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Stem Cell Research & Therapy

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https://www.readbyqxmd.com/read/29444715/porcine-wharton-s-jelly-cells-distribute-throughout-the-body-after-intraperitoneal-injection
#1
Kreeson Packthongsuk, Theresa Rathbun, Deryl Troyer, Duane L Davis
BACKGROUND: Wharton's jelly cells (WJCs) have multiple differentiation potentials and are easily harvested in large numbers. WJCs are well tolerated in allogeneic environments and there is a growing list of their therapeutic effects. Most therapies require administering large numbers of cells and this is generally accomplished by intravenous injection. Here, we studied the locations of porcine WJCs in immune-competent, allogeneic hosts after intraperitoneal (IP) injection. METHODS: Male porcine WJCs were administered to female neonatal piglets by IP injection...
February 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29444704/hpmsc-transplantation-restoring-ovarian-function-in-premature-ovarian-failure-mice-is-associated-with-change-of-th17-tc17-and-th17-treg-cell-ratios-through-the-pi3k-akt-signal-pathway
#2
Na Yin, Yanlin Wang, Xueyan Lu, Ranran Liu, Lianshuang Zhang, Wei Zhao, Wendan Yuan, Qianqian Luo, Hao Wu, Xiying Luan, Hongqin Zhang
BACKGROUND: Human placenta-derived mesenchymal stem cell (hPMSC) transplantation has been demonstrated to be an effective way of recovering ovarian function in mice with autoimmune induced premature ovarian failure (POF). But the exact mechanism remains unclear. The goal of the present study is to investigate the role of immune factors (T-helper 17 (Th17), cytotoxic T (Tc17) and regulatory T (Treg) cells) in the recovery of ovarian function and whether the phosphatidylinositol 3-kinase (PI3K)/Akt signal pathway is involved in the regulation...
February 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29433563/therapeutic-effect-of-human-umbilical-cord-derived-mesenchymal-stem-cells-on-injured-rat-endometrium-during-its-chronic-phase
#3
Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma, Hong-Fei Xia
BACKGROUND: Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effective in repairing the damaged endometrium. However, the possibility of using umbilical cord-derived MSCs (UC-MSCs) to treat endometrial injury is rarely reported. METHODS: Ethanol (95%) was injected into rat uterus to establish a model of endometrial injury...
February 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29433579/the-role-of-fibrinolysis-inhibition-in-engineered-vascular-networks-derived-from-endothelial-cells-and-adipose-derived-stem-cells
#4
Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl, Wolfgang Holnthoner
BACKGROUND: Co-cultures of endothelial cells with mesenchymal stem cells currently represent one of the most promising approaches in providing oxygen and nutrient supply for microvascular tissue engineering. Still, to translate this model into clinics several in vitro parameters including growth medium and scaffold degradation need to be fine-tuned. METHODS: We recently described the co-culture of adipose-derived stem cells with endothelial cells in fibrin, resulting in capillary formation in vitro as well as their perfusion in vivo...
February 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29433559/cxcr7-participates-in-cxcl12-mediated-migration-and-homing-of-leukemic-and-normal-hematopoietic-cells
#5
LETTER
Rita de Cassia Carvalho Melo, Karla Priscila Viera Ferro, Adriana da Silva Santos Duarte, Sara Teresinha Olalla Saad
CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed that CXCR7 participates in normal CD34+ and U937 cell migration and prevents downregulation of CXCR4 by CXCL12 stimulation. In addition, CXCR7 contributes to homing of acute myeloid leukemia and normal progenitor cells to the bone marrow and spleen of NOD/SCID mice. In summary, this study shows an essential role of CXCR7, together with CXCR4, in the control of normal and malignant hematopoietic cell migration and homing induced by CXCL12...
February 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29426367/pip5k1%C3%AE-promotes-myogenic-differentiation-via-akt-activation-and-calcium-release
#6
Xiaofan Chen, Jun Wan, Bo Yu, Yarui Diao, Wei Zhang
BACKGROUND: Skeletal muscle satellite cell-derived myoblasts are mainly responsible for postnatal muscle growth and injury-induced regeneration. Many intracellular signaling pathways are essential for myogenic differentiation, while a number of kinases are involved in this modulation process. Type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI) was identified as one of the key kinases involved in myogenic differentiation, but the underlying molecular mechanism is still unclear. METHODS: PIP5K1α was quantified by quantitative reverse transcriptase PCR and western blot assay...
