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Science China. Life Sciences

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https://www.readbyqxmd.com/read/28194553/acidic-domains-differentially-read-histone-h3-lysine-4-methylation-status-and-are-widely-present-in-chromatin-associated-proteins
#1
Meng Wu, Wei Wei, Jiwei Chen, Rong Cong, Tieliu Shi, Jiwen Li, Jiemin Wong, James X Du
Histone methylation is believed to provide binding sites for specific reader proteins, which translate histone code into biological function. Here we show that a family of acidic domain-containing proteins including nucleophosmin (NPM1), pp32, SET/TAF1β, nucleolin (NCL) and upstream binding factor (UBF) are novel H3K4me2-binding proteins. These proteins exhibit a unique pattern of interaction with methylated H3K4, as their binding is stimulated by H3K4me2 and inhibited by H3K4me1 and H3K4me3. These proteins contain one or more acidic domains consisting mainly of aspartic and/or glutamic residues that are necessary for preferential binding of H3K4me2...
February 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28194552/a-novel-synthetic-small-molecule-yf-452-inhibits-tumor-growth-through-antiangiogenesis-by-suppressing-vegf-receptor-2-signaling
#2
Yongrui Liu, Yuan He, Feifei Yang, Xiaonan Cong, Jinhua Wang, Shihong Peng, Dan Gao, Weifang Wang, Liping Lan, Xuexiang Ying, Mingyao Liu, Yihua Chen, Zhengfang Yi
Tumor angiogenesis is characterized by abnormal vessel morphology, endowing tumor with highly hypoxia and unresponsive toward treatment. To date, mounting angiogenic factors have been discovered as therapeutic targets in antiangiogenic drug development. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors exerts potent antiangiogenic activity in tumor therapy. Therefore, it may provide a valid strategy for cancer treatment through targeting the tumor angiogenesis via VEGFR2 pathway...
February 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28120269/presenilin-2-deficiency-facilitates-a%C3%AE-induced-neuroinflammation-and-injury-by-upregulating-p2x7-expression
#3
Juliang Qin, Xiaoyu Zhang, Ziqiang Wang, Jinju Li, Zhen Zhang, Liangcai Gao, Hua Ren, Min Qian, Bing Du
Accumulating evidence suggests that β-amyloid (Aβ)-induced neuroinflammation plays a prominent and early role in Alzheimer's disease (AD). In this study, we demonstrated that Presenilin 2 (PS2) deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 expression both in vitro and in vivo. PS2 knockout mice demonstrated increased cognitive impairments and cerebral injury. PS2 deficiency increased the expression of P2X7 both in neurons and microglial cells. Furthermore, extracellular ATP also increased in both Aβ-treated and untreated PS2 knockout microglial cells...
January 23, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28120268/long-non-coding-rnas-play-an-important-role-in-regulating-photoperiod-and-temperature-sensitive-male-sterility-in-rice
#4
Jingxin Guo, Yao-Guang Liu
No abstract text is available yet for this article.
January 23, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28120267/competition-between-toxic-and-nontoxic-microcystis-cyanophyceae-under-different-light-and-temperature-conditions
#5
LETTER
Yinxia Li, Yiwen Wu, Bibo Liu, Dunhai Li
No abstract text is available yet for this article.
January 22, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28120266/identification-of-twist-interacting-genes-in-prostate-cancer
#6
Peng Lyu, Shu-Dong Zhang, Hiu-Fung Yuen, Cian M McCrudden, Qing Wen, Kwok-Wah Chan, Hang Fai Kwok
Prostate cancer is one of the most common cancers in men worldwide, and the number of diagnosed patients has dramatically increased in recent years. Currently, the clinical parameters used to diagnose prostate cancer, such as Gleason score, pathological tumor staging, and prostate-specific antigen (PSA) expression level, are considered insufficient to inform recommendation to guide clinical practice. Thus, identification of a novel biomarker is necessary. TWIST is one of the well-studied targets and is correlated with cancer invasion and metastasis in several human cancers...
January 22, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28120265/china-is-initiating-the-aquatic-10-100-1-000-genomics-program
#7
Yingjie Liu, Pao Xu, Junmin Xu, Yu Huang, Yongxin Liu, Hui Fang, Yinchang Hu, Xinxin You, Chao Bian, Min Sun, Ruobo Gu, Lifeng Cui, Xianliang Zhang, Peng Xu, Qiong Shi
No abstract text is available yet for this article.
January 21, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28108947/zika-virus-infection-do-they-also-endanger-male-fertility
#8
Nafis A Rahman, Ilpo Huhtaniemi
No abstract text is available yet for this article.
January 17, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28074383/poisoning-the-pika-must-protection-of-grasslands-be-at-the-expense-of-biodiversity
#9
Lan Wu, Hao Wang
No abstract text is available yet for this article.
