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https://www.readbyqxmd.com/read/29868144/serendipitous-discovery-of-factor-vii-deficiency-and-the-ensuing-dilemma
#1
Jayadev M Umakanthan, Prajwal Dhakal, Krishna Gundabolu, Scott A Koepsell, Muhamed Baljevic
Congenital factor VII deficiency is a challenging disorder to manage, as it is associated with varied genotypes that do not clinically correlate with a bleeding phenotype. Individuals with severe factor VII deficiency (FVII: c <1%) might be asymptomatic, while patients with moderate deficiency (FVII: c level >5%) may experience severe hemorrhages. In modern medicine, due to extensive routine pre-operative laboratory testing, clinically asymptomatic patients without any bleeding history might be incidentally discovered, raising clinical dilemmas...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868143/central-sleep-apnea-a-rare-cause-for-acute-respiratory-insufficiency-in-children-case-report
#2
Nicoleta Aurelia Popescu, Marcela Daniela Ionescu, Georgiana Balan, Simina Visan, Eliza Cinteza, Diana Stanescu, Ionut Gobej, Mihaela Balgradean
Central sleep apnea is characterized by frequent cessation of breathing during sleep, resulting in repetitive episodes of insufficient ventilation and abnormalities of acid-base balance. It may be primary or secondary, and it is uncommon in children, with limited data for this population. We present here the case of a five-year-old girl, known to have thoracolumbar myelomeningocele (for which she underwent a surgical procedure in infancy), secondary hydrocephalus (with a ventriculoperitoneal shunt) and flaccid paralysis, who was admitted in our hospital with prolonged fever syndrome, productive cough, severe dyspnea and perioral cyanosis...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868142/evolutionary-particularities-in-a-case-of-severe-pneumonia-in-children-case-report
#3
Marcela Daniela Ionescu, Nicoleta Aurelia Popescu, Georgiana Balan, Veronica Marcu, Augustina Enculescu, Lorena Vatra, Marcel Oancea, Mihaela Balgradean
Necrotizing pneumonia remains an uncommon complication of pneumonia in children, but its incidence is increasing. Pneumococcal infection is the predominant cause of severe necrotizing pneumonia in children, but methicillin resistant Staphylococcus aureus (MRSA) and Panton-Valentine leukocidin (PVL) staphylococcal infections are also important. We present the case of a four-year-old girl,with an unremarkable medical history, who was admitted in our hospital with a history of high fever, productive cough and tachypnea lasting for 10 days, progressive worsening despite empirical oral antibiotic...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868141/role-of-multidetector-computed-tomography-mdct-in-evaluation-of-gallbladder-malignancy-and-its-pathological-correlation-in-an-indian-rural-center
#4
Gunjan Jindal, Samita Singal, Birinder Nagi, Amit Mittal, Shallini Mittal, Rikki Singal
Objectives: Clinically or sonographically suspected gallbladder carcinoma was evaluated on multidetector computed tomography. Based on the spectrum of multidetector computed tomography findings, staging of gallbladder carcinoma was done. Multidetector computed tomography diagnosis was compared with pathological diagnosis. Material and methods: This is a prospective study carried out in 100 patients at a rural Indian center between May 2012 and June 2015. Multidetector computed tomography was performed in all the cases and the findings were observed...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868140/amoebic-colonic-perforation-presenting-as-peritonitis-in-emergency-incidence-and-outcome-our-experience
#5
Muzzafar Zaman, Kunal Chowdhary, Gurinder Kaur, Aliya Shah
Objectives: Amoebiasisis a common parasitic infection and fulminant amoebic colitis remains a very rare complication of this disease. The objective of the present study was to find the incidence and outcome of perforation peritonitis due to amoebic colitis in MMIMSR, Mullana, Ambala, India. Material and methods: 200 patients with perforation peritonitis were studied retrospectively, out of which 22 cases had colonic perforation, were selected over a period of five years, between 2012 to 2017, at MMIMSR Mullana...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868139/the-safety-and-efficacy-of-clipless-versus-conventional-laparoscopic-cholecystectomy-our-experience-in-an-indian-rural-center
#6
Rikki Singal, Abhishek Sharma, Muzzafar Zaman
Background: Laparoscopic cholecystectomy is one of the most common surgeries performed nowadays. There are lot of advances in closure of cystic duct and artery (clip ligation, suture ligation), but it remains an enigma regarding efficacy, safety and postoperative complications for using non-absorbable suture material or Liga clip for the operating surgeon in laparoscopic cholecystectomy. Objectives: Our study aimed to evaluate the efficacy, safety and complications of non-absorbable sutures ligation versus clips application in laparoscopic cholecystectomy, and to compare the operative time and cost effectiveness of the two surgical approaches in laparoscopic cholecystectomy...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868138/psychometric-properties-of-the-romanian-version-of-the-hospital-survey-on-patient-safety-culture-hsops
