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Hormones & Cancer

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https://www.readbyqxmd.com/read/30014218/impact-of-gender-and-age-on-the-prognosis-of-differentiated-thyroid-carcinoma-a-retrospective-analysis-based-on-seer
#1
Dan Zhang, Jianing Tang, Deguang Kong, Qiuxia Cui, Kun Wang, Yan Gong, Gaosong Wu
The incidence of thyroid cancer in females is significantly higher than that in males; however, females are more likely to have more favorable outcomes. We aimed to determine the characteristics of differentiated thyroid carcinoma (DTC) subtypes in males and females, and to compare their clinical behavior and survival. A total of 68,337 cases were recruited from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program. The disease-specific survival (DSS) of follicular variant papillary thyroid carcinoma (FVPTC) and follicular thyroid carcinoma (FTC) were similar to that of classical variant papillary thyroid carcinoma (CPTC) in male patients (FVPTC vs...
July 16, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29987748/rage-and-its-ligands-molecular-interplay-between-glycation-inflammation-and-hallmarks-of-cancer-a-review
#2
REVIEW
Gowri Palanissami, Solomon F D Paul
Risk of cancer especially of colon, breast, and pancreas is high in diabetic and obese patients, with potential involvement of augmented expression of RAGE (receptor for advanced glycation end products) and its ligands, namely AGEs (advanced glycation end products), HMGB1 (high-mobility group box 1 protein), and S100 group of proteins. Studies have reported the involvement of RAGE activation by its ligands in growth and survival of cancers, including metastasis and poor prognosis. We propose that this receptor-ligand axis provides the molecular link between certain pre-existing states as hypoxia, hyperglycemia, glycation, inflammation, oxidative stress, and onset of cancers...
July 9, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29956066/increased-high-molecular-weight-fgf2-in-endocrine-resistant-breast-cancer
#3
Ana Sahores, Virginia Figueroa, María May, Marcos Liguori, Adrián Rubstein, Cynthia Fuentes, Britta M Jacobsen, Andrés Elía, Paola Rojas, Gonzalo R Sequeira, Michelle M Álvarez, Pedro González, Hugo Gass, Stephen Hewitt, Alfredo Molinolo, Claudia Lanari, Caroline A Lamb
Endocrine resistance may develop as a consequence of enhanced growth factor signaling. Fibroblast growth factor 2 (FGF2) consists of a low and several high molecular weight forms (HMW-FGF2). We previously demonstrated that antiprogestin-resistant mammary carcinomas display lower levels of progesterone receptor A isoforms (PRA) than B isoforms (PRB). Our aim was to evaluate the role of FGF2 isoforms in breast cancer progression. We evaluated FGF2 expression, cell proliferation, and pathway activation in models with different PRA/PRB ratios...
June 28, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29951943/rna-sequencing-of-carboplatin-and-paclitaxel-resistant-endometrial-cancer-cells-reveals-new-stratification-markers-and-molecular-targets-for-cancer-treatment
#4
Raffaele Hellweg, Ashley Mooneyham, Zenas Chang, Mihir Shetty, Edith Emmings, Yoshie Iizuka, Christopher Clark, Timothy Starr, Juan H Abrahante, Florian Schütz, Gottfried Konecny, Peter Argenta, Martina Bazzaro
Despite advances in surgical technique and adjuvant treatment, endometrial cancer has recently seen an increase in incidence and mortality in the USA. The majority of endometrial cancers can be cured by surgery alone or in combination with adjuvant chemo- or radiotherapy; however, a subset of patients experience recurrence for reasons that remain unclear. Recurrence is associated with chemoresistance to carboplatin and paclitaxel and consequentially, high mortality. Understanding the pathways involved in endometrial cancer chemoresistance is paramount for the identification of biomarkers and novel molecular targets for this disease...
June 27, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29915882/androgen-receptor-and-ki67-expression-and-survival-outcomes-in-non-small-cell-lung-cancer
#5
Laurel Grant, Shantanu Banerji, Leigh Murphy, David E Dawe, Craig Harlos, Yvonne Myal, Zoann Nugent, Anne Blanchard, Carla R Penner, Gefei Qing, Marshall W Pitz
Lung cancer is the most common cause of cancer-related deaths worldwide with non-small cell lung cancer (NSCLC) making up most of these cases. Males have poorer overall survival compared to women following a lung cancer diagnosis. Many studies have focused on the effects of estrogen to explain higher survival rates among women, but few have looked at the effects of androgens. We describe the expression of the androgen receptor (AR) and Ki67 in lung cancer specimens in the Manitoba Tumor Bank (MTB) and correlate these factors with patient outcome...
