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Journal of Natural Medicines

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https://www.readbyqxmd.com/read/28255848/iriomoteolides-9a-and-11a-two-new-odd-numbered-macrolides-from-the-marine-dinoflagellate-amphidinium-species
#1
Keiko Kumagai, Masayuki Tsuda, Eri Fukushi, Jun Kawabata, Atsunori Masuda, Masashi Tsuda
Iriomoteolides-9a (1) and 11a (2), new 15- and 19-membered macrolides, respectively, have been isolated from the marine dinoflagellate Amphidinium species (strain KCA09052). Compounds 1 and 2 were obtained from the extracts of the algal cells inoculated in the PES and TKF seawater medium, respectively. The structures of 1 and 2 were assigned on the basis of detailed NMR analyses. Compounds 1 and 2 exhibited cytotoxic activity against human cervix adenocarcinoma HeLa cells.
March 2, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28251520/chemical-structures-of-constituents-from-the-leaves-of-polyscias-balfouriana
#2
Sachiko Sugimoto, Yoshi Yamano, Hany Ezzat Khalil, Hideaki Otsuka, Mohamed Salah Kamel, Katsuyoshi Matsunami
A new pyrrolidine derivative, (5S)-hydroxyethyl 2-oxopyrrolidine-5-carboxylate (1), a new flavonol glycoside, tamaraxetin 3,7-di-O-α-L-rhamnopyranoside (2), and a new triterpene saponin, polyscioside A methyl ester (3), along with six known compounds (4-9) were isolated from the leaves of Polyscias balfouriana. Their chemical structures were elucidated on the basis of extensive spectroscopic analysis.
March 1, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28243817/two-new-secolignans-with-in-vitro-anti-inflammatory-activities-from-urtica-fissa-rhizomes
#3
Xiaoru Feng, Mengyue Wang, Jun Cheng, Xiaobo Li
Two new secolignans, urticin A (1) and urticin B (2), were isolated from the ethanol extract of Urtica fissa rhizomes. Their structures were elucidated on the basis of extensive spectroscopic evidence (UV, IR, HR-ESI-MS, and NMR). Urticin A and urticin B possessed in vitro anti-inflammatory activities, which significantly inhibited the TNF-α and NO release induced by LPS in RAW 264.7 cells.
February 27, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28220276/taxonomic-examination-of-longgu-fossilia-ossis-mastodi-dragon-bone-and-a-related-crude-drug-longchi-dens-draconis-dragon-tooth-from-japanese-and-chinese-crude-drug-markets
#4
Kazuki Oguri, Yuichiro Nishioka, Yoshitsugu Kobayashi, Kyoko Takahashi
Longgu ("dragon bone," Ryu-kotsu, Fossilia Ossis Mastodi, or Os Draconis) is the only fossil crude drug listed in the Japanese Pharmacopoeia. All longgu in the current Japanese market is imported from China, where its resources are being depleted. Therefore, effective countermeasures are urgently needed to prevent resource depletion. One possible solution is the development of a substitute made from bones of contemporary animals that are closely related to the original animal source of the current longgu. However, no research has been conducted on the original animal source of longgu, except for a report on the longgu specimens present in the Shosoin Repository...
February 20, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28205135/apium-graveolens-extract-influences-mood-and-cognition-in-healthy-mice
#5
Phetcharat Boonruamkaew, Wanida Sukketsiri, Pharkphoom Panichayupakaranant, Wijittra Kaewnam, Supita Tanasawet, Varomyalin Tipmanee, Pilaiwanwadee Hutamekalin, Pennapa Chonpathompikunlert
Apium graveolens is a food flavoring which possesses various health promoting effects. This study investigates the effect of a sub-acute administration of A. graveolens on cognition and anti-depression behaviors via antioxidant and related neurotransmitter systems in mice brains. Cognition and depression was assessed by various models of behavior. The antioxidant system of glutathione peroxidase (GPx), % inhibition of superoxide anion (O2(-)), and lipid peroxidation were studied. In addition, neurochemical parameters including acetylcholinesterase (AChE) and monoamine oxidase-type A (MAO-A) were also evaluated...
