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Science China. Life Sciences

Chuansong Quan, Ting Huang, Xiuwei Chen, Jie Zhang, Qianli Wang, Cheng Zhang, Tiyan Zhang, Lijun Zhou, Liumei Shu, Chunrong Long, Lei Yang, Xunbo Du, Yingze Zhao, Peipei Liu, Hao Song, Weifeng Shi, Yuhai Bi, Qiang Lv, William J Liu, George F Gao
No abstract text is available yet for this article.
July 9, 2018: Science China. Life Sciences
Shiyun Wang, Rong Zhang, Xuhong Hou, Fusong Jiang, Jie Wang, Zhen He, Feng Jiang, Cheng Hu, Weiping Jia
We aim to investigate the relationship between serum somatostatin (SST) levels and glucose-lipid metabolism at various stages of glucose tolerance in the Jino ethnic minority (n=111) and Han population (n=113) of Yunnan Province, southwest China. Anthropometric parameters and biochemical traits were measured. Serum SST and plasma glucagon levels were tested. Participants were divided into three subgroups: isolated fasting hyperglycemia (IFH), isolated post challenge hyperglycemia (IPH) and normal glucose tolerance (NGT)...
July 9, 2018: Science China. Life Sciences
Jie Li, Daoqian Yu, Ghulam Qanmber, Lili Lu, Lingling Wang, Lei Zheng, Zhao Liu, Huanhuan Wu, Xiaodong Liu, Quanjia Chen, Fuguang Li, Zuoren Yang
Drought stress results in significant losses in agricultural production, and especially that of cotton. The molecular mechanisms that coordinate drought tolerance remain elusive in cotton. Here, we isolated a drought-response gene GhKLCR1, which is a close homolog of AtKLCR1, which encodes a kinesin light chain-related protein enriched with a tetratrico peptide-repeat region. A subcellular localization assay showed that GhKLCR1 is associated with the cell membrane. A tissue-specific expression profile analysis demonstrated that GhKLCR1 is a cotton root-specific gene...
July 6, 2018: Science China. Life Sciences
Ziru Jiang, Li Jin, Weihui Shi, Ji Xi, Yulian Hu, Xinmei Liu, Jianzhong Sheng, Guolian Ding, Hefeng Huang
To investigate the effect of basal hormone levels including follicle stimulating hormone (FSH) and estradiol (E2 ) and age on the pregnancy outcomes in women undergoing in vitro fertilization and embryo transfer (IVF-ET), we designed a retrospective cohort analysis and collected information of patients undergoing IVF between January 2014 and April 2017. We found that young women had much better pregnancy outcomes than older women regardless of the hormone levels. The pregnancy outcomes declined in young women with high basal E2 , even though they had normal FSH...
July 6, 2018: Science China. Life Sciences
Lanlan Meng, Chaofeng Tu, Guangxiu Lu, Ge Lin, Yueqiu Tan
No abstract text is available yet for this article.
June 28, 2018: Science China. Life Sciences
Yan Huang, Xijin Shi, Qianying Mao, Yan Zhang, Xin Cong, Xueming Zhang, Zhejing Zhang, Liling Wu, Ruolan Xiang, Guangyan Yu
Autophagy is a catabolic process which is involved in the development of many diseases including diabetes mellitus and its complications. Hyposalivation is a common complication of diabetes mellitus, whereas its mechanism remains unclear. Here, we observed that the stimulated salivary flow rate of SMG was significantly decreased in db/db mice, a diabetic mice model. The expressions of aquaporin 5 (AQP5), a water channel protein, were decreased, whereas the mRNA level of AQP5 was increased in SMGs of both diabetic patients and mice...
June 26, 2018: Science China. Life Sciences
Qian Liu, Junwen Zhang, Hua Gao, Taoyang Yuan, Jie Kang, Lu Jin, Songbai Gui, Yazhuo Zhang
Currently, the primary therapeutic strategy for most growth hormone-producing pituitary adenomas (GHPA) is surgery. Due to the invasiveness of GHPA, high recurrence has limited the benefit of complete adenoma removal surgery. Epidermal growth factor-like domain 7 (EGFL7) is a secreted factor implicated in tumor angiogenesis, growth, invasiveness and metastasis in GHPA. Herein, we observed that the expression level of EGFL7 and p-EGFR in invasive GHPA was much higher than that of non-invasive GHPA. The overexpression of EGFL7 was positively correlated with activation of EGFR (p-EGFR)...
June 26, 2018: Science China. Life Sciences
Feng Zhang, Daniel F Voytas
No abstract text is available yet for this article.
