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Journal of Transplantation

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https://www.readbyqxmd.com/read/27822384/immunomodulatory-role-of-mesenchymal-stem-cell-therapy-in-vascularized-composite-allotransplantation
#1
REVIEW
Richard Heyes, Andrew Iarocci, Yourka Tchoukalova, David G Lott
This review aims to summarize contemporary evidence of the in vitro and in vivo immunomodulatory effects of mesenchymal stem cells (MSCs) in promoting vascularized composite allotransplant (VCA) tolerance. An extensive literature review was performed to identify pertinent articles of merit. Prospective preclinical trials in mammal subjects receiving VCA (or skin allograft) with administration of MSCs were reviewed. Prospective clinical trials with intravascular delivery of MSCs in human populations undergoing solid organ transplant were also identified and reviewed...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27807479/everolimus-and-malignancy-after-solid-organ-transplantation-a-clinical-update
#2
REVIEW
Hallvard Holdaas, Paolo De Simone, Andreas Zuckermann
Malignancy after solid organ transplantation remains a major cause of posttransplant mortality. The mammalian target of rapamycin (mTOR) inhibitor class of immunosuppressants exerts various antioncogenic effects, and the mTOR inhibitor everolimus is licensed for the treatment of several solid cancers. In kidney transplantation, evidence from registry studies indicates a lower rate of de novo malignancy under mTOR inhibition, with some potentially supportive data from randomized trials of everolimus. Case reports and small single-center series have suggested that switch to everolimus may be beneficial following diagnosis of posttransplant malignancy, particularly for Kaposi's sarcoma and nonmelanoma skin cancer, but prospective studies are lacking...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27777790/utilization-of-public-health-service-increased-risk-donors-yields-equivalent-outcomes-in-liver-transplantation
#3
V A Fleetwood, J Lusciks, J Poirier, M Hertl, E Y Chan
Background. The PHS increased risk donor (IRD) is underutilized in liver transplantation. We aimed to examine the posttransplant outcomes in recipients of increased-risk organs. Methods. We analyzed 228,040 transplants in the Organ Procurement and Transplantation Network database from 2004 to 2013. Endpoints were graft failure and death. Results were controlled for demographics and comorbidities. Statistical analysis utilized Fisher's test and logistic regression. Results. 58,816 patients were identified (5,534 IRD, 53,282 non-IRD)...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27747096/manipulation-of-ovarian-function-significantly-influenced-sarcopenia-in-postreproductive-age-mice
#4
Rhett L Peterson, Kate C Parkinson, Jeffrey B Mason
Previously, transplantation of ovaries from young cycling mice into old postreproductive-age mice increased life span. We anticipated that the same factors that increased life span could also influence health span. Female CBA/J mice received new (60 d) ovaries at 12 and 17 months of age and were evaluated at 16 and 25 months of age, respectively. There were no significant differences in body weight among any age or treatment group. The percentage of fat mass was significantly increased at 13 and 16 months of age but was reduced by ovarian transplantation in 16-month-old mice...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27688905/impact-of-recipient-and-donor-obesity-match-on-the-outcomes-of-liver-transplantation-all-matches-are-not-perfect
#5
Eliza W Beal, Dmitry Tumin, Lanla F Conteh, A James Hanje, Anthony J Michaels, Don Hayes, Sylvester M Black, Khalid Mumtaz
There is a paucity of literature examining recipient-donor obesity matching on liver transplantation outcomes. The United Network for Organ Sharing database was queried for first-time recipients of liver transplant whose age was ≥18 between January 2003 and September 2013. Outcomes including patient and graft survival at 30 days, 1 year, and 5 years and overall, liver retransplantation, and length of stay were compared between nonobese recipients receiving a graft from nonobese donors and obese recipient-obese donor, obese recipient-nonobese donor, and nonobese recipient-obese donor pairs...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27688904/c1q-assay-results-in-complement-dependent-cytotoxicity-crossmatch-negative-renal-transplant-candidates-with-donor-specific-antibodies-high-specificity-but-low-sensitivity-when-predicting-flow-crossmatch
#6
