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International Journal of Analytical Chemistry

Naser F Al-Tannak, Ahmed Hemdan, Maya S Eissa
A rapid and selective UPLC-DAD method was developed and validated for simultaneous analysis of the novel two-drug combination Darvoni ® for the treatment of HCV: Sofosbuvir (SF)/Daclatasvir (DC) in human plasma using Ledipasvir as internal standard (IS) where the extraction process was conducted using automated SPE. Although the analysis of the combination after concomitant oral intake of two tablets of SF and DC individually was reported in literature, yet simultaneous analysis of this new combination in human plasma after a single oral dose was not previously reported...
2018: International Journal of Analytical Chemistry
Karen C Bedin, Edson Y Mitsuyasu, Amanda Ronix, André L Cazetta, Osvaldo Pezoti, Vitor C Almeida
The present work reports the development and application of bismuth-film electrode (BiFE), obtained by in situ method on the pencil-lead graphite surface, for simultaneous Cd(II) and Pb(II) determination at trace levels, as alternative to replace the mercury-film electrodes. Experimental factors, deposition time ( t d ), deposition potential ( E d ), and Bi(III) concentration ( C Bi ), were investigated by applying a 23 factorial design using 0.10 mol/L acetate buffer solution (pH 4.5) as supporting electrolyte...
2018: International Journal of Analytical Chemistry
Mohamed E I Badawy, Mahmoud A M El-Nouby, Abd El-Salam M Marei
The present study aims to prepare two new types of chitosan-metal oxide nanoparticles (Ch-MO NPs), namely, chitosan-copper oxide nanoparticles (Ch-CuO NPs) and chitosan-zinc oxide nanoparticles (Ch-ZnO NPs), using sol-gel precipitation mechanism, and test them new as adsorbent materials for extraction and clean-up of different pesticides from water. The design of core-shell was implemented by metal oxide core with chitosan as a hard shell after crosslinking mechanism by glutaraldehyde and then epichlorohydrin...
2018: International Journal of Analytical Chemistry
Claudia Invernizzi, Tommaso Rovetta, Maurizio Licchelli, Marco Malagodi
This study presents mid and near-infrared (7500-375 cm-1 ) total reflection mode spectra of several natural organic materials used in artworks as binding media, consolidants, adhesives, or protective coatings. A novel approach to describe and interpret reflectance bands as well as calculated absorbance after Kramers-Kronig transformation (KKT) is proposed. Transflection mode spectra have represented a valuable support both to study the distorted reflectance bands and to validate the applicability and usefulness of the KK correction...
2018: International Journal of Analytical Chemistry
Shibao Lu, Yan Wang, Liang Pei, Wei Li
This paper studies transmission behavior of La (III) in dispersed supported liquid membrane (DSLM) of dispersed phase constituted by dispersed supported liquid membrane solution and HCl solution with polyvinylidene fluoride membrane (PVDF) as support and kerosene as membrane solvent, with 2-ethyl hexyl phosphonic acid-single-2-ethyl hexyl ester (PC-88A) and two-(2-ethyl hexyl) phosphoric acid (D2EHPA) as mobile carrier. It also investigates the influence of La (III) transmission by the material liquid acidity, initial concentration of La (III), HCI concentration, membrane solution, and HCI solution volume ratio, resolving agent and carrier concentration, as well as concluding that the optimal transmission and separation conditions are dispersed phase of 4...
2018: International Journal of Analytical Chemistry
Marissa E Morales-Rodriguez, Joanna McFarlane, Michelle K Kidder
We describe a new approach for high sensitivity and real-time online measurements to monitor the kinetics in the processing of nuclear materials and other chemical reactions. Mid infrared (Mid-IR) quantum cascade laser (QCL) high-resolution spectroscopy was used for rapid and continuous sampling of nitrates in aqueous and organic reactive systems, using pattern recognition analysis and high sensitivity to detect and identify chemical species. In this standoff or off-set method, the collection of a sample for analysis is not required...
2018: International Journal of Analytical Chemistry
Tong Chen, Xinyu Chen, Daoli Lu, Bin Chen
The aim of the present study was to detect adulteration of canola oil with other vegetable oils such as sunflower, soybean, and peanut oils and to build models for predicting the content of adulterant oil in canola oil. In this work, 147 adulterated samples were detected by gas chromatography-ion mobility spectrometry (GC-IMS) and chemometric analysis, and two methods of feature extraction, histogram of oriented gradient (HOG) and multiway principal component analysis (MPCA), were combined to pretreat the data set...
