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Journal of Diabetes Investigation

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https://www.readbyqxmd.com/read/29667360/menstrual-and-reproductive-factors-and-type-2-diabetes-risk-the-japan-public-health-center-based-prospective-study
#1
Akiko Nanri, Tetsuya Mizoue, Mitsuhiko Noda, Atsushi Goto, Norie Sawada, Shoichiro Tsugane
AIMS/INTRODUCTION: Menstrual and reproductive factors, including age at menarche, parity, and breastfeeding, have been linked to type 2 diabetes risk. We prospectively investigated the association between these factors and type 2 diabetes risk in a large Japanese cohort. MATERIALS AND METHODS: Participants were 37,511 women aged 45-75 years who participated in the baseline (1990-1993), second (1995-1998), and third surveys (2000-2003) of the Japan Public Health Center-based Prospective Study and who had no history of diabetes at the second survey...
April 18, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29667372/long-working-hours-and-skipping-breakfast-concomitant-with-late-evening-meals-are-associated-with-suboptimal-glycemic-control-among-young-male-japanese-patients-with-type-2-diabetes
#2
Yasushi Azami, Mitsuhiko Funakoshi, Hisashi Matsumoto, Akemi Ikota, Koichi Ito, Hisashi Okimoto, Nobuaki Shimizu, Fumihiro Tsujimura, Hiroshi Fukuda, Chozi Miyagi, Sayaka Osawa, Ryo Osawa, Jiro Miura
AIMS/INTRODUCTION: To assess the associations or working conditions, eating habits, and glycemic control among young Japanese workers with type 2 diabetes. MATERIALS AND METHODS: This hospital- and clinic-based prospective study included 352 male and 126 female working patients with diabetes aged 20-40 years. Data were obtained from June to July 2012 and June to July 2013. Logistic regression analysis was used to estimate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for suboptimal glycemic control (HbAlc level of ≥7%) obtained from June to July 2013...
April 17, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29660782/sglt2-inhibitor-induced-changes-in-body-composition-and-simultaneous-changes-in-metabolic-profile-52-week-prospective-light-study-with-luseogliflozin
#3
Takashi Sasaki, Masahiro Sugawara, Masahiro Fukuda
AIMS: It is unclear how changes in body composition induced by sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment correlate with metabolic profile changes. We aimed to clarify how metabolic profile changes correlate with body component changes, and if SGLT2 inhibitor treatment causes sarcopenia and bone mineral content (BMC) loss. MATERIALS AND METHODS: Moderately obese Japanese type 2 diabetes (T2D) patients, treated with luseogliflozin for a year, were observed prospectively and evaluated for body composition changes...
April 16, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29635733/renal-impairment-markers-in-type-2-diabetic-patients-with-different-types-of-hyperuricemia
#4
Zhongai Gao, Minxia Zuo, Fei Han, Xinxin Yuan, Mengdi Sun, Xiaochen Li, Ran Liu, Wenhui Jiang, Liyi Zhang, Baocheng Chang, Juhong Yang
AIMS/INTRODUCTION: Hyperuricemia (HUA) occurs because of decreased excretion of uric acid, increased synthesis of uric acid, or a combination of both mechanisms. The proportions of these three types of HUA in type 2 diabetic patients are not known. In the mean time, we assume that different types of HUA may manifest with different renal damage even in patients with normal renal filtration function. MATERIALS AND METHODS: We included 435 inpatients with type 2 diabetes in the Metabolic Disease Hospital of Tianjin Medical University from 2015 to 2016...
April 10, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29624902/one-hour-ogtt-plasma-glucose-at-gdm-diagnosis-is-a-common-predictor-of-the-need-for-insulin-therapy-in-pregnancy-and-postpartum-impaired-glucose-tolerance
#5
Takeshi Nishikawa, Keiko Ono, Shoko Hashimoto, Hiroyuki Kinoshita, Takuro Watanabe, Hirotaka Araki, Kae Otsu, Wakana Sakamoto, Masahiro Harada, Tetsushi Toyonaga, Shoichi Kawakami, Jyunichiro Fukuda, Yoshio Haga, Daisuke Kukidome, Takeshi Takahashi, Eiich Araki
AIMS/INTRODUCTION: Because gestational diabetes mellitus (GDM) is a risk for adverse perinatal outcomes, and patients with a history of GDM have an increased risk of impaired glucose tolerance (IGT). Here, we conducted two non-interventional and retrospective studies of GDM patients in Japan. MATERIALS AND METHODS: In the first study, we enrolled 529 GDM patients and assessed predictors of the need for insulin therapy. In the second study, we enrolled 185 patients from the first study, and assessed predictors of postpartum IGT...
