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International Journal of Rheumatology

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https://www.readbyqxmd.com/read/28210273/isolated-ro52-antibodies-as-immunological-marker-of-a-mild-phenotype-of-undifferentiated-connective-tissue-diseases
#1
Ana Alonso-Larruga, Sagrario Bustabad, José Antonio Navarro-Gonzálvez, Beatriz Rodríguez-Lozano, Andrés Franco, Yvelise Barrios
The term undifferentiated connective tissue disease (UCTD) is used to describe undiagnosed patients that do not fulfill classification criteria for definite connective tissue disease (Systemic Lupus, Systemic Sclerosis, Sjögren Syndrome, and Dermatomyositis/Polymyositis). It is important to find serological markers as predictors of the evolution or severity of these diseases. The objective of this retrospective study was to investigate if there was a milder subgroup of UCTD with a special clinical profile consisting only in the presence of anti-Ro52 autoantibodies...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28167963/physicians-perspectives-on-the-diagnosis-and-treatment-of-chronic-nonbacterial-osteomyelitis
#2
Yongdong Zhao, Fatma Dedeoglu, Polly J Ferguson, Sivia K Lapidus, Ronald M Laxer, Miranda C Bradford, Suzanne C Li
Background/Purpose. Understanding the practices of pediatric rheumatologists in diagnosing and treating chronic nonbacterial osteomyelitis (CNO) can provide important information to guide the development of consensus treatment plans. The objectives of this study were to determine physicians' approaches to (1) diagnosing and monitoring CNO, (2) ordering a bone biopsy, and (3) making treatment decisions. Methods. A survey was distributed among members of the Childhood Arthritis and Rheumatology Research Alliance using a web-based questionnaire...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28127309/validation-of-administrative-osteoarthritis-diagnosis-using-a-clinical-and-radiological-population-based-cohort
#3
M Mushfiqur Rahman, Jacek A Kopec, Charlie H Goldsmith, Aslam H Anis, Jolanda Cibere
Objectives. The validity of administrative osteoarthritis (OA) diagnosis in British Columbia, Canada, was examined against X-rays, magnetic resonance imaging (MRI), self-report, and the American College of Rheumatology criteria. Methods. During 2002-2005, 171 randomly selected subjects with knee pain aged 40-79 years underwent clinical assessment for OA in the knee, hip, and hands. Their administrative health records were linked during 1991-2004, in which OA was defined in two ways: (AOA1) at least one physician's diagnosis or hospital admission and (AOA2) at least two physician's diagnoses in two years or one hospital admission...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28115937/corrigendum-to-an-insight-into-methods-and-practices-in-hip-arthroplasty-in-patients-with-rheumatoid-arthritis
#4
Mohammad Saeed Mosleh-Shirazi, Mazin Ibrahim, Philip Pastides, Wasim Khan, Habib Rahman, Leila Jahangiri
[This corrects the article DOI: 10.1155/2015/140143.].
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28070192/immune-mediators-in-osteoarthritis-infrapatellar-fat-pad-infiltrating-cd8-t-cells-are-increased-in-osteoarthritic-patients-with-higher-clinical-radiographic-grading
#5
Jirun Apinun, Panjana Sengprasert, Pongsak Yuktanandana, Srihatach Ngarmukos, Aree Tanavalee, Rangsima Reantragoon
Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues. Many evidences suggest the role of both innate and adaptive immunity that interplay, resulting either in initiation or in progression of osteoarthritis. Adaptive immune cells, in particular T cells, have been demonstrated to play a role in the development of OA in animal models. However, the underlying mechanism is yet unclear. Our aim was to correlate the frequency and phenotype of tissue-infiltrating T cells in the synovial tissue and infrapatellar fat pad with radiographic grading...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28070191/serum-amyloid-a-level-in-egyptian-children-with-familial-mediterranean-fever
#6
Hala M Lofty, Huda Marzouk, Yomna Farag, Mohammad Nabih, Iman A S Khalifa, Noha Mostafa, Ahmed Salah, Laila Rashed, Kamal El Garf
Background and Objectives. SAA is an acute-phase reactant detected during an FMF attack or other inflammatory conditions. High SAA levels may increase the risk of amyloidosis. The aim of the study is to measure the serum amyloid A (SAA) level in a group of Egyptian children with familial Mediterranean fever (FMF) and study its various correlates, if any. Methods. The study enrolled seventy-one children with FMF. Results. SAA level was high in 78.9% of the studied patients with a mean of 81.62 ± 31.6 mg/L, and CRP was positive in 31% of patients...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/28042296/deferoxamine-suppresses-collagen-cleavage-and-protease-cytokine-and-col10a1-expression-and-upregulates-ampk-and-krebs-cycle-genes-in-human-osteoarthritic-cartilage
