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Journal of Hepato-biliary-pancreatic Sciences

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https://www.readbyqxmd.com/read/28196311/an-opportunity-in-difficulty-japan-korea-taiwan-expert-delphi-consensus-on-surgical-difficulty-during-laparoscopic-cholecystectomy
#1
Yukio Iwashita, Taizo Hibi, Tetsuji Ohyama, Goro Honda, Masahiro Yoshida, Fumihiko Miura, Tadahiro Takada, Ho-Seong Han, Tsann-Long Hwang, Satoshi Shinya, Kenji Suzuki, Akiko Umezawa, Yoo-Seok Yoon, In-Seok Choi, Wayne Shih-Wei Huang, Kuo-Hsin Chen, Manabu Watanabe, Yuta Abe, Takeyuki Misawa, Yuichi Nagakawa, Dong-Sup Yoon, Jin-Young Jang, Hee Chul Yu, Keun Soo Ahn, Song Cheol Kim, In Sang Song, Ji Hoon Kim, Sung-Su Yun, Seong Ho Choi, Yi-Yin Jan, Yan-Shen Shan, Chen-Guo Ker, De-Chuan Chan, Cheng-Chung Wu, King-Teh Lee, Naoyuki Toyota, Ryota Higuchi, Yoshiharu Nakamura, Yoshiaki Mizuguchi, Yutaka Takeda, Masahiro Ito, Shinji Norimizu, Shigetoshi Yamada, Naoki Matsumura, Junichi Shindoh, Hiroki Sunagawa, Takeshi Gocho, Hiroshi Hasegawa, Toshiki Rikiyama, Naohiro Sata, Nobuyasu Kano, Seigo Kitano, Hiromi Tokumura, Yuichi Yamashita, Goro Watanabe, Kunitoshi Nakagawa, Taizo Kimura, Tatsuo Yamakawa, Go Wakabayashi, Rintaro Mori, Itaru Endo, Masaru Miyazaki, Masakazu Yamamoto
BACKGROUND: We previously identified 25 intraoperative findings during laparoscopic cholecystectomy (LC) as potential indicators of surgical difficulty per nominal group technique. This study aimed to build a consensus among expert LC surgeons on the impact of each item on surgical difficulty. METHODS: Surgeons from Japan, Korea, and Taiwan (n = 554) participated in a Delphi process and graded the 25 items on a seven-stage scale (range, 0-6). Consensus was defined as (i) the interquartile range (IQR) of overall responses ≤2 and (ii) ≥66% of the responses concentrated within a median ± 1 after stratification by workplace and LC experience level...
February 14, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28196310/gemcitabine-cisplatin-versus-gemcitabine-oxaliplatin-doublet-chemotherapy-in-advanced-gallbladder-cancers-a-match-pair-analysis
#2
Anant Ramaswamy, Vikas Ostwal, Rakesh Pinniti, Sadhana Kannan, Prabhat Bhargava, Chaitali Nashikkar, Jimmy Mirani, Shripad Banavali
BACKGROUND: Gemcitabine-cisplatin (GC) and gemcitabine-oxaliplatin (GO) are the most commonly used regimens in advanced gallbladder cancer (GBC). METHODS: The data of patients with advanced GBC, treated between January 2013 and June 2015 were retrieved. A 1:1 matching without replacement was performed by using nearest neighbour matching method. RESULTS: 326 patients (163 GC and 163 GO), were matched 1:1 by age and gender. The response rates for GC and GO were 31...
February 14, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28196308/risk-factors-of-serious-postoperative-complications-after-pancreaticoduodenectomy-and-risk-calculators-for-predicting-postoperative-complications-a-nationwide-study-of-17-564-patients-in-japan
#3
Shuichi Aoki, Hiroaki Miyata, Mitsukazu Gotoh, Fuyuhiko Motoi, Hiraku Kumamaru, Hiroyuki Konno, Go Wakabayashi, Yoshihiro Kakeji, Masaki Mori, Yasuyuki Seto, Michiaki Unno
BACKGROUND: The morbidity rate after pancreaticoduodenectomy remains high. The objectives of this retrospective cohort study were to clarify the risk factors associated with serious morbidity (Clavien-Dindo classification grades IV-V), and create complication risk calculators using the Japanese National Clinical Database. METHODS: Between 2011 and 2012, data from 17564 patients who underwent pancreaticoduodenectomy at 1311 institutions in Japan were recorded in this database...
