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International Journal of Biomaterials

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https://www.readbyqxmd.com/read/29765405/recent-progress-of-fabrication-of-cell-scaffold-by-electrospinning-technique-for-articular-cartilage-tissue-engineering
#1
REVIEW
Yingge Zhou, Joanna Chyu, Mimi Zumwalt
As a versatile nanofiber manufacturing technique, electrospinning has been widely employed for the fabrication of tissue engineering scaffolds. Since the structure of natural extracellular matrices varies substantially in different tissues, there has been growing awareness of the fact that the hierarchical 3D structure of scaffolds may affect intercellular interactions, material transportation, fluid flow, environmental stimulation, and so forth. Physical blending of the synthetic and natural polymers to form composite materials better mimics the composition and mechanical properties of natural tissues...
2018: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29686706/efficient-self-assembly-of-mpeg-end-capped-porous-silica-as-a-redox-sensitive-nanocarrier-for-controlled-doxorubicin-delivery
#2
Anh Khoa Nguyen, Thi Hiep Nguyen, Bui Quoc Bao, Long Giang Bach, Dai Hai Nguyen
Porous nanosilica (PNS) has been regarded as a promising candidate for controlled delivery of anticancer drugs. Unmodified PNS-based nanocarriers, however, showed a burst release of encapsulated drugs, which may limit their clinical uses. In this report, PNS was surface conjugated with adamantylamine (ADA) via disulfide bridges (-SS-), PNS-SS-ADA, which was further modified with cyclodextrin-poly(ethylene glycol) methyl ether conjugate (CD-mPEG) to form a core@shell structure PNS-SS-ADA@CD-mPEG for redox triggered delivery of doxorubicin (DOX), DOX/PNS-SS-ADA@CD-mPEG...
2018: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29552037/injectable-hydrogel-versus-plastically-compressed-collagen-scaffold-for-central-nervous-system-applications
#3
Magdalini Tsintou, Kyriakos Dalamagkas, Alexander Seifalian
Central Nervous System (CNS) repair has been a challenge, due to limited CNS tissue regenerative capacity. The emerging tools that neural engineering has to offer have opened new pathways towards the discovery of novel therapeutic approaches for CNS disorders. Collagen has been a preferable material for neural tissue engineering due to its similarity to the extracellular matrix, its biocompatibility, and antigenicity. The aim was to compare properties of a plastically compressed collagen hydrogel with the ones of a promising collagen-genipin injectable hydrogel and a collagen-only hydrogel for clinical CNS therapy applications...
2018: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29545825/strain-and-vibration-in-mesenchymal-stem-cells
#4
REVIEW
Brooke McClarren, Ronke Olabisi
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into any mesenchymal tissue, including bone, cartilage, muscle, and fat. MSC differentiation can be influenced by a variety of stimuli, including environmental and mechanical stimulation, scaffold physical properties, or applied loads. Numerous studies have evaluated the effects of vibration or cyclic tensile strain on MSCs towards developing a mechanically based method of differentiation, but there is no consensus between studies and each investigation uses different culture conditions, which also influence MSC fate...
2018: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29511380/modeling-and-synthesis-of-ag-and-ag-ni-allied-bimetallic-nanoparticles-by-green-method-optical-and-biological-properties
#5
Anuoluwa Abimbola Akinsiku, Enock Olugbenga Dare, Kolawole Oluseyi Ajanaku, Olayinka Oyewale Ajani, Joseph Adebisi O Olugbuyiro, Tolutope Oluwasegun Siyanbola, Oluwaseun Ejilude, Moses Eterigho Emetere
In the quest for environmental remediation which involves eco-friendly synthetic routes, we herein report synthesis and modeling of silver nanoparticles (Ag NPs) and silver/nickel allied bimetallic nanoparticles (Ag/Ni NPs) using plant-extract reduction method. Secondary metabolites in the leaf extract of Canna indica acted as reducing agent. Electronic transitions resulted in emergence of surface plasmon resonance in the regions of 416 nm (Ag NPs) and 421 nm (Ag/Ni NPs) during optical measurements. Further characterizations were done using TEM and EDX...