#7
Elena V Tchetina, Galina A Markova, A Robin Poole, David J Zukor, John Antoniou, Sergey A Makarov, Aleksandr N Kuzin
This study reports the effects of the iron chelator deferoxamine (DFO) on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA) articular cartilage. Full-depth explants of human OA knee articular cartilage from arthroplasty were cultured with exogenous DFO (1-50 μM). Type II collagen cleavage and phospho-adenosine monophosphate-activated protein kinase (pAMPK) concentrations were measured using ELISAs. Gene expression studies employed real-time PCR and included AMPK analyses in PBMCs...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/27847517/association-between-air-pollution-and-the-development-of-rheumatic-disease-a-systematic-review
#8
REVIEW
Gavin Sun, Glen Hazlewood, Sasha Bernatsky, Gilaad G Kaplan, Bertus Eksteen, Cheryl Barnabe
Objective. Environmental risk factors, such as air pollution, have been studied in relation to the risk of development of rheumatic diseases. We performed a systematic literature review to summarize the existing knowledge. Methods. MEDLINE (1946 to September 2016) and EMBASE (1980 to 2016, week 37) databases were searched using MeSH terms and keywords to identify cohort, case-control, and case cross-over studies reporting risk estimates for the development of select rheumatic diseases in relation to exposure of measured air pollutants (n = 8)...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/27833642/impact-of-anti-inflammatory-drugs-on-pyogenic-vertebral-osteomyelitis-a-prospective-cohort-study
#9
Aurélien Dinh, Maxime Jean, Frédérique Bouchand, Benjamin Davido, Alexis Descatha, Clara Duran, Guillaume Gras, Christian Perronne, Denis Mulleman, Jérôme Salomon, Louis Bernard
Objective. Pyogenic vertebral osteomyelitis (PVO) are frequently misdiagnosed and patients often receive anti-inflammatory drugs for their back pain. We studied the impact of these medications. Methods. We performed a prospective study enrolling patients with PVO and categorized them depending on their drugs intake. Then, we compared diagnosis delay, clinical presentation at hospitalization, incidence of complications, and cure rate. Results. In total, 79 patients were included. Multivariate analysis found no correlation between anti-inflammatory drug intake and diagnosis delay, clinical presentation, complications, or outcome...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/27630714/risk-of-malignant-neoplasm-in-patients-with-incident-rheumatoid-arthritis-1980-2007-in-relation-to-a-comparator-cohort-a-population-based-study
#10
Shafay Raheel, Cynthia S Crowson, Kerry Wright, Eric L Matteson
Objective. To determine whether the incidence of malignancy is increased in patients with rheumatoid arthritis (RA) compared to a matched comparison cohort and to identify risk for any individual malignancy in RA. Methods. A cohort of 813 Olmsted County, Minnesota, residents who first fulfilled 1987 ACR criteria for RA in 1980-2007 was previously identified by medical record review. Medical records of 813 RA cases and a comparison cohort of age and sex matched Olmsted County residents without RA were evaluated retrospectively for cancer occurrence...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/27493667/severity-of-osteoarthritis-is-associated-with-increased-arterial-stiffness
#11
Kaspar Tootsi, Jaak Kals, Mihkel Zilmer, Kaido Paapstel, Aare Märtson
Objective. Osteoarthritis (OA) is associated with increased cardiovascular comorbidity and mortality. Evidence is lacking about whether arterial stiffness is involved in OA. The objective of our study was to find out associations between OA, arterial stiffness, and adipokines. Design. Seventy end-stage knee and hip OA patients (age 62 ± 7 years) and 70 asymptomatic controls (age 60 ± 7 years) were investigated using the applanation tonometry to determine their parameters of arterial stiffness. Serum adiponectin, leptin, and matrix metalloproteinase 3 (MMP-3) levels were determined using the ELISA method...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/27413376/erratum-to-the-characteristics-and-significance-of-locally-infiltrating-b-cells-in-lupus-nephritis-and-their-association-with-local-baff-expression
#12
Chuan-Yin Sun, Yan Shen, Xiao-Wei Chen, Yu-Cheng Yan, Feng-Xia Wu, Ming Dai, Ting Li, Cheng-De Yang
[This corrects the article DOI: 10.1155/2013/954292.].
