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Journal of Diabetes Investigation

Hitoshi Ishii, Yasuaki Hayashino, Yasuhiro Akai, Matahiro Yabuta, Satoru Tsujii
AIMS/INTRODUCTION: To compare the treatment satisfaction of four classes of oral hypoglycemic agents (OHAs): dipeptidyl peptidase-4 (DPP-4) inhibitors, α-glucosidase inhibitors (αGI), biguanides (BG), and sulfonylureas (SU), which are common initial treatments for type 2 diabetes mellitus patients in Japan, and to identify the best OHA in terms of treatment satisfaction. MATERIALS AND METHODS: In this 12-week, randomized, controlled, open-label study, Japanese outpatients with type 2 diabetes mellitus who were naïve to pharmacological treatment were randomly assigned a DPP-4 inhibitor, a BG, an αGI, or a SU...
March 14, 2017: Journal of Diabetes Investigation
Takuo Nomura, Tomoyasu Ishiguro, Masayoshi Ohira, Yukio Ikeda
AIMS/INTRODUCTION: The present study elucidated the effect of diabetic polyneuropathy (DPN) on lower extremity strength in a wide age range of type 2 diabetic patients. MATERIALS AND METHODS: Participants (n = 1,442) were divided into three age groups (30-49 years, 50-69 years, and 70-87 years), and comparisons were made separately for each sex. Lower extremity strength was measured in terms of knee extension force (KEF) with a hand-held dynamometer. KEF was compared according to the presence or absence of DPN...
March 14, 2017: Journal of Diabetes Investigation
Tomoaki Morioka, Masanori Emoto, Yuko Yamazaki, Masafumi Kurajoh, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Tetsuo Shoji, Masaaki Inaba
AIMS/INTRODUCTION: A soluble form of the leptin receptor (soluble Ob-R) in circulation regulates leptin's bioactivity and is inversely associated with body adiposity and circulating leptin levels. However, no study has examined the clinical impact of soluble Ob-R on glucose metabolism in diabetes. This study aimed to investigate the association of plasma soluble Ob-R levels with insulin resistance and pancreatic β-cell function in patients with type 2 diabetes. MATERIALS AND METHODS: Two hundred and eighty nine Japanese patients with type 2 diabetes were included in this study...
March 14, 2017: Journal of Diabetes Investigation
Bin Wu, Suhua Zhang, Houwen Lin, Shan Mou
AIMS: Diabetic kidney disease (DKD) is the second leading cause (16.4%) of end-stage renal disease (ESRD) in China. The current study is to assess the cost effectiveness of preventing DKD in patients with newly diagnosed type 2 diabetes (T2DM) from the Chinese health care perspective. METHODS: A lifetime Markov decision model was developed according to the disease course of DKD. Patients with newly diagnosed T2DM might receive treatment according to one of the following three strategies: "do nothing" strategy (control strategy), treatment with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) (universal strategy), or screening for microalbuminuria followed by ACEI/ARB treatment (screening strategy)...
March 10, 2017: Journal of Diabetes Investigation
Aika Miya, Akinobu Nakamura, Hideaki Miyoshi, Kyu Yong Cho, So Nagai, Yoshio Kurihara, Shin Aoki, Masataka Taguri, Yasuo Terauchi, Tatsuya Atsumi
AIMS/INTRODUCTION: We compared the satisfaction levels of patients with type 2 diabetes undergoing combination therapy with lixisenatide (LIX) and basal insulin with that of patients undergoing multiple daily insulin injection (MDI) therapy. MATERIALS AND METHODS: The study was a 12-week open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes receiving MDI for more than 3 months. Patients were randomly assigned to each treatment cohort: (1) a group that continued MDI (MDI group); and (2) a group that switched from MDI to combination therapy with LIX and basal insulin (LIX group)...
March 10, 2017: Journal of Diabetes Investigation
Su Jeong Song, Kyungdo Han, Kyung Seek Choi, Seung-Hyun Ko, Eun-Jung Rhee, Cheol-Young Park, Joong-Yeol Park, Kyung-Soo Ko, Ki-Up Lee
AIMS/INTRODUCTION: This study aimed to analyze the temporal changes in the prevalence, screening rate, visual impairments, and treatment patterns of diabetic retinopathy in the Korean population over 8 years. MATERIALS AND METHODS: This was a retrospective population-based study of Korean national health insurance beneficiaries aged 30 years or older with type 2 diabetes, obtained from the Korean National Health Insurance Claims database from 2006 to 2013 (n = 1,655,495 in 2006 and 2,720,777 in 2013)...
March 10, 2017: Journal of Diabetes Investigation
Nobuyuki Takahashi, Tetsuro Tsujimoto, Daisuke Chujo, Hiroshi Kajio
AIMS/INTRODUCTION: To compare the incidence rate of renal dysfunction between patients with fulminant type 1 diabetes (FT1D) and those with acute-onset type 1 diabetes (AT1D). MATERIALS AND METHODS: This retrospective cohort study included patients with FT1D and AT1D diagnosed during April 1993-March 2016 at a national center in Japan. Glycated hemoglobin levels, incidence rates of renal dysfunction defined as an estimated glomerular filtration rate of <60 ml/min/1...
