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International Journal for Numerical Methods in Biomedical Engineering

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https://www.readbyqxmd.com/read/29968373/nasal-surgery-handled-by-cfd-tools
#1
E Sanmiguel-Rojas, M A Burgos, F Esteban-Ortega
Annually, hundreds of thousands of surgical interventions to correct nasal airway obstruction are performed throughout the world. Recent studies have noted that a significant number of patients have persistent symptoms of nasal obstruction postoperatively. In the present work, we introduce a new methodology that raises the success rate of nasal cavity surgery. In this procedure, the surgeon performs virtual surgery on a 3-D nasal model of a patient prior to the real surgery. The main goal of the methodology is to guide the surgeon throughout the virtual operation using mathematical estimators based on CFD results...
July 2, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29968364/1d-3d-multi-scale-computational-modeling-for-cerebral-blood-flow-with-aneurysms-and-or-stenoses
#2
Hongtao Yu, George P Huang, Zifeng Yang, Bryan R Ludwig
A 1D-3D multi-scale model for the human vascular network was proposed by combining a low-fidelity one-dimensional (1D) modeling of blood circulation to account for the global hemodynamics with a detailed three-dimensional (3D) simulation of a zonal vascular segment. The coupling approach involves a direct exchange of flow and pressure information at interfaces between the 1D and 3D models and thus enables patient-specific morphological models to be inserted into flow network with minimum computational efforts...
July 2, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29959827/coordinate-transformation-aided-finite-element-method-for-contour-detection-of-breast-tumors-in-microwave-imaging
#3
Ozlem Ozgun, Mustafa Kuzuoglu
A coordinate transformation based finite element method (called CT-FEM) is presented for detecting contours of breast cancer tissues in the context of microwave imaging. The geometry and location of a single or multiple cancerous tumors inside a breast tissue are identified by constructing an inverse problem based on the genetic optimization algorithm. The expensive forward solution phase during repeated cost function evaluations is accelerated by placing a transformation medium inside the finite element mesh...
June 29, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29956892/surrogate-based-visualization-and-sensitivity-analysis-of-coronary-stent-performance-a-study-on-the-influence-of-geometric-design
#4
Nelson S Ribeiro, João Folgado, Hélder C Rodrigues
The main goal of this numerical study is to assess the impact of geometric design perturbations on the performance of a representative coronary stent platform. In this context, first, a design parameterization model was defined for the stent under study. After, a set of metrics characterizing stent performance, namely vessel injury, radial recoil, bending resistance, longitudinal resistance, radial strength, the risk of fracture, prolapse index, and dogboning were evaluated within the context of a finite element analysis...
June 29, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29947132/a-multi-scale-model-of-the-coronary-circulation-applied-to-investigate-transmural-myocardial-flow
#5
Xinyang Ge, Zhaofang Yin, Yuqi Fan, Yuri Vassilevski, Fuyou Liang
Distribution of blood flow in myocardium is a key determinant of the localization and severity of myocardial ischemia under impaired coronary perfusion conditions. Previous studies have extensively demonstrated the transmural difference of ischemic vulnerability. However, it remains incompletely understood how transmural myocardial flow is regulated under in vivo conditions. In the present study, a computational model of the coronary circulation was developed to quantitatively evaluate the sensitivity of transmural flow distribution to various cardiovascular and hemodynamic factors...
June 27, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29939493/a-three-dimensional-3d-two-way-coupled-fluid-structure-interaction-fsi-study-of-peristaltic-flow-in-obstructed-ureters
#6
Ahmed Tasnub Takaddus, Abhilash J Chandy
Obstruction in the ureter flow path is one of the most common problems in urinary related diseases. As the ureter transports the urine using the expansion bolus created by the peristaltic pulses, an obstruction in its path can cause unwanted backflow and can also result in damage to the wall. But in order to understand this further, and specifically to quantify and parametrise the effect of the obstruction in the ureter, a detailed study investigating various level of obstructions in peristaltic ureter flow is necessary...
June 25, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29935057/on-the-use-of-machine-learning-techniques-for-the-mechanical-characterization-of-soft-biological-tissues
#7
M Cilla, I Pérez-Rey, M A Martínez, Estefania Peña, Javier Martínez
Motivated by the search for new strategies for fitting a material model, a new approach is explored in the present work. The use of numerical and complex algorithms based on machine learning techniques such as support vector machines for regression, bagged decision trees and artificial neural networks is proposed for solving the parameter identification of constitutive laws for soft biological tissues. First, the mathematical tools were trained with analytical uniaxial data (circumferential and longitudinal directions) as inputs, and their corresponding material parameters of the Gasser, Ogden and Holzapfel strain energy function as outputs...
