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Journal of Diabetes Investigation

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https://www.readbyqxmd.com/read/27896954/effect-of-carbohydrate-counting-using-bolus-calculators-on-glycemic-control-in-type-1-diabetes-patients-during-continuous-subcutaneous-insulin-infusion
#1
Eijiro Yamada, Shuichi Okada, Yasuyo Nakajima, Claire C Bastie, Yuko Tagaya, Aya Osaki, Yoko Shimoda, Ryo Shibusawa, Tsugumichi Saito, Atsushi Ozawa, Masanobu Yamada
This study examined the long-term efficacy of insulin pump therapy for type 1 diabetes patients when performed using carbohydrate counting with bolus calculators for one year. Twenty-two type 1 diabetes patients who had just started continuous subcutaneous insulin infusion were examined and divided into 2 groups: one that was educated about carbohydrate counting using bolus calculators (n=14) and another that did not use bolus calculators (n=8). After one year, the hemoglobin A1c levels of the patient group that used bolus calculators decreased persistently and significantly (P=0...
November 29, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27896943/ang-1-7-protects-cardiomyocytes-against-hg-induced-injuries-through-inhibiting-ros-activated-leptin-p38-mapk-erk1-2-pathways-but-not-leptin-jnk-pathway-in-vitro
#2
Yiyan Lei, Qing Xu, Bo Zeng, Wei Zhang, Yulan Zhen, Yuansheng Zhai, Fei Cheng, Weiyi Mei, Dongdan Zheng, Jianqiang Feng, Jun Lan, Jingfu Chen
AIMS: Angiotensin-(1-7) [Ang-(1-7)], recognized as a new bioactive peptide in renin-angiotensin system (RAS), shows biological and pharmacological properties in diabetic cardiovascular diseases. Leptin induced-p38 MAPK pathway has been reported to contribute to the high glucose (HG)-induced injury. In this study, we demonstrated the mechanism that how Ang-(1-7) can protect from HG-stimulated injuries in H9c2 cells. METHODS: H9c2 cells were treated with 35 mM glucose (HG) for 24 h to establish a model of HG-induced damage...
November 29, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27889950/retinopathy-a-sign-of-cerebral-small-vessel-disease-in-diabetes
#3
Toshitaka Umemura, Takahiko Kawamura
Cardio-cerebrovascular disease greatly influences the prognosis of diabetic patients. Silent lacunar infarcts, white matter lesions (WMLs), and cerebral microbleeds are magnetic resonance imaging (MRI) markers of cerebral small vessel disease (SVD) and as they are associated with stroke and dementia, prevention of their incidence and progression is important in clinical practice. The findings of previous autopsy and clinical studies suggest that lacunar infarcts are more prevalent in diabetic patients. On the other hand, the findings of studies on an association between diabetes and WMLs have been inconsistent...
November 27, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27889949/undercarboxylated-osteocalcin-can-predict-insulin-secretion-ability-in-type-2-diabetes
#4
Yuichi Takashi, Minae Koga, Yoko Matsuzawa, Jun Saito, Masao Omura, Tetsuo Nishikawa
There has been reported to be intimate relationship between diabetes and bone metabolism including undercarboxylated osteocalcin (ucOC). On the other hand, data on the relationship between ucOC and glucose metabolism are limited in type 2 diabetes. We recruited 50 Japanese patients with type 2 diabetes and examined the association with ucOC on the insulin secretion, evaluated by both glucagon loading test (GLT) and meal tolerance test, and the prognosis of diabetes. UcOC was shown to correlate positively with ⊿C-peptide response (CPR) in GLT and CPR after meal taking (p=0...
November 27, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27863115/reversible-splenial-lesion-syndrome-with-a-hyperosmolar-hyperglycemic-state-and-neuroleptic-malignant-syndrome-caused-by-olanzapine
#5
Kenta Kaino, Ryo Kumagai, Shoko Furukawa, Momoko Isono, Aiko Muramatsu, Masanao Fujii, Yumiko Muta, Tomoyuki Asada, Kazuya Fujihara, Hiroaki Yagyu
A 27-year-old woman with panic disorder taking 20 mg olanzapine daily for 4 months was admitted to our hospital because of disturbed consciousness with fever, hyperglycemia, hyperosmolarity, and elevated creatine phosphokinase. She was diagnosed with a hyperosmolar hyperglycemic state (HHS) and neuroleptic malignant syndrome (NMS). Brain magnetic resonance imaging (MRI) showed transiently restricted diffusion in the splenium of the corpus callosum (SCC), with a high signal intensity on diffusion-weighted imaging...
