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Science China. Life Sciences

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https://www.readbyqxmd.com/read/28616808/crop-3d-a-lidar-based-platform-for-3d-high-throughput-crop-phenotyping
#1
Qinghua Guo, Fangfang Wu, Shuxin Pang, Xiaoqian Zhao, Linhai Chen, Jin Liu, Baolin Xue, Guangcai Xu, Le Li, Haichun Jing, Chengcai Chu
With the growing population and the reducing arable land, breeding has been considered as an effective way to solve the food crisis. As an important part in breeding, high-throughput phenotyping can accelerate the breeding process effectively. Light detection and ranging (LiDAR) is an active remote sensing technology that is capable of acquiring three-dimensional (3D) data accurately, and has a great potential in crop phenotyping. Given that crop phenotyping based on LiDAR technology is not common in China, we developed a high-throughput crop phenotyping platform, named Crop 3D, which integrated LiDAR sensor, high-resolution camera, thermal camera and hyperspectral imager...
December 6, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28812299/conversion-of-the-high-yield-salinomycin-producer-streptomyces-albus-bk3-25-into-a-surrogate-host-for-polyketide-production
#2
Xiaojie Zhang, Chenyang Lu, Linquan Bai
An ideal surrogate host for heterologous production of various natural products is expected to have efficient nutrient utilization, fast growth, abundant precursors and energy supply, and a pronounced gene expression. Streptomyces albus BK3-25 is a high-yield industrial strain producing type-I polyketide salinomycin, with a unique ability of bean oil utilization. Its potential of being a surrogate host for heterologous production of PKS was engineered and evaluated herein. Firstly, introduction of a three-gene cassette for the biosynthesis of ethylmalonyl-CoA resulted in accumulation of ethylmalonyl-CoA precursor and salinomycin, and subsequent deletion of the salinomycin biosynthetic gene cluster resulted in a host with rich supplies of common polyketide precursors, including malonyl-CoA, methylmalonyl-CoA, and ethylmalonyl-CoA...
August 14, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28812298/a-gata-type-transcription-factor-acareb-for-nitrogen-metabolism-is-involved-in-regulation-of-cephalosporin-biosynthesis-in-acremonium-chrysogenum
#3
Feifei Guan, Yuanyuan Pan, Jinyang Li, Gang Liu
In filamentous fungi, nitrogen metabolism is repressed by GATA-type zinc finger transcription factors. Nitrogen metabolite repression has been found to affect antibiotic production, but the mechanism is still poorly understood. AcareB, encoding a homologue of fungal GATA-type regulatory protein, was cloned from Acremonium chrysogenum. Gene disruption and genetic complementation demonstrated that AcareB plays a key role in utilization of ammonium, glutamine and urea. In addition, significant reduction of cephalosporin production in the AcareB disruption mutant indicated that AcareB is important for cephalosporin production...
August 14, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28812297/neomycin-biosynthesis-is-regulated-positively-by-afsa-g-and-neor-in-streptomyces-fradiae-cgmcc-4-7387
#4
Xiangxi Meng, Wenzhao Wang, Zhoujie Xie, Pengwei Li, Yue Li, Zhengyan Guo, Yingjian Lu, Jie Yang, Kaile Guan, Zhaoxin Lu, Huarong Tan, Yihua Chen
Neomycins are a group of aminoglycoside antibiotics with both clinical and agricultural applications. To elucidate the regulatory mechanism of neomycin biosynthesis, we completed draft genome sequencing of a neomycin producer Streptomyces fradiae CGMCC 4.7387 from marine sediments, and the neomycin biosynthesis gene cluster was identified. Inactivation of the afsA-g gene encoding a γ-butyrolactone (GBL) synthase in S. fradiae CGMCC 4.7387 resulted in a significant decrease of neomycin production. Quantitative RT-PCR analysis revealed that the transcriptional level of neoR and the aphA-neoGH operon were reduced in the afsA-g::aac(3)IV mutant...
August 14, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28812296/mxr7-facilitates-liver-cancer-metastasis-via-epithelial-mesenchymal-transition
#5
Guishuai Lv, Yexiong Tan, Hongwei Lv, Tian Fang, Changzheng Wang, Ting Li, Yanting Yu, Congli Hu, Wen Wen, Hongyang Wang, Wen Yang
MXR7 is a cell-surface protein and highly expressed in hepatocellular carcinoma (HCC). The aim of this study is to determine the expression profile of MXR7 in HCC and investigate the influence of MXR7 on invasion and metastasis of HCC cells. For this purpose, immunohistochemical assay was used to identify the differential expression of MXR7 in 94 HCC specimens. Expression of MXR7 in 4 pairs of HCC and portal vein tumor thrombus (PVTT) was also tested. The motility of HCC cells were characterized by transwell migration and matrigel invasion assays...