June 23, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29932495/influence-of-ageing-on-human-body-blood-flow-and-heat-transfer-a-detailed-computational-modelling-study
#8
Alberto Coccarelli, Hayder Hasan, Jason Carson, Dimitris Parthimos, Perumal Nithiarasu
Ageing plays a fundamental role in arterial blood transport and heat transfer within a human body. The aim of this work is to provide a comprehensive methodology, based on biomechanical considerations, for modelling arterial flow and energy exchange mechanisms in the body accounting for age-induced changes. The study outlines a framework for age-related modifications within several interlinked subsystems, which include: arterial stiffening, heart contractility variations, tissue volume and property changes, and thermoregulatory system deterioration...
June 22, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29927092/0d-lumped-approach-to-incorporate-the-dynamic-part-of-the-pressure-at-vessel-junctions-in-a-1d-wave-propagation-model
#9
T van den Boom, R R F Stevens, T Delhaas, F N van de Vosse, W Huberts
A benchmark study by Boileau et al. tested six commonly used numerical schemes for 1D wave propagation, for their ability to capture the main features of pressure, flow, and area waveforms in large arteries. While all numerical schemes showed good agreement in pressure and flow waveforms for smaller arterial networks, the Simplified Trapezium-rule Method proposed by Kroon et al. showed an overestimation for the systolic pressure of 1% in proximal regions and an underestimation of 3% in distal regions in comparison with the five other schemes when using a larger arterial network, published as the ADAN56 model...
June 21, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29908048/effects-of-nerve-bundle-geometry-on-neurotrauma-evaluation
#10
Ilaria Cinelli, Michel Destrade, Peter McHugh, Maeve Duffy
OBJECTIVE: We confirm that alteration of a neuron structure can induce abnormalities in signal propagation for nervous systems, as observed in brain damage. Here, we investigate the effects of geometrical changes and damage of a neuron structure in two scaled nerve bundle models, made of myelinated nerve fibres or unmyelinated nerve fibres. METHODS: We propose a 3D finite element model of nerve bundles, combining a real-time full electro-mechanical coupling, a modulated threshold for spiking activation and independent alteration of the electrical properties for each fibre...
June 16, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29905015/investigation-of-raphe-function-in-the-bicuspid-aortic-valve-and-its-influence-on-clinical-criteria-a-patient-specific-finite-element-study
#11
Jérémy Dallard, Michel R Labrosse, Benjamin Sohmer, Carsten J Beller, Munir Boodhwani
The aortic valve is normally composed of three cusps. In one common lesion, two cusps are fused together. The conjoined area of the fused cusps is termed raphe. Occurring in 1-2% of the population, the bicuspid aortic valve (BAV) is the most common congenital cardiac malformation. The majority of BAV patients eventually require surgery. There is a lack in the literature regarding modeling of the raphe (geometry and material properties), its role and its influence on BAV function. The present study aims to propose improvements on these aspects...
June 14, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29892995/evaluating-the-roles-of-detailed-endocardial-structures-on-right-ventricular-haemodynamics-by-means-of-cfd-simulations
#12
Federica Sacco, Bruno Paun, Oriol Lehmkuhl, Tinen L Iles, Paul A Iaizzo, Guillaume Houzeaux, Mariano Vázquez, Constantine Butakoff, Jazmin Aguado-Sierra
Computational modelling plays an important role in right ventricular (RV) haemodynamic analysis. However, current approaches employ smoothed ventricular anatomies. The aim of this study is to characterise RV haemodynamics including detailed endocardial structures like trabeculae, moderator band and papillary muscles (PMs). Four paired detailed and smoothed RV endocardium models (two male and two female) were reconstructed from ex-vivo human hearts high-resolution magnetic resonance images (MRI). Detailed models include structures with ≥1 mm2 cross-sectional area...
June 11, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29883060/nonstandard-finite-difference-approach-for-solving-three-compartment-pharmacokinetic-models
#13
Oluwaseun Francis Egbelowo
Complex nature of the analytical solutions to three-compartment pharmacokinetic models lead to the discrete approximation of the continuous differential equation been mostly used. In this paper, we applied nonstandard finite difference (NSFD) method to three-compartment pharmacokinetic models. This method was introduced to compensate for the weaknesses of methods such as the standard finite difference (SFD) methods; numerical instabilities being a prime example of such. Three-compartment pharmacokinetic model with two different routes of administration (I...
