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Biofabrication

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https://www.readbyqxmd.com/read/27910820/4d-bioprinting-the-next-generation-technology-for-biofabrication-enabled-by-stimuli-responsive-materials
#1
Yi-Chen Li, Yu Shrike Zhang, Ali Akpek, Su Ryon Shin, Ali Khademhosseini
Four-dimensional (4D) bioprinting, encompassing a wide range of disciplines including bioengineering, materials science, chemistry, and computer sciences, is emerging as the next-generation biofabrication technology. By utilizing stimuli-responsive materials and advanced three-dimensional (3D) bioprinting strategies, 4D bioprinting aims to create dynamic 3D patterned biological structures that can transform their shapes or behavior under various stimuli. In this review, we highlight the potential use of various stimuli-responsive materials for 4D printing and their extension into biofabrication...
December 2, 2016: Biofabrication
https://www.readbyqxmd.com/read/27906688/layer-by-layer-approach-for-a-uniformed-fabrication-of-a-cell-patterned-vessel-like-construct
#2
Camila A Wilkens, Christopher J Rivet, Tamara L Akentjew, Julian Alverio, Maroun Khoury, Juan Pablo Acevedo
Successful tissue engineered small diameter blood vessels (SDBV) require manufacturing systems capable of precisely controlling different key elements, such as material composition, geometry and spatial location of specialized biomaterials and cells types. We report in this work an automated methodology that enables the manufacture of multilayer cylindrical constructs for SDBV fabrication that uses a layer-by-layer deposition approach while controlling variables such as dipping and spinning speed of a rod and biomaterial viscosity...
December 1, 2016: Biofabrication
https://www.readbyqxmd.com/read/27906687/economic-3d-printing-approach-for-transplantation-of-human-stem-cell-derived-%C3%AE-like-cells
#3
Jiwon Song, Jeffrey R Millman
Transplantation of human pluripotent stem cells (hPSC) differentiated into insulin-producing β cells is a regenerative medicine approach being investigated for diabetes cell replacement therapy. This report presents a multifaceted transplantation strategy that combines differentiation into stem cell-derived β (SC-β) cells with 3D printing. By modulating the parameters of a low-cost 3D printer, we created a macroporous device composed of polylactic acid (PLA) that houses SC-β cell clusters within a degradable fibrin gel...
December 1, 2016: Biofabrication
https://www.readbyqxmd.com/read/27845938/elastin-like-recombinamers-multilayered-nanofibrous-scaffolds-for-cardiovascular-applications
#4
M Putzu, F Causa, V Nele, I González de Torre, J C Rodriguez-Cabello, P A Netti
Coronary angioplasty is the most widely used technique for removing atherosclerotic plaques in blood vessels. The regeneration of the damaged intima layer after this treatment is still one of the major challenges in the field of cardiovascular tissue engineering. Different polymers have been used in scaffold manufacturing in order to improve tissue regeneration. Elastin-mimetic polymers are a new class of molecules that have been synthesized and used to obtain small diameter fibers with specific morphological characteristics...
November 15, 2016: Biofabrication
https://www.readbyqxmd.com/read/27788126/3d-printed-polyurethane-prosthesis-for-partial-tracheal-reconstruction-a-pilot-animal-study
#5
Soo Yeon Jung, Sang Jin Lee, Ha Yeong Kim, Hae Sang Park, Zhan Wang, Hyun Jun Kim, James J Yoo, Sung Min Chung, Han Su Kim
A ready-made, acellular patch-type prosthesis is desirable in repairing partial tracheal defects in the clinical setting. However, many of these prostheses may not show proper biological integration and biomechanical function when they are transplanted. In this study, we developed a novel 3D printed polyurethane (PU) tracheal scaffold with micro-scale architecture to allow host tissue infiltration and adequate biomechanical properties to withstand physiological tracheal condition. A half-pipe shaped PU scaffold (1...
