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Mediterranean Journal of Hematology and Infectious Diseases

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https://www.readbyqxmd.com/read/30002802/thrombocytopenia-in-patients-with-myelodysplastic-syndromes-still-an-unsolved-problem
#1
REVIEW
May Basood, Howard S Oster, Moshe Mittelman
The myelodysplastic syndromes (MDS) are a group of clonal bone marrow (BM) stem cell disorders, characterized by ineffective hematopoiesis, peripheral cytopenias, and hematologic cellular dysfunction, as well as potential transformation to acute leukemia. Thrombocytopenia is common in MDS and is associated with bleeding complications, occasionally life-threatening. Low platelet count (PLT), as well declining PLT also serves as a prognostic marker. Understanding thrombopoiesis led to the cloning of thrombopoietin, resulting in the development of platelet stimulating agents, thrombomimetics, romiplostim and eltrombopag...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30002801/acute-promyelocytic-leukemia-in-children-a-single-centre-experience-from-turkey
#2
Tekin Aksu, Ali Fettah, İkbal Ok Bozkaya, Mehmet Baştemur, Abdurrahman Kara, Vildan Koşan Çulha, Namık Yaşar Özbek, Neşe Yaralı
Background and objectives: Acute promyelocytic leukemia (APL), is a distinct subtype of acute myeloid leukemia (AML) characterized by a tendency to hemorrhage and excellent response to all-trans retinoic acid (ATRA). In this retrospective study, we aimed to determine the incidence, clinical symptoms, toxicities, and outcome of children with APL in our center. Methods: We retrospectively reviewed the medical records of children (age < 18 years) diagnosed with APL in our pediatric hematology department between January 2006-December 2016...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30002800/evaluation-of-polymyxin-b-susceptibility-profile-and-detection-of-drug-resistance-genes-among-acinetobacter-baumannii-clinical-isolates-in-tehran-iran-during-2015-2016
#3
Reza Mirnejad, Mohsen Heidary, Aghil Bahramian, Mehdi Goudarzi, Abazar Pournajaf
Acinetobacter baumannii is an important opportunistic pathogen, responsible for approximately 10% of all gram-negative nosocomial infection. The aim of this study was to determine aminoglycoside and quinolone resistance genes and their antimicrobial susceptibility profile in the clinically A. baumannii . In this cross-sectional study, a total of 100 nonduplicative A. baumannii isolates were collected from different clinical samples. Antimicrobial susceptibility test was performed by disk diffusion method. QnrA, anrB, qnrS, aac(3)-IIa, and aac(6')-Ib genes were identified using PCR method...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30002799/successful-management-of-kaposiform-hemangioendothelioma-with-long-term-sirolimus-treatment-a-case-report-and-review-of-the-literature
#4
Matteo Chinello, Daniela Di Carlo, Francesca Olivieri, Rita Balter, Massimiliano De Bortoli, Virginia Vitale, Ada Zaccaron, Elisa Bonetti, Alice Parisi, Simone Cesaro
Background: Kaposiform Hemangioendothelioma (KHE) is a rare vascular tumour of the infancy and the first decade of life. It is locally aggressive and potentially life threatening when associated with consumptive coagulopathy, known as Kasabach-Merritt syndrome (KMS). No consensus or guideline for the therapy has been reached because of the lack of prospective trials, and the different standard care suggestions are based on retrospective case series. Case report: We report the case of a 9-month-old male with KHE and KMS in which the initial response, obtained with prednisone and vincristine, was subsequently consolidated and strengthened by long-term treatment with sirolimus, a mTOR inhibitor...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30002798/prevalence-of-%C3%AE-thalassemia-mutations-among-northeastern-iranian-population-and-their-impacts-on-hematological-indices-and-application-of-prenatal-diagnosis-a-seven-years-study
#5
Mohammad Ehsan Jaripour, Kourosh Hayatigolkhatmi, Vahid Iranmanesh, Farhad Khadivi Zand, Zahra Badiei, Hamid Farhangi, Ali Ghasemi, Abdollah Banihashem, Reza Jafarzadeh Esfehani, Ariane Sadr-Nabavi
