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Toxins

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https://www.readbyqxmd.com/read/29351197/announcing-the-2018-toxins-travel-awards-for-post-doctoral-fellows
#1
EDITORIAL
Jay W Fox
This year we enjoyed a large number of very highy meritorious applications for our annual Toxins Travel Awards.[...].
January 19, 2018: Toxins
https://www.readbyqxmd.com/read/29346316/chronic-dietary-intake-of-enniatin-b-in-broiler-chickens-has-low-impact-on-intestinal-morphometry-and-hepatic-histology-and-shows-limited-transfer-to-liver-tissue
#2
Sophie Fraeyman, Siska Croubels, Mathias Devreese, Richard Ducatelle, Michael Rychlik, Gunther Antonissen
The Fusarium mycotoxin enniatin B (ENN B) is a so-called emerging mycotoxin frequently contaminating poultry feed. To investigate the impact of chronic ENN B exposure on animal health, broiler chickens were fed either a diet naturally contaminated with ENN B (2352 µg/kg) or a control diet (135 µg/kg) for 2, 7, 14, or 21 days. ENN B concentrations were determined in plasma and liver using a validated ultra-high performance liquid chromatography-tandem mass spectrometry UHPLC-MS/MS method. Liver was evaluated histologically, and the villus length and crypt depth of the duodenum, jejunum, and ileum were measured...
January 18, 2018: Toxins
https://www.readbyqxmd.com/read/29346271/-bacterial-toxins-section-in-the-journal-toxins-a-fantastic-multidisciplinary-interplay-between-bacterial-pathogenicity-mechanisms-physiological-processes-genomic-evolution-and-subsequent-development-of-identification-methods-efficient-treatment-and-prevention
#3
EDITORIAL
Michel R Popoff
Toxins are powerful pathogenicity factors produced by certain bacteria, fungi, animals, and plants which mediate drastic interactions of these pathogens on the organism host[...].
January 18, 2018: Toxins
https://www.readbyqxmd.com/read/29342943/the-peptide-pnpp-19-a-spider-toxin-derivative-activates-%C3%AE-opioid-receptors-and-modulates-calcium-channels
#4
Ana C N Freitas, Steve Peigneur, Flávio H P Macedo, José E Menezes-Filho, Paul Millns, Liciane F Medeiros, Maria A Arruda, Jader Cruz, Nicholas D Holliday, Jan Tytgat, Gareth Hathway, Maria E de Lima
The synthetic peptide PnPP-19 comprehends 19 amino acid residues and it represents part of the primary structure of the toxin δ-CNTX-Pn1c (PnTx2-6), isolated from the venom of the spider Phoneutria nigriventer. Behavioural tests suggest that PnPP-19 induces antinociception by activation of CB1, μ and δ opioid receptors. Since the peripheral and central antinociception induced by PnPP-19 involves opioid activation, the aim of this work was to identify whether this synthetic peptide could directly activate opioid receptors and investigate the subtype selectivity for μ-, δ- and/or κ-opioid receptors...
January 15, 2018: Toxins
https://www.readbyqxmd.com/read/29342849/comparative-response-of-the-hepatic-transcriptomes-of-domesticated-and-wild-turkey-to-aflatoxin-b%C3%A2
#5
Kent M Reed, Kristelle M Mendoza, Juan E Abrahante, Roger A Coulombe
The food-borne mycotoxin aflatoxin B₁ (AFB₁) poses a significant risk to poultry, which are highly susceptible to its hepatotoxic effects. Domesticated turkeys (Meleagris gallopavo) are especially sensitive, whereas wild turkeys (M. g. silvestris) are more resistant. AFB₁ toxicity entails bioactivation by hepatic cytochrome P450s to the electrophilic exo-AFB₁-8,9-epoxide (AFBO). Domesticated turkeys lack functional hepatic GST-mediated detoxification of AFBO, and this is largely responsible for the differences in resistance between turkey types...
