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Science China. Life Sciences

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https://www.readbyqxmd.com/read/27921234/simultaneous-virus-identification-and-characterization-of-severe-unexplained-pneumonia-cases-using-a-metagenomics-sequencing-technique
#1
Xiaohui Zou, Guangpeng Tang, Xiang Zhao, Yan Huang, Tao Chen, Mingyu Lei, Wenbing Chen, Lei Yang, Wenfei Zhu, Li Zhuang, Jing Yang, Zhaomin Feng, Dayan Wang, Dingming Wang, Yuelong Shu
Many viruses can cause respiratory diseases in humans. Although great advances have been achieved in methods of diagnosis, it remains challenging to identify pathogens in unexplained pneumonia (UP) cases. In this study, we applied next-generation sequencing (NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province, China. A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS. An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples...
December 2, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27921233/in-vivo-calcium-imaging-and-parkinson-s-disease
#2
Tianwen Huang, Qinyong Ye
No abstract text is available yet for this article.
December 2, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27921236/root-morphology-in-response-to-nitrogen-supply-in-mid-season-indica-rice-cultivars-released-in-different-decades
#3
LETTER
Yikai Zhang, Huizhe Chen, Yuping Zhang, Jing Xiang, Guangmei Ji, Defeng Zhu
No abstract text is available yet for this article.
December 1, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27921235/transplantation-of-collagen-scaffold-with-autologous-bone-marrow-mononuclear-cells-promotes-functional-endometrium-reconstruction-via-downregulating-%C3%AE-np63-expression-in-asherman-s-syndrome
#4
Guangfeng Zhao, Yun Cao, Xianghong Zhu, Xiaoqiu Tang, Lijun Ding, Haixiang Sun, Juan Li, Xinan Li, Chenyan Dai, Tong Ru, Hui Zhu, Jingjie Lu, Caimei Lin, Jingmei Wang, Guijun Yan, Huiyan Wang, Lei Wang, Yimin Dai, Bin Wang, Ruotian Li, Jianwu Dai, Yan Zhou, Yali Hu
Asherman's syndrome (AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells (BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration...
December 1, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27909848/tissue-resident-natural-killer-cells-in-the-livers
#5
REVIEW
Hui Peng, Zhigang Tian
Nature killer (NK) cells are important lymphocytes of the innate immune system, well known for their pivotal roles in immune surveillance and defense against tumor and virus-infected cells. Current studies have revealed that NK cells are not a homogeneous population, but instead consist of distinct subsets with diverse characteristics. As an organ with predominant innate immunity, the liver is enriched with NK cells, among which two distinct NK cell subsets have recently been identified: conventional NK (cNK) cells and tissue-resident NK (trNK) cells...
November 30, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27909847/dynamic-microenvironment-and-multiple-damaged-tissue-regeneration-in-a-de-novo-and-synchronized-manner
#6
Biao Cheng, Xiaobing Fu
No abstract text is available yet for this article.
November 30, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27905000/decidual-natural-killer-cells-and-the-immune-microenvironment-at-the-maternal-fetal-interface
#7
REVIEW
Binqing Fu, Haiming Wei
During early pregnancy, an orchestrated evolutionary maternal adaption toward tolerance of the semiallogeneic fetus is required to ensure decidualization and early embryo development. Remodeling of the immune system involves natural killer cells (NKs), macrophages, T cells and dendritic cells (DCs) altering the microenvironment in the deciduas. In particular, a unique population of NK cells with a CD56(bright)CD16(-) phenotype in the decidua has been proposed to play a key role in the maternal adaptation to pregnancy...
November 29, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27904999/from-the-first-human-gene-editing-to-the-birth-of-three-parent-baby
#8
Xiaoxue Zhang, Si Wang
No abstract text is available yet for this article.
November 29, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27888388/cardiac-bin1-cbin1-is-a-regulator-of-cardiac-contractile-function-and-an-emerging-biomarker-of-heart-muscle-health
#9
REVIEW
Kang Zhou, Tingting Hong
In recent decades, a cardiomyocyte membrane scaffolding protein bridging integrator 1 (BIN1) has emerged as a critical multifunctional regulator of transverse-tubule (t-tubule) function and calcium signaling in cardiomyocytes. Encoded by a single gene with 20 exons that are alternatively spliced, more than ten BIN1 protein isoforms are expressed with tissue and disease specificity. The recently discovered cardiac alternatively spliced isoform BIN1 (cBIN1 or BIN1+13+17) plays a crucial role in organizing membrane microfolds within cardiac t-tubules...
November 23, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27888387/incubation-experiment-demonstrates-effects-of-carbon-and-nitrogen-on-microbial-phosphate-solubilizing-function
#10
LETTER
Hongyang Sun, Yanhong Wu, Jun Zhou, Haijian Bing
No abstract text is available yet for this article.