April 6, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29624887/gpr119-agonist-ds-8500a-effects-on-pancreatic-%C3%AE-cells-in-japanese-type-2-diabetes-mellitus-patients
#6
Hirotaka Watada, Masanari Shiramoto, Shin Irie, Yasuo Terauchi, Yuichiro Yamada, Kazuhito Shiosakai, Yusuke Myobatake, Takashi Taguchi
INTRODUCTION: Pancreatic β-cell dysfunction contributes to type 2 diabetes mellitus (T2DM) progression. Drugs that improve insulin secretion may be a valuable treatment approach. This study aimed to evaluate the effect of the G protein-coupled receptor 119 agonist DS-8500a on insulin secretory capacity in Japanese T2DM patients. MATERIALS AND METHODS: This single-center, 4-week, randomized, double-blind, crossover study enrolled 21 Japanese drug-naïve T2DM patients aged ≥20 years with glycated hemoglobin ≥7...
April 6, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29607626/drug-fever-and-acute-inflammation-via-hypercytokinemia-triggered-by-dipeptidyl-peptidase-4-inhibitor-vildagliptin
#7
Takatoshi Anno, Hideaki Kaneto, Fumiko Kawasaki, Ryo Shigemoto, Yumi Aoyama, Kohei Kaku, Niro Okimoto
A 69-year-old man started taking dipeptidyl peptidase-4 inhibitor vildagliptin. One week later, C-reactive protein (CRP) and plasma immunoglobulin E levels were markedly elevated, and we stopped vildagliptin. After his laboratory findings were normalized, we challenged to re-start vildagliptin under the patient's agreement. Next day he had a high fever, and CRP and procalcitonin levels were elevated. Although we failed to find infection focus, we started antibiotics therapy. Two days later, high fever was improved, and CRP level was decreased...
April 1, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29607623/efficacy-and-safety-of-the-gpr119-agonist-ds-8500a-in-japanese-type-2-diabetes-mellitus-patients-with-inadequate-glycemic-control-on-sitagliptin-a-phase-2-randomized-placebo-controlled-study
#8
Yasuo Terauchi, Yuichiro Yamada, Hirotaka Watada, Yasuhiko Nakatsuka, Kazuhito Shiosakai, Takuo Washio, Takashi Taguchi
INTRODUCTION: We evaluated the efficacy and safety of DS-8500a as add-on therapy to sitagliptin in Japanese type 2 diabetes mellitus (T2DM) patients. MATERIALS AND METHODS: This multicenter, randomized, double-blind, placebo-controlled, phase 2 trial randomized patients aged ≥20 years with hemoglobin A1c ≥7.0% and <9.0% and inadequate glycemic control with sitagliptin 50-mg monotherapy to receive 25 or 75 mg DS-8500a, or placebo, orally. The primary endpoint was change from baseline to day 28 in 24-hour weighted mean glucose (WMG)...
April 1, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29603684/effects-of-a-novel-selective-peroxisome-proliferator-activated-receptor-%C3%AE-modulator-pemafibrate-k-877-on-hepatic-and-peripheral-glucose-uptake-in-patients-with-hypertriglyceridemia-and-insulin-resistance
#9
Ikuro Matsuba, Ren Matsuba, Shun Ishibashi, Shizuya Yamashita, Hidenori Arai, Koutaro Yokote, Hideki Suganami, Eiichi Araki
AIMS/INTRODUCTION: Pemafibrate (K-877) is a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα) with potent triglyceride (TG)-lowering and high-density lipoprotein cholesterol-raising effects. We showed that pemafibrate decreased the homeostasis model assessment for insulin resistance (HOMA-IR) in patients with dyslipidemia. To investigate how pemafibrate improves insulin sensitivity, we used a hyperinsulinemic-euglycemic clamp technique to determine the splanchnic and peripheral glucose uptake in patients with hypertriglyceridemia and insulin resistance...
