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Stroke Research and Treatment

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https://www.readbyqxmd.com/read/27882262/knowledge-of-stroke-risk-factors-among-stroke-survivors-in-nigeria
#1
Grace Vincent-Onabajo, Taritei Moses
Background. Knowledge of stroke risk factors is expected to reduce the incidence of stroke-whether first-ever or recurrent. This study examined knowledge of stroke risk factors and its determinants among stroke survivors. Methods. A cross-sectional survey of consenting stroke survivors at two physiotherapy facilities in Nigeria was carried out. Sociodemographic and clinical data were obtained and knowledge of stroke risk factors (defined as the ability to mention at least one correct risk factor) was assessed using open-ended questionnaire...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27818831/safety-and-efficacy-of-acute-clopidogrel-load-in-patients-with-moderate-and-severe-ischemic-strokes
#2
Amir Shaban, Dominique J Monlezun, Natalia Rincon, Jonathan Tiu, Melisa Valmoria, Sheryl Martin-Schild
Objective. To study the safety and efficacy of a clopidogrel loading dose in patients with moderate and severe acute ischemic strokes. Background. The safety of clopidogrel loading has been extensively investigated in patients with minor strokes and transient ischemic attacks. Methods. Acute ischemic stroke patients presenting consecutively to our center from 07/01/08 to 07/31/13 were screened. Clopidogrel loading was defined as at least 300 mg dose (with or without aspirin) given within 6 hours of admission...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27752389/occupational-therapy-and-physiotherapy-in-acute-stroke-do-rural-patients-receive-less-therapy
#3
Josie Merchant, Gemma Kitsos, Samantha Ashby, Alex Kitsos, Isobel J Hubbard
Objective. To assess whether acute stroke patients in rural hospitals receive less occupational therapy and physiotherapy than those in metropolitan hospitals. Design. Retrospective case-control study of health data in patients ≤10 days after stroke. Setting. Occupational therapy and physiotherapy services in four rural hospitals and one metropolitan hospital. Participants. Acute stroke patients admitted in one health district. Main Outcome Measures. Frequency and duration of face-to-face and indirect therapy sessions...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27688924/ischemic-strokes-observations-from-a-hospital-based-stroke-registry-in-bangladesh
#4
Nirmalendu Bikash Bhowmik, Aamir Abbas, Mohammad Saifuddin, Md Rashedul Islam, Rumana Habib, Aminur Rahman, Md Amirul Haque, Zahid Hassan, Mohammad Wasay
Background. Stroke is an important morbidity for low and middle income countries like Bangladesh. We established the first stroke registry in Bangladesh. Methods. Data was collected from stroke patients who were admitted in Department of Neurology of BIRDEM with first ever stroke, aged between 30 and 90 years. Patients with intracerebral hemorrhage, subarachnoid and subdural hemorrhage, and posttrauma features were excluded. Results. Data was gathered from 679 stroke patients. Mean age was 60.6 years. Almost 68% of patients were male...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27668120/systematic-review-of-hospital-readmissions-in-stroke-patients
#5
REVIEW
Ahsan Rao, Emily Barrow, Sabine Vuik, Ara Darzi, Paul Aylin
Background. Previous evidence on factors and causes of readmissions associated with high-impact users of stroke is scanty. The aim of the study was to investigate common causes and pattern of short- and long-term readmissions stroke patients by conducting a systematic review of studies using hospital administrative data. Common risk factors associated with the change of readmission rate were also examined. Methods. The literature search was conducted from 15 February to 15 March 2016 using various databases, such as Medline, Embase, and Web of Science...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27493828/the-effects-of-power-training-in-young-and-older-adults-after-stroke
#6
Jennifer L Hunnicutt, Stacey E Aaron, Aaron E Embry, Brian Cence, Patrick Morgan, Mark G Bowden, Chris M Gregory
