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Journal of Diabetes Investigation

Shuhei Nakanishi, Hidenori Hirukawa, Masashi Shimoda, Fuminori Tatsumi, Kenji Kohara, Atsushi Obata, Tomohiko Kimura, Seizo Okauchi, Tomoe Kinoshita, Junpei Sanada, Yoshiro Fushimi, Momoyo Nishioka, Akiko Mizoguchi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
AIMS/INTRODUCTION: This study examined the association between the onset of micro- and macroangiopathy in type 2 diabetes subjects (T2DM) and levels of HbA1c described in "Evidence-based Practice Guideline for the Treatment for Diabetes in Japan 2013" (KD) or those indicated in "the Japan Diabetes Society and the Japan Geriatrics Society Joint Committee on Improving Care for Elderly Patients with Diabetes" (JDS/JGS). MATERIALS AND METHODS: Eligible for this study were T2DM who visited the outpatient clinic at Kawasaki Medical School Hospital between 2000 and 2016 and received follow-up for more than two years...
August 12, 2018: Journal of Diabetes Investigation
Daisuke Yabe, Atsutaka Yasui, Linong Ji, Moon-Kyu Lee, Ronald Ching Wan Ma, Tien-Jyun Chang, Tomoo Okamura, Cordula Zeller, Stefan Kaspers, Jisoo Lee, Sven Kohler, Yutaka Seino
AIMS/INTRODUCTION: We investigated the safety and tolerability of empagliflozin (EMPA) in East Asian patients with type 2 diabetes (T2D). MATERIALS AND METHODS: Data were pooled from participants with T2D evenly randomized to placebo, EMPA 10 mg, or EMPA 25 mg in 15 Phase I-III trials. Adverse events (AEs) were analyzed in the subgroup of trial participants from East Asian countries/regions. RESULTS: In total, 709, 724 and 708 East Asian trial participants with T2D received placebo, EMPA 10 mg and EMPA 25 mg, respectively; total exposure was 953, 1072, and 1033 patient-years in these groups, respectively...
August 12, 2018: Journal of Diabetes Investigation
Bo Ahrén
GLP-1 receptor agonists are today established glucose-lowering drugs in the management of type 2 diabetes. Their development emerged from the understanding that a combined islet dysfunction comprising of impaired insulin secretion and exaggerated glucagon secretion is the key defect for the hyperglycemia. GLP-1 was early shown to target these defects and following the realization that DPP-4 inactivates native GLP-1, several different DPP-4 resistant GLP-1 receptor agonists have been developed. They are administered subcutaneously but show differences in molecular structure, molecular size and pharmacokinetics, the latter allowing twice daily, once daily or once weekly administration...
August 12, 2018: Journal of Diabetes Investigation
Yuki Fukuoka, Takuma Narita, Hiroki Fujita, Tsukasa Morii, Takehiro Sato, Mariko Harada Sassa, Yuichiro Yamada
AIMS/INTRODUCTION: To investigate the prevalence of sarcopenia, its related factors, and indicators of physical evaluation in elderly diabetic patients. MATERIALS AND METHODS: This was a cross-sectional observation study. Total 267 diabetic patients (159 men, 108 women) aged > 65 years were recruited in our study. Skeletal muscle mass index, grip strength, and usual gait speed were measured to diagnose sarcopenia according to the Asian Working Group for Sarcopenia...
August 11, 2018: Journal of Diabetes Investigation
Masatoshi Murase, Yusuke Seino, Ryuya Maekawa, Atsushi Iida, Kaori Hosokawa, Tomohide Hayami, Shin Tsunekawa, Yoji Hamada, Norihide Yokoi, Susumu Seino, Yoshitaka Hayashi, Hiroshi Arima
AIM/INTRODUCTION: High carbohydrate diet is known to increase insulin secretion and induce obesity. However, whether or not high carbohydrate diet affects β-cell mass has been little investigated. MATERIALS AND METHODS: Both wild-type (WT) mice and KATP channel deficient (Kir6.2KO) mice were fed normal chow (NC) or high-starch (ST) diets for 22 weeks. β-cell mass and the numbers of islets were analyzed by immunohistochemistry, and gene expression levels in islets were investigated by quantitative real-time RT-PCR...