October 27, 2016: Biofabrication
https://www.readbyqxmd.com/read/27788125/high-performance-bio-based-hyperbranched-polyurethane-carbon-dot-silver-nanocomposite-a-rapid-self-expandable-stent
#6
Rituparna Duarah, Yogendra P Singh, Prerak Gupta, Biman B Mandal, Niranjan Karak
Development of a bio-based smart implantable material with multifaceted attributes of high performance, potent biocompatibility and inherent antibacterial property, particularly against drug resistant bacteria, is a challenging task in biomedical domain. Addressing these aspects at the bio-nano interface, we report the in situ fabrication of starch modified hyperbranched polyurethane (HPU) nanocomposites by incorporating different weight percentages of carbon dot-silver nanohybrid during polymerization process...
October 27, 2016: Biofabrication
https://www.readbyqxmd.com/read/27788123/osseointegration-of-three-dimensional-designed-titanium-implants-manufactured-by-selective-laser-melting
#7
Algabri Shaoki, Jia-Yun Xu, Haipeng Sun, Xian-Shuai Chen, Jianglin Ouyang, Xiu-Mei Zhuang, Fei-Long Deng
The selective laser melting (SLM) technique is a recent additive manufacturing (AM) technique. Several studies have reported success in the SLM-based production of biocompatible orthopaedic implants and three-dimensional bone defect constructs. In this study, we evaluated the surface properties and biocompatibility of an SLM titanium implant in vitro and compared them with those of a machined (MA) titanium control surface. In addition, we evaluated the osseointegration capability of the SLM implants in vivo and compared it with those of MA and Nobel-speedy (Nobel-S) implants...
October 27, 2016: Biofabrication
https://www.readbyqxmd.com/read/27788122/incorporating-simvastatin-poloxamer-407-hydrogel-into-3d-printed-porous-ti6al4v-scaffolds-for-the-promotion-of-angiogenesis-osseointegration-and-bone-ingrowth
#8
Hao Liu, Wei Li, Can Liu, Jie Tan, Hong Wang, Bao Hai, Hong Cai, Hui-Jie Leng, Zhong-Jun Liu, Chun-Li Song
Three-dimensional porous titanium alloys printed via electron beam melting have low stiffness similar to that of cortical bone and are promising scaffolds for orthopedic applications. However, the bio-inert nature of titanium alloy is poorly compatible with bone ingrowth. We previously observed that simvastatin/poloxamer 407 thermosensitive hydrogel induces endogenous angiogenic/osteogenic growth factors and promotes angiogenesis and osteogenesis, but the mechanical properties of this hydrogel are poor. The purpose of this study was to construct 3D-printed porous titanium scaffolds (pTi scaffolds) filled with simvastatin/hydrogel and evaluate the effects of this composite on osseointegration, bone ingrowth and neovascularization using a tibial defect rabbit model...
October 27, 2016: Biofabrication
https://www.readbyqxmd.com/read/27775924/poly-l-lactic-acid-scaffold-with-oriented-micro-valley-surface-and-superior-properties-fabricated-by-solid-state-drawing-for-blood-contact-biomaterials
#9
Seung Hyuk Im, Youngmee Jung, Yangsoo Jang, Soo Hyun Kim
Most biomaterials composed of biodegradable polymers will contact either accidentally or consistently with blood and this commonly requires both good  mechanical strength and blood compatibility. Despite this demand, current processing methods still make it difficult and complex to simultaneously improve the two properties. To overcome present limitations, the aim of this work is to develop a solid-state drawing which is a novel method for blood-contact biomaterials that can simultaneously improve the two essential factors of mechanical strength and blood compatibility, as well as induce a micro-patterned surface...
October 24, 2016: Biofabrication
https://www.readbyqxmd.com/read/27775923/influence-of-synthesis-parameters-on-hyaluronic-acid-hydrogels-intended-as-nerve-conduits
#10
Isabel Ortuño-Lizarán, Guillermo Vilariño-Feltrer, Cristina Martínez-Ramos, Manuel Monleón Pradas, Ana Vallés-Lluch
Hydrogels have widely been proposed lately as strategies for neural tissue regeneration, but there are still some issues to be solved before their efficient use in tissue engineering of trauma, stroke or the idiopathic degeneration of the nervous system. In a previous work of the authors a novel Schwann-cell structure with the shape of a hollow cylinder was obtained using a three-dimensional conduit based in crosslinked hyaluronic acid as template. This original engineered tissue of tightly joined Schwann cells obtained in a conduit lumen having 400 μm in diameter is a consequence of specific cell-material interactions...