Background and Objective: β-thalassemia results from a diverse range of mutations inside the hemoglobin subunit β ( HBB ) gene. In a study of β-thalassemia carriers and some of their at-risk fetuses in the Khorasan province of Iran, we aimed to recognize the most common mutations in the region. We also investigated a possible link between these mutations and some of the relevant hematological indices. Methods: Amplification-refractory mutation system-PCR (ARMS-PCR) was used to detect the typical HBB mutations among 1593 individuals, suspected of having a mutated HBB allele from March/2011 to January/2018...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30002797/impact-of-multiplex-pcr-in-reducing-the-risk-of-residual-transfusion-transmitted-human-immunodeficiency-and-hepatitis-b-and-c-viruses-in-burkina-faso
#6
Arzouma Paul Yooda, Serge Theophile Soubeiga, K Yacouba Nebie, Birama Diarra, Salam Sawadogo, Abdoul Karim Ouattara, Dorcas Obiri-Yeboah, Albert Theophane Yonli, Issoufou Tao, Pegdwende Abel Sorgho, Honorine Dahourou, Jacques Simpore
Background and Objective: The improved performance of serological tests has significantly reduced the risk of human immunodeficiency and hepatitis B and C viruses transmission by blood transfusion, but there is a persistence of residual risk. The objective of this study was to evaluate the impact of multiplex PCR in reducing the risk of residual transmission of these viruses in seronegative blood donors in Burkina Faso. Methods: This cross-sectional study was conducted from March to September 2017...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30002796/disseminated-histoplasmosis-as-aids-presentation-case-report-and-comprehensive-review-of-current-literature
#7
REVIEW
Paola Zanotti, Claudia Chirico, Maurizio Gulletta, Laura Ardighieri, Salvatore Casari, Eugenia Quiros Roldan, Ilaria Izzo, Gabriele Pinsi, Giovanni Lorenzin, Fabio Facchetti, Francesco Castelli, Emanuele Focà
Progressive disseminated histoplasmosis (PDH) is an AIDS-defining illness with a high lethality rate if not promptly treated. The wide range of its possible clinical manifestations represents the main barrier to diagnosis in non-endemic countries. Here we present a case of PDH with haemophagocytic syndrome in a newly diagnosed HIV patient and a comprehensive review of disseminated histoplasmosis focused on epidemiology, clinical features, diagnostic tools and treatment options in HIV-infected patients.
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30002795/infections-in-myelodysplastic-syndrome-in-relation-to-stage-and-therapy
#8
REVIEW
Giuseppe Leone, Livio Pagano
Infections remain a significant problem in myelodysplastic syndromes (MDS) in treated as well in non-treated patients and assume a particular complexity. The susceptibility to infections is due, in the absence of intensive chemotherapies, mainly to functional defects in the myeloid lineage with or without neutropenia. Furthermore, MDS includes a heterogeneous group of patients with very different prognosis, therapy and risk factors regarding survival and infections. You should distinguish risk factors related to the disease, like as neutrophils function impairment, neutropenia, unfavorable cytogenetics and bone marrow insufficiency; factors related to the patient, like as age and comorbidities, and factors related to the therapy...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30002794/oral-nutritional-supplementation-in-children-treated-for-cancer-in-low-and-middle-income-countries-is-feasible-and-effective-the-experience-of-the-children-s-hospital-manuel-de-jesus-rivera-la-mascota-in-nicaragua
#9
Nicolò Peccatori, Roberta Ortiz, Emanuela Rossi, Patricia Calderon, Valentino Conter, Yesly García, Andrea Biondi, Darrel Espinoza, Francesco Ceppi, Luvy Mendieta, Maria Luisa Melzi
Children with cancer are particularly vulnerable to malnutrition, which can affect their tolerance of chemotherapy and outcome. In Nicaragua approximately two-thirds of children diagnosed with cancer present with under-nutrition. A nutritional program for children with cancer has been developed at "La Mascota" Hospital. Results of this oral nutritional intervention including difficulties, benefits, and relevance for children treated for cancer in low- and middle-income countries are here reported and discussed...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30002793/very-early-development-and-recognition-of-coronary-involvement-in-a-febrile-infant-with-typical-signs-of-kawasaki-disease
