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International Journal of Biomaterials

Jozef Mincik, Daniel Urban, Silvia Timkova, Renata Urban
The aim of this study is to compare the effect of various restorative materials on fracture resistance in maxillary premolars. Premolars (n = 64) with no restorations or cracks were selected. MOD cavities were prepared considering the buccolingual width to be equal to half of the intercuspal distance. The specimens were randomly divided into 8 groups, 8 specimens each: group A intact teeth, group B unfilled cavity, group C composite made by oblique layering technique, group D composite with 2 mm cusp coverage, group E bulk-filled posterior composite, group F glass-ionomer, group G amalgam, and group H composite with proximal boxes...
2016: International Journal of Biomaterials
Melisa A Quinteros, Ivana M Aiassa Martínez, Pablo R Dalmasso, Paulina L Páez
Currently, the biosynthesis of silver-based nanomaterials attracts enormous attention owing to the documented antimicrobial properties of these ones. This study reports the extracellular biosynthesis of silver nanoparticles (Ag-NPs) using a Pseudomonas aeruginosa strain from a reference culture collection. A greenish culture supernatant of P. aeruginosa incubated at 37°C with a silver nitrate solution for 24 h changed to a yellowish brown color, indicating the formation of Ag-NPs, which was confirmed by UV-vis spectroscopy, transmission electron microscopy, and X-ray diffraction...
2016: International Journal of Biomaterials
Manoti Sehgal, Akshay Bhargava, Sharad Gupta, Prateek Gupta
A study was undertaken to evaluate the effect of artificial aging through steam and thermal treatment as influencing the shear bond strength between three different commercially available zirconia core materials, namely, Upcera, Ziecon, and Cercon, layered with VITA VM9 veneering ceramic using Universal Testing Machine. The mode of failure between zirconia and ceramic was further analyzed as adhesive, cohesive, or mixed using stereomicroscope. X-ray diffraction and SEM (scanning electron microscope) analysis were done to estimate the phase transformation (m-phase fraction) and surface grain size of zirconia particles, respectively...
2016: International Journal of Biomaterials
Ana M Cortizo, Graciela Ruderman, Flavia N Mazzini, M Silvina Molinuevo, Ines G Mogilner
Bone and cartilage regeneration can be improved by designing a functionalized biomaterial that includes bioactive drugs in a biocompatible and biodegradable scaffold. Based on our previous studies, we designed a vanadium-loaded collagen scaffold for osteochondral tissue engineering. Collagen-vanadium loaded scaffolds were characterized by SEM, FTIR, and permeability studies. Rat bone marrow progenitor cells were plated on collagen or vanadium-loaded membranes to evaluate differences in cell attachment, growth and osteogenic or chondrocytic differentiation...
2016: International Journal of Biomaterials
Afaf Al-Haddad, Zeti A Che Ab Aziz
Bioceramic-based root canal sealers are considered to be an advantageous technology in endodontics. The aim of this review was to consider laboratory experiments and clinical studies of these sealers. An extensive search of the endodontic literature was made to identify publications related to bioceramic-based root canal sealers. The outcome of laboratory and clinical studies on the biological and physical properties of bioceramic-based sealers along with comparative studies with other sealers was assessed...
2016: International Journal of Biomaterials
Hooman Khorshidi, Saeed Raoofi, Afagh Moattari, Atoosa Bagheri, Mohammad Hassan Kalantari
Background and Aim. The geometry of implant-abutment interface (IAI) affects the risk of bacterial leakage and invasion into the internal parts of the implant. The aim of this study was to compare the bacterial leakage of an 11-degree Morse taper IAI with that of a butt joint connection. Materials and Methods. Two implants systems were tested (n = 10 per group): CSM (submerged) and TBR (connect). The deepest inner parts of the implants were inoculated with 2 μL of Streptococcus mutans suspension with a concentration of 108 CFU/mL...
2016: International Journal of Biomaterials
Romina Croci, Elisabetta Bottaro, Kitti Wing Ki Chan, Satoru Watanabe, Margherita Pezzullo, Eloise Mastrangelo, Claudio Nastruzzi
RNA virus infections can lead to the onset of severe diseases such as fever with haemorrhage, multiorgan failure, and mortality. The emergence and reemergence of RNA viruses continue to pose a significant public health threat worldwide with particular attention to the increasing incidence of flaviviruses, among others Dengue, West Nile Virus, and Yellow Fever viruses. Development of new and potent antivirals is thus urgently needed. Ivermectin, an already known antihelminthic drug, has shown potent effects in vitro on Flavivirus helicase, with EC50 values in the subnanomolar range for Yellow Fever and submicromolar EC50 for Dengue Fever, Japanese encephalitis, and tick-borne encephalitis viruses...