June 26, 2018: Science China. Life Sciences
Fanshuang Zhang, Yanying Ni, Yuan Yuan, Wei Yin, Youhe Gao
Biomarker is the change associated with the disease. Blood is relatively stable because of the homeostatic mechanisms of the body. However, urine accumulates changes of the body, which makes it a better early biomarker source. Liver fibrosis is a reversible pathological condition, whereas cirrhosis, the end-stage of liver fibrosis, is irreversible. Consequently, noninvasive early biomarkers for fibrosis are desperately needed. In this study, differential urinary proteins were identified in the thioacetamide liver fibrosis rat model using tandem mass tagging and two-dimensional liquid chromatography tandem mass spectrometry...
June 25, 2018: Science China. Life Sciences
Petros Lenas, Laertis Ikonomou
No abstract text is available yet for this article.
June 25, 2018: Science China. Life Sciences
Xi-Yin Li, Jian-Fang Gui
No abstract text is available yet for this article.
June 25, 2018: Science China. Life Sciences
Nan Qin, Xiuzhu Dong, Liping Zhao
No abstract text is available yet for this article.
June 22, 2018: Science China. Life Sciences
Xiaomin Wang, Xiaojing Zhang, Lin Ma, Shengli Li
Quantification of hepatic fat and iron content is important for early detection and monitoring of nonalcoholic fatty liver disease (NAFLD) patients. This study evaluated quantification efficiency of hepatic proton density fat fraction (PDFF) by MRI using NAFLD rabbits. R2* was also measured to investigate whether it correlates with fat levels in NAFLD. NAFLD rabbit model was successfully established by high fat and cholesterol diet. Rabbits underwent MRI examination for fat and iron analyses, compared with liver histological findings...
June 20, 2018: Science China. Life Sciences
Man Kit Tse, Ting Shing Hung, Ching Man Chan, Tiffany Wong, Mike Dorothea, Catherine Leclerc, Marc Moreau, Andrew L Miller, Sarah E Webb
The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells (NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells...
June 20, 2018: Science China. Life Sciences
Xuan Ma, Xiaofeng Cao
No abstract text is available yet for this article.
June 19, 2018: Science China. Life Sciences
Suwei Gao, Feng Liu
Fetal liver (FL) is an intricate and highly vascularized hematopoietic organ, which can support the extensive expansion of hematopoietic stem cells (HSCs) without loss of stemness, as well as of the downstream lineages of HSCs. This powerful function of FL largely benefits from the niche (or microenvironment), which provides a residence for HSC expansion. Numerous studies have demonstrated that the FL niche consists of heterogeneous cell populations that associate with HSCs spatially and regulate HSCs functionally...
June 15, 2018: Science China. Life Sciences
Luyuan Jin, Mengbi Zhang, Junji Xu, Dengsheng Xia, Chunmei Zhang, Jingsong Wang, Songlin Wang
Concentration of salivary nitrate is approximately 10-fold to that of serum. Many circumstances such as acute stress could promote salivary nitrate secretion and nitrite formation. However, whether other conditions can also be used as regulators of salivary nitrate/nitrite has not yet been explored. The present study was designed to determine the influence of exposure to different music on the salivary flow rate and nitrate secretion and nitrite formation. Twenty-four undergraduate students (12 females and 12 males) were exposed to silence, rock music, classical music or white noise respectively on four consecutive mornings...
June 15, 2018: Science China. Life Sciences
Fanfan Zhu, Boren Jiang, Rongliang Ren, Lizhen Yang
No abstract text is available yet for this article.
June 15, 2018: Science China. Life Sciences
Qingfeng Liu, Yanhua Qi, Qiuli Liang, Xiujuan Xu, Fangzhou Hu, Jing Wang, Jun Xiao, Shi Wang, Wuhui Li, Min Tao, Qinbo Qin, Rurong Zhao, Zhanzhou Yao, Shaojun Liu
Hybridization can combine the genomes of different strains or species, which leads to changes of genotype and phenotype in the hybrids. In this study, we aimed to investigate the genetic variations of hybrids (WR-F1 and WR-F2 ) derived from the intraspecific hybridization of white crucian carp (Carassius auratus cuvieri, WCC, ♀) and red crucian carp (Carassius auratus red var., RCC, ♂). Here, we compared the orthologous genes in the liver transcriptomes of hybrids with those of WCC and RCC, and classified the orthologous genes into eight gene patterns within three categories (chimera, mutant, and biparental origin genes)...
June 13, 2018: Science China. Life Sciences
Wei Li, Jingwen Yu, Zixin Li, Wen-Bing Yin
Laccases, multicopper oxidoreductases, are mainly produced in white-rot fungi and are considered as ideal green catalysts in industrial and biotechnological applications. However, the development of laccases is limited due to the slow growth of natural laccase producing strains and the low expression levels of laccases. In this study, we designed three regulation strategies for laccase gene expression in the model fungus Aspergillus nidulans. By introducing various promoters in front of the laccase gene pslcc from the white-rot fungus Pycnoporus sanguineus, we found that the laccase gene with the original promoter had effective expression in A...
June 12, 2018: Science China. Life Sciences
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