#10
D Buonsenso, S Cristaldi, A Reale, I Tarissi de Jacobis, L Granata, A Marchesi
Kawasaki disease (KD) is an acute, self-limited, inflammatory disease affecting medium-sized arteries and particularly the coronary arteries in about 25% of untreated cases. KD is a clinical diagnosis based on the presence of ≥5 days of fever and the presence of ≥4 of the 5 principal clinical criteria. We described, for the first time to our knowledge, a case of a very early development (on day 1) of typical KD with transient coronary involvement, diagnosed on day 2 of disease and treated with aspirin and steroids on day 3, with complete resolution of clinical signs and coronary involvement...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30002792/clonal-t-cell-large-granular-lymphocytic-disorders-manifesting-in-patients-with-hiv-1-infection-case-series-and-review-of-the-literature
#11
Ashley Rose, Leidy Isenalumhe, Magali Van den Bergh, Lubomir Sokol
We report five patients with human immunodeficiency virus-1/acquired immunodeficiency syndrome (HIV-1/AIDS) who developed T-cell large granular lymphocytic proliferation (T-LGLP) or leukemia (T-LGLL). None of the patients fulfilled criteria for diagnosis of diffuse infiltrative lymphocyte syndrome (DILS) or HIV-associated CD8+ lymphocytosis syndrome at the time of diagnosis of LGL. The immunophenotype of malignant T-cells was identical in three patients with co-expression of CD3, CD8, CD57, and T-cell receptor (TCR) alpha/beta...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29757336/formulas-for-the-detection-%C3%AE-thalassemia-carriers-are-affected-by-changes-in-red-cell-parameters
#12
COMMENT
Deniz Aslan
No abstract text is available yet for this article.
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29755712/lymphoproliferative-syndromes-associated-with-human-herpesvirus-6a-and-human-herpesvirus-6b
#13
REVIEW
Eva Eliassen, Gerhard Krueger, Mario Luppi, Dharam Ablashi
Human herpesvirus 6A and 6B (HHV-6A and HHV-6B) have been noted since their discovery for their T-lymphotropism. Although it has proven difficult to determine the extent to which HHV-6A and HHV-6B are involved in the pathogenesis of many diseases, evidence suggests that primary infection and reactivation of both viruses may induce or contribute to the progression of several lymphoproliferative disorders, ranging from benign to malignant and including infectious mononucleosis-like illness, drug induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS), and nodular sclerosis Hodgkin's lymphoma...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29755711/parasitic-hypereosinophilia-in-childhood-a-diagnostic-challenge
#14
Roberto Antonucci, Nadia Vacca, Giulia Boz, Cristian Locci, Rosanna Mannazzu, Claudio Cherchi, Giacomo Lai, Claudio Fozza
Severe hypereosinophilia (HE) in children is rare, and its etiological diagnosis is challenging. We describe a case of a 30-month-old boy, living in a rural area, who was admitted to our Clinic with a 7-day history of fever and severe hypereosinophilia. A comprehensive diagnostic workup could not identify the cause of this condition. On day 6, the rapidly increasing eosinophil count (maximum value of 56,000/mm3 ), the risk of developing hypereosinophilic syndrome, and the patient's history prompted us to undertake an empiric treatment with albendazole...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29755710/laboratory-biomarkers-to-facilitate-differential-diagnosis-between-measles-and-kawasaki-disease-in-a-pediatric-emergency-room-a-retrospective-study
#15
Danilo Buonsenso, Giulia Macchiarulo, Maria Chiara Supino, Francesco La Penna, Simona Scateni, Alessandra Marchesi, Antonino Reale, Elena Boccuzzi
This retrospective study was conducted to analyze clinical and laboratoristic parameters to individuate specific differences and facilitate differential diagnosis between Measles and Kawasaki Disease (KD) at first evaluation in an emergency room. We found similar clinical features as duration of fever and number of KD criteria (p > 0.5) but significant differences in white blood cell count, neutrophils, CRP and LDH levels (p < 0.001). LDH value ≥ 800 mg/dl had sensibility of 89% and specificity of 90% for Measles while CRP ≥ 3 mg/dl had sensibility 89% and specificity of 85% for KD...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29755709/perioperative-management-of-sickle-cell-disease
