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Journal of Diabetes Investigation

Kai-Jen Tien, Yi-Jen Hung, Jung-Fu Chen, Ching-Chu Chen, Chih-Yuan Wang, Chii-Min Hwu, Yu-Yao Huang, Pi-Jung Hsiao, Shih-Te Tu, Chao-Hung Wang, Wayne Huey-Herng Sheu
Diabetes remains a global epidemic problem and a tremendous health challenge especially in Asian population. Dramatic increases in the prevalence of diabetes across different countries or areas in Asia have been reported in recent epidemiological studies. While clinical guidelines have strengthen appropriate anti-hyperglycaemic medications and lifestyle modifications for optimal diabetes management, inadequate glycaemic control still occurs in many patients with an increased risk of developing microvascular and macrovascular complications...
December 6, 2018: Journal of Diabetes Investigation
Nobuyuki Takahashi, Daisuke Chujo
We compared the glucagon responses to arginine stimulation in five patients with fulminant type 1 diabetes and five age- and diabetes duration-matched acute-onset type 1 diabetes, and the curves of the glucagon responses were similar. In our study, we measured the glucagon levels by not only radioimmunoassay, but also novel enzyme-linked immunosorbent assay.
December 6, 2018: Journal of Diabetes Investigation
Fumika Mano, Kaori Ikeda, Yukiko Uchida, I-Ting Huai-Ching Liu, Erina Joo, Mizuyo Okura, Nobuya Inagaki
AIMS/INTRODUCTION: Recent evidence shows that cultural context can influence the management of diabetes mellitus. The aim of this study was to examine the relationship between interdependence, which is valued in the Eastern cultural context, and diabetes self-care behavior in Japanese patients with type 2 diabetes mellitus. MATERIAL AND METHODS: We conducted a cross-sectional survey of 161 Japanese adults with type 2 diabetes mellitus using well-established questionnaires...
December 5, 2018: Journal of Diabetes Investigation
Miho Shimizu, Kengo Furuichi, Tadashi Toyama, Tomoaki Funamoto, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Toshinari Takamura, Kiyoki Kitagawa, Mitsuhiro Yoshimura, Shuichi Kaneko, Hitoshi Yokoyama, Takashi Wada
AIMS/INTRODUCTION: This retrospective study investigated the impact of renal arteriosclerosis (AS) and hypertension (HT) on long-term renal and cardiovascular outcomes in Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy. MATERIALS AND METHODS: A total of 185 patients were enrolled. Patients were divided into four groups stratified by renal AS status and presence of HT. The outcomes for this study were the first occurrence of renal events (a need for dialysis or a 30% decline in estimated glomerular filtration rate from baseline) and cardiovascular events (cardiovascular death, nonfatal myocardial infarction, coronary intervention, or nonfatal stroke)...
December 5, 2018: Journal of Diabetes Investigation
Masato Furuhashi, Megumi Matsumoto, Takayo Murase, Takashi Nakamura, Yukimura Higashiura, Masayuki Koyama, Marenao Tanaka, Norihito Moniwa, Hirofumi Ohnishi, Shigeyuki Saitoh, Kazuaki Shimamoto, Tetsuji Miura
AIMS/INTRODUCTION: Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation in the purine metabolism, is involved in an increase in reactive oxygen species. Plasma XOR activity has been shown to be associated with obesity, smoking, liver dysfunction, hyperuricemia, dyslipidemia and insulin resistance. MATERIALS AND METHODS: The association between plasma XOR activity measured by using liquid chromatography and mass spectrometry and levels of adipokines, including adiponectin, fatty acid-binding protein 4 (FABP4) and fibroblast growth factor 21 (FGF21), were investigated in 282 subjects (male/female: 126/156) with no medication of the Tanno-Sobetsu Study...
December 5, 2018: Journal of Diabetes Investigation
Mitsuko Inoue, Akinori Hayashi, Tomomi Taguchi, Riina Arai, Sayaka Sasaki, Koji Takano, Yusuke Inoue, Masayoshi Shichiri
AIMS: Non-alcoholic fatty liver disease (NAFLD) is frequently associated with type 2 diabetes (T2D) and constitutes an important risk factor for the development of hepatic fibrosis and hepatocellular carcinoma. Because there remains no effective drug therapy for NAFLD associated with T2D, we evaluated the efficacy of sodium-glucose cotransporter 2 inhibitor (SGLT2i). METHODS AND MATERIALS: In this pilot, prospective non-randomized open-label single-arm study, we evaluated the effect of 100 mg canagliflozin administered once daily for 12 months on serological markers, body composition measured by bioelectrical impedance analysis method, and hepatic fat fraction (HFF) measured by magnetic resonance imaging, in T2D with NAFLD...
