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Journal of Ophthalmology

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https://www.readbyqxmd.com/read/28428895/suppression-of-retinal-neovascularization-by-inhibition-of-galectin-1-in-a-murine-model-of-oxygen-induced-retinopathy
#1
Ning Yang, Wenxi Zhang, Tao He, Yiqiao Xing
Galectin-1 (Gal-1) has been proved to be an important factor in the process of tumor angiogenesis recently. As a small molecule, OTX008 serves as a selective inhibitor of Gal-1. In this study, the role of Gal-1 and the antiangiogenic effect of OTX008 on retinal neovascularization (RNV) were investigated using a mouse model of oxygen-induced retinopathy. The outcome indicated that Gal-1 was overexpressed and closely related to retinal neovessels in OIR. After intravitreal injection of OTX008 at P12, the RNV was significantly reduced at P17, measuring by cross-sectional H&E staining and whole-mount fluorescence...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28428894/the-protective-role-of-hyaluronic-acid-in-cr-vi-induced-oxidative-damage-in-corneal-epithelial-cells
#2
Wei Wu, Hua Jiang, Xinnian Guo, Yu Wang, Shibo Ying, Lingfang Feng, Tao Li, Hailing Xia, Yixiao Zhang, Riping Chen, Tianhui Chen, Jianlin Lou
Cr(VI) exposure could produce kinds of intermediates and reactive oxygen species, both of which were related to DNA damage. Hyaluronan (HA) has impressive biological functions and was reported to protect corneal epithelial cells against oxidative damage induced by ultraviolet B, benzalkonium chloride, and sodium lauryl sulfate. So the aim of our study was to investigate HA protection on human corneal epithelial (HCE) cells against Cr(VI)-induced toxic effects. The HCE cell lines were exposed to different concentrations of K2Cr2O7 (1...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28424747/association-between-optic-nerve-head-microcirculation-and-macular-ganglion-cell-complex-thickness-in-eyes-with-untreated-normal-tension-glaucoma-and-a-hemifield-defect
#3
Ayako Anraku, Kyoko Ishida, Nobuko Enomoto, Seiji Takagi, Hiroyuki Ito, Asuka Takeyama, Fumihiko Yagi, Goji Tomita
Purpose. We evaluated the association between optic nerve head (ONH) microcirculation and macular ganglion cell complex (mGCC) thickness in patients with untreated normal tension glaucoma (NTG) and a hemifield defect. Methods. The medical records of 47 patients with untreated NTG were retrospectively reviewed. Laser speckle flowgraphy was used to obtain mean blur rate (MBR), a relative measure of blood flow. Average total deviation (TD), mGCC, and the circumpapillary retinal nerve fiber layer (cpRNFL) thickness were also analyzed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28421140/comparison-of-corneal-power-and-astigmatism-between-simulated-keratometry-true-net-power-and-total-corneal-refractive-power-before-and-after-smile-surgery
#4
Yishan Qian, Yan Liu, Xingtao Zhou, Rajeev Krishnan Naidu
Purpose. To compare the mean corneal power (Km) and total astigmatism (Ka) estimated by three methods: simulated keratometry (simK), true net power (TNP), and total corneal refractive power (TCRP) before and after femtosecond laser small incision lenticule extraction (SMILE) surgery. Methods. A retrospective, cross-sectional study. SimK, TNP, and TCRP from a Scheimpflug analyzer were obtained from 144 patients before and 6 months after SMILE surgery. Km and Ka were recorded as the mean of individual paracentral rings of 1...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28421139/regional-relationship-between-macular-retinal-thickness-and-corresponding-central-visual-field-sensitivity-in-glaucoma-patients
#5
Chun-Hsiu Liu, Shirley H L Chang, Shiu-Chen Wu
Purpose. To investigate the relationship between macular retinal thickness (MRT) and central visual field sensitivity (VFS) in patients with glaucoma. Methods. This retrospective study enrolled patients diagnosed with open-angle glaucoma. All study patients underwent Humphrey 10-2 visual field (VF) test and Spectralis spectral-domain optical coherence tomography (SD-OCT) exam for MRT measurement. Results. Sixty-eight eyes of 68 patients were examined. The correlation coefficients between VFS and MRT were 0...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28409025/the-impact-of-the-menstrual-cycle-on-perioperative-bleeding-in-vitreoretinal-surgery
