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Oncology Letters

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https://www.readbyqxmd.com/read/28693295/germline-dna-copy-number-variations-as-potential-prognostic-markers-for-non-muscle-invasive-bladder-cancer-progression
#1
Yoshiaki Yamamoto, Yutaka Suehiro, Atomu Suzuki, Ryosuke Nawata, Yoshihisa Kawai, Ryo Inoue, Hiroshi Hirata, Hiroaki Matsumoto, Takahiro Yamasaki, Kohsuke Sasaki, Hideyasu Matsuyama
Accumulating evidence has suggested that germline DNA copy number variations (CNVs) affect various disorders, including human malignancies. However, the significance of CNVs in non-muscle invasive bladder cancer (NMIBC) remains unclear. The purpose of the present study was to identify the role of CNVs in NMIBC. Array comparative genomic hybridization (CGH) analysis was performed to search for candidate CNVs associated with NMIBC susceptibility. Quantitative polymerase chain reaction was carried out to evaluate CNVs associated with patient outcome in 189 NMIBC cases...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693294/upregulated-expression-of-mmp-9-in-gingival-epithelial-cells-induced-by-prolonged-stimulation-with-arecoline
#2
Osamu Uehara, Kousuke Takimoto, Tetsuro Morikawa, Fumiya Harada, Rie Takai, Bhoj Raj Adhikari, Ryoko Itatsu, Tomohisa Nakamura, Koki Yoshida, Hirofumi Matsuoka, Hiroki Nagayasu, Ichiro Saito, Malsantha Muthumala, Itsuo Chiba, Yoshihiro Abiko
Betel quid chewing is implicated in the high prevalence of oral cancer in Southeast Asian countries. One of the major components of betel quid is arecoline. In the present study, in order to characterize the association between chronic arecoline stimulation and carcinogenesis the expression level of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 mRNA in human gingival epithelial progenitor cells (HGEPs) stimulated with arecoline was assessed. The HGEPs were alternated between 3 days of incubation with arecoline (50 µg/ml), and 3 days without arecoline, for up to 30 days...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693293/mapk-inhibitors-enhance-cell-death-in-pyrogallol-treated-human-pulmonary-fibroblast-cells-via-increasing-o2-%C3%A2-levels
#3
Bo Ram Han, Woo Hyun Park
Pyrogallol (PG) induces apoptosis in lung cancer cells via the overproduction of O2(•-) and affects mitogen-activated protein kinases (MAPKs) in these cells. The aim of the present study was to elucidate the effect of PG and/or MAPK inhibitors on human pulmonary fibroblast (HPF) cell viability in relation to reactive oxygen species (ROS) and glutathione (GSH). Treatment with 50 or 100 µM PG inhibited the viability of HPF cells, and induced cell death and the loss of mitochondrial membrane potential (MMP; ΔΨm)...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693292/computed-tomography-and-magnetic-resonance-imaging-features-of-ovarian-fibrothecoma
#4
Jingya Chen, Jianhua Wang, Xiao Chen, Yaohui Wang, Zhongqiu Wang, Dake Li
The aim of the present study was to investigate the imaging characteristics of ovarian fibrothecoma. The cases of 25 female patients with pathologically confirmed ovarian fibrothecomas were retrospectively reviewed. Tumor location, size, density, signal intensity, cystic degeneration, calcification, enhancement pattern and ascites were assessed by computed tomography (CT) (n=20) and magnetic resonance imaging (MRI) (n=5). Clinical and histological features were also evaluated. The results revealed that 23 (92...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693291/diagnostic-clue-of-nodular-fasciitis-mimicking-metastasis-in-papillary-thyroid-cancer-mismatching-findings-on-18-f-fdg-pet-ct-and-123-i-whole-body-scan-a-case-report
#5
Minjung Seo, Misung Kim, Eun Sook Kim, Hongbo Sim, Sungmin Jun, Seol Hoon Park
This study reports a case of nodular fasciitis incidentally detected in a patient with papillary thyroid cancer. A 47-year-old woman underwent a total thyroidectomy and radioactive iodine therapy for papillary thyroid cancer. On a follow-up fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) scan after 12 months, a focal (18)F-FDG-avid lesion was incidentally detected in the paraspinal muscle. It was well-enhanced on CT and magnetic resonance imaging, indicating metastasis. However, the lesion was not iodine avid on the (123)I whole body scan, which favored benign etiology over metastasis from thyroid cancer...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693290/therapy-with-transcutaneous-administration-of-imiquimod-combined-with-oral-administration-of-sorafenib-suppresses-renal-cell-carcinoma-growing-in-an-orthotopic-mouse-model
