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Stroke Research and Treatment

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https://www.readbyqxmd.com/read/29123937/a-systematic-review-of-the-causes-and-management-of-ischaemic-stroke-caused-by-nontissue-emboli
#1
REVIEW
Ciaran Judge, Sarah Mello, David Bradley, Joseph Harbison
Introduction: The inadvertent or purposeful introduction of foreign bodies or substances can lead to cerebral infarction if they embolize to the brain. Individual reports of these events are uncommon but may increase with the increased occurrences of their risk factors, for example, intra-arterial procedures. Method: We searched EMBASE and MEDLINE for articles on embolic stroke of nontissue origin. 1889 articles were identified and screened and 216 articles were ultimately reviewed in full text and included in qualitative analysis...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/29098109/impact-of-spasticity-on-balance-control-during-quiet-standing-in-persons-after-stroke
#2
Reza Rahimzadeh Khiabani, George Mochizuki, Farooq Ismail, Chris Boulias, Chetan P Phadke, William H Gage
Background: Balance impairments, falls, and spasticity are common after stroke, but the effect of spasticity on balance control after stroke is not well understood. Methods: In this cross-sectional study, twenty-seven participants with stroke were divided into two groups, based on ankle plantar flexor spasticity level. Fifteen individuals with high spasticity (Modified Ashworth Scale (MAS) score of ≥2) and 12 individuals with low spasticity (MAS score <2) completed quiet standing trials with eyes open and closed conditions...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/29082062/serum-uric-acid-is-associated-with-poor-outcome-in-black-africans-in-the-acute-phase-of-stroke
#3
Yacouba N Mapoure, Chia Mark Ayeah, M S Doualla, H Ba, Hugo B Mbatchou Ngahane, Salomon Mbahe, Henry N Luma
BACKGROUND: Prognostic significance of serum uric acid (SUA) in acute stroke still remains controversial. OBJECTIVES: To determine the prevalence of hyperuricemia and its association with outcome of stroke patients in the Douala General Hospital (DGH). METHODS: This was a hospital based prospective cohort study which included acute stroke patients with baseline SUA levels and 3-month poststroke follow-up data. Associations between high SUA levels and stroke outcomes were analyzed using multiple logistic regression and survival analysis (Cox regression and Kaplan-Meier)...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28808596/the-severity-of-intracranial-hemorrhages-measured-by-free-hemoglobin-in-the-brain-depends-on-the-anticoagulant-class-experimental-data
#4
Kyle M Ware, Douglas L Feinstein, Israel Rubinstein, Prudhvi Battula, Jose Otero, Lee Hebert, Tzu-Fei Wang, Alexandra Ivanova, Shweta Chaudhary, Jessica Hemminger, Sergey V Brodsky
Background and Purpose. Anticoagulant therapy is broadly used to prevent thromboembolic events. Intracranial hemorrhages are serious complications of anticoagulation, especially with warfarin. Direct oral anticoagulants reduce but do not eliminate the risk of intracranial hemorrhages. The aim of this study is to determine the degree of intracranial hemorrhage after application of anticoagulants without additional triggers. Methods. Rats were treated with different anticoagulant classes (vitamin K antagonists, heparin, direct thrombin inhibitor, and factor Xa inhibitor)...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28717529/daily-variation-in-the-occurrence-of-different-subtypes-of-stroke
#5
Luciana Ripamonti, Roberto Riva, Fabiola Maioli, Corrado Zenesini, Gaetano Procaccianti
Three thousand two hundred and ninety-eight patients admitted to our Stroke Unit with hemorrhagic, large artery atherosclerosis, cardioembolic, small-vessel occlusion, and undetermined etiology-cryptogenic strokes were included in the study. The circadian variability in onset in each stroke subgroup and the associations with various risk factors were analyzed. In each subgroup, a significant minority of patients suffered from stroke during sleep. In the ischemic group, hypercholesterolemia, paroxysmal atrial fibrillation, and previous myocardial infarction facilitated the onset during waking...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28702271/risk-factors-and-etiology-of-young-ischemic-stroke-patients-in-estonia
#6
Siim Schneider, Alina Kornejeva, Riina Vibo, Janika Kõrv
OBJECTIVES: Reports on young patients with ischemic stroke from Eastern Europe have been scarce. This study aimed to assess risk factors and etiology of first-ever and recurrent stroke among young Estonian patients. METHODS: We performed a retrospective study of consecutive ischemic stroke patients aged 18-54 years who were treated in our two hospitals from 2003 to 2012. RESULTS: We identified 741 patients with first-ever stroke and 96 patients with recurrent stroke...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28634570/to-use-or-not-to-use-metformin-in-cerebral-ischemia-a-review-of-the-application-of-metformin-in-stroke-rodents
#7
REVIEW
Isaac Arbeláez-Quintero, Mauricio Palacios
Ischemic strokes are major causes of death and disability. Searching for potential therapeutic strategies to prevent and treat stroke is necessary, given the increase in overall life expectancy. Epidemiological reports indicate that metformin is an oral antidiabetic medication that can reduce the incidence of ischemic events in patients with diabetes mellitus. Its mechanism of action has not been elucidated, but metformin pleiotropic effects involve actions in addition to glycemic control. AMPK activation has been described as one of the pharmacological mechanisms that explain the action of metformin and that lead to neuroprotective effects...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28634569/epidemiology-and-management-of-atrial-fibrillation-and-stroke-review-of-data-from-four-european-countries