March 30, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29582571/comprehensive-assessment-of-insulin-resistance-in-non-obese-asian-indian-and-chinese-men
#10
Hong Chang Tan, Tong Wei Yew, Shaji Chacko, E Shyong Tai, Jean-Paul Kovalik, Jianhong Ching, Sandi Myo Thant, Chin Meng Khoo
BACKGROUND: Asian Indians are more insulin resistant (IR) than Chinese even in non-obese BMI. However, BMI often underestimates body fat in Asian Indians and it remains unclear whether Asian Indians would remain more IR than Chinese when both BMI and body fat are equally matched. METHODS: Using the hyperinsulinemic-euglycemic clamp with stable-isotope infusion, we comprehensively assessed IR between 13 non-obese Asian Indians with 13 Chinese men matched for age, BMI and body fat...
March 27, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29582574/japanese-clinical-practice-guideline-for-diabetes-2016
#11
Masakazu Haneda, Mitsuhiko Noda, Hideki Origasa, Hiroshi Noto, Daisuke Yabe, Yukihiro Fujita, Atsushi Goto, Tatsuya Kondo, Eiichi Araki
No abstract text is available yet for this article.
March 26, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29575815/impact-of-age-at-menarche-on-obesity-and-glycemic-control-in-japanese-patients-with-type-2-diabetes-fukuoka-diabetes-registry
#12
Akiko Sumi, Masanori Iwase, Udai Nakamura, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Yuji Komorita, Masahito Yoshinari, Takanari Kitazono
AIMS/INTRODUCTION: A younger age at menarche is associated with obesity and type 2 diabetes in adult life. The impact of early onset menarche on obesity and glycemic control in type 2 diabetes has not been investigated. This study examined the relationship between age at menarche and obesity and glycemic control in type 2 diabetes. MATERIALS AND METHODS: A total of 2,133 patients with type 2 diabetes aged ≥20 years were divided into groups according to age at menarche (≤11 years, 12 years, 13 years, 14 years, and ≥15 years)...
March 25, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29575786/lactation-and-progression-to-type-2-diabetes-in-patients-with-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-cohort-studies
#13
Lijun Feng, Qunli Xu, Zhefang Hu, Hongying Pan
AIM: To explore the association between lactation and type 2 diabetes (T2DM) incidence in women with prior gestational diabetes (GDM). METHODS: We searched PubMed, Embase, and the Cochrane Library for cohort studies published through 12 June, 2017 that evaluated the effect of lactation on the development of T2DM in women with prior GDM. Random-effects model was used to estimate relative risks (RRs) with 95% confidence intervals (CIs). RESULTS: Thirteen cohort studies were included in the meta-analysis...
March 25, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29575757/-pro-renin-receptor-involvement-in-diabetic-retinopathy-and-development-of-molecular-targeted-therapy
#14
Atsuhiro Kanda, Susumu Ishida
The renin-angiotensin system (RAS), a crucial regulator of systemic blood pressure (circulatory RAS), plays distinct roles in pathological angiogenesis and inflammation in various organs (tissue RAS) such as diabetic microvascular complications. Using ocular clinical samples and animal disease models, we elucidated molecular mechanisms in which tissue RAS excites the expression of vascular endothelial growth factor (VEGF)-A responsible for retinal inflammation and angiogenesis, the two major pathological events in diabetic retinopathy (DR)...
March 25, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29575724/a-cross-sectional-survey-of-biosimilar-insulin-utilisation-in-asia-the-joint-asia-diabetes-evaluation-jade-programme
#15
Linsey Gani, Eric Lau, Andrea Luk, Leorino Sobrepena, Tran Quang Khanh, Jothydev Kesavadev, Weiping Jia, Weinan Yu, Chiu Chi Tsang, Mukhopadhyay Monojitketan, Sujeet Jha, Wayne Sheu, Kun Ho Yoon, Thy Khue Nguyen, Risa Ozaki, Wing Yee So, Christine Kwan, Amy W C Fu, Roberto Mirasol, Sanjeev Ratnakar Phatak, K M Prasanna Kumar, S R Aravind, Hari Janakiraman, Juliana Cn Chan
BACKGROUND: Biosimilar insulin may reduce treatment costs although its extent of usage is largely unknown. We examined biosimilar insulin use and its associations with quality of glycemic control using the JADE (Joint Asia Diabetes Evaluation) Register. METHODS: We conducted a cross-sectional analysis in 81,531 patients with type 1 and type 2 diabetes enrolled into the JADE Programme from 2007 to 2014. We extracted all insulin-related terms from the JADE portal and compared clinical profiles between biosimilar and originator insulin users...
