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Journal of Hepato-biliary-pancreatic Sciences

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https://www.readbyqxmd.com/read/28064462/value-of-apparent-diffusion-coefficient-prior-to-neoadjuvant-therapy-is-a-predictor-of-histologic-response-in-patients-with-borderline-resectable-pancreatic-carcinoma
#1
Ken-Ichi Okada, Seiko Hirono, Manabu Kawai, Motoki Miyazawa, Atsushi Shimizu, Yuji Kitahata, Masaki Ueno, Shinya Hayami, Fumiyoshi Kojima, Hiroki Yamaue
BACKGROUND/PURPOSE: The parameters to predict histological response to neoadjuvant therapy remain controversial in borderline resectable pancreatic carcinoma (BRPC). METHODS: Twenty-four patients who underwent diffusion-weighted magnetic resonance imaging (DW-MRI) prior to expected neoadjuvant chemo/chemoradiotherapy and surgery were reviewed retrospectively. Analyses for correlation between percent tumor cell destruction and the following was performed to investigate the parameter and cut off value: tumor size, whole tumor apparent diffusion coefficient (ADC) value of DW-MRI, maximum standardized uptake value of (18) F-fluorodeoxyglucose positron emission tomography, carbohydrate antigen 19-9, and their change ratios...
January 8, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28064441/analysis-of-the-origin-of-anaplastic-pancreatic-cancer-and-the-mechanism-of-its-dedifferentiation
#2
Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Go Ohira, Kohei Nishio, Naoki Kametani, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: We researched the origin and progression of anaplastic pancreatic cancer (APC) from the viewpoints of cell lineage, epithelial-mesenchymal transition (EMT) and cancer stem like cells (CSC). METHODS: Using specimens from patients with APC and differentiated pancreatic ductal adenocarcinoma (PDAC), expression of sex-determining region Y box 9 (SOX9), E-cadherin, vimentin, ZEB-1, Snail, N-cadherin, CD24 and CD44 was estimated using immunohistochemistry...
January 8, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28054751/the-prevention-of-pancreatic-fistula-using-polyethylene-glycolic-acid-mesh-reinforcement-around-pancreatojejunostomy-the-propensity-score-matched-analysis
#3
Jae Seung Kang, Youngmin Han, Hongbeom Kim, Wooil Kwon, Sun-Whe Kim, Jin-Young Jang
BACKGROUND/PURPOSE: Several small-scale studies have shown that wrapping polyethylene glycolic acid (PGA) mesh around the anastomotic site reinforced pancreaticojejunostomy following pancreatoduodenectomy (PD) with favorable outcomes. This study investigated the efficacy of PGA mesh for reducing postoperative pancreatic fistula (POPF) and evaluated other risk factors for POPF. METHODS: This study enrolled 464 consecutive patients who underwent PD performed by one surgeon between 2006 and 2015, including a PGA group of 281 patients (60...
January 5, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28054747/bilobar-versus-unilobar-multiple-colorectal-liver-metastases-a-propensity-score-analysis-of-surgical-outcomes-and-recurrence-patterns
#4
Yasuyuki Fukami, Yuji Kaneoka, Atsuyuki Maeda, Yuichi Takayama, Takamasa Takahashi, Shunsuke Onoe, Masahito Uji, Kenji Wakai
BACKGROUND: Bilobar multiple colorectal liver metastases (MCLM) are often considered incurable or associated with a poor prognosis even after R0 resection. This study was designed to compare the long-term outcomes and recurrence patterns after one-stage resection in patients with bilobar versus unilobar MCLM. METHODS: The records of patients undergoing parenchymal-sparing intent hepatectomy between 1994 and 2015 were reviewed. Survival and recurrence patterns were analyzed by propensity score matching...
January 5, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28026137/the-right-way-is-not-always-popular-comparison-of-surgeons-perceptions-during-laparoscopic-cholecystectomy-for-acute-cholecystitis-among-experts-from-japan-korea-and-taiwan
#5
T Hibi, Y Iwashita, T Ohyama, G Honda, M Yoshida, T Takada, H S Han, T L Hwang, S Shinya, K Suzuki, A Umezawa, Y S Yoon, I S Choi, W S W Huang, K H Chen, F Miura, M Watanabe, Y Abe, T Misawa, Y Nagakawa, D S Yoon, J Y Jang, H C Yu, K S Ahn, S C Kim, I S Song, J H Kim, S S Yunv, S H Choi, Y Y Jan, S M Sheen-Chen, Y S Shan, C G Ker, D C Chan, C C Wu, N Toyota, R Higuchi, Y Nakamura, Y Mizuguchi, Y Takeda, M Ito, S Norimizu, S Yamada, N Matsumura, J Shindoh, H Sunagawa, T Gocho, H Hasegawav, T Rikiyama, N Sata, N Kano, S Kitano, H Tokumura, Y Yamashita, G Watanabe, K Nakagawa, T Kimura, T Yamakawa, G Wakabayashi, I Endo, M Miyazakiv, M Yamamoto
BACKGROUND: Generally, surgeons' perceptions of surgical safety are based on experience and institutional policy. Our recent pilot survey demonstrated that the acceptable duration of surgery and criteria for open conversion during laparoscopic cholecystectomy (LC) vary among workplaces. METHODS: A web-based survey was distributed to 554 expert LC surgeons in Japan, Korea, and Taiwan. The questionnaire covered LC experience, safety measures and recognition of landmarks, decision-making regarding conversion to open/partial cholecystectomy and the implications of this decision...
