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International Journal of Alzheimer's Disease

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https://www.readbyqxmd.com/read/27774333/comparing-cognitive-profiles-of-licensed-drivers-with-mild-alzheimer-s-disease-and-mild-dementia-with-lewy-bodies
#1
Stephanie Yamin, Arne Stinchcombe, Sylvain Gagnon
Purpose. Alzheimer's disease (AD) and dementia with Lewy Bodies (DLB) constitute two of the most common forms of dementia in North America. Driving is a primary means of mobility among older adults and the risk of dementia increases with advanced age. The purpose of this paper is to describe the cognitive profile of licensed drivers with mild AD and mild DLB. Method. Licensed drivers with mild AD, mild DLB, and healthy controls completed neuropsychological tests measuring general cognition, attention, visuospatial/perception, language, and cognitive fluctuations...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27672476/expression-of-phenotypic-astrocyte-marker-is-increased-in-a-transgenic-mouse-model-of-alzheimer-s-disease-versus-age-matched-controls-a-presymptomatic-stage-study
#2
Aurélie Doméné, Chelsea Cavanagh, Guylène Page, Sylvie Bodard, Christophe Klein, Cécile Delarasse, Sylvie Chalon, Slavica Krantic
Recent mouse studies of the presymptomatic stage of Alzheimer's disease (AD) have suggested that proinflammatory changes, such as glial activation and cytokine induction, may occur already at this early stage through unknown mechanisms. Because TNFα contributes to increased Aβ production from the Aβ precursor protein (APP), we assessed a putative correlation between APP/Aβ and TNFα during the presymptomatic stage as well as early astrocyte activation in the hippocampus of 3-month-old APPswe/PS1dE9 mice...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27478677/the-acceptability-and-usefulness-of-cognitive-stimulation-therapy-for-older-adults-with-dementia-a-narrative-review
#3
REVIEW
Hui Moon Toh, Shazli Ezzat Ghazali, Ponnusamy Subramaniam
Cognitive stimulation therapy (CST) is an evidence-based therapy for individuals with mild-to-moderate dementia. Past reviews have only synthesized outcomes obtained through quantitative study which does not fully represent the understanding on the acceptability and usefulness of CST. Therefore, the present review aims to integrate outcomes obtained from both quantitative and qualitative studies to provide a deeper understanding on the acceptability and usefulness of CST for older adults with dementia. Findings of literature were retrieved from searches of computerized databases in relation to CST for people with dementia...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27413574/family-dynamics-and-personal-strengths-among-dementia-caregivers-in-argentina
#4
Aaliah G Elnasseh, Michael A Trujillo, Silvina Victoria Peralta, Miriam E Stolfi, Eliana Morelli, Paul B Perrin, Juan Carlos Arango-Lasprilla
This study examined whether healthier family dynamics were associated with higher personal strengths of resilience, sense of coherence, and optimism among dementia caregivers in Argentina. Caregivers are usually required to assist individuals with dementia, and family members have typically fulfilled that role. Personal strengths such as resilience, sense of coherence, and optimism have been shown to protect caregivers from some of the negative experiences of providing care, though the family-related variables associated with these personal strengths are largely unknown...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27213078/nanoscale-extracellular-vesicle-analysis-in-alzheimer-s-disease-diagnosis-and-therapy
#5
REVIEW
Pete Heinzelman, Tina Bilousova, Jesus Campagna, Varghese John
Diagnostic assays that leverage bloodborne neuron-derived (neuronal) nanoscale extracellular vesicles (nsEVs) as "windows into the brain" can predict incidence of Alzheimer's Disease (AD) many years prior to onset. Beyond diagnostics, bloodborne neuronal nsEVs analysis may have substantial translational impact by revealing mechanisms of AD pathology; such knowledge could enlighten new drug targets and lead to new therapeutic approaches. The potential to establish three-dimensional nsEV analysis methods that characterize highly purified bloodborne nsEV populations in method of enrichment, cell type origin, and protein or RNA abundance dimensions could bring this promise to bear by yielding nsEV "omics" datasets that uncover new AD biomarkers and enable AD therapeutic development...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26977333/medical-students-perceptions-of-dementia-after-participation-in-poetry-workshop-with-people-with-dementia
#6
Alaina J Garrie, Shruti Goel, Martin M Forsberg
Purpose. Researchers assessed whether medical students' participation in a poetry workshop with people with Alzheimer's disease and related dementias (ADRD) affected their attitudes towards persons with ADRD. Objective. To add to the growing body of research summarizing the impact of nonclinical interventions on medical students' perspectives about people with ADRD. Design. Researchers used dementia attitudes scale (DAS) and interpretive phenomenological analysis (IPA) to analyze participants' attitudes. Setting...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26713169/driving-competence-in-mild-dementia-with-lewy-bodies-in-search-of-cognitive-predictors-using-driving-simulation
#7
Stephanie Yamin, Arne Stinchcombe, Sylvain Gagnon
Driving is a multifactorial behaviour drawing on multiple cognitive, sensory, and physical systems. Dementia is a progressive and degenerative neurological condition that impacts the cognitive processes necessary for safe driving. While a number of studies have examined driving among individuals with Alzheimer's disease, less is known about the impact of Dementia with Lewy Bodies (DLB) on driving safety. The present study compared simulated driving performance of 15 older drivers with mild DLB with that of 21 neurologically healthy control drivers...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26664821/alzheimer-s-disease-exploring-the-role-of-inflammation-and-implications-for-treatment
