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Journal of Diabetes Investigation

Yutaka Seino, Yasuo Terauchi, Xiangling Wang, Daisuke Watanabe, Elisabeth Niemoeller
AIM/INTRODUCTION: To assess overall safety of lixisenatide monotherapy in Japanese patients with type 2 diabetes mellitus. MATERIALS AND METHODS: Patients with type 2 diabetes mellitus, previously treated with ≤1 oral antidiabetic drugs, were enrolled in an uncontrolled, open-label, single-arm study over 24 and 52 weeks. Any oral antidiabetic drug treatment was stopped at the start of the 6-week run-in period. From baseline, patients received once-daily lixisenatide monotherapy (10 μg for 1 week, 15 μg for 1 week, 20 μg thereafter) for 52 weeks (first 140 patients enrolled) or 24 weeks (subsequently enrolled patients)...
February 13, 2017: Journal of Diabetes Investigation
Yasuo Ohashi, Michael Lyng Wolden, Jacob Hyllested-Winge, Meryl Brod
AIMS: This study investigated the impact of non-severe hypoglycaemic events (NSHE) on patients' diabetes management, daily functioning and well-being. METHODS: A survey assessing the impact of NSHEs was completed by insulin-treated Japanese people with diabetes, aged ≥20 years with self-reported diabetes, who had experienced at least one NSHE in the last 3 months. Survey questions captured reasons for and length of the event, and impacts on diabetes management, daily functioning, sleep and well-being...
February 8, 2017: Journal of Diabetes Investigation
Hiroyo Ninomiya, Naoto Katakami, Taka-Aki Matsuoka, Mitsuyoshi Takahara, Hitoshi Nishizawa, Norikazu Maeda, Michio Ohtsuki, Akihisa Imagawa, Hiroyasu Iso, Tetsuya Ohira, Iichiro Shimomura
AIMS/INTRODUCTION: It is suggested that positive psychosocial condition has a good effect on health and glycemic control. However, there has been no research to evaluate the association between positive psychosocial factors and diabetic nephropathy (DN). The aim of this study was to evaluate the association between psychosocial factors and DN in patients with type 2 diabetes. MATERIAL AND METHODS: To assess psychosocial condition, 6 indicators (Happiness score, LOT-R score as an indicator of dispositional optimism, Laughter frequency, Self-awareness of stress, Social network, and Social support) were assessed by self-administered questionnaire, and associations between these psychosocial indicators and the presence of DN were examined...
February 8, 2017: Journal of Diabetes Investigation
Shiro Fukuda, Ayumu Hirata, Hitoshi Nishizawa, Hirofumi Nagao, Takekazu Kimura, Yuya Fujishima, Masaya Yamaoka, Junji Kozawa, Akihisa Imagawa, Tohru Funahashi, Norikazu Maeda, Iichiro Shimomura
Sleep pattern has been shown to associate with type 2 diabetes mellitus (T2DM). Here, we investigated the difference in bedtime, waking time, and estimated sleep duration in T2DM patients with or without visceral fat accumulation, using questionnaire on sleep patterns. The study subjects were 59 Japanese T2DM patients (males/females = 34/25, age 64.5 ± 12.1 years, mean ± SD). Visceral fat accumulation was defined as estimated visceral fat area ≥100cm(2) . The patients with visceral fat accumulation (N=40) showed significantly later bedtime (23:51 ± 1:27 in (+) group vs 22:49 ± 1:23 in (-) group) and shorter estimated sleep duration (6...
February 8, 2017: Journal of Diabetes Investigation
Atsunori Kashiwagi, Hiroshi Maegawa
The specific Na+/glucose co-transporter 2 inhibitors (SGLT2 inhibitors) inhibit glucose reabsorption in proximal renal tubular cells, and both fasting and postprandial glucose significantly decrease due to urinary glucose loss. As a result, pancreatic β-cell function and peripheral insulin action significantly improve with relief from glucose toxicity. Furthermore, whole body energy metabolism changes to relative glucose deficiency and triggers increased lipolysis in fat cells, and fatty acid oxidation and then ketone body production in the liver during treatment with SGLT2 inhibitors...
