journal
MENU ▼
Read by QxMD icon Read
search

Journal of Diabetes Investigation

journal
https://www.readbyqxmd.com/read/28804981/lipopolysaccharide-inhibits-hepatic-gluconeogenesis-in-rats-the-role-of-immune-cells
#1
Hiroshi Tanaka, Yoshikazu Nishikawa, Toru Fukushima, Ataru Taniguchi, Yoshihito Fujita, Kinsuke Tsuda, Nobuya Inagaki, Masaya Hosokawa
AIMS/INTRODUCTION: Bacterial septicemia has diverse clinical symptoms including severe hypoglycemia. However, sepsis-induced hypoglycemia has not yet been examined in detail. The aim of the present study is to investigate the mechanisms underlying hypoglycemia in sepsis. MATERIALS AND METHODS: We induced endotoxin shock in rats using lipopolysaccharide (LPS). After an intraperitoneal injection of LPS, we measured gluconeogenesis using the pyruvate tolerance test (PTT)...
August 14, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28796932/factors-associated-with-greater-benefit-of-a-national-reimbursement-policy-for-blood-glucose-test-strips-in-adult-patients-with-type-1-diabetes-a-prospective-cohort-study
#2
Sang-Man Jin, Jong Ha Baek, Sunghwan Suh, Chang Hee Jung, Woo Je Lee, Cheol-Young Park, Hae Kyung Yang, Jae Hyoung Cho, Byung-Wan Lee, Jae Hyeon Kim
AIMS/INTRODUCTION: We aimed to identify factors independently associated with greater benefit of a national reimbursement policy for blood glucose test strips in adult patients with type 1 diabetes (T1DM), in terms of glycemic control and rate of severe hypoglycemia. MATERIALS AND METHODS: This was a prospective cohort study of 466 adult patients with T1DM from five tertiary referral hospitals who registered for a national reimbursement program for blood glucose strips and were then followed-up for 12 months...
August 10, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28796422/insulin-producing-cells-derived-from-induced-pluripotent-stem-cells-of-patients-with-fulminant-type-1-diabetes-vulnerability-to-cytokine-insults-and-increased-expression-of-apoptosis-related-genes
#3
Yoshiya Hosokawa, Taro Toyoda, Kenji Fukui, Megu Yamaguchi Baden, Michinori Funato, Yasushi Kondo, Tomomi Sudo, Hiromi Iwahashi, Marina Kishida, Chihiro Okada, Akira Watanabe, Isao Asaka, Kenji Osafune, Akihisa Imagawa, Iichiro Shimomura
AIMS/INTRODUCTION: This study was performed to generate induced pluripotent stem cells (iPSCs) from patients with fulminant type 1 diabetes (FT1D) and evaluate the cytokine-induced apoptotic reactions of beta-like insulin-producing cells differentiated from the iPSCs. MATERIALS AND METHODS: iPSCs were generated from fibroblasts of patients with FT1D by inducing six reprogramming factors. Insulin-producing cells were differentiated from the iPSCs in vitro. The proportion of cleaved caspase-3-positive or TUNEL-positive cells among INSULIN (INS)-positive cells derived from FT1D-iPSC and control human-iPSC lines was evaluated under treatment with tumor necrosis factor-alpha, interleuin-1-beta, and interferon-gamma...
August 10, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28786564/epigenetic-dysregulation-in-pancreatic-islets-and-pathogenesis-of-type-2-diabetes
#4
Norihide Yokoi
Most of type 2 diabetes is thought to be the result of interaction between genetic and environmental factors. However, the genetic components discovered to date can explain only a small proportion of the observed heritability. The "missing heritability" may be accounted for by rare variants, gene-environment interactions, and epigenetics. This article is protected by copyright. All rights reserved.
August 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28786562/unfolding-link-between-diabetes-and-cancer
#5
Hiroshi Noto
A growing body of evidence has shown that type 2 diabetes is associated with increased risks of total cancer death and total cancer incidence including cancers of the liver, endometrium, pancreas, kidney, colorectum, bladder, and breast (1) . Of interest, the risk of prostate cancer is significantly decreased. Although the majority of the studies on this topic have been conducted in Western countries, those risk ratios (RRs) of all-cancer mortality and incidence across all cancer types are reportedly even higher in Asians (Table 1) (2) ...