Background. Approximately 35,000 strokes occur annually in adults below the age of 40, and there is disappointingly little data describing their responses to rehabilitation. The purpose of this analysis was to determine the effects of Poststroke Optimization of Walking using Explosive Resistance (POWER) training in young (<40 years) and older (>60 years) adults and to describe relationships between training-induced improvements in muscular and locomotor function. Methods. Data was analyzed from 16 individuals with chronic stroke who participated in 24 sessions of POWER training...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27418997/conductive-education-as-a-method-of-stroke-rehabilitation-a-single-blinded-randomised-controlled-feasibility-study
#7
Judith Bek, Melanie R Brown, Jagjeet Jutley-Neilson, Nicholas C C Russell, Pia A J Huber, Catherine M Sackley
Background. Conductive Education for stroke survivors has shown promise but randomised evidence is unavailable. This study assessed the feasibility of a definitive randomised controlled trial to evaluate efficacy. Methods. Adult stroke survivors were recruited through local community notices. Those completing the baseline assessment were randomised using an online program and group allocation was independent. Intervention group participants received 10 weekly 1.5-hour sessions of Conductive Education at the National Institute of Conductive Education in Birmingham, UK...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27413577/influence-of-medication-on-fatigue-six-months-after-stroke
#8
Amélie Ponchel, Julien Labreuche, Stéphanie Bombois, Christine Delmaire, Régis Bordet, Hilde Hénon
Poststroke fatigue (PSF) is frequent and affects patients' quality of life. Medication use was hypothesized as being responsible for PSF. Our objective was to evaluate potential relationships between 6-month PSF and medication use at discharge and 6 months after an ischemic stroke. This study is part of STROKDEM, an ongoing longitudinal cohort study, whose main aim is to determine predictors of poststroke dementia. Patients were included within 72 hours after an ischemic stroke and followed up with standardized evaluations...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27313948/promoting-optimal-physical-exercise-for-life-an-exercise-and-self-management-program-to-encourage-participation-in-physical-activity-after-discharge-from-stroke-rehabilitation-a-feasibility-study
#9
Avril Mansfield, Svetlana Knorr, Vivien Poon, Elizabeth L Inness, Laura Middleton, Louis Biasin, Karen Brunton, Jo-Anne Howe, Dina Brooks
People with stroke do not achieve adequate levels of physical exercise following discharge from rehabilitation. We developed a group exercise and self-management program (PROPEL), delivered during stroke rehabilitation, to promote uptake of physical activity after discharge. This study aimed to establish the feasibility of a larger study to evaluate the effect of this program on participation in self-directed physical activity. Participants with subacute stroke were recruited at discharge from one of three rehabilitation hospitals; one hospital offered the PROPEL program whereas the other two did not (comparison group; COMP)...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27247825/the-r18-polyarginine-peptide-is-more-effective-than-the-tat-nr2b9c-na-1-peptide-when-administered-60-minutes-after-permanent-middle-cerebral-artery-occlusion-in-the-rat
#10
D Milani, N W Knuckey, R S Anderton, J L Cross, B P Meloni
We examined the dose responsiveness of polyarginine R18 (100, 300, and 1000 nmol/kg) when administered 60 minutes after permanent middle cerebral artery occlusion (MCAO). The TAT-NR2B9c peptide, which is known to be neuroprotective in rodent and nonhuman primate stroke models, served as a positive control. At 24 hours after MCAO, there was reduced total infarct volume in R18 treated animals at all doses, but this reduction only reached statistical significance at doses of 100 and 1000 nmol/kg. The TAT-NR2B9c peptide reduced infarct volume at doses of 300 and 1000 nmol/kg, but not to a statistically significant extent, while the 100 nmol/kg dose was ineffective...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27190674/effect-of-treatment-delay-stroke-type-and-thrombolysis-on-the-effect-of-glyceryl-trinitrate-a-nitric-oxide-donor-on-outcome-after-acute-stroke-a-systematic-review-and-meta-analysis-of-individual-patient-from-randomised-trials
#11
Philip M Bath, Lisa Woodhouse, Kailash Krishnan, Craig Anderson, Eivind Berge, Gary A Ford, Thompson G Robinson, Jeffrey L Saver, Nikola Sprigg, Joanna M Wardlaw, Blood Pressure In Acute Stroke Collaboration Basc
