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Journals International Journal of Rheum...

International Journal of Rheumatology

https://read.qxmd.com/read/33927768/update-in-the-management-of-anca-associated-vasculitis-recent-developments-and-future-perspectives
#21
REVIEW
Karla N Samman, Carolyn Ross, Christian Pagnoux, Jean-Paul Makhzoum
Significant progress has been made in the treatment of ANCA-associated vasculitides (AAV), notably in granulomatosis with polyangiitis and microscopic polyangiitis. Over the past few years, many innovative studies have changed the way we now induce and maintain remission in AAV; achieving remission while limiting treatment toxicity is the key. This article provides an in-depth, up-to-date summary of recent trials and suggests treatment algorithms for induction and maintenance of remission based on the latest guidelines...
2021: International Journal of Rheumatology
https://read.qxmd.com/read/33414828/clinical-outcomes-of-myocarditis-after-moderate-dose-steroid-therapy-in-systemic-sclerosis-a-pilot-study
#22
JOURNAL ARTICLE
Burabha Pussadhamma, Thapanee Tipparot, Naruemol Chaosuwannakit, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Ratanavadee Nanagara, Chingching Foocharoen
BACKGROUND: Myocarditis is reported in systemic sclerosis (SSc); however, treatment options and outcomes are limited. Our objective was to define cardiac outcomes after moderate-dose steroid therapy in SSc patients with myocarditis. METHOD: An open-label study was conducted among SSc patients with myocarditis-as defined by cardiovascular magnetic resonance (CMR), disease onset <5 years, and a NYHA functional class ≥II. All enrolled patients received prednisolone (30 mg/d) which would be tapered off by week 24, and CMR was followed up at the end of treatment...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/33101416/intracytoplasmic-expression-of-il-6-and-il-17a-in-circulating-cd4-t-cells-are-strongly-associated-with-and-predict-disease-activity-in-rheumatoid-arthritis-a-case-control-study-in-ghana
#23
JOURNAL ARTICLE
Samuel Asamoah Sakyi, Tonnies Abeku Buckman, Daniel Antwi-Berko, Kwame Yeboah-Mensah, Dzifa Dey, Eddie-Williams Owiredu, Benjamin Amoani, Richard Mantey
Background: T cell cytokines play important roles in the development and progression of rheumatoid arthritis (RA). Loss of Th1/Th2 and Th17/Treg balance has been reported in several inflammatory autoimmune diseases. However, their role in RA within hitherto rare Ghanaian context has not been explored. Here, we evaluated the intracytoplasmic CD4+ T cell cytokine patterns in rheumatoid arthritis patients in Ghana and determined their relationship with disease activity. Methods: This case-control study included 48 newly diagnosed RA patients and 30 apparent healthy controls from two major hospitals in Ghana...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32952562/direct-healthcare-costs-associated-with-oligoarticular-juvenile-idiopathic-arthritis-at-a-single-center
#24
JOURNAL ARTICLE
Amit Thakral, Daniel Pinto, Michael Miller, Megan L Curran, Marisa Klein-Gitelman, Dustin D French
Oligoarticular juvenile idiopathic arthritis (JIA) is a common disease in pediatric rheumatology. The management of oligoarticular JIA can result in a considerable economic burden. This study is a four-year, retrospective cost identification analysis performed to determine the annual direct cost of care for patients with oligoarticular JIA and possible predictive clinical factors. Direct healthcare costs were defined as those associated with office visits, laboratory studies, hospital admissions, joint injections, medications, infusions, radiology tests, and emergency room visits...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32908536/evaluation-effects-of-laser-therapy-and-extracorporeal-shock-wave-therapy-with-clinical-parameters-and-magnetic-resonance-imaging-for-treatment-of-plantar-fasciitis-in-patients-with-spondyloarthritis-a-randomized-controlled-trial
#25
JOURNAL ARTICLE
Kezban Armagan Alpturker, Ayse Beyhan Lale Cerrahoglu, Ihsan Sebnem Orguc
