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Journal of Pathology Informatics

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https://www.readbyqxmd.com/read/28584684/current-state-of-the-regulatory-trajectory-for-whole-slide-imaging-devices-in-the-usa
#1
REVIEW
Esther Abels, Liron Pantanowitz
The regulatory field for digital pathology (DP) has advanced significantly. A major milestone was accomplished when the FDA allowed the first vendor to market their device for primary diagnostic use in the USA and published in the classification order that this device, and substantially equivalent devices of this generic type, should be classified into class II instead of class III as previously proposed. The Digital Pathology Association (DPA) regulatory task force had a major role in the accomplishment of getting the application request for Whole Slide Imaging (WSI) Systems recommended for a de novo...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28584683/training-nuclei-detection-algorithms-with-simple-annotations
#2
Henning Kost, André Homeyer, Jesper Molin, Claes Lundström, Horst Karl Hahn
BACKGROUND: Generating good training datasets is essential for machine learning-based nuclei detection methods. However, creating exhaustive nuclei contour annotations, to derive optimal training data from, is often infeasible. METHODS: We compared different approaches for training nuclei detection methods solely based on nucleus center markers. Such markers contain less accurate information, especially with regard to nuclear boundaries, but can be produced much easier and in greater quantities...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28480122/the-need-for-careful-data-collection-for-pattern-recognition-in-digital-pathology
#3
Raphaël Marée
Effective pattern recognition requires carefully designed ground-truth datasets. In this technical note, we first summarize potential data collection issues in digital pathology and then propose guidelines to build more realistic ground-truth datasets and to control their quality. We hope our comments will foster the effective application of pattern recognition approaches in digital pathology.
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28480121/alchemy-a-web-2-0-real-time-quality-assurance-platform-for-human-immunodeficiency-virus-hepatitis-c-virus-and-bk-virus-quantitation-assays
#4
Emmanuel Agosto-Arroyo, Gina M Coshatt, Thomas S Winokur, Shuko Harada, Seung L Park
BACKGROUND: The molecular diagnostics laboratory faces the challenge of improving test turnaround time (TAT). Low and consistent TATs are of great clinical and regulatory importance, especially for molecular virology tests. Laboratory information systems (LISs) contain all the data elements necessary to do accurate quality assurance (QA) reporting of TAT and other measures, but these reports are in most cases still performed manually: a time-consuming and error-prone task. The aim of this study was to develop a web-based real-time QA platform that would automate QA reporting in the molecular diagnostics laboratory at our institution, and minimize the time expended in preparing these reports...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28480120/compromising-the-security-of-generating-unique-identifiers-from-patient-identification-data-using-security-models
#5
Arran Schlosberg
No abstract text is available yet for this article.
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28480119/evaluation-of-android-smartphones-for-telepathology
#6
Donald Ekong, Fang Liu, G Thomas Brown, Arunima Ghosh, Paul Fontelo
BACKGROUND: In the year 2014, Android smartphones accounted for one-third of mobile connections globally but are predicted to increase to two-thirds by 2020. In developing countries, where teleconsultations can benefit health-care providers most, the ratio is even higher. This study compared the use of two Android phones, an 8 megapixel (MP) and a 16 MP phone, for capturing microscopic images. METHOD: The Android phones were used to capture images and videos of a gastrointestinal biopsy teaching set of referred cases from the Armed Forces Institute of Pathology (AFIP)...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28480118/predictive-nuclear-chromatin-characteristics-of-melanoma-and-dysplastic-nevi
#7
Matthew G Hanna, Chi Liu, Gustavo K Rohde, Rajendra Singh
BACKGROUND: The diagnosis of malignant melanoma (MM) is among the diagnostic challenges pathologists encounter on a routine basis. Melanoma may arise in patients with preexisting dysplastic nevi (DN) and it is still the cause of 1.7% of all cancer-related deaths. Melanomas often have overlapping histological features with DN, especially those with severe dysplasia. Nucleotyping for identifying nuclear textural features can analyze nuclear DNA structure and organization. The aim of this study is to differentiate MM and DN using these methodologies...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28480117/making-pathology-diagnoses-with-glass-or-digital-slides-which-modality-is-inferior
#8
COMMENT
Jonhan Ho, Liron Pantanowitz
No abstract text is available yet for this article.
