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Journal of Diabetes Investigation

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https://www.readbyqxmd.com/read/28731289/current-status-of-achieving-blood-pressure-target-and-its-clinical-correlates-in-japanese-type-2-diabetes
#1
Hiroki Yokoyama, Shin-Ichi Araki, Koichi Kawai, Koichi Hirao, Yoshio Kurihara, Hiroaki Seino, Hiroshi Takamura, Hidekatsu Sugimoto, Akira Okada, Hiroshi Maegawa
AIMS/INTRODUCTION: To investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drug classes as of 2013, and to explore the clinical correlates with achievement of target blood pressure in a large-scale cohort of Japanese subjects with type 2 diabetes. MATERIALS AND METHODS: A nationwide survey was conducted including 12,811 subjects with type 2 diabetes. Subjects were divided by achieved blood pressure, <130/80 or 140/90 mmHg, and the number of drug classes taken...
July 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28686352/the-ratio-of-visceral-to-subcutaneous-fat-area-predicts-cardiovascular-events-in-patients-with-type-2-diabetes
#2
Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
AIMS/INTRODUCTION: To investigate whether the ratio of visceral fat area (VFA) to subcutaneous fat area (SFA) (V/S ratio) could be predictive of cardiovascular disease (CVD) as compared with VFA or SFA in patients with diabetes. MATERIALS AND METHODS: 682 patients with type 2 diabetes (mean age 64 ± 13 years; 41% female) were enrolled. VFA (cm(2) ) and SFA (cm(2) ) were assessed by dual bioelectrical impedance analyzer (BIA). The patients were divided into four groups according to the quartiles of V/S ratio...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28686322/characteristics-of-frequent-emergency-department-users-with-type-2-diabetes-mellitus-in-korea
#3
Morena Ustulin, Junghoon Woo, Jeong-Taek Woo, Sang Youl Rhee
AIMS/INTRODUCTION: Frequent emergency department (ED) visitors are medically vulnerable subjects. We identified the characteristics of "frequent ED users" among Korean patients with type 2 diabetes mellitus (DM). MATERIALS AND METHODS: We used the Health Insurance Review and Assessment Service National Patient Sample HIRA-(NPS), which is a nationally representative sample. Subjects (n = 109,412) with type 2 DM as a primary or secondary diagnosis at one of their visits were included...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28685995/meta-analysis-and-critical-review-on-the-efficacy-and-safety-of-alpha-glucosidase-inhibitors-in-asian-and-non-asian-populations
#4
Xueying Gao, Xiaoling Cai, Wenjia Yang, Yifei Chen, Xueyao Han, Linong Ji
AIMS: To evaluate the efficacy and safety of alpha glucosidase inhibitors (AGI) in Asian and non-Asian type 2 diabetic patients. MATERIALS AND METHODS: Studies were identified through a literature search of MEDLINE, EMBASE, and other databases until December 2016. All statistical analyses were conducted in Review Manager statistical software by computing the weighted mean difference (WMD) or odds ratio (OR) and 95% confidence interval (CI). RESULTS: A total of 67 studies were included...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28685957/the-characteristics-of-carotid-atherosclerosis-in-elderly-patients-with-type-2-diabetes-at-different-disease-course-and-the-intervention-by-statins-in-the-very-elderly-patients
#5
Wenjun Chen, Tao Tian, Shiming Wang, Yan Xue, Zongqin Sun, Shuli Wang
INTRODUCTION: Chronic complications of diabetes have become the leading cause of death in elderly patients with diabetes. Carotid atherosclerosis, one of the major complications was evaluated and the effect of atorvastatin on carotid atherosclerosis in very elderly patients with type 2 diabetes (T2D) were observed. MATERIAL AND METHODS: Patients were divided into 3 groups: 1) disease course < 5 years; 2) disease course = 5-10 years; 3) disease course > 10 years, and carotid atherosclerosis were evaluated...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28667795/dietary-intake-habits-and-prevalence-of-nocturia-in-japanese-patients-with-type-2-diabetes-mellitus
#6
Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Hisaka Minami, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake
AIMS/INTRODUCTION: No reports have been published on the association between dietary intake habits and nocturia in the diabetes population. We therefore estimate this issue among Japanese patients with diabetes mellitus. MATERIALS AND METHODS: Study subjects in the present study were 785 Japanese patients with type 2 diabetes mellitus. Self-administrated questionnaires were used to assess each type of dietary intake habits. Vegetable intake habit was assessed by the following question: Do you have vegetables or seaweed every day?" We used the following two outcomes: 1) nocturia: ≥ 2 voids per night and 2) severe nocturia: ≥ 3 voids per night...