February 15, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28181079/anti-obesity-activity-of-yamabushitake-hericium-erinaceus-powder-in-ovariectomized-mice-and-its-potentially-active-compounds
#6
Eri Hiraki, Shoko Furuta, Rika Kuwahara, Naomichi Takemoto, Toshiro Nagata, Taiki Akasaka, Bungo Shirouchi, Masao Sato, Koichiro Ohnuki, Kuniyoshi Shimizu
Hericium erinaceus (H. erinaceus) improves the symptoms of menopause. In this study, using ovariectomized mice as a model of menopause, we investigated the anti-obesity effect of this mushroom in menopause. Mice fed diets containing H. erinaceus powder showed significant decreases in the amounts of fat tissue, plasma levels of total cholesterol, and leptin. To determine the mechanism, groups of mice were respectively fed a diet containing H. erinaceus powder, a diet containing ethanol extract of H. erinaceus, and a diet containing a residue of the extract...
February 8, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28181078/puerarin-may-protect-against-schwann-cell-damage-induced-by-glucose-fluctuation
#7
Bing Xue, Lin Wang, Zhe Zhang, Rui Wang, Xin-Xin Xia, Ping-Ping Han, Li-Jun Cao, Yong-Hui Liu, Lian-Qing Sun
Puerarin is one of the major active ingredients in Gegen, a traditional Chinese herb that has been reported to have a wide variety of beneficial pharmacology functions. Previous studies have implicated that the damaging effects of hyperglycemia resulting from oxidative stress and glucose fluctuation may be more dangerous than constant high glucose in the development of diabetes-related complications. The present study focuses on the effects of puerarin on glucose fluctuation-induced oxidative stress-induced Schwann cell (SC) apoptosis in vitro...
February 8, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28176233/inhibiting-reactive-oxygen-species-dependent-autophagy-enhanced-baicalein-induced-apoptosis-in-oral-squamous-cell-carcinoma
#8
Bo Li, Mei Lu, Xin-Xiang Jiang, Meng-Xiong Pan, Jun-Wu Mao, Mei Chen
Autophagy modulation has been considered a potential therapeutic strategy for oral squamous cell carcinoma (OSCC). A previous study confirmed that baicalein might possess significant anti-carcinogenic activity. However, whether baicalein induces autophagy and its role in cell death in OSCC are still unclear. The aim of this study was to investigate the anticancer activity and molecular targets of baicalein in OSCC in vitro. In this study, we found that baicalein induced significant apoptosis in OSCC cells Cal27...
February 7, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28150144/p-hydroxyacetophenone-suppresses-nuclear-factor-%C3%AE%C2%BAb-related-inflammation-in-nociceptive-and-inflammatory-animal-models
#9
Chang Ching-Wen, Chen Yun-Chieh, Lin Yu-Chin, Peng Wen-Huang
p-Hydroxyacetophenone (HAP) is a crucial chemical compound present in plants of the genus Artemisia, which are used in traditional therapies for treating jaundice, hepatitis, and inflammatory diseases. Nevertheless, the bioactivity of HAP remains to be identified in order to prove its importance in the plants of genus Artemisia. This study investigated the antioxidative, antinociceptive, and anti-inflammatory effects of HAP, and probed its possible molecular mechanisms. Our results revealed that HAP (80 mg/kg, intraperitoneally) in vivo reduced the acetic acid-induced writhing response and formalin-induced licking time...
February 1, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28110389/a-novel-lectin-from-artocarpus-lingnanensis-induces-proliferation-and-th1-th2-cytokine-secretion-through-cd45-signaling-pathway-in-human-t-lymphocytes
#10
Bo Cui, Lu Li, Qiyan Zeng, Faquan Lin, Lijun Yin, Liejun Liao, Min Huang, Jingping Wang
Lectins are carbohydrate-binding proteins and have been used for purification and characterization of glycoproteins. In this study, a novel 58.9-kDa tetrameric lectin from Artocarpus lingnanensis seeds was purified, characterized, and its mitogenic potential was evaluated. The hemagglutination inhibition assay indicated that Artocarpus lingnanensis lectin (ALL) showed specificity toward galactose. ALL was effectively purified in a single-step using affinity chromatography on a galactose-Sepharose column. ALL showed pH optima between 5...
January 21, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28105568/koumine-exhibits-anxiolytic-properties-without-inducing-adverse-neurological-effects-on-functional-observation-battery-open-field-and-vogel-conflict-tests-in-rodents
#11
Chao-Jie Chen, Zhi-Feng Zhong, Zhi-Ming Xin, Long-Hui Hong, Yan-Ping Su, Chang-Xi Yu
Koumine, an active alkaloid of neurotoxic plant Gelsemium, has been focused on its therapeutic uses, especially in central nervous system. Nevertheless, less is known about the neurological effects of koumine, which hampers its potential therapeutic exploitation. Moreover, as the anxiolytic potential of Gelsemium has raised many critical issues, its active principles on the anxiolytic and other neurological effects need to be further investigated. Here, we used functional observation battery (FOB) of mice to systematically measure the neurological effects of koumine at the effective doses, and then further confirmed its anxiolytic properties in open-field test (OFT) of mice and Vogel conflict test (VCT) of rats...
