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Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/29662566/focal-increased-tc-99m-mdp-uptake-in-the-nutrient-foramen-of-the-femoral-diaphysis-on-bone-spect-ct
#1
Hwajin Cha, Soo Bin Park, Hyun-Joo Kim
We present images of an 83-year-old female with a history of osteoporosis and bilateral total knee replacement arthroplasty, referred for bone scintigraphy and single-photon emission computed tomography (SPECT)/computed tomography (CT), owing to left knee pain. No trauma to, or intense exercise of, the knee was reported. The bone scan and SPECT/CT revealed a focally increased Tc-99m methylene diphosphonate (MDP) uptake in the medial cortex of the left femoral diaphysis with matched linear radiolucency on CT images...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662565/follicular-lymphoma-mimicking-metastatic-nodes-on-the-f-18-fdg-pet-ct-and-mri-for-staging-of-endometrial-cancer
#2
Seok-Nam Yoon
A 53-year-old woman was diagnosed with endometrial carcinoma by vaginal bleeding. F-18 fluorodeoxy glucose positron emission tomography PET/CT (F-18 FDG PET/CT) scan for staging showed intense focal FDG uptake in the endometrium suggesting endometrial malignancy. PET/CT showed multiple node uptakes in the pericaval region, paraaortic region, common iliac, and both internal iliac and external iliac regions suggesting multiple pelvic and retroperitoneal node metastases. MRI showed multiple metastatic lymphadenopathy in the retroperitoneum and pelvic cavity...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662564/dual-pathologies-of-parathyroid-adenoma-and-papillary-thyroid-cancer-on-fluorocholine-and-fluorodeoxyglucose-pet-ct
#3
N T K Thanseer, Sanjay Kumar Bhadada, Ashwani Sood, Ashwin Singh Parihar, Divya Dahiya, Priyanka Singh, Rajender Kumar Basher, Ashim Das, Bhagwant R Mittal
18 F-Fluorocholine (FCH) PET/CT is evolving as a functional imaging modality for the preoperative imaging of abnormal parathyroid tissue(s) helping to localize eutopic and ectopic parathyroid tissue and limit the extent of surgery. FCH PET/CT may show incidental uptake in various thyroid lesions necessitating further evaluation, whereas the role of 18 F-fluorodeoxyglucose (FDG) PET/CT in the detection of incidental thyroid nodules is well documented. The case of a middle-aged woman with dual pathology of parathyroid adenoma and papillary thyroid cancer detected on FCH and FDG PET/CT is presented...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662563/-123-i-labeled-oxldl-is-widely-distributed-throughout-the-whole-body-in-mice
#4
Atushi Nakano, Hidekazu Kawashima, Yoshinori Miyake, Tsutomu Zeniya, Akihide Yamamoto, Kazuhiro Koshino, Takashi Temma, Tetsuya Fukuda, Yoshiko Fujita, Akemi Kakino, Shigehiko Kanaya, Tatsuya Sawamura, Hidehiro Iida
Purpose: Oxidized low-density lipoprotein (oxLDL) plays a key role in endothelial dysfunction, vascular inflammation, and atherogenesis. The aim of this study was to assess blood clearance and in vivo kinetics of radiolabeled oxLDL in mice. Methods: We synthesized 123 I-oxLDL by the iodine monochloride method, and performed an uptake study in CHO cells transfected with lectin-like oxLDL receptor-1 (LOX-1). In addition, we evaluated the consistency between the 123 I-oxLDL autoradiogram and the fluorescence image of DiI-oxLDL after intravenous injection for both spleen and liver...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662562/the-predictive-values-of-lesion-size-f-18-fdg-avidity-and-i-131-avidity-for-the-clinical-outcome-of-i-131-treatment-in-patients-with-metastatic-differentiated-thyroid-carcinoma-only-in-the-lung
#5
Joon Ho Choi, Byung Hyun Byun, Ilhan Lim, Hansol Moon, Jihyun Park, Kyoung Jin Chang, Byung Il Kim, Chang Woon Choi, Sang Moo Lim
Purpose: We aimed to evaluate the prognostic values of radiography, F-18 FDG PET, and I-131 whole body scans in patients with lung-only metastasis from differentiated thyroid carcinoma (DTC). Methods: Between 1998 and 2013, we included 31 patients (F: 26, M: 5) with lung-only metastasis from DTC who had been treated with I-131 and underwent PET. Lung metastasis was categorized according to the size (macronodular ≥1.0 cm vs. micronodular <1.0 cm), FDG avidity (avid vs...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662561/a-systematic-comparative-evaluation-of-68-ga-labeled-rgd-peptides-conjugated-with-different-chelators
#6
Akanksha Jain, Sudipta Chakraborty, H D Sarma, Ashutosh Dash
