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Journal of Clinical Research in Pediatric Endocrinology

Meda Kondolot, Duygu Horoz, Serpil Poyrazoğlu, Arda Borlu, Ahmet Öztürk, Selim Kurtoğlu, Mümtaz M Mazicioğlu
OBJECTIVE: Limited information is available about the use of neck circumference (NC) to determine the obesity in preschool children. This study aims to provide NC percentiles and determine the cut-off levels of NC as an additional measurement for obesity in preschool children. METHODS: The data was obtained from the Anthropometry of Turkish Children aged 0-6 years (ATCA-06) study database. A total of 21 Family Health Centers were chosen and children aged 2-6 years old were randomly selected according to the socioeconomic level from the list of district midwives...
September 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
Murat Kocyigit, Taliye Cakabay, Safiye G Ortekin, Teoman Akcay, Guven Ozkaya, Selin Ustun Bezgin, Melek Yildiz, Mustafa Kemal Adali
OBJECTIVE: Otitis media with effusion (OME) is a condition in which fluid is retained in the middle ear cavity, but without otalgia, fever, and other symptoms. The incidence of endocrinological disorders has been increasing, but the association between endocrinological disorders and OME has not yet been determined. In this study, it was aimed to investigate the presence of OME in children diagnosed with an endocrinological disease and their relationship with each other. METHODS: Our study was done with 918 children patients (440 boys, 478 girls; mean age: 8...
September 9, 2016: Journal of Clinical Research in Pediatric Endocrinology
Xueying Su, Ruizhu Lin, Yonglan Huang, Huiying Sheng, Xiaofei Li, Tzer Hwu Ting, Li Liu, Xiuzhen Li
OBJECTIVE: To investigate the clinical and molecular features of three Chinese patients with various typical manifestations of congenital generalized lipodystrophy (CGL). METHODS: Clinical symptoms, results of laboratory analyses, and data on previous treatments in three Chinese patients were collected by retrospective review of medical records. All coding regions and adjacent exon-intron junction regions of AGPAT2 and BSCL2 genes were amplified by polymerase chain reaction and sequenced...
September 9, 2016: Journal of Clinical Research in Pediatric Endocrinology
Erdoğan Özgür, Börte Gürbüz Özgür, Hatice Aksu, Gökhan Cesur
OBJECTIVE: The aim of this study was to investigate the depression-like behaviors of juvenile rats with congenital and postnatal hypothyroidism. METHODS: Twenty seven newborn rat pups were used. First, 6-month old Wistar Albino female rats were impregnated. Methimazole (0.025% wt/vol) was given to dam rats from the first day of pregnancy until postnatal 21 days (P21) to generate pups with congenital hypothyroidism (n=8), whereas in the postnatal hypothyroidism group (n=10) methimazole was given from P0 to P21...
September 9, 2016: Journal of Clinical Research in Pediatric Endocrinology
Mostafa Mazloum Farsi Baf, Mozhgan Mazloum Farsi Baf, Fatemeh Noorollahi, Morteza Mazloum Farsi Baf
OBJECTIVE: Congenital hypothyroidism (CH) is one of the most common treatable causes of mental retardation and neurodevelopmental impairment. METHODS: In a cross-sectional study, 114342 neonates born in 28 cities in Razavi Khorasan province, northeastern Iran from Aril 2013 to March 2014, were screened for congenital hypothyroidism by taking blood sample from heel prick. The newborns with TSH ≥5 mIU/L were recalled for further assessment of TSH concentration in serum sample...
September 9, 2016: Journal of Clinical Research in Pediatric Endocrinology
Maria Dahl, Johanne Dam Ohrt, Cilius Esmann Fonvig, Julie Tonsgaard Kloppenborg, Oluf Pedersen, Torben Hansen, Jens Christian Holm
OBJECTIVE: Thyroid abnormalities are common in obese children. The aim of the present study was to examine the prevalence of subclinical hypothyroidism (SH) and to determine how circulating thyroid hormone concentrations correlate with anthropometrics in Danish lean and obese children and adolescents. METHODS: We included 3,006 children and adolescents, aged 6-18 years, from the Registry of the Danish Childhood Obesity Biobank in this cross-sectional study. The overweight/obese group (n=1,796) consisted of study participants with a body mass index (BMI) standard deviation score (SDS) ≥1...
September 9, 2016: Journal of Clinical Research in Pediatric Endocrinology
Mehmet Boyraz, Ediz Yeşilkaya, Fatih Ezgü, Aysun Bideci, Haldun Doğan, Korkut Ulucan, Peyami Cinaz
OBJECTIVE: Although polymorphisms in suppressor of cytokine signaling 3 (SOCS3) was reported to be related to obesity, metabolic syndrome and type 2 diabetes in various adult studies, there is a lack of data in children. In this study, we examined eight reported polymorphisms of SOCS3 in obese Turkish children with and without metabolic syndrome and compared the results with that of controls. METHODS: 148 obese and 63 age and sex matched control children were enrolled in the study...