Background. Nitric oxide (NO) donors are a candidate treatment for acute stroke and two trials have suggested that they might improve outcome if administered within 4-6 hours of stroke onset. We assessed the safety and efficacy of NO donors using individual patient data (IPD) from completed trials. Methods. Randomised controlled trials of NO donors in patients with acute or subacute stroke were identified and IPD sought from the trialists. The effect of NO donor versus control on functional outcome was assessed using the modified Rankin scale (mRS) and death, by time to randomisation...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/27088036/analysis-of-the-modified-rankin-scale-in-randomised-controlled-trials-of-acute-ischaemic-stroke-a-systematic-review
#12
Aimie Nunn, Philip M Bath, Laura J Gray
Background. Historically, most acute stroke clinical trials were neutral statistically, with trials typically dichotomising ordinal scales, such as the modified Rankin Scale. Studies published before 2007 have shown that preserving the ordinal nature of these scales increased statistical power. A systematic review of trials published since 2007 was conducted to reevaluate statistical methods used and to assess whether practice has changed. Methods. A search of electronic databases identified RCTs published between January 2007 and July 2014 in acute ischaemic stroke using an ordinal dependency scale as the primary outcome...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/26949561/the-effect-of-electromagnetic-field-treatment-on-recovery-from-ischemic-stroke-in-a-rat-stroke-model-clinical-imaging-and-pathological-findings
#13
Y Segal, L Segal, T Blumenfeld-Katzir, E Sasson, V Poliansky, E Loeb, A Levy, A Alter, N Bregman
Stroke is a leading cause of death and disability. Effects of stroke include significant deficits in sensory-motor skills and cognitive abilities. At present, there are limited effective interventions for postacute stroke patients. In this preliminary research we studied a new noninvasive, very low intensity, low frequency, electromagnetic field treatment (VLIFE), targeting a neural network, on an in vivo stroke rat model. Eighteen rats were divided into three groups: sham (M1) and two treatment groups which were exposed to VLIFE treatment for 4 weeks, one using theta waves (M2) and another using beta waves (M3); all groups were followed up for an additional month...
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/26949560/retracted-results-of-surgical-and-nonsurgical-treatment-of-aneurysms-in-a-developing-country
#14
Stroke Research And Treatment
[This retracts the article DOI: 10.4061/2011/560831.].
2016: Stroke Research and Treatment
https://www.readbyqxmd.com/read/26689491/pharyngeal-electrical-stimulation-for-treatment-of-poststroke-dysphagia-individual-patient-data-meta-analysis-of-randomised-controlled-trials
#15
REVIEW
Polly Scutt, Han S Lee, Shaheen Hamdy, Philip M Bath
Background. Dysphagia after stroke is common, associated independently with poor outcome, and has limited treatment options. Pharyngeal electrical stimulation (PES) is a novel treatment being evaluated for treatment of poststroke dysphagia. Methods. We searched electronically for randomised controlled trials of PES in dysphagic patients within 3 months of stroke. Individual patient data were analysed using regression, adjusted for trial, age, severity, and baseline score. The coprimary outcomes were radiological aspiration (penetration aspiration score, PAS) and clinical dysphagia (dysphagia severity rating scale, DSRS) at 2 weeks; secondary outcomes included functional outcome, death, and length of stay in hospital...
2015: Stroke Research and Treatment
https://www.readbyqxmd.com/read/26664827/improvement-in-paretic-arm-reach-to-grasp-following-low-frequency-repetitive-transcranial-magnetic-stimulation-depends-on-object-size-a-pilot-study
#16
Jarugool Tretriluxana, Shailesh Kantak, Suradej Tretriluxana, Allan D Wu, Beth E Fisher
Introduction. Low frequency repetitive transcranial magnetic stimulation (LF-rTMS) delivered to the nonlesioned hemisphere has been shown to improve limited function of the paretic upper extremity (UE) following stroke. The outcome measures have largely included clinical assessments with little investigation on changes in kinematics and coordination. To date, there is no study investigating how the effects of LF-rTMS are modulated by the sizes of an object to be grasped. Objective. To investigate the effect of LF-rTMS on kinematics and coordination of the paretic hand reach-to-grasp (RTG) for two object sizes in chronic stroke...