#6
Zhong Lin, Nived Moonasar, Rong Han Wu, Robin R Seemongal-Dass
Purpose. To investigate the effect of menstrual cycle on perioperative bleeding of primary vitreoretinal surgery. Methods. Data on female patients who had vitrectomy surgery was retrospectively collected. Exclusion criteria were history of trauma, vitreous hemorrhage, previous vitreoretinal surgery, diabetic retinopathy, endophthalmitis, acute retinal necrosis, single vitreous opacity, and use of antiplatelet agents. Perioperative bleeding was defined as hemorrhage in the iris, vitreous, choroidal, retina, or subretina during surgery or up to one day postoperatively...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28409024/response-to-comment-on-exotropia-is-the-main-pattern-of-childhood-strabismus-surgery-in-the-south-of-china-a-six-year-clinical-review
#7
COMMENT
Xinping Yu, Zhouduo Ji, Huanyun Yu, Meiping Xu, Jinling Xu
No abstract text is available yet for this article.
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28409023/a-new-sutureless-illuminated-macular-buckle-designed-for-myopic-macular-hole-retinal-detachment
#8
Ahmed M Bedda, Ahmed M Abdel Hadi, Mohamed Lolah, Muhammad S Abd Al Shafy
Purpose. To report the anatomic and visual results of a new sutureless illuminated macular buckle designed for patients with macular hole retinal detachment related to high myopia (MMHRD). Design. Prospective nonrandomized comparative interventional trial. Methods. Twenty myopic eyes of 20 patients (mean age, 51.4 years; range, 35-65 years) presenting with MMHRD with a posterior staphyloma, in whom the new buckle was used, were evaluated. The buckle used was assembled from a 5 mm wide sponge and a 7 mm wide silicone tire; it was fixed utilizing the sterile topical adhesive Histoacryl Blue (B Braun, TS1050044FP) which polymerizes in seconds upon being exposed to water-containing substances...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28409022/the-safety-and-efficacy-of-adjustable-postoperative-position-after-pars-plana-vitrectomy-for-rhegmatogenous-retinal-detachment
#9
Zhong Lin, Jin Tao Sun, Rong Han Wu, Nived Moonasar, Ye Hui Zhou
Purpose. To report the safety and efficacy of adjustable postoperative position for rhegmatogenous retinal detachment (RRD). Methods. Retrospective review of 536 consecutive RRD eyes that underwent vitrectomy surgery for retina repair from year 2008 to 2014. The retinal breaks were divided into superior, lateral (nasal, temporal, and macular), and inferior locations, according to the clock of breaks. Patients with superior and lateral break location were allowed to have facedown position or lateral decubitus position postoperatively, while patients with inferior break location were allowed to have facedown position...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28409021/tissue-distribution-of-trans-resveratrol-and-its-metabolites-after-oral-administration-in-human-eyes
#10
Shuaishuai Wang, Zheng Wang, Shuo Yang, Tiemei Yin, Yaoli Zhang, Yuanjun Qin, Robert N Weinreb, Xufang Sun
Purpose. This study was performed to measure the concentration of trans-resveratrol and its three metabolites in human eyes. Methods. The patients who underwent pars plana vitrectomy for rhegmatogenous retinal detachment were included. The participants were orally given trans-resveratrol-based supplement (Longevinex®). A suitable amount of conjunctiva, aqueous humor, and vitreous humor were obtained during the operation. High-performance liquid chromatography (HPLC) with mass spectrometry (LC/MS/MS) was used to detect the concentration of trans-resveratrol and its three metabolites in the various samples...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28396804/impact-of-treatment-decentration-on-higher-order-aberrations-after-smile