2018: International Journal of Analytical Chemistry
Yonghong Zhong, Kejian Huang, Qiulian Luo, Suzhi Yao, Xiaofeng Liu, Ning Yang, Cuiwu Lin, Xuan Luo
A desktop NMR spectrometer was used to qualitatively analyze samples in drug-related cases in order to enhance the accuracy of the results and identify new drugs. Twelve known drugs and their derivatives were used to establish the parameters, conditions, and procedures for the methods and validate the feasibility and reliability of the methods. First, 1-D and 2-D NMR data for these 12 drugs and their derivatives were obtained in detail using a 600-MHz NMR spectrometer to create a data library. Next, some of these 12 drugs were analyzed using a Picospin 80 MHz desktop NMR spectrometer to set up the analytical procedure and method...
2018: International Journal of Analytical Chemistry
Guodong He, Liping Mai, Xipei Wang
Background: Both cis - and trans -cefprozil have antimicrobial activity, but their potencies are quite different. It is therefore necessary to develop a sensitive method to simultaneously determine both isomers for pharmacokinetic and bioequivalence studies. Methods: An LC-MS/MS method, using stable isotope-labeled cefprozil as the internal standard, was developed and validated. The analytes were extracted from plasma by protein precipitation and separated on a reverse-phase C18 column using a gradient program consisting of 0...
2018: International Journal of Analytical Chemistry
Hurmus Refiker, Melek Merdivan, Ruveyde Sezer Aygun
A simple and selective method has been developed for preconcentration of gold in ore samples. The method is based on use of N, N-diethyl-N'-benzoylthiourea (DEBT) as selective chelating agent and Amberlite XAD-16 as solid sorbent. Sorption behavior of gold with DEBT impregnated resin under optimized conditions has been studied in batch process. The gold ion capacity of the impregnated resin is calculated as 33.48 mg g-1 resin (0.17 mmol g-1 resin). The selective preconcentration of metal was examined using gold chelates prepared in column process under optimized conditions: pH, flow rate, volume of sample solution, nature of eluent, flow rate, and volume of eluent...
2018: International Journal of Analytical Chemistry
Nathan W Bower, Murphy G Brasuel, Eli Fahrenkrug, Matthew D Cooney
Croton megalocarpus seedcake oils from 30 different locations in south central Kenya were analyzed for their fatty acid composition using ATR-FTIR to determine the efficacy of a simple procedure for measuring initial geographic and subsequent temporal variation during five months of seed storage. To our knowledge, this is the first report showing variation in how oils in untreated nuts from different locations change during storage, and how these differences are correlated with local environments. These variations are important to forensic authentication efforts and they provide insights into ways to optimize Croton oil composition...
2018: International Journal of Analytical Chemistry
Young Hye Hahm, Sung Ho Hahm, Hyoun Young Jo, Yeong Hee Ahn
Glycosylation is one of the most important posttranslational modifications for proteins, including therapeutic antibodies, and greatly influences protein physiochemical properties. In this study, glycopeptide mapping of a reference and biosimilar recombinant antibodies (rAbs) was performed using liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) and an automated Glycoproteome Analyzer (GPA) algorithm. The tandem mass analyses for the reference and biosimilar samples indicate that this approach proves to be highly efficient in reproducing consistent analytical results and discovering the implications of different rAb production methods on glycosylation patterns...
2018: International Journal of Analytical Chemistry
Abderrezak Khelfi, Mohammed Azzouz, Rania Abtroun, Mohammed Reggabi, Berkahoum Alamir
Background and Objective: In this study, turbo-ion spray as an interface of tandem mass spectrometry (MS/MS) was performed for sensitive and accurate quantification of chlorpromazine, haloperidol, levomepromazine, olanzapine, risperidone, and sulpiride in plasma samples. Methods: Separation was performed by gradient reversed phase high-performance liquid chromatography using a mobile phase containing ammonium formiate 2 mM, pH 2.7, and acetonitrile flowing through a Restek PFP Propyl C18 analytical column (50 mm×2...
