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Frontline Gastroenterology

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https://www.readbyqxmd.com/read/30047549/golimumab-early-experience-and-medium-term-outcomes-from-two-uk-tertiary-ibd-centres
#1
Mark A Samaan, Polychronis Pavlidis, Jonathan Digby-Bell, Emma L Johnston, Angad Dhillon, Ramesh Paramsothy, Abisoye O Akintimehin, Lucy Medcalf, Guy Chung-Faye, Patrick DuBois, Ioannis Koumoutsos, Nick Powell, Simon H C Anderson, Jeremy Sanderson, Bu' Hussain Hayee, Peter M Irving
Objective: To gain an understanding of the effectiveness of golimumab in a 'real-world' setting. Design: Retrospective cohort study using prospectively maintained clinical records. Setting: Two UK tertiary IBD centres. Patients: Patients with ulcerative colitis (UC) were given golimumab at Guy's & St Thomas and King's College Hospitals between September 2014 and December 2016. Intervention: Golimumab, a subcutaneously administered antitumour necrosis factor agent...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30047548/golimumab-for-ulcerative-colitis-adding-perspective-to-the-pursuit
#2
EDITORIAL
Jimmy K Limdi
No abstract text is available yet for this article.
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046429/associations-between-diagnostic-pathways-and-care-experience-in-colorectal-cancer-evidence-from-patient-reported-data
#3
Theodosia Salika, Gary A Abel, Silvia C Mendonca, Christian von Wagner, Cristina Renzi, Annie Herbert, Sean McPhail, Georgios Lyratzopoulos
Objective: To examine how different pathways to diagnosis of colorectal cancer may be associated with the experience of subsequent care. Design: Patient survey linked to information on diagnostic route.English patients with colorectal cancer (analysis sample n=6837) who responded to a patient survey soon after their hospital treatment. Main outcome measures: Odds Ratios and adjusted proportions of negative evaluation of key aspects of care for colorectal cancer, including the experience of shared decision-making about treatment, specialist nursing and care coordination, by diagnostic route (ie, screening detection, emergency presentation, urgent and elective general practitioner referral)...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046428/challenges-in-screening-for-latent-tuberculosis-in-inflammatory-bowel-disease-prior-to-biologic-treatment-a-uk-cohort-study
#4
Aye Aye Thi, Aula Abbara, Sonia Bouri, Simon M Collin, Paul Wolfson, Leah Owen, Kevin G Buell, Laurence John, Ailsa L Hart
Objective: The aim of this study was to determine the occurrence of latent tuberculosis infections (LTBI) and active TB in a cohort of patients with inflammatory bowel disease (IBD) treated with biologics. We also examined the effects of immunosuppressive drugs on indeterminate interferon-gamma release assays (IGRA) in LTBI screening. Design: Retrospective study of patients treated with biologics between March 2007 and November 2015. Setting: St Mark's Hospital, North West London, UK...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046427/cervical-inlet-patch-new-insights-into-diagnosis-and-endoscopic-therapy
#5
REVIEW
Radu Rusu, Sauid Ishaq, Terry Wong, Jason M Dunn
The cervical inlet patch is an island of heterotopic gastric mucosa, most commonly found in the proximal oesophagus. Its importance as a cause of throat symptoms has been recognised, particularly chronic globus sensation. This has led to a change in the Rome IV criteria for globus management, with emphasis on ruling out the condition. Proton pump inhibitors are often ineffective in resolving symptoms. Endoscopic studies on the use of ablative techniques, most recently radiofrequency ablation (RFA), have shown promise in reversing the CIP to mormal squamous mucosa, with subsequent symtpomatic resolution...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046426/endoscopic-therapy-for-upper-gastrointestinal-bleeding-less-is-more
#6
Baldwin P M Yeung, Carol Craig, John Morris, Andrew Christie, Ram Kasthuri, Wesley Stuart, Adrian J Stanley
No abstract text is available yet for this article.
