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Mobile DNA

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https://www.readbyqxmd.com/read/30100927/f-cphi-represents-a-new-homing-endonuclease-family-using-the-endo-vii-catalytic-motif
#1
Xiaoting Fang, YongLiang Jiang, Kim Li, Qinglu Zeng
Background: There are six known families of homing endonucleases, LAGLIDADG, GIY-YIG, HNH, His-Cys box, PD-(D/E)-XK, and EDxHD, which are characterized by their conserved residues. Previously, we discovered a novel homing endonuclease F-CphI encoded by ORF177 of cyanophage S-PM2. F-CphI does not resemble any characterized homing endonucleases. Instead, the C-terminus of F-CphI aligns well with the N-terminal catalytic domain of a Holliday junction DNA resolvase, phage T4 endonuclease VII (Endo VII)...
2018: Mobile DNA
https://www.readbyqxmd.com/read/30079119/srnapipe-a-galaxy-based-pipeline-for-bioinformatic-in-depth-exploration-of-small-rnaseq-data
#2
Romain Pogorelcnik, Chantal Vaury, Pierre Pouchin, Silke Jensen, Emilie Brasset
Background: The field of small RNA is one of the most investigated research areas since they were shown to regulate transposable elements and gene expression and play essential roles in fundamental biological processes. Small RNA deep sequencing (sRNA-seq) is now routinely used for large-scale analyses of small RNA. Such high-throughput sequencing typically produces several millions reads. Results: Here we present a computational pipeline (sRNAPipe: small RNA pipeline) based on the Galaxy framework that takes as input a fastq file of small RNA-seq reads and performs successive steps of mapping to categories of genomic sequences: transposable elements, gene transcripts, microRNAs, small nuclear RNAs, ribosomal RNAs and transfer RNAs...
2018: Mobile DNA
https://www.readbyqxmd.com/read/30026817/deletion-of-the-sex-determining-gene-sxi1%C3%AE-enhances-the-spread-of-mitochondrial-introns-in-cryptococcus-neoformans
#3
Zhun Yan, Zhimin Li, Li Yan, Yongting Yu, Yi Cheng, Jia Chen, Yunyun Liu, Chunsheng Gao, Liangbin Zeng, Xiangping Sun, Litao Guo, Jianping Xu
Background: Homing endonuclease genes (HEGs) are widely distributed genetic elements in the mitochondrial genomes of a diversity of eukaryotes. Due to their ability to self-propagate within and between genomes, these elements can spread rapidly in populations. Whether and how such elements are controlled in genomes remains largely unknown. Results: Here we report that the HEG-containing introns in the mitochondrial COX1 gene in Cryptococcus neoformans are mobile and that their spread in sexual crosses is influenced by mating type ( MAT ) α-specific homeodomain gene SXI1 α...
2018: Mobile DNA
https://www.readbyqxmd.com/read/30002736/-drosophila-parasitoid-wasps-bears-a-distinct-dna-transposon-profile
#4
Alexandre Freitas da Silva, Filipe Zimmer Dezordi, Elgion Lucio Silva Loreto, Gabriel Luz Wallau
Background: The majority of Eukaryotic genomes are composed of a small portion of stable (non-mobile) genes and a large fraction of parasitic mobile elements such as transposable elements and endogenous viruses: the Mobilome. Such important component of many genomes are normally underscored in genomic analysis and detailed characterized mobilomes only exists for model species. In this study, we used a combination of de novo and homology approaches to characterize the Mobilome of two non-model parasitoid wasp species...
