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Journal of Diabetes Investigation

Fumitaka Okajima, Tomoko Nagamine, Yuko Nakamura, Naomi Hattori, Hitoshi Sugihara, Naoya Emoto
The efficacy of the administration of sodium-glucose co-transporter 2 inhibitor (SGLT2I) or the co-administration of SGLT2I and dipeptidyl peptidase-4 inhibitor (DPP-4I) to insulin therapy is not well known. Fifty-eight patients with type 2 diabetes, admitted for glycemic control, were randomized to basal-bolus insulin therapy (BBT) alone or BBT plus 50 mg ipragliflozin and/or 20 mg teneligliptin. Insulin doses were adjusted to maintain normal blood glucose levels. Plasma glucose profiles were estimated by continuous glucose monitoring (CGM) before discharge...
October 20, 2016: Journal of Diabetes Investigation
R Ravi Shankar, Yuqian Bao, Ping Han, Ji Hu, Jianhua Ma, Yongde Peng, Fan Wu, Lei Xu, Samuel S Engel, Weiping Jia
INTRODUCTION: We evaluated the tolerability and efficacy of the addition of sitagliptin in Chinese patients with type 2 diabetes mellitus (T2DM) on stable insulin therapy alone or in combination with metformin. MATERIALS AND METHODS: Four hundred sixty-seven patients with inadequate glycemic control on insulin (HbA1c ≥7.5% and ≤11%) were randomized 1:1 to receive sitagliptin 100 mg once-daily or matching placebo for 24 weeks. Randomization was stratified based on metformin use (on or not on metformin) and type of insulin (pre-mixed versus intermediate-/long-acting) at screening...
October 14, 2016: Journal of Diabetes Investigation
Ping Fang, Jingcheng Dong, Fangfang Zeng, Zihui Tang
BACKGROUND: The purpose of this study was to investigate the severity of glucose profiles and beta cell function associated with diabetic cardiovascular autonomic neuropathy (DCAN) in a Chinese sample. METHOD: A community-based, cross-sectional study to analyze the risk factors of DCAN was conducted with 455 individuals recruited from a Chinese population. Glucose profile risk score (GRS) was calculated to identify the association between the severity of the glucose profiles and DCAN...
October 13, 2016: Journal of Diabetes Investigation
Mariko Kobori, Soroku Yagihashi, Norie Shiina, Nana Shiozawa, Akiko Haginoya, Misato Ojima, Satako Douguchi, Atsuko Tamasawa, Miyoko Saito, Masayuki Baba, Takeshi Osonoi
AIM/INTRODUCTION: Despite the commonest complication of diabetes, the pattern of clinical development of diabetic neuropathy is not well known. In this study, we retrospectively examined sequential changes in nerve conduction studies (NCS) for 4 years to characterize the way how neuropathic changes develop in patients with type 2 diabetes. MATERIALS AND METHOD: We randomly selected 158 patients with type 2 diabetes who newly visited our hospital and underwent serial 4 year NCS...
October 13, 2016: Journal of Diabetes Investigation
Hiroyasu Mori, Akio Kuroda, Michiko Araki, Reiko Suzuki, Satoshi Taniguchi, Motoyuki Tamaki, Yuko Akehi, Munehide Matsuhisa
Accumulation of advanced glycation end products (AGEs) is thought to contribute to muscle weakness in a diabetic animal model. Skin autofluorescence (AF) is a proposed marker for accumulation of AGEs in the skin. We aimed to investigate the relationship between AGEs accumulation, sarcopenia, and muscle function of Japanese patients with type 1 diabetes. Thirty-six patients with type 1 diabetes participated in this cross-sectional study. Sarcopenia parameters (skeletal muscle mass index (SMI) and knee extension strength) were compared with subcutaneous AGEs accumulation using skin AF...
October 11, 2016: Journal of Diabetes Investigation
Sin Gon Kim, Nam Hoon Kim, Bon Jeong Ku, Ho Sang Shon, Doo Man Kim, Tae Sun Park, Yong-Seong Kim, In Joo Kim, Dong Seop Choi
AIMS/INTRODUCTION: To assess the time to initiation of insulin therapy and concurrently investigate both patient- and physician-related factors associated with delaying insulin therapy in Korean patients with type 2 diabetes (T2D) uncontrolled on oral hypoglycemic agents (OHAs). MATERIALS AND METHODS: This prospective, observational disease registry study was conducted across 69 centers in Korea. T2D patients who had received two or more OHAs within the last 5 years, had a glycated hemoglobin (HbA1c) ≥8% in the last 6 months, and had not received insulin were included...
