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Journal of Diabetes Investigation

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https://www.readbyqxmd.com/read/30328289/effect-of-oral-magnesium-sulfate-administration-on-lox-1-gene-expression-to-prevent-atherosclerosis-in-diabetic-rat-vessels
#1
Mina Fazlali, Fatemeh Kharazmi, Mitra Kamran, Kianoosh MaleKzadeh, Ardeshir Talebi, Fatemeh Khosravi, Nepton Soltani
INTRODUCTION: The purpose of this study was to investigate the possible effect of oral magnesium sulfate (MgSO4 ) in reduction of atherosclerosis plaques via inhibition of LOX-1 gene expression in diabetic vessels. MATERIAL AND METHODS: Fifty rats were divided into five groups including non-diabetic control (NDC); Mg-treated non-diabetic control (Mg -NDC); chronic diabetic (CD); Mg-treated chronic diabetic (Mg-CD); and insulin- treated chronic diabetic (Ins-CD)...
October 16, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30325586/in-silico-and-in-vitro-analyses-of-the-pathological-relevance-of-the-r258h-mutation-of-hepatocyte-nuclear-factor-4%C3%AE-identified-in-mody1
#2
Kenji Sugawara, Kazuhiro Nomura, Yuko Okada, Aki Sugano, Masaaki Matsumoto, Toru Takarada, Atsuko Takeuchi, Hiroyuki Awano, Yushi Hirota, Hisahide Nishio, Yutaka Takaoka, Wataru Ogawa
Mutations of the hepatocyte nuclear factor 4α (HNF4α) gene give rise to maturity-onset diabetes of the young type 1 (MODY1). Although many such mutations have been identified in affected individuals, part of these mutations have been characterized with regard to their pathological relevance. We here identified a missense mutation (c.773G>A, p.R258H) of HNF4A in a mother and daughter with early-onset diabetes and impaired insulin secretion. In silico simulation and in vitro luciferase reporter analyses indicated that the mutation impairs the stability of self-dimerization and the transactivation activity of HNF4α...
October 16, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30325576/a-retrospective-analysis-of-medical-costs-and-resource-utilization-for-severe-hypoglycemic-events-in-patient-with-type-2-diabetes-in-japan
#3
Yuika Ikeda, Takekazu Kubo, Eisei Oda, Machiko Abe, Shigeru Tokita
AIMS: This study aimed to describe hospital utilization and examine actual medical costs for severe hypoglycemic events in patients with type 2 diabetes mellitus in Japan. MATERIALS AND METHODS: Medical resource utilization associated with severe hypoglycemia was evaluated using a receipt database of acute-care hospitals in Japan. Patients with type 2 diabetes treated with antihyperglycemic agents were included. Severe hypoglycemic events were identified and divided into 2 groups: with or without hospitalization...
October 16, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30312020/metabolic-syndrome-increases-cardiovascular-risk-in-pre-diabetic-population-a-prospective-study-in-a-cohort-of-chinese-adults
#4
Zekai Chen, Shouling Wu, Jianhuan Huang, Jinhuan Yuan, Haojia Chen, Youren Chen
BACKGROUND: The prevalence of pre-diabetes has been epidemic globally and pre-diabetes is often accompanied with metabolic syndrome (MS). But the association between MS and cardiovascular (CV) risk among pre-diabetic individuals in China remains unknown. OBJECTIVE: This study aimed to identify the relationship of MS with CV risk in Chinese adults with prediabetes. METHODS: Altogether 19,464 participants with pre-diabetes were enrolled at baseline and were followed up prospectively...
October 12, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30307132/pkc-and-pka-involved-in-the-protection-of-rhglp-1-on-glomeruli-and-tubules-in-diabetic-rats
#5
Weiqin Yin, Yongwei Jiang, Shiqing Xu, Zai Wang, Liang Peng, Qing Fang, Tingting Deng, Wanni Zhao, Wenjian Zhang, Jinning Lou
AIMS/INTRODUCTION: Blockade or reversal the progression of diabetic nephropathy is a clinical challenge. To study whether the recombinant human glucagon-like peptide-1 have an effect on alleviate urinary protein and urinary albumin levels in diabetic rats or not. MATERIALS AND METHODS: STZ induced Diabetes Rats were treated with rhGLP-1, Insulin, and Saline. Using Immunostaining, H&E, EM and PAS staining to study the pathology of DN, and we performed qRT-PCR, Western blot and IHC to identify the differentially expressed proteins...