December 26, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28012285/randomized-clinical-trial-of-biclamp-%C3%A2-forceps-versus-clamp-crushing-technique-in-open-liver-resection
#6
Jiang Ming Chen, Wei Geng, Song Zhang, Fu Bao Liu, Hong Chuan Zhao, Yi Jun Zhao, Guo Bin Wang, Sheng Xue Xie, Xiao Ping Geng
PURPOSE: The aim of this trial was to compare the efficacy and safety of BiClamp(®) forceps with the "gold-standard" clamp-crushing technique for open liver resection. METHODS: From October 2014 to May 2016, 86 consecutive patients scheduled to undergo hepatic resection were randomized to a BiClamp(®) forceps group (n=43) or to a clamp-crushing technique group (n=43). RESULTS: Background characteristics of the two groups were closely matched...
December 24, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28012284/validity-of-the-barcelona-clinic-liver-cancer-and-hong-kong-liver-cancer-staging-system-for-hepatocellular-carcinoma-in-singapore
#7
Li Kim E Selby, Rosanna X Y Tay, Winston W L Woon, Jee Keem Low, Wang Bei, Vishalkumar G Shelat, Tony C Y Pang, Sameer P Junnarkar
In the management of hepatocellular carcinomas (HCC), staging of the disease plays a vital part. Many groups have developed different staging systems that can be adopted for the management of HCC. Although numerous comparisons have been made, because of patient selection criteria and disease heterogeneity, there is currently no worldwide consensus on the use of any given model as the standard for classifying HCC. The reason for differences in approach to HCC can certainly be attributed to the inherent clinical and biological heterogeneity, but can also be attributed to differences in how clinicians and researchers view the cancer...
December 24, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28008721/therapy-of-primary-and-metastatic-liver-cancer-by-human-ips-cell-derived-myeloid-cells-producing-interferon-%C3%AE
#8
Masataka Sakisaka, Miwa Haruta, Yoshihiro Komohara, Satoshi Umemoto, Keiko Matsumura, Tokunori Ikeda, Motohiro Takeya, Yukihiro Inomata, Yasuharu Nishimura, Satoru Senju
BACKGROUND: iPS-ML are myeloid lineage cells with a proliferative capacity derived from induced pluripotent stem (iPS) cells. This study aimed to examine therapeutic effect of iPS-ML producing interferon-β (iPS-ML/IFN-β) towards primary and metastatic liver cancer and investigate the mechanism of that effect. METHODS: We established a xenograft model of liver metastasis by injecting the spleen of SCID mice with MKN-45 human gastric cancer cells and also a primary liver cancer model by injecting SK-HEP-1 human hepatocellular carcinoma cells into the liver...
December 23, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28002655/optimal-dosage-regimen-for-rituximab-in-abo-incompatible-living-donor-liver-transplantation
#9
Hiroto Egawa, Koji Umeshita, Shinji Uemoto
BACKGROUND: Rituximab has greatly improved the outcomes of ABO-incompatible living donor liver transplantation (ABO-I LDLT). To clarify the optimal regimen for rituximab in adult ABO-I LDLT, a multicenter study was conducted in Japan. METHODS: Clinical data of 33 adult patients undergoing ABO-I LDLT at 15 centers in 2013 were retrospectively corrected. RESULTS: The targeted blood type was A1 in 18, B in 14, and AB in 1 patient. Rituximab was administered at 7 to 48 days before LT, at a dose of 375 mg/m(2) in 12 patients, 500 mg in 15 patients, 300 mg in 5 patients, and 100 mg in 1 patient...
December 21, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28002647/il-7-and-procalcitonin-are-useful-biomarkers-in-the-comprehensive-evaluation-of-the-severity-of-acute-cholangitis
#10
Yusuke Suwa, Ryusei Matsuyama, Koki Goto, Toshiaki Kadokura, Mari Sato, Ryutaro Mori, Takafumi Kumamoto, Masataka Taguri, Taku Miyasho, Itaru Endo
BACKGROUND: The incidence of biliary tract infection (BTI), especially healthcare-associated cholangitis, is increasing. However, there are few reports concerning biomarkers of acute cholangitis. We therefore performed an exhaustive investigation of several biomarkers. METHODS: We retrospectively measured eleven cytokines, six chemokines and procalcitonin (PCT), and endotoxin activity assay (EAA) values (IRB: 110512019) of sixty-one samples with acute cholangitis...
