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Cell Death & Disease

Suhaib K Abdeen, Uri Ben-David, Aya Shweiki, Bella Maly, Rami I Aqeilan
Inactivation of WW domain-containing oxidoreductase (WWOX), the gene product of the common fragile site FRA16D, is a common event in breast cancer and is associated with worse prognosis of triple-negative breast cancer (TNBC) and basal-like breast cancer (BLBC). Despite recent progress, the role of WWOX in driving breast carcinogenesis remains unknown. Here we report that ablation of Wwox in mammary tumor-susceptible mice results in increased tumorigenesis, and that the resultant tumors resemble human BLBC...
August 6, 2018: Cell Death & Disease
Rui-Chao Li, Shun Ke, Fan-Kai Meng, Jun Lu, Xiao-Jing Zou, Zhi-Gang He, Weng-Feng Wang, Ming-Hao Fang
The circular RNA ciRS-7 has been reported to be involved in the pathogenesis of various tumors, including gastric and colorectal cancer. However, the role of ciRS-7 in esophageal squamous cell carcinoma (ESCC) remains unsolved. In this study, we found that the ciRS-7 expression was significantly upregulated in ESCC cancer tissues compared with matched normal tissues and associated with poor patient survival. Overexpression of ciRS-7 abrogated the tumor-suppressive roles of miR-7 including cell proliferation, migration and invasion in vitro as well as tumor growth and lung metastasis in vivo...
August 6, 2018: Cell Death & Disease
Tej Pratap Singh, Pablo A Vieyra-Garcia, Karin Wagner, Josef Penninger, Peter Wolf
Exposure of skin to ultraviolet (UV) radiation induces DNA damage, inflammation, and immune suppression that ultimately lead to skin cancer. However, some of the pathways that regulate these events are poorly understood. We exposed mice to UVB to study its early effects in the absence of Cbl-b, a known suppressor of antitumor immune response in the skin. Cbl-b-/- mice were protected from UV-induced cell damage as shown by the lower number of cyclobutane pyrimidine dimers and sunburn cells in exposed skin compared to wild-type mice...
August 6, 2018: Cell Death & Disease
Wuzheng Zhu, Yujia Yuan, Guangneng Liao, Lan Li, Jingping Liu, Younan Chen, Jie Zhang, Jingqiu Cheng, Yanrong Lu
Mitochondrial dysfunction and excessive mitochondrial reactive oxygen species (ROS) are fundamental contributors to endothelial injury in diabetic states. Mesenchymal stem cells (MSCs) have exhibited an extraordinary cytoprotective effect that extends to the modulation of mitochondrial homeostasis. However, the underlying mechanisms have not been clearly defined. Emerging evidence has suggested that mitophagy could counteract mitochondrial-derived oxidative stress through the selective elimination of impaired or dysfunctional mitochondria...
August 6, 2018: Cell Death & Disease
Dhia Azzouz, Nades Palaniyar
No abstract text is available yet for this article.
August 6, 2018: Cell Death & Disease
Cristiana Mollinari, Jian Zhao, Leonardo Lupacchini, Enrico Garaci, Daniela Merlo, Gang Pei
Neurodegenerative diseases are characterized by a gradual loss of cognitive and physical functions. Medications for these disorders are limited and treat the symptoms only. There are no disease-modifying therapies available, which have been shown to slow or stop the continuing loss of neurons. Transdifferentiation, whereby somatic cells are reprogrammed into another lineage without going through an intermediate proliferative pluripotent stem cell stage, provides an alternative strategy for regenerative medicine and disease modeling...
August 6, 2018: Cell Death & Disease
Maria P Ikonomopoulou, Manuel A Fernandez-Rojo
No abstract text is available yet for this article.
August 6, 2018: Cell Death & Disease
De Li, Chenglong Wang, Zhuokai Li, Hui Wang, Jiye He, Junfeng Zhu, Yuehui Zhang, Chao Shen, Fei Xiao, Yuan Gao, Xiang Zhang, Yang Li, Peng Wang, Jianping Peng, Guiquan Cai, Bin Zuo, Yuehua Yang, Yun Shen, Weidong Song, Xiaoling Zhang, Lei Shen, Xiaodong Chen
Aseptic loosening is mainly caused by wear debris generated by friction that can increase the expression of receptor activation of nuclear factor (NF)-κB (RANKL). RANKL has been shown to support the differentiation and maturation of osteoclasts. Although autophagy is a key metabolic pathway for maintaining the metabolic homeostasis of cells, no study has determined whether autophagy induced by Al2 O3 particles is involved in the pathogenesis of aseptic loosening. The aim of this study was to evaluate RANKL levels in patients experiencing aseptic loosening after total hip arthroplasty (THA) and hip osteoarthritis (hOA) and to consequently clarify the relationship between RANKL and LC3II expression...
