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Oncology Letters

Hiromichi Maeda, Ken-Ichi Okada, Tsutomu Fujii, Mari S Oba, Manabu Kawai, Seiko Hirono, Yasuhiro Kodera, Masayuki Sho, Takahiro Akahori, Yasuhiro Shimizu, Yoshiyasu Ambo, Naru Kondo, Yoshiaki Murakami, Jiro Ohuchida, Hidetoshi Eguchi, Hiroaki Nagano, Junichi Sakamoto, Hiroki Yamaue
Our previous study aimed to examine the effect of TJ-100, a widely used herbal medicine, on intestinal function following pancreaticoduodenectomy (PD) in a multicenter, randomized, double-blinded, placebo-controlled manner (JAPAN-PD study). This concomitant study investigated the effect of TJ-100 on serum cytokine levels in patients who underwent PD. Due to the fact that several clinical variables can affect the absolute values of baseline serum cytokine levels, the ratios of the cytokine levels on postoperative day (POD)3 to those on POD1 were also used for analysis...
November 2018: Oncology Letters
Feng Guo, Xinming Hou, Qinghui Sun
MicroRNAs (miRNAs/miRs) are widely studied as key regulators of gene expression and are involved in various diseases by affecting the miRNA-mediated regulatory function. BRAF is an important oncogene in the regulation of cell proliferation and apoptosis. In the present study, reverse transcription-quantitative polymerase chain reaction was used to determine the expression levels of miR-9-5p and BRAF mRNA in patients with papillary thyroid cancer (PTC). Western blotting was used to detect BRAF protein level...
November 2018: Oncology Letters
Zijian Liu, Yuzhu Li, Quanxiang Luo
Our study investigated the relationship between CT signs of colon cancer and the expression of miR-146a, to evaluate their predictive value in early diagnosis and of colon cancer. A total of 216 patients with colon cancer who were admitted to the Department of Hematology and Oncology in Yingcheng Hospital, the Second Hospital of Shandong University in Zhaoyuan City from January 2013 to March 2017 were selected as the study group. At the same time, 150 patients with benign colitis were also included to serve as the control group...
November 2018: Oncology Letters
Chin-Fu Chen, Chi-Cheng Lu, Jo-Hua Chiang, Hong-Yi Chiu, Jai-Sing Yang, Chao-Ying Lee, Tzong-Der Way, Hao-Jen Huang
Cetuximab, an epidermal growth factor receptor (EGFR)-targeting monoclonal antibody (mAb), is a novel targeted therapy for the treatment of patients with oral cancer. Cetuximab can be used in combination with chemotherapeutic agents to prolong the overall survival rates of patients with oral cancer. Curcumin is a traditional Chinese medicine, and it has been demonstrated to have growth-inhibiting effects on oral cancer cells. However, information regarding the combination of cetuximab and curcumin in drug-resistant oral cancer cells is lacking, and its underlying mechanism remains unclear...
November 2018: Oncology Letters
Lu Zhong, Fei Xu, Fangyuan Chen
Lymphoma is a type of cancer that develops from certain immune system cells. Arsenic trioxide (ATO) has attracted wide attention owing to its antitumor activities. However, the role of ATO in tumorigenesis and progression remains to be investigated. In the present study, the antitumor function of ATO was investigated in in lymphoma Raji and Jurkat cell lines and the effect of ATO on nuclear factor (NF)-κB expression levels. A Cell Counting kit-8 assay was used to assess cellular proliferation and the degree of cell apoptosis was measured by flow cytometric analysis; these assays demonstrated that ATO inhibited proliferation and promoted the apoptosis of Raji and Jurkat cells in a dose- and time-dependent manner...
November 2018: Oncology Letters
Xiaowei Xie, Wei Zhao, Jinglin Pang, Xiaomiao Xiong, Haiyan Wang, Lingyun Ma
Research has demonstrated that long non-coding RNAs (lncRNAs) are crucial factors in carcinogenesis. LncRNA, cardiac hypertrophy-related factor (CHRF), has been demonstrated to act as an oncogene in a variety of types of tumor. However, its biological function in lung adenocarcinoma remains to be elucidated. The present study aimed to examine the level of CHRF expression in lung adenocarcinoma tissues and cell lines, and to analyze the association between CHRF and clinicopathological characteristics, as well prognosis of patients with lung adenocarcinoma...
November 2018: Oncology Letters
Franziska Brandi, Katharina Grupp, Claudia Hube-Magg, Martina Kluth, Dagmar Lang, Sarah Minner, Christina Möller-Koop, Markus Graefen, Hans Heinzer, Maria Christina Tsourlakis, Corinna Wittmer, Frank Jacobsen, Hartwig Huland, Stefan Steurer, Patrick Lebok, Andrea Hinsch, Waldemar Wilczak, Thorsten Schlomm, Ronald Simon
Approximately 50% of prostate cancer types harbor the transmembrane protease, serine 2: Erythroblast transformation-specific-related gene (ERG) fusion, resulting in oncogenic expression of the ERG transcription factor. ERG represents an attractive target for potential future anticancer therapy in advanced and metastatic prostate cancer. To better understand whether the analysis of the primary cancer is sufficient to estimate the ERG expression status of the lymph node metastases, the present study examined patterns of immunohistochemical ERG expression in a tissue microarray created from multiple primary and metastatic sites of 77 prostate cancer tissues...