#11
Ying Yu, Wenwen Zhang, Xinliang Cheng, Jianru Cai, Hui Chen
Purpose. To evaluate decentration following femtosecond laser small incision lenticule extraction (SMILE) and sub-Bowman keratomileusis (SBK) and its impact on higher-order aberrations (HOAs). Methods. Prospective, nonrandom, and comparison study. There were 96 eyes of 52 patients who received SMILE and 96 eyes of 49 patients who received SBK in this study. Decentration was calculated 6 months after surgery with Pentacam. HOAs and visual acuity after the surgery were examined for patients in both groups before and 6 months after surgery...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28396803/corneal-clarity-and-visual-outcomes-after-small-incision-lenticule-extraction-and-comparison-to-femtosecond-laser-assisted-in-situ-keratomileusis
#12
Apostolos Lazaridis, Konstantinos Droutsas, Walter Sekundo, Michael Petrak, Stephan Schulze
Purpose. To evaluate corneal clarity and visual outcomes after small-incision lenticule extraction (SMILE) and compare them to femtosecond laser-assisted in situ keratomileusis (FS-LASIK). Materials and Methods. Fifty-eight myopic eyes of 33 patients who underwent SMILE were compared to 58 eyes of 33 patients treated with FS-LASIK. All procedures were performed using VisuMax® femtosecond laser and MEL 80® excimer laser (Carl Zeiss Meditec AG, Germany). Pentacam™ (Oculus, Germany) was used for pre- and 3-month postoperative corneal densitometry (CD) analysis...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28396802/a-portable-inexpensive-nonmydriatic-fundus-camera-based-on-the-raspberry-pi%C3%A2-computer
#13
Bailey Y Shen, Shizuo Mukai
Purpose. Nonmydriatic fundus cameras allow retinal photography without pharmacologic dilation of the pupil. However, currently available nonmydriatic fundus cameras are bulky, not portable, and expensive. Taking advantage of recent advances in mobile technology, we sought to create a nonmydriatic fundus camera that was affordable and could be carried in a white coat pocket. Methods. We built a point-and-shoot prototype camera using a Raspberry Pi computer, an infrared-sensitive camera board, a dual infrared and white light light-emitting diode, a battery, a 5-inch touchscreen liquid crystal display, and a disposable 20-diopter condensing lens...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28392940/pattern-visual-evoked-potential-changes-in-diabetic-patients-without-retinopathy
#14
Ozgur Balta, Gulten Sungur, Mehmet Yakin, Nurten Unlu, Oyku Bezen Balta, Firdevs Ornek
Purpose. To assess the different check sizes of pattern visual evoked potential (PVEP) in diabetic patients without retinopathy according to HbA1c levels and diabetes duration. Methods. Fifty-eight eligible patients with type 2 diabetes mellitus and 26 age- and sex-matched healthy controls were included in the study. Only the right eye of each patient was analyzed. All of the patients underwent a comprehensive ophthalmic examination, and the PVEPs were recorded. Results. There was a statistically significant difference in P100 latency in 1-degree check size and in N135 latency in 2-degree check size between controls and patient groups which have different HbA1c levels...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28392939/thinner-corneas-appear-to-have-more-striking-effects-of-corneal-collagen-crosslinking-in-patients-with-progressive-keratoconus
#15
Yunfei Han, Yanyun Xu, Wei Zhu, Yuling Liu, Zhen Liu, Xiaoxiao Dou, Guoying Mu
Purpose. To analyze the outcomes and difference after UVA/riboflavin corneal collagen crosslinking (CXL) in four different corneal thickness groups of patients with progressive keratoconus. Methods. Retrospective study. Eyes with progressive keratoconus after CXL were divided into 4 subgroups as follows: group 1, thinnest corneal thickness (TCT) ≤ 400 µm; group 2, 400 µm < TCT ≤ 450 µm; group 3, 450 µm < TCT ≤ 500 µm; group 4, TCT ≥ 500 µm. Baseline, 6-month, and 12-month visual acuity, corneal topography, TCT, and endothelial cell density were evaluated...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28392938/effect-of-mitomycin-c-on-myopic-versus-astigmatic-photorefractive-keratectomy