#6
Takashi Karashima, Keiko Udaka, Mayumi Niimura, Katsuhide Suzuki, Hiroto Osakabe, Tsutomu Shimamoto, Satoshi Fukata, Keiji Inoue, Naoto Kuroda, Motoharu Seiki, Taro Shuin
Imiquimod is an imidazoquinoline immune response modifier that is used in antiviral and antiallergic creams. Combination therapy using transcutaneous imiquimod and oral sorafenib was previously demonstrated to reduce the tumor burden of renal cell carcinoma growing cutaneously in a mouse model. In the present study, an orthotopic mouse model was used to investigate whether combined treatment with oral sorafenib and transcutaneous imiquimod inhibited renal cell carcinoma growing in the kidney. Kidneys of female BALB/c mice were orthotopically implanted with RENCA mouse kidney cancer cells, and the mice were transcutaneously treated with cream containing imiquimod and/or with orally administered sorafenib 5 days following cell implantation...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693289/antitumor-effects-of-curcumin-in-human-bladder-cancer-in-vitro
#7
Jing Shi, Xu Zhang, Taoping Shi, Hongzhao Li
Bladder cancer is one of the major causes of cancer-associated mortality, with a high incidence. Curcumin, a polyphenol compound extracted from turmeric, has been identified to regulate tumor progression. However, the therapeutic effect of curcumin in human bladder cancer has not yet been determined. In the present study, the effects of curcumin on cell growth, apoptosis and migration of bladder cancer cell lines were evaluated using an MTT assay, a Transwell assay and flow cytometry, and the associated mechanisms were investigated using western blot analysis...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693288/epigallocatechin-3-gallate-inhibits-growth-and-induces-apoptosis-in-esophageal-cancer-cells-through-the-demethylation-and-reactivation-of-the-p16-gene
#8
Jianchao Meng, Qiang Tong, Xiaobo Liu, Zongtao Yu, Jicai Zhang, Bo Gao
The present study aimed to investigate the effect of treatment with epigallocatechin-3-gallate (EGCG) on the human esophageal cancer cell line ECa109 and elucidate the associated underlying mechanisms. ECa109 cells were cultured and treated with increasing concentrations of EGCG for various durations. Cell viability was evaluated using the MTT assay and apoptosis was detected using flow cytometry. The methylation status of the cyclin-dependent kinase inhibitor 2A (p16) gene was analyzed using the methylation-specific polymerase chain reaction (PCR)...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693287/effect-of-thymoquinone-on-head-and-neck-squamous-cell-carcinoma-cells-in-vitro-synergism-with-radiation
#9
Ulana Kotowski, Gregor Heiduschka, Lorenz Kadletz, Tammer Fahim, Rudolf Seemann, Rainer Schmid, Sven Schneider, Andreas Mitterbauer, Dietmar Thurnher
Thymoquinone (TQ) is the main bioactive constituent present in black seed oil (Nigella sativa); it has shown anti-inflammatory and anti-neoplastic effects in various cancer cell types. The aim of the present study was to investigate the effects of TQ on head and neck squamous cell carcinoma (HNSCC) cell lines, on its own and in combination with radiation and cisplatin, respectively. The SCC25 and CAL27 HNSCC cell lines were treated with TQ alone and in combination with cisplatin or radiation, respectively. Proliferation assays and clonogenic assays were performed...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693286/bevacizumab-as-a-last-line-treatment-for-glioblastoma-following-failure-of-radiotherapy-temozolomide-and-lomustine
#10
Katharina J Wenger, Marlies Wagner, Se-Jong You, Kea Franz, Patrick N Harter, Michael C Burger, Martin Voss, Michael W Ronellenfitsch, Emmanouil Fokas, Joachim P Steinbach, Oliver Bähr
In previous trials, bevacizumab failed to prolong the overall survival time in newly diagnosed glioblastoma and at the first recurrence. Randomized clinical trials at the second or further recurrence following the failure of radiotherapy, temozolomide and lomustine, and retrospective analyses focusing on this specific cohort, are not yet available. A total of 62 patients with glioblastoma who received bevacizumab after the failure of standard care, including radiotherapy, temozolomide and lomustine, were retrospectively identified...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693285/characterization-of-%C3%AE-%C3%AE-t-cells-in-patients-with-non-small-cell-lung-cancer
