journal
MENU ▼
Read by QxMD icon Read
search

Epigenomics

journal
https://www.readbyqxmd.com/read/28530839/meeting-report-of-the-fifth-international-cancer-epigenetics-conference-in-beijing-china-october-2016
#1
Dan Gao, James G Herman, Hengmi Cui, Jin Jen, Francois Fuks, Malcolm V Brock, Toshikazu Ushijima, Carlo Croce, Yoshimitsu Akiyama, Mingzhou Guo
Fifth International Cancer Epigenetics Conference, Beijing, China, 21-23 October 2016 This meeting reported many new findings in the field of cancer epigenetics, including basic science, translational and clinical studies. In this report, we summarize some of the main advancements and prospects in cancer epigenetics presented at this meeting.
May 22, 2017: Epigenomics
https://www.readbyqxmd.com/read/28523967/comparative-assessment-of-dna-methylation-patterns-between-reduced-representation-bisulfite-sequencing-and-sequenom-epityper-methylation-analysis
#2
Aniruddha Chatterjee, Erin C Macaulay, Antonio Ahn, Jackie L Ludgate, Peter A Stockwell, Rob J Weeks, Matthew F Parry, Timothy J Foster, Ingrid M Knarston, Michael R Eccles, Ian M Morison
AIM: Validation of sequencing-based DNA methylation data is an important step for meaningful translation of findings. However, there has been limited assessment of different platforms to validate methylation data from next generation sequencing. METHODS: We performed a comparative methylation analysis between the genome-wide platform of reduced representation bisulfite sequencing with a targeted, Sequenom EpiTyper platform (four genes were analyzed in 15 cell lines covering 52 CpG sites)...
May 19, 2017: Epigenomics
https://www.readbyqxmd.com/read/28523964/epigenetics-in-endometrial-carcinogenesis-part-2-histone-modifications-chromatin-remodeling-and-noncoding-rnas
#3
Carla Bartosch, José Manuel Lopes, Carmen Jerónimo
Carcinogenesis is a multistep multifactorial process that involves the accumulation of genetic and epigenetic alterations. In the past two decades, there has been an exponential growth of knowledge establishing the importance of epigenetic changes in cancer. Our work focused on reviewing the main role of epigenetics in the pathogenesis of endometrial carcinoma, highlighting the reported results concerning each epigenetic mechanistic layer. In a previous review, we assessed DNA methylation alterations. The present review examines the contribution of histone modifications, chromatin remodeling and noncoding RNA alterations for endometrial carcinogenesis...
May 19, 2017: Epigenomics
https://www.readbyqxmd.com/read/28523931/epigenetics-and-noncommunicable-diseases
#4
Gemma C Sharp, Caroline L Relton
No abstract text is available yet for this article.
May 19, 2017: Epigenomics
https://www.readbyqxmd.com/read/28521512/the-brg1-atpase-of-human-swi-snf-chromatin-remodeling-enzymes-as-a-driver-of-cancer
#5
Qiong Wu, Jane B Lian, Janet L Stein, Gary S Stein, Jeffrey A Nickerson, Anthony N Imbalzano
Mammalian SWI/SNF enzymes are ATP-dependent remodelers of chromatin structure. These multisubunit enzymes are heterogeneous in composition; there are two catalytic ATPase subunits, BRM and BRG1, that are mutually exclusive, and additional subunits are incorporated in a combinatorial manner. Recent findings indicate that approximately 20% of human cancers contain mutations in SWI/SNF enzyme subunits, leading to the conclusion that the enzyme subunits are critical tumor suppressors. However, overexpression of specific subunits without apparent mutation is emerging as an alternative mechanism by which cellular transformation may occur...
May 19, 2017: Epigenomics
https://www.readbyqxmd.com/read/28517961/overcoming-chemoresistance-in-cancer-stem-cells-with-the-help-of-micrornas-in-colorectal-cancer
#6
Andrew Fesler, Shixiang Guo, Hua Liu, Ning Wu, Jingfang Ju
It has been recognized that acute resistance to chemotherapy mediated by post-transcriptional and translational control is crucial to influence response and survival in cancer treatment. Tumor cells are highly heterogeneous and have the ability to adapt a resistance phenotype through epigenetic regulations such as microRNAs. This poses a major challenge to the treatment of advanced stage colon cancer patients. Colon cancer stem cells have been identified as one of the major contributors to resistance of colon cancer to chemotherapy...
May 18, 2017: Epigenomics
https://www.readbyqxmd.com/read/28517952/dna-methylation-and-transcription-onset-in-the-brain
#7
Renaud Massart, Matthew Suderman, Valerie Mongrain, Moshe Szyf
AIM: The goal of this study was to test the state of methylation of transcription start positions in DNA that are actively involved in transcription. MATERIALS & METHODS: We used sequential ChIP-bisulfite-sequencing with an antibody to RNpolII-PS5 to map the state of methylation of actively transcribing transcription start sites (TSS). RESULTS: TSS that RNApolII-PS5 physically bind to, are ubiquitously unmethylated. TSS that appear to be both heavily methylated and transcriptionally active are truly a mixture of unmethylated TSS with bound RNApolII-PS5 in some nuclei and unbound methylated TSS in other nuclei...
