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Journal of Diabetes Investigation

Isao Muraki, Hiroo Wada, Takeshi Tanigawa
The aim of this review is to clarify the association between obstructive sleep apnea (OSA) and type 2 diabetes, and discuss the therapeutic role of continuous positive airway pressure (CPAP) in type 2 diabetes. OSA patients are more likely than non-OSA populations to develop type 2 diabetes while more than half of patients with type 2 diabetes suffer from OSA. Similarly to the Western countries, in the East Asian population, the association between these two disorders has also been reported. CPAP is the primary treatment for OSA, but the effect of CPAP on comorbid diabetes has not been established...
February 17, 2018: Journal of Diabetes Investigation
Kaori Ikeda, Shimpei Fujimoto, Beth Morling, Shiho Ayano-Takahara, Shin-Ichi Harashima, Yukiko Uchida, Nobuya Inagaki
The aim of this study is to evaluate how culture moderates the behavioral and psychosocial predictors of diabetes self-care activities. Patients with type 2 diabetes were recruited in the outpatient department at two sites: Kyoto University hospital in Japan and the Christiana Care Health System in the United States. The data was collected by survey using questionnaires including questions on the frequency of self-care activities, behavioral and psychosocial predictors, and other background information from 149 Japanese patients and 48 American patients...
February 17, 2018: Journal of Diabetes Investigation
Akinobu Nakamura, Hideaki Miyoshi, Shigekazu Ukawa, Koshi Nakamura, Takafumi Nakagawa, Yasuo Terauchi, Akiko Tamakoshi, Tatsuya Atsumi
We investigated the association between serum high molecular weight (HMW) adiponectin and insulin secretion in a population-based study, with or without adjustment for insulin sensitivity. A total of 488 participants (263 women) were included in the present study. Insulin secretion was estimated using the homeostasis model assessment of beta-cell function (HOMA-β%) ± adjustment for insulin resistance (IR) using the disposition index (DI). Multivariate analysis revealed that HMW adiponectin was significantly and inversely associated with HOMA-β% (partial regression coefficient: -0...
February 16, 2018: Journal of Diabetes Investigation
Qing Zhou, Qian Ge, Yao Ding, Hua Qu, Huili Wei, Rui Wu, Lu Yao, Qianping Wei, Zhengping Feng, Jian Long, Huacong Deng
AIMS: To detect serum adipsin levels in subjects with different glucose tolerance and investigate the relationship between adipsin and first-phase of insulin secretion. METHODS: 56 patients with newly diagnosed type 2 diabetes mellitus(T2DM), 36 patients with impaired glucose tolerance (IGT), and 45 subjects with normal glucose tolerance (NGT) were enrolled. Intravenous glucose tolerance tests were performed to evaluate pancreatic β cell function. The serum levels of adipsin, interleukin 1β (IL-1β), hypersensitive C Reactive Protein (hs-CRP) were assayed...
February 12, 2018: Journal of Diabetes Investigation
Kazuhiro Hirayasu, Hideyuki Sasaki, Shohei Kishimoto, Seigo Kurisu, Koji Noda, Kenichi Ogawa, Hiroto Tanaka, Yumiko Sakakibara, Shohei Matsuno, Hiroto Furuta, Mikio Arita, Keigo Naka, Kishio Nanjo
AIM/INTRODUCTION: Studies on a novel point-of-care device for nerve conduction study called DPNCheck have been limited to Westerners. We aimed to clarify Japanese normal limits of nerve action potential (Amp) and conduction velocity (CV) by DPNCheck (Investigation-I), and validity of DPNCheck to identify diabetic symmetric sensorimotor polyneuropathy (DSPN) (Investigation-II). MATERIALS AND METHODS: Investigation-I: 463 non-neuropathic Japanese subjects underwent DPNCheck examinations...
February 11, 2018: Journal of Diabetes Investigation
Taiga Shibayama, Noguchi Haruko, Hideto Takahashi, Nanako Tamiya
AIMS/INTRODUCTION: Social engagement may positively eaffect health status, but its effect on diabetes incidence remains unclear. This study aimed to assess the relationship between social engagement and diabetes incidence in a middle-aged Japanese population. MATERIALS AND METHODS: We analyzed data on 31,615 people aged 50-59 years from a prospective national survey conducted in Japan from 2005 to 2013. Diabetes incidence was measured by asking respondents annually whether they had been diagnosed with diabetes by a physician in the previous year...
February 11, 2018: Journal of Diabetes Investigation
Hiroto Sasamori, Tomoyasu Fukui, Toshiyuki Hayashi, Takeshi Yamamoto, Makoto Ohara, Saki Yamamoto, Tetsuro Kobayashi, Tsutomu Hirano
BACKGROUND: A decrease in the size of the pancreas is observed in islet autoantibody-positive non-diabetic donors and acute-onset type 1 diabetes (AT1D) irrespective of the diabetes duration. Little is known, however, about the relationship between the size of the pancreas and T1D subtypes, including fulminant T1D (FT1D). METHODS: We examined the pancreatic volume (PV) in 44 adult patients with T1D (16 AT1D, 18 slowly progressive [SPT1D], and 10 FT1D) and 39 age- and BMI- matched non-diabetic controls...