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28400996/open-source-software-for-demand-forecasting-of-clinical-laboratory-test-volumes-using-time-series-analysis
#9
Emad A Mohammed, Christopher Naugler
BACKGROUND: Demand forecasting is the area of predictive analytics devoted to predicting future volumes of services or consumables. Fair understanding and estimation of how demand will vary facilitates the optimal utilization of resources. In a medical laboratory, accurate forecasting of future demand, that is, test volumes, can increase efficiency and facilitate long-term laboratory planning. Importantly, in an era of utilization management initiatives, accurately predicted volumes compared to the realized test volumes can form a precise way to evaluate utilization management initiatives...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28400995/whatsapp-for-teaching-pathology-postgraduates-a-pilot-study
#10
Aditi Goyal, Nadeem Tanveer, Pooja Sharma
INTRODUCTION: Postgraduate students spend a sizeable proportion of their time on social media platforms such as WhatsApp and Facebook. This change in our social interaction needs to be accommodated in our teaching methods. To engage them and arouse their curiosity, WhatsApp is an ideal platform. Digital photography by cell phone cameras has made it possible to share cases and discuss them with students round the clock. OBJECTIVE: The primary aim of the study was to develop sharing and discussion of images using WhatsApp...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28400994/pathological-diagnosis-of-gastric-cancers-with-a-novel-computerized-analysis-system
#11
Kosuke Oikawa, Akira Saito, Tomoharu Kiyuna, Hans Peter Graf, Eric Cosatto, Masahiko Kuroda
BACKGROUND: Recent studies of molecular biology have provided great advances for diagnostic molecular pathology. Automated diagnostic systems with computerized scanning for sampled cells in fluids or smears are now widely utilized. Automated analysis of tissue sections is, however, very difficult because they exhibit a complex mixture of overlapping malignant tumor cells, benign host-derived cells, and extracellular materials. Thus, traditional histological diagnosis is still the most powerful method for diagnosis of diseases...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28400993/criteria-to-screen-molecular-tests-for-the-diagnosis-of-herpes-simplex-virus-in-the-central-nervous-system-have-no-propensity-to-harm
#12
Ronald George Hauser, Cynthia A Brandt, Richard A Martinello
OBJECTIVES: Investigators have ruled out herpes simplex virus (HSV) infection without the detection of herpes simplex deoxyribonucleic acid in cerebrospinal fluid (CSF) (i.e., HSV polymerase chain reaction [PCR]) by laboratory (normal CSF white blood cell count and protein) and clinical criteria (age ≥2 years, no history of human immunodeficiency virus or solid-organ transplant). Compared to HSV PCR of all samples, the algorithm saves money in test costs and may decrease exposure to acyclovir by illustrating the low probability that the patient has HSV...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28400992/implementation-of-a-software-application-for-presurgical-case-history-review-of-frozen-section-pathology-cases
#13
Andrew P Norgan, Mathew L Okeson, Justin E Juskewitch, Kabeer K Shah, William R Sukov
BACKGROUND: The frozen section pathology practice at Mayo Clinic in Rochester performs ~20,000 intraoperative consultations a year (~70-80/weekday). To prepare for intraoperative consultations, surgical pathology fellows and residents review the case history, previous pathology, and relevant imaging the day before surgery. Before the work described herein, review of pending surgical pathology cases was a paper-based process requiring handwritten transcription from the electronic health record, a laborious and potentially error prone process...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28400991/computer-science-biology-and-biomedical-informatics-academy-outcomes-from-5-years-of-immersing-high-school-students-into-informatics-research
#14
EDITORIAL
Andrew J King, Arielle M Fisher, Michael J Becich, David N Boone
The University of Pittsburgh's Department of Biomedical Informatics and Division of Pathology Informatics created a Science, Technology, Engineering, and Mathematics (STEM) pipeline in 2011 dedicated to providing cutting-edge informatics research and career preparatory experiences to a diverse group of highly motivated high-school students. In this third editorial installment describing the program, we provide a brief overview of the pipeline, report on achievements of the past scholars, and present results from self-reported assessments by the 2015 cohort of scholars...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28400990/classifications-of-multispectral-colorectal-cancer-tissues-using-convolution-neural-network
#15
Hawraa Haj-Hassan, Ahmad Chaddad, Youssef Harkouss, Christian Desrosiers, Matthew Toews, Camel Tanougast
