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Science China. Life Sciences

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https://www.readbyqxmd.com/read/28074383/poisoning-the-pika-must-protection-of-grasslands-be-at-the-expense-of-biodiversity
#1
Lan Wu, Hao Wang
No abstract text is available yet for this article.
January 10, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28063010/chaetocin-reactivates-the-lytic-replication-of-epstein-barr-virus-from-latency-via-reactive-oxygen-species
#2
Shilun Zhang, Juan Yin, Jiang Zhong
Oxidative stress, regarded as a negative effect of free radicals in vivo, takes place when organisms suffer from harmful stimuli. Some viruses can induce the release of reactive oxygen species (ROS) in infected cells, which may be closely related with their pathogenicity. In this report, chaetocin, a fungal metabolite reported to have antimicrobial and cytostatic activity, was studied for its effect on the activation of latent Epstein-Barr virus (EBV) in B95-8 cells. We found that chaetocin remarkably up-regulated EBV lytic transcription and DNA replication at a low concentration (50 nmol L(-1))...
January 5, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28063009/dna-methylation-signatures-in-circulating-cell-free-dna-as-biomarkers-for-the-early-detection-of-cancer
#3
REVIEW
Junyun Wang, Xiao Han, Yingli Sun
Detecting cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) in plasma or serum could serve as a "liquid biopsy", which would be useful for numerous diagnostic applications. cfDNA methylation detection is one of the most promising approaches for cancer risk assessment. Here, we reviewed the literature related to the use of serum or plasma circulating cell-free DNA for cancer diagnosis in the early stage and their power as future biomarkers.
January 5, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28083722/will-cancer-cells-be-defeated-by-sodium-bicarbonate
#4
Hongtao Zhang
No abstract text is available yet for this article.
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078512/the-role-of-apparent-diffusion-coefficient-values-in-characterization-of-solid-focal-liver-lesions-a-prospective-and-comparative-clinical-study
#5
Dawei Yang, Jie Zhang, Dan Han, Erhu Jin, Zhenghan Yang
We evaluated and compared the diagnostic accuracy (DA) of apparent diffusion coefficient (ADC) values with that of lesion-to-liver ADC ratios in the characterization of solid focal liver lesions (FLLs). This prospective study was approved by the Institutional Human Ethics Board, after waiving written informed consent. Diffusion-weighted imaging and other routine magnetic resonance imaging were performed on 142 consecutive patients with suspected liver disease. The mean ADC values and lesion-to-liver ADC ratios were compared between benign and malignant solid FLLs...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078511/intra-individual-comparison-of-different-gadolinium-based-contrast-agents-in-the-quantitative-evaluation-of-c6-glioma-with-dynamic-contrast-enhanced-magnetic-resonance-imaging
#6
Ying Li, Gang Liu, Xin Lou, Zhiye Chen, Lin Ma
This experiment aimed to compare the ionic (Gadodiamide, Gd-DTPA-BMA) and non-ionic (Gadopentetate dimeglumine, Gd-DTPA) gadolinium-based contrast agents (GBCA) in the quantitative evaluation of C6 glioma with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A C6 glioma model was established in 12 Wistar rats, and magnetic resonance (MR) scans were performed six days after tumor implantation. Imaging was performed using a 3.0-T MR scanner with a 7-inch handmade circular coil. Pre-contrast T1 mapping and dynamic contrast-enhanced T1WI after a bolus injection (0...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078510/relationship-between-framingham-risk-score-and-subclinical-atherosclerosis-in-carotid-plaques-an-in-vivo-study-using-multi-contrast-mri
#7
Feiyu Li, Xiaoying Wang
The assessment and management of early-stage atherosclerosis are important for the prevention of cardiovascular disease (CVD). In this study, we used multi-contrast magnetic resonance imaging (MRI) to investigate the carotid plaque feature in asymptomatic, at-risk subjects; we also evaluated the correlation between MRI findings and Framingham risk score (FRS). One hundred sixty-six asymptomatic individuals with risk factors for CVD underwent multi-contrast MRI. After the arterial morphology and plaque components were outlined, the differences in carotid plaque burden among the various risk categories were analyzed...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078509/psg9-promotes-angiogenesis-by-stimulating-vegfa-production-and-is-associated-with-poor-prognosis-in-hepatocellular-carcinoma
#8
Weiqi Rong, Lei Yang, Liyuan Yin, Yanning Gao, Ting Xiao, Shujun Cheng
Hepatocellular carcinoma (HCC) is a common malignant solid tumor characterized by rich vascularization. Pregnancy-specific glycoprotein 9 (PSG9) is a member of the carcinoembryonic antigen (CEA)/PSG family and is produced at high levels during pregnancy. We previously identified PSG9 as an HCC-related protein. However, the expression of PSG9 and its regulation during HCC carcinogenesis remain poorly explored. In the present study, we first found that the levels of PSG9 protein were significantly increased in the plasma of HCC patients...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078508/prioritization-of-liver-mri-for-distinguishing-focal-lesions
#9
Qinghua Su, Shusheng Bi, Xuedong Yang
Liver cancer is one of the leading causes of cancer-related mortality worldwide. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that is often used by radiologists for diagnosis and surgical planning. Analysis of a large amount of liver MRI data for each patient limits the radiologist's efficiency and may lead to misdiagnoses. The redundant MRI data, especially from dynamic contrast enhanced (DCE) sequences, is also a bottleneck in transmitting the images via the internet or PACS for remote consultancy in a reasonable amount of time...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078507/quantitative-analysis-of-diffusion-weighted-magnetic-resonance-images-differentiation-between-prostate-cancer-and-normal-tissue-based-on-a-computer-aided-diagnosis-system
#10
Ge Gao, Chengyan Wang, Xiaodong Zhang, Juan Hu, Xuedong Yang, He Wang, Jue Zhang, Xiaoying Wang
Diffusion-weighted imaging (DWI) is considered to be one of the dominant modalities used in prostate cancer (PCa) detection and the assessment of lesion aggressiveness, especially for peripheral zone (PZ) PCa. Computer-aided diagnosis (CAD), which is capable of automatically extracting and evaluating image features, can integrate multiple parameters and improve the detection of PCa. In this study, 13 quantitative image features were extracted from DWI by CAD, and diagnostic efficacy was analyzed in both the PZ and transition zone (TZ)...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078506/regulation-of-p53-acetylation
#11
Wei-Guo Zhu
No abstract text is available yet for this article.
