journal
https://read.qxmd.com/read/23935642/antimicrobial-peptides-versatile-biological-properties
#21
JOURNAL ARTICLE
Muthuirulan Pushpanathan, Paramasamy Gunasekaran, Jeyaprakash Rajendhran
Antimicrobial peptides are diverse group of biologically active molecules with multidimensional properties. In recent past, a wide variety of AMPs with diverse structures have been reported from different sources such as plants, animals, mammals, and microorganisms. The presence of unusual amino acids and structural motifs in AMPs confers unique structural properties to the peptide that attribute for their specific mode of action. The ability of these active AMPs to act as multifunctional effector molecules such as signalling molecule, immune modulators, mitogen, antitumor, and contraceptive agent makes it an interesting candidate to study every aspect of their structural and biological properties for prophylactic and therapeutic applications...
2013: International Journal of Peptides
https://read.qxmd.com/read/23878547/amyloid-beta-peptides-differentially-affect-hippocampal-theta-rhythms-in-vitro
#22
JOURNAL ARTICLE
Armando I Gutiérrez-Lerma, Benito Ordaz, Fernando Peña-Ortega
Soluble amyloid beta peptide (A β ) is responsible for the early cognitive dysfunction observed in Alzheimer's disease. Both cholinergically and glutamatergically induced hippocampal theta rhythms are related to learning and memory, spatial navigation, and spatial memory. However, these two types of theta rhythms are not identical; they are associated with different behaviors and can be differentially modulated by diverse experimental conditions. Therefore, in this study, we aimed to investigate whether or not application of soluble A β alters the two types of theta frequency oscillatory network activity generated in rat hippocampal slices by application of the cholinergic and glutamatergic agonists carbachol or DHPG, respectively...
2013: International Journal of Peptides
https://read.qxmd.com/read/23737806/nociceptin-signaling-involves-a-calcium-based-depolarization-in-tetrahymena-thermophila
#23
JOURNAL ARTICLE
Thomas Lampert, Cheryl Nugent, John Weston, Nathanael Braun, Heather Kuruvilla
Tetrahymena thermophila are free-living, ciliated eukaryotes. Their behavioral response to stimuli is well characterized and easily observable, since cells swim toward chemoattractants and avoid chemorepellents. Chemoattractant responses involve increased swim speed or a decreased change in swim direction, while chemorepellent signaling involves ciliary reversal, which causes the organism to jerk back and forth, swim in small circles, or spin in an attempt to get away from the repellent. Many food sources, such as proteins, are chemoattractants for these organisms, while a variety of compounds are repellents...
2013: International Journal of Peptides
https://read.qxmd.com/read/23606863/interaction-between-pirenzepine-and-ninjinto-a-traditional-japanese-herbal-medicine-on-the-plasma-gut-regulated-peptide-levels-in-humans
#24
JOURNAL ARTICLE
Yuhki Sato, Itoh Hiroki, Yosuke Suzuki, Ryosuke Tatsuta, Masaharu Takeyama
The Japanese herbal medicine (Kampo) Ninjinto has been used for the treatment of gastroenteritis, esogastritis, gastric atony, gastrectasis, vomiting, and anorexia. The pharmacological effects of Ninjinto on the gastrointestine are due to changes in the levels of gut-regulated peptide, such as motilin, somatostatin, calcitonin gene-related peptide (CGRP), substance P, and vasoactive intestinal polypeptide (VIP). The release of these peptides is controlled by acetylcholine (ACh) from the preganglionic fibers of the parasympathetic nerve...
2013: International Journal of Peptides
https://read.qxmd.com/read/23589717/significant-increase-in-salivary-substance-p-level-after-a-single-oral-dose-of-cevimeline-in-humans
#25
JOURNAL ARTICLE
Yosuke Suzuki, Hiroki Itoh, Kohei Amada, Ryota Yamamura, Yuhki Sato, Masaharu Takeyama
Cevimeline is a novel muscarinic acetylcholine receptor agonist currently being developed as a therapeutic agent for xerostomia. We examined the effects of cevimeline on salivary and plasma levels of substance-P- (SP-), calcitonin-gene-related-peptide- (CGRP-), and vasoactive-intestinal-polypeptide- (VIP-) like immunoreactive substances (ISs) in humans. An open-labeled crossover study was conducted on seven healthy volunteers. Saliva volume was measured, and saliva and venous blood samples were collected before and 30-240 min after a single oral dose of cevimeline or placebo...
