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Frontiers in Aging Neuroscience

Jessica J van der Zande, Alida A Gouw, Inger van Steenoven, Philip Scheltens, Cornelis Jan Stam, Afina W Lemstra
Introduction : Previous studies on electroencephalography (EEG) to discriminate between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) have been promising. These studies did not consider the pathological overlap of the two diseases. DLB-patients with concomitant AD pathology (DLB/AD+) have a more severe disease manifestation. The EEG may also be influenced by a synergistic effect of the two pathologies. We aimed to compare EEG characteristics between DLB/AD+, "pure" DLB (DLB/AD-) and AD...
2018: Frontiers in Aging Neuroscience
Obada Al Zoubi, Chung Ki Wong, Rayus T Kuplicki, Hung-Wen Yeh, Ahmad Mayeli, Hazem Refai, Martin Paulus, Jerzy Bodurka
Objective: The brain age gap estimate (BrainAGE) is the difference between the estimated age and the individual chronological age. BrainAGE was studied primarily using MRI techniques. EEG signals in combination with machine learning (ML) approaches were not commonly used for the human age prediction, and BrainAGE. We investigated whether age-related changes are affecting brain EEG signals, and whether we can predict the chronological age and obtain BrainAGE estimates using a rigorous ML framework with a novel and extensive EEG features extraction...
2018: Frontiers in Aging Neuroscience
Danyang Tian, Jiao Li, Lu Tang, Nan Zhang, Dongsheng Fan
Previous research has identified CCNF mutations in familial (FALS) and sporadic amyotrophic lateral sclerosis (SALS), as well as in frontotemporal dementia (FTD). The aim of our study was to measure the frequency of CCNF mutations in a Chinese population. In total, 78 FALS patients, 581 SALS patients and 584 controls were included. We found 19 missense mutations, nine synonymous mutations and two intron variants. According to the American College of Medical Genetics and Genomics (ACMG) standards and guidelines for the interpretation of sequence variants, eight variants were judged to be pathogenic or likely pathogenic variants...
2018: Frontiers in Aging Neuroscience
Cristina Lojo-Seoane, David Facal, Joan Guàrdia-Olmos, Arturo X Pereiro, Onésimo Juncos-Rabadán
Objective: Analyze the effects of CR on cognitive performance in adults with subjective cognitive complaints at follow-up. Method: We analyzed the factorial structure of the three constructs defined in cognitive performance (Episodic memory, Working memory, and General cognitive performance) separately to search for evidence of the invariance of the measurement model. We then developed four structural nested models to analyze the relationship between CR and cognitive performance, measured at baseline and after approximately 18 months, in 266 participants older than 50 years with subjective cognitive complaints...
2018: Frontiers in Aging Neuroscience
Hongyan Zhang, Zhaoyang Wang, Yanyan Li, Jiaojiao Han, Chenxi Cui, Chenyang Lu, Jun Zhou, Lingzhi Cheong, Ye Li, Tingting Sun, Dijun Zhang, Xiurong Su
Our previous work indicated that a mixture of tuna oil and algae oil treatment in male mice effectively relieved D-galactose (D-gal)-induced aging and resulted in gut microbiota alterations, and that the best anti-aging effects were observed for a tuna oil to algae oil ratio of 1:2. However, the possibility of a sex-based difference in the anti-aging effect of the tuna oil and algae oil mixture or gut microbiota variation, has rarely been investigated. In this study, the anti-aging effect of an oil mixture (1:2) in male and female mice was measured, and oil treatment improved the learning and cognition of mice that were damaged by D-gal, increased the activities of anti-oxidative enzymes, and decreased the level of MDA, which acted as a hallmark of oxidative damage to lipids...
2018: Frontiers in Aging Neuroscience
Anika M S Hartz, Yu Zhong, Andrew N Shen, Erin L Abner, Björn Bauer
One characteristic of Alzheimer's disease (AD) is excessive accumulation of amyloid-β (Aβ) in the brain. Aβ brain accumulation is, in part, due to a reduction in Aβ clearance from the brain across the blood-brain barrier. One key element that contributes to Aβ brain clearance is P-glycoprotein (P-gp) that transports Aβ from brain to blood. In AD, P-gp protein expression and transport activity levels are significantly reduced, which impairs Aβ brain clearance. The mechanism responsible for reduced P-gp expression and activity levels is poorly understood...
2018: Frontiers in Aging Neuroscience
Zhicai Chen, Ruiting Zhang, Feizhou Xu, Xiaoxian Gong, Feina Shi, Meixia Zhang, Min Lou
Background : Identifying large vessel occlusion (LVO) patients in the prehospital triage stage to avoid unnecessary and costly delays is important but still challenging. We aim to develop an artificial neural network (ANN) algorithm to predict LVO using prehospital accessible data including demographics, National Institutes of Health Stroke Scale (NIHSS) items and vascular risk factors. Methods : Consecutive acute ischemic stroke patients who underwent CT angiography (CTA) or time of flight MR angiography (TOF-MRA) and received reperfusion therapy within 8 h from symptom onset were included...