October 6, 2016: Journal of Diabetes Investigation
Siting Chen, Xuyang Zuo, Yuan Li, Tian Jiang, Nan Zhang, Fang Dai, Qiu Zhang
AIM: The aim of this research is to study the ghrelin level, executive function, and their possible association in patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: 370 people were recruited between March 2015 and March 2016 in this study. Among them, 212 subjects were patients with T2DM and 158 subjects were included as control group. Their blood sample was analyzed for the level of ghrelin and other clinical indexes. Cognitive function was measured by Montreal Cognitive Assessment (MoCA) and executive function was evaluated by Wisconsin Card Sorting Test (WCST)...
September 30, 2016: Journal of Diabetes Investigation
Hoang Van Tong, Nguyen Kim Luu, Ho Anh Son, Nguyen Van Hoan, Trinh Thanh Hung, Thirumalaisamy P Velavan, Nguyen Linh Toan
AIM: Adipose tissue-derived hormones are associated with metabolic disorders including T2DM. This study investigated the levels of adiponectin and pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), Interleukin-1 beta (IL-1β), Interleukin-10 (IL-10) in Vietnamese patients with type 2 diabetes mellitus (T2DM) and their correlations with clinical parameters of overweight and T2DM. MATERIALS AND METHODS: Based on body mass index (BMI), 73 patients with T2DM were divided either as overweight or non-overweight subjects...
September 29, 2016: Journal of Diabetes Investigation
Daisuke Yabe, Yutaka Seino
Incretin-based dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists are newer choices of antidiabetic medications that are now most widely used worldwide. Preclinical study results suggest that the two drugs potentially exert benefits to prevent onsets and/or progressions of diabetes-related complications, such as myocardial infarctions and strokes. Outcomes of five clinical trials to evaluate the cardiovascular (CV) safety of dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonist have been recently reported...
September 9, 2016: Journal of Diabetes Investigation
Fei Mao, Siying Liu, Xiaona Qiao, Hangping Zheng, Qian Xiong, Jie Wen, Lianyong Liu, Mingming Tang, Shuo Zhang, Zhaoyun Zhang, Hongying Ye, Bin Lu, Yiming Li
AIMS/INTRODUCTION: The aim of the present study was to use the sudomotor function test, Sudoscan, as a screening method for the evaluation of asymptomatic diabetic distal symmetric polyneuropathy in Chinese type 2 diabetes patients. As a result, more attention could be paid to those asymptomatic patients who could be easily neglected and underdiagnosed in everyday clinic. MATERIALS AND METHODS: A total of 394 Chinese type 2 diabetes patients were enrolled and tested for symptoms and clinical signs of neuropathy using the Neurological Symptom Score, Neuropathy Disability Score, and vibration perception threshold...
September 8, 2016: Journal of Diabetes Investigation
Fang He, Hua He, Wenqi Liu, Junyu Lin, Bingjun Chen, Yucong Lin, Yitao Zhao, Wen Tao, Xuefeng Xia
AIMS/INTRODUCTION: A large neck circumference might be an indicator of metabolic syndrome and its components, and for certain patients is more practical as an index than waist circumference. The demarcation value for neck circumference that suggests metabolic syndrome appears to vary by ethnic group. Gestational diabetes mellitus is considered a component of metabolic syndrome in pregnant women. We investigated whether neck circumference in Han Chinese women is associated with gestational diabetes mellitus in early pregnancy, and determined a predictive demarcation value...
September 2, 2016: Journal of Diabetes Investigation
Akihiro Kikuchi, Toshinari Takamura
An elevation of fatty acid delivery amplifies the TCA cycle flux with a rise in anaplerosis/cataplerosis, leading to a proportional rise in oxidative stress and inflammation in liver.
August 31, 2016: Journal of Diabetes Investigation
Kyeong Seon Park, SooHeon Kwak, Young Min Cho, Kyong Soo Park, Hak C Jang, Seong Yeon Kim, Hye Seung Jung
AIMS/INTRODUCTION: Dipeptidyl peptidase-4 inhibitors might have pleiotropic protective effects on cardiovascular disease (CVD), in contrast to sulfonylureas. Therefore, we compared various CVD risk factors between vildagliptin and glimepiride. MATERIALS AND METHODS: We carried out a randomized, prospective and crossover trial. A total of 16 patients with type 2 diabetes whose glycated hemoglobin was >7% were randomized to add vildagliptin or glimepiride. After 12-week treatment, each drug was replaced with the other for another 12 weeks...
