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Oncology Letters

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https://www.readbyqxmd.com/read/30034553/expression-of-bancr-promotes-papillary-thyroid-cancer-by-targeting-thyroid-stimulating-hormone-receptor
#1
Haitao Zheng, Jie Xu, Shaolong Hao, Xincheng Liu, Jinrao Ning, Xicheng Song, Lixin Jiang, Zongying Liu
Papillary thyroid carcinoma (PTC) is the most common form of non-medullary thyroid cancer, accounting for ~80% of all cases of thyroid cancer. The aim of the present study was to explore the role of BRAF-activated long noncoding RNA (BANCR) in the development of PTC. Using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), the mRNA expression levels of BANCR, thyroid-stimulating hormone receptor (TSHR) and cyclin D1 between PTC and benign control thyroid nodule tissue samples from 60 patients were determined...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30034552/effect-of-derris-scandens-extract-on-a-human-hepatocellular-carcinoma-cell-line
#2
Duanghathai Kuljittichanok, Penchatr Diskul-Na-Ayudthaya, Churat Weeraphan, Daranee Chokchaichamnankit, Khajeelak Chiablaem, Kriengsak Lirdprapamongkol, Jisnuson Svasti, Chantragan Srisomsap
The incidence rate of hepatocellular carcinoma (HCC) remains high in numerous countries, including Thailand. There are numerous different lines of HCC treatment; however, various side effects and the resistance of cancer cells during treatment remain issues. At present, traditionally used herb plants have been widely used as alternatives to cancer therapy. Derris scandens is a Thai traditional herb which is commonly found in Thailand and widely used as a traditional medicine for numerous different diseases...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013672/the-link-between-foxj1-expression-level-in-bladder-carcinoma-and-tumor-recurrence
#3
Bing Liang, Xinwei He, Donghao Shang, Ye Tian, Zongwen Liu
[This retracts the article DOI: 10.3892/ol.2017.7504.].
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013671/elucidating-feed-forward-apoptosis-signatures-in-breast-cancer-datasets-higher-fos-expression-associated-with-a-better-outcome
#4
Diana A Fisler, Dhiraj Sikaria, John M Yavorski, Yaping N Tu, George Blanck
Overstimulation of pro-proliferative pathways and high level expression of pro-proliferative transcription factors (TFs) can lead to apoptosis. This is likely due to TF binding sites for pro-proliferative TFs common to pro-proliferative and pro-apoptosis-effector genes. Certain clinical datasets have indicated that molecular markers associated with higher proliferation rates lead to improved outcomes for patients with cancer. These observations have been extensively assessed on a general basis, however there has been little work dissecting feed-forward apoptosis signaling pathways that may represent specific distinctions between a pro-proliferative mechanism and a pro-apoptotic mechanism in samples from patients with cancer...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013670/identification-of-long-non-coding-rna-ccat1-as-an-oncogene-in-nasopharyngeal-carcinoma
#5
Yameng Dong, Haozhan Yuan, Guangyu Jin
Nasopharyngeal carcinoma (NPC) is a common type of cancer worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with the development of multiple types of human cancer. The present study aimed to identify the potential role of lncRNA colon cancer associated transcript 1 (CCAT1) in NPC. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression levels of CCAT1 in NPC tissues and cell lines. The function of CCAT1 in the proliferation, migration, invasion and apoptosis of NPC cells was detected by MTT, cell scratch, Transwell, flow cytometry and caspase-3 ELISA assays, respectively...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013669/association-between-rectal-bleeding-and-the-absolute-dose-volume-of-the-rectum-following-image-guided-radiotherapy-for-patients-with-prostate-cancer
#6
Kazuki Kotabe, Hidetsugu Nakayama, Aruga Takashi, Atsuko Takahashi, Tsuyoshi Tajima, Haruki Kume