February 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29415771/bibliometric-analysis-of-global-scientific-activity-on-umbilical-cord-mesenchymal-stem-cells-a-swiftly-expanding-and-shifting-focus
#7
REVIEW
Jian Zhao, Guanyu Yu, Mengxi Cai, Xiao Lei, Yanyong Yang, Qijin Wang, Xiao Zhai
Several studies have focused on umbilical cord-derived mesenchymal stem cells (UC-MSCs) due to their potential therapeutic effects in a cluster of diseases. However, there has been no bibliometric analysis evaluating the evolution in UC-MSC research. Therefore, this study aimed to assess scientific activity regarding UC-MSC research. Publications on UC-MSCs were retrieved from the Science Citation Index-Expanded (SCI-E) of the Web of Science (WoS) from 1975 to 2017. Statistical analyses were performed using Excel, GraphPad Prism 5, and VOSviewer software...
February 7, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29409540/mesenchymal-stromal-cell-derived-exosome-rich-fractionated-secretome-confers-a-hepatoprotective-effect-in-liver-injury
#8
Apeksha Damania, Deepika Jaiman, Arun Kumar Teotia, Ashok Kumar
BACKGROUND: Mesenchymal stromal cells (MSCs) are an attractive therapeutic agent in regenerative medicine. Recently, there has been a paradigm shift from differentiation of MSCs to their paracrine effects at the injury site. Several reports elucidate the role of trophic factors secreted by MSCs toward the repair of injured tissues. We hypothesize that fractionating the MSC secretome will enrich exosomes containing soluble bioactive molecules, improving its therapeutic potential for liver failure...
February 6, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29402326/treatment-of-gingival-defects-with-gingival-mesenchymal-stem-cells-derived-from-human-fetal-gingival-tissue-in-a-rat-model
#9
Jing Li, Shi-Qing Xu, Kai Zhang, Wen-Jian Zhang, Hong-Lin Liu, Zhen Xu, Hong Li, Jin-Ning Lou, Li-Hong Ge, Bao-Hua Xu
BACKGROUND: The study aimed to evaluate the efficacy and safety of gingival mesenchymal stem cells (GMSCs) from human fetal gingival tissue used for treating gingival defects in a rat model. METHODS: GMSCs were isolated from human fetal gingival tissue and identified by flow cytometry for nestin, Oct4, vimentin, NANOG, CD105, and CD90. The immunogenicity of GMSCs was analyzed by mixed lymphocyte reactions; the tumorigenicity of GMSCs was evaluated by xenotransplanting into nude mice...
February 5, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29402311/hepatic-stem-cells-with-self-renewal-and-liver-repopulation-potential-are-harbored-in-cdcp1-positive-subpopulations-of-human-fetal-liver-cells
#10
Ran-Ran Zhang, Yun-Wen Zheng, Bin Li, Yun-Zhong Nie, Yasuharu Ueno, Tomonori Tsuchida, Hideki Taniguchi
BACKGROUND: Mature human hepatocytes are critical in preclinical research and therapy for liver disease, but are difficult to manipulate and expand in vitro. Hepatic stem cells (HpSCs) may be an alternative source of functional hepatocytes for cell therapy and disease modeling. Since these cells play an import role in regenerative medicine, the precise characterization that determines specific markers used to isolate these cells as well as whether they contribute to liver regeneration still remain to be shown...
February 5, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29402309/embryonic-stem-cell-derived-cardiomyocytes-for-the-treatment-of-doxorubicin-induced-cardiomyopathy
#11
Danúbia Silva Dos Santos, Guilherme Visconde Brasil, Isalira Peroba Rezende Ramos, Fernanda Cristina Paccola Mesquita, Tais Hanae Kasai-Brunswick, Michelle Lopes Araújo Christie, Gustavo Monnerat Cahli, Raiana Andrade Quintanilha Barbosa, Sandro Torrentes da Cunha, Jonathas Xavier Pereira, Emiliano Medei, Antonio Carlos Campos de Carvalho, Adriana Bastos Carvalho, Regina Coeli Dos Santos Goldenberg
BACKGROUND: Doxorubicin (Dox) is a chemotherapy drug with limited application due to cardiotoxicity that may progress to heart failure. This study aims to evaluate the role of cardiomyocytes derived from mouse embryonic stem cells (CM-mESCs) in the treatment of Dox-induced cardiomyopathy (DIC) in mice. METHODS: The mouse embryonic stem cell (mESC) line E14TG2A was characterized by karyotype analysis, gene expression using RT-PCR and immunofluorescence. Cells were transduced with luciferase 2 and submitted to cardiac differentiation...
