Reza Zare, Nader Tanideh, Behrooz Nikahval, Maryam Sadat Mirtalebi, Nasrollah Ahmadi, Shahrokh Zarea, Omid Koohi Hosseinabadi, Rohan Bhimani, Soheil Ashkani-Esfahani
Background: Osteoarthritis (OA) is a chronic disease and a significant cause of joint pain, tenderness, and limitation of motion. At present, no specific treatment is available, and mesenchymal stem cells (MSCs) have shown promising potentials in this regard. Herein, we aimed to evaluate the repairing potentials of stem cells derived from the synovium and fat pad in the treatment of OA. Methods: Twenty-eight male rats (220 ± 20 g, aged 10-12 weeks), were randomly divided into four groups ( n = 7): C1: nontreated group, C2: Hyalgan-treated group, E1: adipose tissue-derived stem cell-treated group, and E2: synovial membrane-based stem cell-treated group...
2020: International Journal of Rheumatology