August 7, 2018: Journal of Diabetes Investigation
Xiang Li, Zhangrong Xu, Linong Ji, Lixin Guo, Jing Liu, Kun Feng, Yushan Xu, Dalong Zhu, Weiping Jia, XinWu Ran, Limin Chen, Shi Zhao, Bingying Shi, Jun Zhu, Zongyan Shan, Zhiguang Zhou, Longyi Zeng, Jianping Weng
AIMS/INTRODUCTION: To investigate the direct medical costs for patients with type 2 diabetes in China and to examine the influencing factors. MATERIALS AND METHODS: In this multicenter study, 1070 patients with type 2 diabetes from sixteen tertiary hospitals in fourteen major cities of China were enrolled. Patient data and direct medical costs were collected during a follow-up period of six months at intervals of one month. The log-transformed direct medical costs were fiwere by generalized estimation equation to indicator variables for demographics, metabolic control, treatments, complications and comorbidities...
August 5, 2018: Journal of Diabetes Investigation
Takahiro Takase, Akinobu Nakamura, Chiho Yamamoto, Hiroshi Nomoto, Aika Miya, Midori Dannoura, Kyu Yong Cho, Yoshio Kurihara, Naoki Manda, Shin Aoki, Tatsuya Atsumi, Hideaki Miyoshi
AIMS/INTRODUCTION: We compared treatment satisfaction in type 2 diabetes patients taking daily and weekly glucagon-like peptide-1 (GLP-1) receptor agonists. MATERIALS AND METHODS: The study was a 12-week, multicenter, open-label, prospective, randomized, parallel-group comparison trial. The participants were Japanese patients with type 2 diabetes being administered with the GLP-1 receptor agonist liraglutide daily for more than 3 months. Patients were randomly assigned to either continue taking liraglutide once daily (Lira group) or to switch to dulaglutide once weekly (Dula group)...
August 4, 2018: Journal of Diabetes Investigation
Tadashi Yamakawa, Rika Sakamoto, Kenichiro Takahashi, Jun Suzuki, Minori Matuura-Shinoda, Mayumi Takahashi, Erina Shigematsu, Shunichi Tanaka, Mizuki Kaneshiro, Taro Asakura, Takehiro Kawata, Yoshihiko Yamada, Uru Nezu Osada, Tetsuo Isozaki, Atsushi Takahashi, Kazuaki Kadonosono, Yasuo Terauchi
AIM/INTRODUCTION: This study investigated the relationship between macronutrient energy ratio, dietary carbohydrate, and glycated hemoglobin levels in Japanese patients with type 2 diabetes, to generate a potential optimal dietary intake of macronutrients for such patients. MATERIALS AND METHODS: In total, 3032 patients participating in the SOREKA study were evaluated. Their diets were assessed for macronutrient content through a brief self-administered dietary history questionnaire...
August 1, 2018: Journal of Diabetes Investigation
Yali Jing, Qingmin Sun, Xiaolu Xiong, Ran Meng, Sunyinyan Tang, Shu Cao, Yan Bi, Dalong Zhu
AIMS/INTRODUCTION: Type 2 diabetes mellitus (T2DM) is frequently accompanied by fatty liver disease. Lipid accumulation within the liver is considered as one of the risk factors for insulin resistance. Hepatocyte growth factor (HGF) is used to treat liver dysfunction, however the effect and mechanism of HGF on hepatic lipid metabolism is still not fully understood. MATERIALS AND METHODS: Male C57BL/6 mice were induced with high-fat diet (HFD) for 12 weeks, followed by a four-week treatment of HGF or vehicle saline...