September 9, 2016: Journal of Clinical Research in Pediatric Endocrinology
Daipayan Chatterjee, Mathad Ks Swamy, Vikas Gupta, Vasu Sharma, Akshat Sharma, Krishti Chatterjee
OBJECTIVE: Introduction: Stosstherapy has been used since early 19th century for treating nutritional rickets. However there are no clear cut guidelines for biochemical monitoring of treatment. Repeated blood tests at short intervals increases cost of therapy and noncompliance. METHODS: A prospective study was conducted on 191 cases of nutritional rickets below 10 years of age to evaluate the effectivity of Stosstherapy. They were treated with a single intramuscular injection of Vitamin-D (600000 IU) along with oral calcium (50 mg /kg) and vitamin D (400 IU per day) until radiological resolution...
August 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
E A Gorter, W Oostdijk, A Felius, P Krijnen, I B Schipper
OBJECTIVE: Although vitamin D levels are not routinely monitored in pediatric fracture patients, identification of children with a vitamin D deficiency may be clinically relevant because of the potential role of vitamin D in fracture healing. This study aimed to determine the prevalence of vitamin D deficiency in a pediatric fracture population and to identify risk factors for deficiency. METHODS: In this cross-sectional study all pediatric patients (<18 years), who were treated for a fracture of the upper or lower extremity from September 2012 to October 2013 in the outpatient setting of a level one trauma center, were included...
August 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
Gökmen Zararsız, Betül Çiçek, Meda Kondolot, M Mümtaz Mazıcıoğlu, Ahmet Öztürk, Selim Kurtoğlu
OBJECTIVE: We aimed to compare updated weight and height percentiles of 6-17 year-old children in Kayseri with the previous local references and some other national and international data. METHODS: The second study "Determination of Anthropometric Measurements of Turkish Children and Adolescents study (DAMTCA II)" was conducted in Kayseri, between October 2007 and April 2008. Weight and height measurements from 4.321 (1.926 boys, 2.395 girls) school children (aged between 6 to 17 years) from all socioeconomic levels were included in this cross-sectional study...
August 10, 2016: Journal of Clinical Research in Pediatric Endocrinology
Adnan M Al Shaikh, Bahaa Abaalkhail, Ashraf Soliman, Ibrahim Kaddam, Khalid Aseri, Yousef Al Saleh, Ali Al Qarni, Ahmed Al Shuaibi, Waleed Al Tamimi, Abdel Moniem Mukhtar
OBJECTIVE: Vitamin D deficiency (VDD) and insufficiency (VDI) are significant health problem all-over the world. The aim of this study was to determine the prevalence of VDD and VDI in children and adolescents residing in 8 provinces in the Kingdom of Saudi Arabia (KSA) and to investigate their calcium homeostasis. METHODS: A cross-sectional study with 2110 participants aged between 6 and 15 years were enrolled. The questionnaire included personal and socio-demographic, anthropometric measurements, knowledge about vitamin D, color of the skin, dietary intake, sun exposure experience, smoking, and physical activity...
July 30, 2016: Journal of Clinical Research in Pediatric Endocrinology
Ayla Güven, Seher Polat
OBJECTIVE: Testicular adrenal rest tumors (TART) have been frequently shown in adolescents and adults with 21-hydroxylase deficiency. There have been no reports of TART in children with 3β-hydroxysteroid dehydrogenase deficiency (HSD3β. METHODS: Biopsy proven TART was found at 31/12 years old in older brother while TART determined at 22 moths old in younger by USG. Hormonal and anthropometric measurements were performed during glucocorticoid and fludrocortisone treatment...
July 29, 2016: Journal of Clinical Research in Pediatric Endocrinology
Fatih Gürbüz, Serdar Ceylaner, Ali Kemal Topaloğlu, Bilgin Yüksel
No abstract text is available yet for this article.
September 1, 2016: Journal of Clinical Research in Pediatric Endocrinology
Duygu Övünç Hacıhamdioğlu, Demet Altun, Bülent Hacıhamdioğlu, Ferhat Çekmez, Gökhan Aydemir, Mustafa Kul, Tuba Müftüoğlu, Selami Süleymanoğlu, Ferhan Karademir
OBJECTIVE: Cathelicidin is an important antimicrobial peptide in the urinary tract. Cathelicidin expression is strongly stimulated by 1,25-dihydroxy vitamin D in epithelial cells, macrophages/monocytes, and neutrophils. Vitamin D and cathelicidin status in children with urinary tract infection (UTI) caused by Escherichia coli is unknown. To establish the relationship between serum vitamin D and urine cathelicidin levels in children with a UTI caused by Escherichia coli. METHODS: Serum 25-hydroxy vitamin D and urine cathelicidin levels were measured in 36 patients with UTI (mean age 6...
