journal
MENU ▼
Read by QxMD icon Read
search

Pathology Research International

journal
https://www.readbyqxmd.com/read/29075548/histopathologic-and-cytologic-follow-up-in-high-risk-male-patients-with-unsatisfactory-anal-cytology
#1
Daniel J Zaccarini, Kamal K Khurana
OBJECTIVE: Anal cytology is being increasingly used as part of anal cancer screening in patients at high risk for anal neoplasia. Most studies in anal cytology have focused on correlating the abnormal anal Pap smear with histopathologic outcomes. The aim of this study was to document histopathologic or repeat anal cytology outcomes in patients with unsatisfactory cytology. MATERIALS AND METHODS: Unsatisfactory anal Pap tests in high risk male patients were correlated with follow-up histopathologic diagnoses or cytology...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28835866/an-attempt-to-establish-a-common-animal-model-for-hepatorenal-fibrosis-in-rats
#2
Manoj Hang Limbu, Liu Lei, Cheng Zhengyuan, Liu Jing, Zhang Xiaoyi, Chen Pingsheng
It is already a proven fact that there exists a relationship between CLD (chronic liver disease) and kidney disease but still there is no available combined animal model of liver and kidney fibrosis on the same animal. An animal model is one of the important research tools in the field of medical science because it is important to build a model that can simulate the disease condition so that the particular disease can be studied. Therefore, the aim of this study is to build a less expensive, less time consuming, and reproducible model of hepatorenal fibrosis on rats...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28630781/development-of-neurological-mouse-model-for-toxoplasmosis-using-toxoplasma-gondii-isolated-from-chicken-in-kenya
#3
John Mokua Mose, David Muchina Kamau, John Maina Kagira, Naomi Maina, Maina Ngotho, Adele Njuguna, Simon Muturi Karanja
Animal models for the toxoplasmosis are scarce and have limitations. In this study, a neurological mouse model was developed in BALB/c mice infected intraperitoneally with 15 cysts of a Toxoplasma gondii isolate. The mice were monitored for 42 days and euthanized at different time points. Another group of mice were orally treated with dexamethasone (DXM: 2.66 mg/kg daily, 5.32 mg/kg daily) at 42 days after infection and monitored for a further 42 days. A mortality rate of 15% and 28.6% was observed in mice given 2...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28593065/high-expression-of-galectin-3-in-patients-with-igg4-related-disease-a-proteomic-approach
#4
Adeeb Salah, Hajime Yoshifuji, Shinji Ito, Koji Kitagori, Kaori Kiso, Norishige Yamada, Toshiki Nakajima, Hironori Haga, Tatsuaki Tsuruyama, Aya Miyagawa-Hayashino
OBJECTIVES: Immunoglobulin G4-related disease (IgG4-RD) is a multiorgan condition manifesting itself in different forms. This study aimed to investigate protein expression profiles and to find the possible biomarker for IgG4-RD by liquid chromatography mass spectrometry (LC-MS) using tissue sections in IgG4-RD patients. METHODS: Protein expression profiles in five IgG4-related pancreatitis and three normal pancreatic samples were compared using LC-MS and were validated by quantitative real-time PCR (qRT-PCR), immunoblotting, and immunohistochemistry...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28484662/utility-of-immunohistochemistry-and-etv6-12p13-gene-rearrangement-in-identifying-secretory-carcinoma-of-salivary-gland-among-previously-diagnosed-cases-of-acinic-cell-carcinoma
#5
Rana Naous, Shengle Zhang, Alfredo Valente, Melissa Stemmer, Kamal K Khurana
Objective. Secretory carcinoma is a recently described entity with characteristic immunoprofile and ETV6 (12p13) rearrangement. Before its initial description, it was generally diagnosed as acinic cell carcinoma (ACCi). We evaluated immunoprofile and ETV6 rearrangement in cytological and surgical cases of previously diagnosed ACCi, in an attempt to identify any misclassified SC. Methods. Fifteen cytology and surgical cases of ACCi diagnosed over a 13-year period were retrieved and subjected to immunohistochemistry for S-100, mammaglobin, GATA-3 and DOG-1 as well as FISH for ETV6 (12p13)...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28280647/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-an-evidence-based-nomenclature-change
#6
REVIEW
Rachel Jug, Xiaoyin Jiang
