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Oncology Letters

Ya-Xuan Liu, Ke-Jing Zhang, Li-Li Tang
Androgen receptor (AR) is closely associated with the occurrence and progression of breast cancer; however, the clinical significance of it in triple negative breast cancer (TNBC) has been controversial. There is a limited amount of research regarding the effect of neoadjuvant chemotherapy on AR expression. By examining the expression of AR in patients with TNBC, the aim of the present study is to explore the clinical significance of AR and provide evidence for AR-directed treatment in TNBC. A total of 188 patients with primary TNBC with complete medical records were included in this retrospective study...
June 2018: Oncology Letters
Bin Zhao, Ruiqian Li, Gang Cheng, Zhiyao Li, Zhiping Zhang, Jun Li, Guoying Zhang, Chengwei Bi, Chen Hu, Libo Yang, Yonghong Lei, Qilin Wang
The present study aimed to understand the roles of hepcidin and iron metabolism in the onset of prostate cancer. The prostate cancer LNCap, PC3 and DU145 cell lines were transfected with small interfering RNA (siRNA) targeting hepcidin to knockdown hepcidin expression in LNCap, PC3 and DU145 cells. The expression levels of hepcidin in prostate cancer and normal prostate RWPE-1cells were detected by western blot analysis. Exogenous hepcidin was added into the hepcidin-silenced cell lines. Intracellular iron levels were detected using a fluorescence assay, and the proliferative and migratory capacities of cells were detected using the MTT and wound-healing assays, respectively...
June 2018: Oncology Letters
Shengquan Fang, Min Gao, Shilu Xiong, Qian Chen, Huifeng Zhang
The aim of the study was to investigate the differential expression of micro-ribonucleic acid (miRNA)-93 in serum of patients with uterine cancer, and to explore the clinical significance. A total of 176 patients with uterine cancer who received surgery from May, 2009 to January, 2011 in the Department of Oncology of Hubei Cancer Hospital were selected. At the same time, 100 healthy individuals selected from the Physical Examination Center of Hubei Cancer Hospital comprised the control group. Mean age of patients was 55±11 years, and of the healthy individuals in the control group was 53±9 years...
June 2018: Oncology Letters
Min-Hsi Lin, You-Zuo Chen, Mei-Yu Lee, Ken-Pen Weng, Hong-Tai Chang, Shou-Yu Yu, Bo-Jhu Dong, Fan-Rong Kuo, Li-Tzu Hung, Li-Feng Liu, Wei-Shone Chen, Kuo-Wang Tsai
MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation of tumor suppressors and oncogenes during lung cancer progression. Selection of the 5p and 3p arms of miRNA is a mechanism that improves the modulation of miRNA biological functions and complicates the regulatory network in human types of cancer. However, the involvement of arm selection preference of miRNA in lung cancer remains unclear. In the present study, changes in miRNA arm selection preference were comprehensively identified in lung cancer and corresponding adjacent normal tissues by analyzing The Cancer Genome Atlas...
June 2018: Oncology Letters
Xue Wu, Fei Wang, Yuan Li, Xiyong Wang, Ping Liu, Haijun Zhang, Zheng Ge, Xiaoping Zhang, Chong Gao, Baoan Chen
Diffuse large B cell lymphoma (DLBCL) has previously been demonstrated to contribute to the mortality of lymphoma with various aggressive features. The prognostic role of the biomarkers latent membrane protein (LMP) 1 and microRNA-(miR)-155 in DLBCL remain controversial. The present study primarily aimed to assess the effect of LMP1 and miR-155 on the survival of DLBCL patients, and additionally evaluate the clinical features to observe their influence on outcomes, compared with previous studies. Formalin-fixed and paraffin-embedded samples were collected from our center between May 2010 and December 2011...
June 2018: Oncology Letters
Shouyong Li, Yanlei Wei
The expression of high mobility group box 1 ( HMGB 1), breast cancer susceptibility gene 1 ( BRCA 1) and P62 in ovarian cancer was investigated to explore its association with chemotherapy sensitivity in ovarian cancer patients. Tumor tissues and para-carcinoma normal tissues of 60 ovarian cancer patients hospitalized in Department of Surgery in Dongying Hospital from June, 2012 to June, 2015 were collected. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the mRNA expression levels of HMGB1, BRCA1 and P62 in tumor and para-carcinoma normal tissues...
June 2018: Oncology Letters
Yi Zheng, Fan Yang, Ling Fu, Kang Liu
Primary hepatic carcinoma is a common malignant tumor with poor treatment efficacy. The effect and mechanism of miR-143 in apoptosis of liver carcinoma cells were investigated in the present study. In vitro transfection of liver carcinoma SMMC-7721 cells was performed using artificially synthesized miR-143 mimics. The proliferation of liver carcinoma cells that were treated was detected by MTT assay. Liver carcinoma cells were then stained using the Annexin V-FITC/PI method, and the apoptosis of stained liver carcinoma cells was measured using a flow cytometer...
