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International Journal of Alzheimer's Disease

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https://www.readbyqxmd.com/read/30155285/the-effect-of-40-hz-light-therapy-on-amyloid-load-in-patients-with-prodromal-and-clinical-alzheimer-s-disease
#1
Rola Ismail, Allan K Hansen, Peter Parbo, Hans Brændgaard, Hanne Gottrup, David J Brooks, Per Borghammer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. AD pathology is characterized by abnormal aggregation of the proteins amyloid- β (A β ) and hyperphosphorylated tau. No effective disease modifying therapies are currently available. A short-duration intervention with 40 Hz light flicker has been shown to reduce brain A β load in transgenic mice. We aimed to test the effect of a similar short-duration 40 Hz light flicker regime in human AD patients. We utilized a Light Emitting Diode (LED) light bulb with a 40 Hz flicker...
2018: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/30057805/cognitive-assessment-test-validation-of-a-short-cognitive-test-for-the-detection-of-mild-cognitive-disorder
#2
Kelly Estrada-Orozco, Kely Bonilla-Vargas, Francy Cruz, Oscar Mancera, Miguel Ruiz, Laura Alvarez, Rodrigo Pardo, Humberto Arboleda
Introduction: Cognitive disorders are a clinical and research challenge; in particular, the mild cognitive disorder (MiCD) requires diagnostic suspicion and tools with adequate performance for its detection. The objective of this study was the validation of a short cognitive test (CATest) for the detection of MiCD in population of 50 years or more. Methods: A diagnostic accuracy study was assembled and performed in a prospective cohort. A consecutive sample of 200 Colombian subjects who represented the whole spectrum of the condition of interest allowed us to reach the objective...
2018: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/30034864/amyloid-beta-1-42-cross-reactive-antibody-prevalent-in-human-sera-may-contribute-to-intraneuronal-deposition-of-a-beta-p-42
#3
Aristo Vojdani, Elroy Vojdani
Antibodies against many neural antigens are detected in the sera of both patients with Alzheimer's disease (AD) and some healthy individuals. Blood-brain barrier dysfunction could make it possible for brain-reactive autoantibodies to reach the brain, where they can react with amyloid ß peptide (AßP). The origin of these autoreactive antibodies in the blood is unclear. The goals of this study were as follows: (1) to examine the immune reactivity of anti-AßP-42 with 22 neuronal and other associated antigens, some of which are involved in the pathophysiology of AD; (2) to classify antibodies to these 22 different antigens into those that cross-react with AßP-42 and those that do not; (3) to determine whether these antibodies react with BBB proteins, nerve growth factors, and enteric neuronal antigens...
2018: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/29850221/analysis-of-association-of-genetic-markers-in-the-luzp2-and-fbxo40-genes-with-the-normal-variability-in-cognitive-performance-in-the-elderly
#4
Vadim Stepanov, Kseniya Vagaitseva, Anna Bocharova, Andrey Marusin, Valentina Markova, Larisa Minaycheva, Oksana Makeeva
Cognitive performance is an important endophenotype for various neurodegenerative and neuropsychiatric traits. In the present study two genetic variants in the leucine-zipper protein (LUZP2) and the F-box 40 protein (FBXO40) genes, previously reported to be genome-wide significant for Alzheimer's diseases and schizophrenia, were examined for an association with cognitive abilities in normal elderly from the Russian population. Rs1021261 in the LUZP2 and rs3772130 in the FBXO40 were genotyped by multiplex PCR and MALDI-TOF mass spectrometry in a sample of 708 normal elderly subjects tested for cognitive performance using the Montreal Cognitive Assessment (MoCA)...
