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Journal of Pathology Informatics

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https://www.readbyqxmd.com/read/30294502/innovation-in-transplantation-the-digital-era
#1
Albino Eccher, Matteo Brunelli, Liron Pantanowitz, Anil Parwani, Ilaria Girolami, Aldo Scarpa
The international symposium entitled "Innovation in Transplantation: The Digital Era" took place on June 7 and 8, 2018 in Verona, Italy. This meeting was borne out of the productive collaboration between the Universities and Hospital Trusts of Verona and Padua in Italy, in the context of a vast regional project called Research and innovation project within the Health Technology Assessment. The project aimed to create an innovative digital platform for teleconsultation and delivering diagnostic second opinions in the field of organ transplantation within the Veneto region...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/30294501/diagnostic-performance-of-deep-learning-algorithms-applied-to-three-common-diagnoses-in-dermatopathology
#2
Thomas George Olsen, B Hunter Jackson, Theresa Ann Feeser, Michael N Kent, John C Moad, Smita Krishnamurthy, Denise D Lunsford, Rajath E Soans
Background: Artificial intelligence is advancing at an accelerated pace into clinical applications, providing opportunities for increased efficiency, improved accuracy, and cost savings through computer-aided diagnostics. Dermatopathology, with emphasis on pattern recognition, offers a unique opportunity for testing deep learning algorithms. Aims: This study aims to determine the accuracy of deep learning algorithms to diagnose three common dermatopathology diagnoses...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/30294500/using-heatmaps-to-identify-opportunities-for-optimization-of-test-utilization-and-care-delivery
#3
Yonah C Ziemba, Liya Lomsadze, Yehuda Jacobs, Tylis Y Chang, Nina Haghi
Background: When a provider orders a test in a pattern that is substantially different than their peers, it may indicate confusion in the test name or inappropriate use of the test, which can be elucidated by initiating dialog between clinicians and the laboratory. However, the analysis of ordering patterns can be challenging. We propose a utilization index (UI) as a means to quantify utilization patterns for individual providers and demonstrate the use of heatmaps to identify opportunities for improvement...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/30237909/the-human-interface-of-biomedical-informatics
#4
REVIEW
Edward C Klatt
Biomedical informatics is the science of information, where information is defined as data with meaning. This definition identifies a fundamental challenge for informaticians: connecting with the healthcare team by enabling the acquisition, retrieval, and processing of information within the cognitive capabilities of the human brain. Informaticians can become aware of the constraints involved with cognitive processing and with workplace factors that impact how information is acquired and used to facilitate an improved user interface providing information to healthcare teams...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/30197818/conventional-microscopical-versus-digital-whole-slide-imaging-based-diagnosis-of-thin-layer-cervical-specimens-a-validation-study
#5
Odille Bongaerts, Carla Clevers, Marij Debets, Daniëlle Paffen, Lisanne Senden, Kim Rijks, Linda Ruiten, Daisy Sie-Go, Paul J van Diest, Marius Nap
Background: Whole-slide imaging (WSI) has been implemented in many areas of pathology, but primary diagnostics of cytological specimens are lagging behind. One of the objectives of viewing scanned whole-slide images from histological or cytological specimens is remote exchange of knowledge and expertise of professionals to increase diagnostic accuracy. We compared the scoring results of our team obtained in double readings of two different data sets: conventional light microscopy (CLM) versus CLM and CLM versus WSI...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/30167343/virtual-autopsy-as-a-screening-test-before-traditional-autopsy-the-verona-experience-on-25-cases
#6
Vito Cirielli, Luca Cima, Federica Bortolotti, Murali Narayanasamy, Maria Pia Scarpelli, Olivia Danzi, Matteo Brunelli, Albino Eccher, Francesca Vanzo, Maria Chiara Ambrosetti, Ghassan El-Dalati, Peter Vanezis, Domenico De Leo, Franco Tagliaro
Background: Interest has grown into the use of multidetector computed tomography (CT) and magnetic resonance imaging as an adjunct or alternative to the invasive autopsy. We sought to investigate these possibilities in postmortem CT scan using an innovative virtual autopsy approach. Methods: Twenty-five postmortem cases were scanned with the Philips Brilliance CT-64 and then underwent traditional autopsy. The images were interpreted by two blinded forensic pathologists assisted by a radiologist with the INFOPSY® Digital Autopsy Software System which provides three-dimensional images in Digital Imaging and Communications in Medicine format...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/30167342/will-digital-pathology-be-as-disruptive-as-genomics