Purpose: The present paper reports a systematic study on the effect of bifunctional chelators (BFC) namely, NOTA, DOTA, and DTPA, on the radiochemical formulation, in vitro stability, and in vivo biological properties of 68 Ga-labeled RGD peptide derivatives. Methods: The three RGD conjugates namely, NOTA-Bn-E-[c(RGDfk)]2 , DOTA-Bn-E-[c(RGDfk)]2 , and DTPA-Bn-E-[c(RGDfk)]2 were radiolabeled with 68 Ga and the radiolabeling was optimized with respect to the ligand amount, radiolabeling time, and temperature...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662560/impact-of-68-ga-dota-peptide-pet-ct-on-the-management-of-gastrointestinal-neuroendocrine-tumour-gi-net-malaysian-national-referral-centre-experience
#7
Teik Hin Tan, Ching Yeen Boey, Boon Nang Lee
Purpose: The National Cancer Institute is the only referral centre in Malaysia that provides 68 Ga-DOTA-peptide imaging. The purpose of this study is to determine the impact of 68 Ga-DOTA-peptide PET/CT on the management of gastrointestinal neuroendocrine tumours (GI-NET). Materials and Methods: A cross-sectional study was performed to review the impact of 68 Ga-DOTA-peptide (68 Ga-DOTATATE or 68 Ga-DOTATOC) PET/CT on patients with biopsy-proven GI-NET between January 2011 and December 2015...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662559/deep-learning-in-nuclear-medicine-and-molecular-imaging-current-perspectives-and-future-directions
#8
REVIEW
Hongyoon Choi
Recent advances in deep learning have impacted various scientific and industrial fields. Due to the rapid application of deep learning in biomedical data, molecular imaging has also started to adopt this technique. In this regard, it is expected that deep learning will potentially affect the roles of molecular imaging experts as well as clinical decision making. This review firstly offers a basic overview of deep learning particularly for image data analysis to give knowledge to nuclear medicine physicians and researchers...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662558/radiomics-as-a-quantitative-imaging-biomarker-practical-considerations-and-the-current-standpoint-in-neuro-oncologic-studies
#9
REVIEW
Ji Eun Park, Ho Sung Kim
Radiomics utilizes high-dimensional imaging data to discover the association with diagnostic, prognostic, predictive endpoint or radiogenomics. It is an emerging field of study that potentially depicts the intratumoral heterogeneity from quantitative and classified high-throughput data. The radiomics approach has an analytic pipeline where the imaging features are extracted, processed and analyzed. At this point, special data handling is essential because it faces issues of a high-dimensional biomarker compared to a single biomarker approach...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662557/ct-radiomics-in-thoracic-oncology-technique-and-clinical-applications
#10
REVIEW
Geewon Lee, So Hyeon Bak, Ho Yun Lee
Precision medicine offers better treatment options and improved survival for cancer patients based on individual variability. As the success of precision medicine depends on robust biomarkers, the requirement for improved imaging biomarkers that reflect tumor biology has grown exponentially. Radiomics, the field of study in which high-throughput data are generated and large amounts of advanced quantitative features are extracted from medical images, has shown great potential as a source of quantitative biomarkers in the field of oncology...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662556/radiomics-and-deep-learning-in-clinical-imaging-what-should-we-do
#11
EDITORIAL
Joon Young Choi
No abstract text is available yet for this article.
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662555/message-from-the-editor-in-chief-theranostic-imaging-in-2018
#12
EDITORIAL
Dong Soo Lee
No abstract text is available yet for this article.
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29393930/erratum-to-dual-pathologies-of-parathyroid-adenoma-and-papillary-thyroid-cancer-on-fluorocholine-and-fluorodeoxyglucose-pet-ct
#13
N T K Thanseer, Sanjay Kumar Bhadada, Ashwani Sood, Ashwin Singh Parihar, Divya Dahiya, Priyanka Singh, Rajender Kumar Basher, Ashim Das, Bhagwant R Mittal
[This corrects the article DOI: 10.1007/s13139-017-0488-3.].
February 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29391918/transiently-altered-distribution-of-f-18-fdg-in-a-patient-with-subacute-thyroiditis
#14
Myoung Hyoun Kim, Dae-Weung Kim, Soon-Ah Park, Chang Guhn Kim
F-18 fluorodeoxyglucose (FDG) is a highly influential radiotracer that provides valuable information in many cancer types. However, the normal biodistribution of F-18 FDG is often variable and can be altered by intrinsic or iatrogenic factors. We report a case of diffuse symmetrically increased skeletal muscle uptake and relatively decreased hepatic uptake on F-18 FDG PET/CT in a 57-year-old female with pulmonary adenocarcinoma. Detailed clinical evaluation and retrospective radiologic evaluation revealed that she had been diagnosed with subacute thyroiditis 2 weeks ago...
