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International Journal of Peptides

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https://www.readbyqxmd.com/read/27504123/mystixin-7-peptide-protects-ionotropic-glutamatergic-mechanisms-against-glutamate-induced-excitotoxicity-in-vitro
#1
Anatoly A Mokrushin
Hyperactivation of the N-methyl-D-aspartic acid type glutamate receptors (NMDARs) causes glutamate excitotoxicity, a process potentially important for many neurological diseases. This study aims to investigate protective effects of the synthetic corticotrophin-releasing factor-like peptide, mystixin-7 (MTX), on model glutamate-induced excitotoxicity in vitro. The technique online monitoring of electrophysiological parameters (excitatory glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPAR) and NMDAR-dependent postsynaptic mechanisms) in the olfactory cortex slices was used...
2016: International Journal of Peptides
https://www.readbyqxmd.com/read/27123011/netrin-1-peptide-is-a-chemorepellent-in-tetrahymena-thermophila
#2
Heather Kuruvilla, Bradley Schmidt, Stephanie Song, Marian Bhajjan, Matthew Merical, Caleb Alley, Christopher Griffin, David Yoder, Josephine Hein, Daniel Kohl, Cambria Puffenberger, David Petroff, Elise Newcomer, Kortney Good, Graham Heston, Anna Hurtubise
Netrin-1 is a highly conserved, pleiotropic signaling molecule that can serve as a neuronal chemorepellent during vertebrate development. In vertebrates, chemorepellent signaling is mediated through the tyrosine kinase, src-1, and the tyrosine phosphatase, shp-2. Tetrahymena thermophila has been used as a model system for chemorepellent signaling because its avoidance response is easily characterized under a light microscope. Our experiments showed that netrin-1 peptide is a chemorepellent in T. thermophila at micromolar concentrations...
2016: International Journal of Peptides
https://www.readbyqxmd.com/read/26981137/the-dipeptides-ile-tyr-and-ser-tyr-exert-distinct-effects-on-catecholamine-metabolism-in-the-mouse-brainstem
#3
Kazuki Moriyasu, Takashi Ichinose, Akane Nakahata, Mitsuru Tanaka, Toshiro Matsui, Shigeki Furuya
Catecholamine synthesis and transmission in the brain are influenced by the availability of Tyr in the body. In this study, we compared the effects of oral administration of Tyr-containing dipeptides Ile-Tyr, Ser-Tyr, and Tyr-Pro with Tyr alone on catecholamine metabolism in the mouse brainstem. Among these dipeptides, Ile-Tyr administration led to increases in dopamine, the dopamine metabolites homovanillic acid, and 3,4-dihydroxyphenylacetic acid, compared to administration of Ser-Tyr, Tyr-Pro, or Tyr alone...
2016: International Journal of Peptides
https://www.readbyqxmd.com/read/26843868/high-proteolytic-resistance-of-spider-derived-inhibitor-cystine-knots
#4
Kyoko Kikuchi, Mika Sugiura, Tadashi Kimura
Proteolytic stability in gastrointestinal tract and blood plasma is the major obstacle for oral peptide drug development. Inhibitor cystine knots (ICKs) are linear cystine knot peptides which have multifunctional properties and could become promising drug scaffolds. ProTx-I, ProTx-II, GTx1-15, and GsMTx-4 were spider-derived ICKs and incubated with pepsin, trypsin, chymotrypsin, and elastase in physiological conditions to find that all tested peptides were resistant to pepsin, and ProTx-II, GsMTx-4, and GTx1-15 showed resistance to all tested proteases...
2015: International Journal of Peptides
https://www.readbyqxmd.com/read/26435719/peptide-induced-amyloid-like-conformational-transitions-in-proteins
#5
REVIEW
Vladimir Egorov, Natalia Grudinina, Andrey Vasin, Dmitry Lebedev
Changes in protein conformation can occur both as part of normal protein functioning and during disease pathogenesis. The most common conformational diseases are amyloidoses. Sometimes the development of a number of diseases which are not traditionally related to amyloidoses is associated with amyloid-like conformational transitions of proteins. Also, amyloid-like aggregates take part in normal physiological processes such as memorization and cell signaling. Several primary structural features of a protein are involved in conformational transitions...