2013: International Journal of Peptides
https://read.qxmd.com/read/23554820/antimicrobial-lactoferrin-peptides-the-hidden-players-in-the-protective-function-of-a-multifunctional-protein
#26
JOURNAL ARTICLE
Mau Sinha, Sanket Kaushik, Punit Kaur, Sujata Sharma, Tej P Singh
Lactoferrin is a multifunctional, iron-binding glycoprotein which displays a wide array of modes of action to execute its primary antimicrobial function. It contains various antimicrobial peptides which are released upon its hydrolysis by proteases. These peptides display a similarity with the antimicrobial cationic peptides found in nature. In the current scenario of increasing resistance to antibiotics, there is a need for the discovery of novel antimicrobial drugs. In this context, the structural and functional perspectives on some of the antimicrobial peptides found in N-lobe of lactoferrin have been reviewed...
2013: International Journal of Peptides
https://read.qxmd.com/read/23533449/%C3%AE-rgib-a-novel-antagonist-peptide-of-neuronal-acetylcholine-receptor-isolated-from-conus-regius-venom
#27
JOURNAL ARTICLE
Maria Cristina Vianna Braga, Arthur Andrade Nery, Henning Ulrich, Katsuhiro Konno, Juliana Mozer Sciani, Daniel Carvalho Pimenta
Conus venoms are rich sources of biologically active peptides that act specifically on ionic channels and metabotropic receptors present at the neuromuscular junction, efficiently paralyzing the prey. Each species of Conus may have 50 to 200 uncharacterized bioactive peptides with pharmacological interest. Conus regius is a vermivorous species that inhabits Northeastern Brazilian tropical waters. In this work, we characterized one peptide with activity on neuronal acetylcholine receptor (nAChR). Crude venom was purified by reverse-phase HPLC and selected fractions were screened and sequenced by mass spectrometry, MALDI-ToF, and ESI-Q-ToF, respectively...
2013: International Journal of Peptides
https://read.qxmd.com/read/23533448/phage-display-screening-for-tumor-necrosis-factor-%C3%AE-binding-peptides-detection-of-inflammation-in-a-mouse-model-of-hepatitis
#28
JOURNAL ARTICLE
Coralie Sclavons, Carmen Burtea, Sébastien Boutry, Sophie Laurent, Luce Vander Elst, Robert N Muller
TNF- α is one of the most abundant cytokines produced in many inflammatory and autoimmune conditions such as multiple sclerosis, chronic hepatitis C, or neurodegenerative diseases. These pathologies remain difficult to diagnose and consequently difficult to treat. The aim of this work is to offer a new diagnostic tool by seeking new molecular probes for medical imaging. The target-specific part of the probe consists here of heptameric peptides selected by the phage display technology for their affinity for TNF- α ...
2013: International Journal of Peptides
https://read.qxmd.com/read/23533447/systemic-ghrelin-administration-alters-serum-biomarkers-of-angiogenesis-in-diet-induced-obese-mice
#29
JOURNAL ARTICLE
M Khazaei, Z Tahergorabi
Introduction. Ghrelin is a gastrointestinal endocrine peptide that was initially identified as the endogenous ligand of growth hormone secretagogue receptor; however, recently, the cardiovascular effect of this peptide has been indicated. In this study, we investigated the effect of ghrelin administration on serum biomarkers of angiogenesis including leptin, nitric oxide (NO), vascular endothelial growth factor (VEGF), and its soluble receptor (VEGF receptor 1 or sFlt-1) in control- and diet-induced obese mice...
2013: International Journal of Peptides
https://read.qxmd.com/read/23509470/sequence-determination-of-a-novel-tripeptide-isolated-from-the-young-leaves-of-azadirachta-indica-a-juss
#30
JOURNAL ARTICLE
M Rajeswari Prabha, B Ramachandramurty
The neem tree has long been recognized for its unique properties, both against insects and in improving human health. Every part of the tree has been used as a traditional medicine for household remedy against various human ailments, from antiquity. Although the occurrence of various phytochemicals in neem has been studied, we have identified the presence of a novel tripeptide in the young leaves of neem using a simple and inexpensive paper chromatographic method, detected by Cu(II)-ninhydrin reagent. The peptide nature of the isolated compound is confirmed by spectral studies...