October 24, 2016: Biofabrication
https://www.readbyqxmd.com/read/27754980/development-of-tracer-tissue-roll-for-analysis-of-cellular-environment-and-response
#11
Darren Rodenhizer, Dan Cojocari, Bradly G Wouters, Alison P McGuigan
The tumour microenvironment is heterogeneous and consists of multiple cell types, variable extracellular matrix (ECM) composition, and contains cell-defined gradients of small molecules, oxygen, nutrients and waste. Emerging in vitro cell culture systems that attempt to replicate these features often fail to incorporate design strategies to facilitate efficient data collection and stratification. The tissue roll for analysis of cellular environment and response (TRACER) is a novel strategy to assemble layered, three-dimensional tumours with cell-defined, graded heterogeneous microenvironments that also facilitates cellular separation and stratification of data from different cell populations from specific microenvironments...
October 18, 2016: Biofabrication
https://www.readbyqxmd.com/read/27725343/3d-bioprinted-glioma-stem-cells-for-brain-tumor-model-and-applications-of-drug-susceptibility
#12
Xingliang Dai, Cheng Ma, Qing Lan, Tao Xu
Glioma is still difficult to treat because of its high malignancy, high recurrence rate, and high resistance to anticancer drugs. An alternative method for research of gliomagenesis and drug resistance is to use in vitro tumor model that closely mimics the in vivo tumor microenvironment. In this study, we established a 3D bioprinted glioma stem cell model, using modified porous gelatin/alginate/fibrinogen hydrogel that mimics the extracellular matrix. Glioma stem cells achieved a survival rate of 86.92%, and proliferated with high cellular activity immediately following bioprinting...
October 11, 2016: Biofabrication
https://www.readbyqxmd.com/read/27725340/free-floating-epithelial-micro-tissue-arrays-a-low-cost-and-versatile-technique
#13
P Flood, L Alvarez, E G Reynaud
Three-dimensional (3D) tissue models are invaluable tools that can closely reflect the in vivo physiological environment. However, they are usually difficult to develop, have a low throughput and are often costly; limiting their utility to most laboratories. The recent availability of inexpensive additive manufacturing printers and open source 3D design software offers us the possibility to easily create affordable 3D cell culture platforms. To demonstrate this, we established a simple, inexpensive and robust method for producing arrays of free-floating epithelial micro-tissues...
October 11, 2016: Biofabrication
https://www.readbyqxmd.com/read/27725338/toward-mimicking-the-bone-structure-design-of-novel-hierarchical-scaffolds-with-a-tailored-radial-porosity-gradient
#14
Andrea Di Luca, Alessia Longoni, Giuseppe Criscenti, Carlos Mota, Clemens van Blitterswijk, Lorenzo Moroni
Guiding bone regeneration poses still unmet challenges due to several drawbacks of current standard treatments in the clinics. A possible solution may rely on the use of three-dimensional scaffolds with optimized structural properties in combination with human mesenchymal stem cells (hMSCs). Bone presents a radial gradient structure from the outside, where the cortical bone is more compact (porosity ranging from 5% to 10%), toward the inner part, where the cancellous bone is more porous (porosity ranging from 50% to 90%)...
October 11, 2016: Biofabrication
https://www.readbyqxmd.com/read/27721222/quantifying-the-kinetics-and-morphological-changes-of-the-fusion-of-spheroid-building-blocks
#15
Michael J Susienka, Benjamin T Wilks, Jeffrey R Morgan
Tissue fusion, whereby two or more spheroids coalesce, is a process that is fundamental to biofabrication. We have designed a quantitative, high-throughput platform to investigate the fusion of multicellular spheroids using agarose micro-molds. Spheroids of primary human chondrocytes (HCH) or human breast cancer cells (MCF-7) were self-assembled for 24 h and then brought together to form an array comprised of two spheroids (one doublet) per well. To quantify spheroid fusogenicity, we developed two assays: (1) an initial tack assay, defined as the minimum amount of time for two spheroids to form a mechanically stable tissue complex or doublet, and (2) a fusion assay, in which we defined and tracked key morphological parameters of the doublets as a function of time using wide-field fluorescence microscopy over a 24 h time-lapse...