2018: Frontiers in Aging Neuroscience
Isabelle Bos, Stephanie J B Vos, Willemijn J Jansen, Rik Vandenberghe, Silvy Gabel, Ainara Estanga, Mirian Ecay-Torres, Jori Tomassen, Anouk den Braber, Alberto Lleó, Isabel Sala, Anders Wallin, Petronella Kettunen, José L Molinuevo, Lorena Rami, Gaël Chetelat, Vincent de la Sayette, Magda Tsolaki, Yvonne Freund-Levi, Peter Johannsen, Gerald P Novak, Inez Ramakers, Frans R Verhey, Pieter Jelle Visser
We investigated whether amyloid-β (Aβ) and tau affected cognition in cognitively normal (CN) individuals, and whether norms for neuropsychological tests based on biomarker-negative individuals would improve early detection of dementia. We included 907 CN individuals from 8 European cohorts and from the Alzheimer's disease Neuroimaging Initiative. All individuals were aged above 40, had Aβ status and neuropsychological data available. Linear mixed models were used to assess the associations of Aβ and tau with five neuropsychological tests assessing memory (immediate and delayed recall of Auditory Verbal Learning Test, AVLT), verbal fluency (Verbal Fluency Test, VFT), attention and executive functioning (Trail Making Test, TMT, part A and B)...
2018: Frontiers in Aging Neuroscience
Sachchida N Rai, Walia Zahra, Hareram Birla, Saumitra S Singh, Surya P Singh
No abstract text is available yet for this article.
2018: Frontiers in Aging Neuroscience
Huan Liao, Zhuoting Zhu, Ying Peng
The ensuing upward shift in demographic distribution due to the increase in life expectancy has resulted in a rising prevalence of Alzheimer's disease (AD). The heavy public burden of AD, along with the urgent to prevent and treat the disease before the irreversible damage to the brain, calls for a sensitive and specific screening technology to identify high-risk individuals before cognitive symptoms arise. Even though current modalities, such as positron emission tomography (PET) and cerebrospinal fluid (CSF) biomarker, showed their potential clinical uses in early detection of AD, the high cost, narrow isotope availability of PET probes and invasive characteristics of CSF biomarker limited their broad utility...
2018: Frontiers in Aging Neuroscience
Elizabeth Head, David K Powell, Frederick A Schmitt
People with Down syndrome (DS) are at high risk for developing Alzheimer disease (AD). Neuropathology consistent with AD is present by 40 years of age and dementia may develop up to a decade later. In this review, we describe metabolic and vascular neuroimaging studies in DS that suggest these functional changes are a key feature of aging, linked to cognitive decline and AD in this vulnerable cohort. FDG-PET imaging in DS suggests systematic reductions in glucose metabolism in posterior cingulate and parietotemporal cortex...
2018: Frontiers in Aging Neuroscience
Lin Sun, Hua Xu, Jie Zhang, Wei Li, Jing Nie, Qi Qiu, Yuanyuan Liu, Yuan Fang, Zhi Yang, Xia Li, Shifu Xiao
Background: Binge drinking of alcohol is associated with brain damage, but less is known about relationship of light-to-moderate alcohol consumption with cognitive function, biochemical indexes, and cortical anatomy. Previous findings have debated on whether light-to-moderate drinking has any health benefits. We investigated cortical thickness and its association with alcohol consumption and cognitive functions in a non-dementia aging Han Chinese population. Methods: 940 non-dementia aging subjects were included in our study (alcohol n = 149; non-alcohol n = 791)...
2018: Frontiers in Aging Neuroscience
Jieshan Chi, Qizhi Xie, Jingjing Jia, Xiaoma Liu, Jingjing Sun, Yuanfei Deng, Li Yi
Parkinson's disease (PD) is a quite common neurodegenerative disorder with a prevalence of approximately 1:800-1,000 in subjects over 60 years old. The aim of our study was to determine the candidate target genes in PD through meta-analysis of multiple gene expression arrays datasets and to further combine mRNA and miRNA expression analyses to identify more convincing biological targets and their regulatory factors. Six included datasets were obtained from the Gene Expression Omnibus database by systematical search, including five mRNA datasets (150 substantia nigra samples in total) and one miRNA dataset containing 32 peripheral blood samples...
2018: Frontiers in Aging Neuroscience
Ling-Yun Fan, Kai-Yuan Tzen, Ya-Fang Chen, Ta-Fu Chen, Ya-Mei Lai, Ruoh-Fang Yen, Ya-Yao Huang, Chyng-Yann Shiue, Shieh-Yueh Yang, Ming-Jang Chiu
Background: Neuritic plaques and neurofibrillary tangles are the pathological hallmarks of Alzheimer's disease (AD), while the role of brain amyloid deposition in the clinical manifestation or brain atrophy remains unresolved. We aimed to explore the relation between brain amyloid deposition, cortical thickness, and plasma biomarkers. Methods: We used 11 C-Pittsburgh compound B-positron emission tomography to assay brain amyloid deposition, magnetic resonance imaging to estimate cortical thickness, and an immunomagnetic reduction assay to measure plasma biomarkers...
