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Journal of Cancer Science & Therapy

Jacqueline J Stevens, Barbara Graham, Erika Dugo, Bezawit Berhaneselassie-Sumner, Kenneth Ndebele, Paul B Tchounwou
BACKGROUND: Arsenic trioxide (ATO) is highly effective in the treatment of patients with acute promyelocytic leukemia (APL). It is a chemotherapeutic agent that has been shown to induce apoptosis in several tumor cell lines. However, research into its effects on colon carcinoma cells is still very limited. We previously reported that ATO is cytotoxic and causes DNA damage in HT-29 human colorectal adenocarcinoma cells. In the present study, we further evaluated its effect on oxidative stress (OS), and examined its apoptotic mechanisms of action on HT-29 cells...
January 2017: Journal of Cancer Science & Therapy
Adarsh Shankar, Meenu Jain, Mei Jing Lim, Kartik Angara, Peng Zeng, Syed A Arbab, Asm Iskander, Roxan Ara, Ali S Arbab, Bhagelu R Achyut
OBJECTIVE: Anti-angiogenic therapies (AATs), targeting VEGF-VEGFR pathways, are being used as an adjuvant to normalize glioblastoma (GBM) vasculature. Unexpectedly, clinical trials have witnessed transient therapeutic effect followed by aggressive tumor recurrence. In pre-clinical studies, targeting VEGFR2 with vatalanib, increased GBM growth under hypoxic microenvironment. There is limited understanding of these unanticipated results. Here, we investigated tumor cell associated phenotypes in response to VEGFR2 blockade...
2016: Journal of Cancer Science & Therapy
Alice M Walker, Jacqueline J Stevens, Kenneth Ndebele, Paul B Tchounwou
BACKGROUND: Lung cancer is one of the most lethal and common cancers in the world, causing up to 3 million deaths annually. The chemotherapeutic drugs that have been used in treating lung cancer include cisplatin-pemetrexed, cisplastin-gencitabinoe, carboplatin-paclitaxel and crizotinib. Arsenic trioxide (ATO) has been used in the treatment of acute promyelocytic leukemia. However, its effects on lung cancer are not known. We hypothesize that ATO may also have a bioactivity against lung cancer, and its mechanisms of action may involve apoptosis, DNA damage and changes in stress-related proteins in lung cancer cells...
January 2016: Journal of Cancer Science & Therapy
Paul J Akhenblit, Mark D Pagel
Cancer cells employ a deregulated cellular metabolism to leverage survival and growth advantages. The unique tumor energy metabolism presents itself as a promising target for chemotherapy. A pool of tumor energy metabolism targeting agents has been developed after several decades of efforts. This review will cover glucose and fatty acid metabolism, PI3K/AKT/mTOR, HIF-1 and glutamine pathways in tumor energy metabolism, and how they are being exploited for treatments and therapies by promising pre-clinical or clinical drugs being developed or investigated...
2016: Journal of Cancer Science & Therapy
Vijay Singh, Damodar Gupta, Alexandru Almasan
Rituximab has been revolutionized and validated CD20 targeting monoclonal antibody. Although, it is widely used for lymphoma therapy and many patients have been benefited. However significant numbers of patients are refractory or developed resistance to current therapies due to low level of CD20 expression and/or availability on cells surface. Thus development of novel anti-CD20 mAbs with great cell killing ability and enhance CD20 levels on cell surface can potentially exploit lymphoma therapy. In this scenario, we are summarizing the recently developed mAbs against CD20 and compounds that have ability to induce CD20 expression at significant level...
November 2015: Journal of Cancer Science & Therapy
Richard Licheng Wu, Shadan Ali, Fazlul H Sarkar, Rafic Beydoun
OBJECTIVE: Mucinous cystadenocarcinoma of appendix is a rare entity. Differentiating mucinous cystadenocarcinoma from mucinous cystadenoma is very challenging and depends on establishing the presence of malignant cells in the appendix wall. The invasion may be very difficult to assess in some cases, especially in early stages of the disease, which could have devastating prognostic effects on patients. Therefore, it is necessary to develop an ancillary test that can differentiate the mucinous cystadenocarcinoma from mucinous cystadenoma...
November 2015: Journal of Cancer Science & Therapy
Raagini Suresh, Seema Sethi, Shadan Ali, Tamar Giorgadze, Fazlul H Sarkar
OBJECTIVE: MicroRNAs (miRNAs) are known to play important roles in the diagnosis and prognosis of papillary thyroid cancer (PTC), and they are useful in developing targeted therapies. However, there have been no studies on the existence of racial differences in miRNAs expression that could explain differential overall survival of PTC patients. Expression analysis of miRNAs in major racial groups would be important for optimizing personalized treatment strategies. In the current study, we assessed the differential expression of 8 miRNAs between normal and tumor tissues, and also assessed racial differences between African American (AA) and Caucasian American (CA)...
