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Mediterranean Journal of Hematology and Infectious Diseases

Mario Sabatelli, Luca Laurenti, Marco Luigetti
Peripheral neuropathies are a vast group of diseases with heterogeneous aetiologies, including genetic and acquired causes. Several haematological disorders may cause an impairment of the peripheral nervous system, with diverse mechanisms and variable clinical, electrophysiological and pathological manifestations. In this practical review, we considered the main phenotypes of peripheral nervous system diseases associated with lymphoproliferative disorders. The area of intersection of neurological and haematological fields is of particular complexity and raises specific problems in the clinical practice of lymphoproliferative disorders...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Maimiza Zahari, Siti Aishah Sulaiman, Zulhabri Othman, Yasmin Ayob, Faraizah Abd Karim, Rahman Jamal
Background: Haemophilia A (HA) and Haemophilia B (HB) are X-linked blood disorders that are caused by various mutations in the factor VIII (F8) and factor IX (F9) genes respectively. Identification of mutations is essential as some of the mutations are associated with the development of inhibitors. This study is the first comprehensive study of the F8 mutational profile in Malaysia. Materials and methods: We analysed 100 unrelated HA and 15 unrelated HB patients for genetic alterations in the F8 and F9 genes by using the long-range PCR, DNA sequencing, and the multiplex-ligation-dependent probe amplification assays...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Fatma Devrim, Erkin Serdaroğlu, İlknur Çağlar, Yeliz Oruç, Nevbahar Demiray, Nuri Bayram, Hasan Ağın, Sebnem Çalkavur, Yelda Sorguç, Nida Dinçel, Yüce Ayhan, Ebru Yılmaz, Ilker Devrim
Background: Healthcare-associated infections results in increased health care costs and mortality. There are limited studies concerning the distribution of the etiologic agents and the resistance patterns of the microorganisms causing healthcare-associated urinary tract infections (HA-UTI) in pediatric settings. Objectives: The aim of this study was to evaluate the distribution and antibiotic susceptibility patterns of pathogens causing HA-UTI in children. Material and Methods: Isolates from 138 children with UTI who were hospitalized in pediatric, neonatal and pediatric surgery intensive care units were reviewed...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Attawut Chaibunruang, Kanda Sornkayasit, Mattanee Chewasateanchai, Peerayoot Sanugul, Goonnapa Fucharoen, Supan Fucharoen
Background: To provide accurate prevalence information of thalassemia in northeast Thailand, authors performed thalassemia screening in newborns after 20 years implementation of a prevention and control program. Methods: Study was done on 350 cord blood specimens collected consecutively at Maternal and Child Hospital, Regional Health Promotion Center 7, Khon Kaen, Thailand. All kinds of α- and β-thalassemias were identified using combined hemoglobin (Hb) and DNA analyses...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Mahtab Hadadi, Hamid Heidari, Hadi Sedigh Ebrahim-Saraie, Mohammad Motamedifar
Background: Staphylococcus aureus is a common cause of nosocomial infections leading to a broad spectrum of diseases. Increasing antibiotic resistance among S. aureus strains, particularly methicillin-resistant S. aureus (MRSA), is a serious concern. In addition, the emergence of antiseptics resistance in MRSA helps the organism to persist and spread in healthcare environments easily. The aim of this study was to determine the molecular characteristics of vancomycin, mupirocin, and antiseptic resistant S...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Sreejesh Sreedharanunni, Neelam Varma, Man Updesh Singh Sachdeva, Shano Naseem, Pankaj Malhotra, Deepak Bansal, Amita Trehan, Subhash Varma
Objective: To determine the frequency, etiological spectrum and treatment outcome of hypereosinophilia (HE) and hypereosinophilic syndromes (HES) in a tropical setting. Methods: A retrospective analysis of hospital data of five years (January 2009 to December 2013) and a comprehensive prospective evaluation of patients presenting with HE/HES over a period of 33 months (January 2014 to September 2016) was performed. Results: HE/HES was diagnosed in a total of 125 patients during the study period with an estimated prevalence of 0...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Shuvra Neel Baul, Rajib De, Prakas Kumar Mandal, Swagnik Roy, Tuphan Kanti Dolai, Prantar Chakrabarti
Background: Burkholderia cepacia , an aerobic gram-negative bacillus, is a frequent colonizer of fluids used in the hospital ward. It poses little risk of infection to healthy people; however it is a known important opportunistic pathogen causing morbidity and mortality due to its intrinsic resistance to most of the antibiotics in hospitalized patients. Small hospital outbreaks are frequent. B. cepacia may occur as an opportunistic infection in hemato-oncology patients. Here we present an outbreak of Burkholderia cepacia infection in hematology ward of our institute...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Elmoubasher Farag, Devendra Bansal, Mohamad Abdul Halim Chehab, Ayman Al-Dahshan, Mohamed Bala, Nandakumar Ganesan, Yosuf Abdulla Al Abdulla, Mohammed Al Thani, Ali A Sultan, Hamad Al-Romaihi