#8
REVIEW
Andreea D Ceornodolea, Roland Bal, Johan L Severens
In Europe, 1-3% of the population suffers from atrial fibrillation (AF) and has increased stroke risk. By 2060 a doubling in number of cases and great burden in managing this medical condition are expected. This paper offers an overview of data on epidemiology and management of AF and stroke in four European countries as well as the interconnection between these dimensions. A search index was developed to access multiple scientific and "grey" literatures. Information was prioritised based on strength of evidence and date...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28630782/remote-assessment-of-platelet-function-in-patients-with-acute-stroke-or-transient-ischaemic-attack
#9
Philip M Bath, Jane May, Katie Flaherty, Lisa J Woodhouse, Natalia Dovlatova, Sue C Fox, Timothy J England, Kailash Krishnan, Thompson G Robinson, Nikola Sprigg, Stan Heptinstall, Tardis Investigators
BACKGROUND: The TARDIS trial assessed the safety and efficacy of intensive versus guideline antiplatelet agents given for one month in patients with acute stroke or TIA. The aim of this substudy was to assess the effect of antiplatelet agents taken at baseline on platelet function reactivity and activation. METHODS: Platelet function, assessed by remotely measured surface expression of P-selectin, was assessed in patients at their time of randomisation. Data are median fluorescence values...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28593066/sequence-analysis-of-long-term-readmissions-among-high-impact-users-of-cerebrovascular-patients
#10
Ahsan Rao, Alex Bottle, Ara Darzi, Paul Aylin
OBJECTIVE: Understanding the chronological order of the causes of readmissions may help us assess any repeated chain of events among high-impact users, those with high readmission rate. We aim to perform sequence analysis of administrative data to identify distinct sequences of emergency readmissions among the high-impact users. METHODS: A retrospective cohort of all cerebrovascular patients identified through national administrative data and followed for 4 years...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28536667/association-between-embolic-stroke-patterns-esus-etiology-and-new-diagnosis-of-atrial-fibrillation-a-secondary-data-analysis-of-the-find-af-trial
#11
Ilko L Maier, Katharina Schregel, André Karch, Mark Weber-Krueger, Rafael T Mikolajczyk, Raoul Stahrenberg, Klaus Gröschel, Mathias Bähr, Michael Knauth, Marios-Nikos Psychogios, Rolf Wachter, Jan Liman
Background. Atrial fibrillation (AF) is an important cause of embolic stroke of undetermined source (ESUS). Imaging-patterns like multiple infarcts, simultaneous involvement of different circulations, infarcts of different ages, and isolated cortical infarcts are likely to indicate cardioembolic stroke. The aim of our study was to evaluate the association between embolic stroke patterns, ESUS, and the new diagnosis of AF. Methods. Stroke etiology and imaging characteristics from patients included in the Find-AF study were obtained...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28409051/revisiting-hemicraniectomy-late-decompressive-hemicraniectomy-for-malignant-middle-cerebral-artery-stroke-and-the-role-of-infarct-growth-rate
#12
Saadat Kamran, Naveed Akhtar, Abdul Salam, Ayman Alboudi, Kainat Kamran, Arsalan Ahmed, Rabia A Khan, Mohsin K Mirza, Jihad Inshasi, Ashfaq Shuaib
Objective and Methods. The outcome in late decompressive hemicraniectomy in malignant middle cerebral artery stroke and the optimal timings of surgery has not been addressed by the randomized trials and pooled analysis. Retrospective, multicenter, cross-sectional study to measure outcome following DHC under 48 or over 48 hours using the modified Rankin scale [mRS] and dichotomized as favorable ≤4 or unfavorable >4 at three months. Results. In total, 137 patients underwent DHC. Functional outcome analyzed as mRS 0-4 versus mRS 5-6 showed no difference in this split between early and late operated on patients [P = 0...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28321357/factors-associated-with-poststroke-anxiety-a-systematic-review-and-meta-analysis
#13
REVIEW
Francesca Wright, Simiao Wu, Ho-Yan Yvonne Chun, Gillian Mead
Background and Purpose. Anxiety affects 25% of stroke survivors. There are no effective treatments. Poststroke depression, prestroke anxiety and depression, locus of control, coping, confidence, fatigue, and sleep are factors that may be associated with poststroke anxiety and can potentially be targeted by therapy. We systematically reviewed the literature and performed a meta-analysis to identify associations with these factors. Methods. We searched electronic databases from January 2014 to July 2015 to complement a literature search performed from inception to May 2014...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28251015/brain-symmetry-index-in-healthy-and-stroke-patients-for-assessment-and-prognosis
#14
Andrei Agius Anastasi, Owen Falzon, Kenneth Camilleri, Malcolm Vella, Richard Muscat