January 13, 2018: Toxins
https://www.readbyqxmd.com/read/29329271/transketolase-is-identified-as-a-target-of-herbicidal-substance-%C3%AE-terthienyl-by-proteomics
#6
Bin Zhao, Jingqian Huo, Ning Liu, Jinlin Zhang, Jingao Dong
α-terthienyl is a natural phytotoxin isolated originally from Flaveria bidentis (L.) Kuntze. The bioassay presented here shows the strong herbicidal activity of α-terthienyl on Digitaria sanguinalis, Arabidopsis thaliana and Chlamydomonas reinhardtii. The α-terthienyl-induced response of A. thaliana at the protein level was analyzed at different times. Changes in the protein expression profiles were analyzed by two-dimensional gel electrophoresis and liquid chromatography tandem mass spectrometry (LC-MS/MS) mass spectrometry...
January 12, 2018: Toxins
https://www.readbyqxmd.com/read/29329218/molecular-and-physiological-effects-on-the-small-intestine-of-weaner-pigs-following-feeding-with-deoxynivalenol-contaminated-feed
#7
J Alex Pasternak, Vaishnavi Iyer Aka Aiyer, Glenn Hamonic, A Denise Beaulieu, Daniel A Columbus, Heather L Wilson
We intended to assess how exposure of piglets to deoxynivalenol (DON)-contaminated feed impacted their growth, immune response and gut development. Piglets were fed traditional Phase I, Phase II and Phase III diets with the control group receiving 0.20-0.40 ppm DON (referred to as the Control group) and treatment group receiving much higher level of DON-contaminated wheat (3.30-3.80 ppm; referred to as DON-contaminated group). Feeding a DON-contaminated diet had no impact on average daily feed intake (ADFI) (p < 0...
January 12, 2018: Toxins
https://www.readbyqxmd.com/read/29324646/analysis-of-microcystins-in-cyanobacterial-blooms-from-freshwater-bodies-in-england
#8
Andrew D Turner, Monika Dhanji-Rapkova, Alison O'Neill, Lewis Coates, Adam Lewis, Katy Lewis
Cyanobacterial blooms in freshwater bodies in England are currently monitored reactively, with samples containing more than 20,000 cells/mL of potentially toxin-producing species by light microscopy resulting in action by the water body owner. Whilst significantly reducing the risk of microcystin exposure, there is little data describing the levels of these toxins present in cyanobacterial blooms. This study focused on the quantitative LC-MS/MS analysis of microcystins in freshwater samples, collected across England during 2016 and found to contain potentially toxin-producing cyanobacteria...
January 11, 2018: Toxins
https://www.readbyqxmd.com/read/29320435/updated-overview-of-infrared-spectroscopy-methods-for-detecting-mycotoxins-on-cereals-corn-wheat-and-barley
#9
REVIEW
Cecile Levasseur-Garcia
Each year, mycotoxins cause economic losses of several billion US dollars worldwide. Consequently, methods must be developed, for producers and cereal manufacturers, to detect these toxins and to comply with regulations. Chromatographic reference methods are time consuming and costly. Thus, alternative methods such as infrared spectroscopy are being increasingly developed to provide simple, rapid, and nondestructive methods to detect mycotoxins. This article reviews research conducted over the last eight years into the use of near-infrared and mid-infrared spectroscopy to monitor mycotoxins in corn, wheat, and barley...
January 10, 2018: Toxins
https://www.readbyqxmd.com/read/29316724/biochemical-and-clinical-impact-of-organic-uremic-retention-solutes-a-comprehensive-update
#10
REVIEW
Raymond Vanholder, Anneleen Pletinck, Eva Schepers, Griet Glorieux
In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized. We classified these compounds along their physico-chemical characteristics as small water-soluble compounds or groups, protein bound compounds and middle molecules. All but one solute (glomerulopressin) affected at least one mechanism with the potential to contribute to the uremic syndrome. In general, several mechanisms were influenced for each individual solute or group of solutes, with some impacting up to 7 different biological systems of the 11 considered...
January 8, 2018: Toxins
https://www.readbyqxmd.com/read/29316700/sea-anemones-quiet-achievers-in-the-field-of-peptide-toxins
#11
REVIEW
Peter J Prentis, Ana Pavasovic, Raymond S Norton
Sea anemones have been understudied as a source of peptide and protein toxins, with relatively few examined as a source of new pharmacological tools or therapeutic leads. This is surprising given the success of some anemone peptides that have been tested, such as the potassium channel blocker from Stichodactyla helianthus known as ShK. An analogue of this peptide, ShK-186, which is now known as dalazatide, has successfully completed Phase 1 clinical trials and is about to enter Phase 2 trials for the treatment of autoimmune diseases...