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046425/managing-a-patient-with-globus-pharyngeus
#7
Philip R Harvey, Byron T Theron, Nigel J Trudgill
A woman aged 47 years reported the feeling of a lump in her throat for the past year. The sensation was present intermittently and usually improved when she ate. She noted it was worse with dry swallows when she felt like a tablet was stuck in her throat. The sensation had become more persistent in recent weeks leading her to worry that she had cancer. She had no cough, sore throat or hoarseness. There were no precipitating factors and no symptoms of weight loss, dysphagia, odynophagia or change in her voice...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046424/trends-in-uk-endoscopy-training-in-the-bsg-trainees-national-survey-and-strategic-planning-for-the-future
#8
Sujata Biswas, Laith Alrubaiy, Louise China, Melanie Lockett, Antony Ellis, Neil Hawkes
Background: Improvements in the structure of endoscopy training programmes resulting in certification from the Joint Advisory Group in Gastrointestinal Endoscopy have been acknowledged to improve training experience and contribute to enhanced colonoscopy performance. Objectives: The 2016 British Society of Gastroenterology trainees' survey of endoscopy training explored the delivery of endoscopy training - access to lists; level of supervision and trainee's progression through diagnostic, core therapy and subspecialty training...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046423/paradigm-shift-should-the-elderly-undergo-propofol-sedation-for-dbe-a-prospective-cohort-study
#9
Hey-Long Ching, Federica Branchi, David S Sanders, David Turnbull, Reena Sidhu
Objective: Evaluate the safety of propofol-assisted double balloon enteroscopy (DBE) in elderly patients against a younger cohort. Design: Prospective cohort study. Setting: All patients undergoing DBE over a 30-month period were recruited at our tertiary centre. Patients: 215 procedures in 161 patients were performed. An age cut-off of 65 years and above was used to define those who were elderly. Interventions: Patients were subcategorised into four groups: elderly or young undergoing DBE with propofol or conventional sedation (with midazolam±fentanyl)...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046422/establishing-an-anaesthetist-delivered-propofol-sedation-service-for-advanced-endoscopic-procedures-implementing-the-rca-bsg-guidelines
#10
Ian Smith, Damien Durkin, Kaw Wai Lau, Srisha Hebbar
Background: Following recommendations from the Royal College of Anaesthetists and the British Society of Gastroenterology, we report our results of propofol sedation for complex endoscopic procedures delivered by a single consultant anaesthetist over a 5-year period. Methods: A weekly session was provided in the endoscopy department for procedures that were complex or could previously not be completed successfully. Deep sedation was provided by intermittent propofol bolus doses, supplemented with fentanyl where necessary, titrated to clinical effect...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046421/use-of-intravenous-hyoscine-butylbromide-buscopan-during-gastrointestinal-endoscopy
#11
EDITORIAL
Thomas Lee, John Anderson, Siwan Thomas-Gibson, Colin Rees
No abstract text is available yet for this article.
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046420/development-and-validation-of-diagnostic-triage-criteria-for-liver-disease-from-a-minimum-data-set-enabling-the-intelligent-lft-pathway-for-the-automated-assessment-of-deranged-liver-enzymes
#12
Michael Hugh Miller, Andrew Fraser, Gillian Leggett, Alastair MacGilchrist, George Gibson, James Orr, Ewan H Forrest, Ellie Dow, William Bartlett, Chirstopher Weatherburn, Axel Laurell, Kirsty Grant, Kathryn Scott, Ronald Neville, John F Dillon
Background: Liver function tests (LFTs) are commonly abnormal; most patients with 'incidental' abnormal LFTs are not investigated appropriately and for those who are, current care pathways are geared to find an explanation for the abnormality by a lengthy process of investigation and exclusion, with costs to the patient and to the health service. Objective: To validate an intelligent automatable analysis tool (iLFT) for abnormal liver enzymes, which diagnoses common liver conditions, provides fibrosis stage and recommends management...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046419/pregnancy-associated-liver-disease-a-curriculum-based-review
#13
REVIEW
Claire Kelly, Marinos Pericleous
Pregnancy is associated with changes in normal physiology, including changes to the normal parameters for blood tests. Abnormal liver function tests are a common reason for referral to gastroenterology. However, in the pregnant patient, there are unique potential causes. It is of prime importance to be aware of pregnancy-specific liver diseases as they can be serious and progress rapidly affecting outcomes for both the mother and fetus. Here, we provide an overview of the manifestations of pregnancy-related liver diseases and discuss their potential consequences...