2018: Mobile DNA
https://www.readbyqxmd.com/read/30002735/l1-retrotransposition-in-the-soma-a-field-jumping-ahead
#5
REVIEW
Geoffrey J Faulkner, Victor Billon
Retrotransposons are transposable elements (TEs) capable of "jumping" in germ, embryonic and tumor cells and, as is now clearly established, in the neuronal lineage. Mosaic TE insertions form part of a broader landscape of somatic genome variation and hold significant potential to generate phenotypic diversity, in the brain and elsewhere. At present, the LINE-1 (L1) retrotransposon family appears to be the most active autonomous TE in most mammals, based on experimental data obtained from disease-causing L1 mutations, engineered L1 reporter systems tested in cultured cells and transgenic rodents, and single-cell genomic analyses...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29946370/extensive-exchange-of-transposable-elements-in-the-drosophila-pseudoobscura-group
#6
Tom Hill, Andrea J Betancourt
Background: As species diverge, so does their transposable element (TE) content. Within a genome, TE families may eventually become dormant due to host-silencing mechanisms, natural selection and the accumulation of inactive copies. The transmission of active copies from a TE families, both vertically and horizontally between species, can allow TEs to escape inactivation if it occurs often enough, as it may allow TEs to temporarily escape silencing in a new host. Thus, the contribution of horizontal exchange to TE persistence has been of increasing interest...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29946369/unexpected-invasion-of-miniature-inverted-repeat-transposable-elements-in-viral-genomes
#7
Hua-Hao Zhang, Qiu-Zhong Zhou, Ping-Lan Wang, Xiao-Min Xiong, Andrea Luchetti, Didier Raoult, Anthony Levasseur, Sebastien Santini, Chantal Abergel, Matthieu Legendre, Jean-Michel Drezen, Catherine Béliveau, Michel Cusson, Shen-Hua Jiang, Hai-Ou Bao, Cheng Sun, Thomas E Bureau, Peng-Fei Cheng, Min-Jin Han, Ze Zhang, Xiao-Gu Zhang, Fang-Yin Dai
Background: Transposable elements (TEs) are common and often present with high copy numbers in cellular genomes. Unlike in cellular organisms, TEs were previously thought to be either rare or absent in viruses. Almost all reported TEs display only one or two copies per viral genome. In addition, the discovery of pandoraviruses with genomes up to 2.5-Mb emphasizes the need for biologists to rethink the fundamental nature of the relationship between viruses and cellular life. Results: Herein, we performed the first comprehensive analysis of miniature inverted-repeat transposable elements (MITEs) in the 5170 viral genomes for which sequences are currently available...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29942366/horizontal-transfer-and-proliferation-of-tsu4-in-saccharomyces-paradoxus
#8
Casey M Bergman
Background: Recent evidence suggests that horizontal transfer plays a significant role in the evolution of of transposable elements (TEs) in eukaryotes. Many cases of horizontal TE transfer (HTT) been reported in animals and plants, however surprisingly few examples of HTT have been reported in fungi. Findings: Here I report evidence for a novel HTT event in fungi involving Tsu4 in Saccharomyces paradoxus based on (i) unexpectedly high similarity between Tsu4 elements in S...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29942365/transposable-elements-and-gene-expression-during-the-evolution-of-amniotes
#9
Lu Zeng, Stephen M Pederson, R Daniel Kortschak, David L Adelson
Background: Transposable elements (TEs) are primarily responsible for the DNA losses and gains in genome sequences that occur over time within and between species. TEs themselves evolve, with clade specific LTR/ERV, LINEs and SINEs responsible for the bulk of species-specific genomic features. Because TEs can contain regulatory motifs, they can be exapted as regulators of gene expression. While TE insertions can provide evolutionary novelty for the regulation of gene expression, their overall impact on the evolution of gene expression is unclear...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29745378/correction-to-the-samhd1-mediated-block-of-line-1-retroelements-is-regulated-by-phosphorylation
#10
A Herrmann, S Wittmann, D Thomas, C N Shepard, B Kim, N Ferreirós, T Gramberg
[This corrects the article DOI: 10.1186/s13100-018-0116-5.].
2018: Mobile DNA
https://www.readbyqxmd.com/read/29743957/the-case-for-not-masking-away-repetitive-dna
#11
EDITORIAL
R Keith Slotkin
In the course of analyzing whole-genome data, it is common practice to mask or filter out repetitive regions of a genome, such as transposable elements and endogenous retroviruses, in order to focus only on genes and thus simplify the results. This Commentary is a plea from one member of the Mobile DNA community to all gene-centric researchers: please do not ignore the repetitive fraction of the genome . Please stop narrowing your findings by only analyzing a minority of the genome, and instead broaden your analyses to include the rich biology of repetitive and mobile DNA...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29713390/retrotransposon-targeting-to-rna-polymerase-iii-transcribed-genes
#12
REVIEW
Stephanie Cheung, Savrina Manhas, Vivien Measday
Retrotransposons are genetic elements that are similar in structure and life cycle to retroviruses by replicating via an RNA intermediate and inserting into a host genome. The Saccharomyces cerevisiae ( S. cerevisiae ) Ty1-5 elements are long terminal repeat (LTR) retrotransposons that are members of the Ty1- copia ( Pseudoviridae ) or Ty3- gypsy ( Metaviridae ) families. Four of the five S. cerevisiae Ty elements are inserted into the genome upstream of RNA Polymerase (Pol) III-transcribed genes such as transfer RNA (tRNA) genes...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29632618/a-computational-reconstruction-of-papio-phylogeny-using-alu-insertion-polymorphisms
#13
Vallmer E Jordan, Jerilyn A Walker, Thomas O Beckstrom, Cody J Steely, Cullen L McDaniel, Corey P St Romain, Kim C Worley, Jane Phillips-Conroy, Clifford J Jolly, Jeffrey Rogers, Miriam K Konkel, Mark A Batzer
