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Journal of Ophthalmology

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https://www.readbyqxmd.com/read/28928984/rho-kinase-in-eye-disease
#1
EDITORIAL
Naoki Okumura, Shintaro Nakao, Toshihiro Inoue, Padmanabhan Pattabiraman
No abstract text is available yet for this article.
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28928983/influences-of-27-gauge-vitrectomy-on-corneal-topographic-conditions
#2
Takafumi Hirashima, Takao Utsumi, Miou Hirose, Hideyasu Oh
PURPOSE: To evaluate the influences of 27-gauge vitrectomy on corneal topographic conditions. METHOD: Fifty-six eyes of 56 patients undergoing 27-gauge vitrectomy were retrospectively studied. Twenty-three eyes with epiretinal membrane (ERM), 23 eyes with macular hole (MH), and 10 eyes with proliferative diabetic retinopathy (PDR) were included. Forty-five of the 56 eyes underwent 27-gauge phacovitrectomy (group 1), and the remaining 11 eyes underwent 27-gauge vitrectomy alone (group 2)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28928982/corneal-spherical-aberration-and-corneal-asphericity-after-small-incision-lenticule-extraction-and-femtosecond-laser-assisted-lasik
#3
Hui Zhang, Yan Wang, Hua Li
PURPOSE: To investigate corneal spherical aberration and corneal asphericity after small incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK). METHODS: This study enrolled 70 patients having SMILE and 64 subjects receiving FS-LASIK. The preoperative spherical equivalent (SE) was -5.83 ± 1.23 diopters (D) and -6.20 ± 1.52 D, respectively. The uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), SE, corneal spherical aberration, and asphericity over the 6...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28928981/association-of-neovascular-glaucoma-with-risk-of-stroke-a-population-based-cohort-study
#4
Cheng-Wen Su, Yue-Cune Chang, Cheng-Li Lin, Hsin-Yi Chen
Neovascular glaucoma (NVG), caused by ocular ischemia, is a serious ocular disease complicated by intractably increased intraocular pressure. Cerebrovascular accidents are classified into ischemic and hemorrhagic stroke. Based on the similar pathogenic mechanisms of NVG and ischemic stroke, we investigated the relationship between NVG and stroke by using a nationally representative sample. This study included 416 NVG patients and 4160 controls. Medical comorbidities were also evaluated. The cumulative incidence of ischemic stroke was 15...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28912968/bimanual-microincision-cataract-surgery-versus-coaxial-microincision-cataract-surgery-a-meta-analysis-of-randomized-controlled-trials-and-cohort-studies
#5
Chenxi Fu, Naipin Chu, Xiaoning Yu, Ke Yao
PURPOSE: This meta-analysis was conducted to compare the intraoperative and postoperative outcomes of bimanual microincision cataract surgery (B-MICS) and coaxial microincision cataract surgery (C-MICS). METHODS: Three databases were searched for papers that compared B-MICS and C-MICS from inception to June 2016. The following intraoperative and postoperative outcomes were included in the final meta-analysis: ultrasound time (UST), effective phacoemulsification time (EPT), balanced salt solution use (BSS use), mean surgery time, best-corrected visual acuity (BCVA), central corneal thickness (CCT), and increased CCT...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28912967/correlation-of-macular-focal-electroretinogram-with-ellipsoid-zone-extension-in-stargardt-disease
#6
Edoardo Abed, Giorgio Placidi, Luigi Calandriello, Marco Piccardi, Francesca Campagna, Matteo Bertelli, Angelo Maria Minnella, Maria Cristina Savastano, Benedetto Falsini
Stargardt disease (STGD1) is the most common cause of inherited juvenile macular degeneration. This disease is characterized by a progressive accumulation of lipofuscin in the outer retina and subsequent loss of photoreceptors and retinal pigment epithelium. The aim of this study was to evaluate the relationship between cone photoreceptor function and structure in STGD1. Macular function was assessed by visual acuity measurement and focal electroretinogram (FERG) recording while spectral domain optical coherence tomography (SD-OCT) imaging was performed to evaluate the integrity of photoreceptors...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28912966/abcc6-gene-analysis-in-20-japanese-patients-with-angioid-streaks-revealing-four-frequent-and-two-novel-variants-and-pseudodominant-inheritance
#7
Satoshi Katagiri, Yuya Negishi, Kei Mizobuchi, Mitsuyoshi Urashima, Tadashi Nakano, Takaaki Hayashi
PURPOSE: To report the spectrum of ABCC6 variants in Japanese patients with angioid streaks (AS). PATIENTS AND METHODS: This was a single-center cohort study. The medical records of 20 patients with AS from 18 unrelated Japanese families were retrospectively reviewed. Screening of the ABCC6 gene (exons 1 to 31) was performed using PCR-based Sanger sequencing. RESULTS: Eight ABCC6 variants were identified as candidate disease-causing variants...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28900544/effect-of-spherical-aberration-on-the-optical-quality-after-implantation-of-two-different-aspherical-intraocular-lenses
#8
