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Journal of Diabetes Investigation

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https://www.readbyqxmd.com/read/28520234/bullous-pemphigoid-associated-with-dipeptidyl-peptidase-4-inhibitors-a-report-of-five-cases
#1
Satoshi Yoshiji, Takaaki Murakami, Shin-Ichi Harashima, Rie Ko, Riko Kashima, Daisuke Yabe, Masahito Ogura, Kentaro Doi, Nobuya Inagaki
Bullous pemphigoid (BP) is an autoimmune blistering skin disorder. Recently, BP induced by dipeptidyl peptidase-4 (DPP-4) inhibitors has been a concern. Although DPP-4 inhibitors are commonly used in the Asian population due to their safety and efficacy, BP associated with DPP-4 inhibitors is sometimes seen in clinical settings. Here we report five Japanese cases of BP associated with the agents. In our cases, BP occurred in the elderly by 4 different DPP-4 inhibitors, which showed various clinical manifestations in terms of latency period for BP, sex, glycemic control, and diabetes duration...
May 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28519964/association-between-serum-25-hydroxyvitamin-d-and-glycated-hemoglobin-levels-in-type-2-diabetes-patients-with-chronic-kidney-disease
#2
Lee Ling Lim, Yong Muh Ng, Pei San Kang, Soo Kun Lim
AIMS/INTRODUCTION: Vitamin D is suggested to influence glucose homeostasis. An inverse relationship between serum 25-hydroxyvitamin D [25(OH)D] and glycemic control in non-chronic kidney disease (CKD) patients with type 2 diabetes (T2D) was reported. We aimed to examine this association among T2D patients with CKD. MATERIALS AND METHODS: 100 T2D participants with stage 3-4 CKD were recruited. Blood for HbA1c , serum 25(OH)D, renal, and lipid profiles were drawn at enrolment...
May 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28502112/sglt2-inhibitor-luseogliflozin-added-to-glucagon-like-peptide-1-receptor-agonist-liraglutide-improves-glycemic-control-with-bodyweight-and-fat-mass-reductions-in-japanese-patients-with-type-2-diabetes-a-52-week-open-label-single-arm-study
#3
Yutaka Seino, Daisuke Yabe, Takashi Sasaki, Atsushi Fukatsu, Hisae Imazeki, Hidekazu Ochiai, Soichi Sakai
AIMS/INTRODUCTION: To evaluate the safety and efficacy of luseogliflozin added to liraglutide monotherapy in Japanese individuals with type 2 diabetes (T2D). MATERIALS AND METHODS: This 52-week, multicenter, open-label, single-arm clinical study enrolled Japanese patients who had inadequate glycemic control with diet/exercise and liraglutide monotherapy. Major efficacy endpoints included the changes from baseline in HbA1c, fasting plasma glucose (FPG), and bodyweight...
May 14, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28494143/the-normal-meal-tolerance-test-is-preferable-to-the-glucagon-stimulation-test-in-patients-with-type-2-diabetes-that-are-not-in-a-hyperglycemic-state-comparison-with-the-change-of-%C3%AE-cpr
#4
Youhei Fujioka, Tsuyoshi Ohkura, Keisuke Sumi, Kazuhisa Matsumoto, Kyoko Shoji, Risa Nakamura, Kazuhiko Matsuzawa, Shoichiro Izawa, Masahiko Kato, Shinichi Taniguchi, Kazuhiro Yamamoto
AIMS: The aim of this study was to evaluate the properties of the glucagon stimulation test (GST) and the normal meal tolerance test (NMTT) in patients with type 2 diabetes. MATERIALS AND METHODS: We enrolled 142 patients with type 2 diabetes and performed a GST and a NMTT. We performed the NMTT using a calorie-controlled meal based on an intake of 30 kcal/kg ideal body weight/day. We calculated the change in C-peptide immunoreactivity (ΔCPR) by subtracting fasting CPR from the CPR 6 min after the 1 mg glucagon injection (GST) or 120 min after the meal (NMTT)...
May 11, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28494142/blood-pressure-circadian-rhythms-and-adverse-outcomes-in-type-2-diabetics-diagnosed-with-orthostatic-hypotension
#5
Jing Chang, Yuan-Ping Hou, Jin-Ling Wu, Xiang-Yang Fang, Sheng-Li Li, Miao-Bing Liu, Qian-Mei Sun
AIMS/INTRODUCTION: Patients with diabetes frequently develop orthostatic hypotension (OH). The present study was designed to examine the relationship of blood pressure (BP) circadian rhythms and outcomes in diabetes with OH. MATERIALS AND METHODS: In this study, 173 inpatients with type 2 diabetes were enrolled. Subjects were divided into an OH group and a non-OH group according to the BP changes detected in supine and standing position. 24-h ambulatory blood pressure was monitored...
