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Nuclear Medicine and Molecular Imaging

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https://www.readbyqxmd.com/read/28250865/scintigraphic-evidence-for-overdiagnosis-of-small-pe-on-ct-pulmonary-angiography
#1
Yang Lu
A 68-year-old man with recent history of a fall presented with dyspnea on exertion, and underwent computed tomography pulmonary angiography (CTPA) for possible pulmonary embolism (PE). The CTPA was first read by the radiology resident as nondiagnostic for segmental PE. Subsequent planar perfusion (Q) images were normal; meanwhile, the attending radiologist revised the CTPA results as subsegmental PE in the left upper lobe. Further Q-SPECT images were obtained and fused with CTPA for clarification, which showed normal perfusion in the region of PE...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250864/unusual-horner-s-syndrome-in-recurrent-breast-cancer-evaluation-using-18-f-fdg-pet-ct
#2
Sohyun Park, Tae Sung Kim, Seok-Ki Kim
(18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a widely used imaging modality in the initial diagnosis of cancer, treatment response evaluation and detection of recurrence. Herein, we present the case of a 39-year-old female who presented right ptosis on the follow-up of breast cancer after surgery. Clinicians suspected Horner's syndrome, and the patient underwent FDG PET/CT for the evaluation of recurrence that could cause Horner's syndrome. FDG PET/CT demonstrated a focal hypermetabolic lesion in the right cervicothoracic junction area, corresponding to the preganglionic cervical sympathetic trunk...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250863/primary-pulmonary-lymphoepithelioma-like-carcinoma-on-fdg-pet-ct
#3
Gul Ege Aktas, Nuray Can, Selin Soyluoglu Demir, Ali Sarıkaya
A 69-year-old male smoker was referred to (18)F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) with the indication of a suspicious solitary pulmonary nodule. FDG PET/CT determined a 2.5 × 2-cm soft-tissue lesion (SUVmax, 16.2) with spiculated margins in the hilum of the right lung. A 1-cm diameter lymphadenopathy on the right hilum with an SUVmax of 3.2 was also determined. Transbronchial biopsy of the right hilar lymphadenopathy did not reveal any malignant features in histopathologic examination, and it was determined to be reactive...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250862/fdg-pet-identification-of-infected-pulmonary-artery-conduit-following-tetralogy-of-fallot-tof-repair
#4
Yuyang Zhang, Hadyn Williams, Darko Pucar
Tetralogy of Fallot (TOF) is one of the most common forms of cyanotic congenital heart disease usually managed by serial surgical repairs. The repaired prosthetic valve or conduit is susceptible to life-threatening infection. FDG-PET is an effective alternative to evaluate the source of infection when other examinations are inconclusive. We report an unusual case of an infected pulmonary artery conduit after TOF repair although the echocardiogram was negative for vegetation, which was later confirmed by surgery and pathology...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250861/correlation-of-molecular-subtypes-of-invasive-ductal-carcinoma-of-breast-with-glucose-metabolism-in-fdg-pet-ct-based-on-the-recommendations-of-the-st-gallen-consensus-meeting-2013
#5
Sun Seong Lee, Sang Kyun Bae, Yun Soo Park, Ji Sun Park, Tae Hyun Kim, Hye Kyoung Yoon, Hyo Jung Ahn, Seok Mo Lee
PURPOSE: This study aimed to investigate the relationship between the SUVmax of primary breast cancer lesions and the molecular subtypes based on the recommendations of the St. Gallen consensus meeting 2013. METHODS: Clinical records of patients who underwent F-18 FDG PET/CT for initial staging of invasive ductal carcinoma (IDC) of the breast were reviewed. A total of 183 patients were included. SUVmax was correlated with the molecular subtypes defined by the St...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250860/the-role-of-f-18-fdg-pet-ct-in-intrahepatic-cholangiocarcinoma
#6
Yeongjoo Lee, Ie Ryung Yoo, Sun Ha Boo, Hyoungwoo Kim, Hye Lim Park, Joo Hyun O
PURPOSE: The aim of this study was to evaluate the diagnostic and prognostic role of metabolic parameters of FDG PET/CT in patients with intrahepatic cholangiocarcinoma (ICC). METHODS: From December 2008 to December 2013, 76 FDG PET/CT scans performed for initial staging of ICC in a single institution (57 male and 19 female; mean age 68 ± 9 years) were retrospectively reviewed. Patients with history of other known malignancy were excluded. Detection rates of regional lymph node and distant metastasis by FDG PET/CT were analyzed in comparison with conventional imaging modalities such as CT or MRI...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250859/-18-f-fdg-pet-ct-for-the-diagnosis-of-malignant-and-infectious-complications-after-solid-organ-transplantation
#7
Nastassja Muller, Romain Kessler, Sophie Caillard, Eric Epailly, Fabrice Hubelé, Céline Heimburger, Izzie-Jacques Namer, Raoul Herbrecht, Cyrille Blondet, Alessio Imperiale
PURPOSE: Infection and malignancy represent two common complications after solid organ transplantation, which are often characterized by poorly specific clinical symptomatology. Herein, we have evaluated the role of (18)F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) in this clinical setting. METHODS: Fifty-eight consecutive patients who underwent FDG PET/CT after kidney, lung or heart transplantation were included in this retrospective analysis...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250858/risk-stratification-for-avascular-necrosis-of-the-femoral-head-after-internal-fixation-of-femoral-neck-fractures-by-post-operative-bone-spect-ct