October 10, 2016: Biofabrication
https://www.readbyqxmd.com/read/27716641/a-versatile-method-for-combining-different-biopolymers-in-a-core-shell-fashion-by-3d-plotting-to-achieve-mechanically-robust-constructs
#16
Ashwini Rahul Akkineni, Tilman Ahlfeld, Anja Lode, Michael Gelinsky
Three-dimensional extrusion of two different biomaterials in a core/shell (c/s) fashion has gained much interest in the last couple of years as it allows for fabricating constructs with novel and interesting properties. We now demonstrate that combining high concentrated (16.7 wt%) alginate hydrogels as shell material with low concentrated, soft biopolymer hydrogels as core leads to mechanically stable and robust 3D scaffolds. Alginate, chitosan, gellan gum, gelatin and collagen hydrogels were utilized successfully as core materials-hydrogels which are too soft for 3D plotting of open-porous structures without an additional mechanical support...
October 7, 2016: Biofabrication
https://www.readbyqxmd.com/read/27716633/3d-printing-of-photocurable-poly-glycerol-sebacate-elastomers
#17
Yi-Cheun Yeh, Christopher B Highley, Liliang Ouyang, Jason A Burdick
Three-dimensional (3D) printed scaffolds have great potential in biomedicine; however, it is important that we are able to design such scaffolds with a range of diverse properties towards specific applications. Here, we report the extrusion-based 3D printing of biodegradable and photocurable acrylated polyglycerol sebacate (Acr-PGS) to fabricate scaffolds with elastic properties. Two Acr-PGS macromers were synthesized with varied molecular weights and viscosity, which were then blended to obtain photocurable macromer inks with a range of viscosities...
October 7, 2016: Biofabrication
https://www.readbyqxmd.com/read/27716629/ethical-considerations-in-the-translation-of-regenerative-biofabrication-technologies-into-clinic-and-society
#18
I A Otto, C C Breugem, J Malda, A L Bredenoord
Biofabrication technologies have the potential to improve healthcare by providing highly advanced and personalized biomedical products for research, treatment and prevention. As the combining of emerging techniques and integrating various biological and synthetic components becomes increasingly complex, it is important that relevant stakeholders anticipate the translation of biofabricated 3D tissue products into patients and society. Ethics is sometimes regarded as a brake on scientific progress, yet from our perspective, ethics in parallel with research anticipates societal impacts of emerging technologies and stimulates responsible innovation...
October 7, 2016: Biofabrication
https://www.readbyqxmd.com/read/27716628/a-comparison-of-different-bioinks-for-3d-bioprinting-of-fibrocartilage-and-hyaline-cartilage
#19
Andrew C Daly, Susan E Critchley, Emily M Rencsok, Daniel J Kelly
Cartilage is a dense connective tissue with limited self-repair capabilities. Mesenchymal stem cell (MSC) laden hydrogels are commonly used for fibrocartilage and articular cartilage tissue engineering, however they typically lack the mechanical integrity for implantation into high load bearing environments. This has led to increased interested in 3D bioprinting of cell laden hydrogel bioinks reinforced with stiffer polymer fibres. The objective of this study was to compare a range of commonly used hydrogel bioinks (agarose, alginate, GelMA and BioINK™) for their printing properties and capacity to support the development of either hyaline cartilage or fibrocartilage in vitro...
October 7, 2016: Biofabrication
https://www.readbyqxmd.com/read/27550945/differences-in-time-dependent-mechanical-properties-between-extruded-and-molded-hydrogels
#20
N Ersumo, C E Witherel, K L Spiller
The mechanical properties of hydrogels used in biomaterials and tissue engineering applications are critical determinants of their functionality. Despite the recent rise of additive manufacturing, and specifically extrusion-based bioprinting, as a prominent biofabrication method, comprehensive studies investigating the mechanical behavior of extruded constructs remain lacking. To address this gap in knowledge, we compared the mechanical properties and swelling properties of crosslinked gelatin-based hydrogels prepared by conventional molding techniques or by 3D bioprinting using a BioBots Beta pneumatic extruder...
August 22, 2016: Biofabrication
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