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Journal of Natural Medicines

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https://www.readbyqxmd.com/read/27915399/naringenin-interferes-with-the-anti-diabetic-actions-of-pioglitazone-via-pharmacodynamic-interactions
#1
Hiroki Yoshida, Rika Tsuhako, Toshiyuki Atsumi, Keiko Narumi, Wataru Watanabe, Chihiro Sugita, Masahiko Kurokawa
Pioglitazone is a peroxisome proliferator-activated receptor gamma (PPARγ) full agonist and useful for the treatment of type 2 diabetes mellitus. Naringenin is a citrus flavonoid with anti-inflammatory actions, which has been shown to prevent obesity-related diseases and to activate PPARγ. The aim of this study was to investigate whether dietary naringenin affects the actions of pioglitazone. We administered naringenin (100 mg/kg) and pioglitazone (10 mg/kg) to Tsumura Suzuki Obese Diabetes (TSOD) mice for 4 weeks and then conducted an oral glucose tolerance test...
December 3, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27900596/pharmacological-evaluation-for-improvement-of-kanazawa-sutra-medicinal-thread-for-anal-fistula
#2
Takami Yokogawa, Yohei Sasaki, Hirokazu Ando, Katsuya Yamamoto, Masayuki Mikage
Kanazawa Sutra (KanS) is a medicinal thread that is used for the treatment of anal fistula. It is used as a substitute for Kshara Sutra (KS) which is used in Ayurvedic medicine. KanS is composed of Ficus carica latex (FCL), Capsicum annuum tincture (CAT), Achyranthes fauriei Kshara (which is processed ash from the whole plant) and powdered Curcuma longa rhizome (CLR). In this study, we evaluated the ingredients of KanS by measuring nitric oxide (NO) production in murine macrophage-like cell line J774.1 as well as examining cytotoxicity to rat skeletal muscle myoblasts (L6) and L6 differentiation, with a view to improving its pharmacological effect...
November 29, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27866320/protein-tyrosine-phosphatase-1b-inhibitory-properties-of-seco-cucurbitane-triterpenes-obtained-from-fruiting-bodies-of-russula-lepida
#3
Wilmar Maarisit, Hiroyuki Yamazaki, Syu-Ichi Kanno, Ayako Tomizawa, Jong-Soo Lee, Michio Namikoshi
The known seco-cucurbitane triterpene, (24E)-3,4-seco-cucurbita-4,24-diene-3,26,29-trioic acid (1), has been isolated as a potent protein tyrosine phosphatase (PTP) 1B inhibitor together with a new analogue, (24E)-3,4-seco-cucurbita-4,24-diene-3-hydroxy-26,29-dioic acid (2), from the fruiting bodies of Russula lepida. Further evaluation of their biological properties against PTPs revealed that compound 1 inhibited T-cell PTP activity similarly to PTP1B and exhibited moderate selectivity against PTP1B over vaccinia H-1-related phosphatase...
November 19, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27858308/gastroprotective-effect-of-palmatine-against-acetic-acid-induced-gastric-ulcers-in-rats
#4
Ling Wang, Xue Wang, Su-Li Zhang, Xiao-Ming Zhu, Yan-Qi Liu, Zi-Jing Song, Wen-Juan Du, Jun Ji, Cheng-Long Cui, Xin He, Chun-Feng Zhang, Chang-Run Guo, Chong-Zhi Wang, Chun-Su Yuan
Gastric ulcers are one of the most common gastrointestinal disorders. The aim of this study was to investigate the gastroprotective activity and possible underlying mechanisms of palmatine against acetic acid-induced gastric ulcers in rats. Palmatine was administered orally for 7 consecutive days to treat ulcers. The ulcer area, ulcer inhibition rate, histological section, platelet-activating factor (PAF) level in serum, prostaglandin E2 (PGE2) level in gastric tissue, 5-hydroxytryptamine (5-HT) level in the brain and norepinephrine (NE) level in the adrenal glands were analyzed...
November 17, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27848205/evaluation-of-the-safety-and-efficacy-of-glycyrrhiza-uralensis-root-extracts-produced-using-artificial-hydroponic-and-artificial-hydroponic-field-hybrid-cultivation-systems
#5
H Akiyama, M Nose, N Ohtsuki, S Hisaka, H Takiguchi, A Tada, N Sugimoto, H Fuchino, T Inui, N Kawano, S Hayashi, A Hishida, T Kudo, K Sugiyama, Y Abe, M Mutsuga, N Kawahara, K Yoshimatsu
Glycyrrhiza uralensis roots used in this study were produced using novel cultivation systems, including artificial hydroponics and artificial hydroponic-field hybrid cultivation. The equivalency between G. uralensis root extracts produced by hydroponics and/or hybrid cultivation and a commercial Glycyrrhiza crude drug were evaluated for both safety and efficacy, and there were no significant differences in terms of mutagenicity on the Ames tests. The levels of cadmium and mercury in both hydroponic roots and crude drugs were less than the limit of quantitation...