June 18, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29948971/the-influence-of-menopausal-hormone-therapy-and-potential-lifestyle-interactions-in-female-cancer-development-a-population-based-prospective-study
#6
Marianne Holm, Anja Olsen, Cecilie Kyrø, Kim Overvad, Niels Kroman, Anne Tjønneland
The past decades have seen contradictory research results on the health benefits and risks of menopausal hormone therapy (HT). In particular, long-term associations with overall cancer incidence and the potential interplay with other lifestyle factors remain undetermined. In a population-based prospective cohort, 29,152 women aged 50-64 years at entry (1993-1997) were followed through 2013 for incidence of cancer (99% complete follow-up). Cox' proportional hazards models were used to estimate cancer incidence according to baseline HT alone and in combination with lifestyle factors including alcohol intake, BMI, physical activity, diet, and smoking...
June 14, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29948970/risk-analysis-of-prostate-cancer-treatments-in-promoting-metabolic-syndrome-development-and-the-influence-of-increased-metabolic-syndrome-on-prostate-cancer-therapeutic-outcome
#7
Zongping Chen, Jichun Deng, Yong Yan, Min Li, Chanjuan Chen, Chao Chen, Sicong Zhao, Tao Song, Tong Liu, Xin Wen, Yuhong Yao
In clinical practice, few prostate cancer (PCa) patients are associated with metabolic syndrome (MetS), while few others acquire MetS during treatment. Whether the treatment of PCa increases the occurrence of MetS remains to be confirmed. This study reviewed the changes in MetS patients before and after PCa treatment to evaluate the effects of various treatment methods on MetS. We analyzed data of 1162 PCa patients, whether or not diagnosed with MetS, and changes in MetS patients after PCa treatment. Data of lower urinary tract symptoms, C-reactive protein (CRP), platelet distribution width (PDW), prostate-specific antigen (PSA), Gleason score, clinical stage, treatment methods, and progressive incidents were evaluated using logistic regression according to MetS diagnosis...
June 9, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29736566/the-impact-of-esr1-mutations-on-the-treatment-of-metastatic-breast-cancer
#8
REVIEW
Sasha M Pejerrey, Derek Dustin, Jin-Ah Kim, Guowei Gu, Yassine Rechoum, Suzanne A W Fuqua
After nearly 20 years of research, it is now established that mutations within the estrogen receptor (ER) gene, ESR1, frequently occur in metastatic breast cancer and influence response to hormone therapy. Though early studies presented differing results, sensitive sequencing techniques now show that ESR1 mutations occur at a frequency between 20 and 40% depending on the assay method. Recent studies have focused on several "hot spot mutations," a cluster of mutations found in the hormone-binding domain of the ESR1 gene...
May 7, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29736565/the-flavonoid-apigenin-is-a-progesterone-receptor-modulator-with-in-vivo-activity-in-the-uterus
#9
Matthew Dean, Julia Austin, Ren Jinhong, Michael E Johnson, Daniel D Lantvit, Joanna E Burdette
Apigenin is a flavonoid with well-documented anti-cancer properties; however, its mechanisms of action are still unclear. We previously identified apigenin as a potential phytoprogestin, a natural product with a chemical scaffold that interacts with the progesterone receptor (PR). Our objective was to characterize the ability of apigenin to interact with PR through molecular docking studies, in vitro activity assays, and the ability of apigenin to elicit progestin-like effects in vivo. Molecular docking confirmed that apigenin could interact with PR, though with lower affinity than progesterone due to fewer van der Waals interactions...
May 7, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29687205/the-impact-of-hormonal-contraceptives-on-breast-cancer-pathology
#10
Jesse A Dorchak, Sifat Maria, Joseph L Guarinoni, Anette Duensing, Stella Somiari, Jane Cavanaugh, Brenda Deyarmin, Hai Hu, Joji Iida, Craig D Shriver, Paula A Witt-Enderby
This retrospective case series study, using data obtained through questionnaires and histopathological diagnoses from 656 patients enrolled in the Department of Defense (DoD) Clinical Breast Care Project (CBCP), evaluated associations between hormonal contraceptive use and breast cancer pathology including benign breast pathologies. Three combination hormonal contraceptive agents (COCs) Lo Ovral (LO), Ortho Novum (ON), and Ortho Tri-Cyclen (OTC) were evaluated as they represented the most commonly used hormonal contraceptives in our cohort...