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28078505/t2-relaxation-time-measurements-in-the-brains-of-scalded-rats
#12
Tao Jiang, Liqi Xie, Xin Lou, Dawei Li, Zhiye Chen, Huafeng Xiao, Lin Ma
This study aimed to evaluate the T2 relaxation time of the brain in severely scalded rats using a magnetic resonance (MR) T2 mapping sequence, and to investigate the correlation between T2 relaxation time and plasma glucose level. Twenty-eight Wistar rats were randomly divided into the scalded group (n=21) and control group (n=7). Magnetic resonance scans were performed with T1WI, T2WI, and T2-mapping sequences in the scalded group; the scans were performed 1 day prior to scalding and 1, 3, 5, and 7 days post-scalding; in addition, identical MR scans were performed in the control group at the same time points...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28058635/magnetic-resonance-imaging-in-personalized-medicine
#13
EDITORIAL
Xiaoying Wang, Xiaohong Joe Zhou
No abstract text is available yet for this article.
January 3, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28008554/estimation-of-stature-by-using-the-dimensions-of-the-right-hand-and-right-foot-in-han-chinese-adults
#14
Xinghua Zhang, Yu Wei, Lianbin Zheng, Keli Yu, Dapeng Zhao, Jinping Bao, Yonglan Li, Shunhua Lu, Huanjiu Xi, Guochang Xu, Youfeng Wen
The Han Chinese people are the main ethnic group in China and the largest ethnic group in the world. The dimensions of the hands and feet have been successfully used for the estimation of stature. A total of 26,927 healthy adult subjects, comprising 13,221 men and 13,706 women, were recruited. The survey samples were chosen through random cluster sampling. The mean values were significantly higher in men than those in women for all measurements (P<0.001). All the measurements showed a statistically significant correlation with stature (P<0...
December 21, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/28025761/npr1-dependent-salicylic-acid-signaling-inhibits-agrobacterium-mediated-transient-expression-in-arabidopsis
#15
LETTER
Wenliu Zhu, Xiaotong Hu, Chongyang Wang, Shunping Yan
No abstract text is available yet for this article.
December 20, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/28000018/branching-out
#16
Xin Fang, Xiao-Ya Chen
No abstract text is available yet for this article.
December 19, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/28000017/high-throughput-development-of-genome-wide-locus-specific-informative-ssr-markers-in-wheat
#17
LETTER
Lei Li, Fayu Sun, Di Wu, Fei Zhen, Guihua Bai, Derong Gao, Tao Li
No abstract text is available yet for this article.
December 16, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27975163/profile-of-peng-li
#18
(no author information available yet)
No abstract text is available yet for this article.
December 15, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27981432/the-size-matters-regulation-of-lipid-storage-by-lipid-droplet-dynamics
#19
REVIEW
Jinhai Yu, Peng Li
Adequate energy storage is essential for sustaining healthy life. Lipid droplet (LD) is the subcellular organelle that stores energy in the form of neutral lipids and releases fatty acids under energy deficient conditions. Energy storage capacity of LDs is primarily dependent on the sizes of LDs. Enlargement and growth of LDs is controlled by two molecular pathways: neutral lipid synthesis and atypical LD fusion. Shrinkage of LDs is mediated by the degradation of neutral lipids under energy demanding conditions and is controlled by neutral cytosolic lipases and lysosomal acidic lipases...
December 13, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27975164/variants-of-genes-encoding-collagens-and-matrix-metalloproteinase-system-increased-the-risk-of-aortic-dissection
#20
Zongzhe Li, Chengming Zhou, Lun Tan, Peng Chen, Yanyan Cao, Chenze Li, Xianqing Li, Jiangtao Yan, Hesong Zeng, Dao-Wu Wang, Dao-Wen Wang
Aortic dissection (AD) is a devastating, heterogeneous condition of aorta. The homeostasis between collagens and matrix metalloproteases (MMPs)/tissue inhibitors of MMPs (TIMPs) system in the extracellular matrix plays an important role for structure and functions of aorta. However, our knowledge on association between variants of genes in this system and pathogenesis of AD is very limited. We analyzed all yet known coding human genes of collagens (45 genes), MMPs/TIMPs (27 genes) in 702 sporadic AD patients and in 163 matched healthy controls, by using massively targeted next-generation and Sanger sequencing...
December 13, 2016: Science China. Life Sciences
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