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Journal of Natural Medicines

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https://www.readbyqxmd.com/read/30218208/aloin-promotes-osteogenesis-of-bone-marrow-derived-mesenchymal-stem-cells-via-the-erk1-2-dependent-runx2-signaling-pathway
#1
Peng Li, Junchao Kong, Zhuming Chen, Shuai Huang, Guihe Lv, Bo Wei, Jinsong Wei, Kaipeng Jing, Juanhua Quan, Jiaqi Chu
Osteoporosis is characterized by low bone mass and the degeneration of bone structure, conditions which increase the risk of fracture. Aloin has been shown to affect bone metabolism, but its role in osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) remains unclear. The aim of our study was to determine whether aloin promotes the proliferation and osteogenic differentiation of BMSCs and, if so, whether it acts via activation of the ERK1/2-Runx2 signaling pathway. We found that the different concentrations of aloin tested had no obvious cytotoxic effects on the viability of BMSCs...
September 14, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30218207/cynaropicrin-from-cynara-scolymus-l-suppresses-porphyromonas-gingivalis-lps-induced-production-of-inflammatory-cytokines-in-human-gingival-fibroblasts-and-rankl-induced-osteoclast-differentiation-in-raw264-7-cells
#2
Mayumi Hayata, Norihisa Watanabe, Noriaki Kamio, Muneaki Tamura, Keiko Nodomi, Kiyotaka Tanaka, Arunasiri Iddamalgoda, Hiromasa Tsuda, Yorimasa Ogata, Shuichi Sato, Kouichiro Ueda, Kenichi Imai
Periodontal diseases are a major public health problem affecting over half of the adult population worldwide. Lipopolysaccharide (LPS) produced by the periodontopathic bacterium Porphyromonas gingivalis induces the expression of inflammatory cytokines that promote inflammatory bone destruction. Mounting evidence supports that periodontal diseases are involved in the onset and progression of several systemic diseases, such as aspiration pneumonia and diabetes. Although treatment of periodontal diseases by removing the periodontopathic bacteria by brushing is a standard practice, it has limitations and is not effective in all cases...
September 14, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30194657/ameliorative-effect-of-xiaoyao-jieyu-san-on-post-stroke-depression-and-its-potential-mechanisms
#3
Changde Wang, Chunlan Wu, Zhenguo Yan, Xiao Cheng
A stroke is a severe life-threatening disease with high fatality and disability rate. This investigation aimed to study the effect of Xiaoyao-jieyu-san (XYJY) on post-stroke depression (PSD) and its potential mechanisms. PSD rats were prepared using middle cerebral artery embolization (MCAO) and chronic unpredictable mild stress (CUMS), and divided into six groups (n = 10)-sham; MCAO; MCAO + CUMS (PSD); PSD + fluoxetine (1.84 mg/kg/day, 4 weeks); and PSD + XYJY (450 mg/kg/day and 900 mg/kg/day, 4 weeks)...
September 7, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30194656/geraniin-promotes-osteogenic-differentiation-of-bone-marrow-mesenchymal-stem-cells-bmscs-via-activating-%C3%AE-catenin-a-comparative-study-between-bmscs-from-normal-and-osteoporotic-rats
#4
Jiao Mo, Renhua Yang, Fan Li, Bo He, Xiaochao Zhang, Yuqin Zhao, Zhiqiang Shen, Peng Chen
Abnormal osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) has been correlated with the pathogenesis of osteoporosis. Geraniin, a polyphenolic compound isolated from Phyllanthus amarus, is effective in preventing osteoporosis, but the mechanisms of action of geraniin and the impact of osteoporotic condition on drug action are not known. In this study we compared the proliferation and osteoblastic differentiation potential of BMSCs from normal rats with that from osteoporotic rats, and examined the responses of both BMSCs to geraniin in parallel...
September 7, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30191382/polydatin-protects-against-acute-myocardial-infarction-induced-cardiac-damage-by-activation-of-nrf2-ho-1-signaling
#5
Guo Chen, Guorong Liu, Dawei Cao, Mingming Jin, Dongfeng Guo, Xiaoyan Yuan
Polydatin is a traditional Chinese medicine that provides myocardial protection after acute myocardial infarction (AMI). The study aim was to investigate the myocardial protection polydatin in H9c2 myocardial cells cultured in a hypoxic atmosphere and in a rat AMI model induced by ligating the left anterior descending coronary artery and treated with polydatin 100 mg/kg/day for 30 days. The involvement of Nrf2 in mediating the effects of polydatin was investigated in H9c2 cells following Nrf2 knockdown by transfection of siRNA...