February 10, 2018: Journal of Diabetes Investigation
Kairong Zheng, Ning Wang, Yinchen Shen, Zhihua Zhang, Qing Gu, Xu Xu, Qing Qin, Yinchen Liu
OBJECTIVE: This study aims to explore the effects of microRNA-365 (miR-365) on apoptosis of retinal neurons by targeting IGF-1 in diabetes mellitus (DM) rats. METHODS: High glucose-induced retinal neurons were assigned into the blank (with no plasmid transfection), negative control (NC, with plasmid transfection), anti-miR-365(transfected miR-365 antagomir), sh-IGF-1 (transfected IGF-1 shRNA plasmid), and anti-miR-365 + sh-IGF-1 (transfected miR-365 antagomir and IGF-1 shRNA plasmid) groups...
February 10, 2018: Journal of Diabetes Investigation
Hiroshi Sakura, Naotake Hashimoto, Kazuo Sasamoto, Hiroshi Ohashi, Sumiko Hasumi, Noriko Ujihara, Tadasu Kasahara, Osamu Tomonaga, Hideo Nunome, Masashi Honda, Yasuhiko Iwamoto
AIMS/INTRODUCTION: Hemoglobin A1c (HbA1c) levels in patients with type 2 diabetes mellitus (T2DM) fluctuate throughout the year. However, there are few studies that have evaluated the therapeutic effect of hypoglycemic agents while considering such fluctuations. In a multi-center study (JAMP Study), pre-treatment patients with T2DM were divided into seven groups and administered sitagliptin for 1 year. The aim of this study was to evaluate the differences in the therapeutic effect, and efficacy, of sitagliptin in patients with T2DM based on the month administration of the drug began as sub-analysis of the JAMP Study...
February 10, 2018: Journal of Diabetes Investigation
Lawrence J Coppey, Hanna Shevalye, Alexander Obrosov, Eric P Davidson
AIMS/INTRODUCTION: Peripheral neuropathy is a common complication of diabetes and also occurs in 30% of human obese subjects with impaired glucose tolerance. Even though peripheral neuropathy affects both genders most pre-clinical studies have been performed using male rodents. The aim of this study was to create diet induced obesity and type 2 diabetes in female rats and mice in order to examine development of peripheral neuropathy. MATERIALS AND METHODS: At twelve weeks of age rats and mice were separated into three groups...
February 7, 2018: Journal of Diabetes Investigation
Hidenori Hirukawa, Mitsuru Hashiramoto, Yukio Tanizawa, Kohei Kaku
AIMS: To assess whether intervention with oral anti-diabetic drug in Japanese patients with the early stage of type 2 diabetes could provide a significant remission of the disease process. METHODS: Patients with diabetes duration less than 5 years were randomized to the lifestyle modification (LFS), pioglitazone (PIO), or sulfonylurea (SU) treatment group. In phase 1 as on-treatment period and in phase 2 as off-treatment period, the duration kept HbA1c less than the target was compared among groups...
February 6, 2018: Journal of Diabetes Investigation
Yukio Horikawa
Maturity-onset diabetes of the young (MODY) is a form of diabetes classically characterized as having autosomal dominant inheritance, onset before the age of 25 years in at least one family member and partly preserved pancreatic β cell function. The fourteen responsible genes are reported to be MODY1~14, of which MODY2 and 3 may be the most common forms. Although MODY is currently classified as diabetes of a single gene defect, it has become clear that mutations in rare MODYs, such as MODY5 and MODY6, have small mutagenic effects and low penetrance...
February 6, 2018: Journal of Diabetes Investigation
Huanhuan Hu, Tohru Nakagawa, Shuichiro Yamamoto, Toru Honda, Hiroko Okazaki, Akihiko Uehara, Makoto Yamamoto, Toshiaki Miyamoto, Takeshi Kochi, Masafumi Eguchi, Taizo Murakami, Makiko Shimizu, Kentaro Tomita, Satsue Nagahama, Teppei Imai, Akiko Nishihara, Naoko Sasaki, Takayuki Ogasawara, Ai Hori, Akiko Nanri, Shamima Akter, Keisuke Kuwahara, Ikuko Kashino, Isamu Kabe, Tetsuya Mizoue, Tomofumi Sone, Seitaro Dohi
AIMS/INTRODUCTION: We previously developed a 3-year diabetes risk score in the working population. The objective of the present study was to develop and validate flexible risk models that can predict the risk of diabetes for any arbitrary time point during 7 years. MATERIALS AND METHODS: The participants were 46,198 Japanese employees aged 30-59 years, without diabetes at baseline and with a maximum follow-up of 8 years. Incident diabetes was defined according to the American Diabetes Association criteria...
