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International Journal for Numerical Methods in Biomedical Engineering

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https://www.readbyqxmd.com/read/28098434/method-for-the-unique-identification-of-hyperelastic-material-properties-using-full-field-measures-application-to-the-passive-myocardium-material-response
#1
Luigi E Perotti, Aditya V Ponnaluri, Shankarjee Krishnamoorthi, Daniel Balzani, Daniel B Ennis, William S Klug
Quantitative measurement of the material properties (e.g., stiffness) of biological tissues is poised to become a powerful diagnostic tool. There are currently several methods in the literature to estimating material stiffness and we extend this work by formulating a framework that leads to uniquely identified material properties. We design an approach to work with full field displacement data - i.e., we assume the displacement field due to the applied forces is known both on the boundaries and also within the interior of the body of interest - and seek stiffness parameters that lead to balanced internal and external forces in a model...
January 18, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28058781/multi-photon-microscope-measurement-based-biphasic-multi-scale-analyses-of-knee-joint-articular-cartilage-and-chondrocyte-by-using-visco-anisotropic-hyperelastic-finite-element-method-and-smoothed-particle-hydrodynamics-method
#2
Eiji Nakamachi, Tomohiro Noma, Kaito Nakahara, Yoshihiro Tomita, Yusuke Morita
The articular cartilage of a knee joint has a variety of functions including dispersing stress and absorbing shock in the tissue, and lubricating the surface region of cartilage. The metabolic activity of chondrocytes under the cyclic mechanical stimulations regenerates the morphology and function of tissues. Hence, the stress evaluation of the chondrocyte is vital subject to assess the regeneration cycle in the normal walking condition, and predict the injury occurrence in the accidents. Further, the threshold determination of stress for the chondrocytes activation is valuable for development of regenerative bio-reactor of articular cartilage...
January 5, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28052555/computational-modeling-of-tracheal-angioedema-due-to-swelling-of-the-submucous-tissue-layer
#3
Kun Gou, Thomas J Pence
Angioedema is a tissue swelling pathology due to rapid change in soft tissue fluid content. Its occurrence in the trachea is predominantly localized to the soft mucous tissue that forms the innermost tracheal layer. The biomechanical consequences, such as airway constriction, are dependent upon the ensuing mechanical interactions between all of the various tissues that comprise the tracheal tube. We model the stress interactions by treating the trachea organ as a three-tissue system consisting of swellable mucous in conjunction with nonswelling cartilage and nonswelling trachealis musculature...
January 4, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28039961/high-resolution-data-assimilation-of-cardiac-mechanics-applied-to-a-dyssynchronous-ventricle
#4
Gabriel Balaban, Henrik Finsberg, Hans Henrik Odland, Marie Rognes, Stian Ross, Joakim Sundnes, Samuel Wall
Computational models of cardiac mechanics, personalized to a patient, offer access to mechanical information above and beyond direct medical imaging. Additionally, such models can be used to optimize and plan therapies in-silico, thereby reducing risks and improving patient outcome. Model personalization has traditionally been achieved by data assimilation, which is the tuning or optimization of model parameters to match patient observations. Current data assimilation procedures for cardiac mechanics are limited in their ability to efficiently handle high dimensional parameters...
December 31, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28024117/quantitative-validation-of-anti-ptbp1-antibody-for-diagnostic-neuropathology-use-image-analysis-approach
#5
Evgin Goceri, Behiye Goksel, James B Elder, Vinay K Puduvalli, Jose J Otero, Metin N Gurcan
Traditional diagnostic neuropathology relies on subjective interpretation of visual data obtained from a brightfield microscopy. This approach causes high variability, unsatisfactory reproducibility and inability for multiplexing even among experts. These problems may affect patient outcomes and confound clinical decision-making. Also, standard histological processing of pathological specimens leads to auto-fluorescence and other artifacts, a reason why fluorescent microscopy is not routinely implemented in diagnostic pathology...
December 26, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27943622/uncertainty-quantification-of-inflow-boundary-condition-and-proximal-arterial-stiffness-coupled-effect-on-pulse-wave-propagation-in-a-vascular-network
#6
Antoine Brault, Laurent Dumas, Didier Lucor
This work aims at quantifying the effect of inherent uncertainties from cardiac output on the sensitivity of a human compliant arterial network response based on stochastic simulations of a reduced-order pulse wave propagation model. A simple pulsatile output form is utilized to reproduce the most relevant cardiac features with a minimum number of parameters associated with left ventricle dynamics. Another source of significant uncertainty is the spatial heterogeneity of the aortic compliance which plays a key role in the propagation and damping of pulse waves generated at each cardiac cycle...
