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Journal of Ophthalmology

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https://www.readbyqxmd.com/read/30002924/psychological-aspects-and-depression-in-patients-with-symptomatic-keratoconus
#1
Marilita M Moschos, Nikolaos S Gouliopoulos, Chris Kalogeropoulos, Sofia Androudi, George Kitsos, Dimitrios Ladas, Michael Tsatsos, Irini Chatziralli
Purpose: To assess the psychological status of keratoconus sufferers and to determine the relationship between depression and visual impairment in this group of patients. Methods: Fifty-six patients with keratoconus and forty-seven age- and gender-matched healthy control subjects were retroprospectively analyzed. Every participant underwent a complete ophthalmological examination. Keratoconus diagnosis was confirmed with corneal topography and tomography. Zung Depression Inventory Questionnaire and Patient Health Questionnaire-9 (PHQ-9) were completed by everyone...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29977615/association-of-genes-in-the-high-density-lipoprotein-metabolic-pathway-with-polypoidal-choroidal-vasculopathy-in-asian-population-a-systematic-review-and-meta-analysis
#2
REVIEW
Ming-Zhen Yuan, Ruo-An Han, Chen-Xi Zhang, You-Xin Chen
Purpose: To assess the association of genes in the high-density lipoprotein metabolic pathway (HDLMP) with polypoidal choroidal vasculopathy (PCV) and the genetic difference in the HDLMP between PCV and age-related macular degeneration (AMD). Methods: We performed a literature search in EMBASE, PubMed, and Web of Science for genetic studies on 7 single nucleotide polymorphisms (SNPs) from 5 genes in the HDLMP including cholesteryl ester transfer protein (CETP), hepatic lipase (LIPC), lipoprotein lipase (LPL), ATP-binding cassette transporter A1 (ABCA1), and ATP-binding cassette transporter G1 (ABCG1) in PCV...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29967695/the-effects-of-uncomplicated-cataract-surgery-on-retinal-layer-thickness
#3
Ali Kurt, Raşit Kılıç
Purpose: Our aim was to assess changes in the total retinal thickness (TRT), total retinal volume (TRV), and retinal layer thickness after uncomplicated cataract surgery. Methods: A total of 32 eyes of 32 patients who had undergone uncomplicated phacoemulsification surgery and intraocular lens implantation in one eye were enrolled. Effective phacoemulsification time (EPT) and total energy (TE) were recorded. Thickness and TRV were measured using optical coherence tomography...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29967694/protection-of-corneal-limbus-from-riboflavin-prevents-epithelial-stem-cell-loss-after-collagen-cross-linking
#4
Hyo Kyung Lee, Jin Suk Ryu, Hyun Jeong Jeong, Mee Kum Kim, Joo Youn Oh
Purpose: To investigate whether the protection of corneal limbus from riboflavin exposure during collagen cross-linking (CXL) prevents limbal epithelial stem cell (LESC) loss. Methods: Ten New Zealand white rabbits received an epithelium-off CXL using an accelerated protocol. Seven days before procedure, 5-bromo-2-deoxyuridine (BrdU) was intraperitoneally injected. During procedure, riboflavin was applied to the corneal surface within a 9 mm diameter retention ring in 5 rabbits, thereby preventing the limbus from riboflavin exposure...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29955394/choroidal-thickness-in-chinese-children-aged-8-to-11-years-with-mild-and-moderate-myopia
#5
Ya Qi, Li Li, Fengju Zhang
Purpose: To investigate macular choroidal thickness (CT), topographical variation, and associations between subfoveal choroidal thickness (SFCT) and age, gender, spherical equivalent (SE), and axial length (AL) in Chinese healthy mild and moderate myopia children aged 8 to 11 years. Methods: One hundred twenty eyes from 120 healthy children were studied. Children were divided into mild and moderate myopia groups. AL and CT were evaluated. CTs were measured at the fovea, and 1 mm, 2 mm, and 3 mm nasal, temporal, superior, and inferior to the fovea...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29887992/patient-and-surgeon-satisfaction-levels-after-using-an-acrylic-hydrophobic-monofocal-iol-and-the-malyugin-ring-in-pseudoexfoliation-syndrome-patients
#6
Andreas F Borkenstein, Eva-Maria Borkenstein