#16
Ashwag A Almosa, Samah M Fawzy
Purpose. Long-term mitomycin C (MMC) effects on photorefractive keratectomy (PRK) were compared in simple myopic and astigmatic patients. Methods. In this observational cohort study, subjects were selected based on preoperative and postoperative data collected from medical records; they were divided into simple myopia with/without MMC and myopic astigmatism with/without MMC groups. Haze, uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), subjective refraction, and K-reading were evaluated at 1-, 3-, 6-, and 12-month follow-ups...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28386477/a-retrospective-study-on-clinical-features-and-visual-outcome-of-patients-hospitalized-for-ocular-trauma-in-cangzhou-china
#17
Xi Zhang, Yuqing Liu, Xiangning Ji, Yuanyuan Zou
Purpose. To describe clinical features and to analyze visual outcome of ocular trauma in Cangzhou in 2012-2015, China. Methods. A retrospective study of ocular trauma cases admitted to Cangzhou Central Hospital from January 2012 till December 2015 was performed. Results. This study included a total of 507 eyes from 478 patients. Four hundred (83.7%) patients were male, with a male-to-female ratio of 5.1 : 1. Mean age was 43.6 ± 18.3 years (5-95 years). The largest age group was 45-59 years old, followed by 30-44 years old, presenting two peaks of the age distribution and accounting for 28...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28386476/new-developments-in-the-classification-pathogenesis-risk-factors-natural-history-and-treatment-of-branch-retinal-vein-occlusion
#18
REVIEW
Jia Li, Yannis M Paulus, Yuanlu Shuai, Wangyi Fang, Qinghuai Liu, Songtao Yuan
For years, branch retinal vein occlusion is still a controversial disease in many aspects. An increasing amount of data is available regarding classification, pathogenesis, risk factors, natural history, and therapy of branch retinal vein occlusion. Some of the conclusions may even change our impression of branch retinal vein occlusion. It will be beneficial for our doctors to get a deeper understanding of this disease and improve the treatment skills. The aims of this review is to collect the information above and report new ideas especially from the past a few years...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28377823/optical-coherence-tomography-and-optical-coherence-tomography-angiography-in-monitoring-coats-disease
#19
Wojciech Hautz, Joanna Gołębiewska, Beata Kocyła-Karczmarewicz
Purpose. The aim of this study was to evaluate the usefulness of optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) in monitoring pediatric patients with Coats' disease. Material and Methods. This retrospective study included 9 Caucasian patients receiving treatment for Coats' disease at the Children's Memorial Health Institute Ophthalmology Department between December 2014 and May 2016. The course of the disease was monitored with OCTA in combination with OCT and fluorescein angiography (FA)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28367324/comparative-study-of-27-gauge-versus-25-gauge-vitrectomy-for-the-treatment-of-primary-rhegmatogenous-retinal-detachment
#20
Stanislao Rizzo, Silvio Polizzi, Francesco Barca, Tomaso Caporossi, Gianni Virgili
Purpose. To compare the vitrectomy time, clinical outcomes, and complications between 27-gauge (27-G) and 25-gauge (25-G) vitrectomy in patients with primary rhegmatogenous retinal detachment (PRRD). Methods. Prospective, nonrandomized, comparative, interventional study. Forty consecutive patients with PRRD were recruited. Twenty patients underwent the 27-gauge procedure and twenty patients had the 25-gauge procedure. The main outcome measure of the study was the actual vitrectomy time. Results. The mean duration of vitreous removal was 23...
2017: Journal of Ophthalmology
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