November 23, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27888386/innate-recognition-of-microbial-derived-signals-in-immunity-and-inflammation
#11
REVIEW
Yue Zhang, Chunli Liang
Microbes generate a vast array of different types of conserved structural components called pathogen-associated molecular patterns (PAMPs), which can be recognized by cells of the innate immune system. This recognition of "nonself" signatures occurs through host pattern recognition receptors (PRRs), suggesting that microbial-derived signals are good targets for innate immunity to discriminate between self- and nonself. Such PAMP-PRR interactions trigger multiple but distinct downstream signaling cascades, subsequently leading to production of proinflammatory cytokines and interferons that tailor immune responses to particular microbes...
November 23, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27888385/targeting-spop-with-small-molecules-provides-a-novel-strategy-for-kidney-cancer-therapy
#12
Tong Zheng, Cai-Guang Yang
No abstract text is available yet for this article.
November 23, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27888384/exploiting-histone-deacetylases-for-cancer-therapy-from-hematological-malignancies-to-solid-tumors
#13
Min Huang, Meiyu Geng
No abstract text is available yet for this article.
November 23, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27864711/mesenchymal-stem-cells-derived-exosomal-micrornas-contribute-to-wound-inflammation
#14
REVIEW
Dongdong Ti, Haojie Hao, Xiaobing Fu, Weidong Han
Clinical and experimental studies have highlighted the significance of inflammation in coordinating wound repair and regeneration. However, it remains challenging to control the inflammatory response and tolerance at systemic levels without causing toxicity to injured tissues. Mesenchymal stem cells (MSCs) possess potent immunomodulatory properties and facilitate tissue repair by releasing exosomes, which generate a suitable microenvironment for inflammatory resolution. Exosomes contain several effective bioactive molecules and act as a cell-cell communication vehicle to influence cellular activities in recipient cells...
November 18, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27864710/regulation-of-sporopollenin-synthesis-for-pollen-wall-formation-in-plant
#15
Zhong-Nan Yang
No abstract text is available yet for this article.
November 17, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27858336/sirtuin-5-a-review-of-structure-known-inhibitors-and-clues-for-developing-new-inhibitors
#16
REVIEW
Lingling Yang, Xiaobo Ma, Yanying He, Chen Yuan, Quanlong Chen, Guobo Li, Xianggui Chen
Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases, which regulate important biological processes ranging from apoptosis, age-associated pathophysiologies, adipocyte and muscle differentiation, and energy expenditure to gluconeogenesis. Very recently, sirtuin 5 (SIRT5) has received considerable attention due to that it was found to have weak deacetylase activity but strong desuccinylase, demalonylase and deglutarylase activities, and it was also found to be associated with several human diseases such as cancer, Alzheimer's disease, and Parkinson's disease...
November 17, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27858335/golm1-regulated-egfr-rtk-recycling-is-a-novel-target-for-combating-hcc-metastasis
#17
Wenwei Zhu, Lunxiu Qin
No abstract text is available yet for this article.
November 17, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27858334/identification-of-medaka-magnetoreceptor-and-cryptochromes
#18
Yunzhi Wang, Jianbin Chen, Feng Zhu, Yunhan Hong
Magnetoreception is a hallmark ability of animals for orientation and migration via sensing and utilizing geomagnetic fields. Magnetoreceptor (MagR) and cryptochromes (Cry) have recently been identified as the basis for magnetoreception in Drosophila. However, it has remained unknown whether MagR and Cry have conserved roles in diverse animals. Here we report the identification and expression of magr and cry genes in the fish medaka (Oryzias latipes). Cloning and sequencing identified a single magr gene, four cry genes and one cry-like gene in medaka...
November 17, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27837403/interplay-of-transcription-factors-and-micrornas-during-embryonic-hematopoiesis
#19
Xueping Gong, Ruihua Chao, Pengxiang Wang, Xiaoli Huang, Jingjing Zhang, Xiaozhou Zhu, Yanyang Zhang, Xue Yang, Chao Hou, Xiangjun Ji, Tieliu Shi, Yuan Wang
Hematopoietic stem cells (HSCs), which are localized in the bone marrow of adult mammals, come from hematopoietic endothelium during embryonic stages. Although the basic processes of HSC generation and differentiation have been described in the past, the epigenetic regulation of embryonic hematopoiesis remains to be fully described. Here, by utilizing an in vitro differentiation system of mouse embryonic stem cells (ESCs), we identified more than 20 microRNAs that were highly enriched in embryonic hematopoietic cells, including some (e...
November 9, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27837402/adipose-tissue-macrophage-in-immune-regulation-of-metabolism
#20
REVIEW
Yifu Qiu, Bo Shan, Liu Yang, Yong Liu
The prevalence of obesity and type 2 diabetes is escalating to an epidemic proportion worldwide. Obesity is known to be associated with a state of chronic, low-grade inflammation. Emerging lines of evidence have shown that both innate and adaptive immune responses play crucial roles in the control of metabolic homeostasis. Macrophages in adipose tissues are the essential effector cells in orchestrating metabolic inflammation, which is thought to promote the pathogenic progression of obesity and obesity-related disorders...
November 9, 2016: Science China. Life Sciences
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