Background and Objectives: Imported malaria poses a serious public health problem in Qatar because its population is "naïve" to such infection; where local transmission might lead to serious, life-threatening infection and might even trigger epidemics. Methods: This study is a retrospective review of the imported malaria cases in Qatar reported by the malaria surveillance program at the Ministry of Public Health (MoPH), during the period between January 2008 and December 2015...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Sophia Delicou, Konstantinos Maragkos, Maria Tambaki, Dimitrios Kountouras, John Koskinas
Sickle cell disease patients often need regular blood transfusions to improve both the quality of life and survival from the veno-occlusive complications of the disease. Deferasirox, a convenient long acting oral agent, has recently been introduced in clinical practice with promising efficacy. This study aims to evaluate the association of liver stiffness and possible fibrosis with iron deposition and confirm the use of elastography as a validated test of responding to chelation with low cost and easy access...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Athanasia Apsemidou, Nikolaos Petridis, Timoleon-Achilleas Vyzantiadis, Athanasios Tragiannidis
Invasive aspergillosis (IA) is an important cause of infectious morbidity and mortality in immunocompromised paediatric patients. Despite improvements in diagnosis, prevention, and treatment, IA is still associated with high mortality rates. To address this issue, several international societies and organisations have proposed guidelines for the management of IA in the paediatric population. In this article, we review current recommendations of the Infectious Diseases Society of America, the European Conference on Infection in Leukaemia and the European Society of Clinical Microbiology and Infectious Diseases for the management and prevention of IA in children...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Ferhat Arslan, Sehnaz Alp, Yahya Büyükasık, Melda Comert Ozkan, Fahri Şahin, Seniha Basaran, Arif Atahan Cagatay, Ömer Haluk Eraksoy, Kenan Aksu, Barış Ertunç, Volkan Korten, Bahadır Ceylan, Ali Mert
Hemophagocytic Lymphohistiocytosis (HLH) is an indicator of an exaggerated immune response and eventually adverse outcomes. This study aimed to investigate the clinical and laboratory features and outcomes of patients with HLH. The medical records of 26 HLH adult patients (≥ 16 years of age) were retrospectively analyzed. Gender, age, the duration of fever, time to diagnosis, etiology and laboratory data were extracted from the records. The mean age was 38 ± 18 years, and 15 (58%) patients were female. A total of nine cases had infectious diseases; four cases had rheumatologic diseases, three cases had hematological malignancies while nine cases could not have a definitive diagnosis...
2018: Mediterranean Journal of Hematology and Infectious Diseases
May Basood, Howard S Oster, Moshe Mittelman
The myelodysplastic syndromes (MDS) are a group of clonal bone marrow (BM) stem cell disorders, characterized by ineffective hematopoiesis, peripheral cytopenias, and hematologic cellular dysfunction, as well as potential transformation to acute leukemia. Thrombocytopenia is common in MDS and is associated with bleeding complications, occasionally life-threatening. Low platelet count (PLT), as well declining PLT also serves as a prognostic marker. Understanding thrombopoiesis led to the cloning of thrombopoietin, resulting in the development of platelet stimulating agents, thrombomimetics, romiplostim and eltrombopag...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Tekin Aksu, Ali Fettah, İkbal Ok Bozkaya, Mehmet Baştemur, Abdurrahman Kara, Vildan Koşan Çulha, Namık Yaşar Özbek, Neşe Yaralı
Background and objectives: Acute promyelocytic leukemia (APL), is a distinct subtype of acute myeloid leukemia (AML) characterized by a tendency to hemorrhage and excellent response to all-trans retinoic acid (ATRA). In this retrospective study, we aimed to determine the incidence, clinical symptoms, toxicities, and outcome of children with APL in our center. Methods: We retrospectively reviewed the medical records of children (age < 18 years) diagnosed with APL in our pediatric hematology department between January 2006-December 2016...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Reza Mirnejad, Mohsen Heidary, Aghil Bahramian, Mehdi Goudarzi, Abazar Pournajaf
Acinetobacter baumannii is an important opportunistic pathogen, responsible for approximately 10% of all gram-negative nosocomial infection. The aim of this study was to determine aminoglycoside and quinolone resistance genes and their antimicrobial susceptibility profile in the clinically A. baumannii . In this cross-sectional study, a total of 100 nonduplicative A. baumannii isolates were collected from different clinical samples. Antimicrobial susceptibility test was performed by disk diffusion method. QnrA, anrB, qnrS, aac(3)-IIa, and aac(6')-Ib genes were identified using PCR method...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Matteo Chinello, Daniela Di Carlo, Francesca Olivieri, Rita Balter, Massimiliano De Bortoli, Virginia Vitale, Ada Zaccaron, Elisa Bonetti, Alice Parisi, Simone Cesaro
