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Science China. Life Sciences

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https://www.readbyqxmd.com/read/28321657/novel-hemostatic-agents-based-on-gelatin-microbial-transglutaminase-mix
#1
Fang Lv, Xiaonan Cong, Wenshu Tang, Yiming Han, Yu Tang, Yongrui Liu, Liqiang Su, Mingyao Liu, Mingfei Jin, Zhengfang Yi
Hemostasis is a major challenge in surgical procedures and traumas. Conventional hemostatic methods have limited efficacy and may cause additional tissue damage. In this study, we designed a novel hemostatic agent based on the in situ gel formation of gelatin cross-linked by a novel microbial transglutaminase (mTGase), in which the amino acid sequences differed from commercial mTGases. The new hemostatic agent showed the same biochemical crosslinking chemistry as the final stages of the blood coagulation cascade while using gelatin as a "structural" protein (rather than fibrin) and a calcium-independent mTGase as the crosslinking catalyst (rather than factor XIIIa)...
March 17, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28303459/crispr-cas9-mediated-base-editing-system-efficiently-generates-gain-of-function-mutations-in-arabidopsis
#2
LETTER
Yiyu Chen, Zhiping Wang, Hanwen Ni, Yong Xu, Qijun Chen, Linjian Jiang
No abstract text is available yet for this article.
March 16, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28299578/future-science-prize-goes-to-non-invasive-prenatal-testing
#3
Kang Li, Yaou Duan, Magdalene Yin Lin Ting, Zhiying Ou, Li Liu, Kang Zhang, Xin Fu
No abstract text is available yet for this article.
March 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28299577/a-novel-strategy-to-generate-virus-vaccines-with-expanded-genetic-codes
#4
Deyin Guo
No abstract text is available yet for this article.
March 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28299576/a-natural-communication-system-on-genome-evolution
#5
Qi Wu, Yadi Wang, Yun Ding, Shuai Ma, Zongmin Wu, Fuwen Wei
No abstract text is available yet for this article.
March 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28299575/phylogenetic-constrains-on-mycorrhizal-specificity-in-eight-dendrobium-orchidaceae-species
#6
Xiaoke Xing, Xueting Ma, Jinxin Men, Yanhong Chen, Shunxing Guo
Plant phylogeny constrains orchid mycorrhizal (OrM) fungal community composition in some orchids. Here, we investigated the structures of the OrM fungal communities of eight Dendrobium species in one niche to determine whether similarities in the OrM fungal communities correlated with the phylogeny of the host plants and whether the Dendrobium-OrM fungal interactions are phylogenetically conserved. A phylogeny based on DNA data was constructed for the eight coexisting Dendrobium species, and the OrM fungal communities were characterized by their roots...
March 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28293812/the-substitution-v379i-in-pa-protein-attenuates-the-pathogenicity-of-influenza-a-h1n1-pdm09-viruses-in-mice
#7
LETTER
Yongkun Chen, Wenfei Zhu, Tian Bai, Xiaohui Zou, Siyu Zhang, Yan Sun, Xiyan Li, Xingyu Xiang, Qinglong Zhao, Chaoyang Huang, Tao Chen, Dayan Wang, Yuelong Shu
No abstract text is available yet for this article.
March 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28260228/a-crispr-cas9-toolkit-for-efficient-targeted-base-editing-to-induce-genetic-variations-in-rice
#8
LETTER
Bin Ren, Fang Yan, Yongjie Kuang, Na Li, Dawei Zhang, Honghui Lin, Huanbin Zhou
No abstract text is available yet for this article.
March 3, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28251462/genetic-technologies-for-extremely-thermophilic-microorganisms-of-sulfolobus-the-only-genetically-tractable-genus-of-crenarchaea
#9
REVIEW
Nan Peng, Wenyuan Han, Yingjun Li, Yunxiang Liang, Qunxin She
Archaea represents the third domain of life, with the information-processing machineries more closely resembling those of eukaryotes than the machineries of the bacterial counterparts but sharing metabolic pathways with organisms of Bacteria, the sister prokaryotic phylum. Archaeal organisms also possess unique features as revealed by genomics and genome comparisons and by biochemical characterization of prominent enzymes. Nevertheless, diverse genetic tools are required for in vivo experiments to verify these interesting discoveries...
February 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28251461/the-genome-wide-molecular-regulation-of-mouse-gastrulation-embryo
#10
REVIEW
Guangdun Peng, Naihe Jing
The diverse morphologies among vertebrate species stems from the evolution of a basic body plan that is constituted by a spatially organized ensemble of tissue lineage progenitors. At gastrulation, this body plan is established through a coordinated morphogenetic process and the delineation of tissue lineages that are driven by the activity of the genome. To explore the molecular mechanisms, in a comprehensive context, it is imperative to glean an understanding of the region- and population-specific genetic activity underpinning this fundamental developmental process...
February 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28251460/characterization-of-a-disease-susceptibility-locus-for-exploring-an-efficient-way-to-improve-rice-resistance-against-bacterial-blight
#11
Qi Cheng, Weihua Mao, Wenya Xie, Qinsong Liu, Jianbo Cao, Meng Yuan, Qinglu Zhang, Xianghua Li, Shiping Wang
Bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is the most harmful bacterial disease of rice worldwide. Previously, we characterized major disease resistance (MR) gene xa25, which confers race-specific resistance to Xoo strain PXO339. The xa25 is a recessive allele of the SWEET13 locus, but SWEET13's interaction with PXO339 and how efficiently using this locus for rice breeding still need to be defined. Here we show that the SWEET13 allele from rice Zhenshan 97 is a susceptibility gene to PXO339...