November 21, 2018: Journal of Diabetes Investigation
Shinji Kume, Shin-Ichi Araki, Satoshi Ugi, Katsutaro Morino, Daisuke Koya, Yoshihiko Nishio, Masakazu Haneda, Atsunori Kashiwagi, Hiroshi Maegawa
AIMS/INTRODUCTION: Diabetic kidney disease is characterized by increased albuminuria and/or a reduced glomerular filtration rate (GFR). We analyzed secular changes in the prevalence of albuminuria and reduced estimated GFR (eGFR) in Japanese patients with type 2 diabetes and identified factors associated with these changes. MATERIALS AND METHODS: Using the 1996, 2001, 2006, and 2014 cohort data from the Japanese serial cross-sectional studies conducted at Shiga University of Medical Science, secular changes in the prevalence of diabetic kidney disease (DKD) (albuminuria and/or reduced eGFR), patient characteristics, and their associations were analyzed...
November 19, 2018: Journal of Diabetes Investigation
Satoko Shimazu-Kuwahara, Yoshinori Kanemaru, Norio Harada, Eri Ikeguchi, Yohei Ueda, Shunsuke Yamane, Yuki Murata, Akihiro Yasoda, Timothy J Kieffer, Nobuya Inagaki
Given the established roles of glucose-dependent insulinotropic polypeptide (GIP) in promoting fat storage and bone formation, we assessed the contribution of GIP to obesity and osteopenia in ovariectomized mice with a gene encoding green fluorescent protein (GFP) inserted into the GIP locus, in which GIP was either reduced (GIPgfp/+ ) or absent (GIPgfp/gfp ). In GIPgfp/gfp mice, weight gain, subcutaneous and visceral fat mass were reduced and glucose intolerance was improved compared to wild-type (WT) mice with the same magnitude of insulin responses...
November 19, 2018: Journal of Diabetes Investigation
Yi Wang, Changjun Lan, Xuan Liao, Di Chen, Wengang Song, Qiuling Zhang
AIMS/INTRODUCTION: To investigate the protective effect of polygonati sibiricum polysaccharide (PSP) on the retina in diabetic rats. MATERIALS AND METHODS: A total of 120 SD rats were randomly divided into blank control (BC), model control meaning diabetic mellitus (DM), and DM with PSP intervention of high (H), medium (M) and low (L) doses groups. The difference of retinal vascularization between groups was evaluated by fluorescein isothiocyanate-dextran (FITC-dextran) perfusion...
November 13, 2018: Journal of Diabetes Investigation
Xinwen Yu, Li Wang, Wencheng Zhang, Jie Ming, Aihua Jia, Shaoyong Xu, Qiaoyue Li, Qiuhe Ji
AIMS: Metabolic unhealth can be defined by the components of metabolic syndrome (MetS), which is closely connected to insulin resistance (IR). We aim to determine a simple index to identify the metabolic unhealth of the Chinese adult population. METHODS: A total of 30,291 individuals were screened from the China National Diabetes and Metabolic Disorders Study conducted from June 2007 to May 2008. Metabolic unhealth was defined using components of MetS, except waist circumference (WC)...
November 11, 2018: Journal of Diabetes Investigation
Shohei Matsuno, Hiroto Furuta, Kitaro Kosaka, Asako Doi, Tohru Yorifuji, Takuya Fukuda, Takafumi Senmaru, Shinsuke Uraki, Norihiko Matutani, Machi Furuta, Hiroyuki Mishima, Hiroshi Iwakura, Masahiro Nishi, Kohichiro Yoshiura, Michiaki Fukui, Takashi Akamizu
Whole-exome sequencing is a new technology. We used it to explore the gene responsible for early-onset diabetes due to impaired insulin secretion in a family. In the INS gene, we identified the heterozygous c.188-31G>A mutation in the proband. The mutation was also identified in her two daughters with diabetes, but not in her son or her parents, all of whom were not diabetic. The substitution was located 31 bp proximal to exon three in the intron two. It was predicted to create an ectopic splice site leading to insert 29 nucleotides of intron two as an exonic sequence in the transcript...
November 10, 2018: Journal of Diabetes Investigation
Takashi Kadowaki, Masaomi Nangaku, Stefan Hantel, Tomoo Okamura, Maximilian von Eynatten, Christoph Wanner, Audrey Koitka-Weber
AIMS/INTRODUCTION: In the EMPA-REG OUTCOME® trial, empagliflozin added to standard of care improved clinically relevant kidney outcomes by 39%, slowed progression of chronic kidney disease, and reduced albuminuria in patients with type 2 diabetes and established cardiovascular disease. This exploratory analysis investigated kidney effects of empagliflozin in Asian patients. MATERIALS AND METHODS: Participants in EMPA-REG OUTCOME® were randomized (1:1:1) to empagliflozin 10 mg, 25 mg, or placebo...
November 9, 2018: Journal of Diabetes Investigation
Yuko Murase-Mishiba, Megumi Bessho-Tachibana, Akihisa Imagawa
Mixed-meal tolerance tests were carried out after an overnight fast. Healthy control participants (■), type 1A diabetespatients (○) and fulminant type 1 diabetic patients (▲). Data are presented as the mean ± standard error of the mean.