December 10, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27935265/modelling-mitral-valvular-dynamics-current-trend-and-future-directions
#7
Hao Gao, Nan Qi, Liuyang Feng, Xingshuang Ma, Mark Danton, Colin Berry, Xiaoyu Luo
Dysfunction of mitral valve causes morbidity and premature mortality and remains a leading medical problem worldwide. Computational modelling aims to understand the biomechanics of human mitral valve and could lead to the development of new treatment, prevention and diagnosis of mitral valve diseases. Compared with the aortic valve, the mitral valve has been much less studied owing to its highly complex structure and strong interaction with the blood flow and the ventricles. However, the interest in mitral valve modelling is growing, and the sophistication level is increasing with the advanced development of computational technology and imaging tools...
December 9, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27921393/the-role-of-the-microvascular-network-structure-on-diffusion-and-consumption-of-anti-cancer-drugs
#8
P Mascheroni, R Penta
We investigate the impact of microvascular geometry on the transport of drugs in solid tumors, focusing on the diffusion and consumption phenomena. We embrace recent advances in the asymptotic homogenization literature starting from a double Darcy, double advection-diffusion-reaction system of partial differential equations that is obtained exploiting the sharp length separation between the intercapillary distance and the average tumor size. The geometric information on the microvascular network is encoded into effective hydraulic conductivities and diffusivities, which are numerically computed by solving periodic cell problems on appropriate microscale representative cells...
December 6, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27885825/multiphase-fluid-solid-coupled-analysis-of-shock-bubble-stone-interaction-in-shockwave-lithotripsy
#9
K G Wang
A novel multiphase fluid-solid coupled computational framework is applied to investigate the interaction of a kidney stone immersed in liquid with a lithotripsy shock wave (LSW) and a gas bubble near the stone. The main objective is to elucidate the effects of a bubble in the shock path to the elastic and fracture behaviors of the stone. The computational framework couples a finite volume two-phase computational fluid dynamics (CFD) solver with a finite element (FE) computational solid dynamics (CSD) solver...
November 24, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27885813/a-novel-modelling-approach-to-energy-transport-in-a-respiratory-system
#10
Perumal Nithiarasu, Igor Sazonov
In this paper, energy transport in a respiratory tract is modelled using the finite element method for the first time. The upper and lower respiratory tracts are approximated as a one-dimensional domain with varying cross sectional and surface areas and the radial heat conduction in the tissue is approximated using the one dimensional cylindrical coordinate system. The governing equations are solved using one-dimensional linear finite elements with convective and evaporative boundary conditions on the wall...
November 24, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27883273/a-velocity-tracking-approach-for-the-data-assimilation-problem-in-blood-flow-simulations
#11
J Tiago, T Guerra, A Sequeira
Several advances have been made in Data Assimilation techniques applied to blood flow modeling. Typically, idealized boundary conditions, only verified in straight parts of the vessel, are assumed. We present a general approach, based on a Dirichlet boundary control problem, that may potentially be used in different parts of the arterial system. The relevance of this method appears when computational reconstructions of the 3D domains, prone to be considered sufficiently extended, are either not possible, or desirable, due to computational costs...
November 24, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27863152/direct-numerical-simulation-of-transitional-hydrodynamics-of-the-cerebrospinal-fluid-in-chiari-i-malformation-the-role-of-cranio-vertebral-junction
#12
Kartik Jain, Geir Ringstad, Per-Kristian Eide, Kent-André Mardal
Obstruction to the cerebrospinal fluid (CSF) outflow caused by the herniation of cerebellar tonsils as a result of Chiari malformation type I leads to altered CSF hydrodynamics. This contribution explores the minutest characteristics of the CSF hydrodynamics in cervical subarachnoid spaces (SAS) of a healthy subject and two Chiari patients by performing highly resolved direct numerical simulation. The Lattice Boltzmann method is used for the simulations due to its scalability on modern supercomputers that allow us to simulate up to  ∼ 10(9) cells while resolving the Kolmogorov microscales...
November 10, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27863131/conditions-of-microvessel-occlusion-for-blood-coagulation-in-flow
#13
A Bouchnita, T Galochkina, P Kurbatova, P Nony, V Volpert
Vessel occlusion is a perturbation of blood flow inside a blood vessel because of the fibrin clot formation. As a result, blood circulation in the vessel can be slowed down or even stopped. This can provoke the risk of cardiovascular events. In order to explore this phenomenon, we used a previously developed mathematical model of blood clotting to describe the concentrations of blood factors with a reaction-diffusion system of equations. The Navier-Stokes equations were used to model blood flow and we treated the clot as a porous medium...