2018: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29483927/scaffolds-for-pelvic-floor-prolapse-logical-pathways
#6
REVIEW
Julio Bissoli, Homero Bruschini
Pelvic organ prolapse (POP) has borrowed principles of treatment from hernia repair and in the last two decades we saw reinforcement materials to treat POP with good outcomes in terms of anatomy but with alarming complication rates. Polypropylene meshes to specifically treat POP have been withdrawn from market by manufactures and a blank space was left to be filled with new materials. Macroporous monofilament meshes are ideal candidates and electrospinning emerged as a reliable method capable of delivering production reproducibility and customization...
2018: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29599800/application-of-synthetic-polymeric-scaffolds-in-breast-cancer-3d-tissue-cultures-and-animal-tumor-models
#7
Girdhari Rijal, Chandra Bathula, Weimin Li
Preparation of three-dimensional (3D) porous scaffolds from synthetic polymers is a challenge to most laboratories conducting biomedical research. Here, we present a handy and cost-effective method to fabricate polymeric hydrogel and porous scaffolds using poly(lactic-co-glycolic) acid (PLGA) or polycaprolactone (PCL). Breast cancer cells grown on 3D polymeric scaffolds exhibited distinct survival, morphology, and proliferation compared to those on 2D polymeric surfaces. Mammary epithelial cells cultured on PLGA- or PCL-coated slides expressed extracellular matrix (ECM) proteins and their receptors...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29434640/natural-composite-reinforced-by-lontar-borassus-flabellifer-fiber-an-experimental-study-on-open-hole-tensile-strength
#8
Jefri Bale, Kristomus Boimau, Marselinus Nenobesi
A research has been conducted in the present study to investigate the effect of hole configuration on tensile strength of lontar fiber-reinforced composites. The lontar fiber-reinforced composites used in this study were produced by hand lay-up process. The lontar fiber-reinforced composites consist of short random fiber of 5 cm that contains 32% of nominal fiber volume as the reinforcement and unsaturated polyester as the matrix. The results show that the differences of hole configuration have an effect on tensile strength of lontar fiber-reinforced composites...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29250114/tissue-engineered-vascular-graft-of-small-diameter-based-on-electrospun-polylactide-microfibers
#9
P V Popryadukhin, G I Popov, G Yu Yukina, I P Dobrovolskaya, E M Ivan'kova, V N Vavilov, V E Yudin
Tubular vascular grafts 1.1 mm in diameter based on poly(L-lactide) microfibers were obtained by electrospinning. X-ray diffraction and scanning electron microscopy data demonstrated that the samples treated at T = 70°C for 1 h in the fixed state on a cylindrical mandrel possessed dense fibrous structure; their degree of crystallinity was approximately 44%. Strength and deformation stability of these samples were higher than those of the native blood vessels; thus, it was possible to use them in tissue engineering as bioresorbable vascular grafts...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29250113/encapsulation-of-nicardipine-hydrochloride-and-release-from-biodegradable-poly-d-l-lactic-co-glycolic-acid-microparticles-by-double-emulsion-process-effect-of-emulsion-stability-and-different-parameters-on-drug-entrapment
#10
Nopparuj Soomherun, Narumol Kreua-Ongarjnukool, Sorayouth Chumnanvej, Saowapa Thumsing
Poly(D,L-lactic-co-glycolic acid) (PLGA) is an important material used in drug delivery when controlled release is required. The purpose of this research is to design and characterize PLGA microparticles (PLGA MPs) implants for the controlled release of nicardipine hydrochloride (NCH) in vitro . This study used the water-in-oil-in-water (w1 /o/w2 ) double emulsion and solvent diffusion/evaporation approach to prepare PLGA MPs. Optimal processing conditions were found, such as polymer content, surfactant type, stabilizer concentration, inner and outer aqueous phase volumes, and stirring speed...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29093738/comparative-effectiveness-of-bone-grafting-using-xenograft-freeze-dried-cortical-bovine-allograft-freeze-dried-cortical-new-zealand-white-rabbit-xenograft-hydroxyapatite-bovine-and-xenograft-demineralized-bone-matrix-bovine-in-bone-defect-of-femoral-diaphysis