Purpose: The purpose of this prospective analysis was to evaluate the patient and surgeon satisfaction levels after using a fully preloaded acrylic, hydrophobic, monofocal "premium" IOL in pseudoexfoliation syndrome. Materials and Methods: 42 eyes of twenty-eight patients with progressed cataract formation and pseudoexfoliation syndrome (PXF) or pseudoexfoliation glaucoma and best corrected distance visual acuity (BCDVA) between 0.30-1.00 logMAR were enrolled...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29887991/modern-corneal-eye-banking-using-a-software-based-it-management-solution
#7
C Kern, K Kortuem, C Wertheimer, O Nilmayer, M Dirisamer, S Priglinger, W J Mayer
Background: Increasing government legislation and regulations in manufacturing have led to additional documentation regarding the pharmaceutical product requirements of corneal grafts in the European Union. The aim of this project was to develop a software within a hospital information system (HIS) to support the documentation process, to improve the management of the patient waiting list and to increase informational flow between the clinic and eye bank. Materials and Methods: After an analysis of the current documentation process, a new workflow and software were implemented in our electronic health record (EHR) system...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29887990/bandage-lenses-in-the-postoperative-care-for-cataract-surgery-patients-a-substitute-for-eye-patch
#8
Hang Song, Yingyu Li, Yan Zhang, Danna Shi, Xuemin Li
Purpose: To explore whether bandage lenses could be a safe and effective substitute for eye patch in the postoperative care for cataract surgery patients in terms of infection prevention, ocular impacts, and patient satisfaction. Methods: Patients who underwent cataract surgery were randomly divided into the eye patch group (Group A) and the bandage lens group (Group B). Bacterial culture samples were collected perioperatively from different sites. Evaluations of anterior segment condition and patient satisfaction were conducted on the first day of postoperative follow-up...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29862068/ahmed-glaucoma-valve-implantation-in-vitrectomized-eyes
#9
Nimet Yeşim Erçalık, Serhat İmamoğlu
Purpose: To evaluate the outcomes of Ahmed glaucoma valve (AGV) implantation in vitrectomized eyes. Materials and Methods: The medical records of 13 eyes that developed glaucoma due to emulsified silicon oil or neovascularization following pars plana vitrectomy and underwent AGV implantation were retrospectively reviewed. The main outcome measures were intraocular pressure (IOP), best-corrected visual acuity (BCVA), number of antiglaucoma medications, and postoperative complications...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29862067/comparison-of-snp-genotypes-related-to-proliferative-vitreoretinopathy-pvr-across-slovenian-and-european-subpopulations
#10
Xhevat Lumi, Mateja M Jelen, Daša Jevšinek Skok, Emanuela Boštjančič, Metka Ravnik-Glavač, Marko Hawlina, Damjan Glavač
The present study investigated the distribution of genotypes within single nucleotide polymorphisms (SNPs) in genes, related to PVR pathogenesis across European subpopulations. Genotype distributions of 42 SNPs among 96 Slovenian healthy controls were investigated and compared to genotype frequencies in 503 European individuals (Ensembl database) and their subpopulations. Furthermore, a case-control status was simulated to evaluate effects of allele frequency changes on statistically significant results in gene-association studies investigating functional polymorphisms...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29862066/continuation-of-aspirin-therapy-before-cataract-surgery-with-different-incisions-safe-or-not
#11
Qingjian Li, Yiwen Qian, Yu Zhang, Gaoyuan Sun, Xian Zhou, Zhiliang Wang
Purpose: To assess whether to continue aspirin therapy while having uncomplicated phacoemulsification cataract surgery with different incisions. Methods: Consecutive patients having cataract surgery under topical anesthesia with different incisions between May 2016 and August 2017 were followed. 236 eyes of 166 patients on routine aspirin therapy were randomized into 2 groups: continuation group, 112 eyes; discontinuation group, 124 eyes. 121 eyes of 94 patients on no routine anticoagulant therapy were used as the control group...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29862065/effects-of-ageing-on-the-anterior-segment-of-the-eye-structure-and-function
#12
EDITORIAL
Alejandro Cerviño, Hema Radhakrishnan, José F Alfonso, Rune Brautaset, José M González-Meijome
No abstract text is available yet for this article.