2016: International Journal of Biomaterials
Maidy Rehder Wimmers Ferreira, Roger Rodrigo Fernandes, Amanda Freire Assis, Janaína A Dernowsek, Geraldo A Passos, Fabio Variola, Karina Fittipaldi Bombonato-Prado
Titanium implants have been extensively used in orthopedic and dental applications. It is well known that micro- and nanoscale surface features of biomaterials affect cellular events that control implant-host tissue interactions. To improve our understanding of how multiscale surface features affect cell behavior, we used microarrays to evaluate the transcriptional profile of osteoblastic cells from human alveolar bone cultured on engineered titanium surfaces, exhibiting the following topographies: nanotexture (N), nano+submicrotexture (NS), and rough microtexture (MR), obtained by modulating experimental parameters (temperature and solution composition) of a simple yet efficient chemical treatment with a H2SO4/H2O2 solution...
2016: International Journal of Biomaterials
Loreto M Valenzuela, Doyle D Knight, Joachim Kohn
Prediction of the dynamic properties of water uptake across polymer libraries can accelerate polymer selection for a specific application. We first built semiempirical models using Artificial Neural Networks and all water uptake data, as individual input. These models give very good correlations (R (2) > 0.78 for test set) but very low accuracy on cross-validation sets (less than 19% of experimental points within experimental error). Instead, using consolidated parameters like equilibrium water uptake a good model is obtained (R (2) = 0...
2016: International Journal of Biomaterials
Alexandra Vinagre, João Ramos, Sofia Alves, Ana Messias, Nélia Alberto, Rogério Nogueira
Polymerization shrinkage is a major concern to the clinical success of direct composite resin restorations. The aim of this study was to compare the effect of polymerization shrinkage strain of two resin composites on cuspal movement based on the use of fiber Bragg grating (FBG) sensors. Twenty standardized Class II cavities prepared in upper third molars were allocated into two groups (n = 10). Restorations involved the bulk fill placement of conventional microhybrid resin composite (Esthet•X® HD, Dentsply DeTrey) (Group 1) or flowable "low-shrinkage" resin composite (SDR™, Dentsply DeTrey) (Group 2)...
2016: International Journal of Biomaterials
Davood Almasi, Nida Iqbal, Maliheh Sadeghi, Izman Sudin, Mohammed Rafiq Abdul Kadir, Tunku Kamarul
There is an increased interest in the use of polyether ether ketone (PEEK) for orthopedic and dental implant applications due to its elastic modulus close to that of bone, biocompatibility, and its radiolucent properties. However, PEEK is still categorized as bioinert due to its low integration with surrounding tissues. Many studies have reported on methods to increase the bioactivity of PEEK, but there is still one-preparation method for preparing bioactive PEEK implant where the produced implant with desirable mechanical and bioactivity properties is required...
2016: International Journal of Biomaterials
Peter Panfilov, Dmitry Zaytsev, Olga V Antonova, Victoria Alpatova, Larissa P Kiselnikova
Objective. The cause of considerable elasticity and plasticity of human dentin is discussed in the relationship with its microstructure. Methods. Structural state of teenage and mature human dentin is examined by using XRD and TEM techniques, and their deformation behavior under compression is studied as well. Result. XRD study has shown that crystallographic type of calcium hydroxyapatite in human dentin (calcium hydrogen phosphate hydroxide Ca9HPO4(PO4)5OH; Space Group P63/m (176); a = 9,441 A; c = 6,881 A; c/a = 0,729; Crystallite (Scherrer) 200 A) is the same for these age groups...
2016: International Journal of Biomaterials
Georgios S Theodorou, Eleana Kontonasaki, Anna Theocharidou, Athina Bakopoulou, Maria Bousnaki, Christina Hadjichristou, Eleni Papachristou, Lambrini Papadopoulou, Nikolaos A Kantiranis, Konstantinos Chrissafis, Konstantinos M Paraskevopoulos, Petros T Koidis
Glass-ceramic scaffolds containing Mg have shown recently the potential to enhance the proliferation, differentiation, and biomineralization of stem cells in vitro, property that makes them promising candidates for dental tissue regeneration. An additional property of a scaffold aimed at dental tissue regeneration is to protect the regeneration process against oral bacteria penetration. In this respect, novel bioactive scaffolds containing Mg(2+) and Cu(2+) or Zn(2+), ions known for their antimicrobial properties, were synthesized by the foam replica technique and tested regarding their bioactive response in SBF, mechanical properties, degradation, and porosity...