The association between rectal bleeding and the received dose relative to the volume of the rectum is well established in prostate cancer patients who have undergone radiotherapy. The relative volume of the rectum is affected by the rectal anatomical volume, which depends on the definition of rectal length. Compared with the relative rectal volume, the absolute volume of the rectum may be more associated with rectal bleeding. The present study investigated the absolute volume of the rectum that may be used to predict late rectal bleeding following intensity-modulated radiotherapy (IMRT) and image-guided radiotherapy (IGRT)...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013668/the-impact-of-inflammation-and-cytokine-expression-of-pm2-5-in-aml
#7
Tingting Chen, Juan Zhang, Hui Zeng, Yue Zhang, Yong Zhang, Xiaohuan Zhou, Dong Zhao, Yingmei Feng, Hebing Zhou
Environmental and health issues have become a major focus of research worldwide in recent years. Particulate matter with diameter ≤2.5 µm (PM2.5) is a common air pollutant that has been demonstrated to be associated with various diseases, including acute myeloid leukemia (AML). In the present study, the effects of PM2.5 on the proliferation and inflammation were assessed using three human acute myeloid cell lines (U937, HL-60 and KG-1a) in vitro . Additionally, the levels of several cytokines [interleukin (IL)-2, IL-10, IL-17A and tumor necrosis factor (TNF)α] in AML cells and Sprague Dawley rats were evaluated to investigate the effects of PM2...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013667/synergistic-antitumor-activity-of-aspirin-and-erlotinib-inhibition-of-p38-enhanced-aspirin-plus-erlotinib-induced-suppression-of-metastasis-and-promoted-cancer-cell-apoptosis
#8
Xiu Hu, Lin-Wen Wu, Xu Weng, Neng-Ming Lin, Chong Zhang
High-dose erlotinib is effective for non-small cell lung cancer patients with brain metastases. The aim of the present study was to investigate whether aspirin could increase the anti-proliferative and anti-metastatic effects of regular erlotinib treatment. The data demonstrated that combining aspirin with erlotinib significantly induced apoptosis and inhibited tumor cell proliferation in several human cancer types. Furthermore, aspirin plus erlotinib significantly induced the activation of E-cadherin and suppression of p38...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013666/ecotropic-viral-integration-site-1-regulates-the-progression-of-acute-myeloid-leukemia-via-ms4a3-mediated-tgf%C3%AE-emt-signaling-pathway
#9
Min Jiang, Xueqin Zou, Wenhua Huang
Acute myeloid leukemia (AML) is a type of malignant tumor that is caused by malignant clone hematopoietic stem cells. The ecotropic viral integration site 1 (Evi1) is a zinc finger transcription factor, which is highly expressed in AML, and its expression level has been associated with poor prognosis of AML. Previous studies have indicated that Evi1 may regulate cell proliferation, differentiation and apoptosis by inhibiting the membrane-spanning-4-domains subfamily-A member-3 (MS4A3) gene in AML. The aim of the present study was to investigate the role of Evi1 in the progression of AML...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013665/microrna-539-inhibits-colorectal-cancer-progression-by-directly-targeting-sox4
#10
Jian Zhao, Jian Xu, Rui Zhang
Colorectal cancer (CRC) is the third most prevalent cancer and the fourth most common cause of cancer-associated mortality in males and females globally. Aberrant expression of microRNA-539 (miR-539) has been reported in multiple types of cancer. However, miR-539 expression, function and underlying mechanisms have not been clearly elucidated in CRC. In the present study, miR-539 expression was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in CRC tissues and cell lines. The effects of miR-539 on CRC cells were further examined in in vitro studies...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013664/clinicopathological-characteristics-of-malignant-melanomas-of-the-skin-and-gastrointestinal-tract
#11
Michiko Akiyama, Yoko Matsuda, Tomio Arai, Hidehisa Saeki