February 8, 2017: Journal of Diabetes Investigation
Jizhong Shen, Yun Fang, Huaijun Zhu, Weihong Ge
AIMS: The objective of this study was to investigate the relations between plasma interleukin-22 (IL-22) levels and prediabetes or Type 2 diabetes (T2DM) and search the relevance between plasma concentrations of IL-22 and selected diabetes risk factors in Chinese people. MATERIALS AND METHODS: The Han Chinese origin men and women subjects were recruited in our study during a conventional medical checkup. Fasting plasma IL-22 levels were detected by ELISA and their relevance with selected diabetes risk factors was explored...
February 7, 2017: Journal of Diabetes Investigation
Liu Gao, Lingling Bai, Min Shi, Jingxian Ni, Hongyan Lu, Yanan Wu, Jun Tu, Xianjia Ning, Jinghua Wang, Yukun Li
AIMS: Carotid intima-media thickness (CIMT) is an established predictor of cardiovascular disease and stroke. We aimed to identify the association between CIMT and blood glucose as well as the risk factors associated with increased CIMT in a low-income Chinese population. MATERIALS AND METHODS: Stroke-free and cardiovascular disease-free residents aged ≥45 years were recruited. B-mode ultrasonography was performed to measure CIMT. RESULTS: There were 2643 participants (71...
February 3, 2017: Journal of Diabetes Investigation
Eri Takahashi, Hiroyuki Unoki-Kubota, Yukiko Shimizu, Tadashi Okamura, Wakiko Iwata, Hiroshi Kajio, Ritsuko Yamamoto-Honda, Tomoko Shiga, Shigeo Yamashita, Kazuyuki Tobe, Akinori Okumura, Michihiro Matsumoto, Kazuki Yasuda, Mitsuhiko Noda, Yasushi Kaburagi
AIM: To identify candidate serum molecules associated with the progression of type 2 diabetes mellitus (T2DM), differential serum proteomic analysis was performed on a spontaneous animal model of T2DM without obesity, the Long-Evans Agouti (LEA) rat. MATERIALS AND METHODS: We performed quantitative proteomic analysis using serum samples from 8- and 16-week-old LEA and control Brown Norway (BN) rats (n=4/group). Differentially expressed proteins were validated by multiple reaction monitoring (MRM) analysis using the sera collected from 8-, 16- and 24-week-old LEA (n = 4/each group) and BN rats [n = 5/each group]...
February 2, 2017: Journal of Diabetes Investigation
Takeshi Kurose, Yoshiyuki Hamamoto, Yutaka Seino
Recent major progress in clinical management of type 2 diabetes mellitus has been accomplished with the introduction of several new classes of drugs, some of which may also improve cardiovascular outcomes. Most of these studies are supported by pharmaceutical companies and claim CV (cardiovascular) benefits. However whether or not these benefits hold in clinical settings is dubious. This article is protected by copyright. All rights reserved.
January 28, 2017: Journal of Diabetes Investigation
Rimei Nishimura, Hironari Sano, Yoshiko Onda, Daisuke Tsujino, Kiyotaka Ando, Futoshi Ebara, Toru Matsudaira, Shinichiro Ishikawa, Takuya Sakamoto, Naoko Tajima, Kazunori Utsunomiya
INTRODUCTION: Little information is available regarding the status of insulin resistance (IR) and insulin deficiency (ID) as well as their relationship with obesity in children using the homeostasis model assessment (HOMA) in a population-based setting. MATERIALS AND METHODS: The study included a total of 445 ninth-grade children participating in health check-up programs implemented in Tsunan Town, Niigata (boys/girls, 252/193 [participation rates: 98.1%/95.5%])...