May 18, 2017: Epigenomics
https://www.readbyqxmd.com/read/28488887/rapid-and-affordable-genome-wide-bisulfite-dna-sequencing-by-xmai-reduced-representation-bisulfite-sequencing
#8
Alexander S Tanas, Marina E Borisova, Ekaterina B Kuznetsova, Viktoria V Rudenko, Kristina O Karandasheva, Marina V Nemtsova, Vera L Izhevskaya, Olga A Simonova, Sergey S Larin, Dmitry V Zaletaev, Vladimir V Strelnikov
AIM: To develop a reduced representation bisulfite sequencing (RRBS) approach for rapid and affordable genome-wide DNA methylation analysis. METHODS: We have selected restriction endonuclease XmaI to produce RRBS library fragments. After digestion and partial fill-in DNA fragments were ligated to barcoded adapters, bisulfite converted, size-selected, and sequenced on the Ion Torrent Personal Genome Machine. XmaI-RRBS results were compared with the previously published RRBS data...
May 10, 2017: Epigenomics
https://www.readbyqxmd.com/read/28470125/aging-exceptional-longevity-and-comparisons-of-the-hannum-and-horvath-epigenetic-clocks
#9
Nicola J Armstrong, Karen A Mather, Anbupalam Thalamuthu, Margaret J Wright, Julian N Trollor, David Ames, Henry Brodaty, Peter R Schofield, Perminder S Sachdev, John B Kwok
AIM: To examine the relationships between two epigenetic clocks, aging and exceptional longevity. MATERIALS & METHODS: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks. RESULTS: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28470118/changes-in-high-density-lipoprotein-carried-mirna-contribution-to-the-plasmatic-pool-after-consumption-of-dietary-trans-fat-in-healthy-men
#10
Véronique Desgagné, Renée Guérin, Simon-Pierre Guay, François Corbin, Patrick Couture, Benoit Lamarche, Luigi Bouchard
AIM: High-density lipoproteins (HDLs) are associated to cardioprotection and transport functional miRNAs in circulation. The aim of this study is to assess whether consumption of trans fatty acids (TFAs) modifies the HDL-carried miRNA concentration and their contribution to the plasmatic pool. METHODS: In a double-blind, randomized crossover controlled study, nine healthy men were fed each of three isoenergetic 4-week diets: first, rich in industrial TFAs; second, rich in TFAs from ruminants; third, low in TFAs...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28470099/understanding-epigenetics-of-schizophrenia-in-the-backdrop-of-its-antipsychotic-drug-therapy
#11
Babu Swathy, Moinak Banerjee
The diatheses of gene and environment interaction in schizophrenia (SCZ) are becoming increasingly evident. Genetic and epigenetic backgrounds are being considered in stratifying and addressing phenotypic variation and drug response in SCZ. But how much of these epigenetic alterations are the primary contributing factor, toward disease pathogenesis and drug response, needs further clarity. Evidence indicates that antipsychotic drugs can also alter the epigenetic homeostasis thereby inducing pharmacoepigenomic effects...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28470097/phenylbutyrate-and-%C3%AE-cell-function-contribution-of-histone-deacetylases-and-er-stress-inhibition
#12
Sabbir Khan, Sandeep K Komarya, Gopabandhu Jena
Incidences of diabetes are increasing globally due to involvement of genetic and epigenetic factors. Phenylbutyrate (PBA) is a US FDA approved drug for treatment of urea cycle disorder in children. PBA reduces endoplasmic reticulum (ER) stress and is proven as a potent histone deacetylases (HDACs) inhibitor. Chronic ER stress results in unfolding protein response, which triggers apoptosis. Abnormal ER homoeostasis is responsible for defective processing of several genes/proteins and contributes to β-cell death/failure...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28470096/epigenetics-in-endometrial-carcinogenesis-part-1-dna-methylation
#13
Carla Bartosch, José Manuel Lopes, Carmen Jerónimo
Carcinogenesis is a multistep multifactorial process that involves the accumulation of genetic and epigenetic alterations. In the past two decades, there has been an exponential growth of knowledge establishing the importance of epigenetic changes in cancer. Our work focused on reviewing the main role of epigenetics in the pathogenesis of endometrial carcinoma, highlighting the reported results concerning each epigenetic mechanistic layer. The present review is the first part of this work, in which we examined the contribution of DNA methylation alterations for endometrial carcinogenesis...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28470095/impact-of-confounding-by-leukocyte-composition-on-associations-of-leukocyte-dna-methylation-with-common-risk-factors
#14
Jonathan Alexander Heiss, Hermann Brenner