November 18, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27863092/associations-between-changes-in-the-maternal-gut-microbiome-and-differentially-methylated-regions-of-diabetes-associated-genes-in-fetuses-a-pilot-study-from-a-birth-cohort-study
#6
Kaori Tachibana, Kenichi Sakurai, Masahiro Watanabe, Hidenobu Miyaso, Chisato Mori
Several intrauterine environmental factors may increase the future risk of type 2 diabetes. The microbiome can influence the balance between health and disease. However, the influence of the maternal gut microbiome on the future risk of diabetes in the fetus is unknown. The present study investigated the associations between maternal gut microbiome and differentially methylated regions of diabetes-associated genes in umbilical cord samples. This study included 10 pregnant participants from a birth cohort study...
November 18, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27863088/the-relationship-of-hba1c-fasting-and-postprandial-hyperglycemia-in-subjects-with-type-2-diabetes-mellitus-in-malaysia
#7
Lee Ling Lim, Alan Jm Brnabic, Siew Pheng Chan, Luqman Ibrahim, Sharmila Sunita Paramasivam, Jeyakantha Ratnasingam, Shireene Ratna Vethakkan, Alexander Tong Boon Tan
AIMS/INTRODUCTION: Studies on the relative contributions of fasting and postprandial hyperglycemia (FH and PPH) to HbA1c in type 2 diabetes (T2D) subjects have yielded inconsistent results. We aimed to assess the relationship by using continuous glucose monitoring (CGM) in a multi-ethnic cohort. MATERIALS AND METHODS: 100 T2D adults were assessed with 6-day CGM and HbA1c . Area under the curve (AUC) ≥5.6 mmol/L was defined as AUCTOTAL . AUC ≥ each pre-prandial glucose for 4 hours was defined as AUCPPH ...
November 14, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27863109/diagnostic-accuracy-of-the-anti-glutamic-acid-decarboxylase-antibody-in-type-1-diabetes-mellitus-comparison-between-radioimmunoassay-and-enzyme-linked-immunosorbent-assay
#8
Takashi Murata, Kokoro Tsuzaki, Shinsuke Nirengi, Tomokazu Watanabe, Yukako Mizutani, Hayami Okada, Masami Tsukamoto, Shinji Odori, Reiko Nakagawachi, Yaeko Kawaguchi, Fumi Yoshioka, Kazunori Yamada, Akira Shimatsu, Kazuhiko Kotani, Noriko Satoh-Asahara, Naoki Sakane
AIM: The distributer of the anti-glutamic acid decarboxylase (GAD) antibody assay kit using radioimmunoassay (RIA) recently announced its discontinuation and proposed an alternative kit using enzyme-linked immunosorbent assay (ELISA). The aim of the present study was to investigate the diagnostic values of the anti-GAD antibody by RIA and ELISA among type 1 diabetes mellitus patients and control subjects. METHODS: Seventy-nine type 1 diabetes mellitus patients and 79 age-matched controls were enrolled and assessed using RIA and ELISA...
November 10, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27863107/heterogeneity-of-glycometabolism-in-patients-with-gestational-diabetes-mellitus
#9
Yan Yan, Zhou Liu, Daqing Liu
BACKGROUND: To evaluate the glycometabolism and outcomes of gestational diabetes mellitus (GDM) patients according to the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria in China. METHODS: According to the results of a 75-g OGTT, 1683 pregnant women were divided into three groups: an increment GDM group (patients meet the IADPSG criteria but not the previous Chinese criteria), a stock GDM group (patients meet both criteria), and a normal glucose tolerance (NGT) group...
November 10, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27860391/mechanism-of-lipid-lowering-action-of-the-dpp-4-inhibitor-anagliptin-in-ldlr-deficient-mice
#10
Wataru Yano, Noriyuki Inoue, Shiori Ito, Takahiro Itou, Misako Yasumura, Yasunobu Yoshinaka, Sumihiko Hagita, Moritaka Goto, Takashi Nakagawa, Keisuke Inoue, Sohei Tanabe, Kohei Kaku
AIMS/INTRODUCTION: Dipeptidyl peptidase-4 (DPP-4) inhibitors are used for treatment of patients with type 2 diabetes. In addition to glycemic control, these agents showed beneficial effects on lipid metabolism in clinical trials. However, the mechanism underlying the lipid-lowering effect of DPP-4 inhibitors remains unclear. Here, we investigated the lipid-lowering efficacy of anagliptin in a hyperlipidemic animal model, and examined the mechanism of action. MATERIALS AND METHODS: Male LDLR-deficient mice were administered 0...