February 14, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28185429/tips-for-pure-laparoscopic-right-hepatectomy-in-the-live-donor
#4
Olivier Soubrane, Choon Hyuck David Kwon
Donor right hepatectomy is a technically complex and challenging procedure. It is one of the most debated applications of laparoscopy and donor safety is the main concern. The technique described herein uses pure laparoscopic approach with five trocars. After mobilization of the right liver, the right hepatic artery and portal vein are dissected. The liver parenchyma is then divided using an ultrasonic aspirator and an energy device. The middle hepatic vein is kept intact with the left remaining liver. Intra-operative cholangiography allows to determine a safe site for right bile duct division...
February 9, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28181419/anterior-approach-for-right-hepatectomy-with-hanging-maneuver-for-hepatocellular-carcinoma-a-multi-institutional-propensity-score-matching-study
#5
Toru Beppu, Katsunori Imai, Koji Okuda, Susumu Eguchi, Kenji Kitahara, Nobuhiko Taniai, Shinichi Ueno, Ken Shirabe, Masayuki Ohta, Kazuhiro Kondo, Atsushi Nanashima, Tomoaki Noritomi, Masayuki Shiraishi, Yuko Takami, Kohji Okamoto, Ken Kikuchi, Hideo Baba, Hikaru Fujioka
BACKGROUND /PURPOSE: This multi-institutional study was aimed to assess the benefits of anterior approach for right hepatectomy with hanging maneuver (ARH-HM) for hepatocellular carcinoma (HCC) compared with conventional right hepatectomy (CRH). METHODS: From January 2000 to December 2012, 306 patients with HCC ≥ 5 cm were divided into two groups: ARH-HM (n = 104) and CRH (n = 202). RESULTS: After one-to-one propensity score-matched analysis, 72 ARH-HM and 72 CRH patients presented comparable background factors...
February 9, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28160422/survival-benefit-of-hepatic-resection-for-hepatocellular-carcinoma-beyond-the-barcelona-clinic-liver-cancer-classification
#6
Kenei Furukawa, Hiroaki Shiba, Takashi Horiuchi, Yoshihiro Shirai, Koichiro Haruki, Yuki Fujiwara, Taro Sakamoto, Takeshi Gocho, Katsuhiko Yanaga
BACKGROUND: The Barcelona Clinic Liver Cancer (BCLC) classification is the most widely used staging system for hepatocellular carcinoma (HCC), but its prognostic ability in patients after resection has not been yet validated. The aim of this study was to evaluate the BCLC classification among patients after resection. METHODS: The subjects were 196 patients who underwent hepatic resection for HCC between April 2003 and December 2014 at Jikei University Hospital...
February 3, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28111910/japanese-clinical-practice-guidelines-for-congenital-biliary-dilatation
#7
LETTER
Hiroki Ishibashi, Mitsuo Shimada, Terumi Kamisawa, Hideki Fujii, Yoshinori Hamada, Masayuki Kubota, Naoto Urushihara, Itaru Endo, Masaki Nio, Tomoaki Taguchi, Hisami Ando
Until now, there have been no practical clinical guidelines for congenital biliary dilatation (CBD). In this review article, the Japanese Study Group on Congenital Biliary Dilatation (JSCBD) propose to establish clinical practice guidelines for CBD. Because the evidence-based literature is relatively small, we decided to create guidelines based on the consensus of experts, using the medical literature for reference. A total of 20 clinical questions (CQs) were considered by the members of the editorial committee responsible for the guidelines...
January 22, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28107613/variant-outcomes-of-liver-transplantation-for-hepatitis-c-virus-patients-in-different-age-categories-impact-of-the-meld-score
#8
Zhenhua Hu, Jie Zhou, Zhiwei Li, Jie Xiang, Qijun Zhang, Sheng Yan, Jian Wu, Min Zhang, Weilin Wang, Shusen Zheng
BACKGROUND: Whether the introduction of model for end-stage liver disease (MELD) has an effect on transplant outcome for different age categories remain unclear. METHODS: We analyzed 49,762 adult hepatitis C virus (HCV) candidates through 1995-01-01 to 2012-12-31 from the Scientific Registry of Transplant Recipients. Patients were divided into four age categories (18-34 yr, 35-49 yr, 60-64 yr, ≥65 yr) in the pre-MELD era and MELD era respectively. RESULTS: Waiting list dropouts have decreased in the MELD era for all categories...
