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Journal of Diabetes Investigation

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https://www.readbyqxmd.com/read/28429860/safety-tolerability-and-efficacy-of-lixisenatide-in-combination-with-oral-antidiabetic-treatment-in-japanese-patients-with-type-2-diabetes-an-open-label-multicenter-study
#1
Yutaka Seino, Aleksandra Stjepanovic, Akane Takami, Hiroki Takagi
AIM/INTRODUCTION: To assess overall safety and efficacy of lixisenatide in combination with background oral antidiabetic drug treatment in Japanese patients with type 2 diabetes, as required by Japanese guidelines. MATERIALS AND METHODS: A Phase 3, multicenter, uncontrolled, open-label, four-arm, parallel-group study in Japanese outpatients with type 2 diabetes; patients received once-daily lixisenatide in combination with biguanide, thiazolidinedione, alpha-glucosidase inhibitors, or glinide (NCT01940965)...
April 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28429854/application-of-3c-insulin-pump-system-in-combination-with-non-invasive-ventilation-in-the-treatment-of-a-patient-with-type-2-diabetes-and-obstructive-sleep-apnea-syndrome
#2
Peng Dong, Jing Xu, Junhong Wang, Chunhong Zhang
We observed the curative effect of 3C insulin system in combination with non-invasive ventilation in a patient with type 2 diabetes and obstructive sleep apnea syndrome (OSAS). 3C insulin pump is a system of devices that closely monitors and effectively regulates blood glucose levels. Non-invasive ventilation has been shown to be an effective treatment for OSAS. A type 2 diabetic patient with concomitant OSAS was treated with a 3C insulin pump system for real-time continuous glucose monitoring and nocturnal non-invasive ventilation for OSAS...
April 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28429513/distribution-and-hormonal-characterization-of-primary-murine-l-cells-throughout-the-gastrointestinal-tract
#3
Kazuyo Suzuki, Kanako Iwasaki, Yuki Murata, Norio Harada, Shunsuke Yamane, Akihiro Hamasaki, Kimitaka Shibue, Erina Joo, Akiko Sankoda, Yuta Fujiwara, Yoshitaka Hayashi, Nobuya Inagaki
AIMS/INTRODUCTION: Glucagon-like peptide-1 (GLP-1) secreted from enteroendocrine L-cells is an incretin that potentiates insulin secretion and is already applied in therapies for type 2 diabetes. However, detailed examination of L-cells throughout the gastrointestinal (GI) tract remains unclear, because of difficulties in purifying scattered L-cells from other cells. In the present study, we identified characteristics of L-cells of the upper small intestine (UI), the lower small intestine (LI) and the colon using glucagon (Gcg)-green fluorescent protein (GFP)-expressing mice that express GFP driven by the proglucagon promoter...
April 20, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28418217/24-hour-variations-in-blood-glucose-level-in-type-2-diabetic-japanese-based-on-continuous-glucose-monitoring
#4
Maiko Hajime, Yosuke Okada, Hiroko Mori, Takashi Otsuka, Mayuko Kawaguchi, Megumi Miyazaki, Fumi Kuno, Kei Sugai, Satomi Sonoda, Kenichi Tanaka, Akira Kurozumi, Manabu Narisawa, Keiichi Torimoto, Tadashi Arao, Yoshiya Tanaka
AIMS/INTRODUCTION: High fluctuations in blood glucose are associated with various complications. The correlation between glycated hemoglobin (HbA1c) level and fluctuations in blood glucose level has not been studied in Japanese patients with type 2 diabetes (T2DM). In this study, blood glucose profile stratified by HbA1c level was evaluated by continuous glucose monitoring (CGM) in Japanese T2DM patients. MATERIALS AND METHODS: Our retrospective study included 294 patients with T2DM, who were divided by HbA1c level into five groups (≥6...
April 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28418115/aggravation-of-diabetes-and-incompletely-deficient-insulin-secretion-in-a-case-with-type-1-diabetes-resistant-hla-drb1-15-02-treated-with-nivolumab
#5
Kimio Matsumura, Kaoru Nagasawa, Yoichi Oshima, Shouta Kikuno, Kyohei Hayashi, Akihiro Nishimura, Minoru Okubo, Hironori Uruga, Kazuma Kishi, Tetsuro Kobayashi, Yasumichi Mori
Anti-programmed cell death-1 (PD-1) antibody therapy induces various adverse effects especially in endocrine systems. Several cases of acute onset insulin-dependent diabetes after anti-PD-1 antibody therapy have been reported. Many of these cases have a susceptible HLA genotype for type 1 diabetes possibly suggesting that human leukocyte antigen (HLA) might be involved in the onset of diabetes with anti PD-1 therapy. We describe an atypical case of hyperglycemia after anti PD-1 antibody administration. A 68-year-old Japanese man with pancreatic diabetes and steroid diabetes was administered nivolumab three times for chemoresistant adenocarcinoma of the lung...