May 11, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28494126/real-life-glycemic-control-in-patients-with-type-2-diabetes-treated-with-insulin-therapy-a-prospective-longitudinal-cohort-study-diabetes-distress-and-care-registry-at-tenri-ddcrt-9
#6
Naotaka Fujita, Yosuke Yamamoto, Yasuaki Hayashino, Hirohito Kuwata, Shintaro Okamura, Tadao Iburi, Miyuki Furuya, Masako Kitatani, Shin Yamazaki, Hitoshi Ishii, Satoru Tsujii, Nobuya Inagaki, Shunichi Fukuhara
AIMS/INTRODUCTION: We investigated the association between four insulin regimens and increase in HbA1c and insulin dose in a real-life clinical setting because there is no data about them among insulin regimens. MATERIALS AND METHODS: Subjects included 757 patients with type 2 diabetes having been treated with insulin therapy for more than 1 year. The four insulin regimens were regimen 1 (long-acting insulin, once daily), regimen 2 (biphasic insulin, twice daily), regimen 3 (biphasic insulin, three times daily), and regimen 4 (basal-bolus therapy)...
May 11, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28477380/antibodies-against-h1n1-influenza-virus-cross-react-with-alpha-cells-of-pancreatic-islets
#7
Zongli Qi, Hanyu Hu, Zhihua Wang, Guanghua Wang, Yan Li, Xiangrong Zhao, Yangmeng Feng, Xueping Huo, Jingying Sun, Qing Feng, Yang Liu, Nana Wang, Chunyan Guo, Yuan Li, Ruian Wang, Jun Hu
Epidemiological studies have documented that the incidence of human type 1 diabetes (T1D) is significantly increased after H1N1 epidemic. However, direct link between T1D and virus infection remains elusive. We generated 84 clones of murine mAbs against the H1N1 and performed immunohistochemistry in normal human tissue microarray. The results demonstrated that two clones specifically cross-reacted with human pancreatic tissues α cell of pancreatic islet. RT-PCR and DNA sequencing showed that the amino acid sequences of light and heavy chains of these clones were different...
May 6, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28445618/ficolin-3-adiponectin-ratio-for-the-prediction-of-gestational-diabetes-mellitus-in-pregnant-women
#8
Xiao-Song Yuan, Hui Shi, Hui-Yan Wang, Bin Yu, Jian Jiang
AIMS/INTRODUCTION: To establish that the ficolin-3/adiponectin ratio is a predictor for gestational diabetes mellitus (GDM) and was eligible for screening tests for GDM. MATERIALS AND METHODS: A prospective cohort study of 86 pregnant women who developed GDM and 273 normal glucose tolerance (NGT) participants was performed. Maternal serum ficolin-3, adiponectin levels were investigated at 16-18 weeks gestation using ELISA. RESULTS: Compared to the NGT group, the GDM group showed significantly higher levels of ficolin-3 and the ratio of ficolin-3/adiponectin; and decreased levels of adiponectin between 16 to 18 weeks of gestation (P < 0...
April 26, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28434196/role-of-gut-microbiota-bile-acids-and-their-crosstalk-in-the-effects-of-bariatric-surgery-on-obesity-and-type-2-diabetes
#9
Haijun Liu, Cheng Hu, Xueli Zhang, Weiping Jia
Type 2 diabetes mellitus is becoming increasingly prevalent worldwide and has become one of the greatest threats to global health. Bariatric surgery was initially designed to achieve weight loss and subsequently was noted to induce improvements or remission of type 2 diabetes. Currently, these bariatric operations such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are the most effective procedures for the treatment of obesity and type 2 diabetes mellitus worldwide. However, the specific mechanism mediating the beneficial effects of metabolic surgery has remained largely unknown...
April 23, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28429860/safety-tolerability-and-efficacy-of-lixisenatide-in-combination-with-oral-antidiabetic-treatment-in-japanese-patients-with-type-2-diabetes-an-open-label-multicenter-study
#10
Yutaka Seino, Aleksandra Stjepanovic, Akane Takami, Hiroki Takagi
AIM/INTRODUCTION: To assess overall safety and efficacy of lixisenatide in combination with background oral antidiabetic drug treatment in Japanese patients with type 2 diabetes, as required by Japanese guidelines. MATERIALS AND METHODS: A Phase 3, multicenter, uncontrolled, open-label, four-arm, parallel-group study in Japanese outpatients with type 2 diabetes; patients received once-daily lixisenatide in combination with biguanide, thiazolidinedione, alpha-glucosidase inhibitors, or glinide (NCT01940965)...