January 8, 2018: Toxins
https://www.readbyqxmd.com/read/29316683/biological-and-proteolytic-variation-in-the-venom-of-crotalus-scutulatus-scutulatus-from-mexico
#12
Miguel Borja, Edgar Neri-Castro, Gamaliel Castañeda-Gaytán, Jason L Strickland, Christopher L Parkinson, Juan Castañeda-Gaytán, Roberto Ponce-López, Bruno Lomonte, Alejandro Olvera-Rodríguez, Alejandro Alagón, Rebeca Pérez-Morales
Rattlesnake venoms may be classified according to the presence/absence and relative abundance of the neurotoxic phospholipases A 2 s (PLA 2 s), such as Mojave toxin, and snake venom metalloproteinases (SVMPs). In Mexico, studies to determine venom variation in Mojave Rattlesnakes (Crotalus scutulatus scutulatus) are limited and little is known about the biological and proteolytic activities in this species. Tissue (34) and venom (29) samples were obtained from C. s. scutulatus from different locations within their distribution in Mexico...
January 8, 2018: Toxins
https://www.readbyqxmd.com/read/29316656/azemiopsin-a-selective-peptide-antagonist-of-muscle-nicotinic-acetylcholine-receptor-preclinical-evaluation-as-a-local-muscle-relaxant
#13
Irina V Shelukhina, Maxim N Zhmak, Alexander V Lobanov, Igor A Ivanov, Alexandra I Garifulina, Irina N Kravchenko, Ekaterina A Rasskazova, Margarita A Salmova, Elena A Tukhovskaya, Vladimir A Rykov, Gulsara A Slashcheva, Natalya S Egorova, Inessa S Muzyka, Victor I Tsetlin, Yuri N Utkin
Azemiopsin (Az), a linear peptide from the Azemiops feae viper venom, contains no disulfide bonds, is a high-affinity and selective inhibitor of nicotinic acetylcholine receptor (nAChR) of muscle type and may be considered as potentially applicable nondepolarizing muscle relaxant. In this study, we investigated its preclinical profile in regard to in vitro and in vivo efficacy, acute and chronic toxicity, pharmacokinetics, allergenic capacity, immunotoxicity and mutagenic potency. The peptide effectively inhibited (IC50 ~ 19 nM) calcium response of muscle nAChR evoked by 30 μM (EC100) acetylcholine but was less potent (IC50 ~ 3 μM) at α7 nAChR activated by 10 μM (EC50) acetylcholine and had a low affinity to α4β2 and α3-containing nAChR, as well as to GABAA or 5HT₃ receptors...
January 7, 2018: Toxins
https://www.readbyqxmd.com/read/29316610/development-of-a-deimmunized-bispecific-immunotoxin-ddt2219-against-b-cell-malignancies
#14
Joerg U Schmohl, Deborah Todhunter, Elizabeth Taras, Veronika Bachanova, Daniel A Vallera
Diphtheria toxin (DT) related targeted toxins are effective in cancer treatment, but efficacy diminishes in time because of their immunogenic potential and/or former vaccinations. In order to overcome this limitation for DT2219, a promising bispecific targeted toxin which targets CD19 and CD22, we deimmunized the DT moiety, and thereby developed an exciting improved drug (dDT2219) which still has the potential to sufficiently target B-cell malignancies but also limits clearance because of its reduced immunogenicity...
January 6, 2018: Toxins
https://www.readbyqxmd.com/read/29304012/light-irradiation-wavelength-and-intensity-changes-influence-aflatoxin-synthesis-in-fungi
#15
Tadahiro Suzuki
Fungi respond to light irradiation by forming conidia and occasionally synthesizing mycotoxins. Several light wavelengths, such as blue and red, affect the latter. However, the relationship between light irradiation and mycotoxin synthesis varies depending on the fungal species or strain. This study focused on aflatoxin (AF), which is a mycotoxin, and the types of light irradiation that increase AF synthesis. Light-irradiation tests using the visible region indicated that blue wavelengths in the lower 500 nm region promoted AF synthesis...
