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International Journal of Alzheimer's Disease

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https://www.readbyqxmd.com/read/28573062/regional-cerebral-blood-flow-in-mild-cognitive-impairment-and-alzheimer-s-disease-measured-with-arterial-spin-labeling-magnetic-resonance-imaging
#1
REVIEW
Alba Sierra-Marcos
Alzheimer's disease (AD) depicts dynamic changes in regional brain function from early stages of the disease. Arterial spin labeling- (ASL-) based MRI methods have been applied for detecting regional cerebral blood flow (rCBF) perfusion changes in patients with AD and mild cognitive impairment (MCI). Nevertheless, the results obtained from ASL studies in AD and MCI are still controversial, since rCBF maps may show both hypoperfusion or hyperperfusion areas in brain structures involved in different cognitive functions...
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/28567323/comparative-neuroprotective-effects-of-dietary-curcumin-and-solid-lipid-curcumin-particles-in-cultured-mouse-neuroblastoma-cells-after-exposure-to-a%C3%AE-42
#2
Panchanan Maiti, Gary L Dunbar
Aggregation of amyloid beta protein (Aβ) and phosphorylated tau (p-Tau) plays critical roles in pathogenesis of Alzheimer's disease (AD). As an antiamyloid natural polyphenol, curcumin (Cur) has a potential role in prevention of neurodegeneration in AD. However, due to limited absorption of the dietary Cur, the solid lipid Cur particles (SLCP) have been suggested as being more effective for AD therapy. In the present study, we compared the role of dietary Cur and SLCP on oxidative stress, neuronal death, p-Tau level, and certain cell survival markers in vitro, after exposure to Aβ42...
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/28484660/major-depressive-symptoms-increase-3-year-mortality-rate-in-patients-with-mild-dementia
#3
Jindong Ding Petersen, Frans Boch Waldorff, Volkert Dirk Siersma, Thien Kieu Thi Phung, Anna Carina Klara Magdalena Bebe, Gunhild Waldemar
Depression and dementia are commonly concurrent and are both associated with increased mortality among older people. However, little is known about whether home-dwelling patients newly diagnosed with mild dementia coexisting with depressive symptoms have excess mortality. We conducted a post hoc analysis based on data from the Danish Alzheimer's Intervention Study of 330 individuals who were diagnosed with mild dementia within the past 12 months. Thirty-four patients were identified with major depressive symptoms (MD-S) at baseline...
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/28469949/corrigendum-to-alzheimer-s-disease-dementia-as-the-diagnosis-best-supported-by-the-cerebrospinal-fluid-biomarkers-difference-in-cut-off-levels-from-thai-experience
#4
Vorapun Senanarong, Nobdham Sivasariyanonda, Leatchai Wachirutmanggur, Niphon Poungvarin, Chatchawan Rattanabannakit, Nuttapol Aoonkaew, Suthipol Udompunthurak
[This corrects the article DOI: 10.1155/2012/212063.].
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/28255496/diagnostic-accuracy-of-the-overlapping-infinity-loops-wire-cube-and-clock-drawing-tests-for-cognitive-impairment-in-mild-cognitive-impairment-and-dementia
#5
Thammanard Charernboon
Purpose. To investigate the diagnostic accuracy of the overlapping infinity loops, wire cube, and clock drawing tests (CDT) in the detection of mild cognitive impairment (MCI) and dementia. Method. The participants were 60 normal controls (NC), 35 patients with MCI, and 47 patients with mild dementia. Results. The results illustrate that infinity loops, cube, or CDT were not able to discriminate between NC and MCI groups. In dementia detection, the CDT had the highest diagnostic accuracy (sensitivity 76.6% and specificity 87...