March 25, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29573221/glycemic-extremes-are-related-to-cognitive-dysfunction-in-children-with-type-1-diabetes-a-meta-analysis
#16
Jing He, Andrew G Ryder, Shichen Li, Wanting Liu, Xiongzhao Zhu
AIMS: To examine the magnitude and pattern of cognitive dysfunction in children with type 1 diabetes and the possible effects associated with other disease variables, such as early onset diabetes, severe hypoglycemia and hyperglycemia. MATERIALS AND METHODS: We conducted a meta-analysis using the PRISMA guidelines. We searched MedLine, Embase, and PsycINFO to identify studies on cognitive function in children with type 1 diabetes that were published up until September 30th, 2016...
March 23, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29570955/human-pancreatic-alpha-to-beta-cell-area-ratio-increases-after-type-2-diabetes-onset
#17
Yukari Fujita, Junji Kozawa, Hiromi Iwahashi, Sho Yoneda, Sae Uno, Hidetoshi Eguchi, Hiroaki Nagano, Akihisa Imagawa, Iichiro Shimomura
AIMS/INTRODUCTION: Pancreatic alpha-cell area and the alpha- to beta-cell area ratio (α/β) might be associated with glucose tolerance. The aim was to clarify how these histological parameters change as glucose tolerance deteriorates. MATERIALS AND METHODS: We analyzed pancreatic tissues obtained from pancreatectomies in 43 patients. We evaluated the relationships between alpha-cell area or the α/β and various clinical parameters. Additionally, we analyzed alpha-cell proliferation and the expression patterns of various pancreatic transcription factors...
March 23, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29544027/the-molecular-clock-as-a-regulator-of-%C3%A3-cell-function
#18
EDITORIAL
Akihiko Taguchi, Yasuharu Ohta, Yukio Tanizawa
Type 2 diabetes mellitus is characterized by the loss of ß-cell function and mass, resulting from interactions between genetic predisposition and various environmental factors1 . One environmental condition identified as a risk factor for type 2 diabetes mellitus is circadian rhythm disruption, which is induced by shift work or sleep disturbance. However, the mechanism whereby circadian disruption leads to impaired glucose metabolism is not well understood. This article is protected by copyright. All rights reserved...
March 15, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29542288/non-high-density-lipoprotein-cholesterol-is-more-informative-than-traditional-cholesterol-indices-in-predicting-diabetes-risk-for-women-with-normal-glucose-tolerance
#19
Lu Liu, Qiu Li, Zhongshang Yuan, Meng Zhao, Xu Zhang, Haiqing Zhang, Dongmei Zheng, Jin Xu, Ling Gao, Qingbo Guan, Jiajun Zhao, Christopher G Proud, Xuemin Wang, Xu Hou
AIMS/INTRODUCTION: Limited data are available regarding the performance of non-high-density lipoprotein cholesterol (non-HDL) in predicting incident diabetes. We aimed to analyze the association between non-HDL and development of diabetes, and to estimate the cut-off point of non-HDL for discriminating incident diabetes in people with normal glucose tolerance (NGT). MATERIALS AND METHODS: Of 3653 middle aged and elderly Chinese with NGT at enrollment, 1,025 men and 1,805 women returned to the 3-year follow-up and involved in the fianl analysis...
March 14, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29542249/the-correlation-between-plasma-ferritin-level-and-gestational-diabetes-mellitus-and-its-impact-on-fetal-macrosomia
#20
Zhiguo Wang, Hai-Bo Fan, Wan-Wei Yang, Xiao-Dong Mao, Shu-Hang Xu, Xiao-Ping Ma, Gui-Ping Wan, Xiao-Ming Yao, Keyang Chen
AIMS/INTRODUCTION: To explore the relationship between plasma iron levels and gestational diabetes mellitus, as well as its impact on macrosomia. MATERIALS AND METHODS: We retrospectively compared ferritin level and other Characteristics between GDM gravidas and no-GDM gravidas. The correlation between the levels of plasma ferritin and glucose, Haemoglobin was explored. Meanwhile, we assessed the risk factors of macrosomia outcome. Furthermore, we explored the relationship between ferritin level and the incidence of macrosomia outcome...
March 14, 2018: Journal of Diabetes Investigation
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