotoxin susceptible versus resistant animal models was shown. Furthermore, ST258 clinical isolates were found highly sensitive to the bactericidal effect of naive animal and human serum. These observations imply that LPS, released from the rapidly lysed bacteria, may contribute to the high mortality associated with ST258 bacteremia cases...
January 19, 2017: Virulence
https://www.readbyqxmd.com/read/28102784/model-systems-for-the-study-of-enterococcal-colonization-and-infection
#6
H M Sharon Goh, M H Adeline Yong, Kelvin Kian Long Chong, Kimberly A Kline
Enterococcus faecalis and Enterococcus faecium are common inhabitants of the human gastrointestinal tract, as well as frequent opportunistic pathogens. Enterococci cause a range of infections including, most frequently, infections of the urinary tract, catheterized urinary tract, bloodstream, wounds and surgical sites, and heart valves in endocarditis. Enterococcal infections are often biofilm-associated, polymicrobial in nature, and resistant to antibiotics of last resort. Understanding Enterococcal mechanisms of colonization and pathogenesis are important for identifying new ways to manage and intervene with these infections...
January 19, 2017: Virulence
https://www.readbyqxmd.com/read/28102766/soluble-p-selectin-rescues-mice-from-anthrax-lethal-toxin-induced-mortality-through-psgl-1-pathway-mediated-correction-of-hemostasis
#7
Der-Shan Sun, Yao-Wen Chang, Jyh-Hwa Kau, Hsin-Hsien Huang, Pei-Hsun Ho, Yin-Jeh Tzeng, Hsin-Hou Chang
As one of the virulence factors of Bacillus anthracis, lethal toxin (LT) induces various pathogenic responses including the suppression of the coagulation system. In this study, we observed that LT markedly increased the circulating soluble P-selectin (sP-sel) levels and microparticle (MP) count in wild-type but not P-selectin (P-sel, Selp(-)(-)(-)) or P-sel ligand-1 (PSGL-1, Selplg(-)(-)(-)) knockout mice. Because sP-sel induces a hypercoagulable state through PSGL-1 pathway to generate tissue factor-positive MPs, we hypothesized that the increase in plasma sP-sel levels can be a self-rescue response in hosts against the LT-mediated suppression of the coagulation system...
January 19, 2017: Virulence
https://www.readbyqxmd.com/read/28102763/the-best-defense-is-a-good-protease-offense-how-pseudomonas-aeruginosa-evades-mucosal-immunity-in-the-lung
#8
Lisa A Miller
No abstract text is available yet for this article.
January 19, 2017: Virulence
https://www.readbyqxmd.com/read/28102762/the-emerging-importance-and-challenges-of-the-human-mycobiome
#9
Heidi H Kong, Alison Morris
No abstract text is available yet for this article.
January 19, 2017: Virulence
https://www.readbyqxmd.com/read/28102761/virulent-nontyphoidal-salmonella-producing-ctx-m-and-cmy-2-%C3%AE-lactamases-from-livestock-food-and-human-infection-brazil
#10
Quézia Moura, Miriam R Fernandes, Ketrin C Silva, Daniel F Monte, Fernanda Esposito, Milena Dropa, César Noronha, Andrea M Moreno, Mariza Landgraf, Fábio J Negrão, Nilton Lincopan
No abstract text is available yet for this article.
January 19, 2017: Virulence
https://www.readbyqxmd.com/read/28095189/the-unmet-clinical-need-of-novel-antifungal-drugs
#11
Damian J Krysan
No abstract text is available yet for this article.
January 17, 2017: Virulence
https://www.readbyqxmd.com/read/28075229/altered-mitochondrial-dynamics-as-a-consequence-of-venezuelan-equine-encephalitis-virus-infection
#12
Forrest Keck, Taryn Brooks-Faulconer, Tyler Lark, Pavitra Ravishankar, Charles Bailey, Carolina Salvador-Morales, Aarthi Narayanan
Mitochondria are sentinel organelles that are impacted by various forms of cellular stress, including viral infections. While signaling events associated with mitochondria, including those activated by pathogen associated molecular patterns (PAMPs), are widely studied, alterations in mitochondrial distribution and changes in mitochondrial dynamics are also beginning to be associated with cellular insult. Cells of neuronal origin have been demonstrated to display remarkable alterations in several instances, including neurodegenerative disorders...