January 20, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28103424/no-negative-impact-of-serum-igg4-levels-on-clinical-outcome-in-435-patients-with-primary-sclerosing-cholangitis-from-japan
#9
Atsushi Tanaka, Susumu Tazuma, Takahiro Nakazawa, Hiroyuki Isayama, Toshio Tsuyuguchi, Kazuo Inui, Hajime Takikawa
BACKGROUND AND AIMS: Several studies have demonstrated that elevated serum IgG4 levels are associated with poor outcomes of primary sclerosing cholangitis (PSC), but the impact of serum IgG4 levels on PSC remains controversial. In this study, we aimed to determine prognostic factors of patients with PSC and to investigate the association between serum IgG4 levels and the clinical features and prognosis of PSC in a Japanese cohort. METHODS: We retrospectively analysed follow-up data for 435 patients with PSC (UMIN000018438)...
January 19, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28103418/three-hundred-and-sixty-eight-consecutive-pancreaticoduodenetomies-with-zero-mortality
#10
Seiji Oguro, Jiro Yoshimoto, Hiroshi Imamura, Yoichi Ishizaki, Seiji Kawasaki
BACKGROUND/PURPOSE: Only a limited number of reports have documented zero mortality in consecutive pancreaticoduodenetomy series. The aim of this study is to review and verify our management aiming to eliminate mortality after pancreaticoduodenetomy. METHODS: Three hundred sixty-eight consecutive patients undergoing pancreaticoduodenetomy between 2002 and 2015 were retrospectively reviewed. During this period, in order to enhance the safety of pancreaticoduodenetomy, we have employed a consistent strategy consisting of early ligation of the inferior pancreatoduodenal artery, mucosal sutureless pancreaticojejunostomy combined with external pancreatic duct stenting, conditional two-stage pancreaticojejunostomy, jejunal decompression using tube jejunostomy, application of an omental flap to cover the stump of the gastroduodenal artery, and careful postoperative drain management...
January 19, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28064462/value-of-apparent-diffusion-coefficient-prior-to-neoadjuvant-therapy-is-a-predictor-of-histologic-response-in-patients-with-borderline-resectable-pancreatic-carcinoma
#11
Ken-Ichi Okada, Seiko Hirono, Manabu Kawai, Motoki Miyazawa, Atsushi Shimizu, Yuji Kitahata, Masaki Ueno, Shinya Hayami, Fumiyoshi Kojima, Hiroki Yamaue
BACKGROUND/PURPOSE: The parameters to predict histological response to neoadjuvant therapy remain controversial in borderline resectable pancreatic carcinoma (BRPC). METHODS: Twenty-four patients who underwent diffusion-weighted magnetic resonance imaging (DW-MRI) prior to expected neoadjuvant chemo/chemoradiotherapy and surgery were reviewed retrospectively. Analyses for correlation between percent tumor cell destruction and the following was performed to investigate the parameter and cut off value: tumor size, whole tumor apparent diffusion coefficient (ADC) value of DW-MRI, maximum standardized uptake value of (18) F-fluorodeoxyglucose positron emission tomography, carbohydrate antigen 19-9, and their change ratios...
January 8, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28064441/analysis-of-the-origin-of-anaplastic-pancreatic-cancer-and-the-mechanism-of-its-dedifferentiation
#12
Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Go Ohira, Kohei Nishio, Naoki Kametani, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: We researched the origin and progression of anaplastic pancreatic cancer (APC) from the viewpoints of cell lineage, epithelial-mesenchymal transition (EMT) and cancer stem like cells (CSC). METHODS: Using specimens from patients with APC and differentiated pancreatic ductal adenocarcinoma (PDAC), expression of sex-determining region Y box 9 (SOX9), E-cadherin, vimentin, ZEB-1, Snail, N-cadherin, CD24 and CD44 was estimated using immunohistochemistry...