December 21, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28002646/elevated-bile-amylase-level-without-pancreaticobiliary-maljunction-is-a-risk-factor-for-gallbladder-carcinoma
#11
Takaaki Fujimoto, Takao Ohtsuka, Yohei Nakashima, Yoshitaka Gotoh, Kenjiro Date, Yasuhisa Mori, Yoshihiko Sadakari, Shunichi Takahata, Yoshinao Oda, Masafumi Nakamura
BACKGROUND: Elevated bile amylase level in patients with pancreaticobiliary maljunction (PBM) or high confluence of pancreaticobiliary ducts (HCPBD) is well known as a risk factor for gallbladder carcinoma (GBC) development. However, the effects of occult pancreaticobiliary reflux (OPR), a condition characterized by high bile amylase level in the presence of an anatomically normal pancreaticobiliary junction, on GBC development remain unclear. The aim of this study was to assess the relationship between OPR and GBC...
December 21, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27926987/impact-of-everolimus-on-japanese-patients-with-advanced-pancreatic-neuroendocrine-neoplasms
#12
Lingaku Lee, Tetsuhide Ito, Hisato Igarashi, Keijiro Ueda, Takashi Fujiyama, Ken Kawabe, Yoshihiro Ogawa
BACKGROUND: Although everolimus has become a key therapeutic agent in patients with advanced pancreatic neuroendocrine neoplasms (PNEN), its efficacy and safety in clinical practice remains unclear. METHODS: Forty-seven patients with advanced PNEN treated with everolimus were reviewed retrospectively. To evaluate the safety of everolimus as a long-term treatment, the patients were divided into 2 groups according to treatment duration: group A, ≤1 year (n = 21); group B, >1 year (n = 26)...
December 7, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27860361/evaluation-of-the-risk-factors-and-prognostic-factors-of-hepatectomy-for-hepatocellular-carcinoma-in-patients-aged-80-years-or-more
#13
Michinori Hamaoka, Tsuyoshi Kobayashi, Kohei Ishiyama, Masahiro Ohira, Hiroyuki Tahara, Shintaro Kuroda, Hiroshi Iwako, Sho Okimoto, Naruhiko Honmyo, Hideki Ohdan
BACKGROUND/PURPOSE: The risk factors of postoperative complications and prognostic factors of hepatocellular carcinoma in patients aged ≥80 years have not yet been defined. We aimed to identify these factors in this patient population. METHODS: This single-center, retrospective cohort study included 625 patients who underwent curative hepatectomy from January 2004 to December 2013. Elderly patients were defined as those aged ≥80 years. Clinicopathological data and outcomes after hepatectomy for 60 elderly patients and 565 non-elderly patients were compared...
November 18, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27806426/significance-of-preoperative-fluorodeoxyglucose-positron-emission-tomography-in-prediction-of-tumor-recurrence-after-liver-transplantation-for-hepatocellular-carcinoma-patients-a-japanese-multicenter-study
#14
Yasutsugu Takada, Toshimi Kaido, Ken Shirabe, Hiroaki Nagano, Hiroto Egawa, Yasuhiko Sugawara, Akinobu Taketomi, Takeshi Takahara, Go Wakabayashi, Chikashi Nakanishi, Naoki Kawagishi, Akira Kenjo, Mitsukazu Gotoh, Yoshikazu Toyoki, Kenichi Hakamada, Masayuki Ohtsuka, Nobuhisa Akamatsu, Norihiro Kokudo, Kazuhisa Takeda, Itaru Endo, Hiroyuki Takamura, Hideaki Okajima, Hiroshi Wada, Shoji Kubo, Kaoru Kuramitsu, Yonson Ku, Kohei Ishiyama, Hideki Ohdan, Eitaro Ito, Yoshihiko Maehara, Masaki Honda, Yukihiro Inomata, Hiroyuki Furukawa, Shinji Uemoto, Hiroki Yamaue, Masaru Miyazaki, Tadahiro Takada
BACKGROUND/AIMS: In the present study, we conducted a multicenter nationwide survey to investigate the effects of preoperative fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) on the prediction of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). METHODS: From 16 Japanese LT centers, data were collected on 182 recipients with HCC who underwent living donor liver transplantation (LDLT) between February 2005 and November 2013...
