journal
MENU ▼
Read by QxMD icon Read
search

Virulence

journal
https://www.readbyqxmd.com/read/29781374/april-and-staci-could-be-predictors-of-severe-multiorgan-dysfunction-syndrome-in-sepsis
#1
Dajana F Lendak, Dunja M Mihajlović, Aleksandra S Novakov-Mikić, Jasmina M Boban, Milan Ubavić, Snežana V Brkić
Although the role of B cells in sepsis immunoregulation has become an interesting topic, there is lack of data on the role of B cell function regulators in prediction of multiorgan dysfunction syndrome (MODS). The aim of this study was to evaluate the prognostic value of A Proliferation Inducing Ligand (APRIL) and soluble Transmembrane Activator and CAML Interactor Protein (sTACI), the main B cell function regulators, in prediction of MODS development within the first 48h after admission to intensive care unit, among septic patients...
May 21, 2018: Virulence
https://www.readbyqxmd.com/read/29768087/corrigendum
#2
Hong-Yu Ou
No abstract text is available yet for this article.
May 16, 2018: Virulence
https://www.readbyqxmd.com/read/29697309/comprehensive-identification-of-vibrio-vulnificus-genes-required-for-growth-in-human-serum
#3
M Carda-Diéguez, F X Silva-Hernández, T P Hubbard, M C Chao, M K Waldor, C Amaro
Vibrio vulnificus can be a highly invasive pathogen capable of spreading from an infection site to the bloodstream, causing sepsis and death. To survive and proliferate in blood, the pathogen requires mechanisms to overcome the innate immune defenses and metabolic limitations of this host niche. We created a high-density transposon mutant library in YJ016, a strain representative of the most virulent V. vulnificus lineage (or phylogroup) and used transposon insertion sequencing (TIS) screens to identify loci that enable the pathogen to survive and proliferate in human serum...
April 26, 2018: Virulence
https://www.readbyqxmd.com/read/29683763/saccharomyces-cerevisiae-based-probiotic-as-novel-anti-microbial-agent-for-therapy-of-bacterial-vaginosis
#4
Samuele Sabbatini, Claudia Monari, Nathalie Ballet, Paolo Mosci, Amélie Cayzeele Decherfe Fanny Pélerin, Stefano Perito, Paolo Scarpelli, Anna Vecchiarelli
In this study, we demonstrate, for the first time, that Saccharomyces cerevisiae-based probiotic shows an inhibitory effect on Gardnerella vaginalis infection. This effect is likely due to several actions: direct interference with adherence to vaginal tissues, inhibition of sialidase activity, reduction of vaginal epithelial exfoliation. Gardnerella vaginalis does not induce vaginal inflammation and no inflammatory cytokines were, indeed, produced, by the mouse vagina, neither by Gardnerella vaginalis and by the probiotic...
April 23, 2018: Virulence
https://www.readbyqxmd.com/read/29683762/regulation-of-hemolysin-in-uropathogenic-escherichia-coli-fine-tunes-killing-of-human-macrophages
#5
Ambika M V Murthy, Minh-Duy Phan, Kate M Peters, Nguyen Thi Khanh Nhu, Rodney A Welch, Glen C Ulett, Mark A Schembri, Matthew J Sweet
Uropathogenic E. coli (UPEC) causes the majority of urinary tract infections (UTIs), which are a major global public health concern. UPEC uses numerous mechanisms to subvert the innate immune system, including targeting macrophage functions. We recently showed that some UPEC strains rapidly kill human macrophages via an NLRP3-independent pathway, and also trigger NLRP3-dependent IL-1β processing. In this study, we used random transposon mutagenesis in the reference strain CFT073 to identify UPEC genes that mediate human macrophage cell death...
April 23, 2018: Virulence
https://www.readbyqxmd.com/read/29667494/discovery-of-a-mcr-1-bearing-plasmid-in-commensal-colistin-resistant-escherichia-coli-from-healthy-broilers-in-faisalabad-pakistan
#6
Jiali Lv, Mashkoor Mohsin, Sheng Lei, Swaminath Srinivas, Raja Talish Wiqar, Jingxia Lin, Youjun Feng
No abstract text is available yet for this article.
April 18, 2018: Virulence
https://www.readbyqxmd.com/read/29638195/editorial-o-specific-polysaccharide-confers-lysozyme-resistance-to-extraintestinal-pathogenic-escherichia-coli
#7
Jolanta Lukasiewicz, Czeslaw Lugowski
No abstract text is available yet for this article.