July 1, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28664593/clinical-surrogate-markers-for-predicting-metabolic-syndrome-in-middle-aged-and-elderly-chinese
#7
Rui Li, Qi Li, Min Cui, Zegang Yin, Ling Li, Tingting Zhong, Yingchao Huo, Peng Xie
AIMS/INTRODUCTION: This study evaluated the ability of lipid accumulation product (LAP), visceral adiposity index (VAI) and the product of triglycerides and glucose (TyG), three novel markers, in identifying metabolic syndrome (MetS) with different criteria in middle-aged and elderly Chinese. MATERIALS AND METHODS: During June 2012-January 2013, 992 consecutive patients (age≥40 years) were enrolled in Daping Hospital. The criteria of MetS were based on the International Diabetes Federation (IDF) and the modified National Cholesterol Education Program's Adult Treatment Panel III (ATPIII)...
June 30, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28646618/tryptophan-as-a-surrogate-prognostic-marker-for-diabetic-nephropathy
#8
Chien-An Chou, Chia-Ni Lin, Daniel Tsun-Yee Chiu, I-Wen Chen, Szu-Tah Chen
AIMS/INTRODUCTION: Diabetic nephropathy is one of the leading causes of end-stage renal disease. Unfortunately, reliable surrogate markers for predicting the prognostic outcome of diabetic nephropathy were as yet absent. In order to find new markers in predicting the progression of diabetic nephropathy, we conducted a prospective study by investigating the correlation between serum metabolites and the annual change of estimated glomerular filtration rate (eGFR). MATERIALS AND METHODS: From September 2013 to September 2015, 52 diabetic patients at various stages of chronic kidney disease (CKD) were enrolled...
June 24, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28644562/efficacy-of-ipragliflozin-as-monotherapy-or-as-add-on-therapy-with-other-oral-antidiabetic-medications-in-treating-type-2-diabetes-in-japanese-patients-with-inadequate-glycemic-control-a-subgroup-analysis-based-on-patient-characteristics
#9
Takeshi Osonoi, Shinya Nakamoto, Miyoko Saito, Atsuko Tamasawa, Hidenori Ishida, Yusuke Osonoi
AIMS/INTRODUCTION: The aim of the present study was to evaluate the efficacy and safety of ipragliflozin in treating Japanese type 2 diabetic patients with inadequate glycemic control by investigating diurnal variations of blood glucose and body composition. MATERIALS AND METHODS: This was an investigator-initiated, multicenter, prospective study with a 6-month treatment period. The primary outcome investigated was change in hemoglobin A1c levels from baseline. Secondary outcomes included changes in fasting plasma glucose, insulin resistance, variations in 24-h glucose levels detected by continuous glucose monitoring, body weight, body composition, waist circumference, and serum lipids...
June 23, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28626953/translation-and-validation-of-the-insulin-treatment-appraisal-scale-in-hong-kong-primary-care-patients
#10
K P Lee
AIM: Patients with type 2 diabetes mellitus (DM) often delay the initiation or titration of insulin treatment due to psychological factors. This phenomenon is referred to as psychological insulin resistance (PIR). The insulin treatment appraisal scale (ITAS) is a 20-item instrument for assessing PIR. A previous Chinese version of the ITAS (C-ITAS) was found to be subject to problems arising from its translation. The present study aimed to translate and validate this instrument, which will facilitate research and aid in counselling in a clinical setting...
