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Cell Death & Disease

Sanjeev Kumar Sagwal, Gabriella Pasqual-Melo, Yana Bodnar, Rajesh Kumar Gandhirajan, Sander Bekeschus
Malignant melanoma is an aggressive cancer that develops drug resistance leading to poor prognosis. Efficient delivery of chemotherapeutic drugs to the tumor tissue remains a major challenge in treatment regimens. Using murine (B16) and human (SK-MEL-28) melanoma cells, we investigated traditional cytotoxic agents in combination with cold physical plasma-derived oxidants. We report synergistic cytotoxicity of doxorubicin and epirubicin, and additive toxicity of oxaliplatin with plasma exposure in coefficient of drug interaction analysis...
December 5, 2018: Cell Death & Disease
Jianming Tang, Guangsheng Zhong, Haibo Zhang, Bo Yu, Fangqiang Wei, Liming Luo, Yao Kang, Jianhui Wu, Jiaxiang Jiang, Yucheng Li, Shuqiang Wu, Yongshi Jia, Xiaodong Liang, Aihong Bi
Conventional therapies and novel molecular targeted therapies against breast cancer have gained great advances over the past two decades. However, poor prognosis and low survival rate are far from expectation for improvement, particularly in patients with triple negative breast cancer (TNBC). Here, we found that lncRNA DANCR was significantly overregulated in TNBC tissues and cell lines compared with normal breast tissues or other type of breast cancer. Knockdown of DANCR suppressed TNBC proliferation both in vitro and in vivo...
December 5, 2018: Cell Death & Disease
Flavia Biamonte, Anna Martina Battaglia, Fabiana Zolea, Duarte Mendes Oliveira, Ilenia Aversa, Gianluca Santamaria, Emilia Dora Giovannone, Gaetano Rocco, Giuseppe Viglietto, Francesco Costanzo
Ferritin is a nanocage protein composed by the variable assembly of 24 heavy and light subunits. As major intracellular iron storage protein, ferritin has been studied for many years in the context of iron metabolism. However, recent evidences have highlighted its role, in particular that of the heavy subunit (FHC), in pathways related to cancer development and progression, such as cell proliferation, growth suppressor evasion, cell death inhibition, and angiogenesis. At least partly, the involvement in these pathways is due to the ability of FHC to control the expression of a repertoire of oncogenes and oncomiRNAs...
December 5, 2018: Cell Death & Disease
Marta Varela-Eirín, Adrián Varela-Vázquez, Amanda Guitián-Caamaño, Carlos Luis Paíno, Virginia Mato, Raquel Largo, Trond Aasen, Arantxa Tabernero, Eduardo Fonseca, Mustapha Kandouz, José Ramón Caeiro, Alfonso Blanco, María D Mayán
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and senescence, restricting cartilage regeneration and favouring disease progression. Similar to other wound-healing disorders, chondrocytes from OA patients show a chronic increase in the gap junction channel protein connexin43 (Cx43), which regulates signal transduction through the exchange of elements or recruitment/release of signalling factors...
December 5, 2018: Cell Death & Disease
Rong-Hui Li, Min Chen, Jing Liu, Chang-Chun Shao, Cui-Ping Guo, Xiao-Long Wei, Yao-Chen Li, Wen-He Huang, Guo-Jun Zhang
Recent studies indicate that the long noncoding RNA ATB (lncATB) can induce the epithelial-mesenchymal transition (EMT) in cancer cells, but the specific cellular targets of lncATB require further investigation. In the present study, the upregulation of lncATB in breast cancer cells was validated in a TGF-β-induced EMT model. Gain- and loss-of-function studies demonstrated that lncATB enhanced cell migration, invasion and clonogenicity in vitro and in vivo. LncATB promoted the EMT by acting as a sponge for the miR-200 family and restoring Twist1 expression...