November 2018: Oncology Letters
Tetsuya Minegaki, Ai Suzuki, Misato Mori, Shiori Tsuji, Satoshi Yamamoto, Airi Watanabe, Tomoyo Tsuzuki, Takaki Tsunoda, Asuka Yamamoto, Masayuki Tsujimoto, Kohshi Nishiguchi
Resistance to 5-fluorouracil (5-FU) is a serious problem in cancer therapy and overcoming it is required in order to improve the efficacy of cancer chemotherapy. Histone deacetylase (HDAC) inhibitors are used in cancer treatments and, recently, it has been reported that HDAC inhibitors can overcome resistance to various anti-cancer drugs in vitro . In the present study, a 5-FU-resistant breast cancer cell line was established, and the effects of HDAC inhibitors in these cells were examined. The 5-FU-resistant cell line MDA-MB-468 (MDA468/FU) was established by continuous exposure of the parental cells to 5-FU...
November 2018: Oncology Letters
Agapiti Hipoliti Chuwa, Kenbun Sone, Katsutoshi Oda, Michihiro Tanikawa, Asako Kukita, Machiko Kojima, Shinya Oki, Tomohiko Fukuda, Makoto Takeuchi, Aki Miyasaka, Tomoko Kashiyama, Yuji Ikeda, Kazunori Nagasaka, Mayuyo Mori-Uchino, Yoko Matsumoto, Osamu Wada-Hiraike, Hiroyuki Kuramoto, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii
Endometrioid endometrial carcinoma, commonly known as type 1 endometrial cancer, accounts for >80% of endometrial carcinomas and is dependent on estrogen. We recently reported on the prognostic significance of the BIRC5 survivin gene in endometrial cancer. Estradiol induces survivin expression in estrogen receptor-positive, but not in estrogen receptor-negative, cancer cells. Kaempferol, a bioflavonoid, reportedly inhibits estrogen receptor-α (ERα) in hormone receptor-positive breast cancer cells. However, whether kaempferol-mediated inhibition of ERα suppresses survivin and induces cell death in endometrial cancer remains unclarified...
November 2018: Oncology Letters
Wen-Hui Weng, Wai-Hung Leung, Yeu Jye Pang, Li-Wei Kuo, Hsi-Hsien Hsu
It is known that colorectal cancer (CRC) cells containing mutations of the genes KRAS and BRAF are predominate mechanisms causing resistance to epidermal growth factor receptor (EGFR) inhibitors, and commonly exhibit a lower expression of microRNA-378 (miR-378) when compared with the wild type. In the present study, the aim was to determine the possible mechanism which associates miR-378 with the mitogen-activated protein kinase pathway, and to determine the efficiency of eicosapentaenoic acid ethyl ester (EPA) in its ability to restore sensitivity towards cetuximab, an EGFR inhibitor...
November 2018: Oncology Letters
Shujing Li, Jianping Zhou, Yu Wang, Keqin Zhang, Junjie Yang, Xinling Zhang, Chunmei Wang, Hongbo Ma, Ji Zhou, Ellen He, Sven Skog
The aim of the present was to assess whether serum thymidine kinase 1 (STK1) concentration is a useful biomarker for the screening of benign prostatic hyperplasia (BPH) or prostate malignancy. Serum samples were collected from 123 patients with prostate carcinoma prior to surgery, biopsy or androgen deprivation therapy and at 3, 6 and 10 months following the procedure. A total of 205 patients with BPH and 266 healthy controls were also utilized. STK1 concentration and total prostate-specific antigen (PSA) were measured in patient serum by use of commercial assays...
November 2018: Oncology Letters
Wen-Zhou Ding, Guo-Yong Han, Hui-Han Jin, Chuan-Fei Zhan, Yuan Ji, Xin-Li Huang
Interleukin (IL)-20 is a member of the IL-10 family of cytokines, which has been reported to participate in autoimmune inflammatory diseases. However, the potential role of IL-20 in hepatocellular carcinoma (HCC) progression has not yet been investigated. In the present study, it was observed that IL-20 mRNA and protein levels were markedly increased in the HCC tissues examined via reverse transcription-quantitative polymerase chain reaction and immunohistochemical staining. In addition, IL-20 expression was significantly associated with tumor size, metastasis, TNM stage and poor prognosis in patients with HCC...
November 2018: Oncology Letters
Hang Yang, Ye Cao, Zhi-Ming Li, Ya-Jun Li, Wen-Qi Jiang, Yan-Xia Shi
Cyclin-dependent kinase inhibitor 2A (p16INK4a ) protein is a surrogate immunohistochemical marker of human papillomavirus infection in oropharynx squamous cell carcinoma (OPSCC). However, the effects of p16INK4a in non-OPSCC require additional analysis. In addition, major gaps remain in the literature, including small volumes of data for China. Therefore, the present study evaluated the frequency of p16INK4a positivity in patients with non-OPSCC in Southern China, and assessed its prognostic value. p16INK4a expression status in patients with non-OPSCC was determined by immunohistochemistry...