#16
REVIEW
Kwame Ofori Adjepong, Folashade Otegbeye, Yaw Amoateng Adjepong
Over 30 million people worldwide have sickle cell disease (SCD). Emergent and non-emergent surgical procedures in SCD have been associated with relatively increased risks of peri-operative mortality, vaso-occlusive (painful) crisis, acute chest syndrome, post-operative infections, congestive heart failure, cerebrovascular accident and acute kidney injury. Pre-operative assessment must include a careful review of the patient's known crisis triggers, baseline hematologic profile, usual transfusion requirements, pre-existing organ dysfunction and opioid use...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29755708/growth-and-endocrine-function-in-tunisian-thalassemia-major-patients
#17
Naouel Guirat Dhouib, Monia Ben Khaled, Monia Ouederni, Habib Besbes, Ridha Kouki, Fethi Mellouli, Mohamed Bejaoui
β-thalassemia major (β-TM) is among the most common hereditary disorders imposing high expenses on health-care system worldwide. The patient's survival is dependent on lifetime blood transfusion which leads to iron overload and its toxicity in various organs including endocrine glands. This article provides an overview of endocrine disorders in beta-TM patients. This single center investigation enrolled 28 β-TM patients (16 males, 12 females) regularly transfused with packed red cell since early years of life...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29755707/decolonization-of-intestinal-carriage-of-mdr-xdr-gram-negative-bacteria-with-oral-colistin-in-patients-with-hematological-malignancies-results-of-a-randomized-controlled-trial
#18
Igor Stoma, Igor Karpov, Igor Iskrov, Svetlana Krivenko, Anatoly Uss, Svetlana Vlasenkova, Irina Lendina, Veronika Cherniak, Dmitrii Suvorov
Background: Intestinal colonization by MDR/XDR gram-negative bacteria leads to an increased risk of subsequent bloodstream infections (BSI) in patients receiving chemotherapy as a treatment for hematologic malignancies. Objectives: The objective of this study was to evaluate the efficacy of oral colistin in eradicating the intestinal carriage of MDR/XDR Gram-negative bacteria in patients with hematological malignancies. Methods: In a tertiary hematology center, adult patients with intestinal colonization by MDR/XDR Gram-negative bacteria were included in a randomized controlled trial (RCT) during a period from November 2016 to October 2017...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29755706/infectious-risks-and-complications-in-adult-leukemic-patients-receiving-blinatumomab
#19
Wonhee So, Shuchi Pandya, Rod Quilitz, Bijal Shah, John N Greene
Background: Blinatumomab is an anti-CD19 immunotherapy approved for relapsed/refractory B-cell acute lymphoblastic leukemia (ALL) with significantly increased survival rate. While blinatumomab showed lower rates of infection, neutropenia and mucosal barrier injury versus chemotherapy, its infection risks are not well described. Methods: All patients who received blinatumomab for ≥ seven days at an academic cancer center from May 2015 to April 2017 were included...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29755705/appropriate-duration-of-intravenous-treatment-of-candidemia-and-timing-of-step-down-to-oral-therapy-in-non-neutropenic-patients
#20
REVIEW
Rita Wilson Dib, Ray Hachem, Anne-Marie Chaftari, Issam Raad
In this review, we have analyzed the available literature pertaining to the total duration of intravenous (IV) therapy and the appropriate timing of step down to oral therapy in the management of candidemia. Overview of the guidelines and literature seem to indicate that a minimum of 14 days of antifungal therapy is required in the treatment of candidemia without deeply seated infection. However, this was never based on evidence. Furthermore, step down to oral therapy seems to be dependent on the clinical stability criteria of the patient with candidemia after 4 to 7 days of IV therapy...
2018: Mediterranean Journal of Hematology and Infectious Diseases
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