January 10, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28063009/dna-methylation-signatures-in-circulating-cell-free-dna-as-biomarkers-for-the-early-detection-of-cancer
#10
REVIEW
Junyun Wang, Xiao Han, Yingli Sun
Detecting cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) in plasma or serum could serve as a "liquid biopsy", which would be useful for numerous diagnostic applications. cfDNA methylation detection is one of the most promising approaches for cancer risk assessment. Here, we reviewed the literature related to the use of serum or plasma circulating cell-free DNA for cancer diagnosis in the early stage and their power as future biomarkers.
January 5, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28083722/will-cancer-cells-be-defeated-by-sodium-bicarbonate
#11
Hongtao Zhang
No abstract text is available yet for this article.
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078509/psg9-promotes-angiogenesis-by-stimulating-vegfa-production-and-is-associated-with-poor-prognosis-in-hepatocellular-carcinoma
#12
Weiqi Rong, Lei Yang, Liyuan Yin, Yanning Gao, Ting Xiao, Shujun Cheng
Hepatocellular carcinoma (HCC) is a common malignant solid tumor characterized by rich vascularization. Pregnancy-specific glycoprotein 9 (PSG9) is a member of the carcinoembryonic antigen (CEA)/PSG family and is produced at high levels during pregnancy. We previously identified PSG9 as an HCC-related protein. However, the expression of PSG9 and its regulation during HCC carcinogenesis remain poorly explored. In the present study, we first found that the levels of PSG9 protein were significantly increased in the plasma of HCC patients...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078506/regulation-of-p53-acetylation
#13
Wei-Guo Zhu
No abstract text is available yet for this article.
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28025761/npr1-dependent-salicylic-acid-signaling-inhibits-agrobacterium-mediated-transient-expression-in-arabidopsis
#14
LETTER
Wenliu Zhu, Xiaotong Hu, Chongyang Wang, Shunping Yan
No abstract text is available yet for this article.
December 20, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/28000017/high-throughput-development-of-genome-wide-locus-specific-informative-ssr-markers-in-wheat
#15
LETTER
Lei Li, Fayu Sun, Di Wu, Fei Zhen, Guihua Bai, Derong Gao, Tao Li
No abstract text is available yet for this article.
December 16, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27921234/simultaneous-virus-identification-and-characterization-of-severe-unexplained-pneumonia-cases-using-a-metagenomics-sequencing-technique
#16
Xiaohui Zou, Guangpeng Tang, Xiang Zhao, Yan Huang, Tao Chen, Mingyu Lei, Wenbing Chen, Lei Yang, Wenfei Zhu, Li Zhuang, Jing Yang, Zhaomin Feng, Dayan Wang, Dingming Wang, Yuelong Shu
Many viruses can cause respiratory diseases in humans. Although great advances have been achieved in methods of diagnosis, it remains challenging to identify pathogens in unexplained pneumonia (UP) cases. In this study, we applied next-generation sequencing (NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province, China. A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS. An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples...
December 2, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27921236/root-morphology-in-response-to-nitrogen-supply-in-mid-season-indica-rice-cultivars-released-in-different-decades
#17
LETTER
Yikai Zhang, Huizhe Chen, Yuping Zhang, Jing Xiang, Guangmei Ji, Defeng Zhu
No abstract text is available yet for this article.
December 1, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27921235/transplantation-of-collagen-scaffold-with-autologous-bone-marrow-mononuclear-cells-promotes-functional-endometrium-reconstruction-via-downregulating-%C3%AE-np63-expression-in-asherman-s-syndrome
#18
Guangfeng Zhao, Yun Cao, Xianghong Zhu, Xiaoqiu Tang, Lijun Ding, Haixiang Sun, Juan Li, Xinan Li, Chenyan Dai, Tong Ru, Hui Zhu, Jingjie Lu, Caimei Lin, Jingmei Wang, Guijun Yan, Huiyan Wang, Lei Wang, Yimin Dai, Bin Wang, Ruotian Li, Jianwu Dai, Yan Zhou, Yali Hu
Asherman's syndrome (AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells (BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration...
December 1, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27888388/cardiac-bin1-cbin1-is-a-regulator-of-cardiac-contractile-function-and-an-emerging-biomarker-of-heart-muscle-health
#19
REVIEW
Kang Zhou, Tingting Hong
In recent decades, a cardiomyocyte membrane scaffolding protein bridging integrator 1 (BIN1) has emerged as a critical multifunctional regulator of transverse-tubule (t-tubule) function and calcium signaling in cardiomyocytes. Encoded by a single gene with 20 exons that are alternatively spliced, more than ten BIN1 protein isoforms are expressed with tissue and disease specificity. The recently discovered cardiac alternatively spliced isoform BIN1 (cBIN1 or BIN1+13+17) plays a crucial role in organizing membrane microfolds within cardiac t-tubules...
November 23, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27888387/incubation-experiment-demonstrates-effects-of-carbon-and-nitrogen-on-microbial-phosphate-solubilizing-function
#20
LETTER
Hongyang Sun, Yanhong Wu, Jun Zhou, Haijian Bing
No abstract text is available yet for this article.
November 23, 2016: Science China. Life Sciences
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