Objective. Quantitative neurophysiological signal parameters are of value in predicting motor recovery after stroke. The novel role of EEG-derived brain symmetry index for motor function prognostication in the subacute phase after stroke is explored. Methods. Ten male stroke patients and ten matched healthy controls were recruited. Motor function was first assessed clinically using the MRC score, its derivative Motricity Index, and the Fugl-Meyer assessment score. EEG was subsequently recorded first with subjects at rest and then during hand grasping motions, triggered by visual cues...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28243482/feasibility-of-a-nurse-led-weekend-group-exercise-program-for-people-after-stroke
#15
Katharine Scrivener, Raymond Tourany, Mary McNamara-Holmes, Karl Schurr, Simone Dorsch, Catherine Dean
Background. Additional physical activity including repetitive task practice can improve outcomes after stroke. The additional practice can be facilitated by therapists and family members or could also be delivered by nursing staff. Objective. To investigate the feasibility of a nurse-led weekend exercise program after stroke. Participants. Individuals after stroke, who participated in a weekend exercise program during their hospital admission. Methods. A retrospective audit of the number of referrals to and amount of exercise repetitions achieved in a nurse-led weekend exercise program was undertaken...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28127492/renal-dysfunction-is-an-independent-risk-factor-for-poor-outcome-in-acute-ischemic-stroke-patients-treated-with-intravenous-thrombolysis-a-new-cutoff-value
#16
Elyar Sadeghi-Hokmabadi, Demet Funda Baş, Mehdi Farhoudi, Aliakbar Taheraghdam, Daryoush Savadi Oskouei, Mohammad Yazdchi, Maziyar Hashemilar, Nevzat Uzuner, Reshad Mirnour, Ertugrul Colak, Atilla Özcan Özdemir
Objective. This study was set to assess the effect of renal dysfunction on outcome of stroke patients treated with intravenous thrombolysis (IVT). Methods. This multicenter research involved 403 patients from January 2009 to March 2015. Patients were divided into two groups: (1) control group with GFR ≥ 45 mL/min/1.73 m(2) and (2) low GFR group with GFR < 45 mL/min/1.73 m(2). Outcome measurements were poor outcome (mRS 3-6) and mortality at 3 months and symptomatic intracerebral hemorrhage (SICH) within the first 24-36 hours...
2017: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28116215/thrombin-generation-in-acute-ischaemic-stroke
#17
Ibrahim O Balogun, Lara N Roberts, Raj Patel, Rohan Pathansali, Lalit Kalra, Roopen Arya
Introduction. Stroke remains a global leading cause of death and disability. Traditional description of plasma biology in the aftermath of acute ischaemic stroke favours development of hypercoagulability, resulting from complex interplay between plasma and endothelial factors. However, no single assay measures the overall global coagulation process. We postulate that thrombin generation would assist in identifying coagulation abnormalities after acute stroke. Aim. To investigate the coagulation abnormalities after acute ischaemic stroke using thrombin generation...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28058130/therapists-perspective-on-virtual-reality-training-in-patients-after-stroke-a-qualitative-study-reporting-focus-group-results-from-three-hospitals
#18
Ludwig Schmid, Andrea Glässel, Corina Schuster-Amft
Background. During the past decade, virtual reality (VR) has become a new component in the treatment of patients after stroke. Therefore aims of the study were (a) to get an insight into experiences and expectations of physiotherapists and occupational therapists in using a VR training system and (b) to investigate relevant facilitators, barriers, and risks for implementing VR training in clinical practice. Methods. Three focus groups were conducted with occupational therapists and physiotherapists, specialised in rehabilitation of patients after stroke...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/28050311/variables-that-best-differentiate-in-patient-acute-stroke-from-stroke-mimics-with-acute-neurological-deficits
#19
P Natteru, M R Mohebbi, P George, D Wisco, J Gebel, C R Newey
Introduction. Strokes and stroke-mimics have been extensively studied in the emergency department setting. Although in-hospital strokes are less studied in comparison to strokes in the emergency department, they are a source of significant direct and indirect costs. Differentiating in-hospital strokes from stroke-mimics is important. Thus, our study aimed to identify variables that can differentiate in-hospital strokes from stroke-mimics. Methods. We present here a retrospective analysis of 93 patients over a one-year period (2009 to 2010), who were evaluated for a concern of in-hospital strokes...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27974991/increased-blood-pressure-variability-is-associated-with-worse-neurologic-outcome-in-acute-anterior-circulation-ischemic-stroke
#20
Adam de Havenon, Alicia Bennett, Gregory J Stoddard, Gordon Smith, Haimei Wang, Jana Wold, Lee Chung, David L Tirschwell, Jennifer J Majersik
Background. Although research suggests that blood pressure variability (BPV) is detrimental in the weeks to months after acute ischemic stroke, it has not been adequately studied in the acute setting. Methods. We reviewed acute ischemic stroke patients from 2007 to 2014 with anterior circulation stroke. Mean blood pressure and three BPV indices (standard deviation, coefficient of variation, and successive variation) for the intervals 0-24, 0-72, and 0-120 hours after admission were correlated with follow-up modified Rankin Scale (mRS) in ordinal logistic regression models...
2016: Stroke Research and Treatment
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