2018: International Journal of Analytical Chemistry
Qingxin Liu, Jialong Fan, Chuang Zhou, Liqun Wang, Bin Zhao, Haibin Zhang, Bin Liu, Chunyi Tong
As a new tumor marker, the microRNA-21 (miRNA21) level can provide important information for early diagnosis, drug treatment, and prognosis of gastric cancer. With the tool of molecular beacons which can hybridize specifically with target miRNA-21 and generate fluorescence signal change, this paper develops a direct, simple, and rapid method for miRNA-21 detection with detection limit of 0.5 nM. Under the optimal conditions, the method was used to detect the expression of miRNA-21 in tumor cells and tissues...
2018: International Journal of Analytical Chemistry
Mohd Aftab Alam, Fahad Ibrahim Al-Jenoobi, Abdullah Mohammed Al-Mohizea
Quick and specific bioanalytical methods are required for analyzing drugs in biological samples. A simple, quick, sensitive, and specific UPLC-MS/MS method was developed and validated for glibenclamide determination in plasma samples. The plasma samples were processed by protein precipitation technique. Glimepiride was used as internal standard (IS). Glibenclamide and glimepiride were eluted on C18 column (Acquity UPLC®BEH). Mobile phase consisting of acetonitrile (0.1% formic acid) and water (0.1% formic acid) was pumped in binary gradient mode at flow rate of 150 μ L/min...
2018: International Journal of Analytical Chemistry
Danijela Vidic, Amira Čopra-Janićijević, Mladen Miloš, Milka Maksimović
In order to determine influence of extraction method on volatile oil composition of Artemisia annua L., steam distillation, hydrodistillation, organic solvent extraction, and headspace sampling have been applied. The relative abundance of volatile compounds from the odorous aerial parts of A. annua , obtained by different extraction techniques, was analyzed by GC-MS. Exactly fifty constituents were identified. The leaf and flower essential oil yield ranged from 0.9 to 2.3% (v/w). Oxygenated monoterpenes were predominant in all samples ranged from 42...
2018: International Journal of Analytical Chemistry
Dongwook Lim, Sang-Deuk Kim, Hyungseok Kong, Daehyeon Nam, Sang Eun Shim, Sung-Hyeon Baeck
We propose a simple method to investigate both the qualitative and quantitative properties of titanium tetrachloride. The selection and concentration of the employed solvent were found to be very important in the analysis of highly reactive titanium tetrachloride (TiCl4 ). Herein, we employed various concentrations of an acid solution to serve as a stabilizing medium. Qualitative analysis was performed via Fourier transform-infrared spectroscopy (FT-IR) and scanning electron microscope-energy dispersive spectroscopy (SEM-EDS)...
2018: International Journal of Analytical Chemistry
Murad N Abualhasan, Abdel Naser Zaid, Nidal Jaradat, Ayman Mousa
[This corrects the article DOI: 10.1155/2017/1728414.].
2018: International Journal of Analytical Chemistry
Maja Hadzieva Gigovska, Ana Petkovska, Jelena Acevska, Natalija Nakov, Packa Antovska, Sonja Ugarkovic, Aneta Dimitrovska
This manuscript describes comprehensive approach for assessment of degradation behavior of simvastatin employing experimental design methodology as scientific multifactorial strategy. Experimental design methodology was used for sample preparation and UHPLC method development and optimization. Simvastatin was subjected to stress conditions of oxidative, acid, base, hydrolytic, thermal, and photolytic degradation. Using 2n full factorial design degradation conditions were optimized to obtain targeted level of degradation...
2018: International Journal of Analytical Chemistry
Tzu-Hsien Yu, Shuo-Ping Hsieh, Chien-Ming Su, Feng-Jung Huang, Chien-Che Hung, Lih-Ming Yiin
A quick and cost-effective method to analyze leafy vegetable nitrate on spectrometry was developed and compared with a standard method using high performance liquid chromatography (HPLC). This method was designed to use ion-exchange solid phase extraction (SPE) cartridges in reducing interference from organic matrices to meet the criterion of an existing method for analyzing nitrate in wastewater. Nine vegetables (bok coy, cabbage, celery, Chinese cabbage, Chinese kale, lettuce, mustard green, pak choi, and water spinach) were selected for the method testing with three replicates being conducted for each vegetable...
2018: International Journal of Analytical Chemistry
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