#11
Yi Bao, Li Guo, Juanfen Mo
Systemic immune defects that are associated with disease progression exist in a variety of malignancies. γδ T cells are innate-like lymphocytes that do not require self-major histocompatibility complex-restricted priming. Ex vivo-expanded circulating γδ T cells exhibit promising antitumor activity and are a potential candidate for the treatment of various malignancies, including non-small cell lung cancer (NSCLC). In the present study, flow cytometry was used as a method to study the phenotypes and characteristics of γδ T cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693284/%C3%AE-human-chorionic-gonadotropin-secreting-intracranial-germ-cell-tumor-associated-with-high-testosterone-in-an-adult-man-a-case-report
#12
Wen-Ping Yang, Hung-Yu Chien, Yi-Chun Lin
A 38-year-old male patient presented with general weakness, polydipsia and a body weight loss of 10 kg in two years. Hypopituitarism with central hypothyroidism and central adrenal insufficiency were noted at Taipei City Hospital (Taipei, Taiwan). However, hypogonadotropic hypergonadism was also observed. The patient was diagnosed with an intracranial β-human chorionic gonadotropin (β-hCG) secreting germ-cell tumor, and brain magnetic resonance imaging revealed that the tumor involved the pineal gland, stalk, posterior pituitary gland, right basal ganglion, hypothalamus, corpus callosum and posterior hippocampus...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693283/prospective-exploratory-study-of-gemcitabine-and-s-1-against-elderly-patients-with-advanced-non-small-cell-lung-cancer
#13
Kyoichi Kaira, Noriko Yanagitani, Noriaki Sunaga, Hisao Imai, Akihiro Ono, Yasuhiko Koga, Takeshi Hisada, Tamotsu Ishizuka, Masanobu Yamada
A prospective study was conducted to investigate the efficacy of a combined regimen of gemcitabine and S-1 for the treatment of elderly patients (>70 years) with advanced non-small cell lung cancer (NSCLC) as a first-line setting based on the dosage recommended in a previous phase I study. Chemotherapy-naïve patients with advanced NSCLC received gemcitabine plus S-1. S-1 (40 mg/m(2)) was administered orally twice daily for 14 days while gemcitabine (1,000 mg/m(2)) was administered on days 1 and 15 of each cycle, and this regimen was repeated every 4 weeks...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693282/identification-of-hub-genes-and-pathways-associated-with-bladder-cancer-based-on-co-expression-network-analysis
#14
Dong-Qing Zhang, Chang-Kuo Zhou, Shou-Zhen Chen, Yue Yang, Ben-Kang Shi
The aim of the present study was to identify hub genes and signaling pathways associated with bladder cancer (BC) utilizing centrality analysis and pathway enrichment analysis. The differentially expressed genes (DEGs) were screened from the ArrayExpress database between normal subjects and BC patients. Co-expression networks of BC were constructed using differentially co-expressed genes and links, and hub genes were investigated by degree centrality analysis of co-expression networks in BC. The enriched signaling pathways were investigated by Kyoto Encyclopedia of Genes and Genomes database analysis based on the DEGs...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693281/coffee-reduces-kras-expression-in-caco-2-human-colon-carcinoma-cells-via-regulation-of-mirnas
#15
Takuya Nakayama, Megumi Funakoshi-Tago, Hiroomi Tamura
Previous epidemiological studies have demonstrated that moderate coffee consumption is associated with a lower risk of certain types of cancer, particularly colon cancer. To elucidate the molecular basis for this protective action, the effect of coffee on Caco-2 human colon carcinoma cells was investigated. Low concentrations of coffee (<5%) inhibited proliferation of Caco-2 cells without affecting cell viability. Coffee also reduced KRAS proto-oncogene, GTPase (KRAS) gene expression in a dose-dependent manner; however, caffeine, caffeic acid and chlorogenic acid, three major constituents of coffee, did not exhibit this effect...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693280/improved-antitumor-effect-of-ionizing-radiation-in-combination-with-rapamycin-for-treating-nasopharyngeal-carcinoma