April 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28406580/low-glucose-induces-mitochondrial-reactive-oxygen-species-via-fatty-acid-oxidation-in-bovine-aortic-endothelial-cells
#6
Nobuhiro Kajihara, Daisuke Kukidome, Kiminori Sada, Hiroyuki Motoshima, Noboru Furukawa, Takeshi Matsumura, Takeshi Nishikawa, Eiichi Araki
AIMS/INTRODUCTION: Overproduction of reactive oxygen species (ROS) in endothelial cells (ECs) plays a pivotal role in endothelial dysfunction. Mitochondrial ROS (mtROS) is one of the key players in the pathogenesis of diabetic vascular complications. Hypoglycemia is linked to increased ROS production and vascular events; however, the underlying mechanisms remain unclear. In this study, we aimed to determine whether and how low glucose (LG) mediates mtROS generation in ECs and to examine the impact of LG-induced mtROS on endothelial dysfunction...
April 12, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28397367/continuous-glucose-monitoring-reveals-hypoglycemia-risk-in-elderly-patients-with-type-2-diabetes-mellitus
#7
Takahiro Ishikawa, Masaya Koshizaka, Yoshiro Maezawa, Minoru Takemoto, Yoshiharu Tokuyama, Toshihiro Saito, Koutaro Yokote
INTRODUCTION: The incidence of type 2 diabetes is higher in elderly patients, in whom this disease is associated with dementia, falling, stroke, and death. We utilized a continuous glucose monitoring (CGM) device to analyze the relationship between hypoglycemia and diabetes treatments to identify risk factors for hypoglycemia (defined as a blood glucose level <70 mg/dL). MATERIALS AND METHODS: We classified 170 patients aged ≥65 years with type 2 diabetes who were receiving steady-state medication (29 of whom were inpatients) into hypoglycemic and non-hypoglycemic groups, and compared their HbA1c levels, treatment types, continuous glucose monitoring data, and other parameters...
April 11, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28390105/marked-alteration-of-glycemic-profile-surrounding-lanreotide-administration-in-acromegaly-a-case-report
#8
Sho Tanaka, Akira Haketa, Shun Yamamuro, Toshiko Suzuki, Hiroki Kobayashi, Yoshinari Hatanaka, Takahiro Ueno, Noboru Fukuda, Masanori Abe, Atsuo Yoshino, Masayoshi Soma
Whether somatostatin analogs for acromegaly improve or worsen a patient's glycemic profile is controversial. A risk of hypoglycemia should be presumed especially when patients receive insulin therapy, as the package inserts caution. However, a detailed clinical course of such a case was never reported in research articles. An 80-year-old Japanese female diabetic treated with insulin therapy was diagnosed with acromegaly, and the somatostatin analog, lanreotide, was administered. On day 4 of administration, repeated hypoglycemia due to exogenous insulin arose and the patient required inpatient care...
April 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28390099/subcutaneous%C3%A2-injection-of-h2-is-a-novel-effective-treatment-for-type-2-diabetes
#9
Xiaolong Zhang, Jiaming Liu, Keke Jin, Haifeng Xu, Chuang Wang, Zhuang Zhang, Mimi Kong, Zhengzheng Zhang, Qingyi Wang, Fangyan Wang
AIMS/INTRODUCTION: In previous studies H2 administration has clearly shown effectiveness in inhibiting diabetes. Here, we evaluated whether subcutaneous injection of H2 shows enhanced efficacy against type 2 diabetes mellitus (T2DM) induced in mice by a high-fat diet and low dose streptozotocin (STZ) treatment. MATERIAL AND METHODS: H2 was injected subcutaneously at a dose of 1ml/mouse/week for four weeks. T2DM associated parameters were then evaluated to determine the effectiveness of subcutaneous H2 administration...
April 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28390093/understanding-the-role-of-the-gut-ecosystem-in-diabetes-mellitus
#10
REVIEW
Wanping Aw, Shinji Fukuda
Diabetes mellitus is a type of metabolic disorder patients are unable to regulate glycemia. It is currently worldwide public health issue and is a burden to society due to its disabling and common complications. Diabetes is multi-factorial and also induces the onset of other diseases. In this report, we will review the labyrinth encompassing the gut microbiota and gut microbiota derived metabolites on type 1 diabetes and type 2 diabetes pathogenesis. There has been exceptional improvements in Deoxyribonucleic acid (DNA) sequencing and mass spectrometry technologies throughout these years and this has allowed the comprehensive collection of information on our unique gut ecosystem...