August 30, 2016: Journal of Diabetes Investigation
Takuya Yamamoto, Shota Moyama, Hideki Yano
AIMS/INTRODUCTION: We devised a new system called the "Educational Guidance" (E-Guide) for nutritional education based on self-efficacy. The present study aimed to examine the effects of E-Guide use on glycemic control among patients with type 2 diabetes (T2DM). MATERIALS AND METHODS: We conducted an interventional and observational study that included 74 patients with T2DM. The extent of glycemic control in the 39 patients who received guidance via the E-Guide (E-Guide group) was compared with that of 35 patients who received conventional nutritional guidance (control group)...
August 27, 2016: Journal of Diabetes Investigation
Yukiko Onishi, Kenichi Yamada, Jeppe Zacho, Jan Ekelund, Yasuhiko Iwamoto
AIMS/INTRODUCTION: Insulin degludec/insulin aspart (IDegAsp) is a soluble combination of insulin degludec (70%) and insulin aspart (30%). The present exploratory trial investigated the safety of switching unit-to-unit from twice-daily basal or pre-mix insulin to twice-daily IDegAsp in Japanese patients with type 2 diabetes. MATERIALS AND METHODS: In this 6-week, open-label, parallel-group, controlled trial, 66 participants were randomized (1:1) to receive either IDegAsp or biphasic insulin aspart 30 (BIAsp 30) twice daily at the same total daily dose as pre-trial insulin...
August 25, 2016: Journal of Diabetes Investigation
Angela Shin-Yu Lien, Yi-Der Jiang
The International Diabetes Federation estimated approximately 415 million people with diabetes in 2015 worldwide, and this number is expected to increase to 642 million by 2040 (1). Almost half of the people with diabetes remain undiagnosed and are from developing countries. Early interventions such as screening or lifestyle regulation for diabetes at the asymptomatic stage are effective preventive strategies for diabetes and its complications. However, the incidence and prevalence rates of diabetes are increasing worldwide, particularly in minority groups...
August 23, 2016: Journal of Diabetes Investigation
Makito Tanabe, Ryoko Motonaga, Yuichi Terawaki, Takashi Nomiyama, Toshihiko Yanase
INTRODUCTION: In treatment algorithms of type-2 diabetes mellitus (T2DM) in Western countries, biguanides are recommended as first-line agents. In Japan, various oral hypoglycemic agents (OHAs) are available, but prescription patterns are unclear. MATERIALS AND METHODS: Data of 7,108 and 2,655 T2DM patients in study-1 and -2, respectively, were extracted from the MDV database (2008-2013). Cardiovascular disease (CVD) history was not considered in study-1, but was in study-2...
August 23, 2016: Journal of Diabetes Investigation
Mengjuan Xue, Chaoyang Lv, Xianying Chen, Jing Liang, Chenhe Zhao, Yao Zhang, Xiaowu Huang, Qiman Sun, Ting Wang, Jian Gao, Jian Zhou, Mingxiang Yu, Jia Fan, Xin Gao
AIM: To investigate whether donor liver steatosis increases the incidence of new-onset diabetes after transplantation (NODAT) in liver transplant recipients. METHODS: We retrospectively analyzed liver transplant recipients at our hospital from April 2001 to December 2014. The final analysis involved 763 patients. The cumulative incidence of NODAT at 1, 3, 5, and 10 years after liver transplantation was investigated. Further, according to the findings of donor liver biopsy before transplantation, patients were divided into steatotic and non-steatotic donor liver groups, and NODAT incidence was compared between these groups...
August 10, 2016: Journal of Diabetes Investigation
Jun Shirakawa, Yasuo Terauchi
The concern over global epidemics of diabetes and obesity has risen. Obesity is a conspicuous risk factor for the development of type 2 diabetes, and with the global obesity rates rising, diabetes can be considered as a global public health problem. Aging of the society, lifestyle changes, and epigenetic modifications have all caused a rapid increase in diabetes prevalence especially in Asian countries. One explanation for the large impact of lifestyle changes on diabetes prevalence is the change in dietary habits...
August 1, 2016: Journal of Diabetes Investigation
Nobuyuki Takahashi, Tetsuro Tsujimoto, Kaori Inoue, Miyako Kishimoto, Hiroshi Kajio
Insulin degludec improved glycemic control in a type 1 diabetes patient undergoing hemodialysis.
September 2016: Journal of Diabetes Investigation
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