#11
Ferdiansyah Mahyudin, Dwikora Novembri Utomo, Heri Suroto, Tri Wahyu Martanto, Mouli Edward, Imelda Lumban Gaol
Autogenous bone graft is gold standard in treating bone defects, but it might have difficulty in corporation and rejection reaction. This study is to compare the effectiveness among freeze-dried xenograft, freeze-dried allograft, hydroxyapatite xenograft, and demineralized bone matrix xenograft as bone graft to fill bone defect in femoral diaphysis of white rabbit. Thirty male New Zealand white rabbits were distributed into five groups. Bone defect was filled correspondingly with xenograft freeze-dried cortical bovine, allograft freeze-dried cortical New Zealand white rabbit, xenograft hydroxyapatite bovine, and xenograft demineralized bone matrix bovine...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/29056968/effect-of-injection-molding-melt-temperatures-on-plga-craniofacial-plate-properties-during-in-vitro-degradation
#12
Liliane Pimenta de Melo, Gean Vitor Salmoria, Eduardo Alberto Fancello, Carlos Rodrigo de Mello Roesler
The purpose of this article is to present mechanical and physicochemical properties during in vitro degradation of PLGA material as craniofacial plates based on different values of injection molded temperatures. Injection molded plates were submitted to in vitro degradation in a thermostat bath at 37 ± 1°C by 16 weeks. The material was removed after 15, 30, 60, and 120 days; then bending stiffness, crystallinity, molecular weights, and viscoelasticity were studied. A significant decrease of molecular weight and mechanical properties over time and a difference in FT-IR after 60 days showed faster degradation of the material in the geometry studied...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28947903/influence-of-vanadium-4-and-5-ions-on-the-differentiation-and-activation-of-human-osteoclasts
#13
Matthias A König, Oliver P Gautschi, Hans-Peter Simmen, Luis Filgueira, Dieter Cadosch
BACKGROUND: In the pathophysiology of implant failure, metal ions and inflammation-driven osteoclasts (OC) play a crucial role. The aim of this study was to investigate whether vanadium (V) ions induce differentiation of monocytic OC precursors into osteoresorptive multinucleated cells. In addition, the influence of V ions on the activation and function of in vitro generated OC was observed. METHODS: Human monocytes and osteoclasts were isolated from peripheral blood monocytic cells (PBMCs)...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28912813/silicone-substrate-with-collagen-and-carbon-nanotubes-exposed-to-pulsed-current-for-msc-osteodifferentiation
#14
Daniyal Jamal, Roche C de Guzman
Autologous human adipose tissue-derived mesenchymal stem cells (MSCs) have the potential for clinical translation through their induction into osteoblasts for regeneration. Bone healing can be driven by biophysical stimulation using electricity for activating quiescent adult stem cells. It is hypothesized that application of electric current will enhance their osteogenic differentiation, and addition of conductive carbon nanotubes (CNTs) to the cell substrate will provide increased efficiency in current transmission...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28848605/influence-of-processing-conditions-on-the-mechanical-behavior-and-morphology-of-injection-molded-poly-lactic-co-glycolic-acid-85-15
#15
Liliane Pimenta de Melo, Gean Vitor Salmoria, Eduardo Alberto Fancello, Carlos Rodrigo de Mello Roesler
Two groups of PLGA specimens with different geometries (notched and unnotched) were injection molded under two melting temperatures and flow rates. The mechanical properties, morphology at the fracture surface, and residual stresses were evaluated for both processing conditions. The morphology of the fractured surfaces for both specimens showed brittle and smooth fracture features for the majority of the specimens. Fracture images of the notched specimens suggest that the surface failure mechanisms are different from the core failure...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28814954/intrinsic-osteoinductivity-of-porous-titanium-scaffold-for-bone-tissue-engineering
