journal
MENU ▼
Read by QxMD icon Read
search

Science China. Life Sciences

journal
https://www.readbyqxmd.com/read/28434132/water-regulation-a-sword-of-damocles-for-migratory-waterbirds-in-china
#1
Yifei Jia, Guangchun Lei, Xiubo Yu
No abstract text is available yet for this article.
April 20, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28424968/visualization-of-reticulophagy-in-living-cells-using-an-endoplasmic-reticulum-targeted-p62-mutant
#2
Liang Wang, Lei Liu, Lingsong Qin, Qingming Luo, Zhihong Zhang
Reticulophagy is a type of selective autophagy in which protein aggregate-containing and/or damaged endoplasmic reticulum (ER) fragments are engulfed for lysosomal degradation, which is important for ER homeostasis. Several chemical drugs and mutant proteins that promote protein aggregate formation within the ER lumen can efficiently induce reticulophagy in mammalian cells. However, the exact mechanism and cellular localization of reticulophagy remain unclear. In this report, we took advantage of the self-oligomerization property of p62/SQSTM1, an adaptor for selective autophagy, and developed a novel reticulophagy system based on an ER-targeted p62 mutant to investigate the process of reticulophagy in living cells...
April 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28405795/erratum-to-acidic-domains-differentially-read-histone-h3-lysine-4-methylation-status-and-are-widely-present-in-chromatin-associated-proteins
#3
Meng Wu, Wei Wei, Jiwei Chen, Rong Cong, Tieliu Shi, Jiwen Li, Jiemin Wong, James X Du
No abstract text is available yet for this article.
April 12, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28378154/plant-derived-phosphocholine-facilitates-cellular-uptake-of-anti-pulmonary-fibrotic-hjt-srna-m7
#4
Jianchao Du, Zhu Liang, Jiantao Xu, Yan Zhao, Xiaoyun Li, Yanli Zhang, Dandan Zhao, Ruxuan Chen, Yang Liu, Trupti Joshi, Jiahui Chang, Zhiqing Wang, Yanxu Zhang, Jindong Zhu, Qiang Liu, Dong Xu, Chengyu Jiang
Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian (HJT, Rhodiola crenulata can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying (PGY, Taraxacum mongolicum), Chuan Xin Lian (CXL, Andrographis paniculata), and Jin Yin Hua (JYH, lonicera japonica or Honeysuckle)...
March 31, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28353190/the-day-after-the-7th-day-of-the-creation-breakthrough-of-human-embryo-in-vitro-culture
#5
Hui Gao, Wei Li
No abstract text is available yet for this article.
March 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28349305/profile-of-yi-han-chen
#6
(no author information available yet)
No abstract text is available yet for this article.
March 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28349304/rapid-generation-of-genetic-diversity-by-multiplex-crispr-cas9-genome-editing-in-rice
#7
Lan Shen, Yufeng Hua, Yaping Fu, Jian Li, Qing Liu, Xiaozhen Jiao, Gaowei Xin, Junjie Wang, Xingchun Wang, Changjie Yan, Kejian Wang
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated endonuclease 9 (CRISPR/Cas9) system has emerged as a promising technology for specific genome editing in many species. Here we constructed one vector targeting eight agronomic genes in rice using the CRISPR/Cas9 multiplex genome editing system. By subsequent genetic transformation and DNA sequencing, we found that the eight target genes have high mutation efficiencies in the T0 generation. Both heterozygous and homozygous mutations of all editing genes were obtained in T0 plants...
March 24, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28349303/mechanistic-and-therapeutic-perspectives-for-cardiac-arrhythmias-beyond-ion-channels
#8
REVIEW
Yufei Wu, Jun Li, Liang Xu, Li Lin, Yi-Han Chen
Cardiac arrhythmias are among the most common causes of death in the world. Foundational studies established the critical role of ion channel disorders in arrhythmias, yet defects in ion channels themselves, such as mutations, may not account for all arrhythmias. Despite the progress made in recent decades, the antiarrhythmic drugs currently available have limited effectiveness, and the majority of these drugs can have proarrhythmic effects. This review describes novel knowledge on cellular mechanisms that cause cardiac arrhythmias, focuses on the dysfunction of subcellular organelles and intracellular logistics, and discusses potential strategies and challenges for developing novel, safe and effective treatments for arrhythmias...
March 24, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28321657/novel-hemostatic-agents-based-on-gelatin-microbial-transglutaminase-mix
#9
Fang Lv, Xiaonan Cong, Wenshu Tang, Yiming Han, Yu Tang, Yongrui Liu, Liqiang Su, Mingyao Liu, Mingfei Jin, Zhengfang Yi
Hemostasis is a major challenge in surgical procedures and traumas. Conventional hemostatic methods have limited efficacy and may cause additional tissue damage. In this study, we designed a novel hemostatic agent based on the in situ gel formation of gelatin cross-linked by a novel microbial transglutaminase (mTGase), in which the amino acid sequences differed from commercial mTGases. The new hemostatic agent showed the same biochemical crosslinking chemistry as the final stages of the blood coagulation cascade while using gelatin as a "structural" protein (rather than fibrin) and a calcium-independent mTGase as the crosslinking catalyst (rather than factor XIIIa)...
March 17, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28303459/crispr-cas9-mediated-base-editing-system-efficiently-generates-gain-of-function-mutations-in-arabidopsis
#10
LETTER
Yiyu Chen, Zhiping Wang, Hanwen Ni, Yong Xu, Qijun Chen, Linjian Jiang
No abstract text is available yet for this article.