January 19, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28105567/effects-of-oleuropein-on-pentylenetetrazol-induced-seizures-in-mice-involvement-of-opioidergic-and-nitrergic-systems
#12
Nastaran Rahimi, Bahram Delfan, Nazgol Motamed-Gorji, Ahmad R Dehpour
Oleuropein, a well-known olive polyphenol, has been shown to mediate neuroprotection in Alzheimer's disease and cerebral ischemia. We investigated the effects of oleuropein on pentylenetetrazole (PTZ)-induced seizures in male NMRI mice, with diazepam as the standard drug. We also examined the possible involvement of opioidergic/nitrergic pathways in the probable effects of oleuropein. Intraperitoneal (i.p.) administration of different doses of oleuropein (10, 20 and 30 mg/kg) significantly increased the seizure threshold 60 min prior to induction of seizure, in a dose-dependent manner...
January 19, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28078535/tubulin-polymerization-stimulating-activity-of-ganoderma-triterpenoids
#13
Toshitaka Kohno, Tran Hai-Bang, Qinchang Zhu, Yhiya Amen, Seiichi Sakamoto, Hiroyuki Tanaka, Satoshi Morimoto, Kuniyoshi Shimizu
Tubulin polymerization is an important target for anticancer therapies. Even though the potential of Ganoderma triterpenoids against various cancer targets had been well documented, studies on their tubulin polymerization-stimulating activity are scarce. This study was conducted to evaluate the effect of Ganoderma triterpenoids on tubulin polymerization. A total of twenty-four compounds were investigated using an in vitro tubulin polymerization assay. Results showed that most of the studied triterpenoids exhibited microtuble-stabilizing activity to different degrees...
January 11, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28074433/partial-contribution-of-rho-kinase-inhibition-to-the-bioactivity-of-ganoderma-lingzhi-and-its-isolated-compounds-insights-on-discovery-of-natural-rho-kinase-inhibitors
#14
Yhiya Amen, Qinchang Zhu, Hai-Bang Tran, Mohamed S Afifi, Ahmed F Halim, Ahmed Ashour, Kuniyoshi Shimizu
Recent studies identified Rho-kinase enzymes (ROCK-I and ROCK-II) as important targets that are involved in a variety of diseases. Synthetic Rho-kinase inhibitors have emerged as potential therapeutic agents to treat disorders such as hypertension, stroke, cancer, diabetes, glaucoma, etc. Our study is the first to screen the total ethanol extract of the medicinal mushroom Ganoderma lingzhi with thirty-five compounds for Rho-kinase inhibitory activity. Moreover, a molecular binding experiment was designed to investigate the binding affinity of the compounds at the active sites of Rho-kinase enzymes...
January 10, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28074432/stereo-and-region-specific-biotransformation-of-physapubescin-by-four-fungal-strains
#15
Chongyue Qiu, Ting Yuan, Dejuan Sun, Suyu Gao, Lixia Chen
Biotransformations of physapubescin (1) were performed by four fungal strains-Mucor subtilissimus AS 3.2454, Mucor polymorphosporus AS 3.3443, Aspergillus niger AS 3.795, and Syncephalastrum racemosum AS 3.264. Four metabolites were prepared in the biotransformation process of 1, and their structures were elucidated as 15α-acetoxy-5,6β:22,26:24,25-triepoxy-26α-hydroxy-3β-methoxy 4β-hydroxyergost-1-one (2), 15α-acetoxy-5,6β:22,26-diepoxy-4β,24β,25α,26(α, β)-tetrahydroxyergost-3β-methoxy-1-one (3a/3b), 15α-acetoxy-5,6β:22,26-diepoxy-4β,24β,25α,26(α, β)-tetrahydroxyergost-2-en-1-one (4a/4b), and physapubescin D (5), by spectroscopic data analysis...