August 1, 2018: Journal of Diabetes Investigation
Zhengyue Jing, Jie Chu, Zerin Imam Syeda, Xinyi Zhang, Qiongqiong Xu, Long Sun, Chengchao Zhou
AIMS/INTRODUCTION: Diabetes Mellitus often causes high economic burden on the patients and their households. This study aims to assess the incidence and intensity of catastrophic health expenditure (CHE) relating to type 2 diabetes mellitus (DM) care and explore its determinants in China. MATERIALS AND METHODS: A total of 1948 type 2 diabetic patients were included in the analysis. CHE for type 2 DM was defined as the out of pocket (OOP) payments for diabetic care equaled or exceeded 40% of non-food expenditure of a household...
July 25, 2018: Journal of Diabetes Investigation
Xin Zhang, Xiaoxiao Chen, Weiwei Gong
BACKGROUND: Most studies reported socioeconomically disadvantaged people or people live in the deprived areas were more vulnerable to diabetes problems. However, few such studies were explored in China. This study is to examine the spatial association between T2DM incidence and neighbourhood deprivation in Zhejiang from spatial epidemiology perspective. METHODS: T2DM data (2012-2016) in this study derived from a population-based diabetes registry system maintained by Zhejiang Provincial Centre for Disease Control and Prevention (Zhejiang CDC)...
July 24, 2018: Journal of Diabetes Investigation
Megumi Shiomi, Tesshu Takada, Yoichi Tanaka, Keiko Yajima, Akira Isomoto, Masaki Sakamoto, Katsuya Otori
AIM/INTRODUCTION: Research has proved a correlation between glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and gastrointestinal (GI) adverse events (AEs). Predominantly, nausea and vomiting are frequent GI AEs that lead to the discontinuation of GLP-1 RAs treatment. This study aims to investigate clinical factors related to nausea and vomiting, considering diabetic complications and agents affecting the GI tract, such as proton-pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs), in patients with type 2 diabetes treated with GLP-1 RAs...
July 23, 2018: Journal of Diabetes Investigation
Jing Li, Yun-Feng Cao, Xiao-Yu Sun, Liang Han, Sai-Nan Li, Wen-Qing Gu, Min Song, Chang-Tao Jiang, Xilin Yang, Zhong-Ze Fang
OBJECTIVE: Metabolomic markers have the potential to improve the predicting accuracy of existing risk scores for type 2 diabetes (T2DM). This study aimed to test associations between plasma tyrosine and T2DM with special attention to identifying possible cutoff points for T2DM, and its interactive effects with low high-density lipoprotein cholesterol (HDL-C) or/and high triglyceride for T2DM. METHODS: From May 27, 2015, to August 3, 2016, we retrieved medical notes of 1898 in-patients with T2DM as the cases and 1522 subjects without diabetes as the controls who attended annual medical check-ups from the same tertiary care center in Jinzhou, China...
July 12, 2018: Journal of Diabetes Investigation
Haibin Wu, Karen N Eggleston, Jieming Zhong, Ruying Hu, Chunmei Wang, Kaixu Xie, Yiwei Chen, Xiangyu Chen, Min Yu
INTRODUCTION/AIMS: To evaluate the annual direct medical cost attributable to type 2 diabetes mellitus (T2DM) according to socioeconomic factors, medical conditions and complications categories. MATERIALS AND METHODS: We created uniquely detailed data from merging datasets of local diabetes management system and social security system in Tongxiang, China. We calculated T2DM-related total cost and out-of-pocket (OOP) cost for inpatient admissions and outpatient visits, and compared the cost for patients with or without complications by different health-care items...
July 11, 2018: Journal of Diabetes Investigation
Tomonori Hasegawa, Miho Komagata, Akihiro Hamasaki, Norio Harada, Yutaka Seino, Nobuya Inagaki
AIMS: It is reported that the interfering substances in the blood may influence the value for measurement of active GLP-1 in human plasma. Solid phase extraction (SPE) pretreatment is recommended to reduce their influence, but it requires a lot of cost and time. However, there is little investigation about causative inhibitory substances and about methods that can replace solid phase extraction. In this study, we aimed to seek the candidate of the substances that may interfere with an active GLP-1 enzyme-linked immunosorbent assay (ELISA)...
