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Journal of Diabetes Investigation

Lin Han, Yuxia Ma, Suhong Wei, Jinhui Tian, Xiaochun Yang, Xiping Shen, Jun Zhang, Yuexian Shi
AIMS: Previous reviews have revealed uncertainty regarding the effectiveness of home visit interventions for managing diabetes. Therefore, we performed a quantitative systematic review and meta-analysis to evaluate the effects of home visit interventions among patients with diabetes. METHODS: We searched various electronic databases (PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, Wanfang, and Chinese scientific full-text databases) from their inception until March 2016...
January 21, 2017: Journal of Diabetes Investigation
Yujiro Ina, Yumiko Kawabata, Ryuichi Sakamoto, Naotaka Sekiguchi, Hiroshi Ikegami
Multiplex families with type 1 diabetes are important for identification of rare variants that cannot be identified in case-control association studies. Very low incidence of type 1 diabetes in Japanese population, however, makes identification of such families difficult. We identified a Japanese family in which three members developed type 1 diabetes, and studied the genotype of the HLA. All three members with type 1 diabetes had the DRB1*08:02-DQB1*03:02 haplotype, which is specific to the Asian population and strongly susceptible for type 1 diabetes...
January 20, 2017: Journal of Diabetes Investigation
Li-Jing Sun, Yan-Ni Sun, Jian-Ping Shan, Geng-Ru Jiang
AIMS: We aimed to evaluate the potential benefits and adverse effects of adding a mineralocorticoid receptor antagonist (MRA) to angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin receptor blockers (ARB), as standard treatment in patients with DN. MATERIALS AND METHODS: We scanned the Embase, PubMed, and Cochrane Central Register of Controlled Trials databases for human clinical trials published in English until June 2016, evaluating renal outcomes in patients with DN...
January 20, 2017: Journal of Diabetes Investigation
Kazunori Utsunomiya, Naoki Shimmoto, Masayuki Senda, Yuji Kurihara, Ryoji Gunji, Shoko Fujii, Seigo Kakiuchi, Hisataka Fujiwara, Hiroyuki Kameda, Masahiro Tamura, Kohei Kaku
AIMS/INTRODUCTION: While sodium glucose cotransporter 2 inhibitors are a promising treatment for type 2 diabetes mellitus, they are associated with concerns about specific adverse drug reactions. We conducted a 1-year post-marketing study of tofogliflozin, a novel agent in this class, in Japanese elderly patients with type 2 diabetes mellitus. MATERIALS AND METHODS: This was a prospective, observational, and multicenter post-marketing study conducted in the context of routine clinical practice...
January 20, 2017: Journal of Diabetes Investigation
Xiaoling Cai, Liwei Ji, Yifei Chen, Wenjia Yang, Lingli Zhou, Xueyao Han, Simin Zhang, Linong Ji
To evaluate the efficacy of weight changes from baseline of the SGLT2 inhibitors treatment and GLP-1 analogs treatment after comparisons with placebo in type 2 diabetes patients and the associated factors MATERIALS AND METHODS: Studies were searched from when recording began, June 2004, until June 2015, and re-searched on July 2016, and placebo-controlled randomized trials in type 2 diabetes patients with a study length ≥12 weeks were included RESULTS: A total of 97 RCTs were included. Compared with placebo, treatment with SGLT2 inhibitors was associated with a significant greater decrease in weight change from baseline, (weighted mean differences (WMD), -2...
January 20, 2017: Journal of Diabetes Investigation
Yosuke Hirakawa, Tetsuhiro Tanaka, Masaomi Nangaku
Diabetic kidney disease (DKD) is a worldwide public health problem. The definition of DKD is being under discussion. Although the term DKD was originally defined as "kidney disease specific to diabetes", DKD frequently means chronic kidney disease (CKD) with diabetes mellitus and includes not only classical diabetic nephropathy, but also kidney dysfunction due to nephrosclerosis and other causes. Metabolic memory plays a crucial role in the progression of various complications of diabetes, including DKD. The mechanisms of metabolic memory in DKD are supposed to include advanced glycation end products, DNA methylation, histone modifications, and non-coding RNA including microRNA...
January 17, 2017: Journal of Diabetes Investigation
Kenta Takei, Song-Iee Han, Yuki Murayama, Aoi Satoh, Fusaka Oikawa, Hiroshi Ohno, Yoshinori Osaki, Takashi Matsuzaka, Motohiro Sekiya, Hitoshi Iwasaki, Shigeru Yatoh, Naoya Yahagi, Hiroaki Suzuki, Nobuhiro Yamada, Yoshimi Nakagawa, Hitoshi Shimano
AIMS/INTRODUCTION: Peroxisome proliferator-activated receptor α (PPARα) is a therapeutic target for hyperlipidemia. K-877 is a new selective PPARα modulator (SPPARMα) that activates PPARα transcriptional activity. The aim of the present study was to assess the effects of K-877 on lipid metabolism in vitro and in vivo compared with those of classical PPARα agonists. MATERIALS AND METHODS: To compare the effects of K-877 on PPARα transcriptional activity with those of the classical PPARα agonists Wy14643 (Wy) and fenofibrate (Feno), the cell-based PPARα transactivation luciferase assay was performed...