#16
Maryam Tamaddon, Sorousheh Samizadeh, Ling Wang, Gordon Blunn, Chaozong Liu
Large bone defects and nonunions are serious complications that are caused by extensive trauma or tumour. As traditional therapies fail to repair these critical-sized defects, tissue engineering scaffolds can be used to regenerate the damaged tissue. Highly porous titanium scaffolds, produced by selective laser sintering with mechanical properties in range of trabecular bone (compressive strength 35 MPa and modulus 73 MPa), can be used in these orthopaedic applications, if a stable mechanical fixation is provided...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28694826/magnesium-oxide-nanoparticles-reinforced-electrospun-alginate-based-nanofibrous-scaffolds-with-improved-physical-properties
#17
R T De Silva, M M M G P G Mantilaka, K L Goh, S P Ratnayake, G A J Amaratunga, K M Nalin de Silva
Mechanically robust alginate-based nanofibrous scaffolds were successfully fabricated by electrospinning method to mimic the natural extracellular matrix structure which benefits development and regeneration of tissues. Alginate-based nanofibres were electrospun from an alginate/poly(vinyl alcohol) (PVA) polyelectrolyte complex. SEM images revealed the spinnability of the complex composite nanofibrous scaffolds, showing randomly oriented, ultrafine, and virtually defects-free alginate-based/MgO nanofibrous scaffolds...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28611845/novel-nanotechnology-of-tio2-improves-physical-chemical-and-biological-properties-of-glass-ionomer-cement
#18
Daniela Dellosso Cibim, Miki Taketomi Saito, Priscila Alves Giovani, Ana Flávia Sanches Borges, Vanessa Gallego Arias Pecorari, Orisson Ponce Gomes, Paulo Noronha Lisboa-Filho, Francisco Humberto Nociti-Junior, Regina Maria Puppin-Rontani, Kamila Rosamilia Kantovitz
The aim of this study was to assess the performance of glass ionomer cement (GIC) added with TiO2 nanotubes. TiO2 nanotubes [3%, 5%, and 7% (w/w)] were incorporated into GIC's (Ketac Molar EasyMix™) powder component, whereas unblended powder was used as control. Physical-chemical-biological analysis included energy dispersive spectroscopy (EDS), surface roughness (SR), Knoop hardness (SH), fluoride-releasing analysis, cytotoxicity, cell morphology, and extracellular matrix (ECM) composition. Parametric or nonparametric ANOVA were used for statistical comparisons (α ≤ 0...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28592972/fabrication-of-polycaprolactone-polyurethane-loading-conjugated-linoleic-acid-and-its-antiplatelet-adhesion
#19
Ho Hieu Minh, Nguyen Thi Hiep, Nguyen Dai Hai, Vo Van Toi
Polycaprolactone/polyurethane (PCL/PU) fibrous scaffold was loaded with conjugated linoleic acid (CLA) by electrospinning method to improve the hemocompatibility of the polymeric surface. Fourier Transform Infrared Spectroscopy (FT-IR) analysis and Scanning Electron Microscopy (SEM) observation were employed to characterize the chemical structure and the changing morphology of electrospun PCL/PU and PCL/PU loaded with CLA (PCL/PU-CLA) scaffolds. Platelet adhesion and whole blood clot formation tests were used to evaluate the effect of CLA on antithrombotic property of PCL/PU-CLA scaffold...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28572823/stabilisation-of-collagen-sponges-by-glutaraldehyde-vapour-crosslinking
#20
Yong Y Peng, Veronica Glattauer, John A M Ramshaw
Glutaraldehyde is a well-recognised reagent for crosslinking and stabilising collagens and other protein-based materials, including gelatine. In some cases, however, the use of solutions can disrupt the structure of the material, for example, by causing rapid dispersion or distortions from surface interactions. An alternative approach that has been explored in a number of individual cases is the use of glutaraldehyde vapour. In this study, the effectiveness of a range of different glutaraldehyde concentrations in the reservoir providing vapour, from 5% to 25% (w/v), has been explored at incubation times from 5 h to 48 h at room temperature...
2017: International Journal of Biomaterials
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