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Journal of Natural Medicines

Pornsiri Pitchakarn, Sonthaya Umsumarng, Sariya Mapoung, Pisamai Ting, Piya Temviriyanukul, Wanisa Punfa, Wilart Pompimon, Pornngarm Limtrakul
We previously reported the multidrug resistance-reversing ability of kuguacin J (KJ) in cervical cancer cells via the inhibition of P-glycoprotein (P-gp) function. This study investigated whether KJ could promote cisplatin- and paclitaxel (PTX)-induced cancer cell death in drug-resistance human ovarian cancer cells (SKOV3). Cytotoxicity testing showed that SKOV3 was more resistant to cisplatin and PTX compared to drug-sensitive human ovarian cancer cells (A2780). The cytotoxicity of PTX was significantly increased in SKOV3 cells when co-treated with KJ...
June 21, 2017: Journal of Natural Medicines
Jiankun Yan, Xuliu Shi, Paul Owusu Donkor, Huajie Zhu, Xiumei Gao, Liqin Ding, Feng Qiu
Nine pairs of megastigmane enantiomers (1a/1b-9a/9b), comprising two new compounds (6S,9R)-blumenol C (7b), (6S,9S)-blumenol C (8b), two pairs of enantiomers (+)-(6R)-eucomegastigmane A (1a), (-)-(6S)-eucomegastigmane A (1b), (+)-(3S,4S)-eucomegastigmane B (5a), (-)-(3R,4R)-eucomegastigmane B (5b) isolated by chiral resolution firstly, and twelve known compounds, were isolated from the leaves of Eucommia ulmoides Oliver. Their structures were elucidated based on extensive spectroscopic analysis. Absolute configurations of the megastigmane enantiomers were assigned by comparing experimental ECD and OR with calculated ECD and OR...
June 20, 2017: Journal of Natural Medicines
Madan Kumar Paudel, Seiichi Sakamoto, Hiroyuki Tanaka, Satoshi Morimoto
Wogonin glucuronide (wogonin 7-O-β-D-glucuronide, Wgn) is widely recognized as a constituent of Scutellariae radix, which is used in Kampo medicines. Wgn has been used for both pharmacological (antifebrile uses and in detoxification) and research purposes. A recombinant antigen-binding fragment (rFab) and an antigen-binding fragment from a monoclonal antibody (mFab) against Wgn were constructed and used in an indirect competitive enzyme-linked immunosorbent assay (icELISA) in this study. The rFab and mFab against Wgn showed both activity and recognition against Wgn...
June 16, 2017: Journal of Natural Medicines
Mitsuhiko Nose, Momoka Tada, Rika Kojima, Kumiko Nagata, Shinsuke Hisaka, Sayaka Masada, Masato Homma, Takashi Hakamatsuka
Glycyrrhizae Radix is the most frequently used crude drug in Japan and is prescribed in Kampo medicine for the treatment of a wide range of diseases. The major active ingredient of Glycyrrhizae Radix, glycyrrhizin (GL), has been shown to possess various pharmacological actions, but is also known to cause adverse effects such as pseudoaldosteronism. To avoid the adverse effects of GL, precautions have been indicated on the package inserts of Glycyrrhizae Radix-containing formulas depending on the amount of Glycyrrhizae Radix they contain...
June 12, 2017: Journal of Natural Medicines
Thanchanok Puksasook, Shinya Kimura, Sarin Tadtong, Jutamas Jiaranaikulwanitch, Jaturong Pratuangdejkul, Worawan Kitphati, Khanit Suwanborirux, Naoki Saito, Veena Nukoolkarn
A series of prenylated resveratrol derivatives were designed, semisynthesized and biologically evaluated for inhibition of β-secretase (BACE1) and amyloid-β (Aβ) aggregation as well as free radical scavenging and neuroprotective and neuritogenic activities, as potential novel multifunctional agents against Alzheimer's disease (AD). The results showed that compound 4b exhibited good anti-Aβ aggregation (IC50 = 4.78 µM) and antioxidant activity (IC50 = 41.22 µM) and moderate anti-BACE1 inhibitory activity (23...
June 9, 2017: Journal of Natural Medicines
Toru Takahashi, Aya Okiura, Masahiro Kohno
The leaves of fig (Ficus carica L.) have been used for traditional and Chinese medicine. We determined the composition of phenylpropanoids (polyphenols and furanocoumarins) as a functional agent in the leaves of 37 cultivars of fig. The most abundant polyphenol was caffeoylmalic acid (12.0-26.6 mg/g dry weight), followed by rutin (4.7-14.6 mg/g dry weight) and isoschaftoside (2.5-6.4 mg/g dry weight). Psoralen (3.8-23.0 mg/g dry weight) was dominant in the furanocoumarins. In molar amounts, psoralic acid glucoside (PAG), a precursor of psoralen, was equivalent to psoralen...
June 6, 2017: Journal of Natural Medicines
Tharita Kitisripanya, Chadathorn Inyai, Jukrapun Komaikul, Supaluk Krittanai, Thaweesak Juengwatanatrakul, Seiichi Sakamoto, Hiroyuki Tanaka, Satoshi Morimoto, Waraporn Putalun
White Kwao Krua (WKK)-derived products have been used worldwide as dietary supplements to relieve climacteric symptoms in menopausal women. Miroestrol is a unique chromene found in WKK tuberous roots that corresponds to the estrogenic activity of WKK. However, miroestrol naturally accumulates at low levels in WKK samples, which are difficult to detect. The development of a rapid and sensitive assay to detect miroestrol in numerous products derived from this plant would be a practical and useful method to guarantee the quality of raw materials...
June 1, 2017: Journal of Natural Medicines
Janar Jenis, Jeong Yoon Kim, Zia Uddin, Yeong Hun Song, Hyeong-Hwan Lee, Ki Hun Park
Members of the genus Limonium are widely used as medicinal herbs due to their health-promoting effects, such as an ability to improve blood circulation by inhibiting angiotensin I converting enzyme (ACE). While the potential of L. michelsonii Lincz. (a medicinal plant endemic to Kazakhstan) to inhibit ACE has been demonstrated, the inhibitory activities of its secondary metabolites have not been explored. In this work, the principal phenolic compounds (1-20) among these metabolites were isolated to determine the components responsible for ACE inhibition...
May 26, 2017: Journal of Natural Medicines
CuiCui Jia, Tong Han, Jun Xu, ShengGe Li, YaTing Sun, DaHong Li, ZhanLin Li, HuiMing Hua
A new biflavonoid, paucinervin K (1) and a new triterpene, 23-hydroxy-friedelin (2), together with eleven known compounds 3-13 were isolated from the leaves of Garcinia paucinervis. Their structures, including stereochemistry, were determined by spectroscopic analysis of NMR, MS, IR and ECD calculation and the octant rule. Some of the isolated compounds were tested for antiproliferative, α-glucosidase inhibitory and antioxidant activities in vitro. Compounds 1, 3, 4, 5 and 9 showed moderate preferential antioxidant and hypoglycemic activities...
May 26, 2017: Journal of Natural Medicines
Deiske A Sumilat, Hiroyuki Yamazaki, Kotaro Endo, Henki Rotinsulu, Defny S Wewengkang, Kazuyo Ukai, Michio Namikoshi
A new biphenyl ether derivative, 2-hydroxy-6-(2'-hydroxy-3'-hydroxymethyl-5-methylphenoxy)-benzoic acid (1), was isolated together with the known benzophenone derivative, monodictyphenone (2), from a culture broth of Indonesian ascidian-derived Penicillium albobiverticillium TPU1432 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of 1 was elucidated based on NMR experiments. Compound 2 exhibited moderate inhibitory activities against protein tyrosine phosphatase (PTP) 1B, T cell PTP (TCPTP), and CD45 tyrosine phosphatase (CD45), whereas compound 1 modestly inhibited CD45 activity...
May 26, 2017: Journal of Natural Medicines
Koji Fujihara, Kunio Takahashi, Kiyotaka Koyama, Kaoru Kinoshita
Five new oleanane-type saponins 1-5 together with a known saponin 6 and a steroidal glycoside 7 were isolated from Polaskia chichipe Backbg., and their structures were determined from their 1D and 2D NMR and HRFABMS spectral data. The six isolated saponins 1-6 were tested for their effects on the melanogenesis of B16 melanoma 4A5 cells. Compound 1 exerted an inhibitory effect at 100 μM whereas compound 3 promoted melanogenesis at the same concentration, even though these two compounds contain the same aglycon structure...
May 11, 2017: Journal of Natural Medicines
Ichiro Kawahata, Tatsuya Suzuki, Evelyn Gutiérrez Rico, Shuichi Kusano, Hiroshi Tamura, Yoshihiro Mimaki, Tohru Yamakuni
A previous study reported biotransformation of a citrus peel polymethoxyflavone, nobiletin, by Aspergillus enabling production of 4'-demethylnobiletin, and the product's antimutagenic activity. However, the effects of fermented citrus peel on the basal forebrain-hippocampal system remain unidentified. Citrus reticulata (ponkan) fruit squeezed draffs are generated as mass waste in beverage factories. In this study using PC12D cells and cultured central nervous system neurons, we therefore examined whether Aspergillus kawachii-fermented citrus fruit squeezed draff could affect cAMP response element (CRE)- and choline acetyltransferase gene (ChAT) promoter region-mediated transcriptional activities relevant to memory formation and cholinergic function...
May 9, 2017: Journal of Natural Medicines
Ahmed H El-Desoky, Hikaru Kato, Sachiko Tsukamoto
Three new spongian diterpenes, ceylonins G-I (1-3), were isolated from the marine sponge Spongia ceylonensis collected in Indonesia, together with five known spongian diterpenes (4-8). Only 4 inhibited USP7 with an IC50 value of 8.2 μM.
May 3, 2017: Journal of Natural Medicines
Fusako Nakano, Shozo Miyoshi, Toshiyuki Murakami
Four new galloyl-oxygen-diphenyl (GOD)-type ellagitannins, brambliins A-D (1-4), were isolated from the leaves of Rubus suavissimus. Their structures were elucidated by extensive spectroscopic analyses and the absolute configurations of 1-4 were determined by chemical and phytochemical evidence. These GOD-type ellagitannins inhibited the formation of dental plaque, which is beneficial for oral hygiene.
July 2017: Journal of Natural Medicines
Parinuch Chumkaew, Jaraslak Pechwang, Theera Srisawat
Phytochemical investigation of the stems from Brucea javanica led to the isolation of two new quassinoids, brujavanol C (1) and brujavanol D (2), together with six known compounds (3-8). The chemical structures were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum and compounds 6 and 7 exhibited the most potent activity against the K1 strain, with IC50 values of 1.41 and 1.06 μM, respectively.
July 2017: Journal of Natural Medicines
Saeed Amiri Gheshlaghi, Razieh Mohammad Jafari, Mohammad Algazo, Nastaran Rahimi, Hussein Alshaib, Ahmad Reza Dehpour
Genistein, a major source of phytoestrogen exposure for humans and animals, has been shown to mediate neuroprotection in Alzheimer's disease and status epilepticus. In the present study, we investigated the effect of genistein on pentylenetetrazole-induced seizures in ovariectomized mice and the possible involvement of estrogenic and serotonergic pathways in the probable effects of genistein. Intraperitoneal (i.p.) administration of genistein (10 mg/kg) significantly increased the seizure threshold 30 min prior to induction of seizures 14 days after ovariectomy surgery...
July 2017: Journal of Natural Medicines
Mohamed S Abdelfattah, Mohammed I Y Elmallah, Adal A Mohamed, Masami Ishibashi
A new ana-quinonoid tetracene metabolite, named sharkquinone (1), and the known SS-228R (2) have been isolated from the ethyl acetate extract of the culture of marine Streptomyces sp. EGY1. The strain was isolated from sediment sample collected from the Red Sea coast of Egypt. The structure of sharkquinone (1) was elucidated using detailed spectral (HRESI-MS, 1D and 2D NMR) analyses and quantum chemical calculations. This is the first report of the isolation of ana-quinonoid tetracene derivative from a natural source...
July 2017: Journal of Natural Medicines
Tharita Kitisripanya, Chadathorn Inyai, Supaluk Krittanai, Kittisak Likhitwitayawuid, Boonchoo Sritularak, Poonsakdi Ploypradith, Hiroyuki Tanaka, Satoshi Morimoto, Waraporn Putalun
Oxyresveratrol is a major active compound in the heartwood of Artocarpus lacucha. It plays an important role in anti-tyrosinase, antioxidant, anti-inflammatory, antiviral and neuroprotective properties. There are many A. lacucha commercial products available on the market for skin whitening and anti-aging effects. To evaluate the quality of raw material from the plant, a monoclonal antibody (MAb) against oxyresveratrol was generated in this study. The immunogen was prepared by the Mannich reaction for the conjugation of oxyresveratrol and cationized bovine serum albumin (cBSA)...
July 2017: Journal of Natural Medicines
Delfly B Abdjul, Hiroyuki Yamazaki, Syu-Ichi Kanno, Ayako Tomizawa, Henki Rotinsulu, Defny S Wewengkang, Deiske A Sumilat, Kazuyo Ukai, Magie M Kapojos, Michio Namikoshi
In the course of our studies on anti-mycobacterial substances from marine organisms, the known dimeric sphingolipid, leucettamol A (1), was isolated as an active component, together with the new bromopyrrole alkaloid, 5-bromophakelline (2), and twelve known congeners from the Indonesian marine sponge Agelas sp. The structure of 2 was elucidated based on its spectroscopic data. Compound 1 and its bis TFA salt showed inhibition zones of 12 and 7 mm against Mycobacterium smegmatis at 50 μg/disk, respectively, while the N,N'-diacetyl derivative (1a) was not active at 50 μg/disk...
July 2017: Journal of Natural Medicines
Xin Feng, Gejia Zhong, Daji Dengba, Jun Luo, Shouying Du
Two new polyhydroxy polyacetylenes, herpecaudenes A and B (1 and 2), were isolated from the ethanol extract of fruits of Herpetospermum caudigerum, an important Tibetan medicine. The structures of them were elucidated on the basis of extensive spectroscopic methods including UV, IR, HRESIMS, (1)H and (13)C NMR, HMBC, HSQC, and (1)H-(1)H COSY. Compound 2 showed significant inhibitory effects on NO production in LPS-activated RAW 264.7 macrophages with IC50 values of 7.05 ± 1.59 µM.
July 2017: Journal of Natural Medicines
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