April 23, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29603059/adiponectin-reverses-the-proliferative-effects-of-estradiol-and-igf-1-in-human-epithelial-ovarian-cancer-cells-by-downregulating-the-expression-of-their-receptors
#11
Marta Hoffmann, Justyna Gogola, Anna Ptak
The expression of adiponectin receptors AdipoR1 and AdipoR2 has been reported in the human ovary and ovarian cancer tissues. Moreover, adiponectin has been reported to act as an anti-tumor factor by inhibiting cancer cell proliferation. Thus, we investigate whether adiponectin and its receptors influence ovarian cancer development. In the present study, we found that adiponectin was not expressed in the granulosa cell line (COV434), and epithelial ovarian cancer cell lines (OVCAR-3, SKOV-3, and Caov-3). Additionally, we found that AdipoR1 and AdipoR2 expression is lower in epithelial ovarian cancer cells than in granulosa tumor cells...
June 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29556910/risk-of-second-primary-female-genital-malignancies-in-women-with-breast-cancer-a-seer-analysis
#12
Zhiyu Li, Qi Wu, Junlong Song, Yimin Zhang, Shan Zhu, Shengrong Sun
Breast cancer survivors are at an increased risk of second primary cancers, and the risk factors for the latter may have clinical significance. The aims of our study were to evaluate the incidences and risk factors of second primary female genital cancers (corpus uteri, cervix uteri plus ovary) in a large cohort of breast cancer survivors. Using the Surveillance, Epidemiology, and End Results (SEER) database, we examined the standardized incidence ratio (SIR) and risk factors for second primary female genital cancers observed between 2000 and 2014...
June 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29524179/type-1-igf-receptor-localization-in-paediatric-gliomas-significant-association-with-who-grading-and-clinical-outcome
#13
Florencia Clément, Ayelen Martin, Marcela Venara, Maria de Luján Calcagno, Cecilia Mathó, Silvana Maglio, Mercedes García Lombardi, Ignacio Bergadá, Patricia A Pennisi
Nuclear localization of insulin-like growth factor receptor type 1 (IGF-1R) has been described as adverse prognostic factor in some cancers. We studied the expression and localization of IGF-1R in paediatric patients with gliomas, as well as its association with World Health Organization (WHO) grading and survival. We conducted a single cohort, prospective study of paediatric patients with gliomas. Samples were taken at the time of the initial surgery; IGF-1R expression and localization were characterized by immunohistochemistry (IHC), subcellular fractionation and western blotting...
June 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29464548/leptin-involvement-in-primary-brain-and-pituitary-tumors-therapeutic-potential-prognostic-value-and-proposed-diagnostic-application
#14
REVIEW
Christos Bikis, Theodora Tzanavari, Krystallenia I Alexandraki, Stamatios Theocharis
Brain tumors are associated with increased mortality and morbidity and are the most common cancer type in children and young adults. The present review focuses on the interplay between leptin, the most extensively studied adipokine, and the onset, development, and treatment of primary brain and intracranial tumors. The two main mechanisms for increased leptin levels in intracranial tumor survivors, leptin resistance caused by hypothalamic damage, or secondary to obesity, are discussed. The contradicting mechanistic observations on leptin being able to both promote tumorinogenesis (e...
June 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29441459/thyroid-hormone-in-the-clinic-and-breast-cancer
#15
REVIEW
Aleck Hercbergs, Shaker A Mousa, Matthew Leinung, Hung-Yun Lin, Paul J Davis
There is preclinical and recent epidemiological evidence that thyroid hormone supports breast cancer. These observations raise the issue of whether management of breast cancer in certain settings should include consideration of reducing the possible contribution of thyroid hormone to the advancement of the disease. In a preliminary experience, elimination of the clinical action of endogenous L-thyroxine (T4 ) in patients with advanced solid tumors, including breast cancer, has favorably affected the course of the cancer, particularly when coupled with administration of exogenous 3,5,3'-triiodo-L-thyronine (T3 ) (euthyroid hypothyroxinemia)...