#8
Sangwon Han, Minyoung Oh, Seokho Yoon, Jinsoo Kim, Ji-Wan Kim, Jae-Suk Chang, Jin-Sook Ryu
PURPOSE: Avascular necrosis (AVN) of the femoral head is a major complication after internal fixation of a femoral neck fracture and determines the functional prognosis. We investigated postoperative bone single-photon emission computed tomography/computed tomography (SPECT/CT) for assessing the risk of femoral head AVN. METHODS: We retrospectively reviewed 53 consecutive patients who underwent bone SPECT/CT within 2 weeks of internal fixation of a femoral neck fracture and follow-up serial hip radiographs over at least 12 months...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250857/comparative-analysis-of-99m-tc-mdp-three-phase-bone-scan-with-spect-ct-and-99m-tc-hmpao-labeled-wbc-spect-ct-in-the-differential-diagnosis-of-clinically-suspicious-post-traumatic-osteomyelitis
#9
Chanwoo Kim, Soo Jin Lee, Ji Young Kim, Kyu Tae Hwang, Yun Young Choi
PURPOSE: To identify differences between three-phase bone scan and SPECT/CT (TBS) and WBC SPECT/CT (WS) and compare diagnostic accuracies of each modality in patients with suspicious post-traumatic osteomyelitis (OM). METHODS: Twenty-one patients with suspicious post-traumatic OM were enrolled. All patients performed TBS and WS within 1 week. Foci of MDP and WBC accumulation were divided into three categories: bone (OM), soft tissue (soft tissue inflammation; STI), negative for inflammation (NI)...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250856/usefulness-of-spect-ct-in-parathyroid-lesion-detection-in-patients-with-thyroid-parenchymal-99m-tc-sestamibi-retention
#10
Sang Hyun Hwang, Yumie Rhee, Mijin Yun, Jung Hyun Yoon, Jeong Won Lee, Arthur Cho
PURPOSE: Parathyroid adenoma detection with dual-phase (99m)Tc-sestamibi (MIBI) scintigraphy depends on differential MIBI washout from thyroid. However, autoimmune thyroid disease (AITD) may cause MIBI to be retained in the thyroid gland and reduce parathyroid detection. We evaluated the impact of AITD on MIBI thyroid retention and additional benefit of SPECT/CT in these patients. METHODS: Dual phase planar MIBI and SPECT/CT was performed on 82 patients. SPECT/CT was performed immediately after delayed planar scan...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250855/fdg-whole-body-pet-mri-in-oncology-a-systematic-review
#11
REVIEW
Hyun Woo Kwon, Ann-Katharina Becker, Jin Mo Goo, Gi Jeong Cheon
The recent advance in hybrid imaging techniques enables offering simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) in various clinical fields. (18)F-fluorodeoxyglucose (FDG) PET has been widely used for diagnosis and evaluation of oncologic patients. The growing evidence from research and clinical experiences demonstrated that PET/MRI with FDG can provide comparable or superior diagnostic performance more than conventional radiological imaging such as computed tomography (CT), MRI or PET/CT in various cancers...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250854/radio-graphene-in-theranostic-perspectives
#12
REVIEW
Do Won Hwang
Owing to its unique physicochemical properties such as high surface area, notable biocompatibility, robust mechanical strength, high thermal conductivity, and ease of functionalization, 2D-layered graphene has received tremendous attention as a futuristic nanomaterial and its-associated research has been rapidly evolving in a variety of fields. With the remarkable advances of graphene especially in the biomedical realm, in vivo evaluation techniques to examine in vivo behavior of graphene are largely demanded under the hope of clinical translation...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250853/radiation-safety-in-nuclear-medicine-procedures
#13
REVIEW
Sang-Geon Cho, Jahae Kim, Ho-Chun Song
Since the nuclear disaster at the Fukushima Daiichi Nuclear Power Plant in 2011, radiation safety has become an important issue in nuclear medicine. Many structured guidelines or recommendations of various academic societies or international campaigns demonstrate important issues of radiation safety in nuclear medicine procedures. There are ongoing efforts to fulfill the basic principles of radiation protection in daily nuclear medicine practice. This article reviews important principles of radiation protection in nuclear medicine procedures...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250852/pet-imaging-based-phenotyping-as-a-predictive-biomarker-of-response-to-tyrosine-kinase-inhibitor-therapy-in-non-small-cell-lung-cancer-are-we-there-yet
#14
Victor H Gerbaudo, Chun K Kim
The increased understanding of the molecular pathology of different malignancies, especially lung cancer, has directed investigational efforts to center on the identification of different molecular targets and on the development of targeted therapies against these targets. A good representative is the epidermal growth factor receptor (EGFR); a major driver of non-small cell lung cancer tumorigenesis. Today, tumor growth inhibition is possible after treating lung tumors expressing somatic mutations of the EGFR gene with tyrosine kinase inhibitors (TKI)...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28250851/message-from-the-editor-in-chief-2017
#15
EDITORIAL
Dong Soo Lee
No abstract text is available yet for this article.