January 13, 2017: Journal of Diabetes Investigation
Hongbo Yang, Jiuliang Zhao, Yuepeng Li, Fang Lv, Songyun Zhang, Yuxiu Li
INTRODUCTION: Type B insulin resistance syndrome is a very rare condition caused by autoantibodies against the insulin receptor. We report the successful treatment of a patient with refractory type B insulin resistance with pulse glucocorticoids and cyclophosphamide. MATERIALS AND METHODS: The medical record of a patient with type B insulin resistance was reviewed. RESULTS: A 36 year-old Chinese lady presented with menopause, weight loss and refractory hyperglycemia for three months, which could not be controlled by up to 972 of insulin units per day...
January 13, 2017: Journal of Diabetes Investigation
Kumiko Yoshimura, Seiki Hirano, Hiroshi Takata, Shogo Funakoshi, Satoko Ohmi, Eri Amano, Yuichi Nishi, Mari Inoue, Yoshiharu Fukuda, Hikari Hayashi, Tadao Taguchi, Shuhei Yamada, Ichitomo Miwa, Yoshio Terada, Shimpei Fujimoto
AIMS/INTRODUCTION: Mannose is a monosaccharide constituent of glycoproteins and glycolipids. Experiments in rats have shown previously that the plasma mannose level decreases after glucose load but does not decrease in diabetic rats and that hepatic glycogenolysis is a source of this plasma mannose; however these results are not fully elucidated in humans. Plasma mannose levels before/after glucose loading in human subjects with various degrees of glucose intolerance was examined to analyze their association with clinical factors...
January 13, 2017: Journal of Diabetes Investigation
Sorin Ioacara, Sarah Flanagan, Elke Fröhlich-Reiterer, Robin Goland, Fica Simona
In this report, we present the first known case of intermediate DEND (Developmental delay, Epilepsy and permanent Neonatal Diabetes) syndrome caused by a Q52R mutation in the KCNJ11 gene who was successfully switched (at age 1.3 years) to sulphonylurea monotherapy, namely glibenclamide. The latest evaluation, after two years showed a glycated hemoglobin of 6.0% (42 mmol/mol). This mutation is so severe that none of the previously four reported cases were able to switch from insulin to sulphonylurea monotherapy...
January 13, 2017: Journal of Diabetes Investigation
Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Chika Horikawa, Nobumasa Ohara, Yoko Yachi, Shiro Tanaka, Hitoshi Shimano, Kiminori Kato, Osamu Hanyu, Hirohito Sone
AIMS/INTRODUCTION: This meta-analysis aimed to clarify the association of unstable body weight with the risk of type 2 diabetes mellitus (T2DM), an association that has been controversial among longitudinal studies. MATERIALS AND METHODS: Electronic literature search using EMBASE and MEDLINE was followed up to Aug. 31, 2016. The relative risks (RRs) of T2DM in individuals with unstable body weight were pooled using the inverse variance method. RESULTS: Eight studies were eligible for the meta-analysis...
January 13, 2017: Journal of Diabetes Investigation
Maryam Moghani Lankarani, Shervin Assari
INTRODUCTION: Diabetes, hypertension, and obesity increase risk of chronic kidney disease and associated mortality. Race and SES differences in the effects of these risk factors are, however, still unknown. Current study aimed to investigate whether or not race and SES alter the effects of diabetes, hypertension, and obesity on mortality due to renal diseases. MATERIALS AND METHODS: Data came from the Americans' Changing Lives Study (ACL), 1986 to 2011, a nationally representative prospective cohort of adults with 25 years of follow up...
January 11, 2017: Journal of Diabetes Investigation
Shamima Akter, Akiko Nanri, Keisuke Kuwahara, Yumi Matsushita, Tohru Nakagawa, Maki Konishi, Toru Honda, Shuichiro Yamamoto, Takeshi Hayashi, Mitsuhiko Noda, Tetsuya Mizoue
AIMS/INTRODUCTION: Higher iron storage has been linked to increased risk of type 2 diabetes, but little is known about the mediator of this association. Here, we prospectively investigated the association between circulating ferritin, a marker of iron storage, and the incidence of type 2 diabetes among Japanese. METHODS: Subjects were 4754 employees who attended a comprehensive health checkup in 2008-2009 and donated blood for the study. During 5 years of follow-up, diabetes was identified based on plasma glucose, glycated hemoglobin, and self-report...
