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Mediterranean Journal of Hematology and Infectious Diseases

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https://www.readbyqxmd.com/read/30416702/phenotyping-of-rh-kell-duffy-and-kidd-blood-group-antigens-among-non-tribal-and-tribal-population-of-south-gujarat-and-its-implication-in-preventing-alloimmunization-in-multitransfused-patients
#1
Avani Shah, Kanjaksha Ghosh, Preeti Sharma, Kanchan Mishra
No abstract text is available yet for this article.
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416701/cardiac-toxicity-associated-with-hcv-direct-antiviral-agents
#2
Claudio Ucciferri, Alessandro Occhionero, Jacopo Vecchiet, Katia Falasca
No abstract text is available yet for this article.
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416700/megakaryocyte-contribution-to-bone-marrow-fibrosis-many-arrows-in-the-quiver
#3
REVIEW
Alessandro Malara, Vittorio Abbonante, Maria Zingariello, Annarita Migliaccio, Alessandra Balduini
In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. This review article aims to provide an overview of the crucial role of megakaryocytes in myelofibrosis by discussing the role and the altered secretion of megakaryocyte-derived soluble factors, enzymes and extracellular matrices that are known to induce bone marrow fibrosis...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416699/the-broad-ranging-panorama-of-systemic-autoinflammatory-disorders-with-specific-focus-on-acute-painful-symptoms-and-hematologic-manifestations-in-children
#4
REVIEW
Donato Rigante
Systemic autoinflammatory disorders (SAIDs) are inherited defects of innate immunity characterized by recurrent sterile inflammatory attacks involving skin, joints, serosal membranes, gastrointestinal tube, and other tissues, which recur with variable rhythmicity and display reactive amyloidosis as a potential long-term complication. Dysregulated inflammasome activity leading to overproduction of many proinflammatory cytokines, such as interleukin-1 (IL-1), and delayed shutdown of inflammation are considered crucial pathogenic keys in the vast majority of SAIDs...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416698/deferasirox-over-a-decade-of-experience-in-thalassemia
#5
REVIEW
Nour M Moukalled, Rayan Bou-Fakhredin, Ali T Taher
Thalassemia incorporates a broad clinical spectrum characterized by decreased or absent production of normal hemoglobin leading to decreased red blood cell survival and ineffective erythropoiesis. Chronic iron overload remains an inevitable complication resulting from regular blood transfusions (transfusion-dependent) and/or increased iron absorption (mainly non-transfusion-dependent thalassemia), requiring adequate treatment to prevent the significant associated morbidity and mortality. Iron chelation therapy has become a cornerstone in the management of thalassemia patients, leading to improvements in their outcome and quality of life...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416697/cutaneous-manifestations-of-primary-immunodeficiency-diseases-in-tunisian-children
#6
Naouel Guirat Dhouib, Monia Ben Khaled, Monia Ouederni, Imen Ben-Mustapha, Ridha Kouki, Habib Besbes, Mohamed Ridha Barbouche, Fethi Mellouli, Mohamed Bejaoui
Skin manifestations are frequent among patients with primary immunodeficiency diseases (PIDs). Their prevalence varies according to the type of immunodeficiency. This review provides the reader with an up-to-date summary of the common dermatologic manifestations of PIDs among Tunisian children. We conducted a prospective study on two hundred and ninety children with immune deficiency. Demographic details (including age, sex, and consanguinity) with personal and family history were recorded. Special attention was paid to cutaneous manifestations...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416696/jadenu-%C3%A2-substituting-exjade-%C3%A2-in-iron-overloaded-%C3%AE-thalassemia-major-btm-patients-a-preliminary-report-of-the-effects-on-the-tolerability-serum-ferritin-level-liver-iron-concentration-and-biochemical-profiles
#7
Mohamed A Yassin, Ashraf T Soliman, Vincenzo De Sanctis, Radwa M Hussein, Randa Al-Okka, Nancy Kassem, Rula Ghasoub, Ahmed Basha, Abdulqadir J Nashwan, Ahmad M Adel
Introduction: Due to the chronic nature of chelation therapy and the adverse consequences of iron overload, patient adherence to therapy is an important issue. Jadenu ® is a new oral formulation of deferasirox (Exjade ® ) tablets for oral suspension. While Exjade® is a dispersible tablet that must be mixed in liquid and taken on an empty stomach, Jadenu ® can be taken in a single step, with or without a light meal, simplifying administration for the treatment of patients with chronic iron overload...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416695/invasive-fungal-infections-in-patients-with-chronic-lymphoproliferative-disorders-in-the-era-of-target-drugs
#8
REVIEW
Davide Facchinelli, Gessica Marchesini, Gianpaolo Nadali, Livio Pagano
