Masateru Ono, Daiki Tenmaya, Maki Tarumi, Syouri Satou, Kotone Tsuji, Hirotaka Nishikawa, Shin Yasuda, Hiroyuki Miyashita, Jian-Rong Zhou, Kazumi Yokomizo, Hitoshi Yoshimitsu, Ryota Tsuchihashi, Masafumi Okawa, Junei Kinjo
Ipomoea muricata (L.) Jacq. seeds (Convolvulaceae) are used as a traditional laxative and carminative medicine. Muricatins XIV (1), XV (2), XVI (3), and XVII (4), were isolated from I. muricata seeds as four new resin glycosides, along with seven known compounds, three of which were isolated for the first time as natural products; their structures were determined using MS and NMR spectroscopy. Compounds 1-4 are macrolactones (jalapins); the sugar moieties of 1, 2, and 4 are partially acylated with 2S-methylbutyric acid, while that of 3 is esterified with 2S-methylbutyric and 2S-methyl-3S-hydroxybutyric acids...
March 8, 2024: Journal of Natural Medicines