2013: International Journal of Peptides
https://read.qxmd.com/read/23476673/peptide-receptor-targeting-in-cancer-the-somatostatin-paradigm
#31
JOURNAL ARTICLE
Federica Barbieri, Adriana Bajetto, Alessandra Pattarozzi, Monica Gatti, Roberto Würth, Stefano Thellung, Alessandro Corsaro, Valentina Villa, Mario Nizzari, Tullio Florio
Peptide receptors involved in pathophysiological processes represent promising therapeutic targets. Neuropeptide somatostatin (SST) is produced by specialized cells in a large number of human organs and tissues. SST primarily acts as inhibitor of endocrine and exocrine secretion via the activation of five G-protein-coupled receptors, named sst1-5, while in central nervous system, SST acts as a neurotransmitter/neuromodulator, regulating locomotory and cognitive functions. Critical points of SST/SST receptor biology, such as signaling pathways of individual receptor subtypes, homo- and heterodimerization, trafficking, and cross-talk with growth factor receptors, have been extensively studied, although functions associated with several pathological conditions, including cancer, are still not completely unraveled...
2013: International Journal of Peptides
https://read.qxmd.com/read/23365585/peptide-modulated-activity-enhancement-of-acidic-protease-cathepsin-e-at-neutral-ph
#32
JOURNAL ARTICLE
Masayuki Komatsu, Madhu Biyani, Sunita Ghimire Gautam, Koichi Nishigaki
Enzymes are regulated by their activation and inhibition. Enzyme activators can often be effective tools for scientific and medical purposes, although they are more difficult to obtain than inhibitors. Here, using the paired peptide method, we report on protease-cathepsin-E-activating peptides that are obtained at neutral pH. These selected peptides also underwent molecular evolution, after which their cathepsin E activation capability improved. Thus, the activators we obtained could enhance cathepsin-E-induced cancer cell apoptosis, which indicated their potential as cancer drug precursors...
2012: International Journal of Peptides
https://read.qxmd.com/read/23346117/identification-and-characterization-of-a-novel-nontranslated-sequence-variant-of-the-human-intestinal-di-tripeptide-transporter-hpept1
#33
JOURNAL ARTICLE
Helle Bach Søndergaard, Carsten Uhd Nielsen, Birger Brodin
The human H(+)-coupled di-/tripeptide transporter (hPEPT1) mediates intestinal absorption of dietary di- and tripeptides, as well as several peptidomimetic drug compounds. The aim of the present study was to investigate the possible role of the hPEPT1 variant hPEPT1-RF in hPEPT1 regulation. However, the proposed hPEPT1-RF mRNA sequence could not be detected in Caco-2 cells or in human intestinal samples. Instead, a new sequence variant, hPEPT1-RFI, was found, which is almost identical to the proposed hPEPT1-RF, except for two nucleotide insertions and one deletion that resulted in a changed open reading frame as compared to hPEPT1-RF...
2012: International Journal of Peptides
https://read.qxmd.com/read/23316247/peptidomic-analysis-of-the-brain-and-corpora-cardiaca-corpora-allata-complex-in-the-bombyx-mori
#34
JOURNAL ARTICLE
Xiaoguang Liu, Xia Ning, Yan Zhang, Wenfeng Chen, Zhangwu Zhao, Qingwen Zhang
The silkworm, Bombyx mori, is an important economic insect for silk production. However, many of the mature peptides relevant to its various life stages remain unknown. Using RP-HPLC, MALDI-TOF MS, and previously identified peptides from B. mori and other insects in the transcriptome database, we created peptide profiles showing a total of 6 ion masses that could be assigned to peptides in eggs, including one previously unidentified peptide. A further 49 peptides were assigned to larval brains. 17 new mature peptides were identified in isolated masses...
2012: International Journal of Peptides
https://read.qxmd.com/read/23227057/synthesis-of-hemopressin-peptides-by-classical-solution-phase-fragment-condensation
#35
JOURNAL ARTICLE
P Anantha Reddy, Sean T Jones, Anita H Lewin, F Ivy Carroll
A fragment condensation solution phase assembly of the naturally occurring CB(1) inverse agonist nonapeptides, Pro-Val-Asn-Phe-Lys-Phe/Leu-Leu-Ser-His-OH (hemopressins), and two other homologues: N-terminal 2-amino acid (dipeptide) extended undecapeptide, Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH, and three-amino acid (tripeptide) extended dodecapeptide, Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH, both CB(1) agonists, is reported.