Michael Lasta, Kata Miháltz, Illés Kovács, Pia Veronika Vécsei-Marlovits
PURPOSE: To compare the effect of spherical aberration on optical quality in eyes with two different aspherical intraocular lenses. METHODS: 120 eyes of 60 patients underwent phacoemulsification. In patients' eyes, an aberration-free IOL (Aspira-aA; Human Optics) or an aberration-correcting aspherical IOL (Tecnis ZCB00; Abott Medical Optics) was randomly implanted. After surgery, contrast sensitivity and wavefront measurements as well as tilt and decentration measurements were performed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28900543/switching-to-aflibercept-in-diabetic-macular-edema-not-responding-to-ranibizumab-and-or-intravitreal-dexamethasone-implant
#9
Antoine Herbaut, Franck Fajnkuchen, Lise Qu-Knafo, Sylvia Nghiem-Buffet, Bahram Bodaghi, Audrey Giocanti-Auregan
PURPOSE: To assess short-term functional and anatomical outcomes of refractory diabetic macular edema (DME) following a switch from ranibizumab or dexamethasone to aflibercept. METHODS: We included retrospectively eyes with persistent DME after at least 3 ranibizumab and/or one dexamethasone implant intravitreal injections (IVI). The primary endpoint was the mean change in visual acuity (VA) at month 6 (M6) after switching. RESULTS: Twenty-five eyes were included...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28894607/evaluation-of-cholinergic-deficiency-in-preclinical-alzheimer-s-disease-using-pupillometry
#10
Shaun Frost, Liam Robinson, Christopher C Rowe, David Ames, Colin L Masters, Kevin Taddei, Stephanie R Rainey-Smith, Ralph N Martins, Yogesan Kanagasingam
Cortical cholinergic deficiency is prominent in Alzheimer's disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye. Pupillometry is a low-cost, noninvasive technique that may be useful for monitoring cholinergic deficits which generally lead to memory and cognitive disorders. The aim of the study was to evaluate pupillometry for early detection of AD by comparing the pupil flash response (PFR) in AD (N = 14) and cognitively normal healthy control (HC, N = 115) participants, with the HC group stratified according to high (N = 38) and low (N = 77) neocortical amyloid burden (NAB)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28894606/corneal-nerve-regeneration-after-self-retained-cryopreserved-amniotic-membrane-in-dry-eye-disease
#11
Thomas John, Sean Tighe, Hosam Sheha, Pedram Hamrah, Zeina M Salem, Anny M S Cheng, Ming X Wang, Nathan D Rock
PURPOSE: To evaluate the efficacy of self-retained cryopreserved amniotic membrane (CAM) in promoting corneal nerve regeneration and improving corneal sensitivity in dry eye disease (DED). METHODS: In this prospective randomized clinical trial, subjects with DED were randomized to receive CAM (study group) or conventional maximum treatment (control). Changes in signs and symptoms, corneal sensitivity, topography, and in vivo confocal microscopy (IVCM) were evaluated at baseline, 1 month, and 3 months...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28884025/the-pattern-of-retinal-nerve-fiber-layer-and-macular-ganglion-cell-inner-plexiform-layer-thickness-changes-in-glaucoma
#12
Jin A Choi, Hye-Young Shin, Hae-Young Lopilly Park, Chan Kee Park
BACKGROUND/AIMS: To investigate the patterns of retinal ganglion cell damage at different stages of glaucoma, using the circumpapillary retinal nerve fiber layer (RNFL) and macula ganglion cell-inner plexiform layer (GCIPL) thicknesses. METHODS: In 296 eyes of 296 glaucoma patients and 55 eyes of 55 healthy controls, the correlations of mean deviation (MD) with the superior and inferior quadrant RNFL/GCIPL thickness (defined as the average of three superior and inferior sectors, resp...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28884024/combined-phacoemulsification-and-intravitreal-dexamethasone-implant-ozurdex%C3%A2-in-diabetic-patients-with-coexisting-cataract-and-diabetic-macular-edema
#13
Claudio Furino, Francesco Boscia, Alfredo Niro, Ermete Giancipoli, Maria Oliva Grassi, Giuseppe D'amico Ricci, Francesco Blasetti, Michele Reibaldi, Giovanni Alessio
PURPOSE: To investigate the effectiveness and safety of combined phacoemulsification and dexamethasone intravitreal implant in patients with cataract and diabetic macular edema. METHODS: In this two-center, retrospective, single-group study, the charts of 16 consecutive patients who underwent combined phacoemulsification and intravitreal dexamethasone implant were retrospectively reviewed. These 16 patients, 7 men and 9 women, were observed at least 3 months of follow-up...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28884023/clinical-features-and-visual-acuity-outcomes-in-culture-positive-endogenous-fungal-endophthalmitis-in-southern-china
#14
Fang Duan, Yao Yang, Zhaohui Yuan, Yongxin Zheng, Zhixing Cheng, Xiaofeng Lin
PURPOSE: To report the causative organisms, management strategies, and visual outcomes of culture-proven endogenous fungal endophthalmitis in a case series from southern China. METHODS: We reviewed the microbiological and medical records of patients with culture-positive endogenous fungal endophthalmitis visiting the Zhongshan Ophthalmic Center, Guangzhou, China, between January 1, 2006, and March 31, 2016. RESULTS: The inclusion criteria were met in 32 eyes of 29 patients...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28848678/prpf3-associated-autosomal-dominant-retinitis-pigmentosa-and-cyp4v2-associated-bietti-s-crystalline-corneoretinal-dystrophy-coexist-in-a-multigenerational-chinese-family