September 6, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30182180/new-depsidone-and-dichromone-from-the-stems-of-garcinia-paucinervis-with-antiproliferative-activity
#6
CuiCui Jia, JingJing Xue, XinYu Li, DaHong Li, ZhanLin Li, HuiMing Hua
A new depsidone, paucinervin Q (1), a new dichromone, paucinervin R (2), and a known compound, paucinervin B (3), were isolated from the stems of Garcinia paucinervis by various chromatographic methods. Their structures were determined by analysis of spectroscopic data. The isolates were evaluated for their antiproliferative activity against three cancer cell lines HL-60, PC-3 and CaCo-2. Compound 1 showed significant inhibitory activities.
September 4, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30182179/a-review-of-the-ethnopharmacology-phytochemistry-and-pharmacology-of-changium-smyrnioides-wolff
#7
REVIEW
Lu-Jing Lei, Wen-Le Wang, Jie Wang, Li-Juan Lv, Min-Hui Li
Changium smyrnioides Wolff is a monotypic species of the genus Changium Wolff which is only found in eastern China. C. smyrnioides has been used as a traditional medicine for ages to treat cough, vomiting, nausea, megrim, and carbuncle. It is also widely used to brew medicated liquor and health tea with other herbs in order to moisten the lungs and nourish blood and yin. This review comprehensively summarizes the up-to-date information on the botanical characterization, distribution, traditional uses, ethnopharmacology, phytochemistry, pharmacology, and toxicity of C...
September 4, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30173293/two-new-oleanane-derivatives-from-the-fruits-of-leonurus-japonicus-and-their-cytotoxic-activities
#8
Wenwen Peng, Guanghu Huo, Lixia Zheng, Zhonghua Xiong, Xugen Shi, Dayong Peng
Two new oleanane derivatives, leonuronins A and B (1 and 2), along with three known oleanane triterpenes (3-5) were isolated from the fruits of Leonurus japonicus. Their structures were elucidated on the basis of NMR, MS, IR and UV spectroscopic data. The new compounds were tested for cytotoxic activities against A549 and Hela cancer cell lines. Compounds 1 and 2 exhibited weak cytotoxicity with IC50 values ranging from 6.97 to 18.13 μM.
September 1, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30171417/two-new-xanthones-and-cytotoxicity-from-the-bark-of-garcinia-schomburgkiana
#9
Sutin Kaennakam, Kamonwan Mudsing, Kitiya Rassamee, Pongpun Siripong, Santi Tip-Pyang
Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3-8) and anthraquinones (9-10) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compounds 3-6 and 8 showed good cytotoxicity against all the five cancer cell lines with IC50 values in the range of 1...
August 31, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30168038/new-neolignans-from-the-seeds-of-myristica-fragrans-and-their-cytotoxic-activities
#10
Parinuch Chumkaew, Theera Srisawat
Three new dihydrobenzofuran neolignans, myticaganal A-C (1-3), along with five known compounds (4-8), were isolated from the seeds of Myristica fragrans. Their structures were elucidated by extensive spectroscopic analysis. In vitro cytotoxic activities of the isolated compounds against three human cancer cell lines (KB, oral cavity; MCF-7, breast cancer; and NCI-H187, small cell lung cancer) were evaluated. Neolignan 3 showed significant cytotoxicity against KB and NCI-H187 cell lines with IC50 values of 5...
August 30, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30132241/oenothein-b-dimeric-hydrolysable-tannin-inhibiting-hcv-invasion-from-oenothera-erythrosepala
#11
Satoru Tamura, Gang-Ming Yang, Teruaki Koitabashi, Yoshiharu Matsuura, Yasumasa Komoda, Tomikazu Kawano, Nobutoshi Murakami
The envelope proteins of the hepatitis C virus (HCV), E1 and E2, have been revealed to be essential for invasion of HCV. Thus, we were engaged in the search for the inhibitors against HCV invasion through the assay system using the model virus expressing recombinant HCV envelopes, E1 and E2. Now, we disclosed dimeric hydrolysable tannin oenothein B (1) from MeOH extract of Oenothera erythrosepala as an active principle for inhibition of HCV invasion and its potency was almost the same as that of monomeric hydrolysable tannin, tellimagrandin I (2)...
