journal
MENU ▼
Read by QxMD icon Read
search

International Journal of Physiology, Pathophysiology and Pharmacology

journal
https://www.readbyqxmd.com/read/29218116/erratum-new-insights-and-new-hope-for-pulmonary-arterial-hypertension-natriuretic-peptides-clearance-receptor-as-a-novel-therapeutic-target-for-a-complex-disease
#1
Emmanuel Eroume-A Egom, Tiam Feridooni, Rebabonye B Pharithi, Barkat Khan, Haaris A Shiwani, Vincent Maher, Yassine El Hiani, Robert A Rose, Kishore Bs Pasumarthi, Hilaire A Ribama
[This corrects the article on p. 112 in vol. 9, PMID: 28951773.].
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29209453/statistical-methods-and-common-problems-in-medical-or-biomedical-science-research
#2
REVIEW
Fengxia Yan, Mayberry Robert, Yonggang Li
Statistical thinking is crucial for studies in medical and biomedical areas. There are several pitfalls of using statistics in these areas involving in experimental design, data collection, data analysis and data interpretation. This review paper describes basic statistical design problems in biomedical or medical studies and directs the basic scientists to better use of statistical thinking. The contents of this paper were based on previous literatures and our daily basic support work. It includes the sample size determination and sample allocation in experimental design stage, numerical and graphical data summarization, and statistical test methods as well as the related common errors at design and analytic stages...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29209452/protective-roles-of-hepatic-gaba-signaling-in-liver-injury
#3
Shuanglian Wang, Lu Zhang, Chuanyong Liu, Wei-Yang Lu
In addition to functioning as a neurotransmitter, γ-aminobutyric acid (GABA) generates signals, via its type A or type B receptors (GABAARs or GABABRs), in various types of cells. Studies, including ours, show that GABAAR-mediated auto- and paracrine GABAergic signaling occurs in rodent hepatocytes and cholangiocytes, protecting the liver against toxic injuries. This short article briefly introduces the GABA signaling system in rodent livers and discusses potential mechanisms by which the hepatic GABA signaling protects the liver function...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29209451/mir-149-reduces-while-let-7-elevates-asic1a-expression-in-vitro
#4
Yu-Qing Jiang, Xiang-Ming Zha
Acid-sensing ion channel 1a (ASIC1a) is the key subunit that determines acid-activated currents in neurons. ASIC1a is important for neural plasticity, learning, and for multiple neurological diseases, including stroke, multiple sclerosis, and traumatic injuries. These findings underline the importance for better defining mechanisms that regulate ASIC1a expression. During the past decade, microRNA has emerged as one important group of regulatory molecules in controlling protein expression. However, little is known about whether microRNA regulates ASIC1a...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29209450/zinc-chelation-promotes-streptokinase-induced-thrombolysis-in-vitro
#5
Zihui Wang, Xinge Yu, Yang V Li
Cardiovascular disorder occurs when a local blood clot obstructs an artery or a vein to its surround organs, causing related tissues to lose function and die. It is one of the leading causes of mortality and a major cause of disability. The effect of thrombolysis induced by injecting intravenous thrombolytic agents is critical for reducing tissue damages. Streptokinase (SK) is a widely used thrombolytic agent in the treatment of thromboembolism in the blood vessels. A high unit of streptokinase is used in thrombolytic therapies for thrombotic disorders and could improve tissue reperfusion...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/29209449/effect-of-oleanolic-acid-on-small-intestine-morphology-and-enzymes-of-glutamine-metabolism-in-diabetic-rats
#6
Murtala Bindawa Isah, Bubuya Masola
The small intestine (SI) is the main site for food absorption and glutamine utilization hence critical in metabolic disorders that involve energy balance such as diabetes. This study investigates the effects of oleanolic acid (OA) on SI morphology and some enzymes of glutamine metabolism in male Sprague-Dawley diabetic rats. High dose STZ-induced diabetes (HDD) and low dose STZ-induced diabetes (LDD) were induced by intraperitoneal injection of 60 and 40 mg streptozotocin/kg body weight respectively. Non-diabetic and diabetic rats were treated for two weeks with OA, insulin or OA + insulin in HDD study while animals in the in LDD study were treated with OA...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28951775/erratum-effects-of-low-dose-acetazolamide-on-exercise-performance-in-simulated-altitude
#7
Elisabeth Ernst, Hannes Gatterer, Johannes Burtscher, Martin Faulhaber, Elena Pocecco, Martin Burtscher
[This corrects the article on p. 28 in vol. 9, PMID: 28533889.].