January 5, 2018: Toxins
https://www.readbyqxmd.com/read/29304008/biological-control-products-for-aflatoxin-prevention-in-italy-commercial-field-evaluation-of-atoxigenic-aspergillus-flavus-active-ingredients
#16
Antonio Mauro, Esther Garcia-Cela, Amedeo Pietri, Peter J Cotty, Paola Battilani
Since 2003, non-compliant aflatoxin concentrations have been detected in maize produced in Italy. The most successful worldwide experiments in aflatoxin prevention resulted from distribution of atoxigenic strains of Aspergillusflavus to displace aflatoxin-producers during crop development. The displacement results in lower aflatoxin concentrations in harvested grain. The current study evaluated in field performances of two atoxigenic strains of A. flavus endemic to Italy in artificially inoculated maize ears and in naturally contaminated maize...
January 5, 2018: Toxins
https://www.readbyqxmd.com/read/29303983/a-dipteran-s-novel-sucker-punch-evolution-of-arthropod-atypical-venom-with-a-neurotoxic-component-in-robber-flies-asilidae-diptera
#17
Stephan Holger Drukewitz, Nico Fuhrmann, Eivind A B Undheim, Alexander Blanke, Julien Giribaldi, Rosanna Mary, Guillaume Laconde, Sébastien Dutertre, Björn Marcus von Reumont
Predatory robber flies (Diptera, Asilidae) have been suspected to be venomous due to their ability to overpower well-defended prey. However, details of their venom composition and toxin arsenal remained unknown. Here, we provide a detailed characterization of the venom system of robber flies through the application of comparative transcriptomics, proteomics and functional morphology. Our results reveal asilid venoms to be dominated by peptides and non-enzymatic proteins, and that the majority of components in the crude venom is represented by just ten toxin families, which we have named Asilidin1-10...
January 5, 2018: Toxins
https://www.readbyqxmd.com/read/29300300/determination-of-multi-class-mycotoxins-in-tartary-buckwheat-by-ultra-fast-liquid-chromatography-coupled-with-triple-quadrupole-mass-spectrometry
#18
Guixing Ren, Yichen Hu, Jinming Zhang, Liang Zou, Gang Zhao
Considering crops are susceptible to toxicogenic fungi during plantation, pre-processing and storage, an ultra-fast liquid chromatography coupled with triple quadrupole mass spectrometry (UFLC-QTrap-MS/MS) method was developed and validated for simultaneous determination of the 12 most frequent mycotoxins, including aflatoxin B₁, B₂, G₁, G₂, HT-2, T-2 toxin, ochratoxin A, fumonisin B₁, B₂, zearalanone, zearalenone, and deoxynivalenol, in 14 batches of Tartary buckwheat cultivar, collected from different origins in Sichuan Province, China...
January 4, 2018: Toxins
https://www.readbyqxmd.com/read/29301317/correction-of-malocclusion-by-botulinum-neurotoxin-injection-into-masticatory-muscles
#19
REVIEW
Hyun Seok, Seong-Gon Kim
Botulinum toxin (BTX) is a neurotoxin, and its injection in masticatory muscles induces muscle weakness and paralysis. This paralytic effect of BTX induces growth retardation of the maxillofacial bones, changes in dental eruption and occlusion state, and facial asymmetry. Using masticatory muscle paralysis and its effect via BTX, BTX can be used for the correction of malocclusion after orthognathic surgery and mandible fracture. The paralysis of specific masticatory muscles by BTX injection reduces the tensional force to the mandible and prevents relapse and changes in dental occlusion...
January 2, 2018: Toxins
https://www.readbyqxmd.com/read/29301315/protective-and-detoxifying-effects-conferred-by-dietary-selenium-and-curcumin-against-afb1-mediated-toxicity-in-livestock-a-review
#20
REVIEW
Aniket Limaye, Roch-Chui Yu, Cheng-Chun Chou, Je-Ruei Liu, Kuan-Chen Cheng
Aflatoxin B1 (AFB1), among other aflatoxins of the aflatoxin family, is the most carcinogenic and hazardous mycotoxin to animals and human beings with very high potency leading to aflatoxicosis. Selenium is an essential trace mineral possessing powerful antioxidant functions. Selenium is widely reported as an effective antioxidant against aflatoxicosis. By preventing oxidative liver damage, suppressing pro-apoptotic proteins and improving immune status in AFB1 affected animals; selenium confers specific protection against AFB1 toxicity...
January 2, 2018: Toxins
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