#15
Xiaohong Meng, Qiyou Li, Hong Guo, Haiwei Xu, Shiying Li, Zhengqin Yin
PURPOSE: To characterize the clinical and molecular genetic characteristics of a large, multigenerational Chinese family showing different phenotypes. METHODS: A pedigree consisted of 56 individuals in 5 generations was recruited. Comprehensive ophthalmic examinations were performed in 16 family members affected. Mutation screening of CYP4V2 was performed by Sanger sequencing. Next-generation sequencing (NGS) was performed to capture and sequence all exons of 47 known retinal dystrophy-associated genes in two affected family members who had no mutations in CYP4V2...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28848677/a-critical-analysis-of-the-available-in-vitro-and-ex-vivo-methods-to-study-retinal-angiogenesis
#16
REVIEW
A F Moleiro, G Conceição, A F Leite-Moreira, A Rocha-Sousa
Angiogenesis is a biological process with a central role in retinal diseases. The choice of the ideal method to study angiogenesis, particularly in the retina, remains a problem. Angiogenesis can be assessed through in vitro and in vivo studies. In spite of inherent limitations, in vitro studies are faster, easier to perform and quantify, and typically less expensive and allow the study of isolated angiogenesis steps. We performed a systematic review of PubMed searching for original articles that applied in vitro or ex vivo angiogenic retinal assays until May 2017, presenting the available assays and discussing their applicability, advantages, and disadvantages...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28845305/optical-coherence-tomography-observation-of-gonio-structures-during-microhook-ab-interno-trabeculotomy
#17
Masaki Tanito
INTRODUCTION: Intraoperative observation of ocular structures using microscope-integrated optical coherence tomography (iOCT) has been adopted recently. I report my initial feasibility assessment of iOCT for the incised trabecular meshwork observation during microhook ab interno trabeculotomy. CASE SERIES: Both the nasal and temporal sides or either side of the trabecular meshwork/inner wall of Schlemm's canal was incised more than 3 clock hours. After then, under observation using a Swan-Jacob gonioprism lens with the real-time 5-line scan mode, OCT images of the area were successfully acquired in 10 (83%) of 12 sides in nine eyes...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28845304/double-internal-limiting-membrane-insertion-for-macular-hole-associated-retinal-detachment
#18
San-Ni Chen, Chung-May Yang
PURPOSE: To describe a modified technique of internal limiting membrane (ILM) insertion for macular hole- (MH-) associated retinal detachment (RD) in highly myopic eyes. METHODS: Nine eyes underwent pars plana vitrectomy, cortical vitreous removal, and fovea-sparing ILM peeling. Double ILM insertion into the hole was performed with inverted perifoveal ILM and a free ILM flap followed by air-fluid exchange. RESULTS: Two of the 9 eyes had perifoveal ILM partially torn after cortical vitreous or epiretinal removal...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28845303/use-of-5-fluorouracil-soaked-bioamniotic-membranes-in-trabeculectomy-for-primary-open-angle-glaucoma-a-retrospective-analysis
#19
Chenming Zhang, Min Wu, Jianrong Wang, Miaomiao Zhang, Xu Wang, Wei Liu
The study is a retrospective analysis of 51 patients (76 eyes) with primary open-angle glaucoma (POAG) who admitted to our hospital from 2008 to 2010 to analyze the efficacy of trabeculectomy in combination with 5-fluorouracil- (5-FU-) soaked amniotic membranes for the treatment of POAG patients. Among them, 30 patients (41 eyes) were treated with trabeculectomy in combination with 5-FU-soaked amniotic membrane and 21 patients (35 eyes) were treated with trabeculectomy in combination with MMC. Preoperative and postoperative intraocular pressures (IOP), cup/disc ratio, visual acuity and postoperative macular OCT, complications, treatment, and number of corneal endothelial cells were measured, recorded, and analyzed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28840039/outcomes-of-vitrectomy-in-pediatric-retinal-detachment-with-proliferative-vitreoretinopathy
#20
Robert Rejdak, Dominika Nowakowska, Katarzyna Wrona, Ryszard Maciejewski, Anselm G Junemann, Katarzyna Nowomiejska
AIM: To report outcomes of pars plana vitrectomy (PPV) in pediatric retinal detachment (RD) with proliferative vitreoretinopathy (PVR), complications, factors influencing the final anatomical and functional results. METHODS: Retrospective consecutive case series of 14 eyes. Average postoperative follow-up period was 34 months. RESULTS: Mean age of patients was 10 years; eleven patients (79%) were males. The most common etiology was trauma (57%), the second-myopia (36%) and one case of uveitis (7%)...
2017: Journal of Ophthalmology
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