Objective: Low-level laser therapy (LLLT) and extracorporeal shock wave therapy (ESWT) is applied in the conservative treatment of inflammatory plantar fasciitis, which is also a characteristic feature of spondyloarthritis (SpA) (Gill, 1997 and Roxas, 2005). We determined and compared the effectiveness of LLLT and ESWT using magnetic resonance imaging (MRI). Methods: This study is a prospective, randomized, comparative, single-blind clinical study. Voluntarily followed 40 patients with the diagnosis of SpA and having pain at the heels at least for 6 months...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32908535/clinical-presentations-of-lumbar-disc-degeneration-and-lumbosacral-nerve-lesions
#26
REVIEW
Worku Abie Liyew
Lumbar disc degeneration is defined as the wear and tear of lumbar intervertebral disc, and it is mainly occurring at L3-L4 and L4-S1 vertebrae. Lumbar disc degeneration may lead to disc bulging, osteophytes, loss of disc space, and compression and irritation of the adjacent nerve root. Clinical presentations associated with lumbar disc degeneration and lumbosacral nerve lesion are discogenic pain, radical pain, muscular weakness, and cutaneous. Discogenic pain is usually felt in the lumbar region, or sometimes, it may feel in the buttocks, down to the upper thighs, and it is typically presented with sudden forced flexion and/or rotational moment...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32831850/serum-peptidomic-profile-as-a-novel-biomarker-for-rheumatoid-arthritis
#27
JOURNAL ARTICLE
Abeer A Abdelati, Rehab A Elnemr, Noha S Kandil, Fatma I Dwedar, Rasha A Ghazala
Over the last decades, there has been an increasing need to discover new diagnostic RA biomarkers, other than the current serologic biomarkers, which can assist early diagnosis and response to treatment. The purpose of this study was to analyze the serum peptidomic profile in patients with rheumatoid arthritis (RA) by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). The study included 35 patients with rheumatoid arthritis (RA), 35 patients with primary osteoarthritis (OA) as the disease control (DC), and 35 healthy controls (HC)...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32831849/vaccinations-do-not-increase-arthritis-flares-in-juvenile-idiopathic-arthritis-a-study-of-the-relationship-between-routine-childhood-vaccinations-on-the-australian-immunisation-schedule-and-arthritis-activity-in-children-with-juvenile-idiopathic-arthritis
#28
JOURNAL ARTICLE
Naba M Alfayadh, Peter J Gowdie, Jonathan D Akikusa, Mee Lee Easton, Jim P Buttery
Background: Juvenile idiopathic arthritis (JIA) is a collective term for a group of inflammatory conditions of uncertain origin, which causes chronic arthritis in one or more joints. The clinical course of JIA is characterised by episodes of increased activity, termed flares. Vaccinations have previously been proposed as a "trigger" for some flares, although evidence supporting this is scant. Objective: To explore whether routine childhood vaccinations are associated with an increased risk of flares of arthritis activity in children with JIA...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32765610/are-stem-cells-derived-from-synovium-and-fat-pad-able-to-treat-induced-knee-osteoarthritis-in-rats
#29
JOURNAL ARTICLE
Reza Zare, Nader Tanideh, Behrooz Nikahval, Maryam Sadat Mirtalebi, Nasrollah Ahmadi, Shahrokh Zarea, Omid Koohi Hosseinabadi, Rohan Bhimani, Soheil Ashkani-Esfahani
Background: Osteoarthritis (OA) is a chronic disease and a significant cause of joint pain, tenderness, and limitation of motion. At present, no specific treatment is available, and mesenchymal stem cells (MSCs) have shown promising potentials in this regard. Herein, we aimed to evaluate the repairing potentials of stem cells derived from the synovium and fat pad in the treatment of OA. Methods: Twenty-eight male rats (220 ± 20 g, aged 10-12 weeks), were randomly divided into four groups ( n = 7): C1: nontreated group, C2: Hyalgan-treated group, E1: adipose tissue-derived stem cell-treated group, and E2: synovial membrane-based stem cell-treated group...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32695177/correlation-between-c-reactive-protein-with-malondialdehyde-in-systemic-lupus-erythematosus-patients