2018: Frontiers in Aging Neuroscience
Jason A Brandon, Brandon C Farmer, Holden C Williams, Lance A Johnson
Apolipoprotein E4 (ApoE4) is the strongest genetic risk factor for late onset Alzheimer's Disease (AD), and is associated with impairments in cerebral metabolism and cerebrovascular function. A substantial body of literature now points to E4 as a driver of multiple impairments seen in AD, including blunted brain insulin signaling, mismanagement of brain cholesterol and fatty acids, reductions in blood brain barrier (BBB) integrity, and decreased cerebral glucose uptake. Various neuroimaging techniques, in particular positron emission topography (PET) and magnetic resonance imaging (MRI), have been instrumental in characterizing these metabolic and vascular deficits associated with this important AD risk factor...
2018: Frontiers in Aging Neuroscience
Harri Piitulainen, Santtu Seipäjärvi, Janne Avela, Tiina Parviainen, Simon Walker
Proprioceptive perception is impaired with aging, but little is known about aging-related deterioration of proprioception at the cortical level. Corticokinematic coherence (CKC) between limb kinematic and magnetoencephalographic (MEG) signals reflects cortical processing of proprioceptive afference. We, thus, compared CKC strength to ankle movements between younger and older subjects, and examined whether CKC predicts postural stability. Fifteen younger (range 18-31 years) and eight older (66-73 years) sedentary volunteers were seated in MEG, while their right and left ankle joints were moved separately at 2 Hz (for 4 min each) using a novel MEG-compatible ankle-movement actuator...
2018: Frontiers in Aging Neuroscience
Rumi Ueha, Satoshi Ueha, Kenji Kondo, Shu Kikuta, Tatsuya Yamasoba
Introduction : Exposure to cigarette smoke is a cause of olfactory dysfunction. We previously reported that in young mice, cigarette smoke damaged olfactory progenitors and decreased mature olfactory receptor neurons (ORNs), then, mature ORNs gradually recovered after smoking cessation. However, in aged populations, the target cells in ORNs by cigarette smoke, the underlying molecular mechanisms by which cigarette smoke impairs the regenerative ORNs, and the degree of ORN regeneration after smoking cessation remain unclear...
2018: Frontiers in Aging Neuroscience
Joyce Gomes-Osman, Aprinda Indahlastari, Peter J Fried, Danylo L F Cabral, Jordyn Rice, Nicole R Nissim, Serkan Aksu, Molly E McLaren, Adam J Woods
The impact of cognitive aging on brain function and structure is complex, and the relationship between aging-related structural changes and cognitive function are not fully understood. Physiological and pathological changes to the aging brain are highly variable, making it difficult to estimate a cognitive trajectory with which to monitor the conversion to cognitive decline. Beyond the information on the structural and functional consequences of cognitive aging gained from brain imaging and neuropsychological studies, non-invasive brain stimulation techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) can enable stimulation of the human brain in vivo , offering useful insights into the functional integrity of intracortical circuits using electrophysiology and neuromodulation...
2018: Frontiers in Aging Neuroscience
Hao Tian, Yongquan Lu, Jia Liu, Weijin Liu, Lingling Lu, Chunli Duan, Ge Gao, Hui Yang
The pathology of Parkinson's disease (PD) is characterized by intracellular neurofibrillary tangles of phosphorylated α-synuclein (α-syn). Protein phosphatase 2A (PP2A) is responsible for α-syn dephosphorylation. Previous work has demonstrated that α-syn can regulate PP2A activity. However, the mechanisms underlying α-syn regulation of PP2A activity are not well understood. In this study, we found that α-syn overexpression induced increased α-syn phosphorylation at serine 129 (Ser129), and PP2A inhibition, in vitro and in vivo ...
2018: Frontiers in Aging Neuroscience
Alice E Kane, Sooyoun Shin, Aimee A Wong, Emre Fertan, Natalia S Faustova, Susan E Howlett, Richard E Brown
Mouse models of Alzheimer's disease (AD) exhibit marked differences in life expectancy depending on their genotype and sex. The assessment of frailty could provide a measure of healthspan to facilitate comparisons between different AD models. We used a validated mouse frailty index (FI) assessment tool to explore genotype and sex differences in lifespan and healthspan of 3xTg-AD mice and their B6129F2 wild-type (WT) controls. This tool is based on an approach commonly used in people and quantifies frailty by counting the accumulation of age-related health deficits...
2018: Frontiers in Aging Neuroscience
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