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Journal of Diabetes Investigation

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https://www.readbyqxmd.com/read/28646618/tryptophan-as-a-surrogate-prognostic-marker-for-diabetic-nephropathy
#1
Chien-An Chou, Chia-Ni Lin, Daniel Tsun-Yee Chiu, I-Wen Chen, Szu-Tah Chen
AIMS/INTRODUCTION: Diabetic nephropathy is one of the leading causes of end-stage renal disease. Unfortunately, reliable surrogate markers for predicting the prognostic outcome of diabetic nephropathy were as yet absent. In order to find new markers in predicting the progression of diabetic nephropathy, we conducted a prospective study by investigating the correlation between serum metabolites and the annual change of estimated glomerular filtration rate (eGFR). MATERIALS AND METHODS: From September 2013 to September 2015, 52 diabetic patients at various stages of chronic kidney disease (CKD) were enrolled...
June 24, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28644562/efficacy-of-ipragliflozin-as-monotherapy-or-as-add-on-therapy-with-other-oral-antidiabetic-medications-in-treating-type-2-diabetes-in-japanese-patients-with-inadequate-glycemic-control-a-subgroup-analysis-based-on-patient-characteristics
#2
Takeshi Osonoi, Shinya Nakamoto, Miyoko Saito, Atsuko Tamasawa, Hidenori Ishida, Yusuke Osonoi
AIMS/INTRODUCTION: The aim of the present study was to evaluate the efficacy and safety of ipragliflozin in treating Japanese type 2 diabetic patients with inadequate glycemic control by investigating diurnal variations of blood glucose and body composition. MATERIALS AND METHODS: This was an investigator-initiated, multicenter, prospective study with a 6-month treatment period. The primary outcome investigated was change in hemoglobin A1c levels from baseline. Secondary outcomes included changes in fasting plasma glucose, insulin resistance, variations in 24-h glucose levels detected by continuous glucose monitoring, body weight, body composition, waist circumference, and serum lipids...
June 23, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28626953/translation-and-validation-of-the-insulin-treatment-appraisal-scale-in-hong-kong-primary-care-patients
#3
K P Lee
AIM: Patients with type 2 diabetes mellitus (DM) often delay the initiation or titration of insulin treatment due to psychological factors. This phenomenon is referred to as psychological insulin resistance (PIR). The insulin treatment appraisal scale (ITAS) is a 20-item instrument for assessing PIR. A previous Chinese version of the ITAS (C-ITAS) was found to be subject to problems arising from its translation. The present study aimed to translate and validate this instrument, which will facilitate research and aid in counselling in a clinical setting...
June 19, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28613394/regular-exercise-behavior-is-related-to-lower-extremity-muscle-strength-in-patients-with-type-2-diabetes-data-from-the-muscle-std-study
#4
Takuo Nomura, Tomoyasu Ishiguro, Masayoshi Ohira, Yukio Ikeda
Owing to several contributing factors, continuation of exercise therapy is difficult in patients with type 2 diabetes. One potential factor that has not been well examined is the influence of muscle strength on regular exercise behavior. We examined the relationship between regular exercise behavior and knee extension force (KEF) in 1,442 patients with type 2 diabetes. In sex-specific univariate analysis, KEF was significantly higher in patients with regular exercise than in patients without regular exercise...
June 14, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28609558/ipsc-technology-based-regenerative-therapy-for-diabetes
#5
REVIEW
Yasushi Kondo, Taro Toyoda, Nobuya Inagaki, Kenji Osafune
The directed differentiation of human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), into pancreatic endocrine lineages has been vigorously examined by reproducing the in vivo developmental processes of pancreas. Recent advances in this research field have enabled the generation from hESCs/iPSCs of functionally mature β-like cells in vitro that show glucose-responsive insulin secretion ability. The therapeutic potentials of hESC/iPSC-derived pancreatic cells have been evaluated using diabetic animal models, and transplantation methods including immunoprotective devices that prevent immune responses from hosts to the implanted pancreatic cells have been investigated towards the development of regenerative therapies against diabetes...