José M Arreola-Guerra, Natalia Castelán, Adrián de Santiago, Adriana Arvizu, Norma Gonzalez-Tableros, Mayra López, Isaac Salcedo, Mario Vilatobá, Julio Granados, Luis E Morales-Buenrostro, Josefina Alberú
The aim of the present study was to describe the association of positive flow cross match (FXM) and C1q-SAB. Methods. In this observational, cross-sectional, and comparative study, patients included had negative AHG-CDC-XM and donor specific antibodies (DSA) and were tested with FXM. All pretransplant sera were tested with C1q-SAB assay. Results. A total of 50 donor/recipient evaluations were conducted; half of them had at least one C1q+ Ab (n = 26, 52%). Ten patients (20.0%) had DSA C1q+ Ab. Twenty-five (50%) FXMs were positive...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27597891/for-and-against-organ-donation-and-transplantation-intricate-facilitators-and-barriers-in-organ-donation-perceived-by-german-nurses-and-doctors
#7
Niels Christian Hvidt, Beate Mayr, Piret Paal, Eckhard Frick, Anna Forsberg, Arndt Büssing
Background. Significant facilitators and barriers to organ donation and transplantation remain in the general public and even in health professionals. Negative attitudes of HPs have been identified as the most significant barrier to actual ODT. The purpose of this paper was hence to investigate to what extent HPs (physicians and nurses) experience such facilitators and barriers in ODT and to what extent they are intercorrelated. We thus combined single causes to circumscribed factors of respective barriers and facilitators and analyzed them for differences regarding profession, gender, spiritual/religious self-categorization, and self-estimated knowledge of ODT and their mutual interaction...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27579174/the-kidney-transplant-evaluation-process-in-the-elderly-reasons-for-being-turned-down-and-opportunities-to-improve-cost-effectiveness-in-a-single-center
#8
Beatrice P Concepcion, Rachel C Forbes, Aihua Bian, Heidi M Schaefer
Background. The kidney transplant evaluation process for older candidates is complex due to the presence of multiple comorbid conditions. Methods. We retrospectively reviewed patients ≥60 years referred to our center for kidney transplantation over a 3-year period. Variables were collected to identify reasons for patients being turned down and to determine the number of unnecessary tests performed. Statistical analysis was performed to estimate the association between clinical predictors and listing status...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27493793/the-utility-of-routine-ultrasound-imaging-after-elective-transplant-ureteric-stent-removal
#9
Bibek Das, Dorian Hobday, Jonathon Olsburgh, Chris Callaghan
Background. Ureteric stent insertion during kidney transplantation reduces the incidence of major urological complications (MUCs). We evaluated whether routine poststent removal graft ultrasonography (PSRGU) was useful in detecting MUCs before they became clinically or biochemically apparent. Methods. A retrospective analysis was undertaken of clinical outcomes following elective stent removals from adult single renal transplant recipients (sRTRs) at our centre between 1 January 2011 and 31 December 2013. Results...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27478631/clinical-course-and-outcomes-of-late-kidney-allograft-dysfunction
#10
Viktor Denisov, Vadym Zakharov, Anna Ksenofontova, Eugene Onishchenko, Tatyana Golubova, Sergey Kichatyi, Olga Zakharova
Background. This study is provided to increase the efficiency of the treatment of kidney transplant recipients by predicting the development of the late allotransplant dysfunction. Methods. 330 patients who have lived for more than one year with functioning kidney allograft were evaluated. To predict the subsequent duration of the well-functioning of allotransplant the prognostic significance of 15 baseline clinical and sociodemographic characteristics on the results of the survey one year after transplantation was investigated...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27478630/intermediate-term-outcomes-of-dual-adult-versus-single-kidney-transplantation-evolution-of-a-surgical-technique
#11
Ana K Islam, Richard J Knight, Wesley A Mayer, Adam B Hollander, Samir Patel, Larry D Teeter, Edward A Graviss, Ashish Saharia, Hemangshu Podder, Emad H Asham, A Osama Gaber
