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Oncology Reviews

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https://www.readbyqxmd.com/read/30101003/the-radiation-therapy-options-of-intracranial-hemangiopericytoma-an-overview-and-update-on-a-rare-vascular-mesenchymal-tumor
#1
Maria Paola Ciliberti, Rosa D'Agostino, Laura Gabrieli, Anna Nikolaou, Angela Sardaro
Hemangiopericytoma (HPC) is an extremely rare hypervascular tumor of mesenchymal lineage. It tends to recur and to develop distant metastases even many years after primary surgical resection. The management of recurrent and metastatic disease is not always so well defined. A complete surgical resection does not eliminate the high risk of local recurrences that occur in the central nervous system, often in the same surgical bed. However, treatment with adjuvant radiotherapy even in cases of complete resection remains controversial...
July 4, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/30093983/testosterone-prolactin-and-oncogenic-regulation-of-the-prostate-gland-a-new-concept-testosterone-independent-malignancy-is-the-development-of-prolactin-dependent-malignancy
#2
Leslie C Costello, Renty B Franklin
Hormone-independent malignancy is a major issue of morbidity and deaths that confronts prostate cancer. Despite decades of research, the oncogenic and hormonal implications in the development and progression of prostate malignancy remain mostly speculative. This is largely due to the absence and/or lack of consideration by contemporary clinicians and biomedical investigators regarding the established implications of the co-regulation of testosterone and prolactin in the development, maintenance, metabolism and functions of the prostate gland...
July 4, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/30093982/clinical-development-of-ret-inhibitors-in-ret-rearranged-non-small-cell-lung-cancer-update
#3
Luis Mendoza
Precision oncology is now the evidence-based standard of care for the management of many advanced non-small cell lung cancers (NSCLC). Notably, new molecular profiling technologies have permitted dynamic growth in the identification of actionable driver oncogenes including RET rearrangements. RET oncogenes cannot be adequately detected by immunohistochemistry, although fluorescence in situ hybridization, reverse transcriptase polymerase chain reaction and next-generation sequencing are complementary diagnostic tools...
July 4, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/30057691/cancer-oriented-biobanks-a-comprehensive-review
#4
Shankargouda Patil, Barnali Majumdar, Kamran Habib Awan, Gargi S Sarode, Sachin C Sarode, Amol R Gadbail, Shailesh Gondivkar
Biobanks provide a platform for innovative biomedical research and has improvised translational and personalized medicine to a great extent. Time 2009 published 10 ideas changing the world right now with biobanks on the list emphasizing its role in discovery and development of new therapeutic drugs. They form the cornerstone, providing resources for future investigations and biomarker discovery to understand the effects of genetic, environmental and lifestyle factors on human morbidity, mortality and health...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/30057690/her3-signaling-and-targeted-therapy-in-cancer
#5
Rosalin Mishra, Hima Patel, Samar Alanazi, Long Yuan, Joan T Garrett
ERBB family members including epidermal growth factor receptor (EGFR) also known as HER1, ERBB2/HER2/Neu, ERBB3/HER3 and ERBB4/HER4 are aberrantly activated in multiple cancers and hence serve as drug targets and biomarkers in modern precision therapy. The therapeutic potential of HER3 has long been underappreciated, due to impaired kinase activity and relatively low expression in tumors. However, HER3 has received attention in recent years as it is a crucial heterodimeric partner for other EGFR family members and has the potential to regulate EGFR/HER2-mediated resistance...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29989022/post-transcriptional-regulation-of-micrornas-in-cancer-from-prediction-to-validation
#6
Sheril June Ankasha, Mohamad Nasir Shafiee, Norhazlina Abdul Wahab, Raja Affendi Raja Ali, Norfilza Mohd Mokhtar
MicroRNA (miRNA) is a small non-coding RNA with an established function to regulate genes at the post-transcriptional level leading to suppression or degradation of its messenger RNA expression (mRNA). Its dysregulation plays a vital role in a variety of biological and pathological processes including cancer. A lot of algorithms have been established to predict the target sites of miRNA, but experimentally identifying and validating its target region is still lacking. Guidance in experimental procedures is really needed to find genuine miRNA targets...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29983903/time-to-tame-necroptosis-viable-combat-against-chemo-resistant-oral-cancer-cells
#7
Samapika Routray
No abstract text is available yet for this article.