June 13, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28597607/immaturity-of-insulin-secretion-by-pancreatic-islets-isolated-from-one-human-neonate
#6
Jean-Claude Henquin, Myriam Nenquin
Human β-cells are functionally mature by the age of one year. The timing and mechanisms of this maturation are unknown owing to the exceptional availability of testable tissue. Here, we report the first in vitro study of insulin secretion by islets from a 5 day-old newborn. Glucose alone was inefficient but glucose-stimulation became concentration-dependent, displayed a biphasic time-course and was of similar magnitude as in infant islets when β-cell cAMP was raised by forskolin. Tolbutamide alone was effective in low glucose, but its effect was not augmented by high glucose...
June 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28593750/impact-of-obesity-on-mortality-in-patients-with-diabetes-meta-analysis-of-20-studies-including-250-016-patients
#7
Fei Gao, Zhi Jian Wang, Hua Shen, Shi Wei Yang, Bin Nie, Yu Jie Zhou
AIMS/INTRODUCTION: The impact of body mass index on mortality among patients with diabetes remains controversial. Therefore, we carried out a meta-analysis of pertinent studies. MATERIALS AND METHODS: We searched OVID/MEDLINE, EMBASE and Cochrane databases for all reported studies, which investigated the relationship between body mass index and mortality in patients with diabetes. Summary estimates of hazard ratios (HRs) were obtained with a random effects model...
June 8, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28563974/performance-of-a-new-real-time-continuous-glucose-monitoring-system-a-multicenter-pilot-study
#8
Jian Zhou, Shuo Zhang, Liang Li, Yufei Wang, Wei Lu, Chunjun Sheng, Yiming Li, Yuqian Bao, Weiping Jia
BCAKGROUND: This study was to investigate the performance of a new real-time continuous glucose monitoring (RT-CGM) system. METHODS: Interstitial glucose levels were monitored for 7 days in 63 patients with type 1 or type 2 diabetes using the Medtrum A6 TouchCare(®) CGM System. Venous blood was collected on a randomized day of the wear period. Plasma glucose levels were measured as reference values. RESULTS: Among 1,678 paired sensor-reference values, 90...
May 31, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28556616/fast-acting-insulin-aspart-in-japanese-patients-with-type-1-diabetes-faster-onset-higher-early-exposure-and-greater-early-glucose-lowering-effect-relative-to-insulin-aspart
#9
Masanari Shiramoto, Tomoyuki Nishida, Ann Kathrine Hansen, Hanne Haahr
AIMS/INTRODUCTION: Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with two added excipients (niacinamide and L-arginine) in order to obtain accelerated absorption after subcutaneous dosing. This study compared the pharmacokinetic/pharmacodynamic characteristics of faster aspart vs. IAsp in Japanese patients with type 1 diabetes (T1D). MATERIALS AND METHODS: In a randomized, double-blind, crossover design, 43 participants were administered faster aspart and IAsp (0...
May 27, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28556518/low-hba1c-level-is-associated-with-severity-of-frailty-in-japanese-elderly-diabetic-patients
#10
Ikumi Yanagita, Yuya Fujihara, Terumi Eda, Misuzu Tajima, Kazue Yonemura, Tomoko Kawajiri, Noriko Yamaguchi, Hideko Asakawa, Yukiko Nei, Yumi Kayashima, Mihoko Yoshimoto, Yuichi Kitajima, Mayumi Harada, Yuhei Araki, Syoji Yoshimoto, Eiji Aida, Toshihiko Yanase, Hajime Nawata, Kazuo Muta
AIMS/INTRODUCTION: Previously, a study using a narrowly defined (physical base) frailty scale reported that both good and bad (U-shaped curve) HbA1c levels were frailty risk factors in patients with type 2 diabetes mellitus (T2DM). However, no such studies have demonstrated this in Japan. We aimed to evaluate the frailty risk factors including HbA1c in elderly Japanese patients with T2DM using a broadly defined (both physical and psychosocial base) frailty scale, the Clinical Frailty Scale (CFS)...
May 27, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28520234/bullous-pemphigoid-associated-with-dipeptidyl-peptidase-4-inhibitors-a-report-of-five-cases
#11
Satoshi Yoshiji, Takaaki Murakami, Shin-Ichi Harashima, Rie Ko, Riko Kashima, Daisuke Yabe, Masahito Ogura, Kentaro Doi, Nobuya Inagaki
Bullous pemphigoid (BP) is an autoimmune blistering skin disorder. Recently, BP induced by dipeptidyl peptidase-4 (DPP-4) inhibitors has been a concern. Although DPP-4 inhibitors are commonly used in the Asian population due to their safety and efficacy, BP associated with DPP-4 inhibitors is sometimes seen in clinical settings. Here we report five Japanese cases of BP associated with the agents. In our cases, BP occurred in the elderly by 4 different DPP-4 inhibitors, which showed various clinical manifestations in terms of latency period for BP, sex, glycemic control, and diabetes duration...