#8
REVIEW
Mark E McCaulley, Kira A Grush
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by both structural abnormalities and inflammation in the brain. While recent research has chiefly focused on the structural changes involved in AD, understanding the pathophysiology and associated inflammation of the AD brain helps to elucidate potential therapeutic and preventative options. By exploring the data supporting an inflammatory etiology of AD, we present a case for the use of existing evidence-based treatments addressing inflammation as promising options for treating and preventing AD...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26600964/pet-imaging-of-epigenetic-influences-on-alzheimer-s-disease
#9
REVIEW
Paul J Couto, Richard M Millis
The precise role of environment-gene interactions (epigenetics) in the development and progression of Alzheimer's disease (AD) is unclear. This review focuses on the premise that radiotracer-specific PET imaging allows clinicians to visualize epigenetically influenced events and that such imaging may provide new, valuable insights for preventing, diagnosing, and treating AD. Current understanding of the role of epigenetics in AD and the principles underlying the use of PET radiotracers for in vivo diagnosis are reviewed...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26351614/vitamin-d-and-alzheimer-s-disease-neurocognition-to-therapeutics
#10
REVIEW
Anindita Banerjee, Vineet Kumar Khemka, Anirban Ganguly, Debashree Roy, Upasana Ganguly, Sasanka Chakrabarti
Alzheimer's disease (AD), the major cause of dementia worldwide, is characterized by progressive loss of memory and cognition. The sporadic form of AD accounts for nearly 90% of the patients developing this disease. The last century has witnessed significant research to identify various mechanisms and risk factors contributing to the complex etiopathogenesis of AD by analyzing postmortem AD brains and experimenting with animal and cell culture based models. However, the treatment strategies, as of now, are only symptomatic...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26257978/evaluating-adult-s-competency-application-of-the-competency-assessment-process
#11
Dominique Giroux, Sylvie Tétreault, Marie-Pier Landry
Competency assessment of adults with cognitive impairment or mental illness is a complex process that can have significant consequences for their rights. Some models put forth in the scientific literature have been proposed to guide health and social service professionals with this assessment process, but none of these appear to be complete. A new model, the Competency Assessment Process (CAP), was presented and validated in other studies. This paper adds to this corpus by presenting both the CAP model and the results of a survey given to health and social service professionals on its practical application in their clinical practice...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26171273/auditory-and-visual-cues-for-topic-maintenance-with-persons-who-exhibit-dementia-of-alzheimer-s-type
#12
Amy F Teten, Paul A Dagenais, Mary J Friehe
This study compared the effectiveness of auditory and visual redirections in facilitating topic coherence for persons with Dementia of Alzheimer's Type (DAT). Five persons with moderate stage DAT engaged in conversation with the first author. Three topics related to activities of daily living, recreational activities, food, and grooming, were broached. Each topic was presented three times to each participant: once as a baseline condition, once with auditory redirection to topic, and once with visual redirection to topic...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/25821630/inhibitory-effects-of-sodium-arsenite-and-acacia-honey-on-acetylcholinesterase-in-rats
#13
Aliyu Muhammad, Oyeronke A Odunola, Michael A Gbadegesin, Abdullahi B Sallau, Uche S Ndidi, Mohammed A Ibrahim
This study was conducted to investigate the effect of sodium arsenite and Acacia honey on acetylcholinesterase (AChE) activity and electrolytes in the brain and serum of Wistar rats. Male Wistar albino rats in four groups of five rats each were treated with distilled water, sodium arsenite (5 mg/kg body weight), Acacia honey (20% v/v), and sodium arsenite and Acacia honey, daily for one week. The sodium arsenite and Acacia honey significantly (P < 0.05) decreased AChE activity in the brain with the combined treatment being more potent...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/25810947/beneficial-effects-of-teucrium-polium-and-metformin-on-diabetes-induced-memory-impairments-and-brain-tissue-oxidative-damage-in-rats
#14
S Mojtaba Mousavi, Saeed Niazmand, Mahmoud Hosseini, Zarha Hassanzadeh, Hamid Reza Sadeghnia, Farzaneh Vafaee, Zakieh Keshavarzi
Objective. The effects of hydroalcoholic extract of Teucrium polium and metformin on diabetes-induced memory impairment and brain tissues oxidative damage were investigated. Methods. The rats were divided into: (1) Control, (2) Diabetic, (3) Diabetic-Extract 100 (Dia-Ext 100), (4) Diabetic-Extract 200 (Dia-Ext 200), (5) Diabetic-Extract 400 (Dia-Ext 400), and (6) Diabetic-Metformin (Dia-Met). Groups 3-6 were treated by 100, 200, and 400 mg/kg of the extract or metformin, respectively, for 6 weeks (orally)...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/25544932/playing-a-musical-instrument-as-a-protective-factor-against-dementia-and-cognitive-impairment-a-population-based-twin-study
#15
M Alison Balbag, Nancy L Pedersen, Margaret Gatz
Increasing evidence supports that playing a musical instrument may benefit cognitive development and health at young ages. Whether playing an instrument provides protection against dementia has not been established. In a population-based cotwin control study, we examined the association between playing a musical instrument and whether or not the twins developed dementia or cognitive impairment. Participation in playing an instrument was taken from informant-based reports of twins' leisure activities. Dementia diagnoses were based on a complete clinical workup using standard diagnostic criteria...
