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International Journal for Numerical Methods in Biomedical Engineering

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https://www.readbyqxmd.com/read/28523829/the-prediction-of-viscous-losses-and-pressure-drop-in-models-of-the-human-airways
#1
A K Wells, I P Jones, S Hamill, R Bordas
This paper examines the viscous flow resistance in branching tubes as applied to simplified models of the lungs, and compares the results of Computational Fluid Dynamics (CFD) simulations for a range of conditions with measurement data. The results are in good agreement with the available measurement data for both inspiration and expiration. A detailed sensitivity analysis of the dissipation and viscous resistance in a branch then examines the ratio of the viscous resistance to that for a fully developed Poiseuille flow, Z...
May 18, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28521384/analysis-of-tenodesis-techiques-for-treatment-of-scapholunate-instability-using-the-finite-element-method
#2
Teresa Alonso Rasgado, Qinghang Zhang, David Jimenez Cruz, Colin Bailey, Elizabeth Pinder, Avanthi Mandaleson, Sumedh Talwalkar
Chronic Scapholunate ligament (SL) injuries are difficult to treat and can lead to wrist dysfunction. Whilst several tendon reconstruction techniques have been employed in the management of SL instability, SL gap reappearance after surgery has been reported. Using finite element model and cadaveric study data we investigated the performance of the Corella, schapolunate axis (SLAM) and modified Brunelli tenodesis (MBT) techniques. Virtual tenodesis surgery was undertaken in 3D finite element (FE) models to obtain the scapholunate (SL) gap and angle resulting from the three reconstruction techniques...
May 18, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28474497/uncertainty-quantification-of-two-models-of-cardiac-electromechanics
#3
Daniel E Hurtado, Sebastián Castro, Pedro Madrid
Computational models of the heart have reached a maturity level that render them useful for in-silico studies of arrhythmia and other cardiac diseases. However, the translation to the clinic of cardiac simulations critically depends on demonstrating the accuracy, robustness and reliability of the underlying computational models under the presence of uncertainties. In this work, we study for the first time the effect of parameter uncertainty on two state-of-the-art coupled models of excitation-contraction of cardiac tissue...
May 4, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28474382/the-role-of-angled-tip-microcatheter-and-microsphere-injection-velocity-in-liver-radioembolization-a-computational-particle-hemodynamics-study
#4
Jorge Aramburu, Raúl Anton, Alejandro Rivas, Juan Carlos Ramos, Bruno Sangro, José Ignacio Bilbao
Liver radioembolization is a promising treatment option for combating liver tumors. It is performed by placing a microcatheter in the hepatic artery and administering radiation-emitting microspheres through the arterial bloodstream so that they get lodged in the tumoral bed. In avoiding nontarget radiation, the standard practice is to conduct a pretreatment, in which the microcatheter location and injection velocity are decided. However, between pretreatment and actual treatment some of the parameters that influence the particle distribution in the liver can vary, resulting in radiation-induced complications...
May 4, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28447404/potential-biomechanical-roles-of-risk-factors-in-the-evolution-of-thrombus-laden-abdominal-aortic-aneurysms
#5
Lana Virag, John S Wilson, Jay D Humphrey, Igor Karšaj
Abdominal aortic aneurysms (AAAs) typically harbour an intraluminal thrombus (ILT), yet most prior computational models neglect biochemomechanical effects of thrombus on lesion evolution. We recently proposed a growth and remodelling model of thrombus-laden AAAs that introduced a number of new constitutive relations and associated model parameters. Because values of several of these parameters have yet to be elucidated by clinical data, and could vary significantly from patient to patient, the aim of this study was to investigate the possible extent to which these parameters influence AAA evolution...
April 26, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28445003/a-multiscale-approach-for-determining-the-morphology-of-endothelial-cells-at-a-coronary-artery
#6
Hossein Ali Pakravan, Mohammad Said Saidi, Bahar Firoozabadi
The morphology of endothelial cells (ECs) may be an indication for determining the atheroprone sites. Until now, there is not any clinical imaging technique to visualize the morphology of ECs at the arteries. The present study, introduces a computational technique for determining the morphology of ECs. This technique is a multiscale simulation, consisting the artery-scale and the cell-scale. The artery-scale is a FSI simulation. The input for the artery-scale is the geometry of the coronary artery (CA), dynamic curvature of the artery due to the cardiac motion, blood flow, blood pressure, heart rate, and the mechanical properties of the blood and the arterial wall, which these quantities can be obtained for a specific patient...