November 9, 2018: Journal of Diabetes Investigation
Ching-Ju Chiu, Ye-Fong Du
AIMS/INTRODUCTION: The present study investigated the longitudinal associations between depressive symptoms and glycemic control in nationally representative adults with type 2 diabetes, and tested the effects of sex and perceived family support in moderating this association. MATERIALS AND METHODS: In this longitudinal study of middle-aged and older adults who participated in the 2002 and 2006 Health and Retirement Study, and the 2003 and 2006 Diabetes Study (n = 398), we applied a cross-lagged structural equation model to examine the reciprocal relationship between depressive symptoms and glycemic control over a 3-year period...
November 3, 2018: Journal of Diabetes Investigation
Ryo Kumagai, Aiko Muramatsu, Masanao Fujii, Yukino Katakura, Kei Ito, Keiko Fujie, Yoshio Nakata, Koichi Hashimoto, Hiroaki Yagyu
AIMS/INTRODUCTION: Flash (FGMS) and continuous (CGMS) glucose monitoring systems are becoming prevalent in clinical practice. We directly compared FGMS (FreeStyle Libre-Pro, FSL-Pro) with CGMS (iPro2) in patients with diabetes mellitus (DM). MATERIALS AND METHODS: Glucose concentrations were simultaneously measured using the FSL-Pro, iPro2 and self-monitoring blood glucose (SMBG) in ten patients with DM and agreement among them was assessed. RESULTS: Parkes error grid analysis revealed that the 92...
November 3, 2018: Journal of Diabetes Investigation
Takanori Honda, Hiro Kishimoto, Naoko Mukai, Jun Hata, Daigo Yoshida, Yoichiro Hirakawa, Mao Shibata, Tomoyuki Ohara, Shuzo Kumagai, Toshiharu Ninomiya
AIM/INTRODUCTION: This study aimed to examine cross-sectional associations between objectively measured sedentary time and prevalence of diabetes mellitus in a general Japanese population, and to elucidate possible mediating roles of diet, obesity, and insulin resistance in this relationship. MATERIALS AND METHODS: A total of 1,758 community-dwellers aged 40-79 years wore an accelerometer for ≥7 days and underwent a comprehensive health examination in 2012. Diabetes mellitus was diagnosed by a 75-g oral glucose tolerance test...
November 2, 2018: Journal of Diabetes Investigation
Weerachai Srivanichakorn, Ian F Godsland, Chaiwat Washirasaksiri, Pochamana Phisalprapa, Phunchai Charatcharoenwitthaya, Pornpoj Pramyothin, Tullaya Sitasuwan, Lukana Preechasuk, Robert Elkeles, K George Mm Alberti, Desmond G Johnston, Nick S Oliver
AIMS/INTRODUCTION: Relationships between cardiometabolic risk and glycemia have rarely been studied in people under clinical evaluation and treatment for cardiometabolic risk and with prediabetes. We investigated relationships between glycemia and cardiometabolic risk factors in clinic participants with prediabetes. MATERIALS AND METHODS: This was a cross-sectional analysis of data collected at a center in Thailand. Clinic attendees were at high risk of diabetes or cardiovascular disease, with hemoglobin A1c (HbA1c) 39-<48 mmol/mol or fasting plasma glucose (FPG) 5...
November 2, 2018: Journal of Diabetes Investigation
Takashi Sasaki
The paper provides the issues regarding the body composition change by sodium-glucose cotransporter 2 inhibitors.
October 27, 2018: Journal of Diabetes Investigation
Kumi Kimura, Yuka Inaba, Hitoshi Watanabe, Toshiya Matsukawa, Michihiro Matsumoto, Inoue Hiroshi
AIMS/INTRODUCTION: Nonalcoholic steatohepatitis (NASH), which occurs in association with insulin resistance and hepatic fat accumulation, is characterized by chronic liver injury and fibrosis. NASH onset and progression is closely related to hepatic inflammation, which is partly regulated by the vagus nerve through the α7 nicotinic acetylcholine receptor (α7nAchR). Hepatic α7nAchR action is impeded in obesity and insulin resistance. In this study, using α7nAchR knockout (α7KO) mice, we elucidated the effect of α7nAchR deficiency on NASH-related inflammation and fibrosis...
October 27, 2018: Journal of Diabetes Investigation
Ryuta Nomiyama, Masahiro Emoto, Naofumi Fukuda, Kumiko Matsui, Manabu Kondo, Ayuko Sakane, Takuya Sasaki, Yukio Tanizawa
AIMS/INTRODUCTION: DOC2b (double C2 domain protein b), one of the synaptotagmins, has been shown to translocate to the plasma membrane, and to initiate membrane-fusion processes of vesicles containing glucose transporter 4 (GLUT4) proteins upon insulin stimulation. However, the mechanism by which DOC2b is regulated remains unclear. Herein, we identified the upstream regulatory factors of DOC2b in insulin signal transduction. We also examined the role of DOC2b on systemic homeostasis using DOC2b knockout (KO) mice...
October 27, 2018: Journal of Diabetes Investigation
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