November 2018: Oncology Letters
Chuang Tian, Yong Jin, Songshan Shi
Long non-coding RNAs (lncRNAs) have been suggested to serve important roles in the development of a number of human cancer types. An increasing amount of data has indicated that the lncRNA small ubiquitin-like modifier 1 (SUMO1) pseudogene 3 (SUMO1P3) has been involved in various types of human cancer. However, the function SUMO1P3 in the development of pancreatic cancer remains unclear. Firstly, reverse transcription-quantitative polymerase chain reaction was performed to determine the expression of SUMO1P3 in pancreatic cancer tissues and cell lines...
November 2018: Oncology Letters
Jiacui Zhang, Keping Jiao, Jing Liu, Yu Xia
The nuclear factor, erythroid 2 like 2 (Nrf2)/antioxidant response element (ARE) pathway has an important role in the drug resistance of adenocarcinoma, and may act via different mechanisms, including the mitogen-activated protein kinase (MAPK) pathway. However, it has remained elusive whether metformin affects Nrf2 and regulates Nrf2/ARE in adenocarcinoma. In the present study, reverse-transcription quantitative polymerase chain reaction, cell transfection, western blot analysis, a Cell Counting kit-8 assay and apoptosis detection were used to investigate the above in the A549 cell line and cisplatin-resistant A549 cells (A549/DDP)...
November 2018: Oncology Letters
Yang Wang, Chunhui Zheng, Teng Li, Rui Zhang, Yang Wang, Jiaxin Zhang, Qingsi He, Zuocheng Sun, Xinsheng Wang
Gastric cancer is one of the leading causes of cancer-associated mortality and has a high tendency to metastasize, making it a priority to develop novel diagnostic and treatment methods at the early stages. The present study investigated the role of a newly-discovered long non-coding RNA, Z38, in gastric cancer cell proliferation, metastasis and apoptosis. It was observed that Z38 was upregulated in tissues from patients with gastric cancer as well as in cultured gastric cancer cells. Knockdown of Z38 decreased the cell proliferative rate, as evidenced by colony formation assays and cell proliferation assays...
November 2018: Oncology Letters
Nannan Guo, Yingnan Zhao, Wen Zhang, Shaojun Li, Shanshan Li, Jianqi Yu
MicroRNAs (miRNAs) may serve important roles in the regulation of human non-small cell lung cancer (NSCLC) cell growth and apoptosis. To the best of our knowledge, the present study was the first to explore the role of miRNA-133a/epidermal growth factor receptor (EGFR) in regulating NSCLC cell growth and apoptosis via the AKT/extracellular signal-regulated kinase (ERK) signaling pathway. It was determined that miRNA-133a expression was lower in NSCLC tissue than in the adjacent mucosae. Additionally, EGFR expression in the NSCLC tissue was higher compared with in the adjacent mucosae...
November 2018: Oncology Letters
Xin Zhang, Ping Fang, Zigang Zhao, Xiangyu Ding, Fang Xie, Yilin Wang, Chengxin Li
Melanoma is highly malignant, particularly prone to metastasizing to the skin. The incidence of melanoma varies markedly between countries, and is relatively low in China. The aim of the present study was to investigate the antitumorigenic effect of damnacanthal on melanoma cells, and its molecular mechanism. MUM-2B cells were treated with 0-20 µM damnacanthal for 12, 24 and 48 h. In vitro , it was demonstrated that damnacanthal inhibited proliferation and promoted apoptosis of melanoma cells in a dose- and time-dependent manner...
November 2018: Oncology Letters
Xiaodong Tan, Lei Zhou, Huaitao Wang, Yifan Yang, Yang Sun, Zhaoping Wang, Xiaobo Zhang, Feng Gao, Hansi Li
Pancreatic cancer is the eighth-leading cause of cancer-associated mortality worldwide. To date, the cellular and molecular mechanisms associated with the invasion and metastasis of pancreatic cancer remain unclear. To examine these mechanisms, a microRNA (miRNA/miR) microarray with 1,965 genes was hybridized with labeled miRNA probes from invasive PC-1.0 and non-invasive PC-1 cells for molecular profiling analysis. In addition, reverse transcription quantitative-polymerase chain reaction (RT-qPCR) was utilized to validate the microarray results...
November 2018: Oncology Letters
Bo Cai, Limin Ma, Shaojun Nong, You Wu, Xin Guo, Jinxian Pu
Human bladder cancer is one of the most aggressive tumours known and has shown resistance to traditional chemotherapy, which depends heavily on DNA-damaging drugs. β-elemene is one of the least cytotoxic antitumor agents that are extracted from Curcuma aromatica salisb and it exhibits antitumor effects in many carcinomas. β-elemene has attracted the attention of clinicians and scientists worldwide due to its few side effects and limited effect on the bone marrow. However, the antitumor mechanism of β-elemene remains largely unstudied...
November 2018: Oncology Letters
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