Lidia Lopez-Gutierrez, José María García-Alberca, Silvia Mendoza, Esther Gris, María Paz De la Guía, José Manuel Marin-Carmona, Emilio Alarcón-Martín, Almudena Lobato, Jose Manuel Cruz-Gamero, Laura Cura, Olga Ocejo, Javier Torrecilla, María Dolores Nieto, Concepción Urbano, Nuria Pareja, Macarena Luque, María García-Peralta, Rosario Carrillejo, José Luis Royo
Alzheimer's disease is the most common cause of dementia worldwide, and longitudinal studies are crucial to find the factors affecting disease development. Here, we describe a novel initiative from southern Spain designed to contribute in the identification of the genetic component of the cognitive decline of Alzheimer's disease patients. The germline variant rs9320913 is a C>A substitution mapping within a gene desert. Although it has been previously associated to a higher educational achievement and increased fluid intelligence, its role on Alzheimer's disease risk and progression remains elusive...
2021: International Journal of Alzheimer's Disease