April 26, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28444997/a-holistic-view-of-the-effects-of-episiotomy-on-pelvic-floor
#7
Dulce A Oliveira, Marco P L Parente, Begoña Calvo, Teresa Mascarenhas, Renato M Natal Jorge
Vaginal delivery is commonly accepted as a risk factor in pelvic floor dysfunction (PFD), however, other obstetric procedures (episiotomy) are still controversial. In this work, to analyze the relationship between episiotomy and pelvic floor function, a finite element model (FEM) of the pelvic cavity is used considering the pelvic floor muscles (PFM) with damaged regions from spontaneous vaginal delivery, and from deliveries with episiotomy. Common features assessed at screening of PFD are evaluated during numerical simulations of both Valsalva maneuver and contraction...
April 26, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28425587/hybrid-finite-difference-finite-element-immersed-boundary-method
#8
Boyce E Griffith, Xiaoyu Luo
The immersed boundary method is an approach to fluid-structure interaction that uses a Lagrangian description of the structural deformations, stresses, and forces along with an Eulerian description of the momentum, viscosity, and incompressibility of the fluid-structure system. The original immersed boundary methods described immersed elastic structures using systems of flexible fibers, and even now, most immersed boundary methods still require Lagrangian meshes that are finer than the Eulerian grid. This work introduces a coupling scheme for the immersed boundary method to link the Lagrangian and Eulerian variables that facilitates independent spatial discretizations for the structure and background grid...
April 20, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28425209/identification-of-dynamic-load-for-prosthetic-structures
#9
Dequan Zhang, Xu Han, Zhongpu Zhang, Jie Liu, Chao Jiang, Nobuhiro Yoda, Xianghua Meng, Qing Li
Dynamic load exists in numerous biomechanical systems and its identification signifies a critical issue for characterizing dynamic behaviors and studying biomechanical consequence of the systems. This study aims to identify dynamic load in the dental prosthetic structures, namely three-unit implant-supported fixed partial denture (I-FPD) and teeth-supported fixed partial denture (T-FPD). The three-dimensional (3D) finite element (FE) models were constructed through patient's computerized tomography (CT) images...
April 20, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28425201/numerical-analysis-of-crimping-and-inflation-process-of-balloon-expandable-coronary-stent-using-implicit-solution
#10
Jakub Bukala, Piotr Kwiatkowski, Jerzy Malachowski
The paper presents an applied methodology for numerical Finite Element analysis of coronary stent crimping and the free inflation process with the use of a folded non-compliant angioplasty balloon. The use of an implicit scheme is considered as the most original part of the work, as an explicit finite element procedure is very often preferred. Hitherto, when the implicit solution was used for the Finite Element solution, the simulated issue was largely simplified. Therefore, the authors focused on the modelling methodology with minimum possible simplification, i...
April 20, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28388837/effective-sparse-representation-of-x-ray-medical-images
#11
Laura Rebollo-Neira
Effective sparse representation of X-Ray medical images within the context of data reduction is considered. The proposed framework is shown to render an enormous reduction in the cardinality of the data set required to represent this class of images at very good quality. The goal is achieved by a) creating a dictionary of suitable elements for the image decomposition in the wavelet domain and b) applying effective greedy strategies for selecting the particular elements which enable the sparse decomposition of the wavelet coefficients...
April 7, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28349647/finite-element-modeling-validation-and-parametric-investigations-of-a-retinal-reattachment-stent
#12
Razvan Rusovici, Dennis Dalli, Kunal Mitra, Gary Ganiban, Michael Grace, Rudy Mazzocchi, Michael Calhoun
A new retinal reattachment surgical procedure is based on a stent which is deployed to press the retina back in place. An eye-stent finite element model studied the strain induced by the stent on retina. FEM simulations were performed for several stent geometric configurations (number of loops, wire diameter, intraocular pressure). The FEM was validated against experiment. Parametric studies demonstrated that stents could be successfully designed so that the maximum strain would be below permanent damage strain threshold of 2%...
March 27, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28337862/bayesian-sensitivity-analysis-of-a-1d-vascular-model-with-gaussian-process-emulators
#13
Alessandro Melis, Richard H Clayton, Alberto Marzo
One-dimensional models of the cardiovascular system can capture the physics of pulse waves but involve many parameters. Since these may vary among individuals, patient-specific models are difficult to construct. Sensitivity analysis can be used to rank model parameters by their effect on outputs and to quantify how uncertainty in parameters influences output uncertainty. This type of analysis is often conducted with a Monte Carlo method, where large numbers of model runs are used to assess input-output relations...