2015: International Journal of Peptides
https://www.readbyqxmd.com/read/26413097/proteins-of-bartonella-bacilliformis-candidates-for-vaccine-development
#6
REVIEW
Cesar Henriquez-Camacho, Palmira Ventosilla, Michael F Minnick, Joaquim Ruiz, Ciro Maguiña
Bartonella bacilliformis is the etiologic agent of Carrión's disease or Oroya fever. B. bacilliformis infection represents an interesting model of human host specificity. The notable differences in clinical presentations of Carrión's disease suggest complex adaptations by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins...
2015: International Journal of Peptides
https://www.readbyqxmd.com/read/25972900/correlation-between-saliva-and-plasma-levels-of-endothelin-isoforms-et-1-et-2-and-et-3
#7
Roma Gurusankar, Prem Kumarathasan, Anusha Saravanamuthu, Errol M Thomson, Renaud Vincent
Although saliva endothelins are emerging as valuable noninvasive cardiovascular biomarkers, reports on the relationship between isoforms in saliva and plasma remain scarce. We measured endothelins in concurrent saliva and plasma samples (n = 30 males; age 18-63) by HPLC-fluorescence. Results revealed statistically significant positive correlations among all isoforms between saliva and plasma: big endothelin-1 (BET-1, 0.55 ± 0.27 versus 3.35 ± 1.28 pmol/mL; r = 0.38, p = 0.041), endothelin-1 (ET-1, 0.52 ± 0...
2015: International Journal of Peptides
https://www.readbyqxmd.com/read/25699083/in-silico-conformational-analysis-of-the-short-sequence-hypomurocin-a-peptides
#8
Zoltán Násztor, János Horváth, Balázs Leitgeb
In this theoretical study, a conformational analysis was performed on short-sequence hypomurocin A peptides, in order to identify their characteristic structural properties. For each hypomurocin A molecule, not only the backbone conformations, but also the side-chain conformations were examined. The results indicated that certain tetrapeptide units could be characterized by types I and III β-turn structures, and considering the helical conformations, it could be concluded that the hypomurocin A peptides showed a preference for the 310-helical structure over the α-helical structure...
2015: International Journal of Peptides
https://www.readbyqxmd.com/read/25435884/epithelial-antimicrobial-peptides-guardian-of-the-oral-cavity
#9
REVIEW
Mayank Hans, Veenu Madaan Hans
Gingival epithelium provides first line of defence from the microorganisms present in dental plaque. It not only provides a mechanical barrier but also has an active immune function too. Gingival epithelial cells participate in innate immunity by producing a range of antimicrobial peptides to protect the host against oral pathogens. These epithelial antimicrobial peptides (EAPs) include the β-defensin family, cathelicidin (LL-37), calprotectin, and adrenomedullin. While some are constitutively expressed in gingival epithelial cells, others are induced upon exposure to microbial insults...
2014: International Journal of Peptides
https://www.readbyqxmd.com/read/24834076/cationic-bioactive-peptide-from-the-seeds-of-benincasa-hispida
#10
Sunayana Sharma, Hirday Narain Verma, Nilesh Kumar Sharma
A designated bioactive peptide "Hispidalin" purified from the seeds of Benincasa hispida, which is a medicinal plant, belongs to Cucurbitaceae family. Purification was achieved by using a procedure consisting of extraction from potassium phosphate buffer followed by FPLC and HPLC steps. Based on amino acid residue, this peptide is amphipathic and basic with one net positive charge having isoelectric pH 8.1. This peptide is without sulphur containing amino acid suggesting its extended conformation lacking double bond secondary structure...
2014: International Journal of Peptides
https://www.readbyqxmd.com/read/24688551/recombinant-human-trefoil-factor-3-ameliorates-bowel-injury-its-anti-inflammatory-effect-on-experimental-necrotizing-enterocolitis
#11
Lei Shi, Pang-Hu Zhou, Juan-Li Xi, Hong-Gang Yu, Bing-Hong Zhang
Aim. Recombinant human trefoil factor 3 (intestinal trefoil factor) has been suggested to be partially protective against necrotizing enterocolitis (NEC), but the mechanisms of this protection have not been defined. We investigated whether the protective effects of rhTFF3 are the result of an anti-inflammatory response. Methods. The rats were killed on day 4, the distal ileum was harvested for morphological studies and immunohistochemistry for NF- κ B (p65), and the amounts of IL-1 β , IL-6, and IL-10 in the intestinal tissue were measured using commercial ELISA assay kits...