March 7, 2017: Journal of Diabetes Investigation
Kyoichiro Tsuchiya, Yoshihiro Ogawa
Forkhead box class O family member proteins (FoxOs) of transcription factors are essential regulators of cellular homeostasis, including glucose and lipid metabolism, oxidative stress response and redox signaling, cell cycle progression and apoptosis. Altered FoxO1 expression and activity have been associated with glucose intolerance, dyslipidemia, and complications of diabetes. In liver, they direct carbons to glucose or lipid utilization, thus providing a unifying mechanism for the two abnormalities of the diabetic liver: excessive glucose production, and increased lipid synthesis and secretion...
March 7, 2017: Journal of Diabetes Investigation
Chien-Ju Yang, Hsiu-Yun Hsu, Chieh-Hsiang Lu, Yen-Li Chao, Haw-Yen Chiu, Li-Chieh Kuo
AIMS/INTRODUCTION: The purpose of this study is to identify whether there are differences in hand dexterity, hand functional performance and quality of life between diabetes hands with mononeuropathy and polyneuropathy to further present the importance regarding impacts of diabetic neuropathic deficits on patient's functional capacity. MATERIALS AND METHODS: The neurological deficits of 127 patients with type 2 diabetes were examined by electrophysiological tests for the median and ulnar nerves and were stratified into the diabetic mononeuropathy, diabetic polyneuropathy and non-diabetic neuropathy groups by sensory amplitude of these nerves...
March 7, 2017: Journal of Diabetes Investigation
Amro M Stino, A Gordon Smith
Peripheral neuropathy is a major cause of disability worldwide. Diabetes is the most common cause of neuropathy, accounting for 50% of cases. Over half of people with diabetes develop neuropathy, and diabetic neuropathy (DPN) is a major cause of reduced quality of life due to pain, sensory loss, gait instability, fall related injury, and foot ulceration and amputation. Most patients with nondiabetic neuropathy have cryptogenic sensory peripheral neuropathy (CSPN). A growing body of literature links prediabetes, obesity and metabolic syndrome (MetS) to risk of both DPN and CSPN (CSPN-MetS)...
March 7, 2017: Journal of Diabetes Investigation
Su-Yen Goh, Zanariah Hussein, Achmad Rudijanto
Although the incidence of diabetes is rising in South East Asia, there is limited information regarding the incidence and manifestation of insulin-associated hypoglycemia. The aim of this review is to discuss what is currently known regarding insulin-associated hypoglycemia in South East Asia, including its known incidence and impact in the region, and how the South East Asian population with diabetes differs from other populations. We found a paucity of data regarding the incidence of hypoglycemia in South East Asia that has contributed to the adoption of Western guidelines...
February 25, 2017: Journal of Diabetes Investigation
Yutaka Seino, Yasuo Terauchi, Xiangling Wang, Daisuke Watanabe, Elisabeth Niemoeller
AIM/INTRODUCTION: To assess overall safety of lixisenatide monotherapy in Japanese patients with type 2 diabetes mellitus. MATERIALS AND METHODS: Patients with type 2 diabetes mellitus, previously treated with ≤1 oral antidiabetic drugs, were enrolled in an uncontrolled, open-label, single-arm study over 24 and 52 weeks. Any oral antidiabetic drug treatment was stopped at the start of the 6-week run-in period. From baseline, patients received once-daily lixisenatide monotherapy (10 μg for 1 week, 15 μg for 1 week, 20 μg thereafter) for 52 weeks (first 140 patients enrolled) or 24 weeks (subsequently enrolled patients)...
February 13, 2017: Journal of Diabetes Investigation
Yasuo Ohashi, Michael Lyng Wolden, Jacob Hyllested-Winge, Meryl Brod
AIMS: This study investigated the impact of non-severe hypoglycaemic events (NSHE) on patients' diabetes management, daily functioning and well-being. METHODS: A survey assessing the impact of NSHEs was completed by insulin-treated Japanese people with diabetes, aged ≥20 years with self-reported diabetes, who had experienced at least one NSHE in the last 3 months. Survey questions captured reasons for and length of the event, and impacts on diabetes management, daily functioning, sleep and well-being...
February 8, 2017: Journal of Diabetes Investigation
Hiroyo Ninomiya, Naoto Katakami, Taka-Aki Matsuoka, Mitsuyoshi Takahara, Hitoshi Nishizawa, Norikazu Maeda, Michio Ohtsuki, Akihisa Imagawa, Hiroyasu Iso, Tetsuya Ohira, Iichiro Shimomura
AIMS/INTRODUCTION: It is suggested that positive psychosocial condition has a good effect on health and glycemic control. However, there has been no research to evaluate the association between positive psychosocial factors and diabetic nephropathy (DN). The aim of this study was to evaluate the association between psychosocial factors and DN in patients with type 2 diabetes. MATERIAL AND METHODS: To assess psychosocial condition, 6 indicators (Happiness score, LOT-R score as an indicator of dispositional optimism, Laughter frequency, Self-awareness of stress, Social network, and Social support) were assessed by self-administered questionnaire, and associations between these psychosocial indicators and the presence of DN were examined...