January 8, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28054751/the-prevention-of-pancreatic-fistula-using-polyethylene-glycolic-acid-mesh-reinforcement-around-pancreatojejunostomy-the-propensity-score-matched-analysis
#13
Jae Seung Kang, Youngmin Han, Hongbeom Kim, Wooil Kwon, Sun-Whe Kim, Jin-Young Jang
BACKGROUND/PURPOSE: Several small-scale studies have shown that wrapping polyethylene glycolic acid (PGA) mesh around the anastomotic site reinforced pancreaticojejunostomy following pancreatoduodenectomy (PD) with favorable outcomes. This study investigated the efficacy of PGA mesh for reducing postoperative pancreatic fistula (POPF) and evaluated other risk factors for POPF. METHODS: This study enrolled 464 consecutive patients who underwent PD performed by one surgeon between 2006 and 2015, including a PGA group of 281 patients (60...
January 5, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28054747/bilobar-versus-unilobar-multiple-colorectal-liver-metastases-a-propensity-score-analysis-of-surgical-outcomes-and-recurrence-patterns
#14
Yasuyuki Fukami, Yuji Kaneoka, Atsuyuki Maeda, Yuichi Takayama, Takamasa Takahashi, Shunsuke Onoe, Masahito Uji, Kenji Wakai
BACKGROUND: Bilobar multiple colorectal liver metastases (MCLM) are often considered incurable or associated with a poor prognosis even after R0 resection. This study was designed to compare the long-term outcomes and recurrence patterns after one-stage resection in patients with bilobar versus unilobar MCLM. METHODS: The records of patients undergoing parenchymal-sparing intent hepatectomy between 1994 and 2015 were reviewed. Survival and recurrence patterns were analyzed by propensity score matching...
January 5, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28026137/the-right-way-is-not-always-popular-comparison-of-surgeons-perceptions-during-laparoscopic-cholecystectomy-for-acute-cholecystitis-among-experts-from-japan-korea-and-taiwan
#15
Taizo Hibi, Yukio Iwashita, Tetsuji Ohyama, Goro Honda, Masahiro Yoshida, Tadahiro Takada, Ho-Seong Han, Tsann-Long Hwang, Satoshi Shinya, Kenji Suzuki, Akiko Umezawa, Yoo-Seok Yoon, In-Seok Choi, Wayne Shih-Wei Huang, Kuo-Hsin Chen, Fumihiko Miura, Manabu Watanabe, Yuta Abe, Takeyuki Misawa, Yuichi Nagakawa, Dong-Sup Yoon, Jin-Young Jang, Hee Chul Yu, Keun Soo Ahn, Song Cheol Kim, In Sang Song, Ji Hoon Kim, Sung Su Yun, Seong Ho Choi, Yi-Yin Jan, Shyr-Ming Sheen-Chen, Yan-Shen Shan, Chen-Guo Ker, De-Chuan Chan, Cheng-Chung Wu, Naoyuki Toyota, Ryota Higuchi, Yoshiharu Nakamura, Yoshiaki Mizuguchi, Yutaka Takeda, Masahiro Ito, Shinji Norimizu, Shigetoshi Yamada, Naoki Matsumura, Junichi Shindoh, Hiroki Sunagawa, Takeshi Gocho, Hiroshi Hasegawa, Toshiki Rikiyama, Naohiro Sata, Nobuyasu Kano, Seigo Kitano, Hiromi Tokumura, Yuichi Yamashita, Goro Watanabe, Kunitoshi Nakagawa, Taizo Kimura, Tatsuo Yamakawa, Go Wakabayashi, Itaru Endo, Masaru Miyazaki, Masakazu Yamamoto
BACKGROUND: Generally, surgeons' perceptions of surgical safety are based on experience and institutional policy. Our recent pilot survey demonstrated that the acceptable duration of surgery and criteria for open conversion during laparoscopic cholecystectomy (LC) vary among workplaces. METHODS: A web-based survey was distributed to 554 expert LC surgeons in Japan, Korea, and Taiwan. The questionnaire covered LC experience, safety measures and recognition of landmarks, decision-making regarding conversion to open/partial cholecystectomy and the implications of this decision...