2014: International Journal of Peptides
https://www.readbyqxmd.com/read/24454411/structural-features-of-the-peptide-homologous-to-6-25-fragment-of-influenza-a-pb1-protein
#12
Vladimir V Egorov, Oleg V Matusevich, Aram A Shaldzhyan, Alexey N Skvortsov, Yana A Zabrodskaya, Yuri P Garmay, Sergey B Landa, Dmitry V Lebedev, Vladimir V Zarubayev, Alexey K Sirotkin, Andrey V Vasin, Oleg I Kiselev
A mirror-symmetry motif was discovered in the N-terminus of the influenza virus PB1 protein. Structure of peptide comprised of the corresponding part of PB1 (amino acid residues 6-25) was investigated by circular dichroism and in silico modeling. We found that peptide PB1 (6-25) in solution assumes beta-hairpin conformation. A truncated peptide PB1 (6-13), containing only half of the mirror-symmetry motif, appeared to stabilize the beta-structure of the original peptide and, at high concentrations, was capable of reacting with peptide to form insoluble aggregates in vitro...
2013: International Journal of Peptides
https://www.readbyqxmd.com/read/24454410/a-systematic-review-to-investigate-whether-angiotensin-1-7-is-a-promising-therapeutic-target-in-human-heart-failure
#13
REVIEW
Vincent C H Lee, Elizabeth N Lloyd, Helena C Dearden, Kenneth Wong
Context. Heart failure (HF) is a common condition causing much morbidity and mortality despite major advances in pharmacological and device therapies. Preclinical data suggest a cardioprotective role of Angiotensin-(1-7) in animal models of HF. Objective. Perform a systematic review on the effects of Angiotensin-(1-7) on humans, focusing on HF. Results. 39 studies were included in the review (4 in human HF and (35) in non-HF patients). There is only one intervention study on 8 patients with human HF, using Angiotensin-(1-7), with forearm blood flow (FBF) as the endpoint...
2013: International Journal of Peptides
https://www.readbyqxmd.com/read/24288548/total-chemical-synthesis-of-a-heterodimeric-interchain-bis-lactam-linked-peptide-application-to-an-analogue-of-human-insulin-like-peptide-3
#14
John Karas, Fazel Shabanpoor, Mohammed Akhter Hossain, James Gardiner, Frances Separovic, John D Wade, Denis B Scanlon
Nonreducible cystine isosteres represent important peptide design elements in that they can maintain a near-native tertiary conformation of the peptide while simultaneously extending the in vitro and in vivo half-life of the biomolecule. Examples of these cystine mimics include dicarba, diselenide, thioether, triazole, and lactam bridges. Each has unique physicochemical properties that impact upon the resulting peptide conformation. Each also requires specific conditions for its formation via chemical peptide synthesis protocols...
2013: International Journal of Peptides
https://www.readbyqxmd.com/read/24027588/development-of-the-schedule-for-multiple-parallel-difficult-peptide-synthesis-on-pins
#15
Ekaterina F Kolesanova, Maxim A Sanzhakov, Oleg N Kharybin
Unified schedule for multiple parallel solid-phase synthesis of so-called "difficult" peptides on polypropylene pins was developed. Increase in the efficiency of 9-fluorenyl(methoxycarbonyl) N-terminal amino-protecting group removal was shown to have a greater influence on the accuracy of the "difficult" peptide synthesis than the use of more efficient amino acid coupling reagents such as aminium salts. Hence the unified schedule for multiple parallel solid-phase synthesis of "difficult" peptides included the procedure for N-terminal amino group deprotection modified by applying a more efficient reagent for the deprotection and the standard procedure of amino acid coupling by carbodiimide method with an additional coupling using aminium salts, if necessary...