Background: Since the completion of the human genome project, the diversity of genome sequencing data produced for non-human primates has increased exponentially. Papio baboons are well-established biological models for studying human biology and evolution. Despite substantial interest in the evolution of Papio , the systematics of these species has been widely debated, and the evolutionary history of Papio diversity is not fully understood. Alu elements are primate-specific transposable elements with a well-documented mutation/insertion mechanism and the capacity for resolving controversial phylogenetic relationships...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29610583/contrasted-patterns-of-evolution-of-the-line-1-retrotransposon-in-perissodactyls-the-history-of-a-line-1-extinction
#14
Akash Sookdeo, Crystal M Hepp, Stéphane Boissinot
Background: LINE-1 (L1) is the dominant autonomously replicating non-LTR retrotransposon in mammals. Although our knowledge of L1 evolution across the tree of life has considerably improved in recent years, what we know of L1 evolution in mammals is biased and comes mostly from studies in primates (mostly human) and rodents (mostly mouse). It is unclear if patterns of evolution that are shared between those two groups apply to other mammalian orders. Here we performed a detailed study on the evolution of L1 in perissodactyls by making use of the complete genome of the domestic horse and of the white rhinoceros...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29610582/the-samhd1-mediated-block-of-line-1-retroelements-is-regulated-by-phosphorylation
#15
Alexandra Herrmann, Sabine Wittmann, Dominique Thomas, Caitlin N Shepard, Baek Kim, Nerea Ferreirós, Thomas Gramberg
Background: The restriction factor SAMHD1 regulates intracellular nucleotide level by degrading dNTPs and blocks the replication of retroviruses and DNA viruses in non-cycling cells, like macrophages or dendritic cells. In patients, inactivating mutations in samhd1 are associated with the autoimmune disease Aicardi-Goutières Syndrome (AGS). The accumulation of intracellular nucleic acids derived from endogenous retroelements thriving in the absence of SAMHD1 has been discussed as potential trigger of the autoimmune reaction...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29560044/analysis-of-lineage-specific-alu-subfamilies-in-the-genome-of-the-olive-baboon-papio-anubis
#16
Cody J Steely, Jasmine N Baker, Jerilyn A Walker, Charles D Loupe, Mark A Batzer
Background: Alu elements are primate-specific retroposons that mobilize using the enzymatic machinery of L1 s. The recently completed baboon genome project found that the mobilization rate of Alu elements is higher than in the genome of any other primate studied thus far. However, the Alu subfamily structure present in and specific to baboons had not been examined yet. Results: Here we report 129 Alu subfamilies that are propagating in the genome of the olive baboon, with 127 of these subfamilies being new and specific to the baboon lineage...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29449901/recently-integrated-alu-insertions-in-the-squirrel-monkey-saimiri-lineage-and-application-for-population-analyses
#17
Jasmine N Baker, Jerilyn A Walker, Michael W Denham, Charles D Loupe, Mark A Batzer
Background: The evolution of Alu elements has been ongoing in primate lineages and Alu insertion polymorphisms are widely used in phylogenetic and population genetics studies. Alu subfamilies in the squirrel monkey ( Saimiri ), a New World Monkey (NWM), were recently reported. Squirrel monkeys are commonly used in biomedical research and often require species identification. The purpose of this study was two-fold: 1) Perform locus-specific PCR analyses on recently integrated Alu insertions in Saimiri to determine their amplification dynamics, and 2) Identify a subset of Alu insertion polymorphisms with species informative allele frequency distributions between the Saimiri sciureus and Saimiri boliviensis groups...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29445422/sleeping-beauty-transposon-integrates-into-non-ta-dinucleotides
#18
Yabin Guo, Yin Zhang, Kaishun Hu
Background: Sleeping Beauty transposon (SB) has become an increasingly important genetic tool for generating mutations in vertebrate cells. It is widely thought that SB exclusively integrates into TA dinucleotides. However, this strict TA-preference has not been rigorously tested in large numbers of insertion sites that now can be detected with next generation sequencing. Li et al. found 71 SB insertions in non-TA dinucleotides in 2013, suggesting that TA dinucleotides are not the only sites of SB integration, yet further studies on this topic have not been carried out...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29441132/association-of-zygotic-pirnas-derived-from-paternal-p-elements-with-hybrid-dysgenesis-in-drosophila-melanogaster
#19
Keiko Tsuji Wakisaka, Kenji Ichiyanagi, Seiko Ohno, Masanobu Itoh
Background: P -element transposition in the genome causes P-M hybrid dysgenesis in Drosophila melanogaster . Maternally deposited piRNAs suppress P -element transposition in the progeny, linking them to P-M phenotypes; however, the role of zygotic piRNAs derived from paternal P elements is poorly understood. Results: To elucidate the molecular basis of P -element suppression by zygotic factors, we investigated the genomic constitution and P -element piRNA production derived from fathers...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29422954/genetic-exchange-in-eukaryotes-through-horizontal-transfer-connected-by-the-mobilome
#20
REVIEW
Gabriel Luz Wallau, Cristina Vieira, Élgion Lúcio Silva Loreto
Background: All living species contain genetic information that was once shared by their common ancestor. DNA is being inherited through generations by vertical transmission (VT) from parents to offspring and from ancestor to descendant species. This process was considered the sole pathway by which biological entities exchange inheritable information. However, Horizontal Transfer (HT), the exchange of genetic information by other means than parents to offspring, was discovered in prokaryotes along with strong evidence showing that it is a very important process by which prokaryotes acquire new genes...
2018: Mobile DNA
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