#7
Steven N Hart
Digital pathology is the science of performing traditional pathological assessment in a digital environment. A digital transition is long overdue since histochemical analysis such as hematoxylin and eosin staining has remained unchanged in over 100 years. Importantly, the digitization of whole slide images further lends itself to advances in computational pathology and artificial intelligence to transform qualitative assessment into quantitative assessment. The impact of this transition from a computational infrastructure perspective is reminiscent of a similar transition in the field of genomics...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/30167341/a-new-software-platform-to-improve-multidisciplinary-tumor-board-workflows-and-user-satisfaction-a-pilot-study
#8
Elizabeth A Krupinski, Merce Comas, Leia Garrote Gallego
Background: Workflow and preparation for holding multidisciplinary cancer case reviews (i.e., Tumor Boards) is time-consuming and cumbersome. Use of a software platform might improve this process. This pilot study assessed the impact of a new software platform on tumor board preparation workflow and user satisfaction compared to current methods. Materials and Methods: Using current methods and the NAVIFY Tumor Board Solution, this study assessed the number of tasks and time to prepare tumor board cases...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/30034922/interfacing-complex-laboratory-instruments-during-a-change-to-epic-beaker
#9
Gregory David Scott, Cary Schrandt, Chandler C Ho, Michael C Chung, Daniel Zhou, Run Zhang Shi
Background: Implementing a laboratory-developed test sometimes requires incorporating an unconventional device into the laboratory information system (LIS) and customizing an interface to reduce transcription error and improve turnaround time. Such a custom interface is a necessity for complicated high-volume tests such as 25-OH Vitamin D by liquid chromatography-tandem mass spectrometry (LC-MS/MS) when there is no vendor-or LIS-supplied interface available. Here, we describe our work and experience interfacing a API 5000 LC-MS/MS instrument with our newly implemented LIS, Epic Beaker, using a combination of in-house scripting software and a middleware vendor, Data Innovations...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/30034921/next-generation-sequencing-bioinformatics-guidance-between-the-sequencing-and-sign-out
#10
Jeffrey Szymanski, Eric Duncavage, John Pfeifer
No abstract text is available yet for this article.
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/30034920/commentary-what-can-augmented-reality-do-for-you
#11
Emilio Madrigal
No abstract text is available yet for this article.
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/30034919/machine-learning-provides-an-accurate-classification-of-diffuse-large-b-cell-lymphoma-from-immunohistochemical-data
#12
Carlos Bruno Tavares Da Costa
Background: The classification of diffuse large B-cell lymphomas into Germinal Center (GCB) and non-GC subtypes defines disease subgroups which are different both in terms of gene expression and prognosis. Given their clinical significance, several classification algorithms have been designed, some by making use of widely availability immunohistochemical techniques. Despite their high concordance with gene expression profiles (GEP) and prognostic value, these algorithms were based on technical and biological assumptions that could be improved in terms of performance for classification...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29910969/optimized-jpeg-2000-compression-for-efficient-storage-of-histopathological-whole-slide-images
#13
Henrik Helin, Teemu Tolonen, Onni Ylinen, Petteri Tolonen, Juha Näpänkangas, Jorma Isola
Background: Whole slide images (WSIs, digitized histopathology glass slides) are large data files whose long-term storage remains a significant cost for pathology departments. Currently used WSI formats are based on lossy image compression alogrithms, either using JPEG or its more efficient successor JPEG 2000. While the advantages of the JPEG 2000 algorithm (JP2) are commonly recognized, its compression parameters have not been fully optimized for pathology WSIs. Methods: We defined an optimized parametrization for JPEG 2000 image compression, designated JP2-WSI, to be used specifically with histopathological WSIs...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29910968/utilization-of-open-source-technology-to-create-cost-effective-microscope-camera-systems-for-teaching
#14