2014: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/25506036/anticholinesterase-and-antioxidative-properties-of-aqueous-extract-of-cola-acuminata-seed-in-vitro
#16
Ganiyu Oboh, Ayodele J Akinyemi, Olasunkanmi S Omojokun, Idowu S Oyeleye
Background. Cola acuminata seed, a commonly used stimulant in Nigeria, has been reportedly used for the management of neurodegenerative diseases in folklore without scientific basis. This study sought to investigate the anticholinesterase and antioxidant properties of aqueous extracts from C. acuminata seed in vitro. Methodology. The aqueous extract of C. acuminata seed was prepared (w/v) and its effect on acetylcholinesterase (AChE) and butyrylcholinesterase activities, as well as some prooxidant (FeSO4, sodium nitroprusside (SNP), and quinolinic acid (QA)) induced lipid peroxidation in rat brain in vitro, was investigated...
2014: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/25328754/enhancing-resourcefulness-to-improve-outcomes-in-family-caregivers-and-persons-with-alzheimer-s-disease-a-pilot-randomized-trial
#17
Elizabeth W Gonzalez, Marcia Polansky, Carol F Lippa, Laura N Gitlin, Jaclene A Zauszniewski
This pilot randomized trial tested an intervention aimed at enhancing resourcefulness in family caregivers of persons with dementia, postulating that caregivers' emotional outcomes (anxiety and depression) and role outcomes (reward, strain, mutuality, and preparedness) would be improved, and problem behaviors in the care recipients (persons with dementia) would be reduced as a result of the intervention. Subjects were stratified by race (white or African American) and by baseline resourcefulness (high or low)...
2014: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/25309772/the-role-of-the-blood-brain-barrier-in-the-pathogenesis-of-senile-plaques-in-alzheimer-s-disease
#18
J Provias, B Jeynes
The accumulation of beta-amyloid [Aβ] within senile plaques [SP] is characteristic of these lesions in Alzheimer's disease. The accumulation of Aβ 42, in particular, in the superior temporal [ST] cortex may result from an inability of the blood brain barrier (BBB) to regulate the trans-endothelial transport and clearance of the amyloid. Lipoprotein receptor-related protein [LRP] and P-glycoprotein [P-gp] facilitate the efflux of Aβ out of the brain, whereas receptor for advanced glycation end products [RAGE] facilitates Aβ influx...
2014: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/25254139/high-dimensional-medial-lobe-morphometry-an-automated-mri-biomarker-for-the-new-ad-diagnostic-criteria
#19
Simon Duchesne, Fernando Valdivia, Abderazzak Mouiha, Nicolas Robitaille
Introduction. Medial temporal lobe atrophy assessment via magnetic resonance imaging (MRI) has been proposed in recent criteria as an in vivo diagnostic biomarker of Alzheimer's disease (AD). However, practical application of these criteria in a clinical setting will require automated MRI analysis techniques. To this end, we wished to validate our automated, high-dimensional morphometry technique to the hypothetical prediction of future clinical status from baseline data in a cohort of subjects in a large, multicentric setting, compared to currently known clinical status for these subjects...
2014: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/25243093/comparison-of-the-inhibition-of-monoamine-oxidase-and-butyrylcholinesterase-activities-by-infusions-from-green-tea-and-some-citrus-peels
#20
Ayokunle O Ademosun, Ganiyu Oboh
This study sought to investigate the effect of infusions from green tea (Camellia sinensis) and some citrus peels [shaddock (Citrus maxima), grapefruit (Citrus paradisi), and orange (Citrus sinensis)] on key enzymes relevant to the management of neurodegenerative conditions [monoamine oxidase (MAO) and butyrylcholinesterase (BChE)]. The total phenol contents and antioxidant activities as typified by their 2,2(')-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radicals scavenging abilities, ferric reducing antioxidant properties, and Fe(2+) chelating abilities were also investigated...
2014: International Journal of Alzheimer's Disease
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