June 19, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28613394/regular-exercise-behavior-is-related-to-lower-extremity-muscle-strength-in-patients-with-type-2-diabetes-data-from-the-muscle-std-study
#11
Takuo Nomura, Tomoyasu Ishiguro, Masayoshi Ohira, Yukio Ikeda
Owing to several contributing factors, continuation of exercise therapy is difficult in patients with type 2 diabetes. One potential factor that has not been well examined is the influence of muscle strength on regular exercise behavior. We examined the relationship between regular exercise behavior and knee extension force (KEF) in 1,442 patients with type 2 diabetes. In sex-specific univariate analysis, KEF was significantly higher in patients with regular exercise than in patients without regular exercise...
June 14, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28609558/ipsc-technology-based-regenerative-therapy-for-diabetes
#12
REVIEW
Yasushi Kondo, Taro Toyoda, Nobuya Inagaki, Kenji Osafune
The directed differentiation of human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), into pancreatic endocrine lineages has been vigorously examined by reproducing the in vivo developmental processes of pancreas. Recent advances in this research field have enabled the generation from hESCs/iPSCs of functionally mature β-like cells in vitro that show glucose-responsive insulin secretion ability. The therapeutic potentials of hESC/iPSC-derived pancreatic cells have been evaluated using diabetic animal models, and transplantation methods including immunoprotective devices that prevent immune responses from hosts to the implanted pancreatic cells have been investigated towards the development of regenerative therapies against diabetes...
June 13, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28597607/immaturity-of-insulin-secretion-by-pancreatic-islets-isolated-from-one-human-neonate
#13
Jean-Claude Henquin, Myriam Nenquin
Human β-cells are functionally mature by the age of one year. The timing and mechanisms of this maturation are unknown owing to the exceptional availability of testable tissue. Here, we report the first in vitro study of insulin secretion by islets from a 5 day-old newborn. Glucose alone was inefficient but glucose-stimulation became concentration-dependent, displayed a biphasic time-course and was of similar magnitude as in infant islets when β-cell cAMP was raised by forskolin. Tolbutamide alone was effective in low glucose, but its effect was not augmented by high glucose...
June 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28593750/impact-of-obesity-on-mortality-in-patients-with-diabetes-meta-analysis-of-20-studies-including-250-016-patients
#14
Fei Gao, Zhi Jian Wang, Hua Shen, Shi Wei Yang, Bin Nie, Yu Jie Zhou
AIMS/INTRODUCTION: The impact of body mass index on mortality among patients with diabetes remains controversial. Therefore, we carried out a meta-analysis of pertinent studies. MATERIALS AND METHODS: We searched OVID/MEDLINE, EMBASE and Cochrane databases for all reported studies, which investigated the relationship between body mass index and mortality in patients with diabetes. Summary estimates of hazard ratios (HRs) were obtained with a random effects model...
June 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28563974/performance-of-a-new-real-time-continuous-glucose-monitoring-system-a-multicenter-pilot-study
#15
Jian Zhou, Shuo Zhang, Liang Li, Yufei Wang, Wei Lu, Chunjun Sheng, Yiming Li, Yuqian Bao, Weiping Jia
BCAKGROUND: This study was to investigate the performance of a new real-time continuous glucose monitoring (RT-CGM) system. METHODS: Interstitial glucose levels were monitored for 7 days in 63 patients with type 1 or type 2 diabetes using the Medtrum A6 TouchCare(®) CGM System. Venous blood was collected on a randomized day of the wear period. Plasma glucose levels were measured as reference values. RESULTS: Among 1,678 paired sensor-reference values, 90...
May 31, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28556616/fast-acting-insulin-aspart-in-japanese-patients-with-type-1-diabetes-faster-onset-higher-early-exposure-and-greater-early-glucose-lowering-effect-relative-to-insulin-aspart
#16
Masanari Shiramoto, Tomoyuki Nishida, Ann Kathrine Hansen, Hanne Haahr
AIMS/INTRODUCTION: Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with two added excipients (niacinamide and L-arginine) in order to obtain accelerated absorption after subcutaneous dosing. This study compared the pharmacokinetic/pharmacodynamic characteristics of faster aspart vs. IAsp in Japanese patients with type 1 diabetes (T1D). MATERIALS AND METHODS: In a randomized, double-blind, crossover design, 43 participants were administered faster aspart and IAsp (0...