#16
Di Wang, Lichen Gao, Xueting Liu, Chuang Yuan, Guihua Wang
The aim of the present study is to investigate if rapamycin is a radiosensitizer of nasopharyngeal carcinoma (NPC), and to identify which pathways are involved in radiation sensitization. In vitro, using untreated cells as the control, NPC cells were treated with rapamycin, ionizing radiation (IR) or both. Differences in the phosphorylation of ribosomal protein S6 and glycogen synthase kinase (GSK) 3β, expression of cyclin D1, clonogenic survival, number of phosphorylated histone subunit 2AX (γH2AX) foci, and cell cycle status between the study groups were compared...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693279/microrna-215-acts-as-a-tumor-suppressor-in-breast-cancer-by-targeting-akt-serine-threonine-kinase-1
#17
Jian Yao, Ping Zhang, Jin Li, Wei Xu
There are accumulating reports that microRNAs are dysregulated in a number of human cancer types, and that they may function as tumor suppressors or oncogenes in tumorigenesis and tumor development. microRNA-215 (miR-215) has been identified as a tumor suppressor in epithelial ovarian, pancreatic, non-small cell lung and colon cancer, whereas it may act as an oncogene in gastric and cervical cancer. The role of miR-215 in breast cancer carcinogenesis and progression has yet to be elucidated. In the present study, the expression level of miR-215 was determined in breast cancer tissues and cell lines using the reverse transcription-quantitative polymerase chain reaction...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693278/sunitinib-does-not-impair-natural-killer-cell-function-in-patients-with-renal-cell-carcinoma
#18
Jennifer Moeckel, Nina Staiger, Andreas Mackensen, Norbert Meidenbauer, Evelyn Ullrich
Although the available treatment options have expanded, the survival of patients with metastatic renal cell carcinoma (RCC) remains poor. As patients with RCC lack responsiveness to chemotherapy or radiation, therapeutic options predominantly include surgical interventions and immunomodulatory approaches, including the administration of tyrosine kinase inhibitors (TKIs) such as sunitinib. Natural killer (NK) cells have been reported to be key players in TKI-mediated off-target effects on the immune system. However, only limited information is available regarding the possible impact of sunitinib on the function of NK cells of individual patients...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693277/curcumol-triggers-apoptosis-of-p53-mutant-triple-negative-human-breast-cancer-mda-mb-231-cells-via-activation-of-p73-and-puma
#19
Lanzhen Huang, Ang Li, Guanzhen Liao, Feicheng Yang, Jing Yang, Xu Chen, Xiaoshan Jiang
Triple-negative breast cancer (TNBC; estrogen receptor-negative, progesterone receptor-negative and Her-2-negative) is often accompanied by a higher frequency of p53 gene mutations. Therefore, TNBC is challenging to treat due to a lack of biological targets and a poor sensitivity to conventional therapies. Curcumol is a monomer composition isolated from the ethanol extracts of Curcuma wenyujin, a Chinese medicinal herb traditionally used as a cancer remedy. Previous studies have revealed that curcumol is able to block proliferation in various human tumor cell lines...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693276/examination-of-the-predictive-factors-of-the-response-to-whole-brain-radiotherapy-for-brain-metastases-from-lung-cancer-using-mri
#20
Shuri Aoki, Tomonori Kanda, Noriyuki Matsutani, Nobuhiko Seki, Masafumi Kawamura, Shigeru Furui, Hideomi Yamashita
Previous studies have been conducted on the prognostic factors for overall survival in patients with brain metastases (BMs) following whole brain radiotherapy (WBRT). However, there have been a small number of studies regarding the prognostic factors for the response of tumor to WBRT. The aim of the present study was to identify the predictive factors for the response to WBRT from the point of view of reduction of tumor using magnetic resonance imaging. A retrospective analysis of 62 patients with BMs from primary lung cancer treated with WBRT was undertaken...
July 2017: Oncology Letters
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