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Frontline Gastroenterology

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https://www.readbyqxmd.com/read/30245799/first-uk-data-for-ct-angiography-in-persisting-upper-gi-bleeding
#1
Suneil A Raju, Peter D Mooney, Karuna Kodali, Charmaine Toh, Daniel Kusumawidjaja, Naomi Hersey, Hugo Penny, Matthew Kurien, David S Sanders
No abstract text is available yet for this article.
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245798/sheffield-clinical-research-fellowship-programme-a-transferable-model-for-uk-gastroenterology
#2
Matthew Kurien, Andrew Hopper, Alan J Lobo, Mark E McAlindon, Reena Sidhu, Dermot C Gleeson, John M Hebden, Kumar Basu, Simon Panter, Melanie Lockett, David S Sanders
Out of programme (OOP) opportunities are to be encouraged. This article gives an insightful view of the Sheffield Clinical Research Fellowship Programme. Unique trainee feedback is provided. The take home message is clear - trainees should grab OOP experiences with both hands! For consultants the logistics described are potentially transferrable to their own regions.
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245797/thoracic-and-abdominal-pain-in-a-28-year-old-woman-with-a-failing-kidney-transplant
#3
Kirill Pavlov, Parweez Koehestanie, Jaap J Beutler, Tessa E H Römkens, Ellen K Hoogeveen, Loes H C Nissen
This case report describes a young, immunocompromised patient who presented with thoracic pain. After an extensive workup, she was diagnosed with a varicella zoster virus infection with involvement of the gastric mucosa, pancreas and lungs for which she was treated with acyclovir. Although the viral load decreased significantly, the patient had persistent postherpetic neuralgia and nausea.
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245796/day-case-treat-and-transfer-ercp-service-under-general-anaesthesia
#4
Yasser El-Sherif, John Hunt, Abid Suddle, Brian Prater, David Reffitt, John Devlin, Phillip Harrison, Deepak Joshi
Objective: General anaesthesia (GA) has been increasingly used for advanced endoscopic procedures in particular endoscopic retrograde cholangiopancreatography (ERCP). Given the increasing pressure on many hospitals, the delivery of such service on a regular basis may not always be possible. We established a new day case 'GA ERCP' service. We describe our experience in evaluating the safety and overall feasibility of this new service. Design: Prospective database has been interrogated for the period from March 2015 to December 2016...
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245795/positioning-cholangioscopy-in-bile-duct-stone-management-mind-the-technology-gap
#5
EDITORIAL
Vincent Zimmer, Frank Lammert
No abstract text is available yet for this article.
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245794/standardising-assessment-and-documentation-of-pouchoscopy
#6
Valerie Annerijn van der Ploeg, Yasuko Maeda, Omar D Faiz, Ailsa L Hart, Susan K Clark
Background/aims: Variation in quality of reporting on endoscopic procedures is a common clinical problem. Findings are not documented in a standardised manner and there is a tendency towards reporting abnormal findings only. This study aimed to review quality of flexible pouchoscopy reports and to develop a standardised reporting template. Methods: Ileo-anal-pouch experts (n=5) compiled a list of items that should be documented at flexible pouchoscopy. Reports were reviewed retrospectively for their completeness compared with the template...
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245793/optimising-the-performance-and-interpretation-of-small-bowel-capsule-endoscopy
#7
REVIEW
Sabina Beg, Adolfo Parra-Blanco, Krish Ragunath
Small bowel capsule endoscopy has become a commonly used tool in the investigation of gastrointestinal symptoms and is now widely available in clinical practice. In contrast to conventional endoscopy, there is a lack of clear consensus on when competency is achieved or the way in which capsule endoscopy should be performed in order to maintain quality and clinical accuracy. Here we explore the evidence on the key factors that influence the quality of small bowel capsule endoscopy services.
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245792/a-prospective-study-of-faecal-immunochemical-testing-following-polypectomy-in-a-colorectal-cancer-screening-population
#8
David J Gibson, Blathnaid Nolan, Joanna Rea, Maire Buckley, Gareth Horgan, Kieran Sheahan, Glen A Doherty, Diarmuid O'Donoghue, Hugh E Mulcahy, Alan Smith, Garret Cullen
Introduction: 52% of faecal immunohistochemistry test (FIT)-positive clients in the Irish National Colorectal Cancer Screening Programme (BowelScreen) have adenomatous polyps identified at colonoscopy in round 1. Although it is known that advanced adenomas and cancers cause an elevated FIT, it is not known if small (<5 mm) adenomas cause a positive FIT. Aims: Determine if removal of small polyps in an FIT-based colorectal cancer (CRC) screening programme is associated with a negative FIT on follow-up...