June 8, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29858530/modeling-hemodynamics-in-intracranial-aneurysms-comparing-accuracy-of-cfd-solvers-based-on-finite-element-and-finite-volume-schemes
#14
Lorenzo Botti, Nikhil Paliwal, Pierangelo Conti, Luca Antiga, Hui Meng
Image-based computational fluid dynamics (CFD) has shown potential to aid in the clinical management of intracranial aneurysms (IAs) but its adoption in the clinical practice has been missing, partially due to lack of accuracy assessment and sensitivity analysis. To numerically solve the flow-governing equations CFD solvers generally rely on two spatial discretization schemes: Finite Volume (FV) and Finite Element (FE). Since increasingly accurate numerical solutions are obtained by different means, accuracies and computational costs of FV and FE formulations cannot be compared directly...
June 1, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29856119/effect-of-upper-airway-on-tracheobronchial-fluid-dynamics
#15
Minsuok Kim, Guilhem J Collier, Jim M Wild, Yongmann M Chung
The upper airways play a significant role in the tracheal flow dynamics. Despite many previous studies, however, the effect of upper airways on the ventilation distribution in distal airways has remained a challenge. The aim of this study is to experimentally and computationally investigate the dynamic behaviour in the intra-tracheal flow induced by the upper respiratory tract and to assess its influence on the subsequent tributaries. Patient-specific images from two different modalities (MRI of the upper airways and CT of the lower airways) were segmented and combined...
June 1, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29855163/numerical-analysis-of-electromagnetic-interactions-by-a-cell-during-the-mitosis-phases
#16
Fabio Mangini, Marco Muzi, Fabrizio Frezza
In this work, a numerical study of the interaction of an electromagnetic field with a biological cell in the different phases of mitosis is presented. In particular, the validity of the single-shell model during mitosis from a geometrical viewpoint has been considered. We consider the Jurkat cell for our analysis and model the content of the cell, composed by the nucleus and different organelles immersed in cytoplasm and delimited by the cell membrane, as a single material with appropriate electromagnetic properties derived by making use of effective medium approximation methods, i...
May 31, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29804323/effect-of-human-head-morphological-variability-on-the-mechanical-response-of-blast-overpressure-loading
#17
Kirubel Teferra, X Gary Tan, Athanasios Iliopoulos, John Michopoulos, Siddiq Qidwai
A methodology is introduced to investigate the effect of intersubject head morphological variability on the mechanical response of the brain when subjected to blast overpressure loading. Nonrigid image registration techniques are leveraged to warp a manually segmented template model to an arbitrary number of subjects following a procedure to coarsely segment the subjects in batch. Finite element meshes are autogenerated, and blast analysis is conducted. The template model is initially constructed to enable the full automated implementation and application of the proposed methodology...
May 27, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29799665/predicted-airway-obstruction-distribution-based-on-dynamical-lung-ventilation-data-a-coupled-modeling-machine-learning-methodology
#18
N Pozin, S Montesantos, I Katz, M Pichelin, I Vignon-Clementel, C Grandmont
In asthma and chronic obstructive pulmonary disease, some airways of the tracheobronchial tree can be constricted, from moderate narrowing up to closure. Those pathological patterns of obstructions affect the lung ventilation distribution. While some imaging techniques enable visualization and quantification of constrictions in proximal generations, no noninvasive technique exists to provide the airway morphology and obstruction distribution in distal areas. In this work, we propose a method that exploits lung ventilation measures to access positions of airway obstructions (restrictions and closures) in the tree...
May 25, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29799170/finite-element-analysis-of-the-influence-of-three-joint-spinal-complex-on-the-change-of-the-intervertebral-disc-bulge-and-height
#19
Klaudia Szkoda-Poliszuk, Małgorzata Żak, Celina Pezowicz
This study evaluated the changes of height and bulging occurring in individual layers of the annulus fibrosus of the intervertebral disc for 3 load scenarios (axial compression, flexion, and extension). The numerical model of a single motion segment of the thoracic spine was analysed for 2 different configurations, ie, for the model of a physiological segment and a segment with the posterior column removed. In the physiological segment, all annulus fibrosus layers decrease in height regardless of the applied load, bulging outside the intervertebral disc...
May 25, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29790664/the-dynamics-of-a-healthy-and-infected-red-blood-cell-in-flow-through-constricted-channels-a-dpd-simulation
#20
Sazid Zamal Hoque, D Vijay Anand, B S V Patnaik
Understanding the dynamics of red blood cell (RBC) motion under in silico conditions is central to the development of cost-effective diagnostic tools. Specifically, unraveling the relationship between the rheological properties and the nature of shape change in the RBC (healthy or infected) can be extremely useful. In case of malarial infection, RBC progressively loses its deformability and tends to occlude the microvessel. In the present study, detailed mesoscopic simulations are performed to investigate the deformation dynamics of an RBC in flow through a constricted channel...
May 23, 2018: International Journal for Numerical Methods in Biomedical Engineering
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