#30
JOURNAL ARTICLE
Nur Atik, S Putri Pratiwi, Laniyati Hamijoyo
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by an inflammatory process. One of the inflammation markers that can be measured is C-reactive protein (CRP). Another indicator of inflammation is malondialdehyde (MDA), though it is still uncommon to be analyzed in SLE patients. The study looked for the MDA value and found a correlation with CRP. A cross-sectional study design with a correlative analytical was performed. CRP level data was taken from Hasan Sadikin lupus registry data, and MDA levels were analyzed from a bioarchive patient's serum...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32565819/oral-complementary-medicine-use-among-people-with-inflammatory-arthritis-an-australian-rheumatology-association-database-analysis
#31
JOURNAL ARTICLE
Ashley Fletcher, Marissa Lassere, Lyn March, Catherine Hill, Graeme Carroll, Claire Barrett, Rachelle Buchbinder
Objectives: To describe oral complementary medicine (CM) use in people with inflammatory arthritis, associations with use, and changes in use over time. Methods: Demographic, clinical, and patient-reported outcome data from 5,630 participants with rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA) were extracted from the Australian Rheumatology Association Database (ARAD), a national observational database...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32411251/clinical-and-immunological-profile-of-mixed-connective-tissue-disease-and-a-comparison-of-four-diagnostic-criteria
#32
JOURNAL ARTICLE
Kevin John John, Mohammad Sadiq, Tina George, Karthik Gunasekaran, Nirmal Francis, Ebenezer Rajadurai, Thambu David Sudarsanam
Mixed connective tissue disease (MCTD) was initially described as a chronic immune-mediated disease with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis. We conducted a cross-sectional study to describe the clinical and immunological profile of patients with MCTD and to compare the four diagnostic criteria, namely, Sharp, Kasukawa, Alarcón-Segovia, and Khan criteria. A total of 291 patients who were admitted from June 2007 to June 2017 and fulfilled the inclusion criteria were included in the study...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32411250/efficacy-of-vitamin-e-in-methotrexate-induced-hepatotoxicity-in-rheumatoid-arthritis-an-open-label-case-control-study
#33
JOURNAL ARTICLE
Binit Vaidya, Manisha Bhochhibhoya, Shweta Nakarmi
Objective: To examine the efficacy of vitamin E in methotrexate- (MTX-) induced transaminitis in patients with rheumatoid arthritis (RA). Methods: A case-control study was conducted at a tertiary rheumatology center for 12 months. Patients with RA on MTX and deranged aminotransferases were included. Patients with previous liver diseases, baseline transaminitis before methotrexate initiation, alcohol intake, muscle diseases, under hepatotoxic drugs, and aminotransferases > 3 times the upper normal limit were excluded...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32308689/changes-in-urinary-microalbumin-levels-after-correction-of-hyperuricemia-in-patients-with-gout-an-observational-cohort-study
#34
JOURNAL ARTICLE
Binit Vaidya, Kalpana Pudasaini, Shweta Nakarmi
Background: Gout is commonly associated with metabolic syndrome. Strong association between the serum uric acid level and microalbuminuria has also been observed in various studies. Aim: To observe the change in urinary microalbumin after urate-lowering treatment in patients with gout and microalbuminuria. Methodology . A prospective, observational study was conducted at a tertiary-level rheumatic center (NCRD) in Kathmandu, Nepal. Adults diagnosed with gout using the 2015 ACR/EULAR criteria and microalbuminuria were enrolled in the study after obtaining informed consent...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32190056/role-of-secreted-frizzled-related-protein-1-and-tumor-necrosis-factor-%C3%AE-tnf-%C3%AE-in-bone-loss-of-patients-with-rheumatoid-arthritis