May 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28519964/association-between-serum-25-hydroxyvitamin-d-and-glycated-hemoglobin-levels-in-type-2-diabetes-patients-with-chronic-kidney-disease
#12
Lee Ling Lim, Yong Muh Ng, Pei San Kang, Soo Kun Lim
AIMS/INTRODUCTION: Vitamin D is suggested to influence glucose homeostasis. An inverse relationship between serum 25-hydroxyvitamin D [25(OH)D] and glycemic control in non-chronic kidney disease (CKD) patients with type 2 diabetes (T2D) was reported. We aimed to examine this association among T2D patients with CKD. MATERIALS AND METHODS: 100 T2D participants with stage 3-4 CKD were recruited. Blood for HbA1c , serum 25(OH)D, renal, and lipid profiles were drawn at enrolment...
May 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28502112/sglt2-inhibitor-luseogliflozin-added-to-glucagon-like-peptide-1-receptor-agonist-liraglutide-improves-glycemic-control-with-bodyweight-and-fat-mass-reductions-in-japanese-patients-with-type-2-diabetes-a-52-week-open-label-single-arm-study
#13
Yutaka Seino, Daisuke Yabe, Takashi Sasaki, Atsushi Fukatsu, Hisae Imazeki, Hidekazu Ochiai, Soichi Sakai
AIMS/INTRODUCTION: To evaluate the safety and efficacy of luseogliflozin added to liraglutide monotherapy in Japanese individuals with type 2 diabetes (T2D). MATERIALS AND METHODS: This 52-week, multicenter, open-label, single-arm clinical study enrolled Japanese patients who had inadequate glycemic control with diet/exercise and liraglutide monotherapy. Major efficacy endpoints included the changes from baseline in HbA1c, fasting plasma glucose (FPG), and bodyweight...
May 14, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28494143/the-normal-meal-tolerance-test-is-preferable-to-the-glucagon-stimulation-test-in-patients-with-type-2-diabetes-that-are-not-in-a-hyperglycemic-state-comparison-with-the-change-of-%C3%AE-cpr
#14
Youhei Fujioka, Tsuyoshi Ohkura, Keisuke Sumi, Kazuhisa Matsumoto, Kyoko Shoji, Risa Nakamura, Kazuhiko Matsuzawa, Shoichiro Izawa, Masahiko Kato, Shinichi Taniguchi, Kazuhiro Yamamoto
AIMS: The aim of this study was to evaluate the properties of the glucagon stimulation test (GST) and the normal meal tolerance test (NMTT) in patients with type 2 diabetes. MATERIALS AND METHODS: We enrolled 142 patients with type 2 diabetes and performed a GST and a NMTT. We performed the NMTT using a calorie-controlled meal based on an intake of 30 kcal/kg ideal body weight/day. We calculated the change in C-peptide immunoreactivity (ΔCPR) by subtracting fasting CPR from the CPR 6 min after the 1 mg glucagon injection (GST) or 120 min after the meal (NMTT)...
May 11, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28494142/blood-pressure-circadian-rhythms-and-adverse-outcomes-in-type-2-diabetes-patients-diagnosed-with-orthostatic-hypotension
#15
Jing Chang, Yuan-Ping Hou, Jin-Ling Wu, Xiang-Yang Fang, Sheng-Li Li, Miao-Bing Liu, Qian-Mei Sun
AIMS/INTRODUCTION: Patients with diabetes frequently develop orthostatic hypotension (OH). The present study was designed to examine the relationship of blood pressure (BP) circadian rhythms and outcomes in diabetes with OH. MATERIALS AND METHODS: In the present study, 173 inpatients with type 2 diabetes were enrolled. Patients were divided into an OH group and a non-OH group according to the BP changes detected in the supine and standing position. Then, 24-h ambulatory BP was monitored...