September 1, 2016: Journal of Clinical Research in Pediatric Endocrinology
Aylin Yetim, Çağcıl Yetim, Firdevs Baş, Oğuz Bülent Erol, Gülnaz Çığ, Ahmet Uçar, Feyza Darendeliler
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a common endocrine problem in adolescents with an increasing prevalence of 30%. Pursuing new biomarkers with high specificity and sensitivity in the diagnosis of PCOS in adolescents is currently an active area of research. We aimed to investigate the diagnostic value of anti-Müllerian hormone (AMH), insulin-like peptide-3 (INSL3), inhibin-A (INH-A), and inhibin-B (INH-B) in adolescents with PCOS and also to determine the association, if any, between these hormones and clinical/laboratory findings related with hyperandrogenism...
September 1, 2016: Journal of Clinical Research in Pediatric Endocrinology
Zeynep Şıklar, Mikayir Genens, Şükran Poyrazoğlu, Firdevs Baş, Feyza Darendeliler, Rüveyde Bundak, Zehra Aycan, Şenay Savaş Erdeve, Semra Çetinkaya, Ayla Güven, Saygın Abalı, Zeynep Atay, Serap Turan, Cengiz Kara, Gülay Can Yılmaz, Nesibe Akyürek, Ayhan Abacı, Gamze Çelmeli, Erkan Sarı, Semih Bolu, Hüseyin Anıl Korkmaz, Enver Şimşek, Gönül Çatlı, Muammer Büyükinan, Atilla Çayır, Olcay Evliyaoğlu, Pınar İşgüven, Tolga Özgen, Nihal Hatipoğlu, Atilla Halil Elhan, Merih Berberoğlu
OBJECTIVE: Noonan syndrome (NS) is a multisystem disorder, and short stature is its most striking manifestation. Optimal growth hormone (GH) treatment for NS is still controversial. In this study, using a nationwide registration system, we aimed to evaluate the growth characteristics and the clinical features of NS patients in Turkey and their growth response to GH treatment. METHODS: Children and adolescents with a diagnosis of NS were included inthe study. Laboratory assessment including standard GH stimulation test results were evaluated...
September 1, 2016: Journal of Clinical Research in Pediatric Endocrinology
Ala Üstyol, Mehmet Emre Atabek, Norman Taylor, Matthew Chun-Wing Yeung, Angel O K Chan
Isolated aldosterone synthase deficiency may result in life-threatening salt-wasting and failure to thrive. The condition involves hyperkalemia accompanying hyponatremia. Two types of aldosterone synthase deficiency may be observed depending on hormone levels: corticosterone methyl oxidase type 1 (CMO 1) and CMO 2. Herein, we describe a Turkish infant patient with aldosterone synthase deficiency who presented with failure to thrive and salt wasting but with normal potassium levels. Urinary steroid characteristics were compatible with CMO I deficiency...
September 1, 2016: Journal of Clinical Research in Pediatric Endocrinology
Atalay Demirel, Asuman Çoban, Şükran Yıldırım, Canan Doğan, Rukiye Sancı, Zeynep İnce
OBJECTIVE: To determine exposure to endocrine-disrupting phthalates in preterm infants in neonatal intensive care units (NICU). METHODS: Urine samples (n=151) from 36 preterm infants (<32 weeks of gestation and/or <1500 g of birth weight) were collected on the first 3 days of admission to the NICU and biweekly thereafter. Diethylhexyl phthalate contents of indwelling medical devices used in various procedures and the concentrations of phthalate metabolites in the urine samples were analyzed...
September 1, 2016: Journal of Clinical Research in Pediatric Endocrinology
Hamdi Cihan Emeksiz, Aysun Bideci, Çağrı Damar, Betül Derinkuyu, Nurullah Çelik, Esra Döğer, Özge Yüce, Mehmet Cüneyt Özmen, Mahmut Orhun Çamurdan, Peyami Cinaz
OBJECTIVE: Soluble endoglin (S-endoglin) has been implicated as a potential marker of endothelial dysfunction (ED) and was reported to be elevated in diabetic adults, correlating with the severity of diabetic vasculopathy. However, circulating S-endoglin and its association with other markers of ED have not been formerly analyzed in the first decade of diabetes onset in adolescents with type 1 diabetes mellitus (T1DM). METHODS: Fifty-eight adolescents with moderately/poorly controlled T1DM were included in this study and twenty-nine healthy adolescents served as controls...
September 1, 2016: Journal of Clinical Research in Pediatric Endocrinology
Gülcan Seymen Karabulut, Şükrü Hatun, Aysun Bideci, Enver Hasanoğlu
To determine the adherence of pediatricians to the nationwide 'Vitamin D Prophylaxis Program' and to evaluate their attitudes about vitamin D intake. The study was conducted using the Turkish National Pediatrics Association network. The pediatricians were asked to respond to an online questionnaire that included five questions on 'What dose of vitamin D they recommend for supplementation?', 'At what age they start vitamin D supplementation?', 'Supplementation method', 'Clichés and truths about vitamin D', and 'High-dose vitamin D therapy indications'...
September 1, 2016: Journal of Clinical Research in Pediatric Endocrinology
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