2018: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/29666700/oil-palm-phenolics-inhibit-the-in-vitro-aggregation-of-%C3%AE-amyloid-peptide-into-oligomeric-complexes
#5
Robert P Weinberg, Vera V Koledova, Hyeari Shin, Jennifer H Park, Yew Ai Tan, Anthony J Sinskey, Ravigadevi Sambanthamurthi, ChoKyun Rha
Alzheimer's disease is a severe neurodegenerative disease characterized by the aggregation of amyloid- β peptide (A β ) into toxic oligomers which activate microglia and astrocytes causing acute neuroinflammation. Multiple studies show that the soluble oligomers of A β 42 are neurotoxic and proinflammatory, whereas the monomers and insoluble fibrils are relatively nontoxic. We show that A β 42 aggregation is inhibited in vitro by oil palm phenolics (OPP), an aqueous extract from the oil palm tree (Elaeis guineensis) ...
2018: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/29359063/seeking-a-new-paradigm-for-alzheimer-s-disease-considering-the-roles-of-inflammation-blood-brain-barrier-dysfunction-and-prion-disease
#6
REVIEW
Mark E McCaulley, Kira A Grush
There is no effective etiologic treatment for Alzheimer's disease, nor is there a prophylactic medication which delays or prevents its onset. The lack of an accurate paradigm is undoubtedly related to the lack of effective means of prophylaxis and treatment. The current paradigm of beta amyloid in Alzheimer's brains causing cognitive dysfunction must be modified. Despite failed clinical trials, research continues into amyloid-oriented treatments. The persistence of the amyloid hypothesis/paradigm is an example of anchoring and representativeness heuristics described by Kahneman and Tversky in their classic 1974 Science paper...
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/29348964/association-between-the-apoe-%C3%AE%C2%B5-4-allele-and-late-onset-alzheimer-s-disease-in-an-ecuadorian-mestizo-population
#7
Stefany Montufar, Cristian Calero, Rodrigo Vinueza, Patricio Correa, Andrea Carrera-Gonzalez, Franklin Villegas, Germania Moreta, Rosario Paredes
Alzheimer's disease (AD) is the most common neurodegenerative disease. It has two main pathological hallmarks: amyloid plaques and neurofibrillary tangles. The APOE ε 4 allele has been recognized as the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD) in several populations worldwide, yet the risk varies by region and ethnicity. The aims of this study were to describe APOE allele and genotype frequencies and examine the relationship between the APOE ε 4 allele and LOAD risk in an Ecuadorian Mestizo population...
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/29333315/early-contextual-fear-memory-deficits-in-a-double-transgenic-amyloid-%C3%AE-precursor-protein-presenilin-2-mouse-model-of-alzheimer-s-disease
#8
Yasushi Kishimoto, Kai Fukumoto, Mika Nagai, Ayaka Mizuguchi, Yuiko Kobashi
Presenilin 1 and presenilin 2 (PS1 and PS2) play a critical role in γ -secretase-mediated cleavage of amyloid- β precursor protein (APP) and the subsequent generation of β -amyloid peptides. The purpose of the present study was to test whether PS2 mutation accelerates the onset of contextual fear memory deficits in a mouse model of AD that expresses a mutation (K670N/M671L) of the human APP with the Swedish mutation (Tg2576 mice). In the present study, an APP/PS2 double-transgenic mouse model (PS2Tg2576) was generated by crossbreeding transgenic mice carrying the human mutant PS2 (N141I) with Tg2576 mice...
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/28573062/regional-cerebral-blood-flow-in-mild-cognitive-impairment-and-alzheimer-s-disease-measured-with-arterial-spin-labeling-magnetic-resonance-imaging
#9
REVIEW
Alba Sierra-Marcos
Alzheimer's disease (AD) depicts dynamic changes in regional brain function from early stages of the disease. Arterial spin labeling- (ASL-) based MRI methods have been applied for detecting regional cerebral blood flow (rCBF) perfusion changes in patients with AD and mild cognitive impairment (MCI). Nevertheless, the results obtained from ASL studies in AD and MCI are still controversial, since rCBF maps may show both hypoperfusion or hyperperfusion areas in brain structures involved in different cognitive functions...