April 11, 2018: Virulence
https://www.readbyqxmd.com/read/29638186/helicobacter-suis-binding-to-carbohydrates-on-human-and-porcine-gastric-mucins-and-glycolipids-occurs-via-two-modes
#8
Médea Padra, Barbara Adamczyk, John Benktander, Bram Flahou, Emma C Skoog, János Tamás Padra, Annemieke Smet, Chunsheng Jin, Richard Ducatelle, Tore Samuelsson, Freddy Haesebrouck, Niclas G Karlsson, Susann Teneberg, Sara K Lindén
Helicobacter suis colonizes the stomach of most pigs and is the most prevalent non-Helicobacter pylori Helicobacter species found in the human stomach. In the human host, H. suis contributes to the development of chronic gastritis, peptic ulcer disease and MALT lymphoma, whereas in pigs it is associated with gastritis, decreased growth and ulcers. Here, we demonstrate that the level of H. pylori and H. suis binding to human and pig gastric mucins varies between individuals with species dependent specificity...
April 11, 2018: Virulence
https://www.readbyqxmd.com/read/29638177/phenotypic-changes-associated-with-colistin-resistance-due-to-lipopolysaccharide-loss-in-acinetobacter-baumannii
#9
Marta Carretero-Ledesma, Meritxell García-Quintanilla, Reyes Martín-Peña, Marina R Pulido, Jerónimo Pachón, Michael J McConnell
Acinetobacter baumannii can acquire resistance to colistin via complete loss of lipopolysaccharide (LPS) biosynthesis due to mutations in the lpxA, lpxC and lpxD genes. However, although colistin is increasingly being used for the treatment of multidrug resistant infections, very few A. baumannii clinical isolates develop colistin resistance through loss of LPS biosynthesis. This may suggest that LPS loss affects virulence traits that play a role in the transmission and pathogenesis of A. baumannii. In this study we characterize multiple virulence phenotypes of colistin resistant, LPS-deficient derivatives of the ATCC 19606 strain and five multidrug resistant clinical isolates and their colistin resistant, LPS-deficient derivatives...
April 11, 2018: Virulence
https://www.readbyqxmd.com/read/29638173/differential-expression-of-hemoglobin-receptor-hmbr-between-carriage-and-invasive-isolates-of-neisseria-meningitidis-contributes-to-virulence-lessons-from-a-clonal-outbreak
#10
Julien Sevestre, Seydina M Diene, Myriam Aouiti-Trabelsi, Ala-Eddine Deghmane, Isabelle Tournier, Patrice François, François Caron, Muhamed-Kheir Taha
Carriage and invasion balance in the pathogenesis of Neisseria meningitidis was analyzed during a recent clonal outbreak of meningococcal B in Normandy, France, that offered the opportunity to compare six isolates undistinguable by conventional typing (B:P1.7,16:F3-3/ST-32) isolated from invasive disease or pharyngeal asymptomatic carriage. Data from animal model (transgenic mice rendered susceptible to N. meningitidis infection) showed an absence of virulence for two non-capsulated carriage isolates, an intermediate virulence for two capsulated carriage isolates and a marked virulence for two capsulated invasive isolates...
April 11, 2018: Virulence
https://www.readbyqxmd.com/read/29616874/porphyromonas-gingivalis-traffics-into-endoplasmic-reticulum-rich-autophagosomes-for-successful-survival-in-human-gingival-epithelial-cells
#11
Kyulim Lee, JoAnn S Roberts, Chul Hee Choi, Kalina R Atanasova, Özlem Yilmaz
Porphyromonas gingivalis, an opportunistic pathogen usurps gingival epithelial cells (GECs) as primary intracellular niche for its colonization in the oral mucosa. However, the precise characterization of the intracellular trafficking and fate of P. gingivalis in GECs remains incomplete. Therefore, we employed high-resolution three-dimensional-transmission-electron-microscopy to determine the subcellular location of P. gingivalis in human primary GECs upon invasion. Serial sections of infected-GECs and their tomographic reconstruction depicted ER-rich-double-membrane autophagosomal-vacuoles harboring P...
April 4, 2018: Virulence
https://www.readbyqxmd.com/read/29532714/turning-on-virulence-mechanisms-that-underpin-the-morphologic-transition-and-pathogenicity-of-blastomyces
#12
Joseph A McBride, Gregory M Gauthier, Bruce S Klein
This review article focuses on the mechanisms underlying temperature adaptation and virulence of the etiologic agents of blastomycosis, Blastomyces dermatitidis, Blastomyces gilchristii, and Blastomyces percursus. In response to temperature, Blastomyces undergoes a reversible morphologic switch between hyphae and yeast known as the phase transition. The conversion to yeast for Blastomyces and related thermally dimorphic fungi is essential for virulence. In the yeast phase, Blastomyces upregulates the essential virulence factor, BAD1, which promotes attachment to host cells, impairs activation of immune cells, and blunts cytokine release...
March 13, 2018: Virulence
https://www.readbyqxmd.com/read/29726306/secreted-giardia-intestinalis-cysteine-proteases-disrupt-intestinal-epithelial-cell-junctional-complexes-and-degrade-chemokines
#13
Jingyi Liu, Showgy Ma'ayeh, Dimitra Peirasmaki, Britta Lundström-Stadelmann, Lars Hellman, Staffan G Svärd
Giardiasis is a common diarrheal disease caused by the protozoan parasite Giardia intestinalis. Cysteine proteases (CPs) are acknowledged as virulence factors in Giardia but their specific role in the molecular pathogenesis of disease is not known. Herein, we aimed to characterize the three main secreted CPs (CP14019, CP16160 and CP16779), which were identified by mass spectrometry in the medium during interaction with intestinal epithelial cells (IECs) in vitro. First, the CPs were epitope-tagged and localized to the endoplasmic reticulum and cytoplasmic vesicle-like structures...