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/30046418/multiple-symptoms-multiple-systems
#14
Anton V Emmanuel
No abstract text is available yet for this article.
July 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29588848/the-2018-dr-falk-pharma-uk-core-awards-are-open-for-applications
#15
Alice Kington
No abstract text is available yet for this article.
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29588847/impact-and-cost-effectiveness-of-formal-gastroenterology-outpatient-referral-clinical-assessment-service
#16
Stavroula Pelitari, Charlotte Hathaway, Dean Gritton, Andrea Smith, David Bush, Shyam Menon, Brian McKaig
Objective: The aim was to assess the financial and operational impact of our new gastroenterology referral pathway model on our services. Design: An electronic 'Clinical Assessment Service' (CAS) proforma and an information platform were developed, and all data were analysed retrospectively. Setting: Royal Wolverhampton NHS Trust. Patients: 14 245 general practitioner (GP) referrals were received during January 2014-December 2016 with 9773 of them being triaged via our CAS...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29588846/long-term-follow-up-of-the-use-of-maintenance-antibiotic-therapy-for-chronic-antibiotic-dependent-pouchitis
#17
Jonathan P Segal, Stephanie X Poo, Simon D McLaughlin, Omar D Faiz, Susan K Clark, Ailsa L Hart
Objective: Restorative proctolectomy is considered the procedure of choice in patients with ulcerative colitis who have failed medical therapy. Chronic pouchitis occurs in 10%-15% of patients, which often require long-term antibiotics to alleviate symptoms. Safety and efficacy of long-term maintenance antibiotics for chronic pouchitis has yet to be established. We aimed to assess the long-term safety and efficacy of maintenance antibiotic therapy for chronic pouchitis. Design: This was an observational study...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29588845/pedunculated-polyp-of-the-ileum-protruding-from-a-large-diverticulum
#18
REVIEW
Yugo Iwaya, Corwyn Rowsell, Teodor Grantcharov, Norman E Marcon
Introduction: A 52-year-old woman presented with iron deficiency anaemia and postprandial right lower quadrant pain. Abdominal examination was unremarkable and laboratory results showed mild anaemia (haemoglobin 11.3 g/dL). Upper and lower endoscopies did not reveal any source of bleeding. Video capsule endoscopy was performed which showed a large polypoid lesion in the mid-ileum (figure 1). Abdominal contrast enhanced CT demonstrated a heterogeneously enhancing pedunculated polyp measuring approximately 6 cm (figure 2)...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29588844/tacrolimus-therapy-in-moderate-to-subacute-ulcerative-proctocolitis-a-large-single-centre-cohort-study
#19
Aamir Saifuddin, Adam Harris
Objective: To explore the 'real world' effectiveness of tacrolimus therapy for refractory ulcerative proctocolitis (UC). Design: Retrospective cohort study using prospectively collated clinical data. Setting: A single district general hospital in Kent, UK. Clinical decisions and regular monitoring were undertaken by a single expert in inflammatory bowel disease. Patients: All patients started on tacrolimus between January 2010 and August 2016 at Tunbridge Wells Hospital...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29588843/protracted-severe-systemic-cytomegalovirus-disease-in-an-immunosuppressed-patient-with-ulcerative-colitis
#20
Matthew James Armstrong, Tom Thomas, Tariq Iqbal, Ralph Boulton, Jason Goh
A 33-year-old man with ulcerative colitis presented with 5-day history of fever, night sweats, abdominal pain and increased stool frequency. He was on mesalazine M/R 1 g once daily, 6-mercaptopurine (6-MP) 75 mg once daily and prednisolone 40 mg once daily. Examination revealed fever and tachycardia. Blood examinations identified a persistent leucopenia, C reactive protein of 23 mg/L and an initial alanine transaminase of 855 IU/L. Flexible sigmoidoscopy revealed well-demarcated, punched-out ulcers in the proximal rectum and distal sigmoid, with histology pathognomonic of cytomegalovirus (CMV)...
April 2018: Frontline Gastroenterology
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