January 28, 2017: Journal of Diabetes Investigation
Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Isao Minami, Takanobu Yoshimoto, Yoshihiro Ogawa
Sarcopenia, defined as age-related loss of skeletal muscle mass and function, increases the risk of albuminuria. However, it has still unknown whether sarcopenia could increase the risk for the progression of albuminuria. A total 238 patients with type 2 diabetes (mean age 64 ± 12 years; 39.2% female) were studied in this retrospective observational study. Prevalence of sarcopenia was 17.6%. During the median follow-up period of 2.6 years, albuminuria was measured 5.8 ± 1.8 times and progression of albuminuria was observed in 14...
January 28, 2017: Journal of Diabetes Investigation
Elif I Ekinci, Niloufar Torkamani, Sabashini K Ramchand, Leonid Churilov, Ken A Sikaris, Zhong X Lu, Christine A Houlihan
It is unknown if high prolactin levels during pregnancy contribute to the development of gestational diabetes. We hypothesized that higher prolactin levels are associated with reduced glucose tolerance, as determined by higher 2-hour glucose level from an oral glucose tolerance test (OGTT) in pregnancy. 75 gram OGTT was performed at 28 weeks of gestation in 69 participants. A multiple regression analysis was used to determine the relationship between serum prolactin and 2-hour glucose levels. Multivariable regression analysis demonstrated an independent and significant relationship between third trimester prolactin and 2-hour glucose levels post OGTT...
January 27, 2017: Journal of Diabetes Investigation
Hiroshi Nitta, Sayaka Katagiri, Toshiyuki Nagasawa, Yuichi Izumi, Isao Ishikawa, Hajime Izumiyama, Isao Uchimura, Masao Kanazawa, Hiroshige Chiba, Akira Matsuo, Kazunori Utsunomiya, Haruyasu Tanabe, Izumi Takei, Soichiro Asanami, Hiroshi Kajio, Toaki Ono, Yoichi Hayashi, Kiichi Ueki, Masatomi Tsuji, Yoichi Kurachi, Toshikazu Yamanouchi, Yoshimi Ichinokawa, Toshiki Inokuchi, Akiko Fukui, Shigeru Miyazaki, Takashi Miyauchi, Reiko Kawahara, Hideki Ogiuchi, Narihito Yoshioka, Jun Negishi, Masatomo Mori, Kenji Mogi, Yasushi Saito, Hideki Tanzawa, Tetsuo Nishikawa, Norihiko Takada, Kishio Nanjo, Nobuo Morita, Naoto Nakamura, Narisato Kanamura, Hirofumi Makino, Fusanori Nishimura, Kunihisa Kobayashi, Yoshinori Higuchi, Toshiie Sakata, Shigetaka Yanagisawa, Chuwa Tei, Yuichi Ando, Nobuhiro Hanada, Shuji Inoue
AIMS/INTRODUCTION: To explore the relationships between periodontitis and microvascular complications as well as glycemic control in type 2 diabetic patients. MATERIALS AND METHODS: This multi-center hospital-based cross-sectional study included 620 patients with type 2 diabetes. We compared the prevalence and severity of periodontitis between patients with ≥1 microvascular complication and those without microvascular complications. We also compared the prevalence and severity of periodontitis among patients with different degrees of glycemic control...
January 27, 2017: Journal of Diabetes Investigation
Yasuyuki Mitama, Saeko Fujiwara, Masayasu Yoneda, Sakurako Kira, Nobuoki Kohno
AIMS/INTRODUCTION: There are various causes of incident bone fracture. Not only aging, low bone mineral density and history of previous fracture, but also diabetes mellitus (DM) and inflammation are regarded as the risk of fracture. The purpose of this study is to verify the association of glycemic control or one inflammatory marker with incident fracture in a large-scale Japanese cohort. MATERIALS AND METHODS: This study was conducted at the Hiroshima Atomic Bomb Casualty Council and included 6,556 participants (2,785 men and 3,771 women, age 55-87) who underwent annual health examination followed for 7...