October 11, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30307128/accuracy-of-flush-glucose-monitoring-in-insulin-treated-patients-with-type-2-diabetes
#6
Tatsuya Sato, Hiroto Oshima, Kei Nakata, Yukishige Kimura, Toshiyuki Yano, Masato Furuhashi, Masaya Tannno, Takayuki Miki, Tetsuji Miura
This study evaluated the accuracy of interstitial glucose measurements by flush glucose monitoring (FGM) and continuous glucose monitoring (CGM). Five diabetic patients simultaneously underwent FGM (FreeStyle Libre Pro) and CGM (iPro™ 2) and their glucose levels were compared with venous blood and capillary blood glucose levels. The range of daily venous blood glucose levels (30 measurements) was 70-245 mg/dl with a median of 138 mg/dl. There were good correlations of glucose levels measured by FGM (r2 = 0...
October 11, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30307126/actual-condition-survey-regarding-mismatch-of-measurements-between-radioimmunoassay-and-enzyme-linked-immunosorbent-assay-tests-for-anti-glutamic-acid-decarboxylase-antibody-in-real-world-clinical-practice
#7
Yoichi Oikawa, Takuma Kondo, Akira Shimada, Yutaka Seino, Masafumi Kitaoka
Anti-glutamic acid decarboxylase antibody (GADA) is an important islet cell-associated autoantibody for the diagnosis of autoimmune type 1 diabetes mellitus (T1DM). In Japan, the GADA assay kit was recently changed from radioimmunoassay (RIA) to enzyme-linked immunosorbent assay (ELISA). Thereafter, a mismatched measurement between the two tests became apparent in clinical situations. This study aimed to clarify the actual extent of mismatch between the two measurements on a larger-scale real-world clinical practice...
October 11, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30306722/glycaemic-variability-assessed-by-continuous-glucose-monitoring-and-the-risk-of-diabetic-retinopathy-in-latent-autoimmune-diabetes-of-the-adult-and-type-2-diabetes
#8
Jingyi Lu, Xiaojing Ma, Lei Zhang, Yifei Mo, Lingwen Ying, Wei Lu, Wei Zhu, Yuqian Bao, Jian Zhou
OBJECTIVE: The relationship between glycaemic variability (GV) and diabetic complications has gained much interest and remains under debate. Moreover, the association of GV with diabetic complications has not been examined in latent autoimmune diabetes of the adult (LADA). Therefore, we evaluated the relationships among several metrics of GV with diabetic retinopathy (DR) in patients with LADA and type 2 diabetes (T2DM). METHODS: A total of 192 patients with LADA and 2927 patients with T2DM were enrolled...
October 10, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30300476/a-review-of-the-role-of-cigarette-smoking-in-the-diabetic-foot
#9
Nan Xia, Afsaneh Morteza, Fengyu Yang, Hong Cao, Aiping Wang
Diabetic foot ulceration has been a serious issue over the past decades in Asia, causing economic and social problems. Therefore, it is important to identify and reduce risk factors of diabetic foot. Cigarette smoking has been reported to be associated with diabetes and its macrovascular complications, but the relationship between smoking and diabetic foot ulcers is still unclear. In this review, we summarizes the effects of cigarette smoking on diabetic foot ulcers with respect to peripheral neuropathy, vascular alterations and wound healing...