A consensus panel recently used clinical evidence and pathologic parameters to rename noninvasive encapsulated follicular variant of papillary thyroid carcinoma to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) to better reflect the indolent course of this tumor. NIFTP has stringent histopathologic diagnostic criteria established by the panel, including papillary-like nuclear features, and submission of the entire tumor capsule to exclude invasion. From a molecular standpoint, NIFTP is often characterized by RAS-type mutations, similar to other follicular-patterned lesions...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28270943/pathologic-and-radiologic-correlation-of-adult-cystic-lung-disease-a-comprehensive-review
#7
REVIEW
Prajwal Boddu, Vamsi Parimi, Michale Taddonio, Joshua Robert Kane, Anjana Yeldandi
The presence of pulmonary parenchymal cysts on computed tomography (CT) imaging presents a significant diagnostic challenge. The diverse range of possible etiologies can usually be differentiated based on the clinical setting and radiologic features. In fact, the advent of high-resolution CT has facilitated making a diagnosis solely on analysis of CT image patterns, thus averting the need for a biopsy. While it is possible to make a fairly specific diagnosis during early stages of disease evolution by its characteristic radiological presentation, distinct features may progress to temporally converge into relatively nonspecific radiologic presentations sometimes necessitating histological examination to make a diagnosis...
2017: Pathology Research International
https://www.readbyqxmd.com/read/28210516/immunohistochemical-investigation-of-her-akt-mtor-pathway-and-cellular-adhesion-molecules-in-urothelial-carcinomas
#8
Nikolaos Koletsas, Triantafyllia Koletsa, Spyros Choidas, Konstantinos Anagnostopoulos, Stavros Touloupidis, Thomas Zaramboukas, Georgia Raptou, Nikolaos Papadopoulos, Maria Lambropoulou
Background. Several investigators have suggested the possibility that the expression of both EGFR and HER2 could be utilized for molecularly targeted therapy in urinary bladder cancer. We tried to evaluate the expression of HER2 and EGFR and activation of the AKT/PTEN/mTOR pathway in urothelial carcinomas and if there is any association between them and cellular adhesion molecules (CAMs). Materials and Methods. Forty-one paraffin-embedded urothelial cancer tissue blocks were collected. Immunostains for HER2, EGFR, MIB1, phospho-AKT, PTEN, phospho-mTOR, e-cadherin, p-cadherin, and b-catenin were performed on tissue microarrays sections...
2017: Pathology Research International
https://www.readbyqxmd.com/read/27433369/retracted-oral-carcinogenesis-and-oral-cancer-chemoprevention-a-review
#9
Pathology Research International
[This retracts the article DOI: 10.4061/2011/431246.].
2016: Pathology Research International
https://www.readbyqxmd.com/read/27293960/trypanosoma-vivax-adhesion-to-red-blood-cells-in-experimentally-infected-sheep
#10
Alpidio A Boada-Sucre, Marcello Salvatore Rossi Spadafora, Lucinda M Tavares-Marques, Héctor J Finol, Armando Reyna-Bello
Trypanosomosis, a globally occurring parasitic disease, poses as a major obstacle to livestock production in tropical and subtropical regions resulting in tangible economic losses. In Latin America including Venezuela, trypanosomosis of ruminants is mainly caused by Trypanosoma vivax. Biologically active substances produced from trypanosomes, as well as host-trypanosome cellular interactions, contribute to the pathogenesis of anemia in an infection. The aim of this study was to examine with a scanning electron microscope the cellular interactions and alterations in ovine red blood cells (RBC) experimentally infected with T...
2016: Pathology Research International
https://www.readbyqxmd.com/read/27148467/evaluation-of-various-nuclear-cytological-changes-in-normal-buccal-mucosa-and-peritumoural-area-in-patients-with-oral-squamous-cell-carcinoma-receiving-concomitant-chemoradiotherapy
#11
Sadia Minhas, Muhammad Kashif, A H Nagi
Objectives. To evaluate the role of serial cytological assay in calculating the nuclear response of contralateral normal buccal mucosa and peritumoural area of squamous cell carcinoma of oral cavity in patients receiving fractionated radiotherapy (RT) and chemotherapy. Materials and Methods. This prospective, nonrandomized study was comprised of 76 histologically confirmed cases of oral squamous cell carcinoma on cyclical chemoradiation treatment. Chemoradiosensitivity was evaluated using serial scrape smears taken before and after immediate exposure to CCRT, at 17th day of CCRT (mid of treatment), and at the end of treatment...