February 5, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29402304/comprehensive-characterization-of-chorionic-villi-derived-mesenchymal-stromal-cells-from-human-placenta
#12
Mónica S Ventura Ferreira, Michaela Bienert, Katrin Müller, Björn Rath, Tamme Goecke, Christian Opländer, Till Braunschweig, Petra Mela, Tim H Brümmendorf, Fabian Beier, Sabine Neuss
BACKGROUND: Studies in which mesenchymal stromal cells (MSC) from the placenta are compared with multiple MSC types from other sources are rare. The chorionic plate of the human placenta is mainly composed of fetal blood vessels embedded in fetal stroma tissue, lined by trophoblastic cells and organized into chorionic villi (CV) structures. METHODS: We comprehensively characterized human MSC collected from postnatal human chorionic villi of placenta (CV-MSC) by analyzing their growth and proliferation potential, differentiation, immunophenotype, extracellular matrix production, telomere length, aging phenotype, and plasticity...
February 5, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29394956/establishment-of-xenogeneic-serum-free-culture-methods-for-handling-human-dental-pulp-stem-cells-using-clinically-oriented-in-vitro-and-in-vivo-conditions
#13
Mai Mochizuki, Taka Nakahara
BACKGROUND: Currently, ex-vivo handling of stem cells, including transport after harvest and therapeutic preparation, is generally done in culture media containing fetal bovine serum (FBS), which promotes cell attachment, proliferation, and differentiation. However, because of safety concerns associated with the use of FBS, including potential transmission of zoonotic agents and transplant rejection because of the incorporation of foreign proteins into the stem cells, there is a need for xenogeneic serum-free culture media for clinical handling of stem cells...
February 3, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29394953/bcn057-induces-intestinal-stem-cell-repair-and-mitigates-radiation-induced-intestinal-injury
#14
Payel Bhanja, Andrew Norris, Pooja Gupta-Saraf, Andrew Hoover, Subhrajit Saha
BACKGROUND: Radiation-induced gastrointestinal syndrome (RIGS) results from the acute loss of intestinal stem cells (ISC), impaired epithelial regeneration, and subsequent loss of the mucosal barrier, resulting in electrolyte imbalance, diarrhea, weight loss, sepsis, and mortality. The high radiosensitivity of the intestinal epithelium limits effective radiotherapy against abdominal malignancies and limits the survival of victims of nuclear accidents or terrorism. Currently, there is no approved therapy to mitigate radiation toxicity in the intestine...
February 2, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29391049/bone-regeneration-by-human-dental-pulp-stem-cells-using-a-helioxanthin-derivative-and-cell-sheet-technology
#15
Yasuyuki Fujii, Yoko Kawase-Koga, Hironori Hojo, Fumiko Yano, Marika Sato, Ung-Il Chung, Shinsuke Ohba, Daichi Chikazu
BACKGROUND: Human dental pulp stem cells (DPSCs), which have the ability to differentiate into multiple lineages, were recently identified. DPSCs can be collected readily from extracted teeth and are now considered to be a type of mesenchymal stem cell with higher clonogenic and proliferative potential than bone marrow stem cells (BMSCs). Meanwhile, the treatment of severe bone defects, such as fractures, cancers, and congenital abnormalities, remains a great challenge, and novel bone regenerative techniques are highly anticipated...