July 11, 2018: Journal of Diabetes Investigation
Mizuho Yamabe, Mami Kuroda, Yasuyo Hirosawa, Hiromi Kamino, Haruya Ohno, Masayasu Yoneda
AIMS/INTRODUCTION: We compared the efficacy and safety of insulin glargine 300 U/mL (Gla300) and insulin degludec U100 (Deg) using a flash glucose monitoring (FGM) system. MATERIALS AND METHODS: Twenty-four Japanese patients with type 2 diabetes were randomized to receive once-daily Gla300 (n = 12) or Deg (n = 12) in the morning. The primary endpoints were the mean percentage of time in the target glucose range (70-179 mg/dL) and hypoglycemia (< 70 mg/dL), as measured using FGM during the last 7 days of each 14-day period...
July 10, 2018: Journal of Diabetes Investigation
Kenta Nakano, Rieko Yanobu-Takanashi, Yuki Takahashi, Hayato Sasaki, Yukiko Shimizu, Tadashi Okamura, Nobuya Sasaki
AIMS/INTRODUCTION: Diabetic animal models have made an enormous contribution to our understanding of the etiology of diabetes and the development of new medications. The aim of this study was to develop and characterize a novel, non-obese murine strain with spontaneous diabetes, the insulin hyposecretion (ihs) mouse. MATERIALS AND METHODS: During the development of ICGN.B6-Tns2WT  strain as the control for ICGN-Tns2nph  congenital nephrotic strain, diabetic mice were discovered and named ihs mice...
July 10, 2018: Journal of Diabetes Investigation
Tatsuya Kondo, Nobukazu Miyakawa, Hiroyuki Motoshima, Satoko Hanatani, Norio Ishii, Motoyuki Igata, Kayo Yoshinaga, Daisuke Kukidome, Takafumi Senokuchi, Junji Kawashima, Noboru Furukawa, Takeshi Matsumura, Eiichi Araki
AIMS/INTRODUCTION: On April 14 and 16 2016, the Kumamoto area was severely damaged by several massive magnitude 7 class earthquakes. MATERIALS AND METHODS: To examine the effects of these earthquakes on glycemic control and stress factors, glycated hemoglobin, glycated albumin, other biochemical parameters, a self-administered lifestyle-associated questionnaire and disaster-associated stress scores were analyzed. A total of 557 patients with diabetes were enrolled, and data were collected at 13 months before to 13 months after the earthquakes...
July 6, 2018: Journal of Diabetes Investigation
Hiroaki Masuzaki, Chisayo Kozuka, Shiki Okamoto, Masato Yonamine, Hideaki Tanaka, Michio Shimabukuro
Chronic overconsumption of animal fats causes a variety of health problems including diabetes mellitus and obesity disease. Underlying molecular mechanisms encompass leptin resistance, decrease in rewarding effects of physical activities, xanthine oxidase-induced oxidative stress in vasculature and peripheral tissue, impaired activation of incretin signaling, deviation in food preference and dysbiosis of gut microbiota. Based on our clinical observation that dairy intake of brown rice effectively ameliorates body weight gain, impaired glucose tolerance / insulin resistance and dependence on fatty foods in obese, pre-diabetic men, a line of research on brown rice (rice bran)-derived γ-oryzanol in mice experiments, cultured cells and human clinical trials is underway in our laboratory...
July 6, 2018: Journal of Diabetes Investigation
Kazuki Yasuda
The worldwide prevalence of obesity keeps growing, especially in Asian and African countries, but pharmacological treatment of obesity remains a huge challenge. Surgical intervention, known as bariatric surgery, achieves dramatic and sustained body weight loss in morbidly obese subjects; concomitantly, it results in substantial improvement of obesity-related comorbidities, especially diabetes mellitus, as many diabetic patients can reach "complete remission" (HbA1c <6% without medication). Based on this observation, the term "metabolic surgery" was generated...
July 6, 2018: Journal of Diabetes Investigation
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