2013: International Journal of Peptides
https://www.readbyqxmd.com/read/23970904/antigenic-peptides-capable-of-inducing-specific-antibodies-for-detection-of-the-major-alterations-found-in-type-2b-von-willebrand-disease
#16
Marina de Oliveira Paro, Cyntia Silva Ferreira, Fernanda Silva Vieira, Marcos Aurélio de Santana, William Castro-Borges, Maria Sueli Silva Namen-Lopes, Sophie Yvette Leclercq, Cibele Velloso-Rodrigues, Milton Hércules Guerra de Andrade
Von Willebrand disease (VWD) is an inherited hemorrhagic disorder promoted by either quantitative or qualitative defects of the von Willebrand factor (VWF). The disease represents the most common human coagulopathy afflicting 1.3% of the population. Qualitative defects are subdivided into four subtypes and classified according to the molecular dysfunction of the VWF. The differential diagnosis of the VWD is a difficult task, relying on a panel of tests aimed to assess the plasma levels and function of the VWF...
2013: International Journal of Peptides
https://www.readbyqxmd.com/read/23956755/high-throughput-peptide-epitope-mapping-using-carbon-nanotube-field-effect-transistors
#17
Steingrimur Stefansson, Martha Knight, Hena H Kwon, Lára A Stefansson, Saeyoung Nate Ahn
Label-free and real-time detection technologies can dramatically reduce the time and cost of pharmaceutical testing and development. However, to reach their full promise, these technologies need to be adaptable to high-throughput automation. To demonstrate the potential of single-walled carbon nanotube field-effect transistors (SWCNT-FETs) for high-throughput peptide-based assays, we have designed circuits arranged in an 8 × 12 (96-well) format that are accessible to standard multichannel pipettors. We performed epitope mapping of two HIV-1 gp160 antibodies using an overlapping gp160 15-mer peptide library coated onto nonfunctionalized SWCNTs...
2013: International Journal of Peptides
https://www.readbyqxmd.com/read/23935642/antimicrobial-peptides-versatile-biological-properties
#18
Muthuirulan Pushpanathan, Paramasamy Gunasekaran, Jeyaprakash Rajendhran
Antimicrobial peptides are diverse group of biologically active molecules with multidimensional properties. In recent past, a wide variety of AMPs with diverse structures have been reported from different sources such as plants, animals, mammals, and microorganisms. The presence of unusual amino acids and structural motifs in AMPs confers unique structural properties to the peptide that attribute for their specific mode of action. The ability of these active AMPs to act as multifunctional effector molecules such as signalling molecule, immune modulators, mitogen, antitumor, and contraceptive agent makes it an interesting candidate to study every aspect of their structural and biological properties for prophylactic and therapeutic applications...
2013: International Journal of Peptides
https://www.readbyqxmd.com/read/23878547/amyloid-beta-peptides-differentially-affect-hippocampal-theta-rhythms-in-vitro
#19
Armando I Gutiérrez-Lerma, Benito Ordaz, Fernando Peña-Ortega
Soluble amyloid beta peptide (A β ) is responsible for the early cognitive dysfunction observed in Alzheimer's disease. Both cholinergically and glutamatergically induced hippocampal theta rhythms are related to learning and memory, spatial navigation, and spatial memory. However, these two types of theta rhythms are not identical; they are associated with different behaviors and can be differentially modulated by diverse experimental conditions. Therefore, in this study, we aimed to investigate whether or not application of soluble A β alters the two types of theta frequency oscillatory network activity generated in rat hippocampal slices by application of the cholinergic and glutamatergic agonists carbachol or DHPG, respectively...
2013: International Journal of Peptides
https://www.readbyqxmd.com/read/23737806/nociceptin-signaling-involves-a-calcium-based-depolarization-in-tetrahymena-thermophila
#20
Thomas Lampert, Cheryl Nugent, John Weston, Nathanael Braun, Heather Kuruvilla
Tetrahymena thermophila are free-living, ciliated eukaryotes. Their behavioral response to stimuli is well characterized and easily observable, since cells swim toward chemoattractants and avoid chemorepellents. Chemoattractant responses involve increased swim speed or a decreased change in swim direction, while chemorepellent signaling involves ciliary reversal, which causes the organism to jerk back and forth, swim in small circles, or spin in an attempt to get away from the repellent. Many food sources, such as proteins, are chemoattractants for these organisms, while a variety of compounds are repellents...
2013: International Journal of Peptides
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