Benjamin Reineke, Ilona Paulus, Sophia Löffelsend, Chien-Hsin Yu, Dmitrii Vinogradov, Anna Meyer, Jonas Hazur, Jonas Röder, Madita Vollmer, Gültekin Tamgüney, Stephan Hauschild, Aldo R Boccaccini, Juergen Groll, Stephan Förster
Bioprinting has evolved into a thriving technology for the fabrication of cell-laden scaffolds. Bioinks are the most critical component for bioprinting. Recently, microgels have been introduced as a very promising bioink, enabling cell protection and the control of the cellular microenvironment. However, the fabrication of the bioinks involves the microfluidic production of the microgels, with a subsequent multistep process to obtain the bioink, which so far has limited its application potential. Here we introduce a direct coupling of microfluidics and 3D-printing for the continuous microfluidic production of microgels with direct in-flow printing into stable scaffolds...
March 12, 2024: Biofabrication