August 21, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30121934/shikonofuran-e-plays-an-anti-inflammatory-role-by-down-regulating-mapk-and-nf-%C3%AE%C2%BAb-signaling-pathways-in-lipopolysaccharide-stimulated-raw264-7-macrophages
#12
Lang Cao, Yong Xue, Zixiong Yang, Yanhong Li, Hongmei Li, Xuanqin Chen, Rongtao Li, Dan Liu
The anti-inflammatory effects of shikonofuran E from Onosma paniculatum on RAW 264.7 murine macrophage cells induced by lipopolysaccharide (LPS) were first time examined. A series of non-cytotoxic concentrations of shikonofuran E (< 10 μM) treatments were found to reduce the accumulation of pro-inflammatory cytokine, including tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), interleukin-1β (IL-1β), and inhibit the expression of nitric oxide synthase (iNOS) and cyclooxidase-2 (COX-2) in the LPS-stimulated macrophages as compared to the LPS-only treated cells...
August 18, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30116953/the-pivotal-role-of-microrna-21-in-osteoclastogenesis-inhibition-by-anthracycline-glycoside-aloin
#13
Radha Madhyastha, Harishkumar Madhyastha, Yutthana Pengjam, Queen Intan Nurrahmah, Yuichi Nakajima, Masugi Maruyama
Osteopenic disorders such as osteoporosis and rheumatoid arthritis are characterized by excessive bone resorption by osteoclasts relative to bone formation by osteoblasts. MicroRNAs are emerging as key players in bone remodeling, modulating the functions of both osteoblasts and osteoclasts. Among them, miR-21 is highly expressed in osteoclast precursors and is known to regulate genesis, differentiation, and apoptosis of osteoclasts. The pro-osteoclastogenic nature of miR-21 makes it a potential candidate as a therapeutic target to treat bone disorders...
August 16, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30105475/macrolide-sesquiterpene-pyridine-alkaloids-from-the-stems-of-tripterygium-regelii
#14
Dongsheng Fan, Ting Li, Zhiyuan Zheng, Guo-Yuan Zhu, Xiaojun Yao, Zhi-Hong Jiang, Li-Ping Bai
Nine new monomacrolide sesquiterpene pyridine alkaloids, macroregelines A-I (1-9), were isolated from the stems of Tripterygium regelii, along with a known alkaloid, tripfordine B. The structures of all the isolated compounds were characterized by extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic analyses, as well as high-resolution electrospray-ionization mass spectrometry (HRESIMS) data. Compounds 4, 5, 6, and 8 showed antiproliferative effect on human rheumatoid arthritis synovial cell line MH7A at concentration of 20 μM, reducing their viability by 7...
August 13, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30097766/seven-new-resin-glycosides-from-the-seeds-of-quamoclit-%C3%A3-multifida
#15
Masateru Ono, Maako Azuchi, Misato Ichio, Yuki Jiyoubi, Shuhei Tsutsumi, Shin Yasuda, Ryota Tsuchihasi, Masafumi Okawa, Junei Kinjo, Hitoshi Yoshimitsu, Toshihiro Nohara
Seven new resin glycosides, multifidins III (1)-IX (7), were isolated from the seeds of Quamoclit × multifida (syn. Q. sloteri House) (Convolvulaceae), along with five known glycosides, quamoclinic acid B methyl ester (8), operculin XIII (9), quamoclin I (10), QM-10 (11), and QM-12 (12). Their structures were determined on the basis of spectroscopic data and chemical evidence. These compounds were of two different types, i.e., those with macrolactone structures and those with non-macrolactone structures...
August 10, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30094599/preparation-of-menisdaurigenin-and-related-compounds
#16
Rie Shirakawa, Sanami Ishikawa, Mizuki Takahasi, Yuuka Ueno, Yoshinori Uekusa, Yuji Narukawa, Takeshi Sugai, Fumiyuki Kiuchi
Menisdaurin (1), a cyano glucoside, was first isolated in 1978 from Menispermum dauricum (Menispermaceae) and named after the plant. It has been also isolated from several plant sources. The stereochemistry of the aglycone part was first reported as (Z,4R,6S)-enantiomer of (4,6-dihydroxy-2-cyclohexen-1-ylidene)acetonitrile based on the CD spectrum of menisdaurilide (2), the α,β-unsaturated γ-lactone obtained by an acid hydrolysis of menisdaurin. Later, the absolute stereochemistry was revised as (Z,4S,6R) by X-ray crystal analysis of 1 isolated from Saniculiphyllum guangxiens...