#35
JOURNAL ARTICLE
Andi Raga Ginting, Rudy Hidayat, Sumariyono Sumariyono, Sukamto Koesnoe
Bone loss is one of the emerging extra-articular manifestations of rheumatoid arthritis. TNF- α is the main inflammatory cytokine that can directly increase bone resorption. However, its role in bone formation is still unknown, especially related to secreted frizzled-related protein 1 (SFRP-1), an osteoblast inhibitor. This study examines the correlation between TNF- α and SFRP-1, with a bone turn over marker (CTX and P1NP). This is a cross-sectional study with 38 subjects of premenopausal female patients with RA...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32180808/the-micro-immunotherapy-medicine-2larth%C3%A2-reduces-inflammation-and-symptoms-of-rheumatoid-arthritis-in-vivo
#36
JOURNAL ARTICLE
Ilaria Floris, Víctor García-González, Belen Palomares, Kurt Appel, Beatrice Lejeune
Background: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, which can cause cartilage and bone damages as well as pain and disability. In order to prevent disease progression, reduce pain, and major symptoms of RA, one good strategy consists in targeting proinflammatory cytokines that have the key role in the vicious circle of synovial inflammation and pain. The micro-immunotherapy medicine (MIM) 2LARTH® targets cytokines involved in inflammation. Aim: The aim of the study is to evaluate the effect of the MIM compared to vehicle in an in vivo model of RA, induced in mice after immunization with articular bovine type II collagen...
2020: International Journal of Rheumatology
https://read.qxmd.com/read/32148510/a-review-of-primary-vasculitis-mimickers-based-on-the-chapel-hill-consensus-classification
#37
REVIEW
Farah Zarka, Charles Veillette, Jean-Paul Makhzoum
Primary systemic vasculitides are rare diseases that may manifest similarly to more commonly encountered conditions. Depending on the size of the vessel affected (large vessel, medium vessel, or small vessel), different vasculitis mimics must be considered. Establishing the right diagnosis of a vasculitis mimic will prevent unnecessary immunosuppressive therapy.
2020: International Journal of Rheumatology
https://read.qxmd.com/read/31662761/demographic-and-clinical-patterns-of-rheumatoid-arthritis-in-an-emirati-cohort-from-united-arab-emirates
#38
JOURNAL ARTICLE
Rajaie Namas, Abhay Joshi, Zarmeena Ali, Jamal Al Saleh, Mohammed Abuzakouk
This retrospective cohort study aimed to assess the demographic and clinical characteristics of rheumatoid arthritis (RA) in Emirati patients attending Cleveland Clinic Abu Dhabi, a large tertiary center in the Middle East. In this study, 414 Emirati patients with RA were evaluated over a 3-year period from April 2015 to April 2018. All patients fulfilled the 2010 RA ACR/EULAR criteria and were assessed for demographic and clinical characteristics. The estimated RA prevalence rate in our population cohort was 2...
2019: International Journal of Rheumatology
https://read.qxmd.com/read/31275398/erratum-to-are-all-oral-cox-2-selective-inhibitors-the-same-a-consideration-of-celecoxib-etoricoxib-and-diclofenac
#39
Chris Walker
[This corrects the article DOI: 10.1155/2018/1302835.].
2019: International Journal of Rheumatology
https://read.qxmd.com/read/31191660/the-contribution-of-drugs-and-helicobacter-pylori-to-gastric-mucosa-changes-in-patients-with-systemic-lupus-erythematosus-and-antiphospholipid-syndrome
#40
JOURNAL ARTICLE
Tatiana M Reshetnyak, Irina A Doroshkevich, Natalia V Seredavkina, Evgeny L Nasonov, Igor V Maev, Vasiliy I Reshetnyak
BACKGROUND: The nature and rate of gastric mucosal (GM) damage in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) remain to be among the unsolved problems. OBJECTIVE: To define the role of H. pylori and drugs in the development of GM damages in SLE and APS. METHODS: A study was conducted on 85 patients with SLE and APS. All the patients underwent esophagogastroduodenoscopy with targeted biopsy of the mucosa of the gastric body and antrum...
2019: International Journal of Rheumatology
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