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/27247574/cardiac-function-and-diastolic-dysfunction-in-behcet-s-disease-a-systematic-review-and-meta-analysis
#13
REVIEW
Fawad Aslam, Salman J Bandeali, Cynthia Crowson, Mahboob Alam
Background. Cardiovascular involvement in Behcet's disease (BD) is reported and has variable manifestations. It is not clear if diastolic dysfunction (DD) is increased in BD. Our objective was to evaluate the existing literature to determine if cardiac dysfunction, particularly DD, was more prevalent in these patients. Methods. A systematic review and meta-analysis of the available studies analyzing the echocardiographic findings in BD was conducted using a random-effects model. Mean differences were used to calculate the effect sizes of the echocardiographic parameters of interest...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/27247573/the-reliability-of-a-novel-automated-system-for-ana-immunofluorescence-analysis-in-daily-clinical-practice
#14
Mohammed Alsuwaidi, Margit Dollinger, Martin Fleck, Boris Ehrenstein
Automated interpretation (AI) systems for antinuclear antibody (ANA) analysis have been introduced based on assessment of indirect immunofluorescence (IIF) patterns. The diagnostic performance of a novel automated IIF reading system was compared with visual interpretation (VI) of IIF in daily clinical practice to evaluate the reduction of workload. ANA-IIF tests of consecutive serum samples from patients with suspected connective tissue disease were carried out using HEp-2 cells according to routine clinical care...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/27200094/saphire-stress-and-pulmonary-hypertension-in-rheumatoid-evaluation-a-prevalence-study
#15
G E M Reeves, N Collins, P Hayes, J Knapp, M Squance, H Tran, B Bastian
Pulmonary artery hypertension (PAH) is a disorder of elevated resistance in the pulmonary arterial vessels, reflected by elevation of measured pulmonary artery pressure (PAP), and presenting with breathlessness and, if untreated, progressing to right heart failure and death. The heightened prevalence of PAH in populations with underlying systemic autoimmune conditions, particularly scleroderma and its variants, is well recognised, consistent with the proposed autoimmune contribution to PAH pathogenesis, along with disordered thrombotic, inflammatory, and mitogenic factors...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/27127514/the-diagnostic-value-of-alpha-1-antitrypsin-phenotype-in-patients-with-granulomatosis-with-polyangiitis
#16
M Y Pervakova, V L Emanuel, O N Titova, S V Lapin, V I Mazurov, I B Belyaeva, A L Chudinov, T V Blinova, E A Surkova
The deficiency of alpha-1 protease inhibitor, or alpha-1-antitrypsin (A1AT), predisposes to chronic lung diseases and extrapulmonary pathology. Besides classical manifestations, such as pulmonary emphysema and liver disease, alpha-1-antitrypsin deficiency (A1ATD) is also known to be associated with granulomatosis with polyangiitis (GPA or Wegener's granulomatosis). The aim of our study was to evaluate the frequency of allelic isoforms of A1AT and their clinical significance among GPA patients. Detailed clinical information, including Birmingham Vasculitis Activity Score (BVAS), incidence of lung involvement, anti-proteinase 3 (PR3) antibodies concentrations, and other laboratory data were collected in 38 GPA patients...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/27069477/vaccination-of-adult-patients-with-systemic-lupus-erythematosus-in-portugal
#17
REVIEW
Maria Francisca Moraes-Fontes, Ana Margarida Antunes, Heidi Gruner, Nuno Riso
In the wake of the Portuguese vaccination program 50th anniversary it seems appropriate to review vaccination in patients with systemic lupus erythematosus. Controversial issues as regards the association between autoimmune diseases, infections, and vaccines are discussed as well as vaccine safety and efficacy issues as regards chronic immunosuppressant (IS) drug therapy. After a brief overview of national policies, specific recommendations are made as regards vaccination for adult patients with SLE with a particular focus on current IS therapy and unmet needs...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/26949397/joint-degradation-in-a-monkey-model-of-collagen-induced-arthritis-role-of-cathepsin-k-based-on-biochemical-markers-and-histological-evaluation
#18
Makoto Tanaka, Hiroyuki Yamada, Satoshi Nishikawa, Hiroshi Mori, Yasuo Ochi, Naoto Horai, Minqi Li, Norio Amizuka
The role of cathepsin K in joint degradation in a model of collagen-induced arthritis (CIA) in cynomolgus monkey was examined using biochemical markers and histology. Joint swelling, urinary C-telopeptide of type II collagen (CTX-II), deoxypyridinoline (DPD), and N- and C-telopeptides of type I collagen (NTX and CTX-I, resp.) were analyzed. Immunohistochemistry of type II collagen, cathepsin K, and CTX-II were performed using joints. Joint swelling reached peak on day 42 and continued at this level. The CTX-II level peaked on day 28 and declined thereafter, while CTX-I, NTX, and DPD reached plateau on day 43...
2016: International Journal of Rheumatology
https://www.readbyqxmd.com/read/26798344/behcet-s-disease-is-there-geographical-variation-a-review-far-from-the-silk-road
#19
REVIEW
Nieves Marie Leonardo, Julian McNeil
Behcet's Disease (BD) is a systemic vasculitis characterized by the triad of recurrent mouth and genital ulcers with eye involvement. To date there are no laboratory tests specific for the disease and diagnosis continues to remain on clinical grounds. Multiple criteria have been created as guides for diagnosis; however, given the wide spectrum of organ involvement, some cases remain undiagnosed. The diagnosis of Behcet's Disease may only be made over time as the clinical manifestations emerge sometimes separated by months and even years...
2015: International Journal of Rheumatology
https://www.readbyqxmd.com/read/26793241/clinical-assessment-and-management-of-spondyloarthritides-in-the-middle-east-a-multinational-investigation
#20
Mohammed Hammoudeh, Hanan Al Rayes, Adel Alawadhi, Kamel Gado, Khalid Shirazy, Atul Deodhar
Data on spondyloarthritis (SpA) from the Middle East are sparse and the management of these diseases in this area of the world faces a number of challenges, including the relevant resources to enable early diagnosis and referral and sufficient funds to aid the most appropriate treatment strategy. The objective was to report on the characteristics, disease burden, and treatment of SpA in the Middle East region and to highlight where management strategies could be improved, with the overall aim of achieving better patient outcomes...
2015: International Journal of Rheumatology
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