#7
Carmen Tereanu, Scott Alan Smith, Mugurel Stefan Ghelase, Giuseppe Sampietro, Adrian Molnar, Antoaneta Dragoescu, Florentina Ligia Furtunescu, Camelia Stanescu, Olguta Alice Gavrila, Anca Patrascu, Andreea Loredana Golli, Manuela Dragomir
Objective: To explore psychometrics of the Romanian version of the Hospital Survey on Patient Safety Culture (HSOPS) released by the US Agency for Healthcare Research and Quality in 2004. Material and methods: The original US survey with 12 composites and 42 items was translated (back translation method), pre-tested on a few staff and then minimally adjusted. A qualitative cross-sectional study was carried out in units from six hospitals in four Romanian regions, based on the census of medical and non-medical staff (n...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868137/treatment-effects-upon-prolactin-and-soluble-receptor-of-interleukin-2-in-psoriatic-patients
#8
Delia Botezatu, Mihaela Tovaru, Simona-Roxana Georgescu, Antoanela Curici, Calin Giurcaneanu
Background: Psoriasis vulgaris is a chronic inflammatory hyper-proliferative disease of the skin, scalp, nails, and joints. It has been hypothesized that prolactin (PRL) may modulate the skin immune system and be involved in the pathogenesis of psoriasis. Psoriasis exerts significant, negative impact on patients' quality of life. Relatively high rates of depression are reported in patients with psoriasis. Objectives: The aim of this work was to study the possible role of PRL in the pathogenesis of psoriasis and its correlation with the disease activity, clinically, molecular and emotional status of patients...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868136/prevalence-of-family-history-of-autoimmune-disorders-in-juvenile-systemic-lupus-erythematosus
#9
Parisa Ashournia, Payman Sadeghi, Nima Rezaei, Mohammad-Hassan Moradinejad, Vahid Ziaee
One of the causes of infants' hospitalizations is bronchiolitis, while different viral agents could be causative agents. As there is little information regarding the common agents of bronchiolitis in Iranian infants, we designed this study to determine which agents were responsible for hospitalization due to bronchiolitis among infants in an Iranian tertiary center. Two hundred and three infants with bronchiolitis who were hospitalized in Bahrami hospital were enrolled. Data regarding age, sex, duration of hospitalization, exposure to smoking, previous antibiotic usage and fever were collected for all enrolled cases...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868135/viral-aetiology-of-bronchiolitis-in-hospitalised-children-in-a-tertiary-center-in-tehran
#10
Ali Akbar Rahbarimanesh, Anahita Izadi, Mahsa Ghajarzadeh
One of the causes of infants' hospitalizations is bronchiolitis, while different viral agents could be causative agents. As there is little information regarding the common agents of bronchiolitis in Iranian infants, we designed this study to determine which agents were responsible for hospitalization due to bronchiolitis among infants in an Iranian tertiary center. Two hundred and three infants with bronchiolitis who were hospitalized in Bahrami hospital were enrolled. Data regarding age, sex, duration of hospitalization, exposure to smoking, previous antibiotic usage and fever were collected for all enrolled cases...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868134/tumor-necrosis-factor-alpha-gene-expression-in-pbmcs-of-iranian-azeri-turkish-patients-with-premature-coronary-artery-disease-age-50-years
#11
Mahssa Hassan-Nejhad, Morteza Bagheri, Kamal Khadem-Vatani, Mir Hossein Seyed Mohammad Zad, Isa Abdi Rad, Behzad Rahimi, Ali Rostamzadeh, Amir Rahimlou
Background: Coronary artery disease is the leading cause of disability and mortality in Iran and worldwide. Tumor necrosis factor-alpha is a pro-inflammatory cytokine that plays a key role in inflammatory cascades and atherosclerosis. It regulates cytokine networks and adhesion molecule expression, and activates several signal transduction pathways, being also known as transducer of cardiovascular diseases, especially premature coronary artery disease. Objective: The aim of the present study was to investigate tumor necrosis factor-alpha gene expression in Iranian Azeri Turkish patients with premature coronary artery disease (age ≤50 years)...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868133/ischemic-hepatitis-intercorrelated-pathology
#12
Andrea Olivia Ciobanu, Leonida Gherasim
Ischemic hepatitis is an important, yet underdiagnosed pathological condition seen in either cardiology or hepatology clinics or intensive care units. The main causes are severe heart failure, circulatory and septic shock. Close monitoring of biological tests (AST, ALT, LDH) together with hemodynamic parameters (blood pressure, cardiac output and central venous pressure) allow for rapid and accurate diagnosis. Correction of hemodynamic parameters, hypoxemia, hepatic and/or renal dysfunction leads to a more favorable outcome of these patients...
March 2018: Mædica
https://www.readbyqxmd.com/read/29868132/we-need-cars-more-and-more
#13
EDITORIAL
Mircea Cinteza
No abstract text is available yet for this article.
