Jie Wu, Ting Wen, Antonio Marzio, Dingli Song, Sisi Chen, Chengcheng Yang, Fengyu Zhao, Boxiang Zhang, Guang Zhao, Alessandra Ferri, Hao Cheng, Jiao Ma, Hong Ren, Qiao Yi Chen, Yiping Yang, Sida Qin
FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, the functions and the molecular mechanisms regulated by FBXO32 in lung adenocarcinoma (LUAD) remain unclear. Here, we report that FBXO32 is overexpressed in LUAD compared with normal lung tissues, and high expression of FBXO32 correlates with poor prognosis in LUAD patients. Firstly, we observed with a series of functional experiments that FBXO32 alters the cell cycle and promotes the invasion and metastasis of LUAD cells...
April 20, 2024: Cell Death & Disease