August 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28779533/effect-of-real-time-continuous-glucose-monitoring-on-hypoglycemia-in-adult-type-1-diabetes
#6
Weiping Jia
Hypoglycemia is one of the major challenges in diabetes management for most patients, especially among those with type 1 diabetes. Clinical studies have shown that hypoglycemia can lead to cognitive dysfunction and behavioral impairment. Continuous glucose monitoring (CGM) can provide continuous, comprehensive, and reliable blood glucose information and facilitate the early detection and evaluation of hypoglycemia, thereby providing guidance for the treatment for hypoglycemia. In this article by Van Beers et al...
August 5, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28779528/the-metabolomics-window-into-diabetic-complications
#7
REVIEW
Tao Wu, Shuxuan Qiao, Chenze Shi, Shuya Wang, Guang Ji
Diabetes has become a major global health problem. The elucidation of characteristic metabolic alterations during the diabetic progression is critical for better understanding its pathogenesis and identifying potential biomarkers and drug targets. Metabolomics is a promising tool to reveal the metabolic changes and the underlying mechanism involved in the pathogenesis of diabetic complications. The present review provides an update on the application of metabolomics in diabetic complications, including diabetic coronary artery disease, diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy, and this review provides notes on the prevention and prediction of diabetic complications...
August 5, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28767190/insulin-degludec-in-the-first-trimester-of-pregnancy-report-of-two-cases
#8
Agostino Milluzzo, Andrea Tumminia, Nunzio M Scalisi, Lucia Frittitta, Riccardo Vigneri, Laura Sciacca
Insulin degludec is an extra-long-acting insulin analog that allows for enhanced efficacy and flexibility in the injection time. However, it is not approved for use during pregnancy. We report the pregnancy outcome and newborn conditions in two type 1 diabetic women who continued pre-conception degludec treatment during embryogenesis. No pregnancy complication or congenital neonatal malformation was observed. Both babies presented with hypoglycemia and required neonatal intensive care unit admission. Degludec treatment did not cause adverse effects in the mothers or malformations in the newborns...
August 2, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28766917/accelerated-oligosaccharide-absorption-and-altered-serum-metabolites-during-oral-glucose-tolerance-test-in-young-japanese-with-impaired-glucose-tolerance
#9
Takashi Miki, Eun Young Lee, Akifumi Eguchi, Kenichi Sakurai, Yuji Sawabe, Tomohiko Yoshida, Keiko Saito, Hidetaka Yokoh, Ko Ishikawa, Koutaro Yokote, Takeshi Kuzuya, Eishi Miki, Chisato Mori, Fumio Nomura
AIMS/INTRODUCTION: Impaired glucose tolerance (IGT) is a subtype of prediabetes, a condition having high risk for development to diabetes mellitus (DM), but its pathophysiology is not fully understood. In the present study, we examined metabolic changes in IGT by using two types [D-glucose (Glc) and partial hydrolysate of starch (PHS)] of oral glucose tolerance tests (OGTT), with emphasis on serum incretins and metabolites. MATERIALS AND METHODS: We performed the 2 types of OGTT (Glc/OGTT and PHS/OGTT) in 99 young Japanese individuals who had tested either positive (GU(+) ) (n=48) or negative (GU(-) ) (n=51) for glycosuria...