August 9, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30084054/cycloartane-triterpenoid-23r-24e-23-acetoxymangiferonic-acid-inhibited-proliferation-and-migration-in-b16-f10-melanoma-via-mitf-downregulation-caused-by-inhibition-of-both-%C3%AE-catenin-and-c-raf-mek1-erk-signaling-axis
#17
Toshio Kaneda, Misaki Matsumoto, Yayoi Sotozono, Satoshi Fukami, Alfarius Eko Nugroho, Yusuke Hirasawa, Hadi A Hamid A, Hiroshi Morita
We recently reported that (23R, 24E)-23-acetoxymangiferonic acid (23R-AMA), a cycloartane triterpenoid isolated by activity-guided separation from a methanol extract of Garcinia sp. bark, inhibited melanin production via inhibition of tyrosinase (TYR) expression in the B16-F10 melanoma cell line. Since 23R-AMA also inhibited microphthalmia-associated transcription factor (MITF) expression, an upstream factor of TYR, these features of 23R-AMA were thought to be appropriate for development of whitening cosmetics...
August 6, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30066240/effects-of-fermented-sorghum-bicolor-l-moench-extract-on-inflammation-and-thickness-in-a-vascular-cell-and-atherosclerotic-mice-model
#18
Young Min Ham, Hae Seong Song, Jeong Eun Kwon, Hyelin Jeon, Hyun Jin Baek, Chang Won Kim, Weon-Jong Yoon, Eui Su Choung, Se Chan Kang
Atherosclerosis is a major cause of coronary heart disease. As a result of the development of atherosclerotic lesions, the walls of blood vessels become thicker and inhibit blood circulation. Atherosclerosis is caused by a high-fat diet and vascular injury. Chronic arterial inflammation plays an important role in the pathogenesis of atherosclerosis. In particular, secretion of the pro-atherogenic cytokine tumor necrosis factor-α induces expression of endothelial adhesion molecules including P-selectin, vascular cell adhesion molecule 1 (VCAM-1), and intercellular adhesion molecule 1 (ICAM-1), which mediate attachment of circulating monocytes and lymphocytes...
July 31, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30066239/selective-inhibition-of-p-gp-transporter-by-goniothalamin-derivatives-sensitizes-resistant-cancer-cells-to-chemotherapy
#19
Julia Sachs, Onat Kadioglu, Anja Weber, Vanessa Mundorf, Janina Betz, Thomas Efferth, Jörg Pietruszka, Nicole Teusch
Overexpression of efflux transporters of the ATP-binding cassette (ABC) transporter family, primarily P-glycoprotein (P-gp), is a frequent cause of multidrug resistance in cancer and leads to failure of current chemotherapies. Thus, identification of selective P-gp inhibitors might provide a basis for the development of novel anticancer drug candidates. The natural product goniothalamin and 21 derivatives were characterized regarding their ability to inhibit ABC transporter function. Among the goniothalamins, selective inhibitors of P-gp were discovered...
July 31, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/30054785/the-analgesic-effect-and-possible-mechanisms-by-which-koumine-alters-type-ii-collagen-induced-arthritis-in-rats
#20
Gui-Lin Jin, Jian Yang, Wan-Qing Chen, Jie Wang, Hong-Qiang Qiu, Ying Xu, Chang-Xi Yu
Gelsemium elegans Benth. is a toxic plant that has been used as an ancient Chinese herbal remedy for rheumatoid arthritis (RA) and nervous pain, spasticity, skin ulcers, and cancers. Koumine, one of its representative alkaloids, shows numerous promising pharmacological activities, including anti-inflammatory and analgesic activities. Here, we investigated the analgesic effect of koumine on the collagen-induced arthritis (CIA) rat model of RA and explored the potential pharmacological mechanisms underlying the analgesia...
July 27, 2018: Journal of Natural Medicines
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