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Virulence

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https://www.readbyqxmd.com/read/28328284/non-encapsulated-streptococcus-pneumoniae-vaccination-as-a-measure-to-interfere-with-horizontal-gene-transfer
#1
J D Langereis, M I de Jonge
No abstract text is available yet for this article.
March 22, 2017: Virulence
https://www.readbyqxmd.com/read/28324675/arterial-stiffness-in-hiv-infected-youth-and-associations-with-hiv-related-variables
#2
Allison Ross Eckard, Paolo Raggi, Joshua H Ruff, Mary Ann O'Riordan, Julia C Rosebush, Danielle Labbato, Julie E Daniels, Monika Uribe-Leitz, Christopher T Longencker, Grace A McComsey
Children and young adults infected with HIV are at elevated risk for cardiovascular disease (CVD). However, scarce data exist on the utility of non-invasive methods to diagnose subclinical CVD, such as pulse wave velocity (PWV), a non-invasive measure of arterial stiffness. The objectives of this study were to assess the relationship of carotid-femoral PWV with subclinical atherosclerosis measured by carotid intima-media thickness (IMT), compare measurements to healthy controls, and evaluate variables associated with PWV in HIV-infected youth...
March 21, 2017: Virulence
https://www.readbyqxmd.com/read/28323523/rapid-dna-vaccination-against-burkholderia-pseudomallei-flagellin-by-tattoo-or-intranasal-application
#3
Jacqueline M Lankelma, Alex Wagemakers, Emma Birnie, Bastiaan W Haak, Jos J A Trentelman, Tassili A F Weehuizen, Jasmin Ersöz, Joris J T H Roelofs, Joppe W Hovius, W Joost Wiersinga, Adriaan D Bins
Melioidosis is a severe infectious disease with a high mortality that is endemic in South-East Asia and Northern Australia. The causative pathogen, Burkholderia pseudomallei, is listed as potential bioterror weapon due to its high virulence and potential for easy dissemination. Currently, there is no licensed vaccine for prevention of melioidosis. Here, we explore the use of rapid plasmid DNA vaccination against B. pseudomallei flagellin for protection against respiratory challenge. We tested three flagellin DNA vaccines with different subcellular targeting designs...
March 21, 2017: Virulence
https://www.readbyqxmd.com/read/28306387/help-is-on-the-way-monoclonal-antibody-therapy-for-multi-drug-resistant-bacteria
#4
Rachelle Babb, Liise-Anne Pirofski
No abstract text is available yet for this article.
March 17, 2017: Virulence
https://www.readbyqxmd.com/read/28296562/immunomodulatory-yersinia-outer-proteins-yops-useful-tools-for-bacteria-and-humans-alike
#5
Benjamin Grabowski, M Alexander Schmidt, Christian Rüter
Human-pathogenic Yersinia produce plasmid-encoded Yersinia outer proteins (Yops), which are necessary to down-regulate anti-bacterial responses that constrict bacterial survival in the host. These Yops are effectively translocated directly from the bacterial into the target cell cytosol by the type III secretion system (T3SS). Cell-penetrating peptides (CPPs) in contrast are characterized by their ability to autonomously cross cell membranes and to transport cargo - independent of additional translocation systems...
March 15, 2017: Virulence
https://www.readbyqxmd.com/read/28287893/aging-metabolism-intervention-strategies
#6
Esteban Martinez
Human beings are subjected to aging and age-associated diseases. Life expectancy has improved impressively in the last century due to social and economic development, but despite increasing improvement is still more limited than average in those ones with chronic diseases such as treated HIV infection. There has been a substantial research on the underlying factors responsible for aging both in the general and the HIV-infected populations. Several specific targets for potential intervention have been identified but studies so far have been limited to small experiments in cultured cells or living beings other than humans such as mice or flies...
March 13, 2017: Virulence
https://www.readbyqxmd.com/read/28281892/self-defense-against-bacillus-anthracis-toxins-is-p-selectin-the-key
#7
John D Campbell
No abstract text is available yet for this article.
March 10, 2017: Virulence
https://www.readbyqxmd.com/read/28267417/staphylococcus-aureus-toxin-antibodies-good-companions-of-antibiotics-and-vaccines
#8
Fabio Bagnoli
No abstract text is available yet for this article.
March 7, 2017: Virulence
https://www.readbyqxmd.com/read/28267407/the-evolving-relationship-between-adiponectin-and-insulin-sensitivity-in-hepatitis-c-patients-during-viral-clearance
#9
Ming-Ling Chang, Chia-Jung Kuo, Li-Heng Pao, Chen-Ming Hsu, Cheng-Tang Chiu
BACKGROUND: The evolution of the relationship between adiponectin and insulin sensitivity in hepatitis C virus (HCV) patients during viral clearance is unclear and warrants investigation. METHODS: A prospective study including 747 consecutive chronic hepatitis C (CHC) patients, of whom 546 had completed a course of anti-HCV therapy and underwent pre-, peri- and post-therapy surveys for anthropomorphic, viral, metabolic and hepatic profiles and adiponectin levels, was conducted in a tertiary care center...
March 7, 2017: Virulence
https://www.readbyqxmd.com/read/28277898/planarian-finds-time-less-to-fight-infection
#10
Óscar Gutiérrez-Gutiérrez, Daniel A Felix, Cristina González-Estévez
In this issue of Virulence, Tsoumtsa et al. (2017) investigate how timeless, a component of the circadian clock, regulates planarian immune response to Staphylococcus aureus.