Background: Kaposiform Hemangioendothelioma (KHE) is a rare vascular tumour of the infancy and the first decade of life. It is locally aggressive and potentially life threatening when associated with consumptive coagulopathy, known as Kasabach-Merritt syndrome (KMS). No consensus or guideline for the therapy has been reached because of the lack of prospective trials, and the different standard care suggestions are based on retrospective case series. Case report: We report the case of a 9-month-old male with KHE and KMS in which the initial response, obtained with prednisone and vincristine, was subsequently consolidated and strengthened by long-term treatment with sirolimus, a mTOR inhibitor...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Mohammad Ehsan Jaripour, Kourosh Hayatigolkhatmi, Vahid Iranmanesh, Farhad Khadivi Zand, Zahra Badiei, Hamid Farhangi, Ali Ghasemi, Abdollah Banihashem, Reza Jafarzadeh Esfehani, Ariane Sadr-Nabavi
Background and Objective: β-thalassemia results from a diverse range of mutations inside the hemoglobin subunit β ( HBB ) gene. In a study of β-thalassemia carriers and some of their at-risk fetuses in the Khorasan province of Iran, we aimed to recognize the most common mutations in the region. We also investigated a possible link between these mutations and some of the relevant hematological indices. Methods: Amplification-refractory mutation system-PCR (ARMS-PCR) was used to detect the typical HBB mutations among 1593 individuals, suspected of having a mutated HBB allele from March/2011 to January/2018...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Arzouma Paul Yooda, Serge Theophile Soubeiga, K Yacouba Nebie, Birama Diarra, Salam Sawadogo, Abdoul Karim Ouattara, Dorcas Obiri-Yeboah, Albert Theophane Yonli, Issoufou Tao, Pegdwende Abel Sorgho, Honorine Dahourou, Jacques Simpore
Background and Objective: The improved performance of serological tests has significantly reduced the risk of human immunodeficiency and hepatitis B and C viruses transmission by blood transfusion, but there is a persistence of residual risk. The objective of this study was to evaluate the impact of multiplex PCR in reducing the risk of residual transmission of these viruses in seronegative blood donors in Burkina Faso. Methods: This cross-sectional study was conducted from March to September 2017...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Paola Zanotti, Claudia Chirico, Maurizio Gulletta, Laura Ardighieri, Salvatore Casari, Eugenia Quiros Roldan, Ilaria Izzo, Gabriele Pinsi, Giovanni Lorenzin, Fabio Facchetti, Francesco Castelli, Emanuele Focà
Progressive disseminated histoplasmosis (PDH) is an AIDS-defining illness with a high lethality rate if not promptly treated. The wide range of its possible clinical manifestations represents the main barrier to diagnosis in non-endemic countries. Here we present a case of PDH with haemophagocytic syndrome in a newly diagnosed HIV patient and a comprehensive review of disseminated histoplasmosis focused on epidemiology, clinical features, diagnostic tools and treatment options in HIV-infected patients.
2018: Mediterranean Journal of Hematology and Infectious Diseases
Giuseppe Leone, Livio Pagano
Infections remain a significant problem in myelodysplastic syndromes (MDS) in treated as well in non-treated patients and assume a particular complexity. The susceptibility to infections is due, in the absence of intensive chemotherapies, mainly to functional defects in the myeloid lineage with or without neutropenia. Furthermore, MDS includes a heterogeneous group of patients with very different prognosis, therapy and risk factors regarding survival and infections. You should distinguish risk factors related to the disease, like as neutrophils function impairment, neutropenia, unfavorable cytogenetics and bone marrow insufficiency; factors related to the patient, like as age and comorbidities, and factors related to the therapy...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Nicolò Peccatori, Roberta Ortiz, Emanuela Rossi, Patricia Calderon, Valentino Conter, Yesly García, Andrea Biondi, Darrel Espinoza, Francesco Ceppi, Luvy Mendieta, Maria Luisa Melzi
Children with cancer are particularly vulnerable to malnutrition, which can affect their tolerance of chemotherapy and outcome. In Nicaragua approximately two-thirds of children diagnosed with cancer present with under-nutrition. A nutritional program for children with cancer has been developed at "La Mascota" Hospital. Results of this oral nutritional intervention including difficulties, benefits, and relevance for children treated for cancer in low- and middle-income countries are here reported and discussed...
2018: Mediterranean Journal of Hematology and Infectious Diseases
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