January 11, 2017: Virulence
https://www.readbyqxmd.com/read/28060574/the-hcp-proteins-fused-with-diverse-extended-toxin-domains-represent-a-novel-pattern-of-antibacterial-effectors-in-type-vi-secretion-systems
#13
Jiale Ma, Zihao Pan, Jinhu Huang, Min Sun, Chengping Lu, Huochun Yao
The type VI secretion system (T6SS) is a widespread molecular weapon deployed by many bacterial species to target eukaryotic host cells or rival bacteria. Using a dynamic injection mechanism, diverse effectors can be delivered by T6SS directly into recipient cells. Here, we report a new family of T6SS effectors encoded by extended Hcps carrying diverse toxin domains. Bioinformatic analyses revealed that these Hcps with C-terminal extension toxins, designated as Hcp-ET, exist widely in the Enterobacteriaceae...
January 6, 2017: Virulence
https://www.readbyqxmd.com/read/28060573/francisella-tularensis-type-vi-secretion-system-comes-of-age
#14
Petra Spidlova, Jiri Stulik
No abstract text is available yet for this article.
January 6, 2017: Virulence
https://www.readbyqxmd.com/read/28060571/m-ficolin-is-present-in-aspergillus-fumigatus-infected-lung-and-modulates-epithelial-cell-immune-responses-elicited-by-fungal-cell-wall-polysaccharides
#15
Kasper Jensen, Kit P Lund, Kimmie B Christensen, Anne T Holm, Lalit Kumar Dubey, Jesper B Moeller, Christine S Jepsen, Anders Schlosser, László Galgóczy, Steffen Thiel, Uffe Holmskov, Grith L Sorensen
Aspergillus fumigatus (A. fumigatus) is an opportunistic fungal pathogen that typically infects the lungs of immunocompromised patients. Ficolins are secreted pattern recognition molecules of the innate immune system. In the present study, we investigated the unknown role of human M-ficolin in the recognition of, and response to fungal cell wall polysaccharides. M-ficolin was localized to infiltrating granulocytes and monocytes found in the A. fumigatus infected lung. Recombinant M-ficolin (rM-ficolin) bound specifically to A...
January 6, 2017: Virulence
https://www.readbyqxmd.com/read/28059611/molecular-characterization-of-pneumococcal-surface-protein-k-a-potential-pneumococcal-vaccine-antigen
#16
A-Yeung Jang, Ho Seong Seo, Shunmei Lim, Gook-Hyun Chung, Han Wool Kim, Sangyong Lim, Lei Zhao, In-Ho Park, Jae Hyang Lim, Kyung-Hyo Kim
The pneumococcal capsule is indispensable for pathogenesis in systemic infections; however, many pneumococcal diseases, including conjunctivitis, otitis media, and some systemic infections in immunocompromised patients, are caused by nonencapsulated Streptococcus pneumoniae (NESp). Null capsule clade 1 (NCC1), found in group 2 NESp, expresses pneumococcal surface protein K (PspK) and is becoming prevalent among pneumococcal organisms owing to the widespread use of pneumococcal conjugate vaccines. Despite its clinical importance, the molecular mechanisms underlying the prevalence of NCC1 have not been fully elucidated...
January 6, 2017: Virulence
https://www.readbyqxmd.com/read/28051916/the-antimicrobial-effect-of-blue-light-what-are-behind
#17
Tianhong Dai
No abstract text is available yet for this article.
January 4, 2017: Virulence
https://www.readbyqxmd.com/read/28051908/antimicrobial-capacity-of-the-freshwater-planarians-against-s-aureus-is-under-the-control-of-timeless
#18
Landry Laure Tsoumtsa, Cedric Torre, Virginie Trouplin, Benjamin Coiffard, Gregory Gimenez, Jean-Louis Mege, Eric Ghigo
Planarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the circadian machinery in the anti-bacterial response of the freshwater planarian Schmidtea mediterranea. We identified Smed-Tim from S. mediterranea as a homolog of the mammalian clock gene Tim. We showed via RNA interference that Smed-Tim is required for the anti-microbial activities of Schmidtea mediterranea against Staphylococcus aureus infection during the light/dark cycle...
January 4, 2017: Virulence
https://www.readbyqxmd.com/read/28033037/importance-of-strain-lineages-for-group-b-streptococcal-survival
#19
Bryan M Hancock, Kelly S Doran
No abstract text is available yet for this article.
December 29, 2016: Virulence
https://www.readbyqxmd.com/read/27960650/first-report-of-htlv-1-truncated-p12-protein-in-brazil
#20
Carolina Rosadas, Ana C P Vicente, Louise Zanella, Mauro J Cabral-Castro, José M Peralta, Marzia Puccioni-Sohler
No abstract text is available yet for this article.
December 14, 2016: Virulence
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