Background. Acceptance of dual kidney transplantation (DKT) has proven difficult, due to surgical complexity and concerns regarding long-term outcomes. We herein present a standard technique for ipsilateral DKT and compare outcomes to single-kidney transplant (SKT) recipients. Methods. A retrospective single-center comparison of DKT and SKT performed between February 2007 and July 2013. Results. Of 516 deceased donor kidney transplants, 29 were DKT and 487 were SKT. Mean follow-up was 43 ± 67 months. DKT recipients were older and more likely than SKT recipients to receive an extended criteria graft (p < 0...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27418975/effectively-screening-for-coronary-artery-disease-in-patients-undergoing-orthotopic-liver-transplant-evaluation
#12
Bryan C Lee, Feng Li, Adam J Hanje, Khalid Mumtaz, Konstantinos D Boudoulas, Scott M Lilly
Coronary artery disease (CAD) is prevalent in patients with end-stage liver disease and associated with poor outcomes when undergoing orthotopic liver transplantation (OLT); however, noninvasive screening for CAD in this population is less sensitive. In an attempt to identify redundancy, we reviewed our experience among patients undergoing CAD screening as part of their OLT evaluation between May 2009 and February 2014. Demographic, clinical, and procedural characteristics were analyzed. Of the total number of screened patients (n = 132), initial screening was more common via stress testing (n = 100; 75...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27413539/current-treatment-approaches-to-hcc-with-a-special-consideration-to-transplantation
#13
REVIEW
N Bhardwaj, M T P R Perera, M A Silva
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. The mainstay of treatment of HCC has been both resectional and transplantation surgery. It is well known that, in selected, optimized patients, hepatectomy for HCC may be an option, even in patients with underlying cirrhosis. Resectable patients with early HCC and underlying liver disease are however increasingly being considered for transplantation because of potential for better disease-free survival and resolution of underlying liver disease, although this approach is limited by the availability of donor livers, especially in resectable patients...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27403337/incidence-characteristics-and-prognosis-of-incidentally-discovered-hepatocellular-carcinoma-after-liver-transplantation
#14
Walid El Moghazy, Samy Kashkoush, Glenda Meeberg, Norman Kneteman
Background. We aimed to assess incidentally discovered hepatocellular carcinoma (iHCC) over time and to compare outcome to preoperatively diagnosed hepatocellular carcinoma (pdHCC) and nontumor liver transplants. Methods. We studied adults transplanted with a follow-up of at least one year. Patients were divided into 3 groups according to diagnosis of hepatocellular carcinoma. Results. Between 1990 and 2010, 887 adults were transplanted. Among them, 121 patients (13.6%) had pdHCC and 32 patients (3.6%) had iHCC; frequency of iHCC decreased markedly over years, in parallel with significant increase in pdHCC...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/27057348/liver-transplantation-for-hepatocellular-carcinoma-a-single-center-resume-overlooking-four-decades-of-experience
#15
Nikos Emmanouilidis, Rickmer Peters, Bastian P Ringe, Zeynep Güner, Wolf Ramackers, Hüseyin Bektas, Frank Lehner, Michael Manns, Jürgen Klempnauer, Harald Schrem
Background. This is a single center oncological resume overlooking four decades of experience with liver transplantation (LT) for hepatocellular carcinoma (HCC). Methods. All 319 LT for HCC that were performed between 1975 and 2011 were included. Predictors for HCC recurrence (HCCR) and survival were identified by Cox regression, Kaplan-Meier analysis, Log Rank, and χ (2)-tests where appropriate. Results. HCCR was the single strongest hazard for survival (exp⁡(B) = 10.156). Hazards for HCCR were tumor staging beyond the histologic MILAN (exp⁡(B) = 3...
2016: Journal of Transplantation
https://www.readbyqxmd.com/read/26798504/lung-transplantation-in-patients-with-high-lung-allocation-scores-in-the-us-evidence-for-the-need-to-evaluate-score-specific-outcomes
#16
Jeremiah A Hayanga, Alena Lira, Tedi Vlahu, Jingyan Yang, Jonathan K Aboagye, Heather K Hayanga, James D Luketich, Jonathan D'Cunha
Objective. The lung allocation score (LAS) resulted in a lung transplantation (LT) selection process guided by clinical acuity. We sought to evaluate the relationship between LAS and outcomes. Methods. We analyzed Scientific Registry of Transplant Recipient (SRTR) data pertaining to recipients between 2005 and 2012. We stratified them into quartiles based on LAS and compared survival and predictors of mortality. Results. We identified 10,304 consecutive patients, comprising 2,576 in each LAS quartile (quartile 1 (26...