2015: Stroke Research and Treatment
https://www.readbyqxmd.com/read/26543664/the-effect-of-telemedicine-on-access-to-acute-stroke-care-in-texas-the-story-of-age-inequalities
#17
Karen C Albright, Amelia K Boehme, Michael T Mullen, Tzu-Ching Wu, Charles C Branas, James C Grotta, Sean I Savitz, Catherine Wolff, Bisakha Sen, Brendan G Carr
Background. Ischemic stroke is a time sensitive disease with the effectiveness of treatment decreasing over time. Treatment is more likely to occur at Primary Stroke Centers (PSC); thus rapid access to acute stroke care through stand-alone PSCs or telemedicine (TM) is vital for all Americans. The objective of this study is to determine if disparities exist in access to PSCs or the extended access to acute stroke care provided by TM. Methods. Data from the US Census Bureau and the 2010 Neilson Claritas Demographic Estimation Program, American Hospital Association annual survey, and The Joint Commission list of PSCs and survey response data for all hospitals in the state of Texas were used...
2015: Stroke Research and Treatment
https://www.readbyqxmd.com/read/26167332/copeptin-limited-usefulness-in-early-stroke-differentiation
#18
Johannes von Recum, Julia Searle, Anna Slagman, Jörn Ole Vollert, Matthias Endres, Martin Möckel, Martin Ebinger
Background. Stroke can be a challenging diagnosis in an emergency-setting. We sought to determine whether copeptin may be a useful biomarker to differentiate between ischemic stroke (IS), transient ischemic attack (TIA), and stroke-mimics. Methods. In patients with suspected stroke arriving within 4.5 hours of symptom-onset, copeptin-levels were measured in initial blood-samples. The final diagnosis was adjudicated by vascular neurologists blinded to copeptin-values. Results. Of all 36 patients with available copeptin-values (median age 71 years, IQR: 54-76; 44% female), 20 patients (56%) were diagnosed with IS, no patient was diagnosed with hemorrhagic stroke, nine patients (25%) were diagnosed with TIA, and seven patients (19%) were stroke-mimics...
2015: Stroke Research and Treatment
https://www.readbyqxmd.com/read/26101691/factors-associated-with-poststroke-fatigue-a-systematic-review
#19
REVIEW
Amélie Ponchel, Stéphanie Bombois, Régis Bordet, Hilde Hénon
Background. Poststroke fatigue (PSF) is a frequent, disabling symptom that lacks a consensual definition and a standardized evaluation method. The (multiple) causes of PSF have not been formally characterized. Objective. To identify factors associated with PSF. Method. A systematic review of articles referenced in MEDLINE. Only original studies having measured PSF and potentially associated factors were included. Data was extracted from articles using predefined data fields. Results. Although PSF tends to be more frequent in female patients and older patients, sociodemographic factors do not appear to have a major impact...
2015: Stroke Research and Treatment
https://www.readbyqxmd.com/read/25722917/medical-acute-complications-of-intracerebral-hemorrhage-in-young-adults
#20
Riku-Jaakko Koivunen, Elena Haapaniemi, Jarno Satopää, Mika Niemelä, Turgut Tatlisumak, Jukka Putaala
Background. Frequency and impact of medical complications on short-term mortality in young patients with intracerebral hemorrhage (ICH) have gone unstudied. Methods. We reviewed data of all first-ever nontraumatic ICH patients between 16 and 49 years of age treated in our hospital between January 2000 and March 2010 to identify medical complications suffered. Logistic regression adjusted for known ICH prognosticators was used to identify medical complications associated with mortality. Results. Among the 325 eligible patients (59% males, median age 42 [interquartile range 34-47] years), infections were discovered in 90 (28%), venous thrombotic events in 13 (4%), cardiac complications in 4 (1%), renal failure in 59 (18%), hypoglycemia in 15 (5%), hyperglycemia in 165 (51%), hyponatremia in 146 (45%), hypernatremia in 91 (28%), hypopotassemia in 104 (32%), and hyperpotassemia in 27 (8%)...
2015: Stroke Research and Treatment
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