March 24, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28329435/face-shield-design-against-blast-induced-head-injuries
#14
Long Bin Tan, Kwong Ming Tse, Yuan Hong Tan, Mohamad Ali Bin Sapingi, Vincent Beng Chye Tan, Heow Pueh Lee
Blast-induced traumatic brain injury (TBI) has been on the rise in recent years due to the increasing use of improvised explosive devices (IEDs) in conflict zones. Our study investigates the response of a helmeted human head subjected to a blast of 1 atm peak overpressure, for cases with and without a standard polycarbonate (PC) face shield and for face shields comprising of composite PC and aerogel materials and with lateral edge extension. The novel introduction of aerogel into the laminate face shield is explored and its wave-structure interaction mechanics and performance in blast mitigation is analysed...
March 22, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28294580/effect-of-cerebrospinal-fluid-modeling-on-spherically-convergent-shear-waves-during-blunt-head-trauma
#15
Amit Madhukar, Ying Chen, Martin Ostoja-Starzewski
The MRI-based computational model, previously validated by tagged MRI and harmonic phase imaging analysis technique on in vivo human brain deformation, is used to study transient wave dynamics during blunt head trauma. Three different constitutive models are used for the cerebrospinal fluid: incompressible solid elastic, viscoelastic, and fluid-like elastic using an equation of state model. Three impact cases are simulated, which indicate that the blunt impacts give rise not only to a fast pressure wave but also to a slow, and potentially much more damaging, shear (distortional) wave that converges spherically towards the brain center...
March 14, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28294574/phase-field-boundary-conditions-for-the-voxel-finite-cell-method-surface-free-stress-analysis-of-ct-based-bone-structures
#16
L H Nguyen, S K F Stoter, T Baum, J S Kirschke, M Ruess, Z Yosibash, D Schillinger
The voxel finite cell method employs unfitted finite element meshes and voxel quadrature rules to seamlessly transfer CT data into patient-specific bone discretizations. The method, however, still requires the explicit parametrization of boundary surfaces to impose traction and displacement boundary conditions, which constitutes a potential roadblock to automation. We explore a phase-field based formulation for imposing traction and displacement constraints in a diffuse sense. Its essential component is a diffuse geometry model generated from metastable phase-field solutions of the Allen-Cahn problem that assumes the imaging data as initial condition...
March 11, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28268244/calculation-of-cancellous-bone-elastic-properties-with-the-polarization-based-fft-iterative-scheme
#17
Lucas Colabella, Ariel Alejandro Ibarra Pino, Josefina Ballarre, Piotr Kowalczyk, Adrián Pablo Cisilino
The FFT based method, originally introduced by Moulinec and Suquet in 1994 has gained popularity for computing homogenized properties of composites. In this work, the method is used for the computational homogenization of the elastic properties of cancellous bone. To the authors' knowledge, this is the first study where the FFT scheme is applied to bone mechanics. The performance of the method is analyzed for artificial and natural bone samples of two species: bovine femoral heads and implanted femurs of Hokkaido rats...
March 7, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28264145/human-body-modeling-method-to-simulate-the-biodynamic-characteristics-of-spine-in-vivo-with-different-sitting-postures
#18
Rui-Chun Dong, Li-Xin Guo
The aim of this study is to model the computational model of seated whole human body including skeleton, muscle, viscera, ligament, intervertebral disc, and skin to predict effect of the factors (sitting postures, muscle and skin, buttocks, viscera, arms, gravity, and boundary conditions) on the biodynamic characteristics of spine. Two finite element models of seated whole body and a large number of finite element models of different ligamentous motion segments were developed and validated. Static, modal, and transient dynamic analyses were performed...
March 6, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28257608/research-and-primary-evaluation-of-an-automatic-fusion-method-for-multisource-tooth-crown-data
#19
Ning Dai, Dawei Li, Xu Yang, Cheng Cheng, Yuchun Sun
With the development of 3-dimensional (3D) scanning technologies in dentistry, high accuracy optical scanning data from the crown and cone beam computed tomography data from the root can be acquired easily. In many dental fields, especially in digital orthodontics, it is useful to fuse the data from the crown and the root. However, the manual fusion method is complex and difficult. A novel automatic fusion method for 2-source data from the crown and the root was researched, and its accuracy was evaluated in this study...
March 3, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28249103/a-hybrid-computational-model-to-explore-the-topological-characteristics-of-epithelial-tissues
#20
Ismael González-Valverde, José Manuel García Aznar
Epithelial tissues show a particular topology where cells resemble a polygon-like shape, but some biological processes can alter this tissue topology. During cell proliferation, mitotic cell dilation deforms the tissue and modifies the tissue topology. Additionally, cells are reorganized in the epithelial layer and these rearrangements also alter the polygon distribution. We present here a computer-based hybrid framework focused on the simulation of epithelial layer dynamics that combines discrete and continuum numerical models...
March 1, 2017: International Journal for Numerical Methods in Biomedical Engineering
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