February 8, 2017: Journal of Diabetes Investigation
Shiro Fukuda, Ayumu Hirata, Hitoshi Nishizawa, Hirofumi Nagao, Takekazu Kimura, Yuya Fujishima, Masaya Yamaoka, Junji Kozawa, Akihisa Imagawa, Tohru Funahashi, Norikazu Maeda, Iichiro Shimomura
Sleep pattern has been shown to associate with type 2 diabetes mellitus (T2DM). Here, we investigated the difference in bedtime, waking time, and estimated sleep duration in T2DM patients with or without visceral fat accumulation, using questionnaire on sleep patterns. The study subjects were 59 Japanese T2DM patients (males/females = 34/25, age 64.5 ± 12.1 years, mean ± SD). Visceral fat accumulation was defined as estimated visceral fat area ≥100cm(2) . The patients with visceral fat accumulation (N=40) showed significantly later bedtime (23:51 ± 1:27 in (+) group vs 22:49 ± 1:23 in (-) group) and shorter estimated sleep duration (6...
February 8, 2017: Journal of Diabetes Investigation
Atsunori Kashiwagi, Hiroshi Maegawa
The specific Na+/glucose co-transporter 2 inhibitors (SGLT2 inhibitors) inhibit glucose reabsorption in proximal renal tubular cells, and both fasting and postprandial glucose significantly decrease due to urinary glucose loss. As a result, pancreatic β-cell function and peripheral insulin action significantly improve with relief from glucose toxicity. Furthermore, whole body energy metabolism changes to relative glucose deficiency and triggers increased lipolysis in fat cells, and fatty acid oxidation and then ketone body production in the liver during treatment with SGLT2 inhibitors...
February 8, 2017: Journal of Diabetes Investigation
Jizhong Shen, Yun Fang, Huaijun Zhu, Weihong Ge
AIMS: The objective of this study was to investigate the relations between plasma interleukin-22 (IL-22) levels and prediabetes or Type 2 diabetes (T2DM) and search the relevance between plasma concentrations of IL-22 and selected diabetes risk factors in Chinese people. MATERIALS AND METHODS: The Han Chinese origin men and women subjects were recruited in our study during a conventional medical checkup. Fasting plasma IL-22 levels were detected by ELISA and their relevance with selected diabetes risk factors was explored...
February 7, 2017: Journal of Diabetes Investigation
Liu Gao, Lingling Bai, Min Shi, Jingxian Ni, Hongyan Lu, Yanan Wu, Jun Tu, Xianjia Ning, Jinghua Wang, Yukun Li
AIMS: Carotid intima-media thickness (CIMT) is an established predictor of cardiovascular disease and stroke. We aimed to identify the association between CIMT and blood glucose as well as the risk factors associated with increased CIMT in a low-income Chinese population. MATERIALS AND METHODS: Stroke-free and cardiovascular disease-free residents aged ≥45 years were recruited. B-mode ultrasonography was performed to measure CIMT. RESULTS: There were 2643 participants (71...
February 3, 2017: Journal of Diabetes Investigation
Eri Takahashi, Hiroyuki Unoki-Kubota, Yukiko Shimizu, Tadashi Okamura, Wakiko Iwata, Hiroshi Kajio, Ritsuko Yamamoto-Honda, Tomoko Shiga, Shigeo Yamashita, Kazuyuki Tobe, Akinori Okumura, Michihiro Matsumoto, Kazuki Yasuda, Mitsuhiko Noda, Yasushi Kaburagi
AIM: To identify candidate serum molecules associated with the progression of type 2 diabetes mellitus (T2DM), differential serum proteomic analysis was performed on a spontaneous animal model of T2DM without obesity, the Long-Evans Agouti (LEA) rat. MATERIALS AND METHODS: We performed quantitative proteomic analysis using serum samples from 8- and 16-week-old LEA and control Brown Norway (BN) rats (n=4/group). Differentially expressed proteins were validated by multiple reaction monitoring (MRM) analysis using the sera collected from 8-, 16- and 24-week-old LEA (n = 4/each group) and BN rats [n = 5/each group]...
February 2, 2017: Journal of Diabetes Investigation
Takeshi Kurose, Yoshiyuki Hamamoto, Yutaka Seino
Recent major progress in clinical management of type 2 diabetes mellitus has been accomplished with the introduction of several new classes of drugs, some of which may also improve cardiovascular outcomes. Most of these studies are supported by pharmaceutical companies and claim CV (cardiovascular) benefits. However whether or not these benefits hold in clinical settings is dubious. This article is protected by copyright. All rights reserved.
January 28, 2017: Journal of Diabetes Investigation
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