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29983902/the-role-of-pemetrexed-in-recurrent-epithelial-ovarian-cancer-a-scoping-review
#8
Michael Roche, Laura Parisi, Linda Li, Amy Knehans, Rebecca Phaeton, Joshua P Kesterson
Ovarian cancer is the leading cause of mortality among gynecologic malignancies, with most cases diagnosed at an advanced stage. Despite an initial response, most develop a recurrence and subsequent resistance to standard therapies. Pemetrexed (AlimtaTM ) is a new generation multi-targeted antifolate initially approved for the treatment of malignant pleural mesothelioma. In recent years, it has shown promise in the treatment of recurrent epithelial ovarian cancer. In this review, we outline the current literature and discuss the future of pemetrexed in the setting of recurrent epithelial ovarian cancer...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29774137/saudi-anti-human-cancer-plants-database-sacpd-a-collection-of-plants-with-anti-human-cancer-activities
#9
Ateeq Ahmed Al-Zahrani
Several anticancer drugs have been developed from natural products such as plants. Successful experiments in inhibiting the growth of human cancer cell lines using Saudi plants were published over the last three decades. Up to date, there is no Saudi anticancer plants database as a comprehensive source for the interesting data generated from these experiments. Therefore, there was a need for creating a database to collect, organize, search and retrieve such data. As a result, the current paper describes the generation of the Saudi anti-human cancer plants database (SACPD)...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29774136/the-impact-of-mir-9-regulation-in-normal-and-malignant-hematopoiesis
#10
Abbas Khosravi, Shaban Alizadeh, Arsalan Jalili, Reza Shirzad, Najmaldin Saki
MicroRNA-9 (MiR-9) dysregulation has been observed in various cancers. Recently, MiR-9 is considered to have a part in hematopoiesis and hematologic malignancies. However, its importance in blood neoplasms is not yet well defined. Thus, this study was conducted in order to assess the significance of MiR-9 role in the development of hematologic neoplasia, prognosis, and treatment approaches. We have shown that a large number of MiR-9 targets (such as FOXOs, SIRT1, CCND1, ID2, CCNG1, Ets, and NFkB) play essential roles in leukemogenesis and that it is overexpressed in different leukemias...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29441150/-punica-granatum-pomegranate-activity-in-health-promotion-and-cancer-prevention
#11
Shahindokht Bassiri-Jahromi
Cancer has become one of the most fatal diseases in most countries. In spite of the medical care developing, cancer still remains a significant problem. The majority of the cancers are resistant to treatment. Thus, the research for novel, more efficient and less side effect treatment methods continues. Pomegranate contains strong antioxidant activity, with potential health interests. Research concern in pomegranate is increasing because of their anticancer potential due to possess rich in polyphenols. We highlight the pomegranate potential health benefits and mechanism of cancer progression inhibition...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29285321/carcinogenesis-relevant-biological-events-in-the-pathophysiology-of-the-efferocytosis-phenomenon
#12
REVIEW
Gargi Sachin Sarode, Sachin C Sarode, Nikunj Maniyar, Nilesh Kumar Sharma, Shankargouda Patil
No abstract text is available yet for this article.
June 14, 2017: Oncology Reviews
https://www.readbyqxmd.com/read/28959380/povidone-iodine-for-the-management-of-oral-mucositis-during-cancer-therapy
#13
Jeeve Kanagalingam, Akhil Chopra, Min Hee Hong, Wisam Ibrahim, Antonio Villalon, Jin-Ching Lin
Oral mucositis (OM) is a common and often dose-limiting side effect of cancer therapy. Povidone iodine (PVP-I) formulations have been shown to decrease the incidence and severity of OM, but the relevance of these findings remains unclear. The objective of the present study was to review evidence for the use of PVP-I for OM management. An algorithm identified relevant articles published online, and a panel of experts with experience in the management of OM reviewed the findings. Six studies fulfilled the criteria for full review...
June 14, 2017: Oncology Reviews
https://www.readbyqxmd.com/read/28814999/centralization-of-liver-cancer-surgery-and-impact-on-multidisciplinary-teams-working-on-stage-iv-colorectal-cancer
#14
REVIEW
Elroy Patrick Weledji
Surgical resection is the most effective treatment approach for colorectal liver metastases but only a minority of patients is suitable for upfront surgery. The treatment strategies of stage IV colorectal cancer have shifted towards a continuum of care in which medical and surgical treatment combinations are tailored to the clinical setting of the individual patient. The optimization of treatment through appropriate decision-making and multimodal therapy for stage IV colorectal cancer require a joint multidisciplinary meeting in a centralized liver cancer unit...