March 2018: Mædica
https://www.readbyqxmd.com/read/29610596/catecholaminergic-polymorphic-ventricular-tachycardia-looking-to-the-future
#14
Andreea Elena Velcea, Calin Siliste, Dragos Vinereanu
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inheritable cardiac disorder, characterized by polymorphic ventricular tachycardia (PVT) or bidirectional ventricular tachycardia, triggered by adrenergic stress, and manifested most frequently as syncope or sudden cardiac death. The disease has a heterogeneous genetic basis, with mutations in the genes encoding the ryanodine and calsequestrin channels accounting for the majority of cases. The diagnosis of CPVT is established in individuals with polymorphic ventricular premature beats, PVT or bidirectional ventricular tachycardia documented during exercise or adrenergic stress, who have a structurally normal heart and normal resting ECG...
December 2017: Mædica
https://www.readbyqxmd.com/read/29610595/the-basic-steps-of-evolution-of-brain-surgery
#15
Alexandrina Nikova, Theodossios Birbilis
Objective and conclusion: Neurosurgery is probably the most constantly developing specialty of all times. Its dimension is enormous and its history, Ancient. The evolution of neurosurgery from the Mayan and Egyptian periods to the Renaissance and the 21st century was the result of many physicians and patients whose experiences lead to the revolution of modernization. Today, the field of neurosurgery is continuously expanding, aiming to introduce knowledge and technologies that could provide a new futuristic wave of medicine...
December 2017: Mædica
https://www.readbyqxmd.com/read/29610594/tyrosine-kinase-inhibitors-treatment-in-advanced-malignant-melanoma
#16
Andrei Popescu, Rodica Maricela Anghel
Objective: To put in perspective recent advances in the treatment of malignant melanoma with novel tyrosine-kinase inhibitors. Methods: We reviewed the largest trials that support the treatment with tyrosine-kinase inhibitors (TKIs) in cutaneous malignant melanoma, the base of the current guideline recommendations. Conclusions: Mitogen-activated protein-kinase (MAPK) pathway inhibition via modern TKIs is a major breakthrough in the treatment of melanoma, with a very high benefit for patients with disease harboring BRAF-gene mutations, in terms of rates of response and survival...
December 2017: Mædica
https://www.readbyqxmd.com/read/29610593/immunological-evaluation-of-surgical-stress-in-liver-resections
#17
Alexandru Munteanu, Gabriel Samasca, Iulia Lupan, Cornel Iancu
Surgery has its origins in caring for patients suffering from injury or infection. In the last decade, a huge amount of published data has been describing a wide range of conditions resulting from trauma or infection, from minor, local reactions to a surgical operation and leading to a systemic stress response, systemic inflammatory response and finally to multiple organ failure. Our aim was to highlight the main immunological aspects of liver resections. There are many types of liver resections, ranging from small, isolated resections for benign diseases (e...
December 2017: Mædica
https://www.readbyqxmd.com/read/29610592/predominant-upper-limb-chronic-demyelinating-polyneuropathy-associated-with-hbv-infection
#18
Ioan-Cristian Lupescu, Adriana Octaviana Dulamea
Chronic inflammatory demyelinating polyneuropathy is an acquired, presumably immune-mediated peripheral neuropathy, characterized by symmetric sensory-motor involvement. Although most often idiopathic, it has been described in association with several disorders, sometimes improving under treatment. We present the case of a 57-year-old male who was admitted to hospital for paresthesias and muscle weakness affecting both upper limbs, initially only the hands, but with worsening and ascending progression during the last three years...
December 2017: Mædica
https://www.readbyqxmd.com/read/29610591/does-phantom-tumor-really-exist
#19
Dan-Nicolae Tesloianu, Mihaela Chioarta, Dana Corduneanu, Andreea-Mihaela Ignat, Antoniu Octavian Petris, Anda Tesloianu
Localized interlobar effusion in congestive heart failure (known as phantom tumor or vanishing tumor of the lung) is an uncommon entity. We report a case of a 61-year-old man who presented to the Emergency Departament with a two week history of dyspnoea, palpitations, dry cough and intermitent anterior chest pain. A posteroanterior chest radiography showed a nodular mass in the medium third of the right hemithorax suggestive of a pulmonary tumor. With this supposition of diagnosis, the patient was admitted to the Pneumology Departament for further investigations...
December 2017: Mædica
https://www.readbyqxmd.com/read/29610590/effects-of-appropriate-nutrition-training-in-small-groups-on-laboratory-parameters-in-hemodialysis-patients-from-iran
#20
Nader Aghakhani, Seyyedeh Leila Hoseini, Kourosh Kamali, Davoud Vahabzadeh
Introduction: Adherence to appropriate nutrition and fluid intake is one of the essential parts of chronic renal failure treatment for achieving the desirable results among the patients with hemodialysis. Among various training methods, the "small groups' method", as an advanced method, can be performed by nurses in achieving desirable therapeutic results. The present study was aimed to investigate the effect of appropriate nutrition training in small groups on laboratory parameters in hemodialysis patients...
December 2017: Mædica
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