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/28567323/comparative-neuroprotective-effects-of-dietary-curcumin-and-solid-lipid-curcumin-particles-in-cultured-mouse-neuroblastoma-cells-after-exposure-to-a%C3%AE-42
#10
Panchanan Maiti, Gary L Dunbar
Aggregation of amyloid beta protein (Aβ) and phosphorylated tau (p-Tau) plays critical roles in pathogenesis of Alzheimer's disease (AD). As an antiamyloid natural polyphenol, curcumin (Cur) has a potential role in prevention of neurodegeneration in AD. However, due to limited absorption of the dietary Cur, the solid lipid Cur particles (SLCP) have been suggested as being more effective for AD therapy. In the present study, we compared the role of dietary Cur and SLCP on oxidative stress, neuronal death, p-Tau level, and certain cell survival markers in vitro, after exposure to Aβ42...
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/28484660/major-depressive-symptoms-increase-3-year-mortality-rate-in-patients-with-mild-dementia
#11
Jindong Ding Petersen, Frans Boch Waldorff, Volkert Dirk Siersma, Thien Kieu Thi Phung, Anna Carina Klara Magdalena Bebe, Gunhild Waldemar
Depression and dementia are commonly concurrent and are both associated with increased mortality among older people. However, little is known about whether home-dwelling patients newly diagnosed with mild dementia coexisting with depressive symptoms have excess mortality. We conducted a post hoc analysis based on data from the Danish Alzheimer's Intervention Study of 330 individuals who were diagnosed with mild dementia within the past 12 months. Thirty-four patients were identified with major depressive symptoms (MD-S) at baseline...
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/28469949/corrigendum-to-alzheimer-s-disease-dementia-as-the-diagnosis-best-supported-by-the-cerebrospinal-fluid-biomarkers-difference-in-cut-off-levels-from-thai-experience
#12
Vorapun Senanarong, Nobdham Sivasariyanonda, Leatchai Wachirutmanggur, Niphon Poungvarin, Chatchawan Rattanabannakit, Nuttapol Aoonkaew, Suthipol Udompunthurak
[This corrects the article DOI: 10.1155/2012/212063.].
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/28255496/diagnostic-accuracy-of-the-overlapping-infinity-loops-wire-cube-and-clock-drawing-tests-for-cognitive-impairment-in-mild-cognitive-impairment-and-dementia
#13
Thammanard Charernboon
Purpose. To investigate the diagnostic accuracy of the overlapping infinity loops, wire cube, and clock drawing tests (CDT) in the detection of mild cognitive impairment (MCI) and dementia. Method. The participants were 60 normal controls (NC), 35 patients with MCI, and 47 patients with mild dementia. Results. The results illustrate that infinity loops, cube, or CDT were not able to discriminate between NC and MCI groups. In dementia detection, the CDT had the highest diagnostic accuracy (sensitivity 76.6% and specificity 87...
2017: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/28083154/assessment-of-health-related-quality-of-life-for-caregivers-of-alzheimer-s-disease-patients
#14
Maria I Andreakou, Angelos A Papadopoulos, Demosthenes B Panagiotakos, Dimitris Niakas
Background. Alzheimer's disease (AD) dementia is a chronic neurodegenerative disorder that results in total cognitive impairment and functional decline. Family members are the most usual caregivers worldwide, resulting in a subsequent degradation of their quality of life. Methods. During November 2013-March 2014 in Athens, Greece, 155 AD patients' family caregivers' Health-Related Quality of Life and existence of depressive symptomatology were assessed. Results. A strong negative correlation between the dimensions of HRQoL and the scores of the depression scale was revealed...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27774333/comparing-cognitive-profiles-of-licensed-drivers-with-mild-alzheimer-s-disease-and-mild-dementia-with-lewy-bodies
#15
Stephanie Yamin, Arne Stinchcombe, Sylvain Gagnon
Purpose. Alzheimer's disease (AD) and dementia with Lewy Bodies (DLB) constitute two of the most common forms of dementia in North America. Driving is a primary means of mobility among older adults and the risk of dementia increases with advanced age. The purpose of this paper is to describe the cognitive profile of licensed drivers with mild AD and mild DLB. Method. Licensed drivers with mild AD, mild DLB, and healthy controls completed neuropsychological tests measuring general cognition, attention, visuospatial/perception, language, and cognitive fluctuations...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27672476/expression-of-phenotypic-astrocyte-marker-is-increased-in-a-transgenic-mouse-model-of-alzheimer-s-disease-versus-age-matched-controls-a-presymptomatic-stage-study