June 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29380230/thyroid-hormone-promotes-%C3%AE-catenin-activation-and-cell-proliferation-in-colorectal-cancer
#16
Yee-Shin Lee, Yu-Tang Chin, Ya-Jung Shih, André Wendindondé Nana, Yi-Ru Chen, Han-Chung Wu, Yu-Chen S H Yang, Hung-Yun Lin, Paul J Davis
Thyroid hormone status has long been implicated in cancer development. Here we investigated the role of thyroxine (T4 ) in colorectal cancer cell lines HCT 116 (APC wild type) and HT-29 (APC mutant), as well as the primary cultures of cancer cells derived from patients. Cell proliferation was evaluated with standard assay and proliferation marker expression. β-Catenin activation was examined according to nuclear β-catenin accumulation and β-catenin target gene expression. The results showed that T4 increased colorectal cancer cell proliferation while cell number and viability were elevated by T4 in both established cell lines and primary cells...
June 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29363091/combinatorial-effect-of-abiraterone-acetate-and-nvp-bez235-on-prostate-tumor-progression-in-rats
#17
Bianca Facchim Gonçalves, Silvana Gisele Pegorin de Campos, Wagner José Fávaro, Joyce Zalotti Brandt, Cristiane Figueiredo Pinho, Luis Antônio Justulin, Sebastião Roberto Taboga, Wellerson Rodrigo Scarano
Use of drug combinations that target different pathways involved in the development and progression of prostate cancer (PCa) has emerged as an alternative to overcome the resistance caused by drug monotherapies. The antiandrogen abiraterone acetate and the PI3K/Akt inhibitor NVP-BEZ235 (BEZ235) may be suitable options for the prevention of drug resistance and the inhibition of PCa progression. The aim of the present study was to evaluate whether abiraterone acetate and BEZ235 achieve superior therapeutic effects to either drug administered as monotherapy, in the early stages of PCa in an androgen-dependent system...
June 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29340908/fasting-blood-glucose-level-in-locally-advanced-non-small-cell-lung-cancer-a-new-prognostic-factor
#18
Esra Korkmaz Kirakli, Ufuk Yilmaz, Hasan Yilmaz, Berna Komurcuoglu
Hyperglycemia may lead to proliferation, invasion, apoptosis inhibition, migration, and eventually metastasis of cancer cells by several mechanisms. In this study, the effect of hyperglycemia on overall survival (OS), disease-free survival (DFS), and locoregional recurrence (LRR) was investigated in NSCLC. One stage IIIA-IIIB NSCLC patient treated with chemoradiotherapy between 2010 and 2015 was enrolled. Fasting blood glucose (FBG) levels were recorded in pre-treatment, treatment, and post-treatment periods...
June 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29417390/urban-neighborhood-and-residential-factors-associated-with-breast-cancer-in-african-american-women-a-systematic-review
#19
REVIEW
Brandi Patrice Smith, Zeynep Madak-Erdogan
Residential characteristics in urban neighborhoods impact health and might be important factors contributing to health disparities, especially in the African American population. The purpose of this systematic review is to understand the relationship between urban neighborhood and residential factors and breast cancer incidence and prognosis in African American women. Using PubMed and Web of Science, the existing literature was reviewed. Observational, cross-sectional, cohort, and prospective studies until February 2017 were examined...
April 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29363090/elevated-aromatase-cyp19a1-expression-is-associated-with-a-poor-survival-of-patients-with-estrogen-receptor-positive-breast-cancer
#20
Andrea Friesenhengst, Tamara Pribitzer-Winner, Heidi Miedl, Katharina Pröstling, Martin Schreiber
Genetic variants in CYP19A1, the gene encoding aromatase, have been reported to be associated with circulating estrogen concentrations, a key risk factor for breast cancer. The mechanism underlying this association is still unclear; it has been suggested that some of these variants may alter the expression and/or activity of aromatase. Here we analyzed the expression of intra-tumoral CYP19A1 messenger RNA (mRNA) and the genotypes of rs10046, a well-characterized single nucleotide polymorphism in CYP19A1, in 138 breast cancer patients and 15 breast cancer cell lines...
April 2018: Hormones & Cancer
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