August 2, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28766895/pancreatic-fat-content-assessed-by-1-h-magnetic-resonance-spectroscopy-is-correlated-with-insulin-resistance-but-not-with-insulin-secretion-in-japanese-subjects-with-normal-glucose-tolerance
#10
Hisako Komada, Kazuhiko Sakaguchi, Yushi Hirota, Anna Sou, Tomoaki Nakamura, Katsusuke Kyotani, Hideaki Kawamitsu, Kazuro Sugimura, Yoko Okuno, Wataru Ogawa
AIMS/INTRODUCTION: Whereas some clinical studies have shown that excessive fat accumulation in the pancreas is associated with impairment of insulin secretion, others have not found such an association. (1) H-Magnetic resonance spectroscopy (MRS) allows quantitative fat analysis in various tissues including the pancreas. The pathological relevance of pancreatic fat content (PFC) in Japanese individuals remains unclear, however. MATERIALS AND METHODS: We analyzed PFC in 30 Japanese subjects with normal glucose tolerance by (1) H-MRS and then investigated the relations between PFC and indexes of insulin secretion and insulin sensitivity-resistance determined by an oral glucose tolerance test (OGTT)...
August 2, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28752566/impaired-insulin-clearance-as-a-cause-rather-than-a-consequence-of-insulin-resistance
#11
EDITORIAL
Hirotaka Watada, Yoshifumi Tamura
Impaired insulin sensitivity and reduced β cell function have been regarded as the two major physiological defects in type 2 diabetes mellitus. It is generally accepted that the initial defect in this disease is insulin resistance, which is typically elicited by overeating and decreased physical activity, both of which are tightly linked with obesity. β cells then compensate for insulin resistance by enhancing insulin secretion. This article is protected by copyright. All rights reserved.
July 28, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28746743/the-incretin-concept-revised-the-origin-of-glp-1-s-insulinotropic-function-the-gut-the-islets-or-both
#12
Daisuke Yabe, Yusuke Seino, Yutaka Seino
Incretins comprise a pair of gut hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), which are secreted in response to food ingestion and enhance glucose-dependent insulin secretion (GIIS) from pancreatic β-cells. Immediately after secretion, GLP-1 is degraded by dipeptidyl peptidase-4 (DPP-4) more rapidly than GIP, and circulating levels of biologically intact GLP-1 are substantially lower than those of biologically intact GIP. Therefore, there has been a debate on how the gut-derived GLP-1 exerts insulinotropic actions...
July 26, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28741806/serum-%C3%AE-glutamyltransferase-level-and-metabolic-syndrome-in-children-and-adolescents-korean-national-health-and-nutrition-examination-survey
#13
Jae-Min Park, Jee-Yon Lee, Duk-Chul Lee, Yong-Jae Lee
AIMS/INTRODUCTION: Serum γ-glutamyltransferase (GGT) is positively related to cardiometabolic diseases such as type 2 diabetes mellitus, hypertension, and metabolic syndrome (MetS) in adult populations. Our aim was to investigate whether serum GGT is independently associated with MetS and its components in a nationally representative sample of South Korean children and adolescents. MATERIALS AND METHODS: The study included data from 1,618 participants (867 boys, 751 girls) aged 10-18 years from the 2010-2011 Korean National Health and Nutrition Examination Survey...
July 25, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28734095/increased-trend-in-the-incidence-of-diabetes-among-youths-in-the-united-states-2002-2012
#14
Tatsuhiko Urakami
The SEARCH for Diabetes in Youth Study (SEARCH Study) reported on estimated trends in the incidence of type 1 and type 2 diabetes (T1D and T2D) among youths at five centers in the United States during 2002-2012 (1) . The SEARCH Study previously demonstrated increases in the prevalence of both types of diabetes during 2001-2009 (2) . After calculating the annual incidence rates for the period from 2002 to 2012, the incidence trends were analyzed by generalized autoregressive moving-average models with 2-year moving averages...
July 22, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28731289/current-status-of-achieving-blood-pressure-target-and-its-clinical-correlates-in-japanese-type-2-diabetes
#15
Hiroki Yokoyama, Shin-Ichi Araki, Koichi Kawai, Koichi Hirao, Yoshio Kurihara, Hiroaki Seino, Hiroshi Takamura, Hidekatsu Sugimoto, Akira Okada, Hiroshi Maegawa
AIMS/INTRODUCTION: To investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drug classes as of 2013, and to explore the clinical correlates with achievement of target blood pressure in a large-scale cohort of Japanese subjects with type 2 diabetes. MATERIALS AND METHODS: A nationwide survey was conducted including 12,811 subjects with type 2 diabetes. Subjects were divided by achieved blood pressure, <130/80 or 140/90 mmHg, and the number of drug classes taken...