November 10, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27808480/prevalence-and-characteristics-of-staphylococcus-aureus-and-mrsa-nasal-colonization-among-community-based-diabetes-population-in-foshan-china
#11
Jialing Lin, Ping Xu, Yang Peng, Dongxin Lin, Qianting Ou, Ting Zhang, Chan Bai, Xiaohua Ye, Junli Zhou, Zhenjiang Yao
AIMS: Evidence suggests that diabetes may cause an increase in colonization of Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA) in community settings. We conducted a cross-sectional study to determine the prevalence and influencing factors of S. aureus and MRSA nasal colonization among community-based diabetes population and to identify the characteristics of the isolated strains. MATERIALS AND METHODS: 956 participants from 11 community settings were included in the study...
November 3, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27808477/the-roles-of-p300-and-creb-in-high-glucose-induced-hif-1%C3%AE-inactivation-under-hypoxia-condition
#12
Lingtao Ding, Minlie Yang, Tianlan Zhao, Guozhong Lv
INTRODUCTION: Given the high prevalence of diabetes and burning injury worldwide, it is essential to dissect the underlying mechanism of delayed burn wound healing in diabetic subjects, especially the high glucose induced HIF-1-mediated transcription defects. MATERIALS AND METHODS: Human umbilical vein endothelial cells (HUVECs) were cultured with low or high concentrations of glucose. HIF-1α induced VEGF transcription was measured via luciferase assay. Immunofluorescence staining was performed to visualize CREB localization...
November 3, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27808474/diabetes-and-pancreas-size-does-it-matter
#13
EDITORIAL
Soroku Yagihashi
Since diabetes is defined by glucose dysmetabolism, pathological investigations on the pancreas in patients with diabetes have mostly been concentrated on the changes of Langerhans islets (endocrine pancreas). In fact, nearly complete loss of β-cells is usual in autoimmune-mediated or fulminant type 1 diabetes. Also in type 2 diabetes, β cell mass is reduced to approximately 50% in obese American patients, 35% in lean American patients, 40% in Korean patients, 40% in European patients and 30% in Japanese patients...
November 3, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27790855/determinants-of-hemoglobin-a1c-level-in-patients-with-type-2-diabetes-after-in-hospital-diabetes-education-a-study-based-on-continuous-glucose-monitoring
#14
Keiichi Torimoto, Yosuke Okada, Sachiko Sugino, Yoshiya Tanaka
AIMS/INTRODUCTION: We investigated the relationship between blood glucose profile at hospital discharge, evaluated by continuous glucose monitoring (CGM), and hemoglobin A1c (HbA1c) level at 12 weeks after discharge in patients with type 2 diabetes who received inpatient diabetes education. MATERIALS AND METHODS: This was a retrospective study. The subjects were 54 patients with type 2 diabetes who did not change their medication after discharge. The mean blood glucose (MBG), standard deviation (SD), coefficient of variation, mean postprandial glucose excursion, maximum blood glucose, minimum blood glucose, percentage of time with blood glucose at ≥180 mg/dL (Time at ≧180), percentage of time with blood glucose at ≥140 mg/dL, and percentage of time with blood glucose at <70 mg/dL were measured at admission and discharge using CGM...
October 27, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27762088/preventive-effect-of-ipragliflozin-on-nocturnal-hypoglycemia-in-patients-with-type-2-diabetes-treated-with-basal-bolus-insulin-therapy-an-open-label-single-center-parallel-randomized-control-study
#15
Fumitaka Okajima, Tomoko Nagamine, Yuko Nakamura, Naomi Hattori, Hitoshi Sugihara, Naoya Emoto
The efficacy of the administration of sodium-glucose co-transporter 2 inhibitor (SGLT2I) or the co-administration of SGLT2I and dipeptidyl peptidase-4 inhibitor (DPP-4I) to insulin therapy is not well known. Fifty-eight patients with type 2 diabetes, admitted for glycemic control, were randomized to basal-bolus insulin therapy (BBT) alone or BBT plus 50 mg ipragliflozin and/or 20 mg teneligliptin. Insulin doses were adjusted to maintain normal blood glucose levels. Plasma glucose profiles were estimated by continuous glucose monitoring (CGM) before discharge...