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28951774/the-effect-of-epigallocatechin-3-gallate-on-the-renal-dysfunction-in-the-obstructed-kidney-in-the-rat
#8
Fayez T Hammad, Loay Lubbad
INTRODUCTION: Epigallocatechin-3-gallate (EGCG) is the most active catechin polyphenol extracted from the green tea. EGCG has protective effects in various renal and non-renal conditions. The aim of this study was to investigate the effect of EGCG on the alterations in renal functional parameters following reversible unilateral ureteral obstruction (UUO) in the rat. METHODS: Wistar rats underwent reversible left UUO for 72 hours. Group-EGCG (n=10) received intraperitoneal 50 mg/kg/day of EGCG whereas Group-Vx (n=10) had only normal saline...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28951773/new-insights-and-new-hope-for-pulmonary-arterial-hypertension-natriuretic-peptides-clearance-receptor-as-a-novel-therapeutic-target-for-a-complex-disease
#9
Emmanuel Eroume-A Egom, Tiam Feridooni, Rebabonye B Pharithi, Barkat Khan, Haaris A Shiwani BSc, Vincent Maher, Yassine El Hiani, Robert A Rose, Kishore Bs Pasumarthi, Hilaire A Ribama
BACKGROUND: Pulmonary Arterial Hypertension (PAH) is a deadly and disabling disease for which there is no marketed drug that addresses the underlying disease mechanism and targets to cure patients. The lack of understanding of the disease mechanism represents the main challenges in developing curative therapies. We here report, for the first time, that mice lacking natriuretic peptides clearance receptor develop PAH. METHODS AND RESULTS: Initial studies assessed cardiac structure and function in NPR-C(+/+) (wild type) and age matched, littermate NPR-C(-/-) mice by echocardiography...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28533892/malate-aspartate-shuttle-inhibitor-aminooxyacetic-acid-blocks-lipopolysaccharides-induced-activation-of-bv2-microglia
#10
Wangsong Shang, Xunbin Wei, Weihai Ying
NADH shuttles, including malate-aspartate shuttle (MAS) and glycerol-3-phosphate shuttle, mediate the transfer of the reducing equivalents of cytosolic NADH into mitochondria. In our current study, we used BV2 microglia as a cellular model to determine the roles of NADH shuttles in lipopolysaccharides (LPS)-induced microglial activation. We found that aminooxyacetic acid (AOAA), a widely used MAS inhibitor, significantly attenuated LPS-induced increases in the levels of nitric oxide-a hallmarker of microglial activation...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28533891/nuclear-uptake-of-an-amino-terminal-fragment-of-apolipoprotein-e4-promotes-cell-death-and-localizes-within-microglia-of-the-alzheimer-s-disease-brain
#11
Julia E Love, Ryan J Day, Justin W Gause, Raquel J Brown, Xinzhu Pu, Dustin I Theis, Chad A Caraway, Wayne W Poon, Abir A Rahman, Brad E Morrison, Troy T Rohn
Although harboring the apolipoprotein E4 (APOE4) allele is a well known risk factor in Alzheimer's disease (AD), the mechanism by which it contributes to disease risk remains elusive. To investigate the role of proteolysis of apoE4 as a potential mechanism, we designed and characterized a site-directed cleavage antibody directed at position D151 of the mature form of apoE4 and E3. Characterization of this antibody indicated a high specificity for detecting synthesized recombinant proteins corresponding to the amino acid sequences 1-151 of apoE3 and E4 that would generate the 17 kDa (p17) fragment...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28533890/effect-of-music-tempo-on-exercise-performance-and-heart-rate-among-young-adults
#12
Avinash E Thakare, Ranjeeta Mehrotra, Ayushi Singh
BACKGROUND & OBJECTIVES: Music captures attention, triggers a range of emotions, alters or regulates mood, increases work output, heightens arousal, induces states of higher functioning, reduces inhibitions and encourages rhythmic movement. Music has ergo-genic effect as well, it increases exercise performance, delays fatigue and increases performance and endurance, power and strength. Our study tried to evaluate the effect of music on exercise performance in young untrained subjects...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28533889/effects-of-low-dose-acetazolamide-on-exercise-performance-in-simulated-altitude
#13
Ernst Elisabeth, Gatterer Hannes, Burtscher Johannes, Faulhaber Martin, Pocecco Elena, Burtscher Martin
Preventive effects of acetazolamide (ACZ) on acute mountain sickness (AMS) are well established but effects on exercise performance at high altitude or in hypoxia have been less considered and are still inconsistent. We hypothesized that low-dose ACZ would not impair exercise performance at simulated high altitude. Thus, the aim of this study was to evaluate the interaction between low-dose ACZ and exercise performance in normobaric hypoxia. Sixteen subjects (8 males and 8 females) were randomly assigned either to receive low-dose ACZ (3×125 mg in 36 hours) or placebo...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28533888/neuroprotective-effects-of-melatonin-administration-against-chronic-immobilization-stress-in-rats
#14
Asmaa Ms Gomaa, Heba M Galal, Amal T Abou-Elgait