June 14, 2017: Oncology Reviews
https://www.readbyqxmd.com/read/28781723/developing-a-comprehensive-cardio-oncology-program-at-a-cancer-institute-the-moffitt-cancer-center-experience
#15
REVIEW
Michael G Fradley, Allen C Brown, Bernadette Shields, Federico Viganego, Rongras Damrongwatanasuk, Aarti A Patel, Gregory Hartlage, Natalee Roper, Julie Jaunese, Larry Roy, Roohi Ismail-Khan
Cardio-oncology is a multidisciplinary field focusing on the management and prevention of cardiovascular complications in cancer patients and survivors. While the initial focus of this specialty was on heart failure associated with anthracycline use, novel anticancer agents are increasingly utilized and are associated with many other cardiotoxicities including hypertension, arrhythmias and vascular disease. Since its inception, the field has developed at a rapid pace with the establishment of programs at many major academic institutions and community practices...
June 14, 2017: Oncology Reviews
https://www.readbyqxmd.com/read/28680539/current-management-options-in-metastatic-renal-cell-cancer
#16
REVIEW
Sittu Govindasamy Dinakaran Gangadaran
Renal cancer accounts for 2.4% of all cancers. Localised disease accounts for the majority of renal cancers (70-75%), however 20-25% of these ultimately develop distant metastasis. The median overall survival of un treated metastatic disease is 5 months with 1-year survival of only 29%. The management of metastatic renal cell cancers traditionally relied on systemic immunotherapy with attendant high morbidity but after the year 2005 the use of effective targeted therapy with tolerable side effect profile has improved the survival from 10...
June 14, 2017: Oncology Reviews
https://www.readbyqxmd.com/read/28584572/journey-of-trail-from-bench-to-bedside-and-its-potential-role-in-immuno-oncology
#17
REVIEW
George E Naoum, Donald J Buchsbaum, Fady Tawadros, Ammad Farooqi, Waleed O Arafat
Induction of apoptosis in cancer cells has increasingly been the focus of many therapeutic approaches in oncology field. Since its identification as a TNF family member, TRAIL (TNF-related apoptosis-inducing ligand) paved a new path in apoptosis inducing cancer therapies. Its selective ability to activate extrinsic and intrinsic cell death pathways in cancer cells only, independently from p53 mutations responsible for conventional therapeutics resistance, spotted TRAIL as a potent cancer apoptotic agent. Many recombinant preparations of TRAIL and death receptor targeting monoclonal antibodies have been developed and being tested pre-clinically and clinically both as a single agent and in combinations...
March 3, 2017: Oncology Reviews
https://www.readbyqxmd.com/read/28584571/novel-strategies-to-improve-the-endocrine-therapy-of-breast-cancer
#18
REVIEW
Aurelio Bartolome Castrellon
Endocrine therapy (ET) constitutes the usual first-line of therapy for patients in the treatment of metastatic hormone receptor-positive breast cancer. Unfortunately, not all patients respond to first-line endocrine treatment due to intrinsic resistance, while others may initially respond but eventually progress with secondary acquired resistance leading to disease progression. Mechanisms of resistance to anti-estrogen therapy include, loss of expression for estrogen or progesterone receptor, upregulation of epidermal receptor growth factor 2, increased receptor tyrosine kinase signaling, leading to activation of various intracellular pathways that are involved in signal transduction such as PI3K/AKT/mammalian target of rapamycin, and others...
March 3, 2017: Oncology Reviews
https://www.readbyqxmd.com/read/28584570/bone-metastases-an-overview
#19
REVIEW
Filipa Macedo, Katia Ladeira, Filipa Pinho, Nadine Saraiva, Nuno Bonito, Luisa Pinto, Francisco Goncalves
Bone is a frequent site of metastases and typically indicates a short-term prognosis in cancer patients. Once cancer has spread to the bones it can rarely be cured, but often it can still be treated to slow its growth. The majority of skeletal metastases are due to breast and prostate cancer. Bone metastasis is actually much more common than primary bone cancers, especially in adults. The diagnosis is based on signs, symptoms and imaging. New classes of drugs and new interventions are given a better quality of life to these patients and improved the expectancy of life...
March 3, 2017: Oncology Reviews
https://www.readbyqxmd.com/read/28382191/chemotherapy-resistance-mechanisms-in-advanced-skin-cancer
#20
REVIEW
Bhuvanesh Sukhlal Kalal, Dinesh Upadhya, Vinitha Ramanath Pai
Melanoma is a most dangerous and deadly type of skin cancer, and considered intrinsically resistant to both radiotherapy and chemotherapy. It has become a major public health concern as the incidence of melanoma has been rising steadily over recent decades with a 5-year survival remaining less than 5%. Detection of the disease in early stage may be curable, but late stage metastatic disease that has spread to other organs has an extremely poor prognosis with a median survival of less than 10 months. Since metastatic melanoma is unresponsive to therapy that is currently available, research is now focused on different treatment strategies such as combinations of surgery, chemotherapy and radiotherapy...
March 3, 2017: Oncology Reviews
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