The present study examined the differences between gastrointestinal melanoma (GM) and skin melanoma (SM). The clinicopathological characteristics, the expression of melanoma stem cell markers nestin, sex determining region Y-box 2 and ATP-binding cassette sub-family B member 5, and the presence of the BRAFV600E mutation were evaluated in 10 cases of GM and 31 cases of SM. Patients with GM had an increased mean age compared with those with SM (76 vs. 68 years). In addition, GMs were significantly more likely than SMs to be amelanotic (50 vs...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013663/effect-of-period-2-on-the-proliferation-apoptosis-and-migration-of-osteosarcoma-cells-and-the-corresponding-mechanisms
#12
Tao Qin, Xiao-Ting Lu, Yong-Gang Li, Yan Liu, Wenjiang Yan, Na Li, Yuan-Yuan Sun
Period 2 (per2) is a core circadian clock gene. Dysregulation of the per2 gene has been identified in a number of types of human cancer and may be associated with a poor prognosis. To confirm the influence of per2 gene on MNNG/HOS human osteosarcoma cells, small interfering (si)RNA against per2 or plasmids containing per2 were transfected into MNNG/HOS cells, and the proliferation, apoptosis and migration were observed. The present study demonstrated that per2 knockdown significantly enhanced MNNG/HOS cell proliferation and migration and protected MNNG/HOS cells from apoptosis...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013662/expression-of-aqp3-and-aqp5-as-a-prognostic-marker-in-triple-negative-breast-cancer
#13
Zhengcai Zhu, Lianghe Jiao, Tao Li, Honggang Wang, Wei Wei, Haixin Qian
Triple-negative breast cancer (TNBC) is a common type of breast malignancy with high a propensity for metastasis and locoregional recurrence. The aim of the present study was to investigate the expression of aquaporin (AQP) 3 and AQP5, analyze their association with clinicopathological parameters and explore their clinical significance in tissue samples from patients with TNBC. Immunohistochemistry was performed to detect the expression patterns of AQP3 and AQP5 in 96 patients with TNBC who underwent surgery between 2007 and 2012...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013661/cell-free-dna-and-chemoembolization-in-patients-with-liver-metastases-from-colorectal-cancer
#14
Anders Kindberg Boysen, Martin Jensen, Dennis Tønner Nielsen, Frank Viborg Mortensen, Brita Singers Sørensen, Anni Ravnsbæk Jensen, Karen-Lise Spindler
Transarterial chemoembolization with irinotecan loaded beads (DEBIRI-TACE) represents an investigative treatment option for patients with metastatic colorectal cancer (mCRC). The present study examined DEBIRI-TACE with concomitant mFOLOFX6-bevacizumab as a first-line treatment for mCRC and explored the clinical value of circulating cell-free DNA (cfDNA). Patients with limited mCRC of the liver who had not been treated with chemotherapy received up to 4 biweekly DEBIRI-TACE treatments. The endpoints examined included the response rate, survival, toxicity and translational analysis...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013660/overexpression-of-rod1-inhibits-invasion-of-breast-cancer-cells-by-suppressing-the-translocation-of-%C3%AE-catenin-into-the-nucleus
#15
Ya Zhou, Hanqing Zou, Enhao Wu, Lei Huang, Rui Yin, Yuxin Mei, Xun Zhu
The incidence of breast cancer is increasing throughout the world. Although significant progress has been made in diagnostic techniques and targeted therapies, the prognosis of breast cancer remains poor. Regulator of differentiation 1 (ROD1) may inhibit the development of several types of cancer. However, the role of ROD1 in breast cancer cells remains unknown. In the present study, western blot analysis and reverse transcription-quantitative polymerase chain reaction revealed that expression of ROD1 was significantly reduced in breast cancer cells...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013659/mirna-29a-inhibits-colon-cancer-growth-by-regulation-of-the-pten-akt-gsk3%C3%AE-and-wnt-%C3%AE-catenin-signaling-pathways
#16
Xiaofeng Han, Jianwei Zheng, Yunlei Wang, Zhigang Gao