August 11, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28801861/human-piwi-hiwi-is-an-azoospermia-factor
#6
Hidetoshi Hasuwa, Kyoko Ishino, Haruhiko Siomi
No abstract text is available yet for this article.
August 10, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28801860/towards-a-one-stop-solution-for-large-scale-proteomics-data-analysis
#7
Yi Zhu, Tiannan Guo
No abstract text is available yet for this article.
August 10, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28801859/cross-cultural-adaption-and-psychometric-properties-of-the-chinese-version-of-the-diabetes-behavior-rating-scale-a-pilot-study
#8
Jing Zhu, Jingjing Xu, Yang Chen, Yong Gu, Li Ji, Yufeng Zhou, Min Zhu, Hsiang-Ting Hsu, Xiaoping Huang, Cuiping Yuan, Yun Shi, Dan Yan, Lili Xie, Shuang Chen, Tao Yang, Wei He
Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus (T1DM). The Diabetes Behavior Rating Scale (DBRS) has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation...
August 10, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28795376/arabidopsis-prk6-interacts-specifically-with-atropgef8-12-and-induces-depolarized-growth-of-pollen-tubes-when-overexpressed
#9
Yuexuan Yu, Jiali Song, Xiaohui Tian, Haiwen Zhang, Legong Li, Huifen Zhu
The pollen receptor kinases (PRK) are critical regulators of pollen tube growth. The Arabidopsis genome encodes eight PRK genes, of which six are highly expressed in pollen tubes. The potential functions of AtPRK1 through AtPRK5, but not of AtPRK6, in pollen growth were analyzed in tobacco. Herein, AtPRK6 was cloned, and its function was identified. AtPRK6 was expressed specifically in pollen tubes. A yeast two-hybrid screen of AtPRK6 against 14 Arabidopsis Rop guanine nucleotide exchange factors (RopGEFs) showed that AtPRK6 interacted with AtRopGEF8 and AtRopGEF12...
August 8, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28795375/evolutionary-significance-of-selected-edar-variants-in-tibetan-high-altitude-adaptations
#10
Jianming Shao, Muhammad Sohail Raza, Basang Zhuoma, Changqing Zeng
Humans have been exposed to many environmental challenges since their evolutionary origins in Africa and subsequent migrations to the rest of the world. A severe environmental challenge to human migrants was hypoxia caused by low barometric oxygen pressure at high altitudes. Several genome-wide scans have elucidated the genetic basis of human high-altitude adaptations. However, the dearth of functional variant information has led to the successful association of only a few candidate genes. In the present study, we employed a candidate gene approach and re-sequenced the EDAR locus in 45 Tibetan individuals to identify mutations involved in hypoxia adaptation...
August 8, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28791589/manipulation-of-biotic-signaling-a-new-theory-for-smarter-pest-control
#11
EDITORIAL
Wei Qian, Xiaoya Chen, Rongxiang Fang, Le Kang
No abstract text is available yet for this article.
August 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28791588/a-prospective-study-scope-comparing-the-cardiometabolic-and-respiratory-effects-of-air-pollution-exposure-on-healthy-and-pre-diabetic-individuals
#12
Yanwen Wang, Yiqun Han, Tong Zhu, Weiju Li, Hongyin Zhang
Air pollution is known to be a major risk factor for cardiopulmonary disease, but this is unclear for cardiometabolic disease (e.g. diabetes). This is of considerable public health importance, given the nationwide epidemic of diabetes, accompanied by severe air pollution, in China. The evidence so far remained inadequate to answer questions of whether individuals with cardiometabolic dysfunctions are susceptible to air pollution and whether air pollution exacerbates diabetes development via certain biological pathways...
August 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28785951/effect-of-elevated-co2-and-o3-on-phytohormone-mediated-plant-resistance-to-vector-insects-and-insect-borne-plant-viruses
#13
REVIEW
Honggang Guo, Shifan Wan, Feng Ge
Climatic variations are becoming important limiting factors for agriculture productivity, as they not only directly affect the plant net primary productivity but can also modulate the outbreak of plant diseases and pests. Elevated CO2 and O3 are two important climatic factors that have been widely studied before. Elevated CO2 or O3 alters the host plant physiology and affects the vector insects and plant viruses via bottom-up effects of the host plants. Many studies have shown that elevated CO2 or O3 decreases the plant nitrogen content, which modulates the characteristics of vector insects...