July 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28686352/the-ratio-of-visceral-to-subcutaneous-fat-area-predicts-cardiovascular-events-in-patients-with-type-2-diabetes
#16
Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
AIMS/INTRODUCTION: To investigate whether the ratio of visceral fat area (VFA) to subcutaneous fat area (SFA) (V/S ratio) could be predictive of cardiovascular disease (CVD) as compared with VFA or SFA in patients with diabetes. MATERIALS AND METHODS: 682 patients with type 2 diabetes (mean age 64 ± 13 years; 41% female) were enrolled. VFA (cm(2) ) and SFA (cm(2) ) were assessed by dual bioelectrical impedance analyzer (BIA). The patients were divided into four groups according to the quartiles of V/S ratio...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28686322/characteristics-of-frequent-emergency-department-users-with-type-2-diabetes-mellitus-in-korea
#17
Morena Ustulin, Junghoon Woo, Jeong-Taek Woo, Sang Youl Rhee
AIMS/INTRODUCTION: Frequent emergency department (ED) visitors are medically vulnerable subjects. We identified the characteristics of "frequent ED users" among Korean patients with type 2 diabetes mellitus (DM). MATERIALS AND METHODS: We used the Health Insurance Review and Assessment Service National Patient Sample HIRA-(NPS), which is a nationally representative sample. Subjects (n = 109,412) with type 2 DM as a primary or secondary diagnosis at one of their visits were included...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28685995/meta-analysis-and-critical-review-on-the-efficacy-and-safety-of-alpha-glucosidase-inhibitors-in-asian-and-non-asian-populations
#18
Xueying Gao, Xiaoling Cai, Wenjia Yang, Yifei Chen, Xueyao Han, Linong Ji
AIMS: To evaluate the efficacy and safety of alpha glucosidase inhibitors (AGI) in Asian and non-Asian type 2 diabetic patients. MATERIALS AND METHODS: Studies were identified through a literature search of MEDLINE, EMBASE, and other databases until December 2016. All statistical analyses were conducted in Review Manager statistical software by computing the weighted mean difference (WMD) or odds ratio (OR) and 95% confidence interval (CI). RESULTS: A total of 67 studies were included...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28685957/the-characteristics-of-carotid-atherosclerosis-in-elderly-patients-with-type-2-diabetes-at-different-disease-course-and-the-intervention-by-statins-in-the-very-elderly-patients
#19
Wenjun Chen, Tao Tian, Shiming Wang, Yan Xue, Zongqin Sun, Shuli Wang
INTRODUCTION: Chronic complications of diabetes have become the leading cause of death in elderly patients with diabetes. Carotid atherosclerosis, one of the major complications was evaluated and the effect of atorvastatin on carotid atherosclerosis in very elderly patients with type 2 diabetes (T2D) were observed. MATERIAL AND METHODS: Patients were divided into 3 groups: 1) disease course < 5 years; 2) disease course = 5-10 years; 3) disease course > 10 years, and carotid atherosclerosis were evaluated...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28667795/dietary-intake-habits-and-prevalence-of-nocturia-in-japanese-patients-with-type-2-diabetes-mellitus
#20
Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Hisaka Minami, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake
AIMS/INTRODUCTION: No reports have been published on the association between dietary intake habits and nocturia in the diabetes population. We therefore estimate this issue among Japanese patients with diabetes mellitus. MATERIALS AND METHODS: Study subjects in the present study were 785 Japanese patients with type 2 diabetes mellitus. Self-administrated questionnaires were used to assess each type of dietary intake habits. Vegetable intake habit was assessed by the following question: Do you have vegetables or seaweed every day?" We used the following two outcomes: 1) nocturia: ≥ 2 voids per night and 2) severe nocturia: ≥ 3 voids per night...
July 1, 2017: Journal of Diabetes Investigation
journal
journal
42764
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"