March 2, 2017: Virulence
https://www.readbyqxmd.com/read/28277899/don-t-judge-a-book-by-its-cover-the-hcps-are-not-only-structural-components-of-the-t6ss-machinery
#11
Sophie Bleves
No abstract text is available yet for this article.
March 1, 2017: Virulence
https://www.readbyqxmd.com/read/28276993/infections-caused-by-carbapenem-resistant-klebsiella-pneumoniae-with-hypermucoviscous-phenotype-a-case-report-and-literature-review
#12
Fabio Arena, Lucia Henrici De Angelis, Marco Maria D'Andrea, Antonio Cannatelli, Lucina Fossati, Vincenzo Di Pilato, Tommaso Giani, Rossana Cavallo, Gian Maria Rossolini
No abstract text is available yet for this article.
February 23, 2017: Virulence
https://www.readbyqxmd.com/read/28277900/influence-of-maternal-vaccination-against-diphtheria-tetanus-and-pertussis-on-the-avidity-of-infant-antibody-responses-to-a-pertussis-containing-vaccine-in-belgium
#13
Raïssa Nadège Caboré, Kirsten Maertens, Alexandre Dobly, Elke Leuridan, Pierre Van Damme, Kris Huygen
Maternal antibodies induced by vaccination during pregnancy cross the placental barrier and can close the susceptibility gap to pertussis in young infants up to the start of primary immunization. As not only the quantity but also the quality of circulating antibodies is important for protection, we assessed whether maternal immunization affects the avidity of infant vaccine-induced IgG antibodies, in the frame of a prospective clinical trial on pregnancy vaccination in Belgium. Infants born from Tdap (Boostrix®) vaccinated (N = 55) and unvaccinated (N = 26) mothers were immunized with a hexavalent pertussis containing vaccine (Infanrix Hexa®) at 8, 12 and 16 weeks, followed by a fourth dose at 15 months of age...
February 22, 2017: Virulence
https://www.readbyqxmd.com/read/28276994/immunosenescence-and-hurdles-in-the-clinical-management-of-older-hiv-patients
#14
Marco Ripa, Stefania Chiappetta, Giuseppe Tambussi
People living with HIV (PLWH) who are treated with effective highly active antiretroviral therapy (HAART) have a similar life expectancy to the general population. Moreover, an increasing proportion of new HIV diagnoses are made in people older than 50 y. The number of older HIV-infected patients is thus constantly growing and it is expected that by 2030 around 70% of PLWH will be more than 50 y old. On the other hand, HIV infection itself is responsible for accelerated immunosenescence, a progressive decline of immune system function in both the adaptive and the innate arm, which impairs the ability of an individual to respond to infections and to give rise to long-term immunity; furthermore, older patients tend to have a worse immunological response to HAART...
February 21, 2017: Virulence
https://www.readbyqxmd.com/read/28277902/interfering-with-outer-membrane-biogenesis-to-fight-gram-negative-bacterial-pathogens
#15
Raffaele Ieva
No abstract text is available yet for this article.
February 17, 2017: Virulence
https://www.readbyqxmd.com/read/28277901/virulence-profiles-debabrata-biswas
#16
Debabrata Biswas
No abstract text is available yet for this article.
February 17, 2017: Virulence
https://www.readbyqxmd.com/read/28277903/a-human-monoclonal-antibody-that-specifically-binds-and-inhibits-the-staphylococcal-complement-inhibitor-protein-scin
#17
Hedzer Hoekstra, Francisco Romero Pastrana, Hendrik P J Bonarius, Kok P M van Kessel, Goffe S Elsinga, Neeltje Kooi, Herman Groen, Jan Maarten van Dijl, Girbe Buist
Staphylococcus aureus is a serious public health burden causing a wide variety of infections. Earlier detection of such infections could result in faster and more directed therapies that also prevent resistance development. Human monoclonal antibodies (humAbs) are promising tools for diagnosis and therapy owing to their relatively straightforward synthesis, long history of safe clinical use and high target specificity. Here we show that the humAb 6D4, which was obtained from a random screen of B-cells producing antibodies that bind to whole cells of S...
February 16, 2017: Virulence
https://www.readbyqxmd.com/read/28272976/cathelicidin-peptide-rescues-g-mellonella-infected-with-b-anthracis
#18
Ryan J Blower, Serguei G Popov, Monique L van Hoek
No abstract text is available yet for this article.
February 16, 2017: Virulence
https://www.readbyqxmd.com/read/28276995/monoclonal-antibodies-and-bacterial-virulence
#19
Mirella Luciani, Luigi Iannetti
No abstract text is available yet for this article.
February 10, 2017: Virulence
https://www.readbyqxmd.com/read/28277904/genome-wide-functional-analysis-in-candida-albicans
#20
Thabiso E Motaung, Ruan Ells, Carolina H Pohl, Jacobus Albertyn, Toi J Tsilo
Candida albicans is an important etiological agent of superficial and life-threatening infections in individuals with compromised immune systems. To date, we know of several overlapping genetic networks that govern virulence attributes in this fungal pathogen. Classical use of deletion mutants has led to the discovery of numerous virulence factors over the years, and genome-wide functional analysis has propelled gene discovery at an even faster pace. Indeed, a number of recent studies using large-scale genetic screens followed by genome-wide functional analysis has allowed for the unbiased discovery of many new genes involved in C...
February 8, 2017: Virulence
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