May 27, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28556518/low-hba1c-level-is-associated-with-severity-of-frailty-in-japanese-elderly-diabetic-patients
#17
Ikumi Yanagita, Yuya Fujihara, Terumi Eda, Misuzu Tajima, Kazue Yonemura, Tomoko Kawajiri, Noriko Yamaguchi, Hideko Asakawa, Yukiko Nei, Yumi Kayashima, Mihoko Yoshimoto, Yuichi Kitajima, Mayumi Harada, Yuhei Araki, Syoji Yoshimoto, Eiji Aida, Toshihiko Yanase, Hajime Nawata, Kazuo Muta
AIMS/INTRODUCTION: Previously, a study using a narrowly defined (physical base) frailty scale reported that both good and bad (U-shaped curve) HbA1c levels were frailty risk factors in patients with type 2 diabetes mellitus (T2DM). However, no such studies have demonstrated this in Japan. We aimed to evaluate the frailty risk factors including HbA1c in elderly Japanese patients with T2DM using a broadly defined (both physical and psychosocial base) frailty scale, the Clinical Frailty Scale (CFS)...
May 27, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28520234/bullous-pemphigoid-associated-with-dipeptidyl-peptidase-4-inhibitors-a-report-of-five-cases
#18
Satoshi Yoshiji, Takaaki Murakami, Shin-Ichi Harashima, Rie Ko, Riko Kashima, Daisuke Yabe, Masahito Ogura, Kentaro Doi, Nobuya Inagaki
Bullous pemphigoid (BP) is an autoimmune blistering skin disorder. Recently, BP induced by dipeptidyl peptidase-4 (DPP-4) inhibitors has been a concern. Although DPP-4 inhibitors are commonly used in the Asian population due to their safety and efficacy, BP associated with DPP-4 inhibitors is sometimes seen in clinical settings. Here we report five Japanese cases of BP associated with the agents. In our cases, BP occurred in the elderly by 4 different DPP-4 inhibitors, which showed various clinical manifestations in terms of latency period for BP, sex, glycemic control, and diabetes duration...
May 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28519964/association-between-serum-25-hydroxyvitamin-d-and-glycated-hemoglobin-levels-in-type-2-diabetes-patients-with-chronic-kidney-disease
#19
Lee Ling Lim, Yong Muh Ng, Pei San Kang, Soo Kun Lim
AIMS/INTRODUCTION: Vitamin D is suggested to influence glucose homeostasis. An inverse relationship between serum 25-hydroxyvitamin D [25(OH)D] and glycemic control in non-chronic kidney disease (CKD) patients with type 2 diabetes (T2D) was reported. We aimed to examine this association among T2D patients with CKD. MATERIALS AND METHODS: 100 T2D participants with stage 3-4 CKD were recruited. Blood for HbA1c , serum 25(OH)D, renal, and lipid profiles were drawn at enrolment...
May 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28502112/sglt2-inhibitor-luseogliflozin-added-to-glucagon-like-peptide-1-receptor-agonist-liraglutide-improves-glycemic-control-with-bodyweight-and-fat-mass-reductions-in-japanese-patients-with-type-2-diabetes-a-52-week-open-label-single-arm-study
#20
Yutaka Seino, Daisuke Yabe, Takashi Sasaki, Atsushi Fukatsu, Hisae Imazeki, Hidekazu Ochiai, Soichi Sakai
AIMS/INTRODUCTION: To evaluate the safety and efficacy of luseogliflozin added to liraglutide monotherapy in Japanese individuals with type 2 diabetes (T2D). MATERIALS AND METHODS: This 52-week, multicenter, open-label, single-arm clinical study enrolled Japanese patients who had inadequate glycemic control with diet/exercise and liraglutide monotherapy. Major efficacy endpoints included the changes from baseline in HbA1c, fasting plasma glucose (FPG), and bodyweight...
May 14, 2017: Journal of Diabetes Investigation
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