Anil Reddy Konduru, Balasaheb R Yelikar, K V Sathyashree, Ankur Kumar
Background: Open source technologies and mobile innovations have radically changed the way people interact with technology. These innovations and advancements have been used across various disciplines and already have a significant impact. Microscopy, with focus on visually appealing contrasting colors for better appreciation of morphology, forms the core of the disciplines such as Pathology, microbiology, and anatomy. Here, learning happens with the aid of multi-head microscopes and digital camera systems for teaching larger groups and in organizing interactive sessions for students or faculty of other departments...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29862128/can-text-search-methods-of-pathology-reports-accurately-identify-patients-with-rectal-cancer-in-large-administrative-databases
#15
Reilly P Musselman, Deanna Rothwell, Rebecca C Auer, Husein Moloo, Robin P Boushey, Carl van Walraven
Background: The aim of this study is to derive and to validate a cohort of rectal cancer surgical patients within administrative datasets using text-search analysis of pathology reports. Materials and Methods: A text-search algorithm was developed and validated on pathology reports from 694 known rectal cancers, 1000 known colon cancers, and 1000 noncolorectal specimens. The algorithm was applied to all pathology reports available within the Ottawa Hospital Data Warehouse from 1996 to 2010...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29862127/convolutional-deep-belief-network-with-feature-encoding-for-classification-of-neuroblastoma-histological-images
#16
Soheila Gheisari, Daniel R Catchpoole, Amanda Charlton, Paul J Kennedy
Background: Neuroblastoma is the most common extracranial solid tumor in children younger than 5 years old. Optimal management of neuroblastic tumors depends on many factors including histopathological classification. The gold standard for classification of neuroblastoma histological images is visual microscopic assessment. In this study, we propose and evaluate a deep learning approach to classify high-resolution digital images of neuroblastoma histology into five different classes determined by the Shimada classification...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29770255/a-method-for-the-interpretation-of-flow-cytometry-data-using-genetic-algorithms
#17
Cesar Angeletti
Background: Flow cytometry analysis is the method of choice for the differential diagnosis of hematologic disorders. It is typically performed by a trained hematopathologist through visual examination of bidimensional plots, making the analysis time-consuming and sometimes too subjective. Here, a pilot study applying genetic algorithms to flow cytometry data from normal and acute myeloid leukemia subjects is described. Subjects and Methods: Initially, Flow Cytometry Standard files from 316 normal and 43 acute myeloid leukemia subjects were transformed into multidimensional FITS image metafiles...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29770254/patient-portal-access-to-diagnostic-test-results
#18
Beuy Joob, Viroj Wiwanitkit
No abstract text is available yet for this article.
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29721362/career-paths-of-pathology-informatics-fellowship-alumni
#19
Joseph W Rudolf, Christopher A Garcia, Matthew G Hanna, Christopher L Williams, Ulysses G Balis, Liron Pantanowitz, J Mark Tuthill, John R Gilbertson
Background: The alumni of today's Pathology Informatics and Clinical Informatics fellowships fill diverse roles in academia, large health systems, and industry. The evolving training tracks and curriculum of Pathology Informatics fellowships have been well documented. However, less attention has been given to the posttraining experiences of graduates from informatics training programs. Here, we examine the career paths of subspecialty fellowship-trained pathology informaticians. Methods: Alumni from four Pathology Informatics fellowship training programs were contacted for their voluntary participation in the study...
2018: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29721361/constant-quest-for-quality-digital-cytopathology
#20
Simone L Van Es, Janelle Greaves, Stephanie Gay, Jennifer Ross, Derek Holzhauser, Tony Badrick
Background: Special consideration should be given when creating and selecting cytopathology specimens for digitization to maximize quality. Advances in scanning and viewing technology can also improve whole-slide imaging (WSI) output quality. Methods: Accumulated laboratory experience with digitization of glass cytopathology slides was collected. Results: This paper describes characteristics of a cytopathology glass slide that can reduce quality on resulting WSI...
2018: Journal of Pathology Informatics
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