August 6, 2018: Cell Death & Disease
Hwa Jin Kim, Sue Jin Moon, Seok-Hyung Kim, Kyu Heo, Jeong Hoon Kim
Metastasis-associated in colon cancer 1 (MACC1) has been reported to be overexpressed in multiple cancers and promote proliferation, metastasis, cancer stem cell-like properties, and drug resistance of cancer cells. Despite its significance and the considerable knowledge accumulated on the function of MACC1 in various types of human malignancies, regulatory mechanisms underlying MACC1 expression remain unclear. Here we report that MACC1 is a direct target of Wnt/β-catenin signaling pathway in colon cancer cells and that DBC1 functions as a coactivator for Wnt-mediated MACC1 expression by promoting the activity of a LEF1/β-catenin-dependent enhancer located in intron 1 of MACC1 gene...
August 6, 2018: Cell Death & Disease
Chenyi Ye, Mo Chen, Erman Chen, Weixu Li, Shengdong Wang, Qianhai Ding, Cong Wang, Chenhe Zhou, Lan Tang, Weiduo Hou, Kai Hang, Rongxin He, Zhijun Pan, Wei Zhang
Forkhead box protein A2 (FOXA2) is a core transcription factor that controls cell differentiation and may have an important role in bone metabolism. However, the role of FOXA2 during osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) remains largely unknown. In this study, decreased expression of FOXA2 was observed during osteogenic differentiation of rat BMSCs (rBMSCs). FOXA2 knockdown significantly increased osteoblast-specific gene expression, the number of mineral deposits and alkaline phosphatase activity, whereas FOXA2 overexpression inhibited osteogenesis-specific activities...
August 6, 2018: Cell Death & Disease
Shuang Wei, Zun-Yi Zhang, Sheng-Ling Fu, Jun-Gang Xie, Xian-Sheng Liu, Yong-Jian Xu, Jian-Ping Zhao, Wei-Ning Xiong
Following publication of their article, the authors noticed that there were minor errors in Figs. 3, 7 and S5. The errors had no effect on the scientific content or conclusions. The rectified figures are given below.
August 6, 2018: Cell Death & Disease
Jieying Peng, Yuhao Zhou, Zhiyu Zhang, Zhiming Wang, Lingtong Gao, Xiao Zhang, Zhou Fang, Guangyao Li, Huaiyan Chen, Hongxing Yang, Lu Gao
The intra-uterine and external environmental factors not only affect the early development of fetuses, their interaction with genesis will also substantially program the physiological functions of offspring throughout life. Synthetic glucocorticoid (GC) is widely used for the management of women at risk of preterm birth or undergone autoimmune diseases. However, excess GC might cause a number of chronic diseases in later life. In the present study, we set up a programming rat model by daily injection of dexamethasone (DEX) since 14...
August 6, 2018: Cell Death & Disease
Mariachiara Buccarelli, Matteo Marconi, Simone Pacioni, Ivana De Pasqualis, Quintino Giorgio D'Alessandris, Maurizio Martini, Barbara Ascione, Walter Malorni, Luigi Maria Larocca, Roberto Pallini, Lucia Ricci-Vitiani, Paola Matarrese
The role of autophagy in cancer onset and progression appears still controversial. On one hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on the other hand, once internal energy resources are exhausted, it leads to cell death. In addition, autophagy interpheres with cell cycle progression, de facto exerting a cytostatic activity. Hence, it represents an important target for anticancer therapy. For example, temozolomide (TMZ), of use for glioblastoma (GBM) treatment, appears as capable of inducing autophagy partially inhibiting cancer cell proliferation...
August 6, 2018: Cell Death & Disease
Micol Silic-Benussi, Gloria Scattolin, Ilaria Cavallari, Sonia Minuzzo, Paola Del Bianco, Samuela Francescato, Giuseppe Basso, Stefano Indraccolo, Donna M D'Agostino, Vincenzo Ciminale
Approximately 20% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients are currently incurable due to primary or secondary resistance to glucocorticoid-based therapies. Here we employed an integrated approach to selectively kill T-ALL cells by increasing mitochondrial reactive oxygen species (ROS) using NS1619, a benzimidazolone that activates the K+ (BK) channel, and dehydroepiandrosterone (DHEA), which blunts ROS scavenging through inhibition of the pentose phosphate pathway. These compounds selectively killed T-ALL cell lines, patient-derived xenografts and primary cells from patients with refractory T-ALL, but did not kill normal human thymocytes...