November 15, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27848204/securigenin-glycosides-as-hypoglycemic-principles-of-securigera-securidaca-seeds
#6
Zahra Tofighi, Fahimeh Moradi-Afrapoli, Samad Nejad Ebrahimi, Saied Goodarzi, Abbas Hadjiakhoondi, Markus Neuburger, Matthias Hamburger, Mohammad Abdollahi, Narguess Yassa
Seeds of Securigera securidaca (Fabaceae) are used in Iranian folk medicine as an antidiabetic treatment. In this study, the antihyperglycemic activity of chloroform and methanol fractions (CF and MF) from S. securidaca seed extract was investigated and their bioactive constituents were identified. The antidiabetic effects of fractions were assessed by streptozocin-induced diabetic Naval Medical Research Institute mice. The hypoglycemic activity of MF at 100 mg/kg and CF at 400 mg/kg was comparable with glibenclamide (3 mg/kg)...
November 15, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27830412/nobiletin-improves-emotional-and-novelty-recognition-memory-but-not-spatial-referential-memory
#7
Jiyun Kang, Jung-Won Shin, Yoo-Rim Kim, Kelley M Swanberg, Yooseung Kim, Jae Ryong Bae, Young Ki Kim, Jinwon Lee, Soo-Yeon Kim, Nak-Won Sohn, Sungho Maeng
How to maintain and enhance cognitive functions for both aged and young populations is a highly interesting subject. But candidate memory-enhancing reagents are tested almost exclusively on lesioned or aged animals. Also, there is insufficient information on the type of memory these reagents can improve. Working memory, located in the prefrontal cortex, manages short-term sensory information, but, by gaining significant relevance, this information is converted to long-term memory by hippocampal formation and/or amygdala, followed by tagging with space-time or emotional cues, respectively...
November 9, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27812785/evaluation-of-the-chemical-quality-of-sekkoku-in-current-japanese-commercial-crude-drugs-constituents-of-flickingeria-xantholeuca-rchb-f-a-d-hawkes
#8
Mei Muto, Haruka Asahina, Tatsufumi Yoshioka, Kazuo Ozaki, Makio Shibano
In our investigation, most Shihu (; Japanese name, Sekkoku) in current Japanese commercial crude drugs were from Flickingeria xantholeuca (Orchidaceae). As the index compounds, three new ent-pimarane-type diterpenes, flickinxthanthosides A-C (1-3), one known analogue (7), and three new ent-kaurane-type diterpenes, flickinxanthosides D (4) and E (5) and flickinxanthol A (6) were isolated from the stem of F. xantholeuca. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and chemical methods...
November 3, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27771849/hypocholesterolemic-effect-of-sericin-derived-oligopeptides-in-high-cholesterol-fed-rats
#9
Phakhamon Lapphanichayakool, Manote Sutheerawattananonda, Nanteetip Limpeanchob
The beneficial effect of cholesterol-lowering proteins and/or peptides derived from various dietary sources is continuously reported. A non-dietary protein from silk cocoon, sericin, has also demonstrated cholesterol-lowering activity. A sericin hydrolysate prepared by enzymatic hydrolysis was also expected to posses this effect. The present study was aimed at investigating the cholesterol-lowering effect of sericin peptides, so called "sericin-derived oligopeptides" (SDO) both in vivo and in vitro. The results showed that SDO at all three doses tested (10 mg kg(-1) day(-1), 50 mg kg(-1) day(-1), and 200 mg kg(-1) day(-1)) suppressed serum total and non-HDL cholesterol levels in rats fed a high-cholesterol diet...
October 22, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27771848/hypouricemic-effect-of-flaccidoside-ii-in-rodents
#10
Guo-Bin Zhang, Shan-Shan Ren, Bao-Ying Wang, Lian-Qi Tian, Fei-Hong Bing
To investigate the effect of flaccidoside II on the serum uric acid levels in hyperuricemic rodents. Both mice and rats were injected intraperitoneally with potassium oxonate to induce hyperuricemia. Different dosages of flaccidoside II were orally administrated to hyperuricemic and normal rodents for 7 days, respectively. Liver xanthine oxidase (XOD) activities in hyperuricemic mice were determined using the colorimetric method. Acute toxicity of flaccidoside II was also evaluated in mice. Allopurinol, as a positive control, was administered under the same treatment scheme...
October 22, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27770304/involvement-of-monoaminergic-systems-in-anxiolytic-and-antidepressive-activities-of-the-standardized-extract-of-cocos-nucifera-l
#11
Eliane Brito Cortez Lima, Caren Nádia Soares de Sousa, Lucas Nascimento Meneses, Yuri Freitas E Silva Pereira, Natália Castelo Branco Matos, Rayanne Brito de Freitas, Nycole Brito Cortez Lima, Manoel Cláudio Azevedo Patrocínio, Luzia Kalyne Almeida Moreira Leal, Glauce Socorro Barros Viana, Silvânia Maria Mendes Vasconcelos
Extracts from the husk fiber of Cocos nucifera are used in folk medicine, but their actions on the central nervous system have not been studied. Here, the anxiolytic and antidepressant effects of the standardized hydroalcoholic extract of C. nucifera husk fiber (HECN) were evaluated. Male Swiss mice were treated with HECN (50, 100, or 200 mg/kg) 60 min before experiments involving the plus maze test, hole-board test, tail suspension test, and forced swimming test (FST). HECN was administered orally (p.o.) in acute and repeated-dose treatments...
October 21, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27766480/aged-garlic-extract-suppresses-platelet-aggregation-by-changing-the-functional-property-of-platelets
#12
Naoaki Morihara, Atsuko Hino
Aged garlic extract (AGE), a garlic preparation rich in water-soluble cysteinyl moieties, has been reported to have multiple beneficial effects on cardiovascular disease including inhibition of platelet aggregation. However, the mode of AGE action on platelets has not been clear. In this study, we examined the effect of AGE on the functional property of platelet by administering AGE to rats and evaluating the platelet aggregation in response to collagen in vitro. We found that AGE treatment significantly reduced the ability of platelet to aggregate and this effect of AGE was manifested on the 14 day, but not 7 day of treatment...
October 20, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27761694/chodatiionosides-a-and-b-two-new-megastigmane-glycosides-from-chorisia-chodatii-leaves
#13
Mamdouh Nabil Samy, John Refaat Fahim, Sachiko Sugimoto, Hideaki Otsuka, Katsuyoshi Matsunami, Mohamed Salah Kamel
Phytochemical investigation of Chorisia chodatii Hassl. leaves led to the isolation of an unusual rearranged megastigmane glycoside; chodatiionoside A (1) and another new megastigmane glycoside; chodatiionoside B (2), together with three known megastigmane glycosides (3-5) and one known flavonoid glycoside (6). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments ((1)H, (13)C, DEPT, COSY, HSQC and HMBC) in combination with HR-ESI-MS, CD and modified Mosher's method. As a result, chodatiionoside A has been elucidated as a first example of an unusual rearranged form of megastigmane...
October 19, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27747446/the-effects-of-18%C3%AE-glycyrrhetinic-acid-and-glycyrrhizin-on-intestinal-absorption-of-paeoniflorin-using-the-everted-rat-gut-sac-model
#14
Rui He, Yongsong Xu, Jingjing Peng, Tingting Ma, Jing Li, Muxin Gong
Paeoniflorin (PF), the main active component of Shaoyao-Gancao-tang, possesses significantly antinociceptive effects and many other pharmacological activities. However, its poor intestinal absorption results in low bioavailability. Therefore, enhancing PF absorption plays a vital role in exerting its therapeutic effect. Shaoyao combined with Gancao exhibited a synergistic effect. The enhancement of PF absorption through the interaction of its constituents in intestinal absorption would be greatly implicated...
October 17, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27738860/mangostanaxanthones-iii-and-iv-advanced-glycation-end-product-inhibitors-from-the-pericarp-of-garcinia-mangostana
#15
Hossam M Abdallah, Hany M El-Bassossy, Gamal A Mohamed, Ali M El-Halawany, Khalid Z Alshali, Zainy M Banjar
Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, atherosclerosis, retinopathy, neuropathy, and Alzheimer's disease. Garcinia mangostana L. (Clusiaceae) (GM) was selected owing to the ability of its polar and non-polar fractions to inhibit AGE formation...
October 13, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27738859/screening-of-promising-chemotherapeutic-candidates-from-plants-against-human-adult-t-cell-leukemia-lymphoma-v-coumarins-and-alkaloids-from-boenninghausenia-japonica-and-ruta-graveolens
#16
Daisuke Nakano, Kenji Ishitsuka, Narumi Matsuda, Ai Kouguchi, Ryota Tsuchihashi, Masafumi Okawa, Hikaru Okabe, Kazuo Tamura, Junei Kinjo
During the course of our studies towards the identification of promising chemotherapeutic candidates from plants against two human T-cell lymphotropic virus type I-infected T-cell lines (MT-1 and MT-2), we screened 17 extracts from 9 rutaceous plants against MT-1 and MT-2 cells. The extracts from the aerial parts and roots of Boenninghausenia japonica, as well as the leaves and roots of Ruta graveolens showed potent antiproliferative effects. After activity-guided fractionation, we isolated 44 compounds from two rutaceous plants, including three new compounds (1-3), which were classified into 26 coumarin analogs (13 coumarins, 8 furanocoumarins, 4 dihydrofuranocoumarins and one dihydropyranocoumarin), 15 alkaloid analogs (7 quinolone alkaloids, 4 acridone alkaloids, 3 furanoquinoline alkaloids and one tetrahydroacridone alkaloid) and 3 flavonoid glycosides...
October 13, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27709321/lignans-from-guaiac-resin-decrease-nitric-oxide-production-in-interleukin-1%C3%AE-treated-hepatocytes
#17
Yuki Nakano, Masaaki Nasu, Mana Kano, Hiroshi Kameoka, Tetsuya Okuyama, Mikio Nishizawa, Yukinobu Ikeya
Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1β (IL-1β). Six lignans were purified from guaiac resin and identified as: dehydroguaiaretic acid (1), (+)-trans-1,2-dihydrodehydroguaiaretic acid (2), furoguaiaoxidin (3), meso-dihydroguaiaretic acid (4), furoguaiacin (i...
October 5, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27680541/carbazole-alkaloids-from-murraya-koenigii-trigger-apoptosis-and-autophagic-flux-inhibition-in-human-oral-squamous-cell-carcinoma-cells
#18
Tanyarath Utaipan, Anan Athipornchai, Apichart Suksamrarn, Canussanun Jirachotikoon, Xiaohong Yuan, Monthon Lertcanawanichakul, Warangkana Chunglok
Carbazole alkaloids, a major constituent of Murraya koenigii (L.) Sprengel (Rutaceae), exhibit biological effects such as anticancer activity via the induction of apoptosis, and they represent candidate chemotherapeutic agents. Oral squamous cell carcinoma (OSCC) is the most prevalent cancer of the oral cavity and a growing and serious health problem worldwide. In this study, we investigated the anticancer properties and mechanisms of action of two carbazole alkaloids derived from M. koenigii leaves, mahanine and isomahanine, in the OSCC cell line CLS-354...
September 28, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27665609/quantitative-evaluation-and-discrimination-of-wild-paris-polyphylla-var-yunnanensis-franch-hand-mazz-from-three-regions-of-yunnan-province-using-uhplc-uv-ms-and-uv-spectroscopy-couple-with-partial-least-squares-discriminant-analysis
#19
Yuangui Yang, Hang Jin, Ji Zhang, Jinyu Zhang, Yuanzhong Wang
Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz (PPY) is used widely as an anthelmintic, antimicrobial, and anti-tumor agent. Multiplicate analytical methods have been employed to discriminate PPY from different regions, as well as to identify regions most beneficial to the growing of this species. In this study, a convenient and accurate method was established using ultra high performance liquid chromatography (UHPLC) for simultaneous determination of four steroid saponins (Pa, Pb, polyphyllin VI, and chonglou saponin VII)...
September 24, 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27665608/rapid-and-simple-determination-of-polyphyllin-i-ii-vi-and-vii-in-different-harvest-times-of-cultivated-paris-polyphylla-smith-var-yunnanensis-franch-hand-mazz-by-uplc-ms-ms-and-ft-ir
#20
Zhe Wu, Ji Zhang, Furong Xu, Yuanzhong Wang, Jinyu Zhang
Paris Polyphylla Smith var. yunnanensis (Franch.) Hand.-Mazz ("Dian Chonglou" in Chinese) is a famous herbal medicine in China, which is usually well known for activities of anti-cancer, hemolysis, and cytotoxicity. In this study, Fourier transform infrared (FT-IR) spectroscopy coupled with principal component analysis (PCA) and partial least-squares regression (PLSR) was applied to discriminate samples of P. polyphylla var. yunnanensis harvested in different years and determine the content of polyphyllin I, II, VI, and VII in P...
September 24, 2016: Journal of Natural Medicines
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