May 2015: Journal of Cancer Science & Therapy
Jason B Garrison, Chunmin Ge, Lixiao Che, Derek A Pullum, Guang Peng, Sohaib Khan, Nira Ben-Jonathan, Jiang Wang, Chunying Du
BACKGROUND AND OBJECTIVES: Management of patients with breast cancer often fails because of inherent or acquired resistance to chemotherapy. BRUCE (BIR repeat containing ubiquitin-conjugating enzyme) is a member of the inhibitor of apoptosis protein (IAP) family. It has various cellular functions including suppression of apoptosis and promotion of cytokinesis. Furthermore, it pays a critical role in promotion of DNA damage repair and preservation of genome stability, a new function recently reported by our group...
April 2015: Journal of Cancer Science & Therapy
Hirendra Nath Banerjee, Arnold Banerji, Arunendra Nath Banerjee, Eilena Riddick, Jenae Petis, Shavonda Evans, Megha Patel, Carl Parson, Valerie Smith, E Gwebu, Sarah Voisin
To explore the effectiveness of Raman spectra to diagnose brain cancer glioblastoma multiforme (GBM), we investigated the Raman spectra of single cell from four different GBM cell lines developed from four different patients and analyzed the spectra. The Raman spectra of brain cancer (GBM) cells were similar in all these cell lines. The results indicate that Raman spectra can offer the experimental basis for the cancer diagnosis and treatment.
February 3, 2015: Journal of Cancer Science & Therapy
Carissa R Moore, Shanique Ke Edwards, Ping Xie
B cell neoplasms comprise >50% of blood cancers. However, many types of B cell malignancies remain incurable. Identification and validation of novel genetic risk factors and oncogenic signaling pathways are imperative for the development of new therapeutic strategies. We and others recently identified TRAF3, a cytoplasmic adaptor protein, as a novel tumor suppressor in B lymphocytes. We found that TRAF3 inactivation results in prolonged survival of mature B cells, which eventually leads to spontaneous development of B lymphomas in mice...
February 2015: Journal of Cancer Science & Therapy
Richard Licheng Wu, Shadan Ali, Sudeshna Bandyopadhyay, Baraa Alosh, Kinda Hayek, Mhd Fayez Daaboul, Ira Winer, Fazlul H Sarkar, Rouba Ali-Fehmi
OBJECTIVE: There is an increased risk of developing ovarian cancer (OC) in patients with endometriosis. Hence, development of new biomarkers may provide a positive clinical outcome for early detection. MicroRNAs (miRNAs) are small non-coding RNAs that play an important role in biological and pathological process and are currently used as diagnostic and prognostic markers in various cancers. In the current study, we assessed the differential expression of miRNAs from 19 paired ovarian cancer and its associated endometriosis tissue samples...
2015: Journal of Cancer Science & Therapy
Guannan Zhao, Yuqi Guo, Zixuan Chen, Yinan Wang, Chuanhe Yang, Andrew Dudas, Ziyun Du, Wen Liu, Yanan Zou, Erzsebet Szabo, Sue-Chin Lee, Michelle Sims, Weiwang Gu, Todd Tillmanns, Lawrence M Pfeffer, Gabor Tigyi, Junming Yue
OBJECTIVE: Ovarian cancer is a gynecological malignancy that has a high mortality rate in women due to metastatic progression and recurrence. miRNAs are small, endogenous, noncoding RNAs that function as tumor suppressors or oncogenes in various human cancers by selectively suppressing the expression of target genes. The objective of this study is to investigate the role of miR-203 in ovarian cancer. METHODS: miR-203 was expressed in ovarian cancer SKOV3 and OVCAR3 cells using lentiviral vector and cell proliferation, migration, invasion were examined using MTT, transwell and Matrigel assays, respectively...
2015: Journal of Cancer Science & Therapy
Shadan Ali, Hala Dubaybo, Randall E Brand, Fazlul H Sarkar
OBJECTIVE: Pancreatic cancer (PC) is a lethal disease with disappointing results from current treatment modalities, suggesting that novel therapeutic strategies are urgently needed. Since microRNAs (miRNAs) are important player in biology, the clinical utility of miRNAs for designing novel therapeutics is an active area of research. The objective of the present study was to examine differentially expressed miRNAs between normal and tumor tissues, and in plasma samples obtained from PC patients, chronic pancreatitis (CP) patients and healthy subjects (HC)...