June 2018: Oncology Letters
Changqing Shao, Cuiling Zheng, Wanshu Yan, Yi Shen, Zhixue Zhang
The aim of the study was to investigate the efficacy and safety of minimally invasive segmentectomy in the treatment of lung cancer. A total of 86 lung cancer patients in early stage were selected for the treatment between May, 2010 and December, 2010. The patients were randomly divided into the control (n=43) and observation (n=43) groups. Patients in the control group received conventional thoracotomy as treatment, while thoracoscopic segmentectomy was performed for patients in the observation group. Factors including intraoperative bleeding amount, number of dissected lymph nodes, surgery duration, postoperative intubation time and length of stay (LOS) were compared between the two groups...
June 2018: Oncology Letters
Liangliang Wu, Hongyu Liu, Hongchuan Guo, Qiong Wu, Songyan Yu, Yuanyuan Qin, Gang Wang, Qiyan Wu, Rong Zhang, Lingxiong Wang, Lijun Zhang, Chunxi Liu, Shunchang Jiao, Tianyi Liu
Myeloid-derived suppressor cells (MDSCs) serve an immunosuppressive role in human tumors. Human Lin-/low human leukocyte antigen-antigen D related (HLA-DR- ) cluster of differentiation (CD)-11b+ CD33+ MDSCs are closely linked with tumor staging, progression, clinical therapeutic efficacy and prognosis for various types of tumors. The present study employed multiparametric flow cytometry to measure the proportion of Lin-/low HLA-DR- CD11b+ CD33+ MDSCs in the peripheral blood of 105 cervical cancer patients and 50 healthy subjects...
June 2018: Oncology Letters
Yao Yang, Jianfeng Shen, Dongyi Yan, Biao Yuan, Shun Zhang, Jing Wei, Tao Du
Gastric cancer (GC) is among the most aggressive types of cancer and is the second leading cause of cancer-associated mortality worldwide. The specific role of deregulated expression/activity of histone methyltransferases (HMTs) in GC is poorly understood. The present study aimed to explore the possible oncogenic role of euchromatic histone lysine methyltransferase 1 (EHMT1) in gastric carcinogenesis. It was identified that EHMT1 was highly expressed in GC tissues compared with that in adjacent non-tumor tissues, and that EHMT1 expression levels were significantly associated with tumor stage and lymph node metastasis...
June 2018: Oncology Letters
Xiaoqing Wang, Lili Xiao, Haitao Yu
As a type of malignant tumor developed at the pancreas, the prognosis of pancreatic carcinoma is usually poor, and >90% patients will sucumb to this disease <5 years after diagnosis. Therefore, early detection and treatment of this disease are important for improving the prognosis of patients. Long non-coding RNAs (lncRNAs) have been proven to serve pivotal functions in the development and progression of various tumors. The lncRNA HOXA distal transcript antisense RNA (HOTTIP), which serves an oncogenic role in different types of malignant tumors, has also been reported to be closely correlated with the migration and invasion of pancreatic carcinoma...
June 2018: Oncology Letters
Li Yu, Bo Yin, Kaiying Qu, Jingjing Li, Qiao Jin, Ling Liu, Chunlan Liu, Yuxing Zhu, Qi Wang, Xiaowei Peng, Jianda Zhou, Peiguo Cao, Ke Cao
In the present study, hereditary non-polyposis colorectal cancer (HNPCC) susceptibility genes were screened for using whole exome sequencing in 3 HNPCC patients from 1 family and using single nucleotide polymorphism (SNP) genotyping assays in 96 other colorectal cancer and control samples. Peripheral blood was obtained from 3 HNPCC patients from 1 family; the proband and the proband's brother and cousin. High-throughput sequencing was performed using whole exome capture technology. Sequences were aligned against the HAPMAP, dbSNP130 and 1,000 Genome Project databases...
June 2018: Oncology Letters
Yuqin Zang, Lina Gu, Yanfang Zhang, Yingmei Wang, Fengxia Xue
Uterine leiomyosarcoma (uLMS) is a rare but malignant gynaecological tumour with a poor survival outcome. The present study was aimed at identifying the key genes and pathways in the development of uLMS through bioinformatics analysis. To minimize the frequency of false-positive results of the bioinformatics analysis, 3 microarrays including GSE764, GSE64763 and GSE68312 were downloaded from Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) were screened out using the online tool GEO2R. Then, Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes pathway enrichment analyses were performed using the Database for Annotation, Visualization and Integrated Discovery...