February 1, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29386068/effects-of-hpmscs-on-granulosa-cell-apoptosis-and-amh-expression-and-their-role-in-the-restoration-of-ovary-function-in-premature-ovarian-failure-mice
#16
Hongqin Zhang, Qianqian Luo, Xueyan Lu, Na Yin, Dongli Zhou, Lianshuang Zhang, Wei Zhao, Dong Wang, Pengchao Du, Yun Hou, Yan Zhang, Wendan Yuan
BACKGROUND: This study was performed to determine the effects of human placenta mesenchymal stem cell (hPMSC) transplantation on granulosa cell apoptosis and anti-Müllerian hormone (AMH) and follicle-stimulating hormone receptor (FSHR) expression in autoimmune drug-induced premature ovarian failure (POF) mice. The aim of this research is to investigate the mechanisms of hPMSCs on ovarian reserve capacity. METHODS: The POF mice model was established by injection of zona pellucida 3 peptide (pZP3)...
January 31, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29386057/delivery-of-vegfa-in-bone-marrow-stromal-cells-seeded-in-copolymer-scaffold-enhances-angiogenesis-but-is-inadequate-for-osteogenesis-as-compared-with-the-dual-delivery-of-vegfa-and-bmp2-in-a-subcutaneous-mouse-model
#17
Sunita Sharma, Dipak Sapkota, Ying Xue, Saroj Rajthala, Mohammed A Yassin, Anna Finne-Wistrand, Kamal Mustafa
BACKGROUND: In bone tissue engineering (BTE), extensive research into vascular endothelial growth factor A (VEGFA)-mediated angiogenesis has yielded inconsistent results. The aim of this study was to investigate the influence on angio- and osteogenesis of adenoviral-mediated delivery of VEGFA alone or in combination with bone morphogenetic protein 2 (BMP2) in bone marrow stromal cells (BMSC) seeded onto a recently developed poly(LLA-co-CL) scaffold. METHODS: Human BMSC were engineered to express VEGFA alone or in combination with BMP2 and seeded onto poly(LLA-co-CL) scaffolds...
January 31, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29386050/curcumin-mediated-bone-marrow-mesenchymal-stem-cell-sheets-create-a-favorable-immune-microenvironment-for-adult-full-thickness-cutaneous-wound-healing
#18
Zhi Yang, Chengmin He, Jinyang He, Jing Chu, Hanping Liu, Xiaoyuan Deng
BACKGROUND: Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-mediated tissue regeneration driven by biomaterial offers an attractive regenerative strategy for damaged tissue repair. METHODS: In this research, we investigated a specific bone marrow-derived mesenchymal stem cell (BMSC) sheet that was induced by the Traditional Chinese Medicine curcumin (CS-C) and its immunomodulatory effects on wound repair...
January 31, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29386049/an-open-label-proof-of-concept-study-of-intrathecal-autologous-bone-marrow-mononuclear-cell-transplantation-in-intellectual-disability
#19
Alok Sharma, Hemangi Sane, Nandini Gokulchandran, Suhasini Pai, Pooja Kulkarni, Vaishali Ganwir, Maitree Maheshwari, Ridhima Sharma, Meenakshi Raichur, Samson Nivins, Prerna Badhe
BACKGROUND: The underlying pathophysiology in intellectual disability (ID) involves abnormalities in dendritic branching and connectivity of the neuronal network. This limits the ability of the brain to process information. Conceptually, cellular therapy through its neurorestorative and neuroregenerative properties can counteract these pathogenetic mechanisms and improve neuronal connectivity. This improved networking should exhibit as clinical efficacy in patients with ID. METHODS: To assess the safety and efficacy of cellular therapy in patients with ID, we conducted an open-label proof-of-concept study from October 2011 to December 2015...
January 31, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29386045/mesenchymal-stem-cell-based-therapy-for-radiation-induced-lung-injury
#20
REVIEW
Tiankai Xu, Yuyu Zhang, Pengyu Chang, Shouliang Gong, Lihong Shao, Lihua Dong
Since radiotherapy is widely used in managing thoracic tumors, physicians have begun to realize that radiation-induced lung injury (RILI) seriously limits the effects of radiotherapy. Unfortunately, there are still no effective methods for controlling RILI. Over the last few decades numerous studies have reported the beneficial effects of mesenchymal stem cells (MSCs) on tissue repair and regeneration. MSCs can not only differentiate into lung alveolar epithelial cells and secrete anti-inflammatory factors, but they also deliver some vehicles for gene therapy in repairing the injured lung, which provides new ideas for managing RILI...
January 31, 2018: Stem Cell Research & Therapy
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