March 16, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28299578/future-science-prize-goes-to-non-invasive-prenatal-testing
#11
Kang Li, Yaou Duan, Magdalene Yin Lin Ting, Zhiying Ou, Li Liu, Kang Zhang, Xin Fu
No abstract text is available yet for this article.
March 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28299577/a-novel-strategy-to-generate-virus-vaccines-with-expanded-genetic-codes
#12
Deyin Guo
No abstract text is available yet for this article.
March 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28299576/a-natural-communication-system-on-genome-evolution
#13
Qi Wu, Yadi Wang, Yun Ding, Shuai Ma, Zongmin Wu, Fuwen Wei
No abstract text is available yet for this article.
March 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28299575/phylogenetic-constrains-on-mycorrhizal-specificity-in-eight-dendrobium-orchidaceae-species
#14
Xiaoke Xing, Xueting Ma, Jinxin Men, Yanhong Chen, Shunxing Guo
Plant phylogeny constrains orchid mycorrhizal (OrM) fungal community composition in some orchids. Here, we investigated the structures of the OrM fungal communities of eight Dendrobium species in one niche to determine whether similarities in the OrM fungal communities correlated with the phylogeny of the host plants and whether the Dendrobium-OrM fungal interactions are phylogenetically conserved. A phylogeny based on DNA data was constructed for the eight coexisting Dendrobium species, and the OrM fungal communities were characterized by their roots...
March 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28293812/the-substitution-v379i-in-pa-protein-attenuates-the-pathogenicity-of-influenza-a-h1n1-pdm09-viruses-in-mice
#15
LETTER
Yongkun Chen, Wenfei Zhu, Tian Bai, Xiaohui Zou, Siyu Zhang, Yan Sun, Xiyan Li, Xingyu Xiang, Qinglong Zhao, Chaoyang Huang, Tao Chen, Dayan Wang, Yuelong Shu
No abstract text is available yet for this article.
March 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28260228/a-crispr-cas9-toolkit-for-efficient-targeted-base-editing-to-induce-genetic-variations-in-rice
#16
LETTER
Bin Ren, Fang Yan, Yongjie Kuang, Na Li, Dawei Zhang, Honghui Lin, Huanbin Zhou
No abstract text is available yet for this article.
March 3, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28251462/genetic-technologies-for-extremely-thermophilic-microorganisms-of-sulfolobus-the-only-genetically-tractable-genus-of-crenarchaea
#17
REVIEW
Nan Peng, Wenyuan Han, Yingjun Li, Yunxiang Liang, Qunxin She
Archaea represents the third domain of life, with the information-processing machineries more closely resembling those of eukaryotes than the machineries of the bacterial counterparts but sharing metabolic pathways with organisms of Bacteria, the sister prokaryotic phylum. Archaeal organisms also possess unique features as revealed by genomics and genome comparisons and by biochemical characterization of prominent enzymes. Nevertheless, diverse genetic tools are required for in vivo experiments to verify these interesting discoveries...
February 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28251461/the-genome-wide-molecular-regulation-of-mouse-gastrulation-embryo
#18
REVIEW
Guangdun Peng, Naihe Jing
The diverse morphologies among vertebrate species stems from the evolution of a basic body plan that is constituted by a spatially organized ensemble of tissue lineage progenitors. At gastrulation, this body plan is established through a coordinated morphogenetic process and the delineation of tissue lineages that are driven by the activity of the genome. To explore the molecular mechanisms, in a comprehensive context, it is imperative to glean an understanding of the region- and population-specific genetic activity underpinning this fundamental developmental process...
February 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28251460/characterization-of-a-disease-susceptibility-locus-for-exploring-an-efficient-way-to-improve-rice-resistance-against-bacterial-blight
#19
Qi Cheng, Weihua Mao, Wenya Xie, Qinsong Liu, Jianbo Cao, Meng Yuan, Qinglu Zhang, Xianghua Li, Shiping Wang
Bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is the most harmful bacterial disease of rice worldwide. Previously, we characterized major disease resistance (MR) gene xa25, which confers race-specific resistance to Xoo strain PXO339. The xa25 is a recessive allele of the SWEET13 locus, but SWEET13's interaction with PXO339 and how efficiently using this locus for rice breeding still need to be defined. Here we show that the SWEET13 allele from rice Zhenshan 97 is a susceptibility gene to PXO339...
February 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28251459/lycorine-inhibits-breast-cancer-growth-and-metastasis-via-inducing-apoptosis-and-blocking-src-fak-involved-pathway
#20
Xuexiang Ying, Anling Huang, Yajing Xing, Liping Lan, Zhengfang Yi, Pingqing He
Breast cancer is the most commonly diagnosed cancer type worldwide among women and more than 90% of patients die from tumor metastasis. Lycorine, a natural alkaloid, has been widely reported possessing potential efficacy against cancer proliferation and metastasis. In our study, the anti-tumor potency on breast cancer was evaluated in vitro and in vivo for the first time. Our results indicated that lycorine inhibited breast cancer cells growth, migration and invasion as well as induced their apoptosis. In in vivo study, lycorine not only suppressed breast tumor growth in xenograft models and inhibited breast tumor metastasis in MDA-MB-231 tail vein model...
February 27, 2017: Science China. Life Sciences
journal
journal
42980
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"