June 2018: Oncology Letters
Dongjie Liu, Rui Li, Xianghua Guo, Lijun Pang, Yunjin Zang, Kai Liu, Dexi Chen
Overexpression of apoptosis-stimulating of p53 protein 2 (ASPP2) can induce apoptotic cell death in hepatoma cells, which contributes to a killing effect of ASPP2 on treating hepatocellular carcinoma (HCC). In the present study, ASPP2 overexpression failed to induce apoptotic cell death in the HCC Huh7.5 cell line, but promoted autophagy development by inhibiting AKT/mTOR pathway. Inhibition of autophagy using 3-methyladenosine recovered the function of ASPP2 on inducing apoptotic cell death, indicating that ASPP2-induced autophagy has an anti-apoptotic role in Huh7...
June 2018: Oncology Letters
Hiromi Sasaki, Satoshi Nagano, Masahiro Yokouchi, Takao Setoguchi, Hirofumi Shimada, Takuya Yamamoto, Yasuhiro Ishidou, Setsuro Komiya
Although it is thought that the surgical enucleation of schwannomas can be easily performed, certain patients present with postoperative neurological symptoms. The present study examined the utility of intraoperative motor-evoked potential (MEP) in predicting neurological deficits following the surgical enucleation of peripheral nerve schwannoma. The current study included 23 patients and MEP was performed using transcranial electrical stimulation. In three cases, the MEP decreased to <50% of the preoperative value; however, in two cases that involved the peroneal nerve and tibial nerve, results appeared to be false positives induced by a tourniquet during surgery...
June 2018: Oncology Letters
Juan An, Chuan-Hao Tang, Na Wang, Yi Liu, Jin Lv, Bin Xu, Xiao-Yan Li, Wan-Feng Guo, Hong-Jun Gao, Kun He, Xiao-Qing Liu
Epidermal growth factor receptor (EGFR) mutation is an important predictor for response to personalized treatments of patients with advanced non-small-cell lung cancer (NSCLC). However its usage is limited due to the difficult of obtaining tissue specimens. A novel prediction system using matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has been reported to be a perspective tool in European countries to identify patients who are likely to benefit from EGFR tyrosine kinase inhibitor (TKI) treatment...
June 2018: Oncology Letters
Licheng Xu, Zhi Liang, Shuyan Li, Jianjun Ma
Breast cancer is the most common cause of cancer-associated mortality and the most frequently diagnosed type of cancer in women worldwide. It has been revealed that the chemokine C-X-C motif chemokine ligand 13 (CXCL13) serves a pivotal role in breast cancer growth and is associated with lymph node metastasis. However, to the best of our knowledge, the mechanism by which CXCL13 mediates breast cancer growth remains uncharacterized. Female BALB/c mice were used in this study. Tumor volume was calculated and changes of gross tumor morphology were observed by hematoxylin and eosin staining...
June 2018: Oncology Letters
Wei Liu, Yanmiao Huo, Jianyu Yang, Xueliang Fu, Minwei Yang, Lingye Tao, Dejun Liu, Junfeng Zhang, Rong Hua, Yongwei Sun
The present study aimed to investigate the expression level of ubiquitin specific peptidase 9X (USP9X) and its clinical significance in Chinese patients with pancreatic ductal adenocarcinoma (PDAC). The mRNA expression levels of USP9X in 30 paired PDAC tissue samples were examined by reverse transcription-quantitative polymerase chain reaction. The protein expression of USP9X was analyzed by immunohistochemistry (IHC) in a tissue microarray containing 205 PDAC specimens. All analyses were performed by SPSS 20...
June 2018: Oncology Letters
Juwita N Rahmat, Kesavan Esuvaranathan, Ratha Mahendran
Bacillus Calmette-Guérin (BCG) immunotherapy is the standard therapy for non-muscle invasive bladder cancer. The aim of the present study was to identify genes that are induced in response to BCG immunotherapy, as these may be potential biomarkers for the response to clinical therapy. To model clinical therapy, human bladder cancer cell lines were incubated with BCG (live or lyophilized BCG Connaught) for 2 h. RNA was extracted and evaluated by Representational Differential Analysis (RDA) and oligo arrays...
June 2018: Oncology Letters
Yunhai Li, Jing Huang, Dejuan Yang, Shili Xiang, Jiazheng Sun, Hongzhong Li, Guosheng Ren
E2Fs, as a family of pivotal transcription factors, have been implicated in multiple biological functions in human cancer; however, the expression and prognostic significance of E2Fs in breast cancer remains unknown. In the present study, the mRNA expression patterns of E2Fs in breast cancer were investigated with Oncomine and The Cancer Genome Atlas data. Prognostic values of E2Fs for patients with breast cancer were determined using the Kaplan-Meier plotter database. The results strongly indicated that E2F1, E2F2, E2F3, E2F5, E2F7 and E2F8 were overexpressed in patients with breast cancer, whereas E2F4 and E2F6 exhibited no expression difference between patients with cancer and healthy controls...
June 2018: Oncology Letters
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