January 6, 2017: Journal of Diabetes Investigation
Daisuke Koya
Diabetic kidney disease is a leading cause of end stage kidney disease requiring renal transplantation or dialysis in not only Asian but also western countries. Recent data has also implicated that the prevalence of diabetic kidney disease was similar between 1988 and 2014 in cross-sectional studies of adults aged 20 years or older with diabetes mellitus participating in National Health and Nutrition Examination Surveys 1), although newly introduced treatments such as renin-angiotensin-aldosterone system inhibitors did affect the prevalence and clinical manifestations of diabetic kidney disease...
December 30, 2016: Journal of Diabetes Investigation
Yuanyuan Li, Wenzhuo Ran, Jiaqiang Zhang, Shi Chen, Yihang Li, Deng Luo, Chen Wang, Weiping Jia
AIMS/INTRODUCTION: Milk fat globule-epidermal growth factor 8 (MFG-E8) is the key mediator in anti-inflammatory responses that facilitate phagocytosis of apoptotic cells and play an essential role in type 2 diabetes and pregnancy, both of which are under a low-grade inflammatory state. However, the action of MFG-E8 in gestational diabetes mellitus (GDM) is unclear. We measured for the first time plasma MFG-E8 levels in pregnancy and GDM, and elucidated possible relationships between its plasma levels and various metabolic parameters...
December 30, 2016: Journal of Diabetes Investigation
Cai Chen, Yan Yang, Xuefeng Yu, Shuhong Hu, Shiying Shao
AIMS/INTRODUCTION: Epidemiologic evidences for the effect of omega 3 fatty acids on the risk of type 2 diabetes (T2D) are controversial. A meta-analysis based on prospective cohorts was conducted to evaluate this issue. MATERIALS AND METHODS: Pooled diabetic risk was calculated using fixed or random effects model. Dose-response relationship was assessed by meta-regression analysis. RESULTS: Our study revealed that consumption of single omega-3 was associated with an increased risk of T2D (Relative Risk, RR=1...
December 29, 2016: Journal of Diabetes Investigation
Satoko Yamaguchi, Kayo Waki, Nobuko Tomizawa, Hironori Waki, Yasuhito Nannya, Masaomi Nangaku, Takashi Kadowaki, Kazuhiko Ohe
AIMS/INTRODUCTION: Preventing dropout is crucial in managing diabetes. Accordingly, we investigated whether patients who had dropped out of diabetic care are suitable candidates for the use of mobile technologies-such as smartphone applications-to support self-management (mHealth), which might help prevent dropout. MATERIALS AND METHODS: We conducted a cross-sectional study in Tokyo, Japan. Patients age 20 or older who were clinically diagnosed as diabetic and who regularly visited the outpatient unit at the University of Tokyo Hospital were recruited between August 2014 and March 2015...
December 24, 2016: Journal of Diabetes Investigation
Shaoyan Chang, Zhen Wang, Lihua Wu, Xiaolin Lu, Shaofang Shangguan, Yu Xin, Li Li, Li Wang
BACKGROUND: Studies have been conducted to evaluate the correlation between TCF7L2 genetic polymorphisms and GDM risk. However, the conclusions from these studies are incomplete because partial SNPs were analyzed. We performed a meta-analysis aimed to evaluate systematically TCF7L2 gene polymorphisms and GDM susceptibility in all population and racial/ethnic subgroups to afford a foundation for future research. METHODS: Published studies censoring TCF7L2 variants and GDM risk were captured from EMBASE, PubMed, CNKI and Wanfang databases...
December 21, 2016: Journal of Diabetes Investigation
Xiang Hu, Xiaojing Ma, Yuqi Luo, Yiting Xu, Qin Xiong, Xiaoping Pan, Yuqian Bao, Weiping Jia
INTRODUCTION: Individuals with type 2 diabetes mellitus (T2DM) were vulnerable to micro- and macrovascular complications in the presence of microalbuminuria. Adipocyte fatty acid binding protein (A-FABP) was proposed as an indicator for albuminuria in patients with diabetes. The present study aimed to explore the associations between serum A-FABP levels and microalbuminuria in the hyperglycemic population. MATERIALS AND METHODS: Serum A-FABP levels were detected using sandwich enzyme-linked immunosorbent assay...
December 19, 2016: Journal of Diabetes Investigation
Toshiko Takao, Machi Suka, Hiroyuki Yanagisawa, Yasuhiko Iwamoto
AIMS/INTRODUCTION: We evaluated the impact of postprandial hyperglycemia at clinic visits on the incidence of cardiovascular diseases (CVD) and all-cause mortality independently of mean glycosylated hemoglobin (HbA1c) in type 2 diabetes patients in a real-world setting. MATERIALS AND METHODS: This retrospective observational cohort study included 646 type 2 diabetes patients. All of the subjects had their initial consultations at our clinic during the period from 1995-1996, visited the clinic ≥4 times, had their 2-hour post-breakfast blood glucose (2h-PBBG) levels measured, and were followed-up for ≥1 year...
December 15, 2016: Journal of Diabetes Investigation
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