2015: Journal of Cancer Science & Therapy
Julie K Jang, John Chretin, David Bruyette, Peisheng Hu, Alan L Epstein
OBJECTIVES: LEC chemokine promotes TH1 responses and recruits immune cells to inflammatory sites. By linking LEC to an antibody targeting tumor necrosis, LEC/chTNT-3 can be used for the immunotherapeutic treatment of tumors. The primary objective of this study was to determine the safety profile of LEC/chTNT-3 and toceranib phosphate (Palladia(®)) combination therapy in dogs with spontaneous malignancies. Secondary purpose was to determine objective responses to treatment. METHODS: Twenty-three dogs with cancer were enrolled, covering nine different malignancies...
2015: Journal of Cancer Science & Therapy
Chandi C Mandal, Md Mizanur Rahman
Substantial data from cell culture and animal studies evidence the preventive effect of statins, cholesterol lowering-drugs, in regulation of cancer cell proliferation and metastasis. Various clinical studies also support this correlation between use of statin and the reduction of cancer incidence. However, in some cases, statins have failed to decrease the risk of cancer. Since, instead of serum cholesterol, intracellular cholesterol may play a crucial role in the regulation of tumorigenesis and metastasis...
December 20, 2014: Journal of Cancer Science & Therapy
Mi-Heon Lee, Puja Kachroo, Paul C Pagano, Jane Yanagawa, Gerald Wang, Tonya C Walser, Kostyantyn Krysan, Sherven Sharma, Maie St John, Steven M Dubinett, Jay M Lee
BACKGROUND: The cyclooxygenase 2 (COX-2) pathway has been implicated in the molecular pathogenesis of many malignancies, including lung cancer. Apricoxib, a selective COX-2 inhibitor, has been described to inhibit epithelial-mesenchymal transition (EMT) in human malignancies. The mechanism by which apricoxib may alter the tumor microenvironment by affecting EMT through other important signaling pathways is poorly defined. IL-27 has been shown to have anti-tumor activity and our recent study showed that IL-27 inhibited EMT through a STAT1 dominant pathway...
November 2014: Journal of Cancer Science & Therapy
Amira Hosni-Ahmed, Michelle Sims, Terreia S Jones, Renukadevi Patil, Shivaputra Patil, Hossam Abdelsamed, Charles R Yates, Duane D Miller, Lawrence M Pfeffer
Glioma is a brain tumor that arises from glial cells or glial progenitor cells, and represents 80% of malignant brain tumor incidence in the United States. Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor malignancy with fewer than 8% of patients with GBM surviving for more than 3 years. Over the past 10 years, despite improvement in diagnosis and therapies for cancer, the survival rate for high-grade glioma patients remains dismal. The main focus of our research is to identify potent novel antiglioma small molecules...
September 25, 2014: Journal of Cancer Science & Therapy
Cornelia Meisenberg, Simon E Ward, Peter Schmid, Sherif F El-Khamisy
BACKGROUND AND OBJECTIVE: Small cell lung cancer (SCLC) is one of the most challenging tumors to treat due to high proliferation rate, early metastatic dissemination and rapid development of chemotherapy resistance. The current treatment protocols involve the use of topoisomerase 1 (TOP1) poisons such as irinotecan and topotecan in combination with platinum-based compounds. TOP1 poisons kill cancer cells by trapping TOP1 on DNA, generating lethal DNA double-strand breaks. A potential mechanism employed by cancer cells to resist killing by TOP1 poisons is to overexpress enzymes involved in the repair of TOP1-DNA breaks...
July 25, 2014: Journal of Cancer Science & Therapy
Samjot Singh Dhillon, Adrienne Groman, Alison Meagher, Todd Demmy, Graham W Warren, Sai Yendamuri
BACKGROUND: Published data suggest that diabetes influences survival of patients with lung cancer. The anti-cancer effect of metformin confounds this association. We sought to study the association of diabetes and metformin with survival in patients undergoing resection of stage I non-small cell lung cancer (NSCLC). METHODS: Pathologic stage I NSCLC patients undergoing anatomic resection from 2002 to 2011 were studied. A diagnosis of diabetes and diabetic medication use were identified through records...
July 2014: Journal of Cancer Science & Therapy
Madhavi Gangapuram, Suresh Eyunni, Kinfe K Redda
Breast cancer is leading cause of mortality among women, resulting in more than half a million deaths worldwide each year. Unfortunately, the recovery rate of advanced breast cancer by current available drug treatment is till unacceptably low. Chemotherapy is the main stay of cancer treatment and most of the drugs cause general toxicity to any non-proliferating cells, which can severely limit the therapeutic values of these drugs. Tetrahydroisoqinoline derivatives (THIQs) were identified as subtype selective estrogen receptor antagonists/agonists hence, potential therapeutic agents for breast cancer...
April 25, 2014: Journal of Cancer Science & Therapy
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