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer among men and women. Its diagnosis in early stages, typically done through the analysis of colon biopsy images, can greatly improve the chances of a successful treatment. This paper proposes to use convolution neural networks (CNNs) to predict three tissue types related to the progression of CRC: benign hyperplasia (BH), intraepithelial neoplasia (IN), and carcinoma (Ca). METHODS: Multispectral biopsy images of thirty CRC patients were retrospectively analyzed...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28382227/performance-of-a-web-based-method-for-generating-synoptic-reports
#16
Megan A Renshaw, Scott A Renshaw, Mercy Mena-Allauca, Patricia P Carrion, Xiaorong Mei, Arniris Narciandi, Edwin W Gould, Andrew A Renshaw
CONTEXT: The College of American Pathologists (CAP) requires synoptic reporting of all tumor excisions. OBJECTIVE: To compare the performance of different methods of generating synoptic reports. METHODS: Completeness, amendment rates, rate of timely ordering of ancillary studies (KRAS in T4/N1 colon carcinoma), and structured data file extraction were compared for four different synoptic report generating methods. RESULTS: Use of the printed tumor protocols directly from the CAP website had the lowest completeness (84%) and highest amendment (1...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28382226/a-randomized-study-comparing-digital-imaging-to-traditional-glass-slide-microscopy-for-breast-biopsy-and-cancer-diagnosis
#17
Joann G Elmore, Gary M Longton, Margaret S Pepe, Patricia A Carney, Heidi D Nelson, Kimberly H Allison, Berta M Geller, Tracy Onega, Anna N A Tosteson, Ezgi Mercan, Linda G Shapiro, Tad T Brunyé, Thomas R Morgan, Donald L Weaver
BACKGROUND: Digital whole slide imaging may be useful for obtaining second opinions and is used in many countries. However, the U.S. Food and Drug Administration requires verification studies. METHODS: Pathologists were randomized to interpret one of four sets of breast biopsy cases during two phases, separated by ≥9 months, using glass slides or digital format (sixty cases per set, one slide per case, n = 240 cases). Accuracy was assessed by comparing interpretations to a consensus reference standard...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28382225/turning-microscopy-in-the-medical-curriculum-digital-experiences-from-the-faculty-of-health-and-medical-sciences-at-university-of-copenhagen
#18
Ben Vainer, Niels Werner Mortensen, Steen Seier Poulsen, Allan Have Sørensen, Jørgen Olsen, Hans Henrik Saxild, Flemming Fryd Johansen
Familiarity with the structure and composition of normal tissue and an understanding of the changes that occur during disease is pivotal to the study of the human body. For decades, microscope slides have been central to teaching pathology in medical courses and related subjects at the University of Copenhagen. Students had to learn how to use a microscope and envisage three-dimensional processes that occur in the body from two-dimensional glass slides. Here, we describe how a PathXL virtual microscopy system for teaching pathology and histology at the Faculty has recently been implemented, from an administrative, an economic, and a teaching perspective...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28382224/recutclub-com-an-open-source-whole-slide-image-based-pathology-education-system
#19
Paul A Christensen, Nathan E Lee, Michael J Thrall, Suzanne Z Powell, Patricia Chevez-Barrios, S Wesley Long
BACKGROUND: Our institution's pathology unknown conferences provide educational cases for our residents. However, the cases have not been previously available digitally, have not been collated for postconference review, and were not accessible to a wider audience. Our objective was to create an inexpensive whole slide image (WSI) education suite to address these limitations and improve the education of pathology trainees. MATERIALS AND METHODS: We surveyed residents regarding their preference between four unique WSI systems...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28382223/identification-of-histological-correlates-of-overall-survival-in-lower-grade-gliomas-using-a-bag-of-words-paradigm-a-preliminary-analysis-based-on-hematoxylin-eosin-stained-slides-from-the-lower-grade-glioma-cohort-of-the-cancer-genome-atlas
#20
Reid Trenton Powell, Adriana Olar, Shivali Narang, Ganesh Rao, Erik Sulman, Gregory N Fuller, Arvind Rao
BACKGROUND: Glioma, the most common primary brain neoplasm, describes a heterogeneous tumor of multiple histologic subtypes and cellular origins. At clinical presentation, gliomas are graded according to the World Health Organization guidelines (WHO), which reflect the malignant characteristics of the tumor based on histopathological and molecular features. Lower grade diffuse gliomas (LGGs) (WHO Grade II-III) have fewer malignant characteristics than high-grade gliomas (WHO Grade IV), and a better clinical prognosis, however, accurate discrimination of overall survival (OS) remains a challenge...
2017: Journal of Pathology Informatics
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