#16
Aurélie Doméné, Chelsea Cavanagh, Guylène Page, Sylvie Bodard, Christophe Klein, Cécile Delarasse, Sylvie Chalon, Slavica Krantic
Recent mouse studies of the presymptomatic stage of Alzheimer's disease (AD) have suggested that proinflammatory changes, such as glial activation and cytokine induction, may occur already at this early stage through unknown mechanisms. Because TNFα contributes to increased Aβ production from the Aβ precursor protein (APP), we assessed a putative correlation between APP/Aβ and TNFα during the presymptomatic stage as well as early astrocyte activation in the hippocampus of 3-month-old APPswe/PS1dE9 mice...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27478677/the-acceptability-and-usefulness-of-cognitive-stimulation-therapy-for-older-adults-with-dementia-a-narrative-review
#17
REVIEW
Hui Moon Toh, Shazli Ezzat Ghazali, Ponnusamy Subramaniam
Cognitive stimulation therapy (CST) is an evidence-based therapy for individuals with mild-to-moderate dementia. Past reviews have only synthesized outcomes obtained through quantitative study which does not fully represent the understanding on the acceptability and usefulness of CST. Therefore, the present review aims to integrate outcomes obtained from both quantitative and qualitative studies to provide a deeper understanding on the acceptability and usefulness of CST for older adults with dementia. Findings of literature were retrieved from searches of computerized databases in relation to CST for people with dementia...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27413574/family-dynamics-and-personal-strengths-among-dementia-caregivers-in-argentina
#18
Aaliah G Elnasseh, Michael A Trujillo, Silvina Victoria Peralta, Miriam E Stolfi, Eliana Morelli, Paul B Perrin, Juan Carlos Arango-Lasprilla
This study examined whether healthier family dynamics were associated with higher personal strengths of resilience, sense of coherence, and optimism among dementia caregivers in Argentina. Caregivers are usually required to assist individuals with dementia, and family members have typically fulfilled that role. Personal strengths such as resilience, sense of coherence, and optimism have been shown to protect caregivers from some of the negative experiences of providing care, though the family-related variables associated with these personal strengths are largely unknown...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/27213078/nanoscale-extracellular-vesicle-analysis-in-alzheimer-s-disease-diagnosis-and-therapy
#19
REVIEW
Pete Heinzelman, Tina Bilousova, Jesus Campagna, Varghese John
Diagnostic assays that leverage bloodborne neuron-derived (neuronal) nanoscale extracellular vesicles (nsEVs) as "windows into the brain" can predict incidence of Alzheimer's Disease (AD) many years prior to onset. Beyond diagnostics, bloodborne neuronal nsEVs analysis may have substantial translational impact by revealing mechanisms of AD pathology; such knowledge could enlighten new drug targets and lead to new therapeutic approaches. The potential to establish three-dimensional nsEV analysis methods that characterize highly purified bloodborne nsEV populations in method of enrichment, cell type origin, and protein or RNA abundance dimensions could bring this promise to bear by yielding nsEV "omics" datasets that uncover new AD biomarkers and enable AD therapeutic development...
2016: International Journal of Alzheimer's Disease
https://www.readbyqxmd.com/read/26977333/medical-students-perceptions-of-dementia-after-participation-in-poetry-workshop-with-people-with-dementia
#20
Alaina J Garrie, Shruti Goel, Martin M Forsberg
Purpose. Researchers assessed whether medical students' participation in a poetry workshop with people with Alzheimer's disease and related dementias (ADRD) affected their attitudes towards persons with ADRD. Objective. To add to the growing body of research summarizing the impact of nonclinical interventions on medical students' perspectives about people with ADRD. Design. Researchers used dementia attitudes scale (DAS) and interpretive phenomenological analysis (IPA) to analyze participants' attitudes. Setting...
2016: International Journal of Alzheimer's Disease
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