August 1, 2018: Cell Death & Disease
Koyo Nishiyama, Reo Maruyama, Takeshi Niinuma, Masahiro Kai, Hiroshi Kitajima, Mutsumi Toyota, Yui Hatanaka, Tomohiro Igarashi, Jun-Ichi Kobayashi, Kazuhiro Ogi, Hironari Dehari, Akihiro Miyazaki, Akira Yorozu, Eiichiro Yamamoto, Masashi Idogawa, Yasushi Sasaki, Tamotsu Sugai, Takashi Tokino, Hiroyoshi Hiratsuka, Hiromu Suzuki
Recent studies have shown that long noncoding RNAs (lncRNAs) have pivotal roles in human malignancies, although their significance in oral squamous cell carcinoma (OSCC) is not fully understood. In the present study, we identified lncRNAs functionally associated with OSCC. By analyzing RNA-seq datasets obtained from primary head and neck squamous cell carcinoma (HNSCC), we identified 15 lncRNAs aberrantly expressed in cancer tissues. We then validated their expression in 18 OSCC cell lines using qRT-PCR and identified 6 lncRNAs frequently overexpressed in OSCC...
August 1, 2018: Cell Death & Disease
Se-Ra Park, Ara Cho, Sung Taek Park, Chan Hum Park, Soyi Lim, Mirim Jin, Hwa-Yong Lee, In-Sun Hong
Gonadotropin-releasing hormone (GnRH) stimulates the synthesis and release of gonadotropins, which induce estrogen production and subsequent ovulation. Therefore, long-term GnRH exposure to regulate ovarian hyperstimulation is recognized as the gold standard for most in vitro fertilization (IVF) strategies. However, one of the most disappointing aspects of current IVF technology is relatively low rate (between 35 and 50%) of positive pregnancy outcomes, and the major reason for this high cancellation rate has not yet been revealed...
August 1, 2018: Cell Death & Disease
Ji-Su Jang, Jun-Ho Lee, Nam-Chul Jung, So-Yeon Choi, Soo-Yeoun Park, Ji-Young Yoo, Jie-Young Song, Han Geuk Seo, Hyun Soo Lee, Dae-Seog Lim
Dendritic cells (DCs) are the most potent professional antigen presenting cells and inducers of T cell-mediated immunity. However, few specific markers of mature DCs (mDC) have been reported. A previous microarray analysis revealed expression of mDC-specific genes and identified Rsad2 (radical S-adenosyl methionine domain containing 2) as a candidate specific marker for DC maturation. Mouse bone marrow-derived DCs were transfected with Rsad2 siRNA and examined by flow cytometry, ELISA, western, and confocal microscopy...
August 1, 2018: Cell Death & Disease
Amit Gupta, Athira Ajith, Smriti Singh, Rajendra Kumar Panday, Atul Samaiya, Sanjeev Shukla
The histone modifiers (HMs) are crucial for chromatin dynamics and gene expression; however, their dysregulated expression has been observed in various abnormalities including cancer. In this study, we have analyzed the expression of HMs in microarray profiles of head and neck cancer (HNC), wherein a highly significant overexpression of p21-activated kinase 2 (PAK2) was identified which was further validated in HNC patients. The elevated expression of PAK2 positively correlated with enhanced cell proliferation, aerobic glycolysis and chemoresistance and was associated with the poor clinical outcome of HNC patients...
August 1, 2018: Cell Death & Disease
Kyung-Hee Kim, Byeonghyeon Lee, Ye-Ri Kim, Min-A Kim, Nari Ryu, Da Jung Jung, Un-Kyung Kim, Jeong-In Baek, Kyu-Yup Lee
Cisplatin, a small platinum-containing molecule, is a widely used, highly effective anticancer drug. However, severe side effects have been found in cancer patients treated with cisplatin, including nephrotoxicity, neurotoxicity, and ototoxicity. These cisplatin-induced side effects can have a major impact on patient quality of life, including social development problems in pediatric patients that develop hearing loss. Previous studies have suggested that the major cause of cisplatin-induced ototoxicity is abnormal accumulation of reactive oxygen species (ROS) and oxidative stress...
August 1, 2018: Cell Death & Disease
Haidong Sun, Qian Liu, Hai Hu, Yisheng Jiang, Wentao Shao, Qihan Wang, Zhaoyan Jiang, Aihua Gu
Excessive cholesterol contributes to the development of cardiovascular diseases. Berberine (BBR) has been reported to regulate cholesterol homeostasis. Here, we found that BBR could ameliorate the hepatic autophagic flux blockade caused by cholesterol overloading. The underlying mechanism included lowering hepatic cholesterol level, modulating the cholesterol distribution targeting the plasma membrane by decreasing sterol carrier protein 2 expression and inhibiting cyclooxygenase 2-mediated production of prostaglandin metabolites, which decreased the phosphorylation of Akt/mTOR...
August 1, 2018: Cell Death & Disease
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