Chronic stress can impair brain functions and play a well-known role in the development of stress-related disorders such as anxiety. Melatonin (Mel) is a neurohormone which regulate several physiological processes including mood and behavior. This experimental study was designed to evaluate the effect of Mel on chronic immobilization stress (CIS) for 6 weeks in rats and to elucidate its possible underlying mechanisms. Twenty-eight adult male Wistar albino rats were divided into four equal groups: the control group, the Mel-treated group which was injected daily with Mel (10 mg/kg/day; IP) for 6 weeks, the stressed group which was subjected to CIS protocol daily for 6 weeks, and the Mel-treated stressed group which was injected with Mel and concurrently exposed to CIS protocol for 6 weeks...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28533887/lidocaine-suppresses-glioma-cell-proliferation-by-inhibiting-trpm7-channels
#15
Tiandong Leng, Suizhen Lin, Zhigang Xiong, Jun Lin
BACKGROUND: Malignant glioma is the most common brain cancer with devastating prognosis. Recurrence of malignant glioma following surgery is very common with few preventive and therapeutic options. Novel targets and therapeutic agents are constantly sought for better outcome. Our previous study established that inhibition of transient receptor potential melastatin 7 (TRPM7) channels resulted in significant decrease of human glioma cell growth and proliferation. As local anesthetic lidocaine has been shown to inhibit TRPM7 currents, we hypothesize that lidocaine may suppress glioma cell proliferation through TRPM7 channel inhibition...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28337311/consciousness-loss-during-epileptogenesis-implication-for-vlpo-pno-circuits
#16
REVIEW
Maohui Feng, Zhigang He, Baowen Liu, Zhixiao Li, Guorong Tao, Duozhi Wu, Hongbing Xiang
There is a growing concern about consciousness loss during epileptic seizures. Understanding neural mechanisms could lead to a better comprehension of cerebral circuit function in the control of consciousness loss in intractable epilepsy. We propose that ventrolateral preoptic area (VLPO)- PnO (nucleus pontis oralis) circuits may serve a major role in the loss of consciousness in drug-refractory epilepsy. Future behavioural and neuroimaging studies are clearly needed to understand the functional connectivity between the VLPO and PnO during loss of consciousness in drug-refractory epilepsy, to greatly prevent unconsciousness in this disorder and improve the quality of life in patients with intractable epilepsy...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28078056/proton-pump-inhibitor-induced-hypomagnesaemia-and-hypocalcaemia-case-review
#17
REVIEW
Jonathan Sivakumar
Proton pump inhibitor (PPI)-induced hypomagnesaemia is a rare but serious adverse effect of a widely prescribed medication. It has become an increasingly recognised complication since 2006, with the U.S. Food and Drug Administration issuing a warning for this risk with regards to long-term PPI use. We present the case of PPI-associated hypomagnesaemia and hypocalcaemia. A 91 year old male presented with tetany from severe hypomagnesaemia and hypocalcaemia. This condition occurred in the context of 18 months of PPI use, and resolved following cessation of PPI therapy and the replenishment of magnesium and calcium stores...
2016: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28078055/comparative-changes-in-antioxidant-enzymes-and-oxidative-stress-in-cardiac-fast-twitch-and-slow-twitch-skeletal-muscles-following-endurance-exercise-training
#18
Hayden W Hyatt, Ashley J Smuder, Kurt J Sollanek, Aaron B Morton, Michael D Roberts, Andreas N Kavazis
The aim of this study was to evaluate exercise-induced transcriptional and protein responses of heart, soleus (slow oxidative), and plantaris (fast glycolytic) muscle in response to ten days of endurance exercise training. Four-month old female Sprague-Dawley rats were assigned to either a sedentary (SED) or endurance exercise-training (EXE) group (n=8 per group). The heart, plantaris, and soleus were excised and used for biochemical analyses. Our results show that heart and plantaris from EXE animals had higher protein levels of superoxide dismutase 2 (SOD2) compared to SED animals (P<0...
2016: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28078054/the-effect-of-thymoquinone-on-the-renal-functions-following-ischemia-reperfusion-injury-in-the-rat
#19
Fayez T Hammad, Loay Lubbad
INTRODUCTION: The aim of this study was to investigate the effect of thymoquinone, an antioxidant phytochemical compound found in the plant Nigella sativa, on the alterations in renal functional parameters following warm renal ischemia-reperfusion injury (IRI) in the rat. METHODS: Wistar rats underwent left renal ischemia for 35 minutes. Group-TQ (n=15) received thymoquinone 10 mg/kg/day (dissolved in a vehicle (corn oil) orally by gavage starting 4 days prior to IRI and continued 6 days thereafter when the hemodynamic and tubular renal functions of the right and left kidneys were measured using clearance techniques...
2016: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28078053/amyloid-beta-peptide-22-35-induces-a-negative-inotropic-effect-on-isolated-rat-hearts
#20
Neda Yousefirad, Ziya Kaygısız, Yasemin Aydın
Evidences indicate that deposition of amyloid beta peptides (Aβs) plays an important role in the pathogenesis of Alzheimer disease. Aβs may influence cardiovascular system and ileum contractions. But the effect of amyloid beta peptide 22-35 (Aβ22-35) on cardiovascular functions and contractions of ileum has not been studied. Therefore, the present study aimed to investigate the possible effects of this peptide on isolated rat heart and ileum smooth muscle. Langendorff-perfused rat heart preparations were established...
2016: International Journal of Physiology, Pathophysiology and Pharmacology
journal
journal
42781
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"