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29862064/characterization-of-soft-contact-lens-edge-fitting-during-daily-wear-using-ultrahigh-resolution-optical-coherence-tomography
#13
Lele Cui, Sisi Chen, Weihe Zhou, Kaixuan Sheng, Lei Zhang, Meixiao Shen, Ming Li
Purpose: To determine conjunctival overlap over the edge of soft contact lens and to visualize the peripheral postlens tear film (PoLTF) underneath soft contact lenses using ultrahigh-resolution optical coherence tomography (UHR-OCT). Methods: Twenty participants (4 males and 16 females, 23.0 ± 3.7 years) were fitted with two different types of soft contact lenses randomly. The limbus with lens was imaged with the UHR-OCT at the horizontal meridian every two hours up to 6 hours during lens wear...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29862063/nanophthalmos-a-review-of-the-clinical-spectrum-and-genetics
#14
REVIEW
Pedro C Carricondo, Thais Andrade, Lev Prasov, Bernadete M Ayres, Sayoko E Moroi
Nanophthalmos is a clinical spectrum of disorders with a phenotypically small but structurally normal eye. These disorders present significant clinical challenges to ophthalmologists due to a high rate of secondary angle-closure glaucoma, spontaneous choroidal effusions, and perioperative complications with cataract and retinal surgeries. Nanophthalmos may present as a sporadic or familial disorder, with autosomal-dominant or recessive inheritance. To date, five genes (i.e., MFRP , TMEM98 , PRSS56 , BEST1 , and CRB1 ) and two loci have been implicated in familial forms of nanophthalmos...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29854430/vision-threatening-behcet-s-disease-severity-of-ocular-involvement-predictors
#15
Mohammed A Hussein, Iman M Eissa, Ahmed A Dahab
Purpose: To examine and spot systemic findings commonly associated with a serious form of ocular Behcet's disease. This could potentially help ophthalmologists categorize their patients based on future risk and plan treatment accordingly. Subjects and Methods: The data of 249 patients with Behcet's disease were examined thoroughly. Correlations between systemic and ocular findings were recorded. Patients were further subgrouped by the authors as having a vision-threatening form of the disease or not...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29854429/evaluation-of-vitrectomy-with-planned-foveal-detachment-as-surgical-treatment-for-refractory-diabetic-macular-edema-with-or-without-vitreomacular-interface-abnormality
#16
Ahmed M Abdel Hadi
Purpose: To evaluate the therapeutic efficacy of subretinal BSS injections done during vitrectomy for refractory diabetic macular edema (DME) resistant to other modes of treatment including previous vitrectomy. Materials and Methods: A prospective, interventional noncomparative case series in which cases had refractory DME with a central macular thickness (CMT) ≥ 300  μ m, despite previous anti-VEGF therapy (ranibizumab or bevacizumab with shifting to aflibercept)...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29854428/mutation-spectrum-of-the-abca4-gene-in-a-greek-cohort-with-stargardt-disease-identification-of-novel-mutations-and-evidence-of-three-prevalent-mutated-alleles
#17
Kamakari Smaragda, Kokkinou Vassiliki, Koutsodontis George, Stamatiou Polixeni, Giatzakis Christoforos, Anastasakis Anastasios, Aslanides Ioannis Minas, Koukoula Stavrenia, Panagiotoglou Theoni, Datseris Ioannis, Tsilimbaris K Miltiadis
Aim: To evaluate the frequency and pattern of disease-associated mutations of ABCA4 gene among Greek patients with presumed Stargardt disease (STGD1). Materials and Methods: A total of 59 patients were analyzed for ABCA4 mutations using the ABCR400 microarray and PCR-based sequencing of all coding exons and flanking intronic regions. MLPA analysis as well as sequencing of two regions in introns 30 and 36 reported earlier to harbor deep intronic disease-associated variants was used in 4 selected cases...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29854427/role-of-the-epipapillary-membrane-in-maculopathy-associated-with-cavitary-optic-disc-anomalies-morphology-surgical-outcomes-and-histopathology
#18
Atsushi Tanaka, Wataru Saito, Satoru Kase, Kan Ishijima, Kousuke Noda, Susumu Ishida
Purpose: To evaluate the surgical outcomes of pars plana vitrectomy (PPV) with epipapillary membrane removal in patients with maculopathy associated with cavitary optic disc anomalies. Methods: Eight patients (8 eyes) with cavitary optic disc anomaly-associated maculopathy who underwent PPV with epipapillary membrane removal were retrospectively reviewed. The best-corrected visual acuity (BCVA) and macular and papillary morphologies using enhanced depth imaging optical coherence tomography (EDI-OCT) were evaluated before and after treatment...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29854426/evaluation-of-navigated-laser-photocoagulation-navilas-577-for-the-treatment-of-refractory-diabetic-macular-edema
#19
Fusae Kato, Miho Nozaki, Aki Kato, Norio Hasegawa, Hiroshi Morita, Munenori Yoshida, Yuichiro Ogura
Purpose: To evaluate navigated laser photocoagulation for the treatment of refractory diabetic macular edema (DME). Methods: Retrospective study of 25 eyes (21 patients) treated with Navilas 577+ focal laser system. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (OCT) parameters were measured at baseline, 1, 3, and 6 months, and final visit. Results: The mean follow-up period was 12.8 ± 2.4 (7-16 months)...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29854425/flt3-regulation-in-the-mononuclear-phagocyte-system-promotes-ocular-neovascularization
#20
Yushuo Gao, Yisheng Zhong, Yanji Zhu, Anna M Demetriades, Yujuan Cai, Jikui Shen, Qing Lu, Xi Shen, Bing Xie
Fms-like tyrosine kinase 3 (Flt3), a tyrosine kinase receptor expressed in CD34+ hematopoietic stem/progenitor cells, is important for both normal myeloid and lymphoid differentiation. It has been implicated in mice and humans for potential multilineage differentiation. We found that mice deficient in Flt3 or mice that received an Flt3 inhibitor (AC220) showed significantly reduced areas of ischemia-induced retinal neovascularization (RNV) and laser-induced choroidal NV (CNV) ( P < 0.05). Increased Flt3 expression at the protein level was detected in retinas of oxygen-induced retinopathy (OIR) mice at P15 and P18 during retinal NV (RNV) progression...
2018: Journal of Ophthalmology
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