February 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29391917/injection-of-botulinum-toxin-for-preventing-salivary-gland-toxicity-after-psma-radioligand-therapy-an-empirical-proof-of-a-promising-concept
#15
Richard P Baum, Thomas Langbein, Aviral Singh, Mostafa Shahinfar, Christiane Schuchardt, Gerd Fabian Volk, Harshad Kulkarni
The dose-limiting salivary gland toxicity of 225 Ac-labelled PSMA for treatment of metastatic, castration-resistant prostate cancer remains unresolved. Suppressing the metabolism of the gland by intraparenchymal injections of botulinum toxin appears to be a promising method to reduce off-target uptake. A 68 Ga-PSMA PET/CT scan performed 45 days after injection of 80 units of botulinum toxin A into the right parotid gland in a 63-year-old patient showed a decrease in the SUVmean in the right parotid gland of up to 64% as compared with baseline...
February 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29391916/systemic-lupus-erythematosus-associated-pitfalls-on-18-f-fdg-pet-ct-reactive-follicular-hyperplasia-kikuchi-fujimoto-disease-inflammation-and-lymphoid-hyperplasia-of-the-spleen-mimicking-lymphoma
#16
William Makis, Anthony Ciarallo, Milene Gonzalez-Verdecia, Stephan Probst
Systemic lupus erythematosus (SLE) is associated with a variety of inflammatory processes that can affect the lymph nodes, brain, kidneys, and spleen. We present two patients with SLE in whom SLE-associated conditions complicated interpretation of 18 F-fluoro-2-deoxy-d-glucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) imaging of the lymph nodes and the spleen. The imaging findings mimicked lymphoma, but histopathological evaluation showed benign processes including reactive follicular hyperplasia in the lymph nodes, Kikuchi-Fujimoto disease in perisplenic lymph nodes, and inflammatory changes and lymphoid hyperplasia in the spleen...
February 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29391915/primary-renal-leiomyosarcoma-presenting-with-subcutaneous-and-osseous-metastases-staging-and-follow-up-with-18f-fdg-pet-ct
#17
William Makis, Fadi Brimo, Stephan Probst
A 60 year old woman who presented with multiple small subcutaneous nodules in the upper back and arms, was referred for an [18F] fluoro-2-deoxy-D-glucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) after histological evaluation revealed metastatic leiomyosarcoma of unknown origin. The PET/CT showed multiple 18 F-FDG-avid subcutaneous nodules, bone lesions, as well as a large left renal mass, which was biopsied to confirm a primary renal leiomyosarcoma arising from the renal parenchyma...
February 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29391914/multiple-regression-analysis-of-predictors-of-bone-scintigraphy-positivity-in-patients-with-head-and-neck-cancers
#18
Daris Theerakulpisut, Nantaporn Wongsurawat, Narudom Supakalin, Charoonsak Somboonporn
Purpose: The value of bone scintigraphy (BS) in patients with head and neck cancers (HNCs) has been questioned, with conflicting findings regarding positivity yield with some reports recommending BS be omitted from work-up of HNC patients since it rarely yields positive results. This study aims to determine the positivity yield of BS in HNCs and to determine predictors for BS positivity to help tailor appropriate BS utilization. Methods: BS studies of HNC patients were reviewed, the positivity yield was determined...
February 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29391913/the-utility-of-fdg-pet-ct-in-igg4-related-disease-with-a-focus-on-coronary-artery-involvement
#19
Hian L Huang, Warren Fong, Wee M Peh, Kasat A Niraj, Winnie W Lam
Purpose: Our case series aims to study the growing use of FDG PET/CT in diagnostic evaluation and follow up of IgG4-RD with emphasis on patients presenting with coronary artery involvement. Methods: We conducted a search on the nuclear medicine and rheumatology service databases and identified patients with histologically proven IgG4-RD with FDG PET/CT performed at the Singapore General Hospital. The radiological, clinical, and laboratory findings of these patients were analyzed retrospectively...
February 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29391912/correlation-of-fdg-pet-ct-findings-with-long-term-growth-and-clinical-course-of-abdominal-aortic-aneurysm
#20
Hyunjong Lee, Jin Chul Paeng, Kyung Hwan Kim, Gi Jeong Cheon, Dong Soo Lee, June-Key Chung, Keon Wook Kang
Purpose: Herein, we report characteristics of 18 F-fluorodeoxyglucose (FDG) uptake in abdominal aortic aneurysms (AAAs) during a long-term follow-up. In addition, we investigated the association between FDG uptake and the physician decision to perform an intervention. Methods: We performed a retrospective review of 42 patients with AAAs who underwent FDG positron emission tomography (PET)/computed tomography (CT). The size of the AAA was measured in serial CT or PET/CT images...
February 2018: Nuclear Medicine and Molecular Imaging
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