January 10, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28039567/lupinifolin-from-derris-reticulata-possesses-bactericidal-activity-on-staphylococcus-aureus-by-disrupting-bacterial-cell-membrane
#16
Kamol Yusook, Oratai Weeranantanapan, Yanling Hua, Pakarang Kumkrai, Nuannoi Chudapongse
In this study, lupinifolin, a prenylated flavonoid, was isolated from Derris reticulata stem, identified by NMR spectra and confirmed with mass spectrometry. Lupinifolin was freshly prepared by solubilizing in 0.1 N NaOH and immediately diluted in Müller-Hinton broth for antibacterial testing. The data showed that Gram-positive bacteria were more susceptible to lupinifolin than Gram-negative bacteria. Of four strains of Gram-positive bacteria tested, Staphylococcus aureus was the most susceptible. Using the two-fold microdilution method, it was found that lupinifolin possessed antimicrobial activity against S...
December 30, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27866320/protein-tyrosine-phosphatase-1b-inhibitory-properties-of-seco-cucurbitane-triterpenes-obtained-from-fruiting-bodies-of-russula-lepida
#17
Wilmar Maarisit, Hiroyuki Yamazaki, Syu-Ichi Kanno, Ayako Tomizawa, Jong-Soo Lee, Michio Namikoshi
The known seco-cucurbitane triterpene, (24E)-3,4-seco-cucurbita-4,24-diene-3,26,29-trioic acid (1), has been isolated as a potent protein tyrosine phosphatase (PTP) 1B inhibitor together with a new analogue, (24E)-3,4-seco-cucurbita-4,24-diene-3-hydroxy-26,29-dioic acid (2), from the fruiting bodies of Russula lepida. Further evaluation of their biological properties against PTPs revealed that compound 1 inhibited T-cell PTP activity similarly to PTP1B and exhibited moderate selectivity against PTP1B over vaccinia H-1-related phosphatase...
January 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27858308/gastroprotective-effect-of-palmatine-against-acetic-acid-induced-gastric-ulcers-in-rats
#18
Ling Wang, Xue Wang, Su-Li Zhang, Xiao-Ming Zhu, Yan-Qi Liu, Zi-Jing Song, Wen-Juan Du, Jun Ji, Cheng-Long Cui, Xin He, Chun-Feng Zhang, Chang-Run Guo, Chong-Zhi Wang, Chun-Su Yuan
Gastric ulcers are one of the most common gastrointestinal disorders. The aim of this study was to investigate the gastroprotective activity and possible underlying mechanisms of palmatine against acetic acid-induced gastric ulcers in rats. Palmatine was administered orally for 7 consecutive days to treat ulcers. The ulcer area, ulcer inhibition rate, histological section, platelet-activating factor (PAF) level in serum, prostaglandin E2 (PGE2) level in gastric tissue, 5-hydroxytryptamine (5-HT) level in the brain and norepinephrine (NE) level in the adrenal glands were analyzed...
January 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27848205/evaluation-of-the-safety-and-efficacy-of-glycyrrhiza-uralensis-root-extracts-produced-using-artificial-hydroponic-and-artificial-hydroponic-field-hybrid-cultivation-systems
#19
H Akiyama, M Nose, N Ohtsuki, S Hisaka, H Takiguchi, A Tada, N Sugimoto, H Fuchino, T Inui, N Kawano, S Hayashi, A Hishida, T Kudo, K Sugiyama, Y Abe, M Mutsuga, N Kawahara, K Yoshimatsu
Glycyrrhiza uralensis roots used in this study were produced using novel cultivation systems, including artificial hydroponics and artificial hydroponic-field hybrid cultivation. The equivalency between G. uralensis root extracts produced by hydroponics and/or hybrid cultivation and a commercial Glycyrrhiza crude drug were evaluated for both safety and efficacy, and there were no significant differences in terms of mutagenicity on the Ames tests. The levels of cadmium and mercury in both hydroponic roots and crude drugs were less than the limit of quantitation...
January 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27848204/securigenin-glycosides-as-hypoglycemic-principles-of-securigera-securidaca-seeds
#20
Zahra Tofighi, Fahimeh Moradi-Afrapoli, Samad Nejad Ebrahimi, Saied Goodarzi, Abbas Hadjiakhoondi, Markus Neuburger, Matthias Hamburger, Mohammad Abdollahi, Narguess Yassa
Seeds of Securigera securidaca (Fabaceae) are used in Iranian folk medicine as an antidiabetic treatment. In this study, the antihyperglycemic activity of chloroform and methanol fractions (CF and MF) from S. securidaca seed extract was investigated and their bioactive constituents were identified. The antidiabetic effects of fractions were assessed by streptozocin-induced diabetic Naval Medical Research Institute mice. The hypoglycemic activity of MF at 100 mg/kg and CF at 400 mg/kg was comparable with glibenclamide (3 mg/kg)...
January 2017: Journal of Natural Medicines
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