December 5, 2018: Cell Death & Disease
Zhigang He, Jian Song, Jie Hua, Muqing Yang, Yuanyuan Ma, Tianyu Yu, Junlan Feng, Bin Liu, Xiaodong Wang, Yue Li, Jiyu Li
Mast cells (MCs) are potent tissue-resident immune cells that are distributed in the intraepithelial space of the intestine and have been implicated in regulating immune homeostasis and coordinating epithelial responses in inflamed mucosa of inflammatory bowel disease (IBD). IL-33 functions as an endogenous danger signal or alarmin in inflamed intestine segments. MCs highly express the IL-33 receptor ST2. However, the mechanisms underlying the immune regulation of MC-dependent IL-33/ST2 signaling at the barrier surface of the intestine remain largely unknown...
December 5, 2018: Cell Death & Disease
Yoshiyuki Nakamura, Takashi Matsuzaka, Satoko Tahara-Hanaoka, Kazuko Shibuya, Hitoshi Shimano, Chigusa Nakahashi-Oda, Akira Shibuya
Mechanical damage on the skin not only affects barrier function but also induces various immune responses, which trigger or exacerbate skin inflammation. However, how mechanical damage-induced skin inflammation is regulated remains incompletely understood. Here, we show that keratinocytes express the long-chain fatty-acid elongase Elovl6. Mice deficient in Elovl6 showed higher levels of cis-vaccenic acid (CVA) in the epidermis and severe skin inflammation induced by mechanical damage due to tape stripping than did wild-type mice...
December 5, 2018: Cell Death & Disease
Zhiliang Xu, Fengsen Duan, Huiai Lu, Maytham Abdulkadhim Dragh, Yanzhi Xia, Huageng Liang, Ling Hong
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) plays a key role in biosynthesis of vitamin K2 and coenzyme Q10 using geranylgeranyl diphosphate (GGPP). However, the mechanism by which UBIAD1 participates in tumorigenesis remains unknown. This study show that UBIAD1 interacts with H-Ras, retains H-Ras in the Golgi apparatus, prevents H-Ras trafficking from the Golgi apparatus to the plasma membrane, blocks the aberrant activation of Ras/MAPK signaling, and inhibits the proliferation of bladder cancer cells...
December 5, 2018: Cell Death & Disease
Feifei Chen, Lei Zhang, Jianqiang Wu, Fuchun Huo, Xin Ren, Junnian Zheng, Dongsheng Pei
Hepatocellular carcinoma-related protein-1 (HCRP-1), a subunit of mammalian endosomal sorting complex required for transport-I (ESCRT-I), is frequently downregulated in various kinds of malignant tumors. The role of HCRP-1 in colorectal cancer (CRC) remains unknown. We investigate the clinical value of HCRP-1 and its impact on anoikis in CRC. The negative expression of HCRP-1 was significantly correlated with tumor size (P = 0.033), PT status (P = 0.001), TNM stage (P = 0.039), and histological grade (P = 0...
December 5, 2018: Cell Death & Disease
Panpan Zhang, Qiuping He, Yuan Lei, Yingqin Li, Xin Wen, Mengzhi Hong, Jian Zhang, Xianyue Ren, Yaqin Wang, Xiaojing Yang, Qingmei He, Jun Ma, Na Liu
Nasopharyngeal carcinoma (NPC) progression is regulated by genetic, epigenetic, and epitranscript modulation. As one of the epitranscript modifications, the role of N6-Methyladenosine (m6 A) has not been elucidated in NPC. In the present study, we found that the poorly methylated gene ZNF750 (encoding zinc finger protein 750) was downregulated in NPC tumor tissues and cell lines. Ectopic expression of ZNF750 blocked NPC growth in vitro and in vivo. Further studies revealed that m6 A modifications maintained the low expression level of ZNF750 in NPC...