January 30, 2018: Journal of Diabetes Investigation
Adnan Khan, Ioannis N Petropoulos, Georgios Ponirakis, Robert A Menzies, Omar Chidiac, Jennifer Pasquier, Charbel A Khalil, Talal K Talal, Rayaz A Malik
AIMS/INTRODUCTION: The aim of this study was to identify the extent of small fibre neuropathy in patients with Charcot neuroarthropathy (CN). MATERIALS AND METHODS: 20 patients with CN were compared to 20 age and diabetes duration-matched patients with Type 2 diabetes and 20 age-matched controls. All patients underwent CCM with quantification of corneal nerve morphology and assessment for vibration perception threshold and a subset of patients with CN underwent assessment of sudomotor function and neuropathic pain...
January 30, 2018: Journal of Diabetes Investigation
Pennie J Taylor, Campbell H Thompson, Grant D Brinkworth
This narrative review discusses the role of Continuous Glucose Monitoring (CGM) in glycaemic and weight control and lifestyle behaviour adherence in adults with type 2 diabetes (T2D). A literature search from January 2001 to November 2017 was conducted (MEDLINE, CINAHL, Web of Science and Scopus). Eligible studies were trials evaluating the use of CGM with the aim of achieving glucose control or lifestyle-related treatment adherence over a period of ≥8 weeks in adults with T2D compared to usual care or another comparison intervention OR observational trials reporting CGM user experience...
January 30, 2018: Journal of Diabetes Investigation
Hiroyuki Umegaki
Type 2 diabetes mellitus has been an established risk factor for cognitive decline, which is recently recognized as a new type of diabetes-related complication. Although wide-range of cognitive domains are impaired in type 2 diabetes mellitus subjects, executive function and processing speed are the most frequently reported to be impaired in older type 2 diabetes mellitus subjects. The mechanisms by which type 2 diabetes mellitus affects cognitive function, however, largely remain to be elucidated. This article is protected by copyright...
January 29, 2018: Journal of Diabetes Investigation
Yi-Cheng Chang, Siow-Wey Hee, Wei-Jei Lee, Hung-Yuan Li, Tien-Jyun Chang, Ming-Wei Lin, Yi-Jen Hung, I-Te Lee, Kuan-Yi Hung, Themistocles Assimes, Joshua W Knowles, Jiun-Yi Nong, Po-Chu Lee, Yen-Feng Chiu, Lee-Ming Chuang
AIM: Vascular adhesion protein-1 (VAP-1) is a membrane-bound amine oxidase highly expressed in mature adipocytes and is released into circulating. VAP-1 has been strongly implicated in several pathological process including diabetes, inflammation, hypertension, hepatic steatosis, and renal diseases and is an important disease marker and therapeutic target. Here we aimed to identify the genetic loci for circulating VAP-1 levels. METHODS: We conducted a genomic-wide linkage scan for the quantitative trait locus (QTL) of circulating VAP-1 levels in 1,100 Han Chinese subjects from 398 families in the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance (SAPPHIRe) study...
January 24, 2018: Journal of Diabetes Investigation
Jiangyuan Qin, Jinli Tian, Guanhua Liu, Yazhong Zhang, Luobing Tian, Yanfeng Zhen, Hewei Zhang, Jing Xu, Xueling Sun, Hui Fang
AIMS/INTRODUCTION: Variants on chromosome 1p13 have been associated with coronary artery disease and acute myocardial infarction risk in different ethnics. This study was aimed to investigate the association between 1p13 polymorphisms and the development of peripheral artery disease (PAD) in a Chinese population with type 2 diabetic mellitus (T2DM). MATERIALS AND METHODS: 1p13 polymorphisms rs599839, rs646776 and rs12740374 were assessed in a cohort of 882 T2DM cases including 440 T2DM with PAD (DM+PAD group) and 442 cases without PAD (DM group)...
January 22, 2018: Journal of Diabetes Investigation
Susumu Takagi, Jinpeng Li, Yuta Takagaki, Munehiro Kitada, Kyoko Nitta, Toshiyuki Takasu, Keizo Kanasaki, Daisuke Koya
OBJECTIVE: Complete mechanisms of reno-protective effects of SGLT2 inhibitors have not been elucidated yet. Mitochondrial biogenesis is regulated by membrane GTPases, such as Opa1 and Mfn2. Here, we investigated whether SGLT2 inhibition in mice fed with a high-fat diet (HFD) improved mitochondrial morphology and restored mitochondrial biogenesis-related molecules. MATERIALS AND METHODS: Mice were fed in control diet or HFD with or without ipragliflozin treatment...
January 20, 2018: Journal of Diabetes Investigation
Xiaojing Wang, Wei Li, Liangkun Ma, Fan Ping, Juntao Liu, Xueyan Wu, Jiangfeng Mao, Xi Wang, Min Nie
AIMS/INTRODUCTION: Emerging evidence suggested that the genetic background of GDM was analogous to T2DM. In contrast to T2DM, the genetic studies for GDM were limited. Accordingly, the aim of this study was to extensively explore the influence of miR-binding-SNPs in T2DM candidate loci on GDM susceptibility in Chinese. METERIALS AND METHODS: A total of 839 GDM and 900 controls were enrolled. Six miR-binding-SNPs were selected from 30 T2DM susceptibility loci and genotyped using TaqMan allelic discrimination assays...
January 20, 2018: Journal of Diabetes Investigation
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