November 2, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27794204/perioperative-outcomes-and-survival-in-elderly-patients-undergoing-laparoscopic-distal-pancreatectomy
#15
Mushegh A Sahakyan, Bjørn Edwin, Airazat M Kazaryan, Leonid Barkhatov, Trond Buanes, Dejan Ignjatovic, Knut Jørgen Labori, Bård Ingvald Røsok
BACKGROUND: The outcomes following laparoscopic distal pancreatectomy (LDP) in elderly have not been widely reported to date. This study aimed to analyze perioperative and oncologic outcomes in patients aged ≥70 years (elderly group) and those < 70 years (non-elderly group). METHODS: From April 1997 to September 2015, 402 consecutive patients with lesions in the body and tail of the pancreas underwent LDP at Rikshospitalet, Oslo University Hospital...
October 29, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27871128/hand-assisted-laparoscopic-left-hepatectomy-how-i-do-it
#16
Susannah M Cheek, Iswanto Sucandy, David A Geller
Laparoscopic liver resection has been adopted slowly due to concerns for bleeding and oncologic outcomes. Currently, over 9,500 laparoscopic liver resections have been performed and reported worldwide. Numerous studies have shown the safety and oncologic equivalence of laparoscopic liver resection when compared to open resection. Pure laparoscopic and hand-assisted laparoscopic liver resection are the two most commonly used techniques for minimally invasive liver resection surgery. Advantages of the hand-port include tactile feedback, facilitation of liver mobilization, and ease of ability to control bleeding...
December 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27794194/risk-factors-for-latent-distant-organ-metastasis-detected-by-staging-laparoscopy-in-patients-with-radiologically-defined-locally-advanced-pancreatic-ductal-adenocarcinoma
#17
Ilhan Karabicak, Sohei Satoi, Hiroaki Yanagimoto, Tomohisa Yamamoto, Satoshi Hirooka, So Yamaki, Hisashi Kosaka, Kentaro Inoue, Yoichi Matsui, Masanori Kon
OBJECTIVES: We aimed to identify risk factors for latent distant organ metastasis in patients with radiographically defined locally advanced (RDLA) pancreatic ductal adenocarcinoma (PDAC). METHODS: RDLA disease was defined as unresectable disease without distant organ metastasis based on resectability status by NCCN guidelines. Between January 2005 and November 2015, 110 consecutive patients underwent staging laparoscopy to rule out latent distant metastasis. Univariate and multivariate analyses were performed to identify risk factors for latent distant organ metastasis or peritoneal metastasis (PM), defined as peritoneal dissemination and/or positive peritoneal lavage cytology (PPC)...
December 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27766758/training-in-hepato-pancreato-biliary-surgery-during-residency-past-present-and-future-perspectives
#18
REVIEW
Martin de Santibañes, Eduardo de Santibañes, Juan Pekolj
The paradigm introduced by William Halsted for surgical residency training has been considered the most appropriate educational system to acquire the knowledge and surgical skills required to become a competent general surgeon. Hepato-pancreato-biliary (HPB) surgery is considered an important part of general surgery training because of its high prevalence and complexity. Nowadays, we are faced with a worldwide shortage of general surgeons candidates, restrictive working hours and less surgical exposure, situations that can undermine the objectives of training in HPB surgery during residency...
December 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27734596/longer-warm-ischemia-can-accelerate-tumor-growth-through-the-induction-of-hif-1%C3%AE-and-the-il-6-jak-stat3-signaling-pathway-in-a-rat-hepatocellular-carcinoma-model
#19
Yuhei Hamaguchi, Akira Mori, Yasuhiro Fujimoto, Takashi Ito, Taku Iida, Shintaro Yagi, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
BACKGROUND: The present study aimed to investigate the impact of the duration of hepatic pedicle clamping (HPC) on tumor growth after major hepatectomy in a rat model. METHODS: Rats were divided into four groups according to the length of HPC during 70% partial hepatectomy followed by N1S1 tumor cell implantation: group 1, without HPC; group 2, with 5-min HPC; group 3, 10-min HPC; and group 4, 15-min HPC. At three weeks after tumor cell implantation, liver tumor growth and its possible mechanisms were investigated...
December 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27734589/mesopancreas-is-a-misnomer-time-to-correct-the-nomenclature
#20
REVIEW
Dhananjaya Sharma, Shuji Isaji
Focused pathological attention to tumor invasion of the retroperitoneal resection margin after pancreaticoduodenectomy for cancer of head of the pancreas led to the knowledge of strong tendency of cancer cells to infiltrate into the retropancreatic tissue and to spread along the peripancreatic neural plexuses as the cause of local recurrence. The term 'mesopancreas' was coined to describe perineural lymphatic layer located dorsally to the pancreas and it was suggested that its complete resection will minimize loco-regional recurrence and improve outcome...
December 2016: Journal of Hepato-biliary-pancreatic Sciences
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