February 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28251459/lycorine-inhibits-breast-cancer-growth-and-metastasis-via-inducing-apoptosis-and-blocking-src-fak-involved-pathway
#12
Xuexiang Ying, Anling Huang, Yajing Xing, Liping Lan, Zhengfang Yi, Pingqing He
Breast cancer is the most commonly diagnosed cancer type worldwide among women and more than 90% of patients die from tumor metastasis. Lycorine, a natural alkaloid, has been widely reported possessing potential efficacy against cancer proliferation and metastasis. In our study, the anti-tumor potency on breast cancer was evaluated in vitro and in vivo for the first time. Our results indicated that lycorine inhibited breast cancer cells growth, migration and invasion as well as induced their apoptosis. In in vivo study, lycorine not only suppressed breast tumor growth in xenograft models and inhibited breast tumor metastasis in MDA-MB-231 tail vein model...
February 27, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28271252/what-strategies-are-implied-by-strategy
#13
Zachary Bloomgarden
No abstract text is available yet for this article.
February 26, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28215028/ten-years-of-achievements-in-biological-and-medical-sciences
#14
EDITORIAL
Mingyao Liu, Tieliu Shi
No abstract text is available yet for this article.
February 18, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28194553/acidic-domains-differentially-read-histone-h3-lysine-4-methylation-status-and-are-widely-present-in-chromatin-associated-proteins
#15
Meng Wu, Wei Wei, Jiwei Chen, Rong Cong, Tieliu Shi, Jiwen Li, Jiemin Wong, James X Du
Histone methylation is believed to provide binding sites for specific reader proteins, which translate histone code into biological function. Here we show that a family of acidic domain-containing proteins including nucleophosmin (NPM1), pp32, SET/TAF1β, nucleolin (NCL) and upstream binding factor (UBF) are novel H3K4me2-binding proteins. These proteins exhibit a unique pattern of interaction with methylated H3K4, as their binding is stimulated by H3K4me2 and inhibited by H3K4me1 and H3K4me3. These proteins contain one or more acidic domains consisting mainly of aspartic and/or glutamic residues that are necessary for preferential binding of H3K4me2...
February 13, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28271251/efficacy-and-safety-of-metformin-and-sitagliptin-based-triple-antihyperglycemic-therapy-strategy-a-multicenter-randomized-controlled-non-inferiority-clinical-trial
#16
Wen Xu, Yiming Mu, Jiajun Zhao, Dalong Zhu, Qiuhe Ji, Zhiguang Zhou, Bin Yao, Anhua Mao, Samuel S Engel, Bin Zhao, Yan Bi, Longyi Zeng, Xingwu Ran, Juming Lu, Linong Ji, Wenying Yang, Weiping Jia, Jianping Weng
Despite the current guideline's recommendation of a timely stepwise intensification therapy, the "clinical inertia", termed as the delayed treatment intensification, commonly exists in the real world, which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy. In this clinical trial performed in 237 centers in China, 5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks...
February 7, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28120269/presenilin-2-deficiency-facilitates-a%C3%AE-induced-neuroinflammation-and-injury-by-upregulating-p2x7-expression
#17
Juliang Qin, Xiaoyu Zhang, Ziqiang Wang, Jinju Li, Zhen Zhang, Liangcai Gao, Hua Ren, Min Qian, Bing Du
Accumulating evidence suggests that β-amyloid (Aβ)-induced neuroinflammation plays a prominent and early role in Alzheimer's disease (AD). In this study, we demonstrated that Presenilin 2 (PS2) deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 expression both in vitro and in vivo. PS2 knockout mice demonstrated increased cognitive impairments and cerebral injury. PS2 deficiency increased the expression of P2X7 both in neurons and microglial cells. Furthermore, extracellular ATP also increased in both Aβ-treated and untreated PS2 knockout microglial cells...
January 23, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28120268/long-non-coding-rnas-play-an-important-role-in-regulating-photoperiod-and-temperature-sensitive-male-sterility-in-rice
#18
Jingxin Guo, Yao-Guang Liu
No abstract text is available yet for this article.
January 23, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28120267/competition-between-toxic-and-nontoxic-microcystis-cyanophyceae-under-different-light-and-temperature-conditions
#19
LETTER
Yinxia Li, Yiwen Wu, Bibo Liu, Dunhai Li
No abstract text is available yet for this article.
January 22, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28120266/identification-of-twist-interacting-genes-in-prostate-cancer
#20
Peng Lyu, Shu-Dong Zhang, Hiu-Fung Yuen, Cian M McCrudden, Qing Wen, Kwok-Wah Chan, Hang Fai Kwok
Prostate cancer is one of the most common cancers in men worldwide, and the number of diagnosed patients has dramatically increased in recent years. Currently, the clinical parameters used to diagnose prostate cancer, such as Gleason score, pathological tumor staging, and prostate-specific antigen (PSA) expression level, are considered insufficient to inform recommendation to guide clinical practice. Thus, identification of a novel biomarker is necessary. TWIST is one of the well-studied targets and is correlated with cancer invasion and metastasis in several human cancers...
January 22, 2017: Science China. Life Sciences
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