This review summarizes the more recent evidence about epidemiology and risk factors for invasive fungal infections (IFI) in patients affected by Chronic Lymphocytic Leukemia (CLL), indolent Non Hodgkin Lymphoma (iNHL) and Multiple Myeloma (MM). Despite advances in the prognosis and treatment of hematological malignancies in recent years, susceptibility to infection remains a significant challenge to patient care. A large amount of data regarding patients with acute leukemia has been published while little information is available on the incidence of IFI in chronic lymphoproliferative disorders (CLD)...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416694/severe-liver-iron-concentrations-lic-in-24-patients-with-%C3%AE-thalassemia-major-correlations-with-serum-ferritin-liver-enzymes-and-endocrine-complications
#9
Ibrahim Kanbour, Prem Chandra, Ashraf Soliman, Vincenzo De Sanctis, Abdulqadir Nashwan, Sandra Abusamaan, Abbas Moustafa, Mohamed A Yassin
Introduction: Chronic blood transfusion is the mainstay of care for individuals with β-thalassemia major (BTM). However, it causes iron-overload that requires monitoring and management by long-term iron chelation therapy to prevent endocrinopathies and cardiomyopathies, which can be fatal. Hepatic R2 MRI method (FerriScan®) has been validated as the gold standard for evaluation and monitoring liver iron concentration (LIC) that reflects the total body iron-overload. Although adequate oral iron chelation therapy (OIC) is promising for the treatment of transfusional iron-overload, some patients are less compliant with it, and others suffer from long-term effects of iron overload...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416693/human-herpesvirus-8-and-lymphoproliferative-disorders
#10
REVIEW
Maria Luisa Calabrò, Ronit Sarid
The spectrum of lymphoproliferative disorders linked to human herpesvirus 8 (HHV-8) infection has constantly been increasing since the discovery of its first etiologic association with primary effusion lymphoma (PEL). PEL is a rapidly progressing non-Hodgkin's B-cell lymphoma that develops in body cavities in an effusional form. With the increase in the overall survival of PEL patients, as well as the introduction of HHV-8 surveillance in immunocompromised patients, the extracavitary, solid counterpart of PEL was later identified...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416692/insights-into-the-interplay-between-kir-gene-frequencies-and-chronic-hbv-infection-in-burkina-faso
#11
Pegdwendé Abel Sorgho, Jeremy James Martinson, Florencia Wendkuuni Djigma, Albert Théophane Yonli, Bolni Marius Nagalo, Tegwinde Rebeca Compaore, Dorcas Obiri-Yeboah, Birama Diarra, Herman Karim Sombie, Arsène Wendpagnangdé Zongo, Abdoul Karim Ouattara, Serge Théophile R Soubeiga, Lassina Traore, Lewis R Roberts, Jacques Simpore
Background/Objective: Hepatitis B virus (HBV) infection is the leading risk factor for cirrhosis and hepatocellular carcinoma (HCC). The objective of this investigation was to assess the association between "Killer Cell Immunoglobulin-Like Receptor" (KIR) gene frequencies and chronic HBV infection. Methods: Chronic HBV carriers and healthy patients were selected for this study. The viral load for HBV were performed, and SSP-PCR was used to characterize the frequencies of KIR genes...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416691/molecular-expression-of-bone-marrow-angiogenic-factors-cell-cell-adhesion-molecules-and-matrix-metallo-proteinases-in-plasmacellular-disorders-a-molecular-panel-to-%C3%A4-nvestigate-disease-progression
#12
M C Rapanotti, L Franceschini, T M Suarez Viguria, C Ialongo, D Fraboni, R Cerretti, G De Angelis, L Pupo, M Rizzo, M Cantonetti, M Postorino, M T Voso, F Lo-Coco
No abstract text is available yet for this article.
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30416690/the-jak2v617f-point-mutation-increases-the-osteoclast-forming-ability-of-monocytes-in-patients-with-chronic-myeloproliferative-neoplasms-and-makes-their-osteoclasts-more-susceptible-to-jak2-inhibition
#13
Emmanouil Spanoudakis, Menelaos Papoutselis, Ioanna Bazdiara, Eleftheria Lamprianidi, Xrisa Kordella, Constantinos Tilkeridis, Costas Tsatalas, Ioannis Kotsianidis
JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and four age-matched normal donors (ND). Osteoclast forming assays started from selected monocytes also and under titrated concentrations of the JAK2 Inhibitor AG-490 (Tyrphostin). Genomic DNA was extracted from the formed osteoclasts, and the JAK2V617F/JAK2WT genomic DNA ratio was calculated...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30210750/peripheral-nervous-system-involvement-in-lymphoproliferative-disorders
#14
REVIEW
Mario Sabatelli, Luca Laurenti, Marco Luigetti
Peripheral neuropathies are a vast group of diseases with heterogeneous aetiologies, including genetic and acquired causes. Several haematological disorders may cause an impairment of the peripheral nervous system, with diverse mechanisms and variable clinical, electrophysiological and pathological manifestations. In this practical review, we considered the main phenotypes of peripheral nervous system diseases associated with lymphoproliferative disorders. The area of intersection of neurological and haematological fields is of particular complexity and raises specific problems in the clinical practice of lymphoproliferative disorders...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30210749/mutational-profiles-of-f8-and-f9-in-a-cohort-of-haemophilia-a-and-haemophilia-b-patients-in-the-multi-ethnic-malaysian-population