2016: Pathology Research International
https://www.readbyqxmd.com/read/27088035/a-histomorphological-pattern-analysis-of-pulmonary-tuberculosis-in-lung-autopsy-and-surgically-resected-specimens
#12
Mamta Gupta, Flora D Lobo, Deepa Sowkur Anandarama Adiga, Abhishek Gupta
Background. Tuberculosis (TB) is a major cause of morbidity and mortality globally. Many cases are diagnosed on autopsy and a subset of patients may require surgical intervention either due to the complication or sequelae of TB. Materials and Methods. 40 cases of resected lung specimens following surgery or autopsy in which a diagnosis of pulmonary tuberculosis was made were included. Histopathological pattern analysis of pulmonary tuberculosis along with associated nonneoplastic changes and identification of Mycobacterium tuberculosis bacilli was done...
2016: Pathology Research International
https://www.readbyqxmd.com/read/27022501/the-possible-role-of-mast-cells-in-the-odontogenic-cyst-s-pathogenesis-a-comparative-study-between-dentigerous-cyst-and-keratocystic-odontogenic-tumor
#13
Sareh Farhadi, Fatemeh Shahsavari, MirMahdi Davardan
Background. Recently, mast cells were recognized in the pathogenesis of more aggressive pathologic lesions. This study was aimed to evaluate and compare the density of mast cells in Dentigerous cyst (DC) and Keratocystic odontogenic tumor (KCOT) regarding their different clinical behavior. Method. This study was conducted on 23 and 26 cases of DC and KCOT, respectively. Four-micron sections were prepared for Toluidine blue staining and mast cell densities in two desired cysts were studied. Final data was analyzed via t-test and Mann-Whitney U test method regarding the significant level lower than 0...
2016: Pathology Research International
https://www.readbyqxmd.com/read/26966611/salivary-and-urinary-total-antioxidant-capacity-as-biomarkers-of-oxidative-stress-in-humans
#14
REVIEW
Ilaria Peluso, Anna Raguzzini
Total Antioxidant Capacity (TAC) is a biomarker often used in order to investigate oxidative stress in many pathological conditions. Saliva and urine can be collected noninvasively and represent attractive diagnostic fluids for detecting biomarkers of various pathological conditions. The reviewed case-control and intervention studies that measured salivary or urinary TAC revealed that diseases, antioxidant foods, or supplements and age, gender, and lifestyle factors influenced salivary or urinary TAC. Salivary and urinary TAC were particularly affected by oral or renal status, respectively, as well as by infection; therefore these factors must be taken into account in both case-control and intervention studies...
2016: Pathology Research International
https://www.readbyqxmd.com/read/26904359/immunohistochemical-expression-of-ki67-and-p53-in-wilms-tumor-and-its-relationship-with-tumor-histology-and-stage-at-presentation
#15
O H Radhika Krishna, Geetha Kayla, Mohammed Abdul Aleem, Ramani Malleboyina, Ramesh Reddy Kota
Aim. Evaluate tumor proliferation marker (Ki67) and p53 tumor suppressor marker in Wilms tumor and correlate with histology, anaplasia, and staging. Design. Prospective, hospital based study conducted at a tertiary pediatric referral centre in south India. Setting. Wilms tumor is the most common childhood renal malignancy worldwide. Anaplasia on histology is associated with treatment resistance but not with aggressiveness clinical presentation. Chemotherapy for Wilms tumor is based on histology and staging...
2016: Pathology Research International
https://www.readbyqxmd.com/read/26885438/predictive-response-value-of-pre-and-postchemoradiotherapy-variables-in-rectal-cancer-an-analysis-of-histological-data
#16
Marisa D Santos, Cristina Silva, Anabela Rocha, Carlos Nogueira, Eduarda Matos, Carlos Lopes
Background. Neoadjuvant chemoradiotherapy (nCRT) followed by curative surgery in locally advanced rectal cancer (LARC) improves pelvic disease control. Survival improvement is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response. Potential predictive factors for Mandard response are analyzed. Materials and Methods. 167 patients with LARC were treated with nCRT and curative surgery. Tumor biopsies and surgical specimens were reviewed and analyzed regarding mitotic count, necrosis, desmoplastic reaction, and inflammatory infiltration grade...