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/28083154/assessment-of-health-related-quality-of-life-for-caregivers-of-alzheimer-s-disease-patients
#6
Maria I Andreakou, Angelos A Papadopoulos, Demosthenes B Panagiotakos, Dimitris Niakas
Background. Alzheimer's disease (AD) dementia is a chronic neurodegenerative disorder that results in total cognitive impairment and functional decline. Family members are the most usual caregivers worldwide, resulting in a subsequent degradation of their quality of life. Methods. During November 2013-March 2014 in Athens, Greece, 155 AD patients' family caregivers' Health-Related Quality of Life and existence of depressive symptomatology were assessed. Results. A strong negative correlation between the dimensions of HRQoL and the scores of the depression scale was revealed...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27774333/comparing-cognitive-profiles-of-licensed-drivers-with-mild-alzheimer-s-disease-and-mild-dementia-with-lewy-bodies
#7
Stephanie Yamin, Arne Stinchcombe, Sylvain Gagnon
Purpose. Alzheimer's disease (AD) and dementia with Lewy Bodies (DLB) constitute two of the most common forms of dementia in North America. Driving is a primary means of mobility among older adults and the risk of dementia increases with advanced age. The purpose of this paper is to describe the cognitive profile of licensed drivers with mild AD and mild DLB. Method. Licensed drivers with mild AD, mild DLB, and healthy controls completed neuropsychological tests measuring general cognition, attention, visuospatial/perception, language, and cognitive fluctuations...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27672476/expression-of-phenotypic-astrocyte-marker-is-increased-in-a-transgenic-mouse-model-of-alzheimer-s-disease-versus-age-matched-controls-a-presymptomatic-stage-study
#8
Aurélie Doméné, Chelsea Cavanagh, Guylène Page, Sylvie Bodard, Christophe Klein, Cécile Delarasse, Sylvie Chalon, Slavica Krantic
Recent mouse studies of the presymptomatic stage of Alzheimer's disease (AD) have suggested that proinflammatory changes, such as glial activation and cytokine induction, may occur already at this early stage through unknown mechanisms. Because TNFα contributes to increased Aβ production from the Aβ precursor protein (APP), we assessed a putative correlation between APP/Aβ and TNFα during the presymptomatic stage as well as early astrocyte activation in the hippocampus of 3-month-old APPswe/PS1dE9 mice...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27478677/the-acceptability-and-usefulness-of-cognitive-stimulation-therapy-for-older-adults-with-dementia-a-narrative-review
#9
REVIEW
Hui Moon Toh, Shazli Ezzat Ghazali, Ponnusamy Subramaniam
Cognitive stimulation therapy (CST) is an evidence-based therapy for individuals with mild-to-moderate dementia. Past reviews have only synthesized outcomes obtained through quantitative study which does not fully represent the understanding on the acceptability and usefulness of CST. Therefore, the present review aims to integrate outcomes obtained from both quantitative and qualitative studies to provide a deeper understanding on the acceptability and usefulness of CST for older adults with dementia. Findings of literature were retrieved from searches of computerized databases in relation to CST for people with dementia...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27413574/family-dynamics-and-personal-strengths-among-dementia-caregivers-in-argentina
#10
Aaliah G Elnasseh, Michael A Trujillo, Silvina Victoria Peralta, Miriam E Stolfi, Eliana Morelli, Paul B Perrin, Juan Carlos Arango-Lasprilla
This study examined whether healthier family dynamics were associated with higher personal strengths of resilience, sense of coherence, and optimism among dementia caregivers in Argentina. Caregivers are usually required to assist individuals with dementia, and family members have typically fulfilled that role. Personal strengths such as resilience, sense of coherence, and optimism have been shown to protect caregivers from some of the negative experiences of providing care, though the family-related variables associated with these personal strengths are largely unknown...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27213078/nanoscale-extracellular-vesicle-analysis-in-alzheimer-s-disease-diagnosis-and-therapy
#11
REVIEW
Pete Heinzelman, Tina Bilousova, Jesus Campagna, Varghese John
Diagnostic assays that leverage bloodborne neuron-derived (neuronal) nanoscale extracellular vesicles (nsEVs) as "windows into the brain" can predict incidence of Alzheimer's Disease (AD) many years prior to onset. Beyond diagnostics, bloodborne neuronal nsEVs analysis may have substantial translational impact by revealing mechanisms of AD pathology; such knowledge could enlighten new drug targets and lead to new therapeutic approaches. The potential to establish three-dimensional nsEV analysis methods that characterize highly purified bloodborne nsEV populations in method of enrichment, cell type origin, and protein or RNA abundance dimensions could bring this promise to bear by yielding nsEV "omics" datasets that uncover new AD biomarkers and enable AD therapeutic development...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26977333/medical-students-perceptions-of-dementia-after-participation-in-poetry-workshop-with-people-with-dementia
#12
Alaina J Garrie, Shruti Goel, Martin M Forsberg
Purpose. Researchers assessed whether medical students' participation in a poetry workshop with people with Alzheimer's disease and related dementias (ADRD) affected their attitudes towards persons with ADRD. Objective. To add to the growing body of research summarizing the impact of nonclinical interventions on medical students' perspectives about people with ADRD. Design. Researchers used dementia attitudes scale (DAS) and interpretive phenomenological analysis (IPA) to analyze participants' attitudes. Setting...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26713169/driving-competence-in-mild-dementia-with-lewy-bodies-in-search-of-cognitive-predictors-using-driving-simulation