December 5, 2018: Cell Death & Disease
Ana Campos Codo, Amanda Correia Saraiva, Leonardo Lima Dos Santos, Marina Francisco Visconde, Ana Cristina Gales, Dario Simões Zamboni, Alexandra Ivo Medeiros
Klebsiella pneumoniae is a Gram-negative bacterium responsible for severe cases of nosocomial pneumonia. During the infectious process, both neutrophils and monocytes migrate to the site of infection, where they carry out their effector functions and can be affected by different patterns of cell death. Our data show that clinical strains of K. pneumoniae have dissimilar mechanisms for surviving within macrophages; these mechanisms include modulation of microbicidal mediators and cell death. The A28006 strain induced high IL-1β production and pyroptotic cell death in macrophages; by contrast, the A54970 strain induced high IL-10 production and low IL-1β production by macrophages...
December 5, 2018: Cell Death & Disease
Lidan Ding, Liu Yang, Yuqi He, Bingtao Zhu, Fangli Ren, Xuanzi Fan, Yinyin Wang, Mengdi Li, Jun Li, Yanshen Kuang, Sihan Liu, Wanli Zhai, Danhui Ma, Yanfang Ju, Quentin Liu, Baoqing Jia, Jianqiu Sheng, Zhijie Chang
Gastric cancer, like most of other cancers, has an uncontrolled cell cycle regulated by cyclins and cyclin-dependent kinases (CDKs). In this study, we reported that gastric cancer cells showed an accelerated G2/M transition promoted by CREPT/RPRD1B and Aurora kinase B (Aurora B). We found that CREPT/RPRD1B and Aurora B were coordinately expressed during the cell cycle in gastric cancer cells. Deletion of CREPT/RPRD1B disturbed the cell progression and extended the length of cell cycle, leading to a significant accumulation of mitotic cells...
December 5, 2018: Cell Death & Disease
Sandra Fuertes-Alvarez, Laura Maeso-Alonso, Javier Villoch-Fernandez, Merit Wildung, Marta Martin-Lopez, Clayton Marshall, Alberto J Villena-Cortes, Inmaculada Diez-Prieto, Jennifer A Pietenpol, Fadel Tissir, Muriel Lizé, Margarita M Marques, Maria C Marin
Planar cell polarity (PCP) and intercellular junctional complexes establish tissue structure and coordinated behaviors across epithelial sheets. In multiciliated ependymal cells, rotational and translational PCP coordinate cilia beating and direct cerebrospinal fluid circulation. Thus, PCP disruption results in ciliopathies and hydrocephalus. PCP establishment depends on the polarization of cytoskeleton and requires the asymmetric localization of core and global regulatory modules, including membrane proteins like Vangl1/2 or Frizzled...
December 5, 2018: Cell Death & Disease
Xiaohui Rui, Yun Xu, Xiping Jiang, Wenfeng Ye, Yaqing Huang, Jingting Jiang
Long non-coding RNA (lncRNA) plays an important role in the development of human malignant tumours. Recently, an increasing number of lncRNAs have been identified and investigated in a variety of tumours. However, the expression pattern and biological function of lncRNAs in cervical cancer still remain largely unexplored. Differentially expressed lncRNAs in cervical cancer and para-carcinoma tissues were identified by screening using The Cancer Genome Atlas (TCGA), and candidate lncRNAs were verified by quantitative real-time PCR...
December 5, 2018: Cell Death & Disease
Chaoqin Shen, Tingting Yan, Zhenhua Wang, Heng-Chuan Su, Xiaoqiang Zhu, Xianglong Tian, Jing-Yuan Fang, Haoyan Chen, Jie Hong
Genome-wide association studies (GWAS) have identified several loci harboring variants that affected the risk of colorectal cancer; however, the specific mechanisms by which germline variation influenced the tumorigenesis of colorectal cancer (CRC) remains unrevealed. We found the T>C variant of rs1317082, locating at the exon 1 of lncRNA RP11-362K14.5 (CCSlnc362), was predicted to be a protective locus for cancer. However, the specific role of CCSlnc362 and the interaction between CCSlnc362 and rs1317082 variation in colorectal cancer and its mechanisms remain unclear...