April 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28429854/application-of-3c-insulin-pump-system-in-combination-with-non-invasive-ventilation-in-the-treatment-of-a-patient-with-type-2-diabetes-and-obstructive-sleep-apnea-syndrome
#11
Peng Dong, Jing Xu, Junhong Wang, Chunhong Zhang
We observed the curative effect of 3C insulin system in combination with non-invasive ventilation in a patient with type 2 diabetes and obstructive sleep apnea syndrome (OSAS). 3C insulin pump is a system of devices that closely monitors and effectively regulates blood glucose levels. Non-invasive ventilation has been shown to be an effective treatment for OSAS. A type 2 diabetic patient with concomitant OSAS was treated with a 3C insulin pump system for real-time continuous glucose monitoring and nocturnal non-invasive ventilation for OSAS...
April 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28429513/distribution-and-hormonal-characterization-of-primary-murine-l-cells-throughout-the-gastrointestinal-tract
#12
Kazuyo Suzuki, Kanako Iwasaki, Yuki Murata, Norio Harada, Shunsuke Yamane, Akihiro Hamasaki, Kimitaka Shibue, Erina Joo, Akiko Sankoda, Yuta Fujiwara, Yoshitaka Hayashi, Nobuya Inagaki
AIMS/INTRODUCTION: Glucagon-like peptide-1 (GLP-1) secreted from enteroendocrine L-cells is an incretin that potentiates insulin secretion and is already applied in therapies for type 2 diabetes. However, detailed examination of L-cells throughout the gastrointestinal (GI) tract remains unclear, because of difficulties in purifying scattered L-cells from other cells. In the present study, we identified characteristics of L-cells of the upper small intestine (UI), the lower small intestine (LI) and the colon using glucagon (Gcg)-green fluorescent protein (GFP)-expressing mice that express GFP driven by the proglucagon promoter...
April 20, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28418217/24-hour-variations-in-blood-glucose-level-in-type-2-diabetic-japanese-based-on-continuous-glucose-monitoring
#13
Maiko Hajime, Yosuke Okada, Hiroko Mori, Takashi Otsuka, Mayuko Kawaguchi, Megumi Miyazaki, Fumi Kuno, Kei Sugai, Satomi Sonoda, Kenichi Tanaka, Akira Kurozumi, Manabu Narisawa, Keiichi Torimoto, Tadashi Arao, Yoshiya Tanaka
AIMS/INTRODUCTION: High fluctuations in blood glucose are associated with various complications. The correlation between glycated hemoglobin (HbA1c) level and fluctuations in blood glucose level has not been studied in Japanese patients with type 2 diabetes (T2DM). In this study, blood glucose profile stratified by HbA1c level was evaluated by continuous glucose monitoring (CGM) in Japanese T2DM patients. MATERIALS AND METHODS: Our retrospective study included 294 patients with T2DM, who were divided by HbA1c level into five groups (≥6...
April 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28418115/aggravation-of-diabetes-and-incompletely-deficient-insulin-secretion-in-a-case-with-type-1-diabetes-resistant-hla-drb1-15-02-treated-with-nivolumab
#14
Kimio Matsumura, Kaoru Nagasawa, Yoichi Oshima, Shouta Kikuno, Kyohei Hayashi, Akihiro Nishimura, Minoru Okubo, Hironori Uruga, Kazuma Kishi, Tetsuro Kobayashi, Yasumichi Mori
Anti-programmed cell death-1 (PD-1) antibody therapy induces various adverse effects especially in endocrine systems. Several cases of acute onset insulin-dependent diabetes after anti-PD-1 antibody therapy have been reported. Many of these cases have a susceptible HLA genotype for type 1 diabetes possibly suggesting that human leukocyte antigen (HLA) might be involved in the onset of diabetes with anti PD-1 therapy. We describe an atypical case of hyperglycemia after anti PD-1 antibody administration. A 68-year-old Japanese man with pancreatic diabetes and steroid diabetes was administered nivolumab three times for chemoresistant adenocarcinoma of the lung...
April 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28406580/low-glucose-induces-mitochondrial-reactive-oxygen-species-via-fatty-acid-oxidation-in-bovine-aortic-endothelial-cells
#15
Nobuhiro Kajihara, Daisuke Kukidome, Kiminori Sada, Hiroyuki Motoshima, Noboru Furukawa, Takeshi Matsumura, Takeshi Nishikawa, Eiichi Araki
AIMS/INTRODUCTION: Overproduction of reactive oxygen species (ROS) in endothelial cells (ECs) plays a pivotal role in endothelial dysfunction. Mitochondrial ROS (mtROS) is one of the key players in the pathogenesis of diabetic vascular complications. Hypoglycemia is linked to increased ROS production and vascular events; however, the underlying mechanisms remain unclear. In the present study, we aimed to determine whether and how low glucose (LG) mediates mtROS generation in ECs, and to examine the impact of LG-induced mtROS on endothelial dysfunction...