December 31, 2018: Virulence
https://www.readbyqxmd.com/read/29726301/identification-and-characterization-of-orf19-1725-a-novel-gene-contributing-to-the-white-cell-pheromone-response-and-virulence-associated-functions-in-candida-albicans
#14
Fu-Sheng Deng, Ching-Hsuan Lin
An epigenetic transition between white cells and opaque cells influences several properties of Candida albicans biology, including cellular morphology, biofilm formation, virulence, and sexual mating. In particular, these two cell types exhibit marked differences in their ability to undergo sex. A previous study identified the transcriptional regulator of pheromone response in both the white and opaque states as Cph1 because deletion of this gene abolished both pheromone-induced cell adhesion in white cells and sexual mating in opaque cells...
December 31, 2018: Virulence
https://www.readbyqxmd.com/read/29726300/generous-hosts-why-the-larvae-of-greater-wax-moth-galleria-mellonella-is-a-perfect-infectious-host-model
#15
Nabil Killiny
No abstract text is available yet for this article.
December 31, 2018: Virulence
https://www.readbyqxmd.com/read/29683780/emergence-of-the-third-generation-cephalosporin-resistant-hypervirulent-klebsiella-pneumoniae-due-to-the-acquisition-of-a-self-transferable-bla-dha-1-carrying-plasmid-by-an-st23-strain
#16
Yingzhou Xie, Lijun Tian, Gang Li, Hongping Qu, Jingyong Sun, Wei Liang, Xiaobin Li, Xiaoli Wang, Zixin Deng, Jialin Liu, Hong-Yu Ou
No abstract text is available yet for this article.
December 31, 2018: Virulence
https://www.readbyqxmd.com/read/29560793/extracellular-vesicles-and-vesicle-free-secretome-of-the-protozoa-acanthamoeba-castellanii-under-homeostasis-and-nutritional-stress-and-their-damaging-potential-to-host-cells
#17
Diego de Souza Gonçalves, Marina da Silva Ferreira, Susie Coutinho Liedke, Kamilla Xavier Gomes, Gabriel Afonso de Oliveira, Pedro Ernesto Lopes Leão, Gabriele Vargas Cesar, Sergio H Seabra, Juliana Reis Cortines, Arturo Casadevall, Leonardo Nimrichter, Gilberto Barbosa Domont, Magno Rodrigues Junqueira, Jose Mauro Peralta, Allan J Guimaraes
Acanthamoeba castellanii (Ac) are ubiquitously distributed in nature, and by contaminating medical devices such as heart valves and contact lenses, they cause a broad range of clinical presentations to humans. Although several molecules have been described to play a role in Ac pathogenesis, including parasite host-tissue invasion and escaping of host-defense, little information is available on their mechanisms of secretion. Herein, we describe the molecular components secreted by Ac, under different protein availability conditions to simulate host niches...
December 31, 2018: Virulence
https://www.readbyqxmd.com/read/29532717/pyoverdine-a-siderophore-from-pseudomonas-aeruginosa-translocates-into-c-elegans-removes-iron-and-activates-a-distinct-host-response
#18
Donghoon Kang, Daniel R Kirienko, Phillip Webster, Alfred L Fisher, Natalia V Kirienko
Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy...
December 31, 2018: Virulence
https://www.readbyqxmd.com/read/29532715/importin-%C3%AE-5-negatively-regulates-importin-%C3%AE-1-mediated-nuclear-import-of-newcastle-disease-virus-matrix-protein-and-viral-replication-and-pathogenicity-in-chicken-fibroblasts
#19
Zhiqiang Duan, Haixu Xu, Xinqin Ji, Jiafu Zhao, Houqiang Xu, Yan Hu, Shanshan Deng, Shunlin Hu, Xiufan Liu
The matrix (M) protein of Newcastle disease virus (NDV) is demonstrated to localize in the nucleus via intrinsic nuclear localization signal (NLS), but cellular proteins involved in the nuclear import of NDV M protein and the role of M's nuclear localization in the replication and pathogenicity of NDV remain unclear. In this study, importin β1 was screened to interact with NDV M protein by yeast two-hybrid screening. This interaction was subsequently confirmed by co-immunoprecipitation and pull-down assays...
December 31, 2018: Virulence
https://www.readbyqxmd.com/read/29532702/a-unique-cytoskeleton-associated-protein-in-cryptococcus-neoformans
#20
EDITORIAL
Angie Gelli
No abstract text is available yet for this article.
December 31, 2018: Virulence
journal
journal
43028
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"