In the present study, the effects of microRNA-29a (miRNA-29a) on colon cancer cell viability and the molecular mechanisms underlying the effects were investigated. The expression of miRNA-29a in colon cancer serum samples was notably downregulated, compared with in the normal group. First, miRNA-29a mimic was used to increase the expression of miRNA-29a in HCT-116 cells. Furthermore, upregulation of miRNA-29a suppressed cell viability, increased lactate dehydrogenase levels and apoptosis, and promoted caspase-3/9 activities and B-cell lymphoma 2-associated X protein and phosphatase and tensin homolog (PTEN) protein expression in colon cancer cells...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013658/role-of-the-tumour-protein-p53-gene-in-human-cervical-squamous-carcinoma-cells-discussing-haematopoietic-cell-specific-protein-1-associated-protein-x-1-induced-survival-migration-and-proliferation
#17
Bing Qian, Li-Jun Zhao, Fang Teng, Ling-Juan Gao, Rong Shen
The haematopoietic cell-specific protein 1-associated protein X-1 (HAX-1), as a mitochondrial membrane protein, induces cancer progression and metastasis. The present study aimed to investigate the role of HAX-1-induced survival, migration and proliferation of human cervical squamous carcinoma cells and to elucidate its potential molecular mechanisms. The level of HAX-1 was examined by quantitative polymerase chain reaction and western blot analyses. The survival, migration and proliferation of the human cervical squamous carcinoma SiHa cell line were measured by the water-soluble tetrazolium salt (WST-1) assay, Transwell assay and 3 H-thymidine incorporation into DNA (3 H-TdR) assay, respectively...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013657/mir-214-3p-promotes-the-proliferation-migration-and-invasion-of-osteosarcoma-cells-by-targeting-cadm1
#18
Haiqing Cai, Mingyuan Miao, Zhigang Wang
Although osteosarcoma (OS) is the most common type of primary bone tumor in adolescents and young adults, its mechanism remains unclear. A previous study by the authors demonstrated that miR-214-3p was upregulated in OS patients. Therefore, the present study aimed to investigate the effect and molecular mechanism of miR-214-3p in OS cells. OS cell lines, U2OS and MNNG/HOS Cl#5, were transiently transfected with miR-214-3p mimics, a control mimic, miR-214-3p inhibitors and a control inhibitor. Subsequent assays revealed that elevated miR-214-3p promoted the proliferative, migratory and invasive abilities of OS cells, while the opposite effects were observed in cells that were transfected with miR-214-3p inhibitors...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013656/dihydroartemisinin-suppresses-the-proliferation-of-epstein-barr-virus-associated-gastric-carcinoma-cells-via-downregulation-of-latent-membrane-protein-2a
#19
Wei Gong, Lei Zhang, Hui Yu, Qiang Yu, Wei-Kang Pan, Yin Wang, Xuan-Lin Wu, Qiang Liu
Treatment of recurrent and metastatic Epstein-Barr virus-associated gastric carcinoma (EBVaGC) remains a challenge, particularly in developing countries, due to lack of efficient screening programs. Latent membrane protein 2A (LMP2A) has been reported to serve an important function in the development of EBVaGC. In previous years dihydroartemisinin (DHA), traditionally used as an anti-malarial agent, has been demonstrated to inhibit tumor growth with low toxicity to normal cells. In the present study, the anti-tumor effect of DHA in EBVaGC was investigated...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30013655/-fusobacterium-nucleatum-promotes-the-progression-of-colorectal-cancer-by-interacting-with-e-cadherin
#20
Chun-Ting Ma, He-Sheng Luo, Feng Gao, Qin-Cai Tang, Wei Chen
Increasing evidence suggests that Fusobacterium nucleatum is involved in colorectal carcinogenesis. Previous studies have explored whether F. nucleatum may trigger colonic epithelial-mesenchymal transition. The results of the present study demonstrated that F. nucleatum enhances the proliferation and invasion of NCM460 cells compared with that of normal control and DH5α cells. Furthermore, F. nucleatum significantly increased the phosphorylation of p65 (a subunit of nuclear factor-κB), as well as the expression of interleukin (IL)-6, IL-1β and matrix metalloproteinase (MMP)-13...
August 2018: Oncology Letters
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