May 11, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28494126/real-life-glycemic-control-in-patients-with-type-2-diabetes-treated-with-insulin-therapy-a-prospective-longitudinal-cohort-study-diabetes-distress-and-care-registry-at-tenri-ddcrt-9
#16
Naotaka Fujita, Yosuke Yamamoto, Yasuaki Hayashino, Hirohito Kuwata, Shintaro Okamura, Tadao Iburi, Miyuki Furuya, Masako Kitatani, Shin Yamazaki, Hitoshi Ishii, Satoru Tsujii, Nobuya Inagaki, Shunichi Fukuhara
AIMS/INTRODUCTION: We investigated the association between four insulin regimens and increase in HbA1c and insulin dose in a real-life clinical setting because there is no data about them among insulin regimens. MATERIALS AND METHODS: Subjects included 757 patients with type 2 diabetes having been treated with insulin therapy for more than 1 year. The four insulin regimens were regimen 1 (long-acting insulin, once daily), regimen 2 (biphasic insulin, twice daily), regimen 3 (biphasic insulin, three times daily), and regimen 4 (basal-bolus therapy)...
May 11, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28477380/antibodies-against-h1n1-influenza-virus-cross-react-with-alpha-cells-of-pancreatic-islets
#17
Zongli Qi, Hanyu Hu, Zhihua Wang, Guanghua Wang, Yan Li, Xiangrong Zhao, Yangmeng Feng, Xueping Huo, Jingying Sun, Qing Feng, Yang Liu, Nana Wang, Chunyan Guo, Yuan Li, Ruian Wang, Jun Hu
Epidemiological studies have documented that the incidence of human type 1 diabetes (T1D) is significantly increased after H1N1 epidemic. However, direct link between T1D and virus infection remains elusive. We generated 84 clones of murine mAbs against the H1N1 and performed immunohistochemistry in normal human tissue microarray. The results demonstrated that two clones specifically cross-reacted with human pancreatic tissues α cell of pancreatic islet. RT-PCR and DNA sequencing showed that the amino acid sequences of light and heavy chains of these clones were different...
May 6, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28445618/ficolin-3-adiponectin-ratio-for-the-prediction-of-gestational-diabetes-mellitus-in-pregnant-women
#18
Xiao-Song Yuan, Hui Shi, Hui-Yan Wang, Bin Yu, Jian Jiang
AIMS/INTRODUCTION: To establish that the ficolin-3/adiponectin ratio is a predictor for gestational diabetes mellitus (GDM) and was eligible for screening tests for GDM. MATERIALS AND METHODS: A prospective cohort study of 86 pregnant women who developed GDM and 273 normal glucose tolerance (NGT) participants was performed. Maternal serum ficolin-3, adiponectin levels were investigated at 16-18 weeks gestation using ELISA. RESULTS: Compared to the NGT group, the GDM group showed significantly higher levels of ficolin-3 and the ratio of ficolin-3/adiponectin; and decreased levels of adiponectin between 16 to 18 weeks of gestation (P < 0...
April 26, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28434196/role-of-gut-microbiota-bile-acids-and-their-crosstalk-in-the-effects-of-bariatric-surgery-on-obesity-and-type-2-diabetes
#19
Haijun Liu, Cheng Hu, Xueli Zhang, Weiping Jia
Type 2 diabetes mellitus is becoming increasingly prevalent worldwide and has become one of the greatest threats to global health. Bariatric surgery was initially designed to achieve weight loss and subsequently was noted to induce improvements or remission of type 2 diabetes. Currently, these bariatric operations such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are the most effective procedures for the treatment of obesity and type 2 diabetes mellitus worldwide. However, the specific mechanism mediating the beneficial effects of metabolic surgery has remained largely unknown...
April 23, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28429860/safety-tolerability-and-efficacy-of-lixisenatide-in-combination-with-oral-antidiabetic-treatment-in-japanese-patients-with-type-2-diabetes-an-open-label-multicenter-study
#20
Yutaka Seino, Aleksandra Stjepanovic, Akane Takami, Hiroki Takagi
AIM/INTRODUCTION: To assess overall safety and efficacy of lixisenatide in combination with background oral antidiabetic drug treatment in Japanese patients with type 2 diabetes, as required by Japanese guidelines. MATERIALS AND METHODS: A Phase 3, multicenter, uncontrolled, open-label, four-arm, parallel-group study in Japanese outpatients with type 2 diabetes; patients received once-daily lixisenatide in combination with biguanide, thiazolidinedione, alpha-glucosidase inhibitors, or glinide (NCT01940965)...
April 21, 2017: Journal of Diabetes Investigation
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