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27994694/-99m-tc-mibi-uptake-in-a-thyroid-adenoma-with-diffuse-adipose-metaplasia
#16
Gaetano Paone, Luca Mazzucchelli, Giuseppe Peloni, Fabrizio Fasolini, Luca Giovanella
A 71-year-old female underwent a (99m)Tc-MIBI scan to characterize a cold nodule (30 mm) of the left thyroid lobe. The nodule showed diffuse uptake and retention of the radiotracer. After resection, histological examination demonstrated a microfollicular adenoma with diffuse white adipose metaplasia. Although mitochondria in brown adipose tissue have been widely studied, we have only a limited understanding of the relevance of mitochondria in white adipose tissue. Active mitochondria are present in white adipocytes, and this may account for the MIBI uptake, mimicking a hyperproliferation pattern, in our patient(...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27994693/systemic-immune-response-to-vaccination-on-fdg-pet-ct
#17
Mark Mingos, Stephanie Howard, Nicholas Giacalone, David Kozono, Heather Jacene
A patient with newly diagnosed right lung cancer had transient (18)F-fluorodeoxyglucose (FDG)-avid left axillary lymph nodes and intense splenic FDG uptake on positron emission tomography (PET)/computed tomography (CT). History revealed that the patient received a left-sided influenza vaccine 2-3 days before the examination. Although inflammatory FDG uptake in ipsilateral axillary nodes is reported, to our knowledge, this is the first report of visualization of the systemic immune response in the spleen related to the influenza vaccination on FDG-PET/CT...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27994692/incidental-findings-of-intense-radioiodine-uptake-in-struma-ovarii-and-bilateral-nonlactating-breasts-simultaneously-on-postablation-131-i-spect-ct-for-papillary-thyroid-cancer
#18
Hye-Kyung Shim, Mi Ra Kim
A 52-year-old woman diagnosed with papillary thyroid carcinoma was referred for (131)I therapy following total thyroidectomy. She was given 4,810 MBq (130 mCi) of (131)I following 4 weeks of thyroid hormone withdrawal. A posttherapy scan showed intense, focal activity in the pelvis and intense, diffuse activity on both sides of the chest, which was localized to the right ovary and both breasts on SPECT/CT examination. She had bilateral nipple pain and a history of antidopaminergic drugs as combination medication for her rheumatoid arthritis and prokinetics during radioiodine therapy...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27994691/giant-cell-tumor-with-secondary-aneurysmal-bone-cyst-shows-heterogeneous-metabolic-pattern-on-18-f-fdg-pet-ct-a-case-report
#19
Hee Jeong Park, Seong Young Kwon, Sang-Geon Cho, Jahae Kim, Ho-Chun Song, Sung Sun Kim, Yeon Hong Yoon, Jin Gyoon Park
Giant cell tumor (GCT) is a generally benign bone tumor accounting for approximately 5 % of all primary bone neoplasms. Cystic components in GCTs that indicate secondary aneurysmal bone cysts (ABCs) are reported in 14 % of GCTs. Although both of them have been described separately in previous reports that may show considerable fluorodeoxyglucose (FDG) uptake despite their benign nature, the findings of GCT with secondary ABC on (18)F-FDG positron emission tomography/computed tomography (PET/CT) have not been well-known...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27994690/unusual-uptake-of-prostate-specific-tracer-68-ga-psma-hbed-cc-in-a-benign-thyroid-nodule
#20
Nishikant Avinash Damle, Madhavi Tripathi, Partha Sarathi Chakraborty, Manas Kumar Sahoo, Chandrasekhar Bal, Shipra Aggarwal, Geetanjali Arora, Praveen Kumar, Rajeev Kumar, Ravikant Gupta
(68)Ga-Prostate specific membrane antigen- N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/CT in the initial staging in PC is uncertain at this time. Clinical studies are underway to define its exact role in the management of the disease...
December 2016: Nuclear Medicine and Molecular Imaging
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