October 20, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27888582/nucleotide-substitutions-in-cd101-the-human-homolog-of-a-diabetes-susceptibility-gene-in-non-obese-diabetic-mouse-in-patients-with-type-1-diabetes
#16
Misako Okuno, Yoshihito Kasahara, Masafumi Onodera, Noriyuki Takubo, Michiko Okajima, Shigeru Suga, Nobuyuki Watanabe, Junichi Suzuki, Tadayuki Ayabe, Tatsuhiko Urakami, Tomoyuki Kawamura, Nobuyuki Kikuchi, Ichiro Yokota, Toru Kikuchi, Shin Amemiya, Kazuhiko Nakabayashi, Keiko Hayashi, Kenichiro Hata, Yoichi Matsubara, Tsutomu Ogata, Maki Fukami, Shigetaka Sugihara
AIMS/INTRODUCTION: Although genome-wide association studies have identified more than 50 susceptibility genes for type 1 diabetes, low-frequency risk variants could remain unrecognized. The present study aimed to identify novel type 1 diabetes susceptibility genes by newly established methods. MATERIALS AND METHODS: We carried out whole-exome sequencing and genome-wide copy-number analysis for a Japanese family consisting of two patients with type 1 diabetes and three unaffected relatives...
October 19, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27868359/linagliptin-improves-endothelial-function-in-patients-with-type-2-diabetes-a-randomized-study-of-linagliptin-effectiveness-on-endothelial-function
#17
Fumika Shigiyama, Naoki Kumashiro, Masahiko Miyagi, Ryo Iga, Yuka Kobayashi, Eiichiro Kanda, Hiroshi Uchino, Takahisa Hirose
AIMS/INTRODUCTION: The present multicenter, prospective, controlled, open and randomized three-arm parallel study was designed to compare the effects of linagliptin with those of metformin on endothelial function. MATERIALS AND METHODS: Type 2 diabetes patients treated with 750 mg of metformin (hemoglobin A1c ≥6.0% and <8.0%, n = 96) were randomized to continue metformin 750 mg/day (control group, n = 29), metformin at 1,500 mg/day (metformin group, n = 26) and metformin 750 mg/day supplemented with linagliptin 5 mg/day (linagliptin add-on group, n = 29) and treated for 16 weeks...
October 19, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27740719/sitagliptin-added-to-stable-insulin-therapy-with-or-without-metformin-in-chinese-patients-with-type-2-diabetes
#18
R Ravi Shankar, Yuqian Bao, Ping Han, Ji Hu, Jianhua Ma, Yongde Peng, Fan Wu, Lei Xu, Samuel S Engel, Weiping Jia
INTRODUCTION: We evaluated the tolerability and efficacy of the addition of sitagliptin in Chinese patients with type 2 diabetes mellitus (T2DM) on stable insulin therapy alone or in combination with metformin. MATERIALS AND METHODS: Four hundred sixty-seven patients with inadequate glycemic control on insulin (HbA1c ≥7.5% and ≤11%) were randomized 1:1 to receive sitagliptin 100 mg once-daily or matching placebo for 24 weeks. Randomization was stratified based on metformin use (on or not on metformin) and type of insulin (pre-mixed versus intermediate-/long-acting) at screening...
October 14, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27736036/analysis-of-the-association-between-glucose-profiles-and-beta-cell-function-for-diabetic-cardiovascular-autonomic-neuropathy-in-china
#19
Ping Fang, Jingcheng Dong, Fangfang Zeng, Zihui Tang
BACKGROUND: The purpose of this study was to investigate the severity of glucose profiles and beta cell function associated with diabetic cardiovascular autonomic neuropathy (DCAN) in a Chinese sample. METHOD: A community-based, cross-sectional study to analyze the risk factors of DCAN was conducted with 455 individuals recruited from a Chinese population. Glucose profile risk score (GRS) was calculated to identify the association between the severity of the glucose profiles and DCAN...
October 13, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27736033/four-year-sequential-nerve-conduction-changes-since-first-visit-in-japanese-patients-with-early-type-2-diabetes
#20
Mariko Kobori, Soroku Yagihashi, Norie Shiina, Nana Shiozawa, Akiko Haginoya, Misato Ojima, Satako Douguchi, Atsuko Tamasawa, Miyoko Saito, Masayuki Baba, Takeshi Osonoi
AIM/INTRODUCTION: Despite the commonest complication of diabetes, the pattern of clinical development of diabetic neuropathy is not well known. In this study, we retrospectively examined sequential changes in nerve conduction studies (NCS) for 4 years to characterize the way how neuropathic changes develop in patients with type 2 diabetes. MATERIALS AND METHOD: We randomly selected 158 patients with type 2 diabetes who newly visited our hospital and underwent serial 4 year NCS...
October 13, 2016: Journal of Diabetes Investigation
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