#13
Stephanie Yamin, Arne Stinchcombe, Sylvain Gagnon
Driving is a multifactorial behaviour drawing on multiple cognitive, sensory, and physical systems. Dementia is a progressive and degenerative neurological condition that impacts the cognitive processes necessary for safe driving. While a number of studies have examined driving among individuals with Alzheimer's disease, less is known about the impact of Dementia with Lewy Bodies (DLB) on driving safety. The present study compared simulated driving performance of 15 older drivers with mild DLB with that of 21 neurologically healthy control drivers...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26664821/alzheimer-s-disease-exploring-the-role-of-inflammation-and-implications-for-treatment
#14
REVIEW
Mark E McCaulley, Kira A Grush
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by both structural abnormalities and inflammation in the brain. While recent research has chiefly focused on the structural changes involved in AD, understanding the pathophysiology and associated inflammation of the AD brain helps to elucidate potential therapeutic and preventative options. By exploring the data supporting an inflammatory etiology of AD, we present a case for the use of existing evidence-based treatments addressing inflammation as promising options for treating and preventing AD...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26600964/pet-imaging-of-epigenetic-influences-on-alzheimer-s-disease
#15
REVIEW
Paul J Couto, Richard M Millis
The precise role of environment-gene interactions (epigenetics) in the development and progression of Alzheimer's disease (AD) is unclear. This review focuses on the premise that radiotracer-specific PET imaging allows clinicians to visualize epigenetically influenced events and that such imaging may provide new, valuable insights for preventing, diagnosing, and treating AD. Current understanding of the role of epigenetics in AD and the principles underlying the use of PET radiotracers for in vivo diagnosis are reviewed...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26351614/vitamin-d-and-alzheimer-s-disease-neurocognition-to-therapeutics
#16
REVIEW
Anindita Banerjee, Vineet Kumar Khemka, Anirban Ganguly, Debashree Roy, Upasana Ganguly, Sasanka Chakrabarti
Alzheimer's disease (AD), the major cause of dementia worldwide, is characterized by progressive loss of memory and cognition. The sporadic form of AD accounts for nearly 90% of the patients developing this disease. The last century has witnessed significant research to identify various mechanisms and risk factors contributing to the complex etiopathogenesis of AD by analyzing postmortem AD brains and experimenting with animal and cell culture based models. However, the treatment strategies, as of now, are only symptomatic...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26257978/evaluating-adult-s-competency-application-of-the-competency-assessment-process
#17
Dominique Giroux, Sylvie Tétreault, Marie-Pier Landry
Competency assessment of adults with cognitive impairment or mental illness is a complex process that can have significant consequences for their rights. Some models put forth in the scientific literature have been proposed to guide health and social service professionals with this assessment process, but none of these appear to be complete. A new model, the Competency Assessment Process (CAP), was presented and validated in other studies. This paper adds to this corpus by presenting both the CAP model and the results of a survey given to health and social service professionals on its practical application in their clinical practice...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26171273/auditory-and-visual-cues-for-topic-maintenance-with-persons-who-exhibit-dementia-of-alzheimer-s-type
#18
Amy F Teten, Paul A Dagenais, Mary J Friehe
This study compared the effectiveness of auditory and visual redirections in facilitating topic coherence for persons with Dementia of Alzheimer's Type (DAT). Five persons with moderate stage DAT engaged in conversation with the first author. Three topics related to activities of daily living, recreational activities, food, and grooming, were broached. Each topic was presented three times to each participant: once as a baseline condition, once with auditory redirection to topic, and once with visual redirection to topic...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/25821630/inhibitory-effects-of-sodium-arsenite-and-acacia-honey-on-acetylcholinesterase-in-rats
#19
Aliyu Muhammad, Oyeronke A Odunola, Michael A Gbadegesin, Abdullahi B Sallau, Uche S Ndidi, Mohammed A Ibrahim
This study was conducted to investigate the effect of sodium arsenite and Acacia honey on acetylcholinesterase (AChE) activity and electrolytes in the brain and serum of Wistar rats. Male Wistar albino rats in four groups of five rats each were treated with distilled water, sodium arsenite (5 mg/kg body weight), Acacia honey (20% v/v), and sodium arsenite and Acacia honey, daily for one week. The sodium arsenite and Acacia honey significantly (P < 0.05) decreased AChE activity in the brain with the combined treatment being more potent...
2015: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/25810947/beneficial-effects-of-teucrium-polium-and-metformin-on-diabetes-induced-memory-impairments-and-brain-tissue-oxidative-damage-in-rats
#20
S Mojtaba Mousavi, Saeed Niazmand, Mahmoud Hosseini, Zarha Hassanzadeh, Hamid Reza Sadeghnia, Farzaneh Vafaee, Zakieh Keshavarzi
Objective. The effects of hydroalcoholic extract of Teucrium polium and metformin on diabetes-induced memory impairment and brain tissues oxidative damage were investigated. Methods. The rats were divided into: (1) Control, (2) Diabetic, (3) Diabetic-Extract 100 (Dia-Ext 100), (4) Diabetic-Extract 200 (Dia-Ext 200), (5) Diabetic-Extract 400 (Dia-Ext 400), and (6) Diabetic-Metformin (Dia-Met). Groups 3-6 were treated by 100, 200, and 400 mg/kg of the extract or metformin, respectively, for 6 weeks (orally)...
2015: International Journal of Alzheimer's Disease
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