August 1, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28785950/metabolic-engineering-of-streptomyces-coelicolor-for-enhanced-prodigiosins-red-production
#14
Panpan Liu, Hong Zhu, Guosong Zheng, Weihong Jiang, Yinhua Lu
Bacterial prodigiosins are red-colored secondary metabolites with multiple activities, such as anticancer, antimalarial and immunosuppressive, which hold great potential for medical applications. In this study, dramatically enhanced prodigiosins (RED) production in Streptomyces coelicolor was achieved by combinatorial metabolic engineering, including inactivation of the repressor gene ohkA, deletion of the actinorhodin (ACT) and calcium-dependent antibiotic (CDA) biosynthetic gene clusters (BGCs) and multi-copy chromosomal integration of the RED BGC...
August 1, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28785949/biosynthesis-and-combinatorial-biosynthesis-of-antifungal-nucleoside-antibiotics
#15
REVIEW
Guoqing Niu, Jiazhen Zheng, Huarong Tan
There is an urgent need for new antifungal agents to treat or combat fungal infection in humans and plants. Antifungal nucleoside antibiotics are an important family of natural products with distinctive structural features. Understanding their biosynthetic machinery is of great importance for the improvement of antibiotics titers. More importantly, it is a requisite for combinatorial biosynthesis to create hybrid nucleoside antibiotics. We herein focus on findings on the natural and designed biosynthesis of this important family of nucleoside antibiotics...
August 1, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28785948/biosynthesis-and-molecular-regulation-of-secondary-metabolites-in-microorganisms
#16
EDITORIAL
Yue Li, Huarong Tan
No abstract text is available yet for this article.
August 1, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28762123/differential-immune-responses-of-monochamus-alternatus-against-symbiotic-and-entomopathogenic-fungi
#17
Wei Zhang, Jie Meng, Jing Ning, Peijun Qin, Jiao Zhou, Zhen Zou, Yanhong Wang, Hong Jiang, Faheem Ahmad, Lilin Zhao, Jianghua Sun
Monochamus alternatus, the main vector beetles of invasive pinewood nematode, has established a symbiotic relationship with a native ectotrophic fungal symbiont, Sporothrix sp. 1, in China. The immune response of M. alternatus to S. sp. 1 in the coexistence of beetles and fungi is, however, unknown. Here, we report that immune responses of M. alternatus pupae to infection caused by ectotrophic symbiotic fungus S. sp. 1 and entomopathogenic fungus Beauveria bassiana differ significantly. The S. sp. 1 did not kill the beetles while B...
July 28, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28756571/developmental-differences-between-a-chinese-and-a-north-american-isolate-of-the-pinewood-nematode-bursaphelenchus-xylophilus-tylenchida-aphelenchoididae-under-laboratory-conditions
#18
LETTER
Shuai Zhang, Jing Ning, Wei Zhang, Christian Salcedo, Lilin Zhao
No abstract text is available yet for this article.
July 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28755302/per-os-infectivity-factors-a-complicated-and-evolutionarily-conserved-entry-machinery-of-baculovirus
#19
REVIEW
Xi Wang, Xiaoping Liu, George Alliwa Makalliwa, Jiang Li, Hualin Wang, Zhihong Hu, Manli Wang
Baculoviruses are a family of arthropod-specific large DNA viruses that infect insect species belonging to the orders Lepidoptera, Hymenoptera and Diptera. In nature, occlusion-derived viruses (ODVs) initiate baculovirus primary infection in the midgut epithelium of insect hosts, and this process is largely dependent on a number of ODV envelope proteins designated as per os infectivity factors (PIFs). Interestingly, PIF homologs are also present in other invertebrate large DNA viruses, which is indicative that per os infection is an ancient and phylogenetically conserved entry mechanism shared by these viruses...
July 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28755301/complete-genome-sequence-of-a-novel-bacteriophage-infecting-bradyrhizobium-diazoefficiens-usda110
#20
LETTER
Junjie Liu, Hao Yu, Yong Huang, Zhenhua Yu, Guoquan Fan, Jian Jin, Xiaobing Liu, Guanghua Wang
No abstract text is available yet for this article.
July 27, 2017: Science China. Life Sciences
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