December 5, 2018: Cell Death & Disease
Zirong Fan, Jian Zheng, Yixue Xue, Xiaobai Liu, Di Wang, Chunqing Yang, Jun Ma, Libo Liu, Xuelei Ruan, Zhenhua Wang, Yunhui Liu
Accumulating evidence has highlighted the potential role of non-coding RNAs (ncRNAs) and upstream open-reading frames (uORFs) in the biological behaviors of glioblastoma. Here, we elucidated the function and possible molecular mechanisms of the effect of some ncRNAs and NR2C2-uORF on the biological behaviors of gliomas. Quantitative real-time PCR was conducted to profile the cell expression of lnc-UCA1 and microRNA-627-5p (miR-627-5p) in glioma tissues and cells. Western blot assay was used to determine the expression levels of NR2C2, SPOCK1, and NR2C2-uORF in glioma tissues and cells...
December 5, 2018: Cell Death & Disease
Elisabetta Caprini, Antonella Bresin, Cristina Cristofoletti, Mauro Helmer Citterich, Valeria Tocco, Enrico Scala, Alessandro Monopoli, Roberto Benucci, Maria Grazia Narducci, Giandomenico Russo
Cutaneous T-cell lymphoma is a group of incurable extranodal non-Hodgkin lymphomas that develop from the skin-homing CD4+ T cell. Mycosis fungoides and Sézary syndrome are the most common histological subtypes. Although next-generation sequencing data provided significant advances in the comprehension of the genetic basis of this lymphoma, there is not uniform consensus on the identity and prevalence of putative driver genes for this heterogeneous group of tumors. Additional studies may increase the knowledge about the complex genetic etiology characterizing this lymphoma...
December 5, 2018: Cell Death & Disease
Songman Yu, Ning Li, Zebing Huang, Ruochan Chen, Panpan Yi, Rui Kang, Daolin Tang, Xingwang Hu, Xuegong Fan
Hepatocellular carcinoma (HCC) is one of the most common malignancies and has an unfavorable prognosis. The hepatitis B virus X (HBx) protein has been reported to be closely associated with hepatocarcinogenesis. Meanwhile, emerging evidence has indicated that long noncoding RNAs (lncRNAs) are involved in the pathogenesis and progression of cancers. Our previous investigation has demonstrated that HBx could promote HCC by regulating the expression levels of various lncRNAs. In this study, we identified an lncRNA, lncRNA-TCONS_00006195 (termed lncRNA-6195), which was downregulated in HBV-related HCC tissues compared with its expression in adjacent noncancerous hepatic tissues...
December 5, 2018: Cell Death & Disease
Gautam Pareek, Leo J Pallanck
The mitochondrial Unfolded Protein Response (UPRmt ) pathway confers protection from misfolded and aggregated proteins by activating factors that promote protein folding and degradation. Our recent work on Lon protease, a member of the mitochondrial ATPase Associated with diverse cellular Activities (AAA+ ) family of mitochondrial resident proteases, suggests that mitochondrial translational inhibition may also be a feature of the UPRmt pathway.
December 5, 2018: Cell Death & Disease
Sen Chen, Kai Xu, Le Xie, Hai-Yan Cao, Xia Wu, An-Na Du, Zu-Hong He, Xi Lin, Yu Sun, Wei-Jia Kong
Mutations in the GJB2 gene (which encodes Connexin26 (Cx26)) account for about a quarter of all cases of non-syndromic deafness. Previous studies have indicated that knockout (KO) of Gjb2 gene during early postnatal days can cause outer hair cell (OHC) loss in mouse models. However, the postnatal spatial distribution pattern of Cx26 in different types of supporting cells (SCs) and the role of such distributions for the survival of OHCs is still obscure. In this study, the spatial distribution patterns of Cx26 in SCs were observed, and based on these observations different spatial Cx26-null mouse models were established in order to determine the effect of changes in the spatial distribution of Cx26 in SCs on the survival of OHCs...
December 5, 2018: Cell Death & Disease
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