AIM: One concern in epigenome-wide studies investigating leukocyte DNA methylation is that observed associations may at least partly reflect differences in leukocyte composition (LC) rather than changes in methylation. We estimated the magnitude of confounding by LC for common risk factors and diseases. MATERIALS & METHODS: Variation of LC according to sex, race, age, smoking, alcohol consumption, BMI, cardiovascular fitness, hypertension, coronary heart disease and diabetes was analyzed using blood differentials from 4117 participants of NHANES...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28470094/dna-methylation-controls-unmethylated-transcription-start-sites-in-the-genome-in-trans
#15
David Cheishvili, Steffan Christiansen, Rebecca Stochinsky, Anne-Sophie Pepin, Daniel M Sapozhnikov, Rudy Zhou, Lauren Schmeltzer, Sergey Dymov, Moshe Szyf
AIM: DNA methylation downregulates transcription. However, a large number of genes, which are unmethylated in the promoter region, are inactive. We tested the hypothesis that these genes are regulated by DNA methylation of upstream regulators. METHODS: We inhibited DNMT1 with 5-aza-2'-deoxycytidine or depleted it with shRNA to map the transcription initiation positions controlled by DNMT1 using ChIPseq with RNApolIIser5 antibody. Ingenuity pathway analysis identified potential methylated upstream regulators...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28470093/genetic-and-epigenetic-mechanisms-underlying-arsenic-associated-diabetes-mellitus-a-perspective-of-the-current-evidence
#16
Elizabeth M Martin, Miroslav Stýblo, Rebecca C Fry
Chronic exposure to arsenic has been associated with the development of diabetes mellitus (DM), a disease characterized by hyperglycemia resulting from dysregulation of glucose homeostasis. This review summarizes four major mechanisms by which arsenic induces diabetes, namely inhibition of insulin-dependent glucose uptake, pancreatic β-cell damage, pancreatic β-cell dysfunction and stimulation of liver gluconeogenesis that are supported by both in vivo and in vitro studies. Additionally, the role of polymorphic variants associated with arsenic toxicity and disease susceptibility, as well as epigenetic modifications associated with arsenic exposure, are considered in the context of arsenic-associated DM...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28470092/the-sept9-gene-methylation-assay-is-capable-of-detecting-colorectal-adenoma-in-opportunistic-screening
#17
Lele Song, Xiumei Peng, Yuemin Li, Wenhua Xiao, Jia Jia, Cheng Dong, Yuan Gong, Guangpeng Zhou, Xiaoliang Han
AIM: This study validated the detection of colorectal adenoma in opportunistic screening using the SEPT9 gene methylation assay. MATERIALS & METHODS: Plasma samples including 85 colorectal cancers, 364 adenomas, 216 hyperplastic polyps, 372 other gastrointestinal diseases and 324 normal subjects, were obtained and tested using the Epi proColon 2.0 CE assay. RESULTS & CONCLUSION: The SEPT9 assay detected 38.7% of all types of adenoma, including 27...
May 4, 2017: Epigenomics
https://www.readbyqxmd.com/read/28447857/cpg-specific-methylation-at-rheumatoid-arthritis-diagnosis-as-a-marker-of-treatment-response
#18
Steven Horsburgh, Marzena Ciechomska, Steven O'Reilly
No abstract text is available yet for this article.
April 27, 2017: Epigenomics
https://www.readbyqxmd.com/read/28429622/pharmacoepigenomic-responses-of-antipsychotic-drugs-on-pharmacogenes-are-likely-to-be-modulated-by-mirnas
#19
Babu Swathy, Koramannil R Saradalekshmi, Indu V Nair, Chandrasekharan Nair, Moinak Banerjee
AIM: It is imperative to differentiate the role of host epigenetics from pharmacoepigenetics in resolving therapeutic response. Therefore, the objective was to identify how antipsychotic drugs influence epigenetic response on pharmacogenes. MATERIALS & METHODS: The study design was based on in vitro evaluation of pharmacoepigenetic response of haloperidol, clozapine and olanzapine. Post antipsychotic treatment, the alterations in expression of ABCB1, CYP1A2 and CYP3A4 were monitored, and followed up by promoter methylation and their target miRNA expression studies...
April 21, 2017: Epigenomics
https://www.readbyqxmd.com/read/28403629/methylation-of-slfn11-is-a-marker-of-poor-prognosis-and-cisplatin-resistance-in-colorectal-cancer
#20
Tao He, Meiying Zhang, Ruipan Zheng, Shufang Zheng, Enqiang Linghu, James G Herman, Mingzhou Guo
AIM: The expression of human SLFN11 was reported to sensitize cancer cells to DNA damaging agents. This study is to explore the epigenetic change and the function of SLFN11 in human colorectal cancer (CRC). MATERIALS & METHODS: Six CRC cell lines and 128 primary CRC samples were used. RESULTS: SLFN11 was methylated in 55.47% (71/128) of primary CRC. The expression of SLFN11 was regulated by promoter region methylation. Methylation of SLFN11 was significantly associated with age, poor 5-year overall survival and 5-year relapse-free survival (all p < 0...
April 13, 2017: Epigenomics
journal
journal
42738
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"