2016: Pathology Research International
https://www.readbyqxmd.com/read/26697262/fap-associated-papillary-thyroid-carcinoma-a-peculiar-subtype-of-familial-nonmedullary-thyroid-cancer
#17
REVIEW
Francesco Cetta
Familial Nonmedullary Thyroid Carcinoma (FNMTC) makes up to 5-10% of all thyroid cancers, also including those FNMTC occurring as a minor component of familial cancer syndromes, such as Familial Adenomatous Polyposis (FAP). We give evidence that this extracolonic manifestation of FAP is determined by the same germline mutation of the APC gene responsible for colonic polyps and cancer but also shows some unusual features (F : M ratio = 80 : 1, absence of LOH for APC in the thyroid tumoral tissue, and indolent biological behaviour, despite frequent multicentricity and lymph nodal involvement), suggesting that the APC gene confers only a generic susceptibility to thyroid cancer, but perhaps other factors, namely, modifier genes, sex-related factors, or environmental factors, are also required for its phenotypic expression...
2015: Pathology Research International
https://www.readbyqxmd.com/read/26634172/prognostic-significance-of-n-glycolyl-gm3-ganglioside-expression-in-non-small-cell-lung-carcinoma-patients-new-evidences
#18
Rancés Blanco, Elizabeth Domínguez, Orlando Morales, Damián Blanco, Darel Martínez, Charles E Rengifo, Carmen Viada, Mercedes Cedeño, Enrique Rengifo, Adriana Carr
The prognostic role of N-glycolyl GM3 ganglioside (NeuGcGM3) expression in non-small cell lung carcinoma (NSCLC) still remains controversial. In this study, the NeuGcGM3 expression was reevaluated using an increased number of NSCLC cases and the 14F7 Mab (a highly specific IgG1 raised against NeuGcGM3). An immunohistochemical score integrating the percentage of 14F7-positive cells and the intensity of reaction was applied to reassess the relationship between NeuGcGM3 expression, some clinicopathological features, and the overall survival (OS) of NSCLC patients...
2015: Pathology Research International
https://www.readbyqxmd.com/read/26457223/comparison-of-immunohistochemical-expression-of-antiapoptotic-protein-survivin-in-normal-oral-mucosa-oral-leukoplakia-and-oral-squamous-cell-carcinoma
#19
Amita Negi, Abhiney Puri, Rakhi Gupta, Rajat Nangia, Alisha Sachdeva, Megha Mittal
Background. Oral squamous cell carcinoma is the sixth most frequent malignant tumor worldwide and the third most common cancers in developing countries. Oral leukoplakia is the best-known precursor lesion of oral squamous cell carcinoma. The aim of the present study was to compare immunohistochemical expression of antiapoptotic protein survivin in normal oral mucosa, oral leukoplakia, and oral squamous cell carcinoma. Method. Total 45 specimens of formalin fixed paraffin embedded tissue blocks, 15 in each of the following: normal oral mucosa, leukoplakia, and oral squamous cell carcinoma were used for the study...
2015: Pathology Research International
https://www.readbyqxmd.com/read/25852959/p40-as-a-basal-cell-marker-in-the-diagnosis-of-prostate-glandular-proliferations-a-comparative-immunohistochemical-study-with-34betae12
#20
Hermann Brustmann
Immunohistochemistry is important for the accurate diagnosis of basal cells in atypical glandular proliferations of the prostate. p40, an isoform of p63, may be an adjunct to a marker panel in this setting. Biopsies of 68 patients were analyzed by immunohistochemistry using antibodies to 34betaE12 and p40. Basal cell staining was classified as negative, partial (<60%), or diffuse (≥60%); irregular staining was defined as discordant staining patterns. In acinar proliferations (N = 41), partial staining for both markers was seen in 42%, and diffuse staining in 46% of reactive cases...
2015: Pathology Research International
journal
journal
42919
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"