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245791/evaluation-of-the-clinical-and-cost-effectiveness-of-the-york-faecal-calprotectin-care-pathway
#9
James Turvill, Daniel Turnock, Hayden Holmes, Alison Jones, Eleanor Mclaughlan, Victoria Hilton, Stacey Marriott
Objective: To evaluate the sensitivity and specificity of the York Faecal Calprotectin Care Pathway (YFCCP) and undertake a health economics analysis. The YFCCP has been introduced in support of the National Institute for Health and Care Excellence (NICE) guidance DG11. It is designed to improve the sensitivity and specificity of faecal calprotectin (FC) in discriminating the irritable bowel syndrome from inflammatory bowel disease in primary care. Design: To prospectively evaluate the clinical outcomes at 6 months of the first 1005 patients entering the YFCCP...
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245790/systematic-review-and-meta-analysis-does-colonic-mural-thickening-on-ct-correlate-with-endoscopic-findings-at-colonoscopy
#10
REVIEW
Subashini Chandrapalan, Faraz Tahir, Peter Kimani, Rakesh Sinha, Ramesh Arasaradnam
Background: Colonic mural thickening (MT) is often reported on standard CT examinations of the abdomen and pelvis. It often presents a dilemma for the clinician on whether any further evaluation is needed, especially in the absence of any set guidelines. Objective: To evaluate the significance of colonic MT and to assess its correlation with colonoscopy. Methods: The search strategy was initially developed in Medline and adapted for use in Embase, Medline, NHS Evidence and TRIP...
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245789/curriculum-review-colorectal-cancer-surveillance-and-management-of-dysplasia-in-ibd
#11
REVIEW
Hajir Ibraheim, Angad Singh Dhillon, Ioannis Koumoutsos, Shraddha Gulati, Bu'Hussain Hayee
The significantly increased risk of colorectal cancer (CRC) in longstanding colonic inflammatory bowel disease (IBD) justifies the need for endoscopic surveillance. Unlike sporadic CRC, IBD-related CRC does not always follow the predictable sequence of low-grade to high-grade dysplasia and finally to invasive carcinoma, probably because the genetic events shared by both diseases occur in different sequences and frequencies. Surveillance is recommended for patients who have had colonic disease for at least 8-10 years either annually, every 3 years or every 5 years with the interval dependant on the presence of additional risk factors...
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245788/oral-direct-acting-antivirals-and-the-incidence-or-recurrence-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#12
Sonal Singh, Amit Nautiyal, Yoon K Loke
Background: The influence of direct-acting antiviral (DAA) therapy for chronic hepatitis C virus on the risk of hepatocellular carcinoma (HCC) is conflicting. Methods: We conducted a systematic review and meta-analysis to determine the incidence or recurrence of HCC associated with oral DAA therapy. We searched PubMed, Scopus, Embase from inception to August 2017 to identify observational studies reporting on HCC among patients treated with DAAs. Two independent reviewers extracted data and assessed the risk of bias...
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245787/examining-the-relationship-between-sepsis-and-oropharyngeal-dysphagia-in-hospitalised-elderly-patients-a-retrospective-cohort-study
#13
Ayodele Sasegbon, Laura O'Shea, Shaheen Hamdy
Introduction: Elderly people are recognised to be at increased risk of oropharyngeal dysphagia (OPD), the causes of which are multifactorial. Our aim was to identify if sepsis is associated with OPD in the elderly during hospitalisation in the absence of known other risk factors for OPD. Methods: A hospital electronic database was searched for elderly patients (≥65 years) referred for assessment for suspected dysphagia between March 2013 and 2014. Exclusion criteria were age <65 years, pre-existing OPD or acute OPD secondary to acute intracranial event, space-occupying lesion or trauma...
