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Journal of Diabetes Investigation

Riccardo Calafiore
When Anthony Sun (1) showed, for the first time in 1980, that intraperitoneal graft of allogeneic rat pancreatic islet containing alginate-poly-L-lysine microcapsules, reversed hyperglycemia in not immunosuppressed diabetic rats, a new era for the cell therapy of diabetes had started. As a unique and unmatched result, years later, Sun replied success in diabetic primates, that upon intraperitoneal transplant of microencapsulated porcine islets, showed long-term remission of hyperglycemia. However, at that time, the international academic and scientific community greeted with skepticism such a revolutionary approach...
December 7, 2017: Journal of Diabetes Investigation
Yun Kyung Cho, Ye-Jee Kim, Yu Mi Kang, Seung Eun Lee, Joong-Yeol Park, Woo Je Lee, Chang Hee Jung
AIMS/INTRODUCTION: We aimed to evaluate the efficacy and safety of pioglitazone (PIO) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) as additions to insulin therapy for the management of type 2 diabetes mellitus (T2D). MATERIALS AND METHODS: We searched PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, and ClinicalTrials. gov through December 2016. Randomized controlled trials (RCTs) published in English that compared SGLT2i plus insulin (SGLT2i/INS) or PIO plus insulin (PIO/INS) with placebo plus insulin (PCB/INS) in T2D patients were included...
December 7, 2017: Journal of Diabetes Investigation
Yali Jing, Ting Hong, Yan Bi, Dayi Hu, Guojuan Chen, Jihu Li, Ye Zhang, Ruya Zhang, Linong Ji, Dalong Zhu
AIMS: To investigate the prevalence and risk factors of Metabolic Syndrome (MetS) in Chinese type 2 diabetes mellitus (T2DM) patients and assess the effect of MetS on the treatment patterns and 3B (blood glucose, blood pressure, blood lipids) goal achievements. MATERIALS AND METHODS: Data from 25,454 T2DM patients including demographic data, anthropometric measurements, treatment patterns and blood glucose and lipid profiles were retrospectively analyzed. RESULTS: Using modified ATP III MetS criteria, the prevalence of MetS was 57...
December 4, 2017: Journal of Diabetes Investigation
Satoshi Ida, Kazuya Murata, Ryutaro Kaneko
AIMS/INTRODUCTION: The aim of the present study was to conduct a meta-analysis of randomized controlled trials (RCTs) that investigated the effects of pioglitazone on blood leptin levels in patients with type 2 diabetes. MATERIALS AND METHODS: Literature searches were performed using Medline, the Cochrane Controlled Trials Registry, and ClinicalTrials. gov, and RCTs that investigated the effects of pioglitazone on blood leptin levels in patients with type 2 diabetes were selected...
December 1, 2017: Journal of Diabetes Investigation
Liehua Liu, Juan Liu, Lijuan Xu, Weijian Ke, Xuesi Wan, Hai Li, Xiaoying He, Liangjiao Wang, Xiaopei Cao, Haipeng Xiao, Yanbing Li
AIMS/INTRODUCTION: Optimal glycemic targets during short-term intensive insulin therapy in patients with newly diagnosed type 2 diabetes were not standardized. This study is performed to determine the optimal glycemic targets during the therapy by analyzing the impacts of glucose levels on therapeutic outcomes. MATERIALS AND METHODS: Nighty-five subjects with newly diagnosed type 2 diabetes were enrolled. Short-term intensive insulin therapy was carried out using insulin pump to achieve and maintain glycemic targets (FBG< 6...
November 30, 2017: Journal of Diabetes Investigation
Sachiko Hattori
AIMS/INTRODUCTION: Remnant lipoproteins are thought to be atherogenic. Remnant-like particle cholesterol (RLP-C), which reflects the levels of various kinds of remnant lipoproteins in the blood, has a significant correlation with insulin resistance. MATERIALS AND METHODS: In this study, we measured the effect of empagliflozin (EMPA) on the levels of RLP-C and investigated whether EMPA-mediated change in RLP-C is associated with a change in insulin resistance in type2 diabetic patients who have insulin resistance...
November 28, 2017: Journal of Diabetes Investigation
Haoyu Wang, Fadong Yu, Zhuo Zhang, Yuanyuan Hou, Weiping Teng, Zhongyan Shan, Yaxin Lai
OBJECTIVES: The member B of the family with sequence similarity 3 (FAM3B), also known as pancreatic-derived factor, is mainly synthesized and secreted by islet β-cells, and play a role in abnormal metabolism of glucose and lipid. However, the prospective association of FAM3B with metabolic disorders remain uncovered. This study aimed to reveal the predictive relationship between pancreas-specific cytokine and metabolic syndrome (MetS). MATERIALS AND METHODS: 210 adults (88 males and 122 females) without MetS, aged between 40 and 65, were recruited and received a comprehensive healthy examination...