2012: International Journal of Peptides
https://read.qxmd.com/read/23118773/diet-induced-obesity-in-mice-overexpressing-neuropeptide-y-in-noradrenergic-neurons
#36
JOURNAL ARTICLE
Suvi T Ruohonen, Laura H Vähätalo, Eriika Savontaus
Neuropeptide Y (NPY) is a neurotransmitter associated with feeding and obesity. We have constructed an NPY transgenic mouse model (OE-NPY(DBH) mouse), where targeted overexpression leads to increased levels of NPY in noradrenergic and adrenergic neurons. We previously showed that these mice become obese on a normal chow. Now we aimed to study the effect of a Western-type diet in OE-NPY(DBH) and wildtype (WT) mice, and to compare the genotype differences in the development of obesity, insulin resistance, and diabetes...
2012: International Journal of Peptides
https://read.qxmd.com/read/23118772/large-scale-solid-phase-synthesis-of-peptide-drugs-use-of-commercial-anion-exchange-resin-as-quenching-agent-for-removal-of-iodine-during-disulphide-bond-formation
#37
JOURNAL ARTICLE
K M Bhaskara Reddy, Y Bharathi Kumari, Dokka Mallikharjunasarma, Kamana Bulliraju, Vanjivaka Sreelatha, Kuppanna Ananda
The S-acetamidomethyl (Acm) or trityl (Trt) protecting groups are widely used in the chemical synthesis of peptides that contain one or more disulfide bonds. Treatment of peptides containing S-Acm protecting group with iodine results in simultaneous removal of the sulfhydryl protecting group and disulfide formation. However, the excess iodine needs to be quenched or adsorbed as quickly as possible after completion of the disulfide bond formation in order to minimize side reactions that are often associated with the iodination step...
2012: International Journal of Peptides
https://read.qxmd.com/read/22927866/natural-peptides-with-potential-applications-in-drug-development-diagnosis-and-or-biotechnology
#38
JOURNAL ARTICLE
Mirian A F Hayashi, Frédéric Ducancel, Katsuhiro Konno
No abstract text is available yet for this article.
2012: International Journal of Peptides
https://read.qxmd.com/read/22811735/a-meta-analysis-of-the-therapeutic-effects-of-glucagon-like-peptide-1-agonist-in-heart-failure
#39
JOURNAL ARTICLE
Mohammed Munaf, Pierpaolo Pellicori, Victoria Allgar, Kenneth Wong
We conducted a meta-analysis of the existing literature of the therapeutic effects of using GLP-1 agonists to improve the metabolism of the failing heart. Animal studies showed significant improvement in markers of cardiac function, such as left ventricular ejection fraction (LVEF), with regular GLP-1 agonist infusions. In clinical trials, the potential effects of GLP-1 agonists in improving cardiac function were modest: LVEF improved by 4.4% compared to placebo (95% C.I 1.36-7.44, P = 0.005). However, BNP levels were not significantly altered by GLP-1 agonists in heart failure...
2012: International Journal of Peptides
https://read.qxmd.com/read/22754579/effects-of-endurance-and-resistance-training-on-calcitonin-gene-related-peptide-and-acetylcholine-receptor-at-slow-and-fast-twitch-skeletal-muscles-and-sciatic-nerve-in-male-wistar-rats
#40
JOURNAL ARTICLE
Abdolhossein Parnow, Reza Gharakhanlou, Zeinab Gorginkaraji, Somayeh Rajabi, Rasoul Eslami, Mahdi Hedayati, Reza Mahdian
The aim of this study was to investigate effects of endurance and resistance training (ET and RT) on CGRP and AChRs at slow and fast twitch muscles and sciatic nerve in rats. Twenty-five male rats were randomly assigned into three groups including sedentary (SED), endurance training (ET), and resistance training (RT). Animals of ET exercised for 12 weeks, five times/week, and 60 min/day at 30 m/min. Animals of RT were housed in metal cage with 2 m high wire-mesh tower, with water bottles set at the top...
2012: International Journal of Peptides
journal
journal
42923
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.