January 25, 2017: Journal of Diabetes Investigation
Dian He, Shaowen Wu, Haiping Zhao, Hongyan Qiu, Yang Fu, Xingming Li, Yan He
AIMS/INTRODUCTION: This Meta-analysis was conducted to assess the association between exposure to the level of atmospheric particulate matter 2.5 (PM2.5, fine particulate matter with aerodynamic diameter less than 2.5 μm) with type 2 diabetes mellitus (T2DM) or gestational diabetes mellitus (GDM). MATERIALS AND METHODS: We searched the Medline, EMBASE, Cochrane and Web of Science databases to obtain articles according to the responding literature search strategies...
January 25, 2017: Journal of Diabetes Investigation
Lin Han, Yuxia Ma, Suhong Wei, Jinhui Tian, Xiaochun Yang, Xiping Shen, Jun Zhang, Yuexian Shi
AIMS: Previous reviews have revealed uncertainty regarding the effectiveness of home visit interventions for managing diabetes. Therefore, we performed a quantitative systematic review and meta-analysis to evaluate the effects of home visit interventions among patients with diabetes. METHODS: We searched various electronic databases (PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, Wanfang, and Chinese scientific full-text databases) from their inception until March 2016...
January 21, 2017: Journal of Diabetes Investigation
Yujiro Ina, Yumiko Kawabata, Ryuichi Sakamoto, Naotaka Sekiguchi, Hiroshi Ikegami
Multiplex families with type 1 diabetes are important for identification of rare variants that cannot be identified in case-control association studies. Very low incidence of type 1 diabetes in Japanese population, however, makes identification of such families difficult. We identified a Japanese family in which three members developed type 1 diabetes, and studied the genotype of the HLA. All three members with type 1 diabetes had the DRB1*08:02-DQB1*03:02 haplotype, which is specific to the Asian population and strongly susceptible for type 1 diabetes...
January 20, 2017: Journal of Diabetes Investigation
Li-Jing Sun, Yan-Ni Sun, Jian-Ping Shan, Geng-Ru Jiang
AIMS: We aimed to evaluate the potential benefits and adverse effects of adding a mineralocorticoid receptor antagonist (MRA) to angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin receptor blockers (ARB), as standard treatment in patients with DN. MATERIALS AND METHODS: We scanned the Embase, PubMed, and Cochrane Central Register of Controlled Trials databases for human clinical trials published in English until June 2016, evaluating renal outcomes in patients with DN...
January 20, 2017: Journal of Diabetes Investigation
Kazunori Utsunomiya, Naoki Shimmoto, Masayuki Senda, Yuji Kurihara, Ryoji Gunji, Shoko Fujii, Seigo Kakiuchi, Hisataka Fujiwara, Hiroyuki Kameda, Masahiro Tamura, Kohei Kaku
AIMS/INTRODUCTION: While sodium glucose cotransporter 2 inhibitors are a promising treatment for type 2 diabetes mellitus, they are associated with concerns about specific adverse drug reactions. We conducted a 1-year post-marketing study of tofogliflozin, a novel agent in this class, in Japanese elderly patients with type 2 diabetes mellitus. MATERIALS AND METHODS: This was a prospective, observational, and multicenter post-marketing study conducted in the context of routine clinical practice...
January 20, 2017: Journal of Diabetes Investigation
Xiaoling Cai, Liwei Ji, Yifei Chen, Wenjia Yang, Lingli Zhou, Xueyao Han, Simin Zhang, Linong Ji
To evaluate the efficacy of weight changes from baseline of the SGLT2 inhibitors treatment and GLP-1 analogs treatment after comparisons with placebo in type 2 diabetes patients and the associated factors MATERIALS AND METHODS: Studies were searched from when recording began, June 2004, until June 2015, and re-searched on July 2016, and placebo-controlled randomized trials in type 2 diabetes patients with a study length ≥12 weeks were included RESULTS: A total of 97 RCTs were included. Compared with placebo, treatment with SGLT2 inhibitors was associated with a significant greater decrease in weight change from baseline, (weighted mean differences (WMD), -2...
January 20, 2017: Journal of Diabetes Investigation
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