November 10, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27863119/adaptive-unified-continuum-fem-modeling-of-a-3d-fsi-benchmark-problem
#14
Johan Jansson, Niyazi Cem Degirmenci, Johan Hoffman
In this paper we address a 3D fluid-structure interaction (FSI) benchmark problem that represents important characteristics of biomedical modeling. We present a goal-oriented adaptive finite element methodology for incompressible FSI based on a streamline-diffusion type stabilization of the balance equations for mass and momentum for the entire continuum in the domain, which is implemented in the Unicorn/FEniCS software framework. A phase marker function and its corresponding transport equation is introduced to select the constitutive law, where the mesh tracks the discontinous fluid-structure interface...
November 10, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27863120/numerical-simulation-of-volume-controlled-mechanical-ventilated-respiratory-system-with-2-different-lungs
#15
Yan Shi, Bolun Zhang, Maolin Cai, Xiaohua Douglas Zhang
Mechanical ventilation is a key therapy for patients who cannot breathe adequately by themselves, and dynamics of mechanical ventilation system is of great significance for life support of patients. Recently, models of mechanical ventilated respiratory system with 1 lung are used to simulate the respiratory system of patients. However, humans have 2 lungs. When the respiratory characteristics of 2 lungs are different, a single-lung model cannot reflect real respiratory system. In this paper, to illustrate dynamic characteristics of mechanical ventilated respiratory system with 2 different lungs, we propose a mathematical model of mechanical ventilated respiratory system with 2 different lungs and conduct experiments to verify the model...
November 9, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28029755/a-novel-approach-to-the-quantification-of-aortic-root-in-vivo-structural-mechanics
#16
E Votta, M Presicce, A Della Corte, S Dellegrottaglie, C Bancone, F Sturla, A Redaelli
Understanding aortic root in vivo biomechanics can help in elucidating key mechanisms involved in aortic root pathologies and in the outcome of their surgical treatment. Numerical models can provide useful quantitative information. For this to be reliable, detailed aortic root anatomy should be captured. Also, since the aortic root is never unloaded throughout the cardiac cycle, the modeled geometry should be consistent with the in vivo loads acting on it. Achieving such consistency is still a challenge, which was tackled only by few numerical studies...
November 7, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27813346/validation-of-a-non-conforming-monolithic-fluid-structure-interaction-method-using-phase-contrast-mri
#17
A Hessenthaler, O Röhrle, D A Nordsletten
This paper details the validation of a non-conforming arbitrary Lagrangian-Eulerian fluid-structure interaction (FSI) technique using a recently developed experimental 3D FSI benchmark problem. Numerical experiments for steady and transient test cases of the benchmark were conducted employing an inf-sup stable and a general Galerkin scheme. The performance of both schemes is assessed. Spatial refinement with three mesh refinement levels and fluid domain truncation with two fluid domain lengths are studied as well as employing a sequence of increasing time step sizes for steady-state cases...
November 4, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27813272/experiment-for-validation-of-fluid-structure-interaction-models-and-algorithms
#18
A Hessenthaler, N R Gaddum, O Holub, R Sinkus, O Röhrle, D A Nordsletten
In this paper a fluid-structure interaction (FSI) experiment is presented. The aim of this experiment is to provide a challenging yet easy-to-setup FSI test case that addresses the need for rigorous testing of FSI algorithms and modeling frameworks. Steady-state and periodic steady-state test cases with constant and periodic inflow were established. Focus of the experiment is on biomedical engineering applications with flow being in the laminar regime with Reynolds numbers 1283 and 651. Flow and solid domains were defined using CAD tools...
November 4, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27860424/aerosol-transport-throughout-inspiration-and-expiration-in-the-pulmonary-airways
#19
Jessica M Oakes, Shawn C Shadden, Céline Grandmont, Irene E Vignon-Clementel
Little is known about transport throughout the respiration cycle in the conducting airways. It is challenging to appropriately describe the time-dependent number of particles entering back into the model during exhalation. Modeling the entire lung is not feasible; therefore multi-domain methods must be employed. Here, we present a new framework that is designed to simulate particles throughout the respiration cycle, incorporating realistic airway geometry and respiration. This framework is applied for a healthy rat lung exposed to  ∼ 1μm diameter particles to facilitate parameterization and validation...
November 2, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27796075/an-atlas-and-data-driven-approach-to-initializing-reaction-diffusion-systems-in-computer-cardiac-electrophysiology
#20
Corné Hoogendoorn, Rafael Sebastian, José Félix Rodriguez, Karim Lekadir, Alejandro F Frangi
The cardiac electrophysiology (EP) problem is governed by a nonlinear anisotropic reaction-diffusion system with a very rapidly varying reaction term associated with the transmembrane cell current. The nonlinearity associated with the cell models requires a stabilization process before any simulation is carried out. More importantly, when used in a three-dimensional (3D) anatomy, it is not sufficient to perform this stabilization on the basis of isolated cells only, since the coupling of the different cells through the tissue greatly modulates the dynamics of the system...
October 30, 2016: International Journal for Numerical Methods in Biomedical Engineering
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