2015: Journal of Transplantation
https://www.readbyqxmd.com/read/26788361/risk-factors-associated-with-increased-morbidity-in-living-liver-donation
#17
Helry L Candido, Eduardo A da Fonseca, Flávia H Feier, Renata Pugliese, Marcel A Benavides, Enis D Silva, Karina Gordon, Marcelo Gama de Abreu, Jaume Canet, Paulo Chapchap, Joao Seda Neto
Living donor liver donation (LDLD) is an alternative to cadaveric liver donation. We aimed at identifying risk factors and developing a score for prediction of postoperative complications (POCs) after LDLD in donors. This is a retrospective cohort study in 688 donors between June 1995 and February 2014 at Hospital Sírio-Libanês and A.C. Camargo Cancer Center, in São Paulo, Brazil. Primary outcome was POC graded ≥III according to the Clavien-Dindo classification. Left lateral segment (LLS), left lobe (LL), and right lobe resections (RL) were conducted in 492 (71...
2015: Journal of Transplantation
https://www.readbyqxmd.com/read/26697207/plasma-exchange-for-the-recurrence-of-primary-focal-segmental-glomerulosclerosis-in-adult-renal-transplant-recipients-a-meta-analysis
#18
REVIEW
Georgios Vlachopanos, Argyrios Georgalis, Harikleia Gakiopoulou
Background. Posttransplant recurrence of primary focal segmental glomerulosclerosis (rFSGS) in the form of massive proteinuria is not uncommon and has detrimental consequences on renal allograft survival. A putative circulating permeability factor has been implicated in the pathogenesis leading to widespread use of plasma exchange (PLEX). We reviewed published studies to assess the role of PLEX on treatment of rFSGS in adults. Methods. Eligible manuscripts compared PLEX or variants with conventional care for inducing proteinuria remission (PR) in rFSGS and were identified through MEDLINE and reference lists...
2015: Journal of Transplantation
https://www.readbyqxmd.com/read/26649189/psychosocial-status-of-liver-transplant-candidates-in-iran-and-its-correlation-with-health-related-quality-of-life-and-depression-and-anxiety
#19
Maryam Banihashemi, Mohsen Hafezi, Mohsen Nasiri-Toosi, Ali Jafarian, Mohammad Reza Abbasi, Mohammad Arbabi, Maryam Abdi, Mahzad Khavarian, Ali-Akbar Nejatisafa
Objectives. The study was aimed at providing a psychosocial profile for Iranian liver transplant candidates referred to an established liver transplantation program. Material and Methods. Patients assessed for liver transplant candidacy in Imam Khomeini Hospital (Tehran, Iran) between March 2013 and September 2014 were included. The following battery of tests were administered: Psychosocial Assessment of Candidates for Transplant (PACT), the Short-Form health survey (SF-36), and Hospital Anxiety and Depression Scale (HADS)...
2015: Journal of Transplantation
https://www.readbyqxmd.com/read/26539298/influence-of-deceased-donor-and-pretransplant-recipient-parameters-on-early-overall-kidney-graft-survival-in-germany
#20
Carl-Ludwig Fischer-Fröhlich, Marcus Kutschmann, Johanna Feindt, Irene Schmidtmann, Günter Kirste, Nils R Frühauf, Ulrike Wirges, Axel Rahmel, Christina Schleicher
Background. Scarcity of grafts for kidney transplantation (KTX) caused an increased consideration of deceased donors with substantial risk factors. There is no agreement on which ones are detrimental for overall graft-survival. Therefore, we investigated in a nationwide multicentre study the impact of donor and recipient related risks known before KTX on graft-survival based on the original data used for allocation and graft acceptance. Methods. A nationwide deidentified multicenter study-database was created of data concerning kidneys donated and transplanted in Germany between 2006 and 2008 as provided by the national organ procurement organization (Deutsche Stiftung Organtransplantation) and BQS Institute...
2015: Journal of Transplantation
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