November 27, 2017: Journal of Diabetes Investigation
Hitoshi Kuwata, Saki Okamoto, Yusuke Seino, Kenta Murotani, Hisato Tatsuoka, Ryota Usui, Yoshiyuki Hamamoto, Takeshi Kurose, Yutaka Seino, Daisuke Yabe
This study was designed to assess possible relationships between deterioration of the HbA1c-lowering effects in dipeptidyl peptidase-4 inhibitor (DPP4i) monotherapy and macronutrient intake among individuals with type 2 diabetes (T2D). T2D individuals who began and continued DPP4i monotherapy without any prescription change for 1 year were retrospectively stratified into two groups: patients who maintained their HbA1c levels during the 0.5- to 1-year period after DPP4i initiation [Group A, ΔHbA1c (1-0.5 year)<0...
November 24, 2017: Journal of Diabetes Investigation
Yuika Ikeda, Takekazu Kubo, Eisei Oda, Machiko Abe, Shigeru Tokita
AIMS: To evaluate the incidence rate of and identify factors associated with severe hypoglycemic episodes in patients with treated T2DM. METHODS: Using Diagnosis Procedure Combination (DPC) hospital-based medical database, we performed a retrospective cohort study to assess the incidence rate of severe hypoglycemia in treated T2DM patients. We evaluated the associations between severe hypoglycemia and age, sex, complications and current use of insulin or sulfonylurea (SU) in a nested case control study...
November 24, 2017: Journal of Diabetes Investigation
Sakiko Yoshida, Teruki Miyake, Shin Yamamoto, Shinya Furukawa, Tetsuji Niiya, Hidenori Senba, Sayaka Kanzaki, Osamu Yoshida, Toru Ishihara, Mitsuhito Koizumi, Masashi Hirooka, Teru Kumagi, Masanori Abe, Kohichiro Kitai, Bunzo Matsuura, Yoichi Hiasa
AIMS/INTRODUCTION: The association between urine pH and abnormal glucose tolerance in men and women is unclear; therefore, we conducted a community-based, cross-sectional study to investigate sex-specific associations between these values, possible indicators of prediabetes, and type 2 diabetes. MATERIALS AND METHODS: We enrolled 4,945 Japanese subjects (2,490 men and 2,455 women), who had undergone annual health checkups. To investigate the relationship between low urine pH and abnormal glucose tolerance, subjects were divided into three groups based on their fasting plasma glucose levels (<6...
November 16, 2017: Journal of Diabetes Investigation
Chia-Hsuin Chang, Lee-Ming Chuang
In 2008, the U.S. Food and Drug Administration requested that all new type 2 anti-diabetic drugs, including long-acting insulin analogues, need to be rigorously examined to preclude undesirable cardiovascular risks. The Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial is the first trial to provide conclusive evidence of the cardiovascular safety of insulin glargine. A total of 12,537 people with cardiovascular risk factors plus impaired fasting glucose, impaired glucose tolerance, or type 2 diabetes were randomized to receive insulin glargine or standard care...
November 15, 2017: Journal of Diabetes Investigation
Meng Wang, Ru-Ying Hu, Hao Wang, Wei-Wei Gong, Chun-Mei Wang, Kai-Xu Xie, Zheng-Ming Chen, Yu Guo, Min Yu, Li-Ming Li
AIMS: There has been considerable professional debate on the association between age at menopause and diabetes risk, while the findings are controversial. This study explored the association between late menopause and the prevalence of diabetes in the Chinese population. MATERIAL AND METHODS: The data were part of the baseline survey of China Kadoorie Biobank from Zhejiang Province. A total of 17,076 postmenopausal women were included in the present study. Logistic regression models were used to calculate the adjusted odds ratios (ORs) and their 95% confidence intervals (CIs)...
November 14, 2017: Journal of Diabetes Investigation
Tomohiko Kimura, Junpei Sanada, Masashi Shimoda, Hidenori Hirukawa, Yoshiro Fushimi, Momoyo Nishioka, Tomoe Kinoshita, Seizo Okauchi, Atsushi Obata, Kenji Kohara, Fuminori Tatsumi, Shinji Kamei, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
AIMS/INTRODUCTION: Sodium-glucose cotransporter 2 (SGLT2) inhibitors function to increase urinary glucose excretion and improve glycemic control in individuals with type 2 diabetes mellitus. SGLT2 inhibitors, as well as diuretics, increase urinary volume, which leads to the reduction of blood pressure. The aim of the present study was to compare the effects of SGLT2 inhibitor and thiazide diuretic on blood pressure, metabolic parameters and body mass composition. MATERIALS AND METHODS: A total of 31 participants were enrolled in the present study...