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245786/faecal-microbiota-transplantation-as-a-treatment-for-inflammatory-bowel-disease-a-national-survey-of-adult-and-paediatric-gastroenterologists-in-the-uk
#14
James Roger Mcilroy, Niharika Nalagatla, Richard Hansen, Ailsa Hart, Georgina Louise Hold
Background: Interest in the use of faecal microbiota transplantation (FMT) in inflammatory bowel disease (IBD) has increased following outcomes in patients with Clostridioides difficile infection (CDI). While research exploring clinician awareness and attitude towards the use of FMT in CDI has been carried out, data for IBD are currently lacking. Objective: To assess the perceptions of gastroenterologists and current practice relating to FMT as a treatment for IBD in the UK...
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30245785/excellence-is-a-habit-not-an-act
#15
Anton V Emmanuel
No abstract text is available yet for this article.
October 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30047549/golimumab-early-experience-and-medium-term-outcomes-from-two-uk-tertiary-ibd-centres
#16
Mark A Samaan, Polychronis Pavlidis, Jonathan Digby-Bell, Emma L Johnston, Angad Dhillon, Ramesh Paramsothy, Abisoye O Akintimehin, Lucy Medcalf, Guy Chung-Faye, Patrick DuBois, Ioannis Koumoutsos, Nick Powell, Simon H C Anderson, Jeremy Sanderson, Bu' Hussain Hayee, Peter M Irving
Objective: To gain an understanding of the effectiveness of golimumab in a 'real-world' setting. Design: Retrospective cohort study using prospectively maintained clinical records. Setting: Two UK tertiary IBD centres. Patients: Patients with ulcerative colitis (UC) were given golimumab at Guy's & St Thomas and King's College Hospitals between September 2014 and December 2016. Intervention: Golimumab, a subcutaneously administered antitumour necrosis factor agent...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30047548/golimumab-for-ulcerative-colitis-adding-perspective-to-the-pursuit
#17
EDITORIAL
Jimmy K Limdi
No abstract text is available yet for this article.
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046429/associations-between-diagnostic-pathways-and-care-experience-in-colorectal-cancer-evidence-from-patient-reported-data
#18
Theodosia Salika, Gary A Abel, Silvia C Mendonca, Christian von Wagner, Cristina Renzi, Annie Herbert, Sean McPhail, Georgios Lyratzopoulos
Objective: To examine how different pathways to diagnosis of colorectal cancer may be associated with the experience of subsequent care. Design: Patient survey linked to information on diagnostic route.English patients with colorectal cancer (analysis sample n=6837) who responded to a patient survey soon after their hospital treatment. Main outcome measures: Odds Ratios and adjusted proportions of negative evaluation of key aspects of care for colorectal cancer, including the experience of shared decision-making about treatment, specialist nursing and care coordination, by diagnostic route (ie, screening detection, emergency presentation, urgent and elective general practitioner referral)...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046428/challenges-in-screening-for-latent-tuberculosis-in-inflammatory-bowel-disease-prior-to-biologic-treatment-a-uk-cohort-study
#19
Aye Aye Thi, Aula Abbara, Sonia Bouri, Simon M Collin, Paul Wolfson, Leah Owen, Kevin G Buell, Laurence John, Ailsa L Hart
Objective: The aim of this study was to determine the occurrence of latent tuberculosis infections (LTBI) and active TB in a cohort of patients with inflammatory bowel disease (IBD) treated with biologics. We also examined the effects of immunosuppressive drugs on indeterminate interferon-gamma release assays (IGRA) in LTBI screening. Design: Retrospective study of patients treated with biologics between March 2007 and November 2015. Setting: St Mark's Hospital, North West London, UK...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046427/cervical-inlet-patch-new-insights-into-diagnosis-and-endoscopic-therapy
#20
REVIEW
Radu Rusu, Sauid Ishaq, Terry Wong, Jason M Dunn
The cervical inlet patch is an island of heterotopic gastric mucosa, most commonly found in the proximal oesophagus. Its importance as a cause of throat symptoms has been recognised, particularly chronic globus sensation. This has led to a change in the Rome IV criteria for globus management, with emphasis on ruling out the condition. Proton pump inhibitors are often ineffective in resolving symptoms. Endoscopic studies on the use of ablative techniques, most recently radiofrequency ablation (RFA), have shown promise in reversing the CIP to mormal squamous mucosa, with subsequent symtpomatic resolution...
July 2018: Frontline Gastroenterology
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