April 12, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28397367/continuous-glucose-monitoring-reveals-hypoglycemia-risk-in-elderly-patients-with-type-2-diabetes-mellitus
#16
Takahiro Ishikawa, Masaya Koshizaka, Yoshiro Maezawa, Minoru Takemoto, Yoshiharu Tokuyama, Toshihiro Saito, Koutaro Yokote
AIMS/INTRODUCTION: The incidence of type 2 diabetes is higher in elderly patients, in whom this disease is associated with dementia, falling, stroke and death. We utilized a continuous glucose monitoring device to analyze the relationship between hypoglycemia and diabetes treatments to identify risk factors for hypoglycemia (defined as a blood glucose level <70 mg/dL). MATERIALS AND METHODS: We classified 170 patients aged ≥65 years with type 2 diabetes who were receiving steady-state medication (29 of whom were inpatients) into hypoglycemic and non-hypoglycemic groups, and compared their glycosylated hemoglobin levels, treatment types, continuous glucose monitoring data and other parameters...
April 11, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28390105/marked-alteration-of-glycemic-profile-surrounding-lanreotide-administration-in-acromegaly-a-case-report
#17
Sho Tanaka, Akira Haketa, Shun Yamamuro, Toshiko Suzuki, Hiroki Kobayashi, Yoshinari Hatanaka, Takahiro Ueno, Noboru Fukuda, Masanori Abe, Atsuo Yoshino, Masayoshi Soma
Whether somatostatin analogs for acromegaly improve or worsen a patient's glycemic profile is controversial. A risk of hypoglycemia should be presumed especially when patients receive insulin therapy, as the package inserts caution. However, a detailed clinical course of such a case was never reported in research articles. An 80-year-old Japanese female diabetic treated with insulin therapy was diagnosed with acromegaly, and the somatostatin analog, lanreotide, was administered. On day 4 of administration, repeated hypoglycemia due to exogenous insulin arose and the patient required inpatient care...
April 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28390099/subcutaneous%C3%A2-injection-of-h2-is-a-novel-effective-treatment-for-type-2-diabetes
#18
Xiaolong Zhang, Jiaming Liu, Keke Jin, Haifeng Xu, Chuang Wang, Zhuang Zhang, Mimi Kong, Zhengzheng Zhang, Qingyi Wang, Fangyan Wang
AIMS/INTRODUCTION: In previous studies H2 administration has clearly shown effectiveness in inhibiting diabetes. Here, we evaluated whether subcutaneous injection of H2 shows enhanced efficacy against type 2 diabetes mellitus (T2DM) induced in mice by a high-fat diet and low dose streptozotocin (STZ) treatment. MATERIAL AND METHODS: H2 was injected subcutaneously at a dose of 1ml/mouse/week for four weeks. T2DM associated parameters were then evaluated to determine the effectiveness of subcutaneous H2 administration...
April 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28390093/understanding-the-role-of-the-gut-ecosystem-in-diabetes-mellitus
#19
REVIEW
Wanping Aw, Shinji Fukuda
Diabetes mellitus is a type of metabolic disorder whereby patients are unable to regulate glycemia. It is currently a worldwide public health issue, and is a burden to society because of its disabling and common complications. Diabetes is multifactorial, and also induces the onset of other diseases. In the present report, we review the labyrinth encompassing the gut microbiota and gut microbiota-derived metabolites in type 1 diabetes and type 2 diabetes pathogenesis. There have been exceptional improvements in deoxyribonucleic acid sequencing and mass spectrometry technologies throughout these past years, and these have allowed the comprehensive collection of information on our unique gut ecosystem...
April 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28387061/gestational-diabetes-mellitus-and-first-trimester-pregnancy-associated-plasma-protein-a-a-case-control-study-in-a-chinese-population
#20
Di Xiao, Chenhong Wang, Yanbin Xu, Zhou Lu
AIMS: To investigate the relationship between pregnancy-associated plasma protein A (PAPP-A) and gestational diabetes mellitus (GDM) and to determine whether PAPP-A has improved value for predicting GDM in a Chinese population. METHODS: Clinical data for 599 GDM patients and 986 unaffected pregnant women undergoing both antenatal examinations and delivery were retrospectively analyzed. First-trimester serum PAPP-A levels were compared between the groups. Binary logistic regression analysis was used to explore the risk factors for GDM, and the area under the receiver operating characteristic (AUC-ROC) curve was used to determine the value of PAPP-A for predicting GDM...
April 7, 2017: Journal of Diabetes Investigation
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