April 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28387061/gestational-diabetes-mellitus-and-first-trimester-pregnancy-associated-plasma-protein-a-a-case-control-study-in-a-chinese-population
#11
Di Xiao, Chenhong Wang, Yanbin Xu, Zhou Lu
AIMS: To investigate the relationship between pregnancy-associated plasma protein A (PAPP-A) and gestational diabetes mellitus (GDM) and to determine whether PAPP-A has improved value for predicting GDM in a Chinese population. METHODS: Clinical data for 599 GDM patients and 986 unaffected pregnant women undergoing both antenatal examinations and delivery were retrospectively analyzed. First-trimester serum PAPP-A levels were compared between the groups. Binary logistic regression analysis was used to explore the risk factors for GDM, and the area under the receiver operating characteristic (AUC-ROC) curve was used to determine the value of PAPP-A for predicting GDM...
April 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28371567/an-open-label-randomized-study-comparing-basal-insulin-peglispro-and-insulin-glargine-in-combination-with-oral-antihyperglycemic-medications-in-insulin-na%C3%A3-ve-asian-patients-with-type-2-diabetes
#12
Takahisa Hirose, Zhihong Cai, Kwee Poo Yeo, Makoto Imori, Kenji Ohwaki, Takeshi Imaoka
INTRODUCTION: This phase 3, randomized, open-label study compared efficacy and safety of basal insulin peglispro with insulin glargine after 26 weeks of treatment when added to oral antihyperglycemic medications in insulin-naïve Asian patients with type 2 diabetes (T2D). MATERIALS AND METHODS: The primary objective was to show noninferiority in change from baseline to 26 weeks in glycated hemoglobin. RESULTS: At 26 weeks, insulin peglispro was noninferior to glargine, meeting the primary objective...
March 31, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28371517/role-of-vitamin-d-in-energy-and-bone-metabolism-in-postmenopausal-women-with-type-2-diabetes-mellitus-a-6-month-follow-up-evaluation
#13
Makiko Ogata, Naoko Iwasaki, Risa Ide, Miho Takizawa, Mizuho Tanaka, Tamaki Tetsuo, Asako Sato, Yasuko Uchigata
INTRODUCTION: Resting energy expenditure (REE) was associated with a serum bone turnover marker in postmenopausal women with type 2 diabetes (T2DMPW) in our cross-sectional study. To clarify the fundamental pathologic factor for the correlation of bone metabolism and basal metabolism in type 2 diabetes, a 6-month prospective follow-up study was performed with supplementation of vitamin D. METHODS: 44 T2DMPW were enrolled. The following factors were evaluated at the beginning and the end of the summer: procollagen type 1 N-terminal propeptide (P1NP), carboxy-terminal collagen crosslinks-1 (CTX-1), intact parathyroid hormone, and 25[OH]D, as well as diabetic complications, body composition, respiratory quotient(RQ), and REE...
March 31, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28371475/impact-of-non-alcoholic-fatty-pancreas-disease-on-glucose-metabolism
#14
Tse-Ya Yu, Chih-Yuan Wang
With increasing global epidemic of obesity, the clinical importance of non-alcoholic fatty pancreas disease (NAFPD) has grown. Even though the pancreas may be more susceptible to ectopic fat deposition compared with the liver, NAFPD was rarely discussed due to the limitation of detecting techniques. In the past, NAFPD was considered as an innocent condition or just part of clinical manifestations during the course of obesity. Recently, a growing body of research suggests that NAFPD may be associated with β-cell dysfunction, insulin resistance, and inflammation, which possibly leads to the development of diabetes and metabolic syndrome...
March 31, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28371533/preliminary-screening-of-mutations-in-the-glucokinase-gene-of-chinese-patients-with-gestational-diabetes
#15
Zhixin Wang, Fan Ping, Qian Zhang, Jia Zheng, Huabing Zhang, Miao Yu, Wenhui Li, Xinhua Xiao
Mutations in the glucokinase gene (GCK) are a pathogenetic cause of maturity-onset diabetes of the young (MODY). Studies have found that female patients with GCK-MODY often present with gestational diabetes during pregnancy. Our aim was to preliminarily assess the prevalence of mutations in the glucokinase gene in Chinese subjects with gestational diabetes MATERIALS AND METHODS: Chinese gestational subjects who underwent a 100 g oral glucose tolerance test in Peking Union Medical College Hospital (PUMCH) from July 2005 to May 2008 were retrospectively analyzed...