2016: International Journal of Biomaterials
J R Anusha, Albin T Fleming
We report the synthesis, characterization, and biological properties of chitosan nanoaggregates from gladius of squid, Uroteuthis duvauceli. β-Chitin extracted from gladius was deacetylated to chitosan and further reduced to nanosize using ionic gelation process. The morphology and occurrence of chitosan nanoaggregates (CSNA) were observed using transmission electron microscopy (TEM). The degree of deacetylation (DD%) calculated from Fourier transform infrared (FTIR) spectrum showed high value (~94 ± 1.25%) for chitosan...
2016: International Journal of Biomaterials
Morshed Khandaker, Albert Orock, Stefano Tarantini, Jeremiah White, Ozlem Yasar
Nutrient conduit networks can be introduced within the Polyethylene Glycol Diacrylate (PEGDA) tissue construct to enable cells to survive in the scaffold. Nutrient conduit networks can be created on PEGDA by macrochannel to nanochannel fabrication techniques. Such networks can influence the mechanical and cell activities of PEGDA scaffold. There is no study conducted to evaluate the effect of nutrient conduit networks on the maximum tensile stress and cell activities of the tissue scaffold. The study aimed to explore the influence of the network architecture on the maximum tensile stress of PEGDA scaffold and compared with the nonnetworked PEGDA scaffold...
2016: International Journal of Biomaterials
Kanchan Maji, Sudip Dasgupta, Krishna Pramanik, Akalabya Bissoyi
The aim of the present study was to prepare and characterize bioglass-natural biopolymer based composite scaffold and evaluate its bone regeneration ability. Bioactive glass nanoparticles (58S) in the size range of 20-30 nm were synthesized using sol-gel method. Porous scaffolds with varying bioglass composition from 10 to 30 wt% in chitosan, gelatin matrix were fabricated using the method of freeze drying of its slurry at 40 wt% solids loading. Samples were cross-linked with glutaraldehyde to obtain interconnected porous 3D microstructure with improved mechanical strength...
2016: International Journal of Biomaterials
Farnaz Hajifattahi, Elham Moravej-Salehi, Maryam Taheri, Arash Mahboubi, Mohammad Kamalinejad
Objectives. This study aimed to assess the effect of hydroalcoholic extract of Punica granatum Linn. (P. granatum) petal on Streptococcus sanguinis, Streptococcus mutans, Streptococcus salivarius, Streptococcus sobrinus, and Enterococcus faecalis. Materials and Methods. In this in vitro study, P. granatum extract was prepared using powdered petals and water-ethanol solvent. Antibacterial effect of the extract, chlorhexidine (CHX), and ampicillin was evaluated on brain heart infusion agar (BHIA) using the cup-plate method...
2016: International Journal of Biomaterials
Viswanathan Gayathri, Varma Harikrishnan, Parayanthala Valappil Mohanan
Adipose Derived Mesenchymal Stem Cells, multipotent stem cells isolated from adipose tissue, present close resemblance to the natural in vivo milieu and microenvironment of bone tissue and hence widely used for in bone tissue engineering applications. The present study evaluates the compatibility of tissue engineered hydroxyapatite burr hole button device (HAP-BHB) seeded with Rabbit Adipose Derived Mesenchymal Stem Cells (ADMSCs). Cytotoxicity, oxidative stress response, apoptotic behavior, attachment, and adherence of adipose MSC seeded on the device were evaluated by scanning electron and confocal microscopy...
2016: International Journal of Biomaterials
Horieh Moosavi, Hamideh Sadat Mohammadipour, Marjaneh Ghavamnasiri, Sanaz Alizadeh
The aim of this study was to evaluate the effect of bleaching and thermocycling on microshear bond strength of bonded resin composites to enamel. Enamel slices were prepared from ninety-six intact human premolars and resin composite cylinders were bonded by using Adper Single Bond 2 + Filtek Z350 or Filtek silorane adhesive and resin composite. Each essential group was randomly subdivided to two subgroups: control and bleaching. In bleaching group, 35% hydrogen peroxide was applied on samples. Thermocycling procedure was conducted between 5°C and 55°C, for 3...
2015: International Journal of Biomaterials
Akanksha Gupta, Suresh D Kedige, Kanu Jain
The periodontal therapy usually aims at elimination of disease causing bacteria and resolution of inflammation. It involves either resective or regenerative surgery to resolve the inflammation associated defects. Over the years, several methods have been used for achievement of periodontal regeneration. One of the oldest biomaterials used for scaffolds is the fetal membrane. The amniotic membranes of developing embryo, that is, amnion (innermost lining) and chorion (a layer next to it), have the properties with significant potential uses in dentistry...
2015: International Journal of Biomaterials
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