#15
Maimiza Zahari, Siti Aishah Sulaiman, Zulhabri Othman, Yasmin Ayob, Faraizah Abd Karim, Rahman Jamal
Background: Haemophilia A (HA) and Haemophilia B (HB) are X-linked blood disorders that are caused by various mutations in the factor VIII (F8) and factor IX (F9) genes respectively. Identification of mutations is essential as some of the mutations are associated with the development of inhibitors. This study is the first comprehensive study of the F8 mutational profile in Malaysia. Materials and methods: We analysed 100 unrelated HA and 15 unrelated HB patients for genetic alterations in the F8 and F9 genes by using the long-range PCR, DNA sequencing, and the multiplex-ligation-dependent probe amplification assays...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30210748/the-emerging-resistance-in-nosocomial-urinary-tract-infections-from-the-pediatrics-perspective
#16
Fatma Devrim, Erkin Serdaroğlu, İlknur Çağlar, Yeliz Oruç, Nevbahar Demiray, Nuri Bayram, Hasan Ağın, Sebnem Çalkavur, Yelda Sorguç, Nida Dinçel, Yüce Ayhan, Ebru Yılmaz, Ilker Devrim
Background: Healthcare-associated infections results in increased health care costs and mortality. There are limited studies concerning the distribution of the etiologic agents and the resistance patterns of the microorganisms causing healthcare-associated urinary tract infections (HA-UTI) in pediatric settings. Objectives: The aim of this study was to evaluate the distribution and antibiotic susceptibility patterns of pathogens causing HA-UTI in children. Material and Methods: Isolates from 138 children with UTI who were hospitalized in pediatric, neonatal and pediatric surgery intensive care units were reviewed...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30210747/prevalence-of-thalassemia-among-newborns-a-re-visited-after-20-years-of-a-prevention-and-control-program-in-northeast-thailand
#17
Attawut Chaibunruang, Kanda Sornkayasit, Mattanee Chewasateanchai, Peerayoot Sanugul, Goonnapa Fucharoen, Supan Fucharoen
Background: To provide accurate prevalence information of thalassemia in northeast Thailand, authors performed thalassemia screening in newborns after 20 years implementation of a prevention and control program. Methods: Study was done on 350 cord blood specimens collected consecutively at Maternal and Child Hospital, Regional Health Promotion Center 7, Khon Kaen, Thailand. All kinds of α- and β-thalassemias were identified using combined hemoglobin (Hb) and DNA analyses...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30210746/molecular-characterization-of-vancomycin-mupirocin-and-antiseptic-resistant-staphylococcus-aureus-strains
#18
Mahtab Hadadi, Hamid Heidari, Hadi Sedigh Ebrahim-Saraie, Mohammad Motamedifar
Background: Staphylococcus aureus is a common cause of nosocomial infections leading to a broad spectrum of diseases. Increasing antibiotic resistance among S. aureus strains, particularly methicillin-resistant S. aureus (MRSA), is a serious concern. In addition, the emergence of antiseptics resistance in MRSA helps the organism to persist and spread in healthcare environments easily. The aim of this study was to determine the molecular characteristics of vancomycin, mupirocin, and antiseptic resistant S...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30210745/the-spectrum-of-hypereosinophilia-and-associated-clonal-disorders-a-real-world-data-based-on-combined-retrospective-and-prospective-analysis-from-a-tropical-setting
#19
Sreejesh Sreedharanunni, Neelam Varma, Man Updesh Singh Sachdeva, Shano Naseem, Pankaj Malhotra, Deepak Bansal, Amita Trehan, Subhash Varma
Objective: To determine the frequency, etiological spectrum and treatment outcome of hypereosinophilia (HE) and hypereosinophilic syndromes (HES) in a tropical setting. Methods: A retrospective analysis of hospital data of five years (January 2009 to December 2013) and a comprehensive prospective evaluation of patients presenting with HE/HES over a period of 33 months (January 2014 to September 2016) was performed. Results: HE/HES was diagnosed in a total of 125 patients during the study period with an estimated prevalence of 0...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/30210744/outbreak-of-burkholderia-cepacia-infection-a-systematic-study-in-a-hematolooncology-unit-of-a-tertiary-care-hospital-from-eastern-india
#20
Shuvra Neel Baul, Rajib De, Prakas Kumar Mandal, Swagnik Roy, Tuphan Kanti Dolai, Prantar Chakrabarti
Background: Burkholderia cepacia , an aerobic gram-negative bacillus, is a frequent colonizer of fluids used in the hospital ward. It poses little risk of infection to healthy people; however it is a known important opportunistic pathogen causing morbidity and mortality due to its intrinsic resistance to most of the antibiotics in hospitalized patients. Small hospital outbreaks are frequent. B. cepacia may occur as an opportunistic infection in hemato-oncology patients. Here we present an outbreak of Burkholderia cepacia infection in hematology ward of our institute...
2018: Mediterranean Journal of Hematology and Infectious Diseases
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