November 7, 2017: Journal of Diabetes Investigation
Yusuke Kameda, Tetsuya Babazono, Yasuko Uchigata, Shigehiko Kitano
This study aimed to determine whether intravitreal administration of vascular endothelial growth factor inhibitors is associated with deterioration of renal function, as seen with systemic administration, in patients with diabetes and chronic kidney disease. Estimated glomerular filtration rates before and after 160 intravitreal injections of vascular endothelial growth factor inhibitors (aflibercept, bevacizumab, or ranibizumab) were compared in 69 patients with diabetes and with a baseline estimated glomerular filtration rate <60 mL/min/1...
November 6, 2017: Journal of Diabetes Investigation
Ryota Usui, Yui Sakuramachi, Yusuke Seino, Kenta Murotani, Hitoshi Kuwata, Hisato Tatsuoka, Yoshiyuki Hamamoto, Takeshi Kurose, Yutaka Seino, Daisuke Yabe
BACKGROUND AND AIMS: The glucose-lowering effects of the GLP-1 receptor agonist liraglutide have been shown to rely on remaining β-cell function. However, the possible associations of remaining β-cell function with the glucose-lowering effects of liraglutide in combination with basal insulin remain unknown and warrant investigation. METHODS: This is a single-center, retrospective, observational study conducted in a private hospital in Osaka, Japan. Type 2 diabetes patients who received a prescription change from insulin therapy, both multiple-dose insulin (MDI) and basal insulin-supported oral therapy (BOT), to liraglutide/basal insulin combination and continued the therapy for 54 weeks without additional oral anti-diabetic drugs (OAD) or bolus insulin were retrospectively analyzed...
November 6, 2017: Journal of Diabetes Investigation
Shunsuke Kobayashi, Mototsugu Nagao, Akira Asai, Izumi Fukuda, Shinichi Oikawa, Hitoshi Sugihara
AIMS/INTRODUCTION: A prolonged QT interval plays a causal role in life-threatening arrhythmia and becomes a risk factor for sudden cardiac death. Here, we assessed the association between microvascular complications and the QT interval in patients with type 2 diabetes. MATERIALS AND METHODS: Patients with type 2 diabetes (n = 219) admitted to our hospital for glycemic control were enrolled. QT interval was measured manually in lead II on the electrocardiogram and corrected for heart rate using Bazett's formula (QTc)...
November 2, 2017: Journal of Diabetes Investigation
Hitoshi Takagi
Diabetic retinopathy is the most common cause of blindness in adults. Visual deficiency is mainly caused from clinically significant macular edema or vision-threatening proliferative diabetic retinopathy. Recent advances in the treatment modalities such as laser photocoagulation or with intraocular glucocorticoids or anti-vascular endothelial growth factor (VEGF) agents can substantially reduce loss of vision. Since timely application of such treatments is substantial to make a difference in prognostic processes, the goal of retinopathy screening is the timely detection of retinopathy that would, without intervention, cause vision loss...
November 1, 2017: Journal of Diabetes Investigation
Miyako Tanaka, Michiko Itoh, Yoshihiro Ogawa, Takayoshi Suganami
Chronic inflammation is a common molecular basis underlying a variety of chronic diseases. Accumulating evidence has also suggested that chronic inflammation contributes to the pathogenesis of obesity and diabetes, which have been considered as a metabolic disease. For the last several decades, there was a dramatic progress in the underlying mechanism of adipose tissue dysfunction induced by obesity. Tissue remodeling is one of the histological features of chronic inflammation, in which stromal cells dramatically change in number and cell type...
October 31, 2017: Journal of Diabetes Investigation
Zhen Zhang, Keming Li
AIMS: Endothelial cells inflammatory injury is likely required for barrier dysfunction under hyperglycemia condition. Curcumin (CUR) is famous for its anti-inflammatory effect. However, exert few reports about the anti-inflammatory effect of CUR induced by high glucose in endothelial cells. The aim of the present study is to investigate the inflammatory effect of high glucose and the anti-inflammatory effect of CUR induced by high glucose in rat thoracic aorta endothelial cells (TAECs)...
October 28, 2017: Journal of Diabetes Investigation
Dong-Xin Sui, Hui-Min Zhou, Feng Wang, Ming Zhong, Wei Zhang, Yun Ti
AIMS: CIDEC was proven to be closely associated with the development of insulin resistance and metabolic syndrome. We aimed to investigate whether the CIDEC gene silencing could alleviate pulmonary vascular remodeling in a type 2 diabetic rat model. MATERIALS AND METHODS: We built a type 2 diabetic rat model. An adenovirus harboring CIDEC small interfering RNA (siRNA) was then injected via the jugular vein to silence the CIDEC gene. After HE and Sirius red staining, we detected indexes of the pulmonary arterioles remodeling...
October 27, 2017: Journal of Diabetes Investigation
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