March 30, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28371532/prevalence-of-metabolic-syndrome-in-chinese-psoriatic-patients-a-hospital-based-cross-sectional-study
#16
Gui Xin-Yu, Yu Xiao-Ling, Jin Hong-Zhong, Zuo Ya-Gang, Wu Chao
AIMS: Psoriasis, a chronic autoimmune skin disorder, is believed to contribute to cardiovascular diseases and metabolic syndrome. Psoriasis's association with the components of metabolic syndrome has been reported previously. However, large-scale cross-sectional studies about psoriasis and metabolic syndrome are rare in China. MATERIALS AND METHODS: We assessed the prevalence of metabolic syndrome in Chinese psoriatic patients and controls. RESULTS: 859 psoriatic patients and 1718 controls were recruited in an age- and sex-matched cross-sectional study...
March 30, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28371461/comparison-of-morning-basal-1-bolus-insulin-therapy-insulin-glulisine-insulin-glargine-300-u-ml-vs-insulin-lispro-insulin-glargine-biosimilar-using-continuous-glucose-monitoring-cgm-a-randomized-crossover-study
#17
Soichi Takeishi, Hiroki Tsuboi, Shodo Takegoshi
AIMS/INTRODUCTION: We compared the effects of morning administration of insulin glulisine + insulin glargine 300 U/ml (G+G300) to that of insulin lispro + insulin glargine biosimilar (L+GB). MATERIALS AND METHODS: 30 patients with type 2 diabetes who wear continuous glucose monitoring device in admission after glucose levels were stabilized by morning long-acting and ultra-rapid-acting insulins were randomly allocated to groups who received G+G300 on days 1 and 2 and the same dose L+GB on days 3 and 4, or vice versa...
March 28, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28371446/physical-activity-and-prevalence-of-erectile-dysfunction-in-japanese-patients-with-type-2-diabetes-mellitus-the-dogo-study
#18
Hisaka Minami, Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Sayaka Kanzaki, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake
AIMS/INTRODUCTION: No evidence regarding the association between physical activity (PA) and erectile dysfunction (ED) among Japanese patients with type 2 diabetes mellitus. We estimated this issue among Japanese patients with type 2 diabetes mellitus. MATERIALS AND METHODS: Study subjects were 460 male Japanese patients with type 2 diabetes mellitus. The definitions of exercise habit, walking habit, and fast walking were based on a self-administered questionnaire regarding PA behavior...
March 28, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28349643/causes-of-death-in-japanese-patients-with-diabetes-based-on-the-results-of-a-survey-of-45-708-cases-during-2001-2010-report-of-the-committee-on-causes-of-death-in-diabetes-mellitus
#19
Jiro Nakamura, Hideki Kamiya, Masakazu Haneda, Nobuya Inagaki, Yukio Tanizawa, Eiichi Araki, Kohjiro Ueki, Takeo Nakayama
The principal causes of death among 45,708 patients with diabetes (29,801 men and 15,907 women) who died in 241 hospitals throughout Japan during 2001-2010 were determined based on a survey of the hospital records. Autopsy had been conducted in 978 of the 45,708 cases. The most frequent cause of death was malignant neoplasia (38.3%), followed by, in order of descending frequency: infections (17.0%); and then vascular diseases (14.9%), including renal failure (3.5%), ischemic heart diseases (4.8%) and cerebrovascular diseases (6...
March 27, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28296349/dipeptidyl-peptidase-4-inhibitors-as-preferable-oral-hypoglycemic-agents-in-terms-of-treatment-satisfaction-results-from-a-multicenter-12-week-open-label-randomized-controlled-study-in-japan
#20
Hitoshi Ishii, Yasuaki Hayashino, Yasuhiro Akai, Matahiro Yabuta, Satoru Tsujii
AIMS/INTRODUCTION: To compare the treatment satisfaction of four classes of oral hypoglycemic agents (OHAs): dipeptidyl peptidase-4 (DPP-4) inhibitors, α-glucosidase inhibitors (αGI), biguanides (BG), and sulfonylureas (SU), which are common initial treatments for type 2 diabetes mellitus patients in Japan, and to identify the best OHA in terms of treatment satisfaction. MATERIALS AND METHODS: In this 12-week, randomized, controlled, open-label study, Japanese outpatients with type 2 diabetes mellitus who were naïve to pharmacological treatment were randomly assigned a DPP-4 inhibitor, a BG, an αGI, or a SU...
March 14, 2017: Journal of Diabetes Investigation
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