December 26, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28012285/randomized-clinical-trial-of-biclamp-%C3%A2-forceps-versus-clamp-crushing-technique-in-open-liver-resection
#16
Jiang Ming Chen, Wei Geng, Song Zhang, Fu Bao Liu, Hong Chuan Zhao, Yi Jun Zhao, Guo Bin Wang, Sheng Xue Xie, Xiao Ping Geng
PURPOSE: The aim of this trial was to compare the efficacy and safety of BiClamp(®) forceps with the "gold-standard" clamp-crushing technique for open liver resection. METHODS: From October 2014 to May 2016, 86 consecutive patients scheduled to undergo hepatic resection were randomized to a BiClamp(®) forceps group (n=43) or to a clamp-crushing technique group (n=43). RESULTS: Background characteristics of the two groups were closely matched...
December 24, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28012284/validity-of-the-barcelona-clinic-liver-cancer-and-hong-kong-liver-cancer-staging-systems-for-hepatocellular-carcinoma-in-singapore
#17
Li Kim E Selby, Rosanna X Y Tay, Winston W L Woon, Jee Keem Low, Wang Bei, Vishalkumar G Shelat, Tony C Y Pang, Sameer P Junnarkar
BACKGROUND: Staging is vital in guiding therapeutic approach in patients diagnosed with hepatocellular carcinoma (HCC). Our study's goal is to compare paradigms in the Barcelona Clinic Liver Cancer (BCLC) and Hong Kong Liver Cancer (HKLC) systems, and evaluate the use of both in a local context, comparing their prognostic ability and therapeutic efficacy in the management of HCC. METHODS: Seven hundred and sixty-six patients diagnosed between 2010 and 2015 were identified and staged according to BCLC and HKLC...
December 24, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28008721/therapy-of-primary-and-metastatic-liver-cancer-by-human-ips-cell-derived-myeloid-cells-producing-interferon-%C3%AE
#18
Masataka Sakisaka, Miwa Haruta, Yoshihiro Komohara, Satoshi Umemoto, Keiko Matsumura, Tokunori Ikeda, Motohiro Takeya, Yukihiro Inomata, Yasuharu Nishimura, Satoru Senju
BACKGROUND: iPS-ML are myeloid lineage cells with a proliferative capacity derived from induced pluripotent stem (iPS) cells. This study aimed to examine therapeutic effect of iPS-ML producing interferon-β (iPS-ML/IFN-β) towards primary and metastatic liver cancer and investigate the mechanism of that effect. METHODS: We established a xenograft model of liver metastasis by injecting the spleen of SCID mice with MKN-45 human gastric cancer cells and also a primary liver cancer model by injecting SK-HEP-1 human hepatocellular carcinoma cells into the liver...
December 23, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28002655/optimal-dosage-regimen-for-rituximab-in-abo-incompatible-living-donor-liver-transplantation
#19
Hiroto Egawa, Koji Umeshita, Shinji Uemoto
BACKGROUND: Rituximab has greatly improved the outcomes of ABO-incompatible living donor liver transplantation (ABO-I LDLT). To clarify the optimal regimen for rituximab in adult ABO-I LDLT, a multicenter study was conducted in Japan. METHODS: Clinical data of 33 adult patients undergoing ABO-I LDLT at 15 centers in 2013 were retrospectively corrected. RESULTS: The targeted blood type was A1 in 18, B in 14, and AB in 1 patient. Rituximab was administered at 7 to 48 days before LT, at a dose of 375 mg/m(2) in 12 patients, 500 mg in 15 patients, 300 mg in 5 patients, and 100 mg in 1 patient...
December 21, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28002647/il-7-and-procalcitonin-are-useful-biomarkers-in-the-comprehensive-evaluation-of-the-severity-of-acute-cholangitis
#20
Yusuke Suwa, Ryusei Matsuyama, Koki Goto, Toshiaki Kadokura, Mari Sato, Ryutaro Mori, Takafumi Kumamoto, Masataka Taguri, Taku Miyasho, Itaru Endo
BACKGROUND: The incidence of biliary tract infection (BTI), especially healthcare-associated cholangitis, is increasing. However, there are few reports concerning biomarkers of acute cholangitis. We therefore performed an exhaustive investigation of several biomarkers. METHODS: We retrospectively measured eleven cytokines, six chemokines and procalcitonin (PCT), and endotoxin activity assay (EAA) values (IRB: 110512019) of sixty-one samples with acute cholangitis...
December 21, 2016: Journal of Hepato-biliary-pancreatic Sciences
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