October 9, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30300472/discordance-in-risk-factors-for-the-progression-of-diabetic-retinopathy-and-diabetic-nephropathy-in-patients-with-type-2-diabetes-mellitus
#10
Ki-Ho Song, Jee-Sun Jeong, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Hyun Baek, Seung-Hyun Ko, Yu-Bae Ahn
AIMS: We aimed to investigate whether there are differences in the risk factors or markers for the progression of diabetic retinopathy (DR) and diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We conducted a 3-year retrospective cohort study on 604 patients with T2DM mellitus. The outcomes were the progression of DR (worsening of the DR stage) and DN [an estimated glomerular filtration rate (eGFR) decline >12%] at the 3-year follow-up...
October 9, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30290079/contribution-of-pancreatic-alpha-cell-function-to-insulin-sensitivity-and-glycemic-variability-in-patients-with-type-1-diabetes
#11
Nobuyuki Takahashi, Daisuke Chujo, Hiroshi Kajio, Kohjiro Ueki
AIMS/INTRODUCTION: To evaluate the contribution of pancreatic alpha cell function to the dawn phenomenon, insulin sensitivity, hepatic glucose uptake (HGU), and glycemic variability in patients with type 1 diabetes. MATERIALS AND METHODS: In 40 patients with type 1 diabetes, arginine stimulation tests were performed, and the area under the curve of glucagon was measured using radioimmunoassays (AUCglc RIA ) and enzyme-linked immunosorbent assays (AUCglc ELISA )...
October 5, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30290074/restoration-of-myocardial-glucose-uptake-with-facilitated-glut-4-translocation-contributes-to-alleviation-of-diabetic-cardiomyopathy-in-rats-after-duodenal-jejunal-bypass
#12
Xin Huang, Dong Wu, Yugang Cheng, Xiang Zhang, Teng Liu, Qiaoran Liu, Pingtian Xia, Guangyong Zhang, Sanyuan Hu, Shaozhuang Liu
AIMS/INTRODUCTION: Duodenal-jejunal bypass (DJB) surgery has been reported to relieve diabetic cardiomyopathy (DCM) effectively. However, the specific mechanisms remain largely unknown. This study was designed to determine the alterations of myocardial glucose uptake (MGU) after DJB and their effects on DCM. MATERIALS AND METHODS: DJB and Sham surgeries were performed in diabetic rats induced by high fat diet and low dose of streptozotocin, with chow-diet fed rats as control...
October 5, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30290070/human-glomerular-transcriptome-of-diabetic-kidneys-can-podocyte-cytoskeleton-be-therapeutic-target
#13
Yoshiro Maezawa, Koutaro Yokote
Diabetic nephropathy is the leading cause of end stage renal failure in Japan. Clarification of its detailed pathogenesis and development of therapeutic methods are urgent issues. In this article in the Journal of the American Society of Nephrology, Pan et al.[1] showed a usefulness of weighted gene co-expression network analysis (WGCNA) and identified a potentially important candidate molecules that regulate diabetic nephropathy. This article is protected by copyright. All rights reserved.
October 5, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30290069/fat-cell-lipolysis-and-future-weight-gain
#14
Hitoshi Nishizawa, Iichiro Shimomura
Obesity and type 2 diabetes mellitus has been increasing worldwide and are considered to be related to physical inactivity and dysregulated eating behavior. Although environmental factors are important in the progression of obesity, the contribution of adipose tissue dysfunction and related genetic factors have been less clear. This article is protected by copyright. All rights reserved.
October 5, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30290067/adolescent-underweight-is-independently-associated-with-adult-onset-diabetes-among-women-the-japan-nurses-health-study
#15
Kota Katanoda, Mitsuhiko Noda, Atsushi Goto, Hideki Mizunuma, Jung Su Lee, Kunihiko Hayashi
AIMS: To examine the association between adult-onset diabetes and life-course body weight changes. METHODS: In a cross-sectional study, 17,398 Japanese female nurses aged ≥30 completed a self-administered questionnaire in 2001-2007. Body weight indices were calculated for three life stages: birth weight (adjusted for gestational age), body mass index (BMI) at age 18, and current BMI. Odds ratios for being diagnosed with adult-onset diabetes were calculated according to the combined body weight categories of two life stages: at birth and age 18; and at age 18 and the survey (current)...
October 5, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30290061/early-administration-of-dapagliflozin-preserves-pancreatic-beta-cell-mass-through-a-legacy-effect-in-type-2-diabetic-mice
#16
Ayumi Kanno, Shun-Ichiro Asahara, Mao Kawamura, Ayuko Furubayashi, Shoko Tsuchiya, Emi Suzuki, Tomoko Takai, Maki Koyanagi-Kimura, Tomokazu Matsuda, Yuko Okada, Wataru Ogawa, Yoshiaki Kido
AIMS/INTRODUCTION: The preservation of pancreatic β-cell mass is an essential factor in the onset and development of type 2 diabetes mellitus. Recently, sodium-glucose co-transporter 2 inhibitors have been launched as anti-hyperglycemic agents, and their organ-protective effects are attracting attention. They are also reported to have favorable effects on the preservation of pancreatic β-cell mass, but the appropriate timing for the administration of sodium-glucose co-transporter 2 inhibitors is obscure...
October 5, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30267620/alendronate-improves-fasting-plasma-glucose-and-insulin-sensitivity-and-decreases-insulin-resistance-in-prediabetic-osteopenic-postmenopausal-women-a-randomized-triple-blind-clinical-trial
#17
Maryam Karimi Fard, Ashraf Aminorroaya, Ali Kachuei, Mohammad Reza Salamat, Moluk Hadi Alijanvand, Sima Aminorroaya Yamini, Mansoor Karimifar, Awat Feizi, Massoud Amini
AIMS: Postmenopausal women receive bisphosphonates for osteoporosis treatment. The effect of these medications on developing diabetes mellitus (DM) in prediabetic patients is yet to be investigated. We aimed to determine the effect of alendronate on plasma glucose, insulin indices of postmenopausal women with prediabetes and osteopenia. METHODS: This triple-blind randomized controlled clinical trial included 60 postmenopausal women, aged 45-60 years. All patients were vitamin D sufficient...
September 29, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30264429/prevalence-of-diabetes-among-homeless-men-in-nagoya-japan-a-survey-study
#18
Mayumi Yamamoto, Takahiro Watanabe, Ryosuke Uehara, Ryo Horita, Tadahiro Sado, Akihiro Nishio
AIMS/INTRODUCTION: The diabetes status of homeless people has not been elucidated because of the limited access to this population. We conducted a survey of the prevalence of diabetes and pre-diabetes among homeless men in Nagoya, Japan, and assessed the associations between diabetes prevalence and sociodemographic characteristics. METHODS: Interviews relating to subjects' sociodemographic background, mental illness, and cognitive ability and blood sampling were conducted in 106 homeless men (average age 54...
September 28, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30251333/12-s-hete-impairs-vascular-endothelial-permeability-by-altering-adherens-junction-phosphorylation-levels-and-affecting-the-binding-and-dissociation-of-its-components-in-high-glucose-induced-vascular-injury
#19
Xiaofang Wang, Lu Gao, Lili Xiao, Lulu Yang, Wenshu Li, Gangqiong Liu, Linlin Chen, Jinying Zhang
INTRODUCTION: Diabetes is an important risk factor for atherosclerotic disease. The initiating factor of atherosclerosis is local endothelial cell injury. The arachidonic acid metabolite, 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), may be involved in this process. In recent years, some reports discussed the effect of 12(S)-HETE on vascular endothelial cell function. In this study, we investigated the effect of 12(S)-HETE on vascular endothelial cell function in high-glucose conditions and the mechanisms involved...
September 24, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30248247/gip-signaling-in-adipose-tissue
#20
EDITORIAL
Shunsuke Yamane, Norio Harada
Obesity has been recognized as a worldwide problem, especially for developing insulin resistance and increasing the risk of type 2 diabetes. The increased adipose tissue associated with obesity secretes various kinds of cytokines, adipokines, and lipokines, and triggers systemic inflammatory response, resulting in the disturbance of metabolic homeostasis. This article is protected by copyright. All rights reserved.
September 24, 2018: Journal of Diabetes Investigation
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