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Journal of Natural Medicines

Rui Yan, Yida Cui, Bowen Deng, Jiayi Bi, Guogang Zhang
Four new flavonoid glucosides, 2″-O-(6‴-O-caffeoyl)-galactopyranosylvitexin (1), 2″-O-(6‴-O-veratroyl)-galactopyranosylvitexin (2), 2″-O-(6‴-O-feruloyl)-galactopyranosylorientin (3), 2″-O-(2‴-O-methylbutyryl)-glucopyranosylisoswertisin (4), along with three known compounds were isolated from the flowers of Trollius chinensis Bunge. Their structures were determined by extensive spectroscopic analyses.
November 17, 2018: Journal of Natural Medicines
Yingzhan Tang, Guangyue Su, Ning Li, Wenjie Li, Gang Chen, Ru Chen, Di Zhou, Yue Hou
Our previous research revealed resin of Dracaena cochinchinensis as a candidate for therapy of neurodegenerative diseases. In the present study, the material basis of Chinese Dragon's blood and the primary mechanism of the effective components are discussed. Multiple chromatography and spectra analysis were utilized to identify effective constituents. The production of NO was determined using nitrite assay in BV-2 microglial cells stimulated with lipopolysaccharide (LPS). Cell viability was tested using MTT assay...
November 13, 2018: Journal of Natural Medicines
Tomohito Kakegawa, Lucia Satiko Yoshida, Mariko Takada, Mari Noguchi, Ken Yasukawa, Hiromi Takano-Ohmuro
We have proposed that analysis of ribosome-loaded mRNAs (i.e., the translatome) is useful for elucidation of pharmacological effects of phytocompounds in immune cells, regarding the involvement of post-transcriptional regulation mechanisms. In the present study, we compared the effects of pachymic acid from Poria cocos fungus and moronic acid from propolis with those of hydrocortisone on the translatomes of THP-1 macrophages exposed to bacterial lipopolysaccharide (LPS) to find clues to their biological effects...
November 9, 2018: Journal of Natural Medicines
Jian-Wei Dong, Xue-Jiao Li, Jun-You Shi, Kai-Quan Liu
Illigera aromatica S. Z. Huang et S. L. Mo and Illigera henryi W. W. Sm., belonging to the genus Illigera (Hernandiaceae), are used as herbal medicines for promoting blood circulation and treating tuberculosis. Actinodaphnine, the major bioactive alkaloid, plays an important role in the quality controls of the herbs. In the present study, a rapid, simple, accurate, and precise proton quantitative nuclear magnetic resonance (1 H-qNMR) method was developed to determine the content of actinodaphnine in I. aromatica and I...
November 9, 2018: Journal of Natural Medicines
Naohiro Oshima, Tadatoshi Yamashita, Nahoko Uchiyama, Sumiko Hyuga, Masashi Hyuga, Jinwei Yang, Takashi Hakamatsuka, Toshihiko Hanawa, Yukihiro Goda
Ephedra Herb is a crude drug defined as the terrestrial stem of Ephedra sinica, E. intermedia, or E. equisetina. It is often used to treat headaches, bronchial asthma, nasal inflammation, and the common cold. In this study, we isolated characteristic non-alkaloidal constituents from the extracts and identified them in relation to the habitat of Ephedra Herb. Extracts were prepared from Ephedra Herb collected from Inner Mongolia and Gansu. High-performance liquid chromatography was performed to quantitatively analyse the amount of ephedrine alkaloids in each extract...
November 7, 2018: Journal of Natural Medicines
Ryuichiro Suzuki, Satoshi Fukami, Mineko Tomomura, Akito Tomomura, Yoshiaki Shirataki
Bone-forming osteoblasts are differentiated from mesenchymal stem cells and dysregulation of this differentiation can lead to osteoporosis. Meanwhile, bone-resorbing osteoclasts are both differentiated and multinucleated from hematopoietic precursor cells of monocyte and/or macrophage lineage. Bone resorption inhibitors such as bisphosphonates and estrogen are used to treat osteoporosis. However, the adverse effects of the long-term use of these medicines are of concern, and so the development of new therapies to ameliorate osteoporosis is desirable...
November 3, 2018: Journal of Natural Medicines
Yuan Liu, Yanmeng Bi, Chan Mo, Ting Zeng, Sha Huang, Lei Gao, Xuegang Sun, Zhiping Lv
The present study was designed to investigate the effects of betulinic acid on human hepatic stellate cells in vitro and C57BL/6 mice in vivo, as well as the signaling pathways involved. In this study, we explored the effects of betulinic acid on expression of alpha smooth muscle actin and autophagy-related proteins. Betulinic acid reduced pathological damage associated with liver fibrosis, as well as serum platelet-derived growth factor and serum hydroxyproline levels. Furthermore, betulinic acid downregulated the expression of alpha smooth muscle actin and type I collagen in mouse liver and upregulated the expression of microtubule-associated protein light chain 3B and autophagy-related gene 7 at the gene and protein levels...
October 30, 2018: Journal of Natural Medicines
Wei Wang, Ken-Ichi Nakashima, Takao Hirai, Makoto Inoue
Neuronal cell death induced by amyloid-β (Aβ) oligomers is implicated in neuronal degeneration and is a leading cause of Alzheimer's disease (AD). Therefore, to identify effective therapeutic agents for AD, we investigated the neuroprotective effects of two naturally occurring retinoid X receptor (RXR) agonists (SPF1 and SPF2), isolated from the root of Sophora tonkinensis Gagnep., on the Aβ25-35 -induced cytotoxicity against nerve growth factor-differentiated rat pheochromocytoma (PC12) cells. Pretreatment with SPFs significantly prevented Aβ25-35 -induced apoptosis in PC12 cells, similarly to the synthetic RXR agonist bexarotene...
October 30, 2018: Journal of Natural Medicines
Hiroaki Nakanishi, Katsumi Yoneyama, Yoshie Hayashizaki, Masaaki Hara, Aya Takada, Kazuyuki Saito
We established widely applicable DNA extraction methods to identify the origins of crude drugs derived from animals. Twenty-one samples including 17 kinds of crude drug derived from animals were examined. DNA was extracted from most of the crude drugs by adjustment of the QIAamp® DNA Mini Kit. DNA extraction was performed successfully using phenol to remove impurities after applying a proteinase treatment. DNA extraction was performed successfully by decalcification treatment using ethylenediaminetetraacetic acid (EDTA), before applying the proteinase treatment for crude drugs having high calcium content, such as those from oyster shell and cuttlefish bone...
October 29, 2018: Journal of Natural Medicines
Naoko Sato, Wei Li, Hiroaki Takemoto, Mio Takeuchi, Ai Nakamura, Emi Tokura, Chie Akahane, Kanako Ueno, Kana Komatsu, Noriko Kuriyama, Toshihisa Onoda, Koji Higai, Kazuo Koike
Oxidative stress due to the overproduction of reactive oxygen species plays an important role in the pathogenesis of various diseases. In the present study, we comprehensively evaluated the antioxidant activities of 147 oral formulations of Japanese traditional herbal medicines (Kampo medicines), representing the entire panel of oral Kampo medicines listed in the Japanese National Health Insurance Drug List, using in vitro radical scavenging assays, including the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity assay, the superoxide anion scavenging activity assay, and the oxygen radical absorption capacity assay...
October 29, 2018: Journal of Natural Medicines
Yi Zhang, Peijian Huang, Wei He, Kaunda Joseph Sakah, Jingya Ruan, Zheng Li, Tao Wang
Three new compounds, citrusauranosides A (1), B (2), and C (3), along with 22 known compounds (4-25) were obtained from the 70% ethanol-water extract of the fruits of Citrus aurantium L.. Their structures were identified by spectroscopic methods. Among the known compounds, 14, 15, 17 and 23 were firstly obtained from Citrus genus, and the NMR data of 17 is reported here for the first time. Moreover, inhibitory effects of all compounds on motility of mouse isolated intestine tissue were determined. As a result, 1, 4-8, and 11 displayed significant inhibitory effects on contraction tension...
October 26, 2018: Journal of Natural Medicines
Yumi Nishiyama, Yuki Noda, Noriyoshi Nakatani, Nobukazu Shitan, Tamotsu Sudo, Atsushi Kato, Patrick B Chalo Mutiso
Three aromatic compounds, 2α,3α-epoxyflavan-5,7,4'-triol-(4β → 8)-afzelechin (1), 2β,3β-epoxyflavan-5,7,4'-triol-(4α → 8)-epiafzelechin (2), and methyl 4-ethoxy-2-hydroxy-6-propylbenzoate (3), as well as eight known compounds (4-11) were isolated from the bark of Cassipourea malosana (Rhizophoraceae). Their structures were determined on the basis of an analysis of spectroscopic data. The in vitro cytotoxic activities of these compounds against human ovarian cancer cell line TOV21G were evaluated...
October 23, 2018: Journal of Natural Medicines
Miho Hirai, Michiho Ito
The sedative effects of the essential oil released by living Ocimum basilicum (basil) plants were investigated using a mouse activity monitoring system. Ocimum basilicum plants were grown in a hydroponic chamber, and either the headspace air from the hydroponic chamber or the essential oil extracted from mature plants was administered by the inhalation route to mice in an open field test. The most effective dose of O. basilicum essential oil for reducing the locomotor activity of the mice was found to be 4...
October 20, 2018: Journal of Natural Medicines
Tomoki Iguchi, Minpei Kuroda, Rei Naito, Tomoyuki Watanabe, Yukiko Matsuo, Akihito Yokosuka, Yoshihiro Mimaki
A search for cytotoxic cholestane glycosides from Ornithogalum saundersiae bulbs resulted in the isolation of three new OSW-1 analogues (1-3), a new cholestane bisdesmoside (4), a 5β-cholestane diglycoside (5), and four new 24(23 → 22)-abeo-cholestane glycosides (6-9), together with 11 known cholestane glycosides (10-20), including OSW-1 (11). The structures of 1-9 were determined based on conventional spectroscopic analysis and chemical evidence. As expected, based on previous data, 1-3 exhibited potent cytotoxic activity against HL-60 human promyelocytic leukemia cells and A549 human lung adenocarcinoma cells...
October 16, 2018: Journal of Natural Medicines
Pan Liu, Huixiang Li, Ruiling Luan, Guiyan Huang, Yanan Liu, Mengdi Wang, Qiuli Chao, Liying Wang, Danna Li, Huaying Fan, Daquan Chen, Linyu Li, Keiichi Matsuzaki, Wei Li, Kazuo Koike, Feng Zhao
A compound library, which consists of 75 natural β-carboline-type or canthinone-type alkaloids from Simaroubaceae plants and their chemical synthetic analogues, was screened for the anti-inflammatory activity by inhibition of the overproduction of inflammatory mediator nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells. Six compounds, namely, benzalharman (23), kumujian (27), 1-ethyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (37), 1-acetophenone-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (42), cathin-6-one (46), and 9-methoxy-cathin-6-one (57), exhibited significant inhibitory activity on the overproduction of NO with good dose dependency...
October 15, 2018: Journal of Natural Medicines
Satoru Tatsuno, Akihito Yokosuka, Fusako Hatsuma, Yuto Mashiko, Yoshihiro Mimaki
Seven new pregnane glycosides (1-7) and eight known compounds (8-15) were isolated from the bark of Marsdenia cundurango (Asclepiadaceae). The structures of 1-7 were determined by spectroscopic analysis, including two-dimension NMR spectroscopy, chemical transformations, and chromatographic analysis of the hydrolyzed products. The isolated compounds 1-15 were evaluated for their cytotoxic activity against HL-60 human leukemia cells, A549 human lung adenocarcinoma cells, and TIG-3 normal human lung cells, including apoptosis-inducing activity of a representative pregnane glycoside in HL-60 cells...
September 24, 2018: Journal of Natural Medicines
Peng Li, Junchao Kong, Zhuming Chen, Shuai Huang, Guihe Lv, Bo Wei, Jinsong Wei, Kaipeng Jing, Juanhua Quan, Jiaqi Chu
Osteoporosis is characterized by low bone mass and the degeneration of bone structure, conditions which increase the risk of fracture. Aloin has been shown to affect bone metabolism, but its role in osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) remains unclear. The aim of our study was to determine whether aloin promotes the proliferation and osteogenic differentiation of BMSCs and, if so, whether it acts via activation of the ERK1/2-Runx2 signaling pathway. We found that the different concentrations of aloin tested had no obvious cytotoxic effects on the viability of BMSCs...
September 14, 2018: Journal of Natural Medicines
Mayumi Hayata, Norihisa Watanabe, Noriaki Kamio, Muneaki Tamura, Keiko Nodomi, Kiyotaka Tanaka, Arunasiri Iddamalgoda, Hiromasa Tsuda, Yorimasa Ogata, Shuichi Sato, Kouichiro Ueda, Kenichi Imai
Periodontal diseases are a major public health problem affecting over half of the adult population worldwide. Lipopolysaccharide (LPS) produced by the periodontopathic bacterium Porphyromonas gingivalis induces the expression of inflammatory cytokines that promote inflammatory bone destruction. Mounting evidence supports that periodontal diseases are involved in the onset and progression of several systemic diseases, such as aspiration pneumonia and diabetes. Although treatment of periodontal diseases by removing the periodontopathic bacteria by brushing is a standard practice, it has limitations and is not effective in all cases...
September 14, 2018: Journal of Natural Medicines
Changde Wang, Chunlan Wu, Zhenguo Yan, Xiao Cheng
A stroke is a severe life-threatening disease with high fatality and disability rate. This investigation aimed to study the effect of Xiaoyao-jieyu-san (XYJY) on post-stroke depression (PSD) and its potential mechanisms. PSD rats were prepared using middle cerebral artery embolization (MCAO) and chronic unpredictable mild stress (CUMS), and divided into six groups (n = 10)-sham; MCAO; MCAO + CUMS (PSD); PSD + fluoxetine (1.84 mg/kg/day, 4 weeks); and PSD + XYJY (450 mg/kg/day and 900 mg/kg/day, 4 weeks)...
September 7, 2018: Journal of Natural Medicines
Jiao Mo, Renhua Yang, Fan Li, Bo He, Xiaochao Zhang, Yuqin Zhao, Zhiqiang Shen, Peng Chen
Abnormal osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) has been correlated with the pathogenesis of osteoporosis. Geraniin, a polyphenolic compound isolated from Phyllanthus amarus, is effective in preventing osteoporosis, but the mechanisms of action of geraniin and the impact of osteoporotic condition on drug action are not known. In this study we compared the proliferation and osteoblastic